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transcription elongation factor A N-terminal and central domain-containing protein 2 isoform X1 [Mus musculus]
List of domain hits
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Name | Accession | Description | Interval | E-value | |||
TFIIS_I | cd00183 | N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a ... |
38-111 | 2.72e-18 | |||
N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme : Pssm-ID: 238107 Cd Length: 76 Bit Score: 75.42 E-value: 2.72e-18
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TFIIS_M super family | cl47972 | Transcription factor S-II (TFIIS), central domain; Transcription elongation by RNA polymerase ... |
126-202 | 3.29e-03 | |||
Transcription factor S-II (TFIIS), central domain; Transcription elongation by RNA polymerase II is regulated by the general elongation factor TFIIS. This factor stimulates RNA polymerase II to transcribe through regions of DNA that promote the formation of stalled ternary complexes. TFIIS is composed of three structural domains, termed I, II, and III. The two C-terminal domains (II and III), this domain and pfam01096 are required for transcription activity. The actual alignment was detected with superfamily member pfam07500: Pssm-ID: 462184 Cd Length: 112 Bit Score: 36.03 E-value: 3.29e-03
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Name | Accession | Description | Interval | E-value | |||
TFIIS_I | cd00183 | N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a ... |
38-111 | 2.72e-18 | |||
N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme Pssm-ID: 238107 Cd Length: 76 Bit Score: 75.42 E-value: 2.72e-18
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Med26 | pfam08711 | TFIIS helical bundle-like domain; Mediator is a large complex of up to 33 proteins that is ... |
60-110 | 3.85e-11 | |||
TFIIS helical bundle-like domain; Mediator is a large complex of up to 33 proteins that is conserved from plants to fungi to humans - the number and representation of individual subunits varying with species {1-2]. It is arranged into four different sections, a core, a head, a tail and a kinase-activity part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function. Mediator exists in two major forms in human cells: a smaller form that interacts strongly with pol II and activates transcription, and a large form that does not interact strongly with pol II and does not directly activate transcription. Notably, the 'small' and 'large' Mediator complexes differ in their subunit composition: the Med26 subunit preferentially associates with the small, active complex, whereas cdk8, cyclin C, Med12 and Med13 associate with the large Mediator complex. This family includesthe C terminal region of a number of eukaryotic hypothetical proteins which are homologous to the Saccharomyces cerevisiae protein IWS1. IWS1 is known to be an Pol II transcription elongation factor and interacts with Spt6 and Spt5. Pssm-ID: 462573 [Multi-domain] Cd Length: 52 Bit Score: 55.98 E-value: 3.85e-11
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TFS2N | smart00509 | Domain in the N-terminus of transcription elongation factor S-II (and elsewhere); |
56-112 | 1.63e-07 | |||
Domain in the N-terminus of transcription elongation factor S-II (and elsewhere); Pssm-ID: 197766 [Multi-domain] Cd Length: 75 Bit Score: 46.92 E-value: 1.63e-07
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TFSII | TIGR01385 | transcription elongation factor S-II; This model represents eukaryotic transcription ... |
61-112 | 4.93e-07 | |||
transcription elongation factor S-II; This model represents eukaryotic transcription elongation factor S-II. This protein allows stalled RNA transcription complexes to perform a cleavage of the nascent RNA and restart at the newly generated 3-prime end. Pssm-ID: 273592 [Multi-domain] Cd Length: 299 Bit Score: 49.07 E-value: 4.93e-07
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TFIIS_M | pfam07500 | Transcription factor S-II (TFIIS), central domain; Transcription elongation by RNA polymerase ... |
126-202 | 3.29e-03 | |||
Transcription factor S-II (TFIIS), central domain; Transcription elongation by RNA polymerase II is regulated by the general elongation factor TFIIS. This factor stimulates RNA polymerase II to transcribe through regions of DNA that promote the formation of stalled ternary complexes. TFIIS is composed of three structural domains, termed I, II, and III. The two C-terminal domains (II and III), this domain and pfam01096 are required for transcription activity. Pssm-ID: 462184 Cd Length: 112 Bit Score: 36.03 E-value: 3.29e-03
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Name | Accession | Description | Interval | E-value | |||
TFIIS_I | cd00183 | N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a ... |
38-111 | 2.72e-18 | |||
N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme Pssm-ID: 238107 Cd Length: 76 Bit Score: 75.42 E-value: 2.72e-18
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Med26 | pfam08711 | TFIIS helical bundle-like domain; Mediator is a large complex of up to 33 proteins that is ... |
60-110 | 3.85e-11 | |||
TFIIS helical bundle-like domain; Mediator is a large complex of up to 33 proteins that is conserved from plants to fungi to humans - the number and representation of individual subunits varying with species {1-2]. It is arranged into four different sections, a core, a head, a tail and a kinase-activity part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function. Mediator exists in two major forms in human cells: a smaller form that interacts strongly with pol II and activates transcription, and a large form that does not interact strongly with pol II and does not directly activate transcription. Notably, the 'small' and 'large' Mediator complexes differ in their subunit composition: the Med26 subunit preferentially associates with the small, active complex, whereas cdk8, cyclin C, Med12 and Med13 associate with the large Mediator complex. This family includesthe C terminal region of a number of eukaryotic hypothetical proteins which are homologous to the Saccharomyces cerevisiae protein IWS1. IWS1 is known to be an Pol II transcription elongation factor and interacts with Spt6 and Spt5. Pssm-ID: 462573 [Multi-domain] Cd Length: 52 Bit Score: 55.98 E-value: 3.85e-11
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TFS2N | smart00509 | Domain in the N-terminus of transcription elongation factor S-II (and elsewhere); |
56-112 | 1.63e-07 | |||
Domain in the N-terminus of transcription elongation factor S-II (and elsewhere); Pssm-ID: 197766 [Multi-domain] Cd Length: 75 Bit Score: 46.92 E-value: 1.63e-07
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TFSII | TIGR01385 | transcription elongation factor S-II; This model represents eukaryotic transcription ... |
61-112 | 4.93e-07 | |||
transcription elongation factor S-II; This model represents eukaryotic transcription elongation factor S-II. This protein allows stalled RNA transcription complexes to perform a cleavage of the nascent RNA and restart at the newly generated 3-prime end. Pssm-ID: 273592 [Multi-domain] Cd Length: 299 Bit Score: 49.07 E-value: 4.93e-07
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TFIIS_M | pfam07500 | Transcription factor S-II (TFIIS), central domain; Transcription elongation by RNA polymerase ... |
126-202 | 3.29e-03 | |||
Transcription factor S-II (TFIIS), central domain; Transcription elongation by RNA polymerase II is regulated by the general elongation factor TFIIS. This factor stimulates RNA polymerase II to transcribe through regions of DNA that promote the formation of stalled ternary complexes. TFIIS is composed of three structural domains, termed I, II, and III. The two C-terminal domains (II and III), this domain and pfam01096 are required for transcription activity. Pssm-ID: 462184 Cd Length: 112 Bit Score: 36.03 E-value: 3.29e-03
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Blast search parameters | ||||
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