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Conserved domains on  [gi|568906177|ref|XP_006495952|]
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protein Wnt-6 isoform X2 [Mus musculus]

Protein Classification

wnt family protein( domain architecture ID 14443616)

wnt family protein function in both normal development and differentiation as well as in mammary tumorigenesis

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Wnt_Wnt6 cd19338
Wnt domain found in protein Wnt-6 and similar proteins; Wnt-6 may function as a signaling ...
1-331 0e+00

Wnt domain found in protein Wnt-6 and similar proteins; Wnt-6 may function as a signaling molecule which affects the development of discrete regions of tissues. It may promote tumorigenesis in gastrointestinal cancer and cervical cancer. It can compensate for the absence of ectoderm and can induce the formation of muscle cells in the limb. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


:

Pssm-ID: 381712  Cd Length: 310  Bit Score: 528.33  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177   1 MDPTSICRKARRLAGRQAELCQAEPEVVAELARGARLGVRECQFQFRFRRWNCSSHSKAFGRVLQQDIRETAFVFAITAA 80
Cdd:cd19338    1 MDPNSICRKTRRLKGKQREICRKEPEILEEVAKGAKLGIRECQYQFRNRRWNCSTSRKSFGKILKRDTRETAFVYAITSA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177  81 GASHAVTQACSMGELLQCGC-QAPRGRAPPrpsgllgtpgppgptgspdasAAWEWGGCGDDVDFGDEKSRLFMDAQHKR 159
Cdd:cd19338   81 GVTYSVTRACSMGELLQCGCdKSKRGKSTE---------------------GEWEWGGCSDNVRYGYRKSREFMDAKEKN 139
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177 160 gRGDIRALVQLHNNEAGRLAVRSHTRTECKCHGLSGSCALRTCWQKLPPFREVGARLLERFHGASRVMGTNDGKALLPAV 239
Cdd:cd19338  140 -RSDIRTLMNLHNNEAGRLAVKNNMRKECKCHGLSGSCTLKTCWRKMPPFREVGDRLKERFDGAIKVKGSNDGKSLIPEG 218
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177 240 RTLKPPGRADLLYAADSPDFCAPNRRTGSPGTRGRACNSSAPDLSGCDLLCCGRGHRQESVQLEENCLCRFHWCCVVQCH 319
Cdd:cd19338  219 KTIKPPTKEDLVYLEESPDFCEPNKKTGSLGTRGRECNRTSMGVDGCDLLCCGRGYQTEVRVVEENCNCRFHWCCEVKCE 298
                        330
                 ....*....|..
gi 568906177 320 RCRVRKELSLCL 331
Cdd:cd19338  299 TCKVRKEIHTCN 310
 
Name Accession Description Interval E-value
Wnt_Wnt6 cd19338
Wnt domain found in protein Wnt-6 and similar proteins; Wnt-6 may function as a signaling ...
1-331 0e+00

Wnt domain found in protein Wnt-6 and similar proteins; Wnt-6 may function as a signaling molecule which affects the development of discrete regions of tissues. It may promote tumorigenesis in gastrointestinal cancer and cervical cancer. It can compensate for the absence of ectoderm and can induce the formation of muscle cells in the limb. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381712  Cd Length: 310  Bit Score: 528.33  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177   1 MDPTSICRKARRLAGRQAELCQAEPEVVAELARGARLGVRECQFQFRFRRWNCSSHSKAFGRVLQQDIRETAFVFAITAA 80
Cdd:cd19338    1 MDPNSICRKTRRLKGKQREICRKEPEILEEVAKGAKLGIRECQYQFRNRRWNCSTSRKSFGKILKRDTRETAFVYAITSA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177  81 GASHAVTQACSMGELLQCGC-QAPRGRAPPrpsgllgtpgppgptgspdasAAWEWGGCGDDVDFGDEKSRLFMDAQHKR 159
Cdd:cd19338   81 GVTYSVTRACSMGELLQCGCdKSKRGKSTE---------------------GEWEWGGCSDNVRYGYRKSREFMDAKEKN 139
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177 160 gRGDIRALVQLHNNEAGRLAVRSHTRTECKCHGLSGSCALRTCWQKLPPFREVGARLLERFHGASRVMGTNDGKALLPAV 239
Cdd:cd19338  140 -RSDIRTLMNLHNNEAGRLAVKNNMRKECKCHGLSGSCTLKTCWRKMPPFREVGDRLKERFDGAIKVKGSNDGKSLIPEG 218
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177 240 RTLKPPGRADLLYAADSPDFCAPNRRTGSPGTRGRACNSSAPDLSGCDLLCCGRGHRQESVQLEENCLCRFHWCCVVQCH 319
Cdd:cd19338  219 KTIKPPTKEDLVYLEESPDFCEPNKKTGSLGTRGRECNRTSMGVDGCDLLCCGRGYQTEVRVVEENCNCRFHWCCEVKCE 298
                        330
                 ....*....|..
gi 568906177 320 RCRVRKELSLCL 331
Cdd:cd19338  299 TCKVRKEIHTCN 310
wnt pfam00110
wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, ...
9-331 3.92e-159

wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, unicellular eukaryotes or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families.


Pssm-ID: 459677  Cd Length: 307  Bit Score: 447.00  E-value: 3.92e-159
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177    9 KARRLAGRQAELCQAEPEVVAELARGARLGVRECQFQFRFRRWNCSSHSKA---FGRVLQQDIRETAFVFAITAAGASHA 85
Cdd:pfam00110   1 KLPGLSPRQRRLCRRNPDVMASVAEGAQLAIEECQHQFRNRRWNCSTLENKrpvFGKVLKRGTRETAFVYAISSAGVTHA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177   86 VTQACSMGELLQCGCQAPRGRAPPRPsgllgtpgppgptgspdasAAWEWGGCGDDVDFGDEKSRLFMDAQHKRGRgDIR 165
Cdd:pfam00110  81 VTRACSSGELTSCGCDRKKRGKSSGE-------------------GGWEWGGCSDNIDYGYKFSRKFVDAREKKRR-DAR 140
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177  166 ALVQLHNNEAGRLAVRSHTRTECKCHGLSGSCALRTCWQKLPPFREVGARLLERFHGASRV-MGTNDGKALLPAVRTLKP 244
Cdd:pfam00110 141 ALMNLHNNEAGRKAVKSNMRTECKCHGVSGSCSVKTCWKALPPFREVGDRLKEKYDGAVKVnRRRNKRGRLVPRNSRFKP 220
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177  245 PGRADLLYAADSPDFCAPNRRTGSPGTRGRACNSSAPDLSGCDLLCCGRGHRQESVQLEENCLCRFHWCCVVQCHRCRVR 324
Cdd:pfam00110 221 PTKNDLVYLEKSPDYCERNPKTGSLGTRGRECNKTSSGPDGCDLLCCGRGYNTRTVTVTERCNCKFHWCCYVKCKTCTET 300

                  ....*..
gi 568906177  325 KELSLCL 331
Cdd:pfam00110 301 VEVYTCK 307
WNT1 smart00097
found in Wnt-1;
9-331 7.18e-150

found in Wnt-1;


Pssm-ID: 128408  Cd Length: 305  Bit Score: 423.27  E-value: 7.18e-150
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177     9 KARRLAGRQAELCQAEPEVVAELARGARLGVRECQFQFRFRRWNCSSHS--KAFGRVLQQDIRETAFVFAITAAGASHAV 86
Cdd:smart00097   1 SLPGLSRRQRRLCRANPDVMISVAEGAQEGIEECQHQFRFRRWNCSTLDnaSVFGKVLRQGTRETAFVYAISSAGVAHAV 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177    87 TQACSMGELLQCGCQA-PRGRAPPRpsgllgtpgppgptgspdasaAWEWGGCGDDVDFGDEKSRLFMDAQHKRGrgDIR 165
Cdd:smart00097  81 TRACSEGELDSCGCDYrKRGRAGGR---------------------GWKWGGCSDNIDFGIRFSREFVDARERGK--DAR 137
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177   166 ALVQLHNNEAGRLAVRSHTRTECKCHGLSGSCALRTCWQKLPPFREVGARLLERFHGASRVMGTNDG--KALLPAVRTLK 243
Cdd:smart00097 138 ALMNLHNNEAGRLAVKKTMKRECKCHGVSGSCTVKTCWLQLPDFRKVGDYLKEKYDGASEVEVDKRGtnKAPVPKNSTFK 217
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177   244 PPGRADLLYAADSPDFCAPNRRTGSPGTRGRACNSSAPDLSGCDLLCCGRGHRQESVQLEENCLCRFHWCCVVQCHRCRV 323
Cdd:smart00097 218 PPTETDLVYLESSPDFCEKNPKTGSLGTQGRQCNKTSKGLDGCDLLCCGRGYNTRTVEVVERCNCKFHWCCYVKCKQCRE 297

                   ....*...
gi 568906177   324 RKELSLCL 331
Cdd:smart00097 298 TVEKHTCK 305
 
Name Accession Description Interval E-value
Wnt_Wnt6 cd19338
Wnt domain found in protein Wnt-6 and similar proteins; Wnt-6 may function as a signaling ...
1-331 0e+00

Wnt domain found in protein Wnt-6 and similar proteins; Wnt-6 may function as a signaling molecule which affects the development of discrete regions of tissues. It may promote tumorigenesis in gastrointestinal cancer and cervical cancer. It can compensate for the absence of ectoderm and can induce the formation of muscle cells in the limb. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381712  Cd Length: 310  Bit Score: 528.33  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177   1 MDPTSICRKARRLAGRQAELCQAEPEVVAELARGARLGVRECQFQFRFRRWNCSSHSKAFGRVLQQDIRETAFVFAITAA 80
Cdd:cd19338    1 MDPNSICRKTRRLKGKQREICRKEPEILEEVAKGAKLGIRECQYQFRNRRWNCSTSRKSFGKILKRDTRETAFVYAITSA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177  81 GASHAVTQACSMGELLQCGC-QAPRGRAPPrpsgllgtpgppgptgspdasAAWEWGGCGDDVDFGDEKSRLFMDAQHKR 159
Cdd:cd19338   81 GVTYSVTRACSMGELLQCGCdKSKRGKSTE---------------------GEWEWGGCSDNVRYGYRKSREFMDAKEKN 139
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177 160 gRGDIRALVQLHNNEAGRLAVRSHTRTECKCHGLSGSCALRTCWQKLPPFREVGARLLERFHGASRVMGTNDGKALLPAV 239
Cdd:cd19338  140 -RSDIRTLMNLHNNEAGRLAVKNNMRKECKCHGLSGSCTLKTCWRKMPPFREVGDRLKERFDGAIKVKGSNDGKSLIPEG 218
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177 240 RTLKPPGRADLLYAADSPDFCAPNRRTGSPGTRGRACNSSAPDLSGCDLLCCGRGHRQESVQLEENCLCRFHWCCVVQCH 319
Cdd:cd19338  219 KTIKPPTKEDLVYLEESPDFCEPNKKTGSLGTRGRECNRTSMGVDGCDLLCCGRGYQTEVRVVEENCNCRFHWCCEVKCE 298
                        330
                 ....*....|..
gi 568906177 320 RCRVRKELSLCL 331
Cdd:cd19338  299 TCKVRKEIHTCN 310
wnt pfam00110
wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, ...
9-331 3.92e-159

wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, unicellular eukaryotes or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families.


Pssm-ID: 459677  Cd Length: 307  Bit Score: 447.00  E-value: 3.92e-159
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177    9 KARRLAGRQAELCQAEPEVVAELARGARLGVRECQFQFRFRRWNCSSHSKA---FGRVLQQDIRETAFVFAITAAGASHA 85
Cdd:pfam00110   1 KLPGLSPRQRRLCRRNPDVMASVAEGAQLAIEECQHQFRNRRWNCSTLENKrpvFGKVLKRGTRETAFVYAISSAGVTHA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177   86 VTQACSMGELLQCGCQAPRGRAPPRPsgllgtpgppgptgspdasAAWEWGGCGDDVDFGDEKSRLFMDAQHKRGRgDIR 165
Cdd:pfam00110  81 VTRACSSGELTSCGCDRKKRGKSSGE-------------------GGWEWGGCSDNIDYGYKFSRKFVDAREKKRR-DAR 140
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177  166 ALVQLHNNEAGRLAVRSHTRTECKCHGLSGSCALRTCWQKLPPFREVGARLLERFHGASRV-MGTNDGKALLPAVRTLKP 244
Cdd:pfam00110 141 ALMNLHNNEAGRKAVKSNMRTECKCHGVSGSCSVKTCWKALPPFREVGDRLKEKYDGAVKVnRRRNKRGRLVPRNSRFKP 220
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177  245 PGRADLLYAADSPDFCAPNRRTGSPGTRGRACNSSAPDLSGCDLLCCGRGHRQESVQLEENCLCRFHWCCVVQCHRCRVR 324
Cdd:pfam00110 221 PTKNDLVYLEKSPDYCERNPKTGSLGTRGRECNKTSSGPDGCDLLCCGRGYNTRTVTVTERCNCKFHWCCYVKCKTCTET 300

                  ....*..
gi 568906177  325 KELSLCL 331
Cdd:pfam00110 301 VEVYTCK 307
WNT1 smart00097
found in Wnt-1;
9-331 7.18e-150

found in Wnt-1;


Pssm-ID: 128408  Cd Length: 305  Bit Score: 423.27  E-value: 7.18e-150
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177     9 KARRLAGRQAELCQAEPEVVAELARGARLGVRECQFQFRFRRWNCSSHS--KAFGRVLQQDIRETAFVFAITAAGASHAV 86
Cdd:smart00097   1 SLPGLSRRQRRLCRANPDVMISVAEGAQEGIEECQHQFRFRRWNCSTLDnaSVFGKVLRQGTRETAFVYAISSAGVAHAV 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177    87 TQACSMGELLQCGCQA-PRGRAPPRpsgllgtpgppgptgspdasaAWEWGGCGDDVDFGDEKSRLFMDAQHKRGrgDIR 165
Cdd:smart00097  81 TRACSEGELDSCGCDYrKRGRAGGR---------------------GWKWGGCSDNIDFGIRFSREFVDARERGK--DAR 137
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177   166 ALVQLHNNEAGRLAVRSHTRTECKCHGLSGSCALRTCWQKLPPFREVGARLLERFHGASRVMGTNDG--KALLPAVRTLK 243
Cdd:smart00097 138 ALMNLHNNEAGRLAVKKTMKRECKCHGVSGSCTVKTCWLQLPDFRKVGDYLKEKYDGASEVEVDKRGtnKAPVPKNSTFK 217
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177   244 PPGRADLLYAADSPDFCAPNRRTGSPGTRGRACNSSAPDLSGCDLLCCGRGHRQESVQLEENCLCRFHWCCVVQCHRCRV 323
Cdd:smart00097 218 PPTETDLVYLESSPDFCEKNPKTGSLGTQGRQCNKTSKGLDGCDLLCCGRGYNTRTVEVVERCNCKFHWCCYVKCKQCRE 297

                   ....*...
gi 568906177   324 RKELSLCL 331
Cdd:smart00097 298 TVEKHTCK 305
Wnt cd13113
Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary ...
27-330 8.25e-131

Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary tumor virus (MMTV) integration site family; Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about the structure of Wnt proteins, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. Wnt signaling mediated by Wnt proteins orchestrates and influences a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381706  Cd Length: 288  Bit Score: 374.32  E-value: 8.25e-131
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177  27 VVAELARGARLGVRECQFQFRFRRWNCSSHSKA--FGRVLQQDIRETAFVFAITAAGASHAVTQACSMGELLQCGCQAPR 104
Cdd:cd13113    1 LMESIAEGAQLALKECQRQFANRRWNCSTFNEPllFGKILKRGTRETAFVHAITSAGVTHAITRACSRGKLKNCGCDRTR 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177 105 GRAPPRPSgllgtpgppgptgspdasaaWEWGGCGDDVDFGDEKSRLFMDAQHKRGRGDIRALVQLHNNEAGRLAVRSHT 184
Cdd:cd13113   81 QGPEGQGD--------------------WTWGGCSDNIKFGIKFSRKFLDAREKKKGSDARSLMNLHNNEAGRKAVKKTM 140
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177 185 RTECKCHGLSGSCALRTCWQKLPPFREVGARLLERFHGASRVMGTNDGK--ALLPAVRTLKPPGRADLLYAADSPDFCAP 262
Cdd:cd13113  141 KKKCKCHGVSGSCTTKTCWRQLPSFREIGDYLKEKYDNAVKVKLNNNGSglRLVPKRSRFRSPTETDLVYLEESPDYCEP 220
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568906177 263 NRRTGSPGTRGRACNSSAPDLSGCDLLCCGRGHRQESVQLEENCLCRFHWCCVVQCHRCRVRKELSLC 330
Cdd:cd13113  221 NPTLGSLGTAGRECNPTSPGPDSCELLCCGRGYRTETEIVTEKCNCKFVWCCEVKCETCRRTVERYTC 288
Wnt_Wnt1 cd19333
Wnt domain found in proto-oncogene Wnt-1 and similar proteins; Wnt-1, also called ...
13-331 1.67e-118

Wnt domain found in proto-oncogene Wnt-1 and similar proteins; Wnt-1, also called proto-oncogene Int-1, acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation. It plays a role in osteoblast function, bone development and bone homeostasis. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381707  Cd Length: 311  Bit Score: 343.95  E-value: 1.67e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177  13 LAGRQAELCQAEPEVVAELARGARLGVRECQFQFRFRRWNCSSHSKA-----FGRVLQQDIRETAFVFAITAAGASHAVT 87
Cdd:cd19333    1 LTKKQRRLVRQNPGTLHAIARGARMAIKECKWQFRNRRWNCPTTDSRggpnvFGKILNRGCRETAFIYAITSAAVTHSVA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177  88 QACSMGELLQCGCQAPRgRAPPRPSgllgtpgppgptgspdasaaWEWGGCGDDVDFGDEKSRLFMDAQhKRGRgDIRAL 167
Cdd:cd19333   81 RACSEGSIESCSCDYRR-RGPGGPD--------------------WEWGGCSDNIDFGRKFSREFVDAG-EKGR-DLRYL 137
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177 168 VQLHNNEAGRLAVRSHTRTECKCHGLSGSCALRTCWQKLPPFREVGARLLERFHGASRVMGTNDGKA----------LLP 237
Cdd:cd19333  138 MNLHNNEAGRVHVSSEMRQECKCHGMSGSCTVKTCWMRLPTFRTVGDRLKDRFDGASRVAYGNNGNNrgsrrakkflLEP 217
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177 238 AVRTLKPPGRADLLYAADSPDFCAPNRRTGSPGTRGRACNSSAPDLSGCDLLCCGRGHRQESVQLEENCLCRFHWCCVVQ 317
Cdd:cd19333  218 ENPNHKPPTSKDLVYFEESPNFCEKNPKLGTLGTRGRECNATSIGLDGCDLMCCGRGYRTETEEVKERCNCTFHWCCEVK 297
                        330
                 ....*....|....
gi 568906177 318 CHRCRVRKELSLCL 331
Cdd:cd19333  298 CENCTRTRTVHTCL 311
Wnt_Wnt2_like cd19334
Wnt domain found in protein Wnt-2, Wnt-2b and similar proteins; The family includes Wnt-2 and ...
6-322 6.47e-116

Wnt domain found in protein Wnt-2, Wnt-2b and similar proteins; The family includes Wnt-2 and Wnt-2b. Wnt-2, also called Int-1-like protein 1 (INT1L1), or Int-1-related protein (IRP), functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. It plays an important role in embryonic lung development. Wnt-2b, also called protein Wnt-13, functions in the canonical Wnt/beta-catenin signaling pathway. It plays a redundant role in embryonic lung development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381708  Cd Length: 314  Bit Score: 337.77  E-value: 6.47e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177   6 ICRKARRLAGRQAELCQAEPEVVAELARGARLGVRECQFQFRFRRWNCS---SHSKAFGRVLQQDIRETAFVFAITAAGA 82
Cdd:cd19334    5 ICDNIPGLVSKQRQLCRKHPDVMVSIGEGAKLGVKECQYQFRNQRWNCStvdRDATVFGKVLLKGSREAAFVYAISSAGV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177  83 SHAVTQACSMGELLQCGCQAPRGRApprpsgllgtpgppgptgSPDASAAWEWGGCGDDVDFGDEKSRLFMDAQHKRGRg 162
Cdd:cd19334   85 VHAITRACSKGELLNCACDPTKRGK------------------GRDSKGEFDWGGCSDNVKYGINFARKFVDARERRVR- 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177 163 DIRALVQLHNNEAGRLAVRSHTRTECKCHGLSGSCALRTCWQKLPPFREVGARLLERFHGASRVMGTNDGKALLPAVRTL 242
Cdd:cd19334  146 DARALMNLHNNRAGRKAVKKNLKLQCKCHGVSGSCTIRTCWRALAEFREVGDYLREKYDGAVQVTMNQSGTNLLAANKGH 225
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177 243 KPPGRADLLYAADSPDFCAPNRRTGSPGTRGRACNSSAPDLSGCDLLCCGRGHRQESVQLEENCLCRFHWCCVVQCHRCR 322
Cdd:cd19334  226 KKPTRSDLVYFESSPDYCVPNPETGSLGTAGRVCNKTSTGTDGCDIMCCGRGYDTTRVRRTTKCNCKFHWCCQVKCKTCT 305
Wnt_Wnt10 cd19342
Wnt domain found in protein Wnt-10a, Wnt-10b and similar proteins; The family includes protein ...
5-330 4.26e-114

Wnt domain found in protein Wnt-10a, Wnt-10b and similar proteins; The family includes protein Wnt-10a and Wnt-10b. Wnt-10a plays a role in normal ectoderm development. It is required for normal postnatal development and maintenance of tongue papillae and sweat ducts, as well as normal hair follicle function. Wnt-10b, also called protein Wnt-12, specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. It is involved in signaling networks controlling stemness, pluripotency, and cell fate decisions. Wnt-10b is unique and plays an important role in differentiation of epithelial cells in the hair follicle. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381716  Cd Length: 316  Bit Score: 333.08  E-value: 4.26e-114
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177   5 SICRKARRLAGRQAELCQAEPEVVAELARGARLGVRECQFQFRFRRWNCSS--------HSKAFgrvLQQDIRETAFVFA 76
Cdd:cd19342    2 TVCRTFPGLTREQLELCRRYPDVTASAIQGIQLAVHECQRQFRDHRWNCSSletknknpHTSPI---LSRGYRETAFAYA 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177  77 ITAAGASHAVTQACSMGELLQCGCQAPRGRAPPRpsgllgtpgppgptgspdaSAAWEWGGCGDDVDFGDEKSRLFMDAQ 156
Cdd:cd19342   79 ISAAGVAHQVARACSLGKLLSCGCDRSRRGKRSS-------------------GNDWKWGGCSHNLDFGEKFSRKFLDSR 139
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177 157 HKRGrgDIRALVQLHNNEAGRLAVRSHTRTECKCHGLSGSCALRTCWQKLPPFREVGARLLERFHGASRVMGTNDGK--- 233
Cdd:cd19342  140 EKAR--DIHSRMNLHNNRAGRLAVSENMERKCKCHGMSGSCELKTCWKAAPDFREVGDILKEKYDHATLVDQSNLNNgar 217
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177 234 -ALLPAVRTLKPPGRADLLYAADSPDFCAPNRRTGSPGTRGRACNSSAPDLSGCDLLCCGRGHRQESVQLEENCLCRFHW 312
Cdd:cd19342  218 rRRLTRRKRRRRPPKTDLVYYERSPNFCEADPSLDSPGTRGRVCNKTSTGPDSCDSLCCGRGYNTVRQTRTERCNCRFHW 297
                        330
                 ....*....|....*...
gi 568906177 313 CCVVQCHRCRVRKELSLC 330
Cdd:cd19342  298 CCYVVCEKCTETEWVTVC 315
Wnt_Wnt4 cd19336
Wnt domain found in protein Wnt-4 and similar proteins; Wnt-4 may function as a signaling ...
7-331 1.49e-111

Wnt domain found in protein Wnt-4 and similar proteins; Wnt-4 may function as a signaling molecule which affects the development of discrete regions of tissues. Its overexpression may be associated with abnormal proliferation in human breast tissue. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381710  Cd Length: 310  Bit Score: 326.19  E-value: 1.49e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177   7 CRKARRLAGRQAELCQAEPEVVAELARGARLGVRECQFQFRFRRWNCSS--HSKAFGRVLQQDIRETAFVFAITAAGASH 84
Cdd:cd19336    1 CESLKGLTKRQVQFCKRNLEVMDSVRRGAQLAIEECQFQFRNRRWNCSTldKEPVFGKVLNQGTREAAFVHAISSAGVAH 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177  85 AVTQACSMGELLQCGCQAP-RGRAPprpsgllgtpgppgptgspdasAAWEWGGCGDDVDFGDEKSRLFMDAQHKRGR-- 161
Cdd:cd19336   81 AVTRACSSGELEKCGCDRSvRGRSP----------------------EGFQWSGCSDNVAYGVAFSKSFVDARERRKGra 138
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177 162 GDIRALVQLHNNEAGRLAVRSHTRTECKCHGLSGSCALRTCWQKLPPFREVGARLLERFHGASRV-MGTNDGK-ALLPAV 239
Cdd:cd19336  139 SSSRALMNLHNNEAGRKAIEKNMRVECKCHGVSGSCELKTCWRAMPTFREVGNILKEKFDGATEVqQKRIGSRpVLVPKN 218
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177 240 RTLKPPGRADLLYAADSPDFCAPNRRTGSPGTRGRACNSSAPDLSGCDLLCCGRGHRQESVQLEENCLCRFHWCCVVQCH 319
Cdd:cd19336  219 PQFKPHTDADLVYLDSSPDFCEPDPKTGSLGTHGRVCNKTSKAIDGCDLLCCGRGYVTRTEEVVERCSCKFHWCCYVKCK 298
                        330
                 ....*....|..
gi 568906177 320 RCRVRKELSLCL 331
Cdd:cd19336  299 TCRREVEVHTCR 310
Wnt_Wnt7 cd19339
Wnt domain found in protein Wnt-7a, Wnt-7b and similar proteins; The family includes Wnt-7a ...
6-330 1.39e-109

Wnt domain found in protein Wnt-7a, Wnt-7b and similar proteins; The family includes Wnt-7a and Wnt-7b. Wnt-7a acts as a canonical Wnt ligand that modulates the synaptic vesicle cycle and synaptic transmission in hippocampal neurons. It also plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development, and urogenital tract development. Wnt-7b functions in the canonical Wnt/beta-catenin signaling pathway in vascular smooth muscle cells. It is required for normal fusion of the chorion and the allantois during placenta development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381713  Cd Length: 313  Bit Score: 321.55  E-value: 1.39e-109
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177   6 ICRKARRLAGRQAELCQAEPEVVAELARGARLGVRECQFQFRFRRWNCSS--HSKAFGRVLQQDIRETAFVFAITAAGAS 83
Cdd:cd19339    1 ICNKIPGLTPRQRAICQSRPDAIVAIGEGAQLGIEECQFQFRNHRWNCTLlgERTVFGQELPVGSREAAFTYAITSAGVA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177  84 HAVTQACSMGELLQCGCqaPRGRAPPRPSgllgtpgppgptgspdaSAAWEWGGCGDDVDFGDEKSRLFMDAQHKRGrgD 163
Cdd:cd19339   81 YAITQACSQGNLSDCGC--DKSKKGYGKS-----------------DEGWKWGGCSADVKYGLRFSRKFVDAREVKR--N 139
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177 164 IRALVQLHNNEAGRLAVRSHTRTECKCHGLSGSCALRTCWQKLPPFREVGARLLERFHGASRV------MGTNDGKALLP 237
Cdd:cd19339  140 ARSLMNLHNNEAGRKAVEENLKLECKCHGVSGSCTTKTCWTTLPSFREIGDYLKKKYERARRVepvrgrRRRRPTFLKLK 219
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177 238 AVRTLKPPGRADLLYAADSPDFCAPNRRTGSPGTRGRACNSSAPDLSGCDLLCCGRGHRQESVQLEENCLCRFHWCCVVQ 317
Cdd:cd19339  220 ISRKYKKPRPRDLVYLEKSPNYCEKDPLTGSLGTVGRRCNRTSTGTDGCDLMCCGRGYNTHQYTKTWQCNCKFHWCCYVK 299
                        330
                 ....*....|...
gi 568906177 318 CHRCRVRKELSLC 330
Cdd:cd19339  300 CNTCSERTEEYTC 312
Wnt_Wnt11 cd19343
Wnt domain found in protein Wnt-11 and similar proteins; Wnt-11 may be a signaling molecule ...
13-331 2.16e-109

Wnt domain found in protein Wnt-11 and similar proteins; Wnt-11 may be a signaling molecule which has possible roles in the development of skeleton, kidney and lung. It is a positive regulator of the Wnt signaling pathway, which plays a crucial role in carcinogenesis. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381717  Cd Length: 305  Bit Score: 320.74  E-value: 2.16e-109
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177  13 LAGRQAELCQAEPEVVAELARGARLGVRECQFQFRFRRWNCSSHSKA--FGRVLQQDIRETAFVFAITAAGASHAVTQAC 90
Cdd:cd19343    1 LVGDQVKLCRRNLELMPSVVEAARLTVDTCQEQFADRRWNCSSIELApnFTPDLTRGTREQAFVYALSSAALTHTIARAC 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177  91 SMGELLQCGCqaprGRAPPRPsgllgtpgppgptgspdASAAWEWGGCGDDVDFGDEKSRLFMDAQHKRGRG---DIRAL 167
Cdd:cd19343   81 ASGALPGCGC----GRLPREP-----------------PDGDFKWGGCGDNVRYGLRFAKRFTDAPEKKKKKkkrQARAL 139
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177 168 VQLHNNEAGRLAVRSHTRTECKCHGLSGSCALRTCWQKLPPFREVGARLLERFHGASRV--MGTNDGKALLPAVRTLKPP 245
Cdd:cd19343  140 MNLHNNRVGRKAVRDSLETQCKCHGVSGSCSVKTCWKALPDLSEVASRLKRKYARAVEVvsRKVGSRRKLVPKSLKVRPY 219
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177 246 GRADLLYAADSPDFCAPNRRTGSPGTRGRACNSSAPDLSGCDLLCCGRGHRQESVQLEENCLCRFHWCCVVQCHRCRVRK 325
Cdd:cd19343  220 TKDDLIYLTKSPDYCLPDEKLGSLGTRGRECNKTSVGSDSCDSMCCGRGYRTYTVEVVERCHCKYHWCCYVKCKTCRRTV 299

                 ....*.
gi 568906177 326 ELSLCL 331
Cdd:cd19343  300 EVHVCK 305
Wnt_Wnt5 cd19337
Wnt domain found in protein Wnt-5a, Wnt-5b and similar proteins; The family includes Wnt-5a ...
7-330 8.94e-108

Wnt domain found in protein Wnt-5a, Wnt-5b and similar proteins; The family includes Wnt-5a and Wnt-5b, both of which are secreted growth factors that belong to the noncanonical members of the Wingless-related MMTV-integration family. Wnt-5a can activate or inhibit canonical Wnt signaling, depending on receptor context. It specifically regulates dendritic spine formation in rodent hippocampal neurons, resulting in postsynaptic development that promotes the clustering of the postsynaptic density protein 95 (PSD-95). The overexpression of Wnt-5b is associated with cancer aggressiveness. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381711  Cd Length: 313  Bit Score: 316.88  E-value: 8.94e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177   7 CRKARRLAGRQAELCQAEPEVVAELARGARLGVRECQFQFRFRRWNCS--SHSKAFGRVLQQDIRETAFVFAITAAGASH 84
Cdd:cd19337    1 CDQLRGLSPGQRKLCQLYQDHMPSVGRGAKLAIEECQYQFRYRRWNCStpDSSSVFGPVTNIGTREAAFTYAISAAGVVH 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177  85 AVTQACSMGELLQCGC-QAPRGRAPPRpsgllgtpgppgptgspdasaAWEWGGCGDDVDFGDEKSRLFMDAQ-----HK 158
Cdd:cd19337   81 AIARACREGNLSTCGCsRERRPKDLPR---------------------DWLWGGCGDNIEYGYKFAKEFIDAReretnYP 139
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177 159 RGRGDI-RALVQLHNNEAGRLAVRSHTRTECKCHGLSGSCALRTCWQKLPPFREVGARLLERFHGASRVMGTNDGKALLP 237
Cdd:cd19337  140 RHSRELaRVLMNLHNNEAGRRAVYEKARVACKCHGVSGSCSLKTCWRQLAPFREVGDRLKDKYDGAVKVKLNRRGTLLRR 219
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177 238 AVRTLKPPGRADLLYAADSPDFCAPNRRTGSPGTRGRACNSSAPDLSGCDLLCCGRGHRQESVQLEENCLCRFHWCCVVQ 317
Cdd:cd19337  220 RNSRFNKPTKDDLVYLDDSPDYCERNPKTGSLGTKGRECNKTSSGTDGCELLCCGRGYNTKKVEVVERCHCKFHWCCEVK 299
                        330
                 ....*....|...
gi 568906177 318 CHRCRVRKELSLC 330
Cdd:cd19337  300 CKTCEKIVDVHIC 312
Wnt_Wnt3_Wnt3a cd19335
Wnt domain found in proto-oncogene Wnt-3 and similar proteins; Wnt-3, also called ...
5-330 1.30e-103

Wnt domain found in proto-oncogene Wnt-3 and similar proteins; Wnt-3, also called proto-oncogene Int-4, functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. It is required for normal embryonic development, and especially for limb development. Wnt-3a functions in the canonical Wnt signaling pathway and plays crucial roles in both proliferation and differentiation processes in several types of stem cells. Wnt3a stimulates the migration and invasion of trophoblasts and induce the survival, proliferation, and migration of human embryonic kidney (HEK) 293 cells. It also up-regulates genes implicated in melanocyte differentiation and increases the expression and nuclear localization of the transcriptional co-activator with PDZ-binding motif (TAZ), a transcriptional modulator involved in activating osteoblastic differentiation. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381709  Cd Length: 314  Bit Score: 306.24  E-value: 1.30e-103
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177   5 SICRKARRLAGRQAELCQAEPEVVAELARGARLGVRECQFQFRFRRWNCSS--HSKA-FGRVLQQDIRETAFVFAITAAG 81
Cdd:cd19335    2 ILCGSIPGLVPKQLRFCRNYTELMPSVAEGAKLGIQECQHQFRGRRWNCTTieGDLSvFGPVLDKASRESAFVHAIASAG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177  82 ASHAVTQACSMGELLQCGCQApRGRAPPrpsgllgtpgppgptgspdaSAAWEWGGCGDDVDFGDEKSRLFMDAQHKRGR 161
Cdd:cd19335   82 VAHAVTRACAEGDSTSCGCDS-RHKGPP--------------------GEGWRWGGCSEDVEFGVRFSREFADARENRPD 140
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177 162 GdiRALVQLHNNEAGRLAVRSHTRTECKCHGLSGSCALRTCWQKLPPFREVGARLLERFHGAS--RVMGTNDGKA----L 235
Cdd:cd19335  141 A--RSAMNRHNNEAGRQAILDNMELKCKCHGLSGSCELKTCWWAQPDFRKIGDYLKDKYDSASemVVERHRESRGwvetL 218
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177 236 LPAVRTLKPPGRADLLYAADSPDFCAPNRRTGSPGTRGRACNSSAPDLSGCDLLCCGRGHRQESVQLEENCLCRFHWCCV 315
Cdd:cd19335  219 RPKYKLFKPPTERDLIYYEESPNFCEPNPETGSFGTRGRECNVTSHGIDGCDLLCCGRGYNTRTEKRTEKCHCIFVWCCY 298
                        330
                 ....*....|....*
gi 568906177 316 VQCHRCRVRKELSLC 330
Cdd:cd19335  299 VSCQECIRVYDVHTC 313
Wnt_Wnt16 cd19344
Wnt domain found in protein Wnt-16 and similar proteins; Wnt-16 is a mixed canonical and ...
13-330 2.52e-101

Wnt domain found in protein Wnt-16 and similar proteins; Wnt-16 is a mixed canonical and noncanonical Wnt ligand involved in the regulation of postnatal bone homeostasis. It promotes bone formation and inhibits bone resorption. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381718  Cd Length: 306  Bit Score: 300.30  E-value: 2.52e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177  13 LAGRQAELCQAEPEVVAELARGARLGVRECQFQFRFRRWNCSSHSK--AFGRVLQQDIRETAFVFAITAAGASHAVTQAC 90
Cdd:cd19344    1 LVSQQRRLCKKKPEAIPSVSEGARLGIYECQHQFRHERWNCSTTNDqnVFGKTLSRGTKETAFIYAITSAGVVHAVTRAC 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177  91 SMGELLQCGCQAPRGRapprpsgllgtpgppgptgsPDASAAWEWGGCGDDVDFGDEKSRLFMDA---QHKRGRGDIRAL 167
Cdd:cd19344   81 SAGNLTDCSCDSRRQG--------------------QSASEGWKWGGCSDNVDYGIWFARKFVDApekSERKRSRDVRSL 140
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177 168 VQLHNNEAGRLAVRSHTRTECKCHGLSGSCALRTCWQKLPPFREVGARLLERFHGASRVMGTNDGKALLPAVRTLK--PP 245
Cdd:cd19344  141 MNLHNNEVGRQAIARLMKVKCRCHGVSGSCEVKTCWKTMPSFEEVGDFLKQKYENSIQIATKKSKRRLRRRERRKRkvPI 220
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177 246 GRADLLYAADSPDFCAPNRRTGSPGTRGRACN--SSAPDlsGCDLLCCGRGHRQESVQLEENCLCRFHWCCVVQCHRCRV 323
Cdd:cd19344  221 SKDELVYIHKSPNYCVRDPKKGILGTSGRECNrtSTGPD--SCDLLCCGRGYNTQVVRHVERCNCKFVWCCYVKCKTCET 298

                 ....*..
gi 568906177 324 RKELSLC 330
Cdd:cd19344  299 MTDVHTC 305
Wnt_Wnt2b cd19346
Wnt domain found in protein Wnt-2b and similar proteins; Wnt-2b, also called protein Wnt-13, ...
6-330 1.72e-89

Wnt domain found in protein Wnt-2b and similar proteins; Wnt-2b, also called protein Wnt-13, functions in the canonical Wnt/beta-catenin signaling pathway. It plays a redundant role in embryonic lung development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381720  Cd Length: 314  Bit Score: 270.25  E-value: 1.72e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177   6 ICRKARRLAGRQAELCQAEPEVVAELARGARLGVRECQFQFRFRRWNCSSHSK---AFGRVLQQDIRETAFVFAITAAGA 82
Cdd:cd19346    5 ICDNIPGLVNKQRQLCQRHPDIMQSIGEGAKEWIRECQHQFRHHRWNCSTLDRdhtVFGRVMLRSSREAAFVYAISSAGV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177  83 SHAVTQACSMGELLQCGCQA-PRGRApprpsgllgtpgppgptgsPDASAAWEWGGCGDDVDFGDEKSRLFMDAQHKRGR 161
Cdd:cd19346   85 VYAITRACSQGELKSCSCDPhKRGRS-------------------HDERGEFDWGGCSDNINYGIKFAKAFVDAKEKKEK 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177 162 gDIRALVQLHNNEAGRLAVRSHTRTECKCHGLSGSCALRTCWQKLPPFREVGARLLERFHGASRVMGTNDGKALLPAVRT 241
Cdd:cd19346  146 -DARALMNLHNNRCGRMAVKRFMKLECKCHGVSGSCTLRTCWLAMSDFRKTGDYLRKRYNGAVQVTMNQDGTGFTVANKN 224
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177 242 LKPPGRADLLYAADSPDFCAPNRRTGSPGTRGRACNSSAPDLSGCDLLCCGRGHRQESVQLEENCLCRFHWCCVVQCHRC 321
Cdd:cd19346  225 FRKATKTDLVYFENSPDYCVMDKSAGSLGTAGRVCNKSSRGTDGCEVMCCGRGYDTTRVTRVTKCECKFHWCCAVRCKEC 304

                 ....*....
gi 568906177 322 RVRKELSLC 330
Cdd:cd19346  305 EETVDVHTC 313
Wnt_Wnt5a cd19347
Wnt domain found in protein Wnt-5a and similar proteins; Wnt-5a is a secreted growth factor ...
7-321 7.53e-88

Wnt domain found in protein Wnt-5a and similar proteins; Wnt-5a is a secreted growth factor that belongs to the noncanonical members of the Wingless-related MMTV-integration family. It can activate or inhibit canonical Wnt signaling, depending on receptor context. Wnt-5a specifically regulates dendritic spine formation in rodent hippocampal neurons, resulting in postsynaptic development that promotes the clustering of the postsynaptic density protein 95 (PSD-95). Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381721  Cd Length: 312  Bit Score: 266.16  E-value: 7.53e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177   7 CRKARRLAGRQAELCQAEPEVVAELARGARLGVRECQFQFRFRRWNCSS--HSKAFGRVLQQDIRETAFVFAITAAGASH 84
Cdd:cd19347    1 CSQLAGLSQGQKKLCQLYQDHMQYIGEGAKTGIKECQYQFRHRRWNCSTvdNTSVFGRVMQIGSRETAFTYAISAAGVVN 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177  85 AVTQACSMGELLQCGC-QAPRGRAPPRPsgllgtpgppgptgspdasaaWEWGGCGDDVDFGDEKSRLFMDAQ-----HK 158
Cdd:cd19347   81 AVSRACREGELSTCGCsRAARPKDLPRD---------------------WLWGGCGDNLEYGYRFAKEFVDARerekiYQ 139
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177 159 RGRGD-IRALVQLHNNEAGRLAVRSHTRTECKCHGLSGSCALRTCWQKLPPFREVGARLLERFHGASRVMGTNDGKaLLP 237
Cdd:cd19347  140 KGSYEsARTLMNLHNNEAGRRTVYNLADVACKCHGVSGSCSLKTCWLQLADFRKVGDALKEKYDSAAAMKLNSRGK-LVQ 218
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177 238 AVRTLKPPGRADLLYAADSPDFCAPNRRTGSPGTRGRACNSSAPDLSGCDLLCCGRGHRQESVQLEENCLCRFHWCCVVQ 317
Cdd:cd19347  219 VNSRFNPPTTLDLVYIDPSPDYCVRNESTGSLGTQGRLCNKTSEGMDGCELMCCGRGYDQFKTVQTERCHCKFHWCCYVK 298

                 ....
gi 568906177 318 CHRC 321
Cdd:cd19347  299 CKKC 302
Wnt_Wnt7a cd19349
Wnt domain found in protein Wnt-7a and similar proteins; Wnt-7a acts as a canonical Wnt ligand ...
6-330 8.42e-88

Wnt domain found in protein Wnt-7a and similar proteins; Wnt-7a acts as a canonical Wnt ligand that modulates the synaptic vesicle cycle and synaptic transmission in hippocampal neurons. It also plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381723  Cd Length: 318  Bit Score: 266.15  E-value: 8.42e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177   6 ICRKARRLAGRQAELCQAEPEVVAELARGARLGVRECQFQFRFRRWNCSS--HSKAFGRVLQQDIRETAFVFAITAAGAS 83
Cdd:cd19349    6 ICNKIPGLAPRQRAICQSRPDAIIVIGEGAQMGINECQFQFRNGRWNCSAlgERTVFGKELKVGSREAAFTYAIIAAGVA 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177  84 HAVTQACSMGELLQCGCQAPRgrapprpsgllgtpgppgpTGSPDASAAWEWGGCGDDVDFGDEKSRLFMDAqhKRGRGD 163
Cdd:cd19349   86 HAITAACTQGNLSDCGCDKEK-------------------QGQYNQEEGWKWGGCSADIRYGIGFSKVFVDA--REIKQN 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177 164 IRALVQLHNNEAGRLAVRSHTRTECKCHGLSGSCALRTCWQKLPPFREVGARLLERFHGASRVMGTNDGKALLPAVRTLK 243
Cdd:cd19349  145 ARTLMNLHNNEAGRKILEENMKLECKCHGVSGSCTTKTCWTTLPKFRELGYILKDKYNEAVHVEPVRASRNKRPTFLKIK 224
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177 244 P------PGRADLLYAADSPDFCAPNRRTGSPGTRGRACNSSAPDLSGCDLLCCGRGHRQESVQLEENCLCRFHWCCVVQ 317
Cdd:cd19349  225 KplsyrkPMDTDLVYIEKSPNYCEEDPVTGSVGTQGRMCNKTAQQNNGCDLMCCGRGYNTHQYSRVWQCNCKFHWCCYVK 304
                        330
                 ....*....|...
gi 568906177 318 CHRCRVRKELSLC 330
Cdd:cd19349  305 CNTCSERTEVYTC 317
Wnt_Wnt2 cd19345
Wnt domain found in protein Wnt-2 and similar proteins; Wnt-2, also called Int-1-like protein ...
6-330 1.07e-87

Wnt domain found in protein Wnt-2 and similar proteins; Wnt-2, also called Int-1-like protein 1 (INT1L1), or Int-1-related protein (IRP), functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. It plays an important role in embryonic lung development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381719  Cd Length: 314  Bit Score: 266.03  E-value: 1.07e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177   6 ICRKARRLAGRQAELCQAEPEVVAELARGARLGVRECQFQFRFRRWNCSSHSK---AFGRVLQQDIRETAFVFAITAAGA 82
Cdd:cd19345    5 MCDNIPGLVSRQRQLCHRHPEVMQAIGSGVKEWIAECQHQFRNHRWNCNTLDRdhsLFGRLLLRSSRESAFVYAISSAGV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177  83 SHAVTQACSMGELLQCGCQaPRGRAPPRpsgllgtpgppgptgspDASAAWEWGGCGDDVDFGDEKSRLFMDAQHKRGRg 162
Cdd:cd19345   85 VFAITRACSQGELKSCSCD-PKKKGSSK-----------------DSKGSFDWGGCSDNIDYGIRFARAFVDAKERKGK- 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177 163 DIRALVQLHNNEAGRLAVRSHTRTECKCHGLSGSCALRTCWQKLPPFREVGARLLERFHGASRVMGTNDGKALLPAVRTL 242
Cdd:cd19345  146 DARALMNLHNNRAGRKAVKRFMTLECKCHGVSGSCTVRTCWLAMADFRKTGDYLRKKYNGAIQVVMNQDGTGFTVANKHF 225
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177 243 KPPGRADLLYAADSPDFCAPNRRTGSPGTRGRACNSSAPDLSGCDLLCCGRGHRQESVQLEENCLCRFHWCCVVQCHRCR 322
Cdd:cd19345  226 KKPTKNDLVYFENSPDYCVRDRDAGSLGTAGRVCNRTSRGMDGCEVMCCGRGYDTSRVGRMTKCECKFHWCCAVRCKDCH 305

                 ....*...
gi 568906177 323 VRKELSLC 330
Cdd:cd19345  306 QQVDVHTC 313
Wnt_Wnt5b cd19348
Wnt domain found in protein Wnt-5b and similar proteins; Wnt-5b is a secreted growth factor ...
7-321 3.96e-85

Wnt domain found in protein Wnt-5b and similar proteins; Wnt-5b is a secreted growth factor that belongs to the noncanonical members of the Wingless-related MMTV-integration family. Its overexpression is associated with cancer aggressiveness. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381722  Cd Length: 312  Bit Score: 259.14  E-value: 3.96e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177   7 CRKARRLAGRQAELCQAEPEVVAELARGARLGVRECQFQFRFRRWNCSS--HSKAFGRVLQQDIRETAFVFAITAAGASH 84
Cdd:cd19348    1 CSQLTGLSPGQRKLCQLYQDHMVYIGEGAKTGIKECQYQFRQRRWNCSTvdNTSVFGRVMQIGSRETAFTYAVSAAGVVN 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177  85 AVTQACSMGELLQCGC-QAPRGRAPPRPsgllgtpgppgptgspdasaaWEWGGCGDDVDFGDEKSRLFMDAQHKRG--- 160
Cdd:cd19348   81 AISRACREGELSTCGCsRAARPKDLPRD---------------------WLWGGCGDNVEYGYRFAKEFVDAREREKnyp 139
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177 161 RGDI---RALVQLHNNEAGRLAVRSHTRTECKCHGLSGSCALRTCWQKLPPFREVGARLLERFHGASRVMGTNDGKALLP 237
Cdd:cd19348  140 KGSEehaRTLMNLQNNEAGRRAVYNLADVACKCHGVSGSCSLKTCWLQLADFRKVGDLLKEKYDSAAAMRINRKGKLELV 219
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177 238 AVRtLKPPGRADLLYAADSPDFCAPNRRTGSPGTRGRACNSSAPDLSGCDLLCCGRGHRQESVQLEENCLCRFHWCCVVQ 317
Cdd:cd19348  220 NSR-FNPPTAEDLVYIDPSPDYCLRNETTGSLGTQGRLCNKTSEGMDGCELMCCGRGYDQFKTVQVERCHCKFHWCCYVK 298

                 ....
gi 568906177 318 CHRC 321
Cdd:cd19348  299 CKKC 302
wnt_Wnt7b cd19350
Wnt domain found in protein Wnt-7b and similar proteins; Wnt-7b functions in the canonical Wnt ...
6-330 1.03e-84

Wnt domain found in protein Wnt-7b and similar proteins; Wnt-7b functions in the canonical Wnt/beta-catenin signaling pathway in vascular smooth muscle cells. It is required for normal fusion of the chorion and the allantois during placenta development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381724  Cd Length: 318  Bit Score: 258.40  E-value: 1.03e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177   6 ICRKARRLAGRQAELCQAEPEVVAELARGARLGVRECQFQFRFRRWNCSS--HSKAFGRVLQQDIRETAFVFAITAAGAS 83
Cdd:cd19350    6 ICNKIPGLAPRQRAICQSRPDAIIVIGEGAQMGINECQYQFRYGRWNCSAlgERTVFGQELRVGSREAAFTYAITAAGVA 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177  84 HAVTQACSMGELLQCGCQAPRgrapprpsgllgtpgppgpTGSPDASAAWEWGGCGDDVDFGDEKSRLFMDAqhKRGRGD 163
Cdd:cd19350   86 HAVTAACSQGNLSNCGCDREK-------------------QGYYNQEEGWKWGGCSADIKYGIDFSRKFVDA--REIKKN 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177 164 IRALVQLHNNEAGRLAVRSHTRTECKCHGLSGSCALRTCWQKLPPFREVGARLLERFHGASRVMGTNDGKALLPA----- 238
Cdd:cd19350  145 ARRLMNLHNNEAGRKVLEERMKLECKCHGVSGSCTTKTCWTTLPKFREIGYVLKEKYNAAVQVEVVRASRLRQPTflkik 224
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177 239 -VRTLKPPGRADLLYAADSPDFCAPNRRTGSPGTRGRACNSSAPDLSGCDLLCCGRGHRQESVQLEENCLCRFHWCCVVQ 317
Cdd:cd19350  225 kRRSYQKPMETDLVYIERSPNYCEEDAATGSVGTQGRLCNRTSPHTDGCDLMCCGRGYNTHQYTKVWQCNCKFHWCCFVK 304
                        330
                 ....*....|...
gi 568906177 318 CHRCRVRKELSLC 330
Cdd:cd19350  305 CNTCSERTEVFTC 317
Wnt_Wnt9 cd19341
Wnt domain found in protein Wnt-9a, Wnt-9b and similar proteins; The family includes Wnt-9a ...
13-330 1.77e-84

Wnt domain found in protein Wnt-9a, Wnt-9b and similar proteins; The family includes Wnt-9a and Wnt-9b, both of which function in the canonical Wnt/beta-catenin signaling pathway. Wnt-9a, also called protein Wnt-14, is required for normal timing of IHH expression during embryonic bone development, normal chondrocyte maturation and for normal bone mineralization during embryonic bone development. Wnt-9a plays a redundant role in maintaining joint integrity. It is a conserved regulator of hematopoietic stem and progenitor cell development. Wnt-9b, also called protein Wnt-14b, or protein Wnt-15, plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381715  Cd Length: 299  Bit Score: 257.22  E-value: 1.77e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177  13 LAGRQAELCQAEPEVVAELARGARLGVRECQFQFRFRRWNCSSHSKAFGrVLQQDIRETAFVFAITAAGASHAVTQACSM 92
Cdd:cd19341    1 LSRRQRRMCRRDPGLAETLLEAIRLSVLECQEQFRYERWNCSLGKYRIN-LLKKGYKETAFLYAISSAGLTHSVARACSS 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177  93 GELLQCGCqAPRGRApprpsgllgtpgppgptgsPDASAAWEWGGCGDDVDFGDEKSRLFMDAQHKRGRgDIRALVQLHN 172
Cdd:cd19341   80 GRLDRCTC-DESFSL-------------------EENRQTWLWGGCGDNIKYGKKFTRRFLQLKKKSGK-DLRAEIDRHN 138
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177 173 NEAGRLAVRSHTRTECKCHGLSGSCALRTCWQKLPPFREVGARLLERFHGASRVMGTNDG--------KALLPAVRTLKP 244
Cdd:cd19341  139 SEVGIRVVREGVKKTCKCHGVSGSCTVKTCWKQLAPFNEIGKILKRKYEKAVKVVSENNAatggsqlrKGKSGSVKKKSR 218
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177 245 PGRADLLYAADSPDFCAPNRRtgSPGTRGRACNSSApdlsGCDLLCCGRGHRQESVQLEENCLCRFHWCCVVQCHRCRVR 324
Cdd:cd19341  219 PRRKDLVYLEKSPSFCRSTRY--SPGTKGRRCLKGD----NCDTLCCGRGYNTQSEVVVKPCKCRVVWCCQVECKTCTER 292

                 ....*.
gi 568906177 325 KELSLC 330
Cdd:cd19341  293 EEIYTC 298
Wnt_Wnt8 cd19340
Wnt domain found in protein Wnt-8a, Wnt-8b and similar proteins; The family includes Wnt-8a ...
32-330 4.23e-83

Wnt domain found in protein Wnt-8a, Wnt-8b and similar proteins; The family includes Wnt-8a and Wnt-8b. Wnt-8a, also called protein Wnt-8d, plays a role in embryonic patterning. Wnt-8b may play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus. It acts as a suppressor of early eye and retinal progenitor formation. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381714  Cd Length: 301  Bit Score: 253.75  E-value: 4.23e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177  32 ARGARLGVRECQFQFRFRRWNCSSHSKAFGRVLQQDIRETAFVFAITAAGASHAVTQACSMGELLQCGCqaprgrAPPRP 111
Cdd:cd19340   14 AAGAQLAMEECQYQFKWDRWNCPESAFFSQKNNPSATRETAFVHAISSAGVMYTLTRNCSLGHFEGCGC------DDSKK 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177 112 SGLLgtpgppgptgspdaSAAWEWGGCGDDVDFGDEKSRLFMDAQHKRGrgDIRALVQLHNNEAGRLAVRSHTRTECKCH 191
Cdd:cd19340   88 GSKG--------------GEGWTWGGCSDNVKFGERVSKKFLDSLETGQ--DAQALMNLHNNRAGRKAVRKTMKKTCKCH 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177 192 GLSGSCALRTCWQKLPPFREVGARLLERFHGASRVMGTNDGKALLPAVRTLKPPG--RADLLYAADSPDFCAPNRRTGSP 269
Cdd:cd19340  152 GVSGSCSTQTCWMQLAPFREIGTDLKRKYDRAVRVDYENGGLRETNGSRAIKLLNikKNDLVYLEKSPNYCRANVTLGWP 231
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568906177 270 GTRGRAC------NSSAPDLSGCDLLC--CGRGHRQESVQLEENCLCRFHWCCVVQCHRCRVRKELSLC 330
Cdd:cd19340  232 GTLGRQCsrdkkeSVSRWERKSCRRLCraCGLKVRKKVVEVTSSCNCKFHWCCEVKCETCVELVIEYTC 300
Wnt_Wnt10a cd19355
Wnt domain found in protein Wnt-10a and similar proteins; Wnt-10a plays a role in normal ...
5-330 3.34e-82

Wnt domain found in protein Wnt-10a and similar proteins; Wnt-10a plays a role in normal ectoderm development. It is required for normal postnatal development and maintenance of tongue papillae and sweat ducts, as well as normal hair follicle function. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381729  Cd Length: 302  Bit Score: 251.44  E-value: 3.34e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177   5 SICRKARRLAGRQAELCQAEPEVVAELARGARLGVRECQFQFRFRRWNCSS---------HSKAFGRvlqqDIRETAFVF 75
Cdd:cd19355    2 TVCLTLPGLTRRQLEVCMRHPDVTASAIQGIQIAIHECQHQFRDHRWNCSSletrnkipyESVVFSR----GFRESAFAY 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177  76 AITAAGASHAVTQACSMGELLQCGCQaprgrapprpsgllgtpgppgptgspdasaaWEWGGCGDDVDFGDEKSRLFMDA 155
Cdd:cd19355   78 AIAAAGVVHAVSNACAMGKLKACGCD-------------------------------WEWGGCSPDVEYGERFSKDFLDS 126
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177 156 qhKRGRGDIRALVQLHNNEAGRLAVRSHTRTECKCHGLSGSCALRTCWQKLPPFREVGARLLERFHGAS--RVMGTNDGK 233
Cdd:cd19355  127 --RETYRDIHARMRLHNNRVGRQVVMDNMRRKCKCHGTSGSCQLKTCWQVTPEFRTVGSLLKDRFYVATliKPHNRNTGQ 204
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177 234 ALLPAVRTLKPPGRADLLYAADSPDFCAPNRRTGSPGTRGRACNSSAPDLSGCDLLCCGRGHRQESVQLEENCLCRFHWC 313
Cdd:cd19355  205 LEPGHAPHRRRASINDLVYFEKSPDFCEREPRLDSAGTQGRICNKTSPGMDNCESLCCGRGHNILRQTRSERCNCKFHWC 284
                        330
                 ....*....|....*..
gi 568906177 314 CVVQCHRCRVRKELSLC 330
Cdd:cd19355  285 CYVVCEECRITEWVSVC 301
Wnt_Wnt10b cd19356
Wnt domain found in protein Wnt-10b and similar proteins; Wnt-10b, also called protein Wnt-12, ...
5-330 1.78e-74

Wnt domain found in protein Wnt-10b and similar proteins; Wnt-10b, also called protein Wnt-12, specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. It is involved in signaling networks controlling stemness, pluripotency and cell fate decisions. Wnt-10b is unique and plays an important role in differentiation of epithelial cells in the hair follicle. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381730  Cd Length: 299  Bit Score: 231.70  E-value: 1.78e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177   5 SICRKARRLAGRQAELCQAEPEVVAELARGARLGVRECQFQFRFRRWNCSSHSKAfGRVLQQD------IRETAFVFAIT 78
Cdd:cd19356    2 TVCLTLPGLSKRQMGLCVRSPDVTASALQGIQIAIHECQHQLRDQRWNCSSLEGG-GKLPHDSailkrgFRESAFSFSLL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177  79 AAGASHAVTQACSMGELLQCGCqaprgrapprpsgllgtpgppgptgspdasaAWEWGGCGDDVDFGDEKSRLFMDAqhK 158
Cdd:cd19356   81 AAGVMHSVATACSLGKLRGCGC-------------------------------EWEWGGCSHDIEFGEKFSRDFLDS--R 127
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177 159 RGRGDIRALVQLHNNEAGRLAVRSHTRTECKCHGLSGSCALRTCWQKLPPFREVGARLLERFHGASRVMGTN-DGKALLP 237
Cdd:cd19356  128 ESPRDIQARMRIHNNRVGRQVVTENMKRKCKCHGTSGSCQFKTCWHVTPEFRLVGALLREKFQRAIFINSHNkNSGVFLP 207
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177 238 AVRTLKPPGraDLLYAADSPDFCAPNRRTGSPGTRGRACNSSAPDLSGCDLLCCGRGHRQESVQLEENCLCRFHWCCVVQ 317
Cdd:cd19356  208 RLRPRRLAR--ELVYFEKSPDFCERDPAVDSPGTQGRICNKTSPGMDGCGSLCCGRGHNILKQTRSERCHCRFHWCCYVL 285
                        330
                 ....*....|...
gi 568906177 318 CHRCRVRKELSLC 330
Cdd:cd19356  286 CEECRVTEWVNVC 298
Wnt_Wnt9b cd19354
Wnt domain found in protein Wnt-9b and similar proteins; Wnt-9b, also called protein Wnt-14b ...
13-330 2.06e-74

Wnt domain found in protein Wnt-9b and similar proteins; Wnt-9b, also called protein Wnt-14b or Wnt-15, functions in the canonical Wnt/beta-catenin signaling pathway. It plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381728  Cd Length: 297  Bit Score: 231.33  E-value: 2.06e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177  13 LAGRQAELCQAEPEVVAELARGARLGVRECQFQFRFRRWNCSSHSKafGRVLQQDIRETAFVFAITAAGASHAVTQACSM 92
Cdd:cd19354    1 LSRRQKRLCRREPGLAETLRDAVRLGLLECQFQFRSERWNCSLEGR--GSLLKRGFKETAFLYAVSSAALTHSLAKACSS 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177  93 GELLQCGCQAPRGrapprpsgllgtpgppgptgsPDASAAWEWGGCGDDVDFGDEKSRLFMdaQHKRGRGDIRALVQLHN 172
Cdd:cd19354   79 GRMERCTCDDSPG---------------------LENREAWQWGVCGDNLKYSTKFLKNFL--GQKKGSKDLRARVDAHN 135
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177 173 NEAGRLAVRSHTRTECKCHGLSGSCALRTCWQKLPPFREVGARLLERFHGASRVMG-TND--GKALLPAVRTLKP----- 244
Cdd:cd19354  136 TNVGIKAVKSGLKTTCKCHGVSGSCAVRTCWKQLSPFHETGRLLKLKYENAVKVHSvTNDatGETELWSPERHGHtlkgh 215
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177 245 -PGRADLLYAADSPDFCAPNRRtgSPGTRGRACNSSApdlsGCDLLCCGRGHRQESVQLEENCLCRFHWCCVVQCHRCRV 323
Cdd:cd19354  216 sPRSTDLVYLEDSPSFCRPSKY--SPGTAGRTCSRET----NCDSLCCGRGYNTQSRLVTFSCHCQVQWCCYVECQQCVQ 289

                 ....*..
gi 568906177 324 RKELSLC 330
Cdd:cd19354  290 EEEVYTC 296
Wnt_Wnt9a cd19353
Wnt domain found in protein Wnt-9a and similar proteins; Wnt-9a, also called protein Wnt-14, ...
13-330 3.71e-70

Wnt domain found in protein Wnt-9a and similar proteins; Wnt-9a, also called protein Wnt-14, functions in the canonical Wnt/beta-catenin signaling pathway. It is required for normal timing of IHH expression during embryonic bone development, normal chondrocyte maturation and for normal bone mineralization during embryonic bone development. Wnt-9a plays a redundant role in maintaining joint integrity. It is a conserved regulator of hematopoietic stem and progenitor cell development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381727  Cd Length: 298  Bit Score: 220.29  E-value: 3.71e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177  13 LAGRQAELCQAEPEVVAELARGARLGVRECQFQFRFRRWNCSSHSKAFGRVLQQDIRETAFVFAITAAGASHAVTQACSM 92
Cdd:cd19353    1 LERKQRRMCRRDPGVAETLMEAISMSALECQYQFRFERWNCTLEGRYRASLLKRGFKETAFLYAISSAGLTHAMAKACSA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177  93 GELLQCGC-QAPrgrapprpsgllgtpgppgptgSPDASAAWEWGGCGDDVDFGDEKSRLFMDaqhKRGRGDIRALVQLH 171
Cdd:cd19353   81 GRMERCTCdEAP----------------------DLENREAWQWGGCGDNLKYSNKFVKEFLG---RKSSKDLRARVDFH 135
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177 172 NNEAGRLAVRSHTRTECKCHGLSGSCALRTCWQKLPPFREVGARLLERFHGASRVMGTND---GKALLPAVRTLKP---- 244
Cdd:cd19353  136 NNLVGIKVIKAGVETTCKCHGVSGSCTVRTCWRQLSPFHEIGKQLKQKYETSLKVGSTTNeatGEGDISPPKKSGAghsd 215
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177 245 --PGRADLLYAADSPDFCAPNRRtgSPGTRGRACNSSapdlSGCDLLCCGRGHRQESVQLEENCLCRFHWCCVVQCHRCR 322
Cdd:cd19353  216 qiPRTTDLVYIDDSPSFCLMSRF--SPGTSGRRCYKD----KNCESICCGRGHNTQSRVVTRPCQCQVRWCCYVECKQCT 289

                 ....*...
gi 568906177 323 VRKELSLC 330
Cdd:cd19353  290 QREEVYTC 297
Wnt_Wnt8a cd19351
Wnt domain found in protein Wnt-8a and similar proteins; Wnt-8a, also called protein Wnt-8d, ...
29-322 2.37e-63

Wnt domain found in protein Wnt-8a and similar proteins; Wnt-8a, also called protein Wnt-8d, plays a role in embryonic patterning. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381725  Cd Length: 307  Bit Score: 203.21  E-value: 2.37e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177  29 AELARGARLGVRECQFQFRFRRWNC-------SSHSKafgrvLQQDIRETAFVFAITAAGASHAVTQACSMGELLQCGCQ 101
Cdd:cd19351   11 SSVAAGAQSGIEECKHQFAWERWNCpesalqlSTHNG-----LRSATRETSFVHAISSAGVMYTLTRNCSLGDFENCGCD 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177 102 APR-GRAPPRpsgllgtpgppgptgspdasaAWEWGGCGDDVDFGDEKSRLFMDAQHKRGrgDIRALVQLHNNEAGRLAV 180
Cdd:cd19351   86 DSRnGRTGGR---------------------GWIWGGCSDNVEFGERISKQFVDALETGQ--DARALMNLHNNEAGRLAV 142
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177 181 RSHTRTECKCHGLSGSCALRTCWQKLPPFREVGARLLERFHGA-------SRVMGTNDGKALLPAVRTLKPPGRADLLYA 253
Cdd:cd19351  143 KATMKRTCKCHGVSGSCSIQTCWLQLADFREIGNYLKVKHDQAlklemdkRRMRAGNSADNRGAIAEAFGSVAETELIYL 222
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568906177 254 ADSPDFCAPNRRTGSPGTRGRACNSSAPDLS-----GCDLLC--CGRGHRQESVQLEENCLCRFHWCCVVQCHRCR 322
Cdd:cd19351  223 EDSPDYCTKNASLGLQGTEGRECLQSGKNLSqwerrSCRRLCteCGLRVEERRTEVVSSCNCKFHWCCTVKCEQCR 298
Wnt_Wnt8b cd19352
Wnt domain found in protein Wnt-8b and similar proteins; Wnt-8b may play an important role in ...
29-330 5.53e-63

Wnt domain found in protein Wnt-8b and similar proteins; Wnt-8b may play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus. It acts as a suppressor of early eye and retinal progenitor formation. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381726  Cd Length: 305  Bit Score: 202.17  E-value: 5.53e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177  29 AELARGARLGVRECQFQFRFRRWNC-------SSHSKafgrvLQQDIRETAFVFAITAAGASHAVTQACSMGELLQCGCQ 101
Cdd:cd19352   12 SSVAAGAQSGIEECKYQFAWDRWNCperalqlSSHSG-----LRSANRETAFVHAISSAGVMYTLTRNCSLGDFDNCGCD 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177 102 APRGrapprpsgllgtpgppgptgSPDASAAWEWGGCGDDVDFGDEKSRLFMDAQHKRGrgDIRALVQLHNNEAGRLAVR 181
Cdd:cd19352   87 DSRN--------------------GQLGGQGWLWGGCSDNVGFGEAISKQFVDALETGQ--DARAAMNLHNNEAGRKAVK 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177 182 SHTRTECKCHGLSGSCALRTCWQKLPPFREVGARLLERFHGASRV---MGTNDGKALLPAV-RTLKPPGRADLLYAADSP 257
Cdd:cd19352  145 GTMKRTCKCHGVSGSCTTQTCWLQLPEFREVGNYLKEKYHRALKVdllQGAGNSAASRGAIaETFRSISKKELVHLEDSP 224
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568906177 258 DFCAPNRRTGSPGTRGRACNSSAPDLS-----GCDLLC--CGRGHRQESVQLEENCLCRFHWCCVVQCHRCRVRKELSLC 330
Cdd:cd19352  225 DYCLENKTLGLLGTEGRECLKRGKALSkwekrSCRRLCgdCGLAVEERRAEMVSSCNCKFHWCCAVKCEQCRKTVTKYFC 304
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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