|
Name |
Accession |
Description |
Interval |
E-value |
| PLN00206 |
PLN00206 |
DEAD-box ATP-dependent RNA helicase; Provisional |
70-550 |
9.93e-162 |
|
DEAD-box ATP-dependent RNA helicase; Provisional
Pssm-ID: 215103 [Multi-domain] Cd Length: 518 Bit Score: 471.58 E-value: 9.93e-162
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 70 AEVSSTGPDEGvkdshpseEPVKSFSKTQRWPEPGEPVCVVCGRYGEYICDKTDEDVCSLECKAKHLLQVKEGEGSLRPS 149
Cdd:PLN00206 1 MNEEGCNPHED--------DVVKERSIEQREALPGEPKCVVCGRYGEYICDETDDDICSLECKQALLRRVAKSRVAVGAP 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 150 SPQRVAAEPESpldaFYVyKEHPFIVTLKEDQIETLKQQLGISVQGQDVARPIIDFEHCGFPETLNQNLKKSGYEVPTPI 229
Cdd:PLN00206 73 KPKRLPATDEC----FYV-RDPGSTSGLSSSQAELLRRKLEIHVKGEAVPPPILSFSSCGLPPKLLLNLETAGYEFPTPI 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 230 QMQMIPVGLLGRDILASADTGSGKTAAFLLPVIIRA-------FSEDKTPSALILTPTRELAIQIERQAKELMSGLPrMK 302
Cdd:PLN00206 148 QMQAIPAALSGRSLLVSADTGSGKTASFLVPIISRCctirsghPSEQRNPLAMVLTPTRELCVQVEDQAKVLGKGLP-FK 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 303 TVLLVGGLPLPPQLYRLRQHVKVIIATPGRLLDIIKQSSVSLSGIKIVVVDEADTMLKMGFQQQVLDVLEHTPGDcQTIL 382
Cdd:PLN00206 227 TALVVGGDAMPQQLYRIQQGVELIVGTPGRLIDLLSKHDIELDNVSVLVLDEVDCMLERGFRDQVMQIFQALSQP-QVLL 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 383 VSATIPDSIEQLTDQLLHNPVRIITGDKNLPCASVRQIILWVEDPAKKKKLFEILNDQKLFKPPVLVFVDCKLGADLLSE 462
Cdd:PLN00206 306 FSATVSPEVEKFASSLAKDIILISIGNPNRPNKAVKQLAIWVETKQKKQKLFDILKSKQHFKPPAVVFVSSRLGADLLAN 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 463 AVQKITGLNSTSIHSEKSQVERRDILK-------------------------------------------VGRVGRLGQN 499
Cdd:PLN00206 386 AITVVTGLKALSIHGEKSMKERREVMKsflvgevpvivatgvlgrgvdllrvrqviifdmpntikeyihqIGRASRMGEK 465
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|..
gi 568909597 500 GTAITFINNNSKRLFWDVAKRVKPTGSILPPQLLNSPYL-HEQKRKEQQKDR 550
Cdd:PLN00206 466 GTAIVFVNEEDRNLFPELVALLKSSGAAIPRELANSRYLgSGRKRKKKRRYG 517
|
|
| DEADc_DDX59 |
cd17962 |
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer ... |
214-406 |
3.65e-117 |
|
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer development by promoting DNA replication. DDX59 knockdown mice showed reduced cell proliferation, anchorage-independent cell growth, and reduction of tumor formation. Recent work shows that EGFR and Ras regulate DDX59 during lung cancer development. Diseases associated with DDX59 (also called zinc finger HIT domain-containing protein 5) include orofaciodigital syndrome V and orofaciodigital syndrome. DDX59 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350720 [Multi-domain] Cd Length: 193 Bit Score: 345.30 E-value: 3.65e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 214 LNQNLKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIIRAFSEDKTPSALILTPTRELAIQIERQAKE 293
Cdd:cd17962 1 LSSNLKKAGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIIRCLTEHRNPSALILTPTRELAVQIEDQAKE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 294 LMSGLPRMKTVLLVGGLPLPPQLYRLRQHVKVIIATPGRLLDIIKQSSVSLSGIKIVVVDEADTMLKMGFQQQVLDVLEH 373
Cdd:cd17962 81 LMKGLPPMKTALLVGGLPLPPQLYRLQQGVKVIIATPGRLLDILKQSSVELDNIKIVVVDEADTMLKMGFQQQVLDILEN 160
|
170 180 190
....*....|....*....|....*....|...
gi 568909597 374 TPGDCQTILVSATIPDSIEQLTDQLLHNPVRII 406
Cdd:cd17962 161 ISHDHQTILVSATIPRGIEQLAGQLLQNPVRIT 193
|
|
| SrmB |
COG0513 |
Superfamily II DNA and RNA helicase [Replication, recombination and repair]; |
205-550 |
7.10e-105 |
|
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
Pssm-ID: 440279 [Multi-domain] Cd Length: 420 Bit Score: 322.10 E-value: 7.10e-105
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 205 FEHCGFPETLNQNLKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIIR-AFSEDKTPSALILTPTREL 283
Cdd:COG0513 4 FADLGLSPPLLKALAELGYTTPTPIQAQAIPLILAGRDVLGQAQTGTGKTAAFLLPLLQRlDPSRPRAPQALILAPTREL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 284 AIQIERQAKELMSGLPrMKTVLLVGGLPLPPQLYRLRQHVKVIIATPGRLLDIIKQSSVSLSGIKIVVVDEADTMLKMGF 363
Cdd:COG0513 84 ALQVAEELRKLAKYLG-LRVATVYGGVSIGRQIRALKRGVDIVVATPGRLLDLIERGALDLSGVETLVLDEADRMLDMGF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 364 QQQVLDVLEHTPGDCQTILVSATIPDSIEQLTDQLLHNPVRIITGDKNLPCASVRQIILWVEDPAKKKKLFEILNDQKLF 443
Cdd:COG0513 163 IEDIERILKLLPKERQTLLFSATMPPEIRKLAKRYLKNPVRIEVAPENATAETIEQRYYLVDKRDKLELLRRLLRDEDPE 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 444 KppVLVFVDCKLGADLLSEAVQKiTGLNSTSIHSEKSQVERRDILK---------------------------------- 489
Cdd:COG0513 243 R--AIVFCNTKRGADRLAEKLQK-RGISAAALHGDLSQGQRERALDafrngkirvlvatdvaargididdvshvinydlp 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 490 ---------VGRVGRLGQNGTAITFINNNSKRLFWDVAKRvkpTGSILPPQLLNSPYLHEQKRKEQQKDR 550
Cdd:COG0513 320 edpedyvhrIGRTGRAGAEGTAISLVTPDERRLLRAIEKL---IGQKIEEEELPGFEPVEEKRLERLKPK 386
|
|
| DEADc |
cd00268 |
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family ... |
214-405 |
4.56e-85 |
|
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350669 [Multi-domain] Cd Length: 196 Bit Score: 262.76 E-value: 4.56e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 214 LNQNLKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIIR----AFSEDKTPSALILTPTRELAIQIER 289
Cdd:cd00268 1 LLKALKKLGFEKPTPIQAQAIPLILSGRDVIGQAQTGSGKTLAFLLPILEKllpePKKKGRGPQALVLAPTRELAMQIAE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 290 QAKELMSGlPRMKTVLLVGGLPLPPQLYRLRQHVKVIIATPGRLLDIIKQSSVSLSGIKIVVVDEADTMLKMGFQQQVLD 369
Cdd:cd00268 81 VARKLGKG-TGLKVAAIYGGAPIKKQIEALKKGPDIVVGTPGRLLDLIERGKLDLSNVKYLVLDEADRMLDMGFEEDVEK 159
|
170 180 190
....*....|....*....|....*....|....*.
gi 568909597 370 VLEHTPGDCQTILVSATIPDSIEQLTDQLLHNPVRI 405
Cdd:cd00268 160 ILSALPKDRQTLLFSATLPEEVKELAKKFLKNPVRI 195
|
|
| PTZ00110 |
PTZ00110 |
helicase; Provisional |
168-547 |
7.27e-74 |
|
helicase; Provisional
Pssm-ID: 240273 [Multi-domain] Cd Length: 545 Bit Score: 245.45 E-value: 7.27e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 168 YKEHPFIVTLKEDQIETLKQQLGIS-VQGQDVARPIIDFEHCGFPETLNQNLKKSGYEVPTPIQMQMIPVGLLGRDILAS 246
Cdd:PTZ00110 94 YKEHPEVSALSSKEVDEIRKEKEITiIAGENVPKPVVSFEYTSFPDYILKSLKNAGFTEPTPIQVQGWPIALSGRDMIGI 173
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 247 ADTGSGKTAAFLLPVIIRAFSEDKT-----PSALILTPTRELAIQIERQAKELmSGLPRMKTVLLVGGLPLPPQLYRLRQ 321
Cdd:PTZ00110 174 AETGSGKTLAFLLPAIVHINAQPLLrygdgPIVLVLAPTRELAEQIREQCNKF-GASSKIRNTVAYGGVPKRGQIYALRR 252
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 322 HVKVIIATPGRLLDIIKQSSVSLSGIKIVVVDEADTMLKMGFQQQVLDVLEHTPGDCQTILVSATIPDSIEQLTDQLL-H 400
Cdd:PTZ00110 253 GVEILIACPGRLIDFLESNVTNLRRVTYLVLDEADRMLDMGFEPQIRKIVSQIRPDRQTLMWSATWPKEVQSLARDLCkE 332
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 401 NPVRIITGDKNL-PCASVRQIILWVEDPAKKKKLFEILndQKLFKP--PVLVFVDCKLGADLLSEAVqKITGLNSTSIHS 477
Cdd:PTZ00110 333 EPVHVNVGSLDLtACHNIKQEVFVVEEHEKRGKLKMLL--QRIMRDgdKILIFVETKKGADFLTKEL-RLDGWPALCIHG 409
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 478 EKSQVERRDIL-------------------------------------------KVGRVGRLGQNGTAITFINNNSKRLF 514
Cdd:PTZ00110 410 DKKQEERTWVLnefktgkspimiatdvasrgldvkdvkyvinfdfpnqiedyvhRIGRTGRAGAKGASYTFLTPDKYRLA 489
|
410 420 430
....*....|....*....|....*....|...
gi 568909597 515 WDVAKRVKPTGSILPPQLLNSPYLHEQKRKEQQ 547
Cdd:PTZ00110 490 RDLVKVLREAKQPVPPELEKLSNERSNGTERRR 522
|
|
| DEADc_DDX3_DDX4 |
cd17967 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes ... |
205-401 |
3.57e-68 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes Drosophila melanogaster Vasa, which is essential for development. DEAD box protein 3 (DDX3) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DDX3 and DDX4 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350725 [Multi-domain] Cd Length: 221 Bit Score: 220.05 E-value: 3.57e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 205 FEHCGFPETLNQNLKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVI----------IRAFSEDKTPSA 274
Cdd:cd17967 2 FEEAGLRELLLENIKRAGYTKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPIIsklledgppsVGRGRRKAYPSA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 275 LILTPTRELAIQIERQAKELMSGLPrMKTVLLVGGLPLPPQLYRLRQHVKVIIATPGRLLDIIKQSSVSLSGIKIVVVDE 354
Cdd:cd17967 82 LILAPTRELAIQIYEEARKFSYRSG-VRSVVVYGGADVVHQQLQLLRGCDILVATPGRLVDFIERGRISLSSIKFLVLDE 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 568909597 355 ADTMLKMGFQQQVLDVLEHT----PGDCQTILVSATIPDSIEQLTDQLLHN 401
Cdd:cd17967 161 ADRMLDMGFEPQIRKIVEHPdmppKGERQTLMFSATFPREIQRLAADFLKN 211
|
|
| DEADc_DDX27 |
cd17947 |
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ... |
222-405 |
7.16e-64 |
|
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ribosomal subunits protein 1 homolog, and probable ATP-dependent RNA helicase DDX27) is involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. DDX27 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350705 [Multi-domain] Cd Length: 196 Bit Score: 207.88 E-value: 7.16e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 222 GYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVI---IRAFSEDKTPSALILTPTRELAIQIERQAKELMSGL 298
Cdd:cd17947 9 GFTKPTPIQAAAIPLALLGKDICASAVTGSGKTAAFLLPILerlLYRPKKKAATRVLVLVPTRELAMQCFSVLQQLAQFT 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 299 PrMKTVLLVGGLPLPPQLYRLRQHVKVIIATPGRLLDIIKQS-SVSLSGIKIVVVDEADTMLKMGFQQQVLDVLEHTPGD 377
Cdd:cd17947 89 D-ITFALAVGGLSLKAQEAALRARPDIVIATPGRLIDHLRNSpSFDLDSIEILVLDEADRMLEEGFADELKEILRLCPRT 167
|
170 180
....*....|....*....|....*...
gi 568909597 378 CQTILVSATIPDSIEQLTDQLLHNPVRI 405
Cdd:cd17947 168 RQTMLFSATMTDEVKDLAKLSLNKPVRV 195
|
|
| DEADc_DDX4 |
cd18052 |
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA ... |
191-400 |
2.22e-61 |
|
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DEAD-box helicases are a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350810 [Multi-domain] Cd Length: 264 Bit Score: 203.66 E-value: 2.22e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 191 ISVQGQDVARPIIDFEHCGFPETLNQNLKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIIR------ 264
Cdd:cd18052 31 VEVTGRNPPPAILTFEEANLCETLLKNIRKAGYEKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPVLTGmmkegl 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 265 ---AFSEDKTPSALILTPTRELAIQIERQAKELMSGLPrMKTVLLVGGLPLPPQLYRLRQHVKVIIATPGRLLDIIKQSS 341
Cdd:cd18052 111 tasSFSEVQEPQALIVAPTRELANQIFLEARKFSYGTC-IRPVVVYGGVSVGHQIRQIEKGCHILVATPGRLLDFIGRGK 189
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568909597 342 VSLSGIKIVVVDEADTMLKMGFQQQVLDVLEH----TPGDCQTILVSATIPDSIEQLTDQLLH 400
Cdd:cd18052 190 ISLSKLKYLILDEADRMLDMGFGPEIRKLVSEpgmpSKEDRQTLMFSATFPEEIQRLAAEFLK 252
|
|
| PRK10590 |
PRK10590 |
ATP-dependent RNA helicase RhlE; Provisional |
205-484 |
1.09e-60 |
|
ATP-dependent RNA helicase RhlE; Provisional
Pssm-ID: 236722 [Multi-domain] Cd Length: 456 Bit Score: 207.74 E-value: 1.09e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 205 FEHCGFPETLNQNLKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIIRAFSEDKTPS------ALILT 278
Cdd:PRK10590 3 FDSLGLSPDILRAVAEQGYREPTPIQQQAIPAVLEGRDLMASAQTGTGKTAGFTLPLLQHLITRQPHAKgrrpvrALILT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 279 PTRELAIQIERQAKELMSGLpRMKTVLLVGGLPLPPQLYRLRQHVKVIIATPGRLLDIIKQSSVSLSGIKIVVVDEADTM 358
Cdd:PRK10590 83 PTRELAAQIGENVRDYSKYL-NIRSLVVFGGVSINPQMMKLRGGVDVLVATPGRLLDLEHQNAVKLDQVEILVLDEADRM 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 359 LKMGFQQQVLDVLEHTPGDCQTILVSATIPDSIEQLTDQLLHNPVRIITGDKNLPCASVRQIILWVeDPAKKKKLFEIL- 437
Cdd:PRK10590 162 LDMGFIHDIRRVLAKLPAKRQNLLFSATFSDDIKALAEKLLHNPLEIEVARRNTASEQVTQHVHFV-DKKRKRELLSQMi 240
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 568909597 438 ---NDQKlfkppVLVFVDCKLGADLLSEAVQKiTGLNSTSIHSEKSQVER 484
Cdd:PRK10590 241 gkgNWQQ-----VLVFTRTKHGANHLAEQLNK-DGIRSAAIHGNKSQGAR 284
|
|
| DEADc_DDX52 |
cd17957 |
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ... |
214-408 |
1.60e-60 |
|
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ubiquitously expressed in testis, endometrium, and other tissues in humans. DDX52 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350715 [Multi-domain] Cd Length: 198 Bit Score: 198.97 E-value: 1.60e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 214 LNQNLKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVI--IRAFSEDKTPSALILTPTRELAIQIERQA 291
Cdd:cd17957 1 LLNNLEESGYREPTPIQMQAIPILLHGRDLLACAPTGSGKTLAFLIPILqkLGKPRKKKGLRALILAPTRELASQIYREL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 292 KELMSGLPrMKTVLLVGGL-PLPPQLYRLRQHVKVIIATPGRLLDIIKQSSVSLSGIKIVVVDEADTMLKMGFQQQVLDV 370
Cdd:cd17957 81 LKLSKGTG-LRIVLLSKSLeAKAKDGPKSITKYDILVSTPLRLVFLLKQGPIDLSSVEYLVLDEADKLFEPGFREQTDEI 159
|
170 180 190
....*....|....*....|....*....|....*....
gi 568909597 371 LEHTPGDC-QTILVSATIPDSIEQLTDQLLHNPVRIITG 408
Cdd:cd17957 160 LAACTNPNlQRSLFSATIPSEVEELARSVMKDPIRIIVG 198
|
|
| PRK11776 |
PRK11776 |
ATP-dependent RNA helicase DbpA; Provisional |
211-507 |
2.89e-60 |
|
ATP-dependent RNA helicase DbpA; Provisional
Pssm-ID: 236977 [Multi-domain] Cd Length: 460 Bit Score: 206.96 E-value: 2.89e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 211 PETLnQNLKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVI----IRAFSedktPSALILTPTRELAIQ 286
Cdd:PRK11776 13 PALL-ANLNELGYTEMTPIQAQSLPAILAGKDVIAQAKTGSGKTAAFGLGLLqkldVKRFR----VQALVLCPTRELADQ 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 287 IERQAKELMSGLPRMKTVLLVGGLPLPPQLYRLRQHVKVIIATPGRLLDIIKQSSVSLSGIKIVVVDEADTMLKMGFQQQ 366
Cdd:PRK11776 88 VAKEIRRLARFIPNIKVLTLCGGVPMGPQIDSLEHGAHIIVGTPGRILDHLRKGTLDLDALNTLVLDEADRMLDMGFQDA 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 367 VLDVLEHTPGDCQTILVSATIPDSIEQLTDQLLHNPVRIITGDKNlpcasvrqiilwvEDPAKKKKLFEILNDQKL---- 442
Cdd:PRK11776 168 IDAIIRQAPARRQTLLFSATYPEGIAAISQRFQRDPVEVKVESTH-------------DLPAIEQRFYEVSPDERLpalq 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 443 -----FKP-PVLVF----VDCKLGADLLSEAvqkitGLNSTSIHSEKSQVERRDIL------------------------ 488
Cdd:PRK11776 235 rlllhHQPeSCVVFcntkKECQEVADALNAQ-----GFSALALHGDLEQRDRDQVLvrfanrscsvlvatdvaargldik 309
|
330 340 350
....*....|....*....|....*....|....*...
gi 568909597 489 -------------------KVGRVGRLGQNGTAITFIN 507
Cdd:PRK11776 310 aleavinyelardpevhvhRIGRTGRAGSKGLALSLVA 347
|
|
| DEADc_DDX54 |
cd17959 |
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner ... |
205-405 |
6.37e-59 |
|
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. DDX54 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350717 [Multi-domain] Cd Length: 205 Bit Score: 195.22 E-value: 6.37e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 205 FEHCGFPETLNQNLKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVI--IRAFSEDKTPSALILTPTRE 282
Cdd:cd17959 3 FQSMGLSPPLLRAIKKKGYKVPTPIQRKTIPLILDGRDVVAMARTGSGKTAAFLIPMIekLKAHSPTVGARALILSPTRE 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 283 LAIQIERQAKELMSGLpRMKTVLLVGGLPLPPQLYRLRQHVKVIIATPGRLLDIIKQSSVSLSGIKIVVVDEADTMLKMG 362
Cdd:cd17959 83 LALQTLKVTKELGKFT-DLRTALLVGGDSLEEQFEALASNPDIIIATPGRLLHLLVEMNLKLSSVEYVVFDEADRLFEMG 161
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 568909597 363 FQQQVLDVLEHTPGDCQTILVSATIPDSIEQLTDQLLHNPVRI 405
Cdd:cd17959 162 FAEQLHEILSRLPENRQTLLFSATLPKLLVEFAKAGLNEPVLI 204
|
|
| DEADc_DDX46 |
cd17953 |
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) ... |
192-406 |
1.43e-58 |
|
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) is a component of the 17S U2 snRNP complex. It plays an important role in pre-mRNA splicing and has a role in antiviral innate immunity. DDX46 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350711 [Multi-domain] Cd Length: 222 Bit Score: 194.90 E-value: 1.43e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 192 SVQGQDVARPIIDFEHCGFPETLNQNLKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVI-----IRAF 266
Cdd:cd17953 1 KVRGKDCPKPIQKWSQCGLSEKVLDLIKKLGYEKPTPIQAQALPAIMSGRDVIGIAKTGSGKTLAFLLPMFrhikdQRPV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 267 SEDKTPSALILTPTRELAIQIERQAKELMSGLpRMKTVLLVGGLPLPPQLYRLRQHVKVIIATPGRLLDIIKQSS---VS 343
Cdd:cd17953 81 KPGEGPIGLIMAPTRELALQIYVECKKFSKAL-GLRVVCVYGGSGISEQIAELKRGAEIVVCTPGRMIDILTANNgrvTN 159
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568909597 344 LSGIKIVVVDEADTMLKMGFQQQVLDVLEHTPGDCQTILVSATIPDSIEQLTDQLLHNPVRII 406
Cdd:cd17953 160 LRRVTYVVLDEADRMFDMGFEPQIMKIVNNIRPDRQTVLFSATFPRKVEALARKVLHKPIEIT 222
|
|
| DEADc_DDX23 |
cd17945 |
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and ... |
218-405 |
2.22e-58 |
|
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and PRP28 homolog) is involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Diseases associated with DDX23 include distal hereditary motor neuropathy, type II. DDX23 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350703 [Multi-domain] Cd Length: 220 Bit Score: 194.08 E-value: 2.22e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 218 LKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIIR--------AFSEDKTPSALILTPTRELAIQIER 289
Cdd:cd17945 5 IRKLGYKEPTPIQRQAIPIGLQNRDIIGIAETGSGKTAAFLIPLLVYisrlppldEETKDDGPYALILAPTRELAQQIEE 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 290 QAKELMSGLpRMKTVLLVGGLPLPPQLYRLRQHVKVIIATPGRLLDIIKQSSVSLSGIKIVVVDEADTMLKMGFQQQVLD 369
Cdd:cd17945 85 ETQKFAKPL-GIRVVSIVGGHSIEEQAFSLRNGCEILIATPGRLLDCLERRLLVLNQCTYVVLDEADRMIDMGFEPQVTK 163
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 568909597 370 VLEHTPGDC--------------------QTILVSATIPDSIEQLTDQLLHNPVRI 405
Cdd:cd17945 164 ILDAMPVSNkkpdteeaeklaasgkhryrQTMMFTATMPPAVEKIAKGYLRRPVVV 219
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
227-394 |
4.59e-55 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 183.60 E-value: 4.59e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 227 TPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIIRAFSEDKTPSALILTPTRELAIQIERQAKELMSGLpRMKTVLL 306
Cdd:pfam00270 1 TPIQAEAIPAILEGRDVLVQAPTGSGKTLAFLLPALEALDKLDNGPQALVLAPTRELAEQIYEELKKLGKGL-GLKVASL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 307 VGGLPLPPQLYRLRqHVKVIIATPGRLLDIIKQsSVSLSGIKIVVVDEADTMLKMGFQQQVLDVLEHTPGDCQTILVSAT 386
Cdd:pfam00270 80 LGGDSRKEQLEKLK-GPDILVGTPGRLLDLLQE-RKLLKNLKLLVLDEAHRLLDMGFGPDLEEILRRLPKKRQILLLSAT 157
|
....*...
gi 568909597 387 IPDSIEQL 394
Cdd:pfam00270 158 LPRNLEDL 165
|
|
| DEADc_DDX47 |
cd17954 |
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can ... |
205-405 |
6.03e-55 |
|
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can shuttle between the nucleus and the cytoplasm, and has an RNA-independent ATPase activity. DX47 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350712 [Multi-domain] Cd Length: 203 Bit Score: 184.44 E-value: 6.03e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 205 FEHCGFPETLNQNLKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPvIIRAFSEDKTP-SALILTPTREL 283
Cdd:cd17954 2 FKELGVCEELCEACEKLGWKKPTKIQEEAIPVALQGRDIIGLAETGSGKTAAFALP-ILQALLENPQRfFALVLAPTREL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 284 AIQIERQAKELMSGLPrMKTVLLVGGLPLPPQLYRLRQHVKVIIATPGRLLDIIKQSS-VSLSGIKIVVVDEADTMLKMG 362
Cdd:cd17954 81 AQQISEQFEALGSSIG-LKSAVLVGGMDMMAQAIALAKKPHVIVATPGRLVDHLENTKgFSLKSLKFLVMDEADRLLNMD 159
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 568909597 363 FQQQVLDVLEHTPGDCQTILVSATIPDSIEQLTDQLLHNPVRI 405
Cdd:cd17954 160 FEPEIDKILKVIPRERTTYLFSATMTTKVAKLQRASLKNPVKI 202
|
|
| DEADc_DDX42 |
cd17952 |
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor ... |
214-405 |
8.61e-53 |
|
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor 3B-Associated 125 kDa Protein, RHELP, or RNAHP) is an NTPase with a preference for ATP, the hydrolysis of which is enhanced by various RNA substrates. It acts as a non-processive RNA helicase with protein displacement and RNA annealing activities. DDX42 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350710 [Multi-domain] Cd Length: 197 Bit Score: 178.76 E-value: 8.61e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 214 LNQNLKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVII-----RAFSEDKTPSALILTPTRELAIQIE 288
Cdd:cd17952 1 LLNAIRKQEYEQPTPIQAQALPVALSGRDMIGIAKTGSGKTAAFIWPMLVhimdqRELEKGEGPIAVIVAPTRELAQQIY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 289 RQAKELmSGLPRMKTVLLVGGLPLPPQLYRLRQHVKVIIATPGRLLDIIKQSSVSLSGIKIVVVDEADTMLKMGFQQQVL 368
Cdd:cd17952 81 LEAKKF-GKAYNLRVVAVYGGGSKWEQAKALQEGAEIVVATPGRLIDMVKKKATNLQRVTYLVLDEADRMFDMGFEYQVR 159
|
170 180 190
....*....|....*....|....*....|....*..
gi 568909597 369 DVLEHTPGDCQTILVSATIPDSIEQLTDQLLHNPVRI 405
Cdd:cd17952 160 SIVGHVRPDRQTLLFSATFKKKIEQLARDILSDPIRV 196
|
|
| DEADc_DDX6 |
cd17940 |
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or ... |
205-405 |
6.22e-52 |
|
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or p54) participates in mRNA regulation mediated by miRNA-mediated silencing. It also plays a role in global and transcript-specific messenger RNA (mRNA) storage, translational repression, and decay. It is a member of the DEAD-box helicase family, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350698 [Multi-domain] Cd Length: 201 Bit Score: 176.33 E-value: 6.22e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 205 FEHCGFPETLNQNLKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIIRAFSEDKTPSALILTPTRELA 284
Cdd:cd17940 1 FEDYGLKRELLMGIFEKGFEKPSPIQEESIPIALSGRDILARAKNGTGKTGAYLIPILEKIDPKKDVIQALILVPTRELA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 285 IQIERQAKELMSGLpRMKTVLLVGGLPLPPQLYRLRQHVKVIIATPGRLLDIIKQSSVSLSGIKIVVVDEADTMLKMGFQ 364
Cdd:cd17940 81 LQTSQVCKELGKHM-GVKVMVTTGGTSLRDDIMRLYQTVHVLVGTPGRILDLAKKGVADLSHCKTLVLDEADKLLSQDFQ 159
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 568909597 365 QQVLDVLEHTPGDCQTILVSATIPDSIEQLTDQLLHNPVRI 405
Cdd:cd17940 160 PIIEKILNFLPKERQILLFSATFPLTVKNFMDRHMHNPYEI 200
|
|
| PRK11634 |
PRK11634 |
ATP-dependent RNA helicase DeaD; Provisional |
203-546 |
1.32e-51 |
|
ATP-dependent RNA helicase DeaD; Provisional
Pssm-ID: 236941 [Multi-domain] Cd Length: 629 Bit Score: 186.98 E-value: 1.32e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 203 IDFEHCGFPETLNQNLKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIIRAFSEDKTPSALILTPTRE 282
Cdd:PRK11634 6 TTFADLGLKAPILEALNDLGYEKPSPIQAECIPHLLNGRDVLGMAQTGSGKTAAFSLPLLHNLDPELKAPQILVLAPTRE 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 283 LAIQIERQAKELMSGLPRMKTVLLVGGLPLPPQLYRLRQHVKVIIATPGRLLDIIKQSSVSLSGIKIVVVDEADTMLKMG 362
Cdd:PRK11634 86 LAVQVAEAMTDFSKHMRGVNVVALYGGQRYDVQLRALRQGPQIVVGTPGRLLDHLKRGTLDLSKLSGLVLDEADEMLRMG 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 363 FQQQVLDVLEHTPGDCQTILVSATIPDSIEQLTDQLLHNP--VRIITGDKNLPcaSVRQIILWVEDPAKKKKLFEILNDQ 440
Cdd:PRK11634 166 FIEDVETIMAQIPEGHQTALFSATMPEAIRRITRRFMKEPqeVRIQSSVTTRP--DISQSYWTVWGMRKNEALVRFLEAE 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 441 KLfkPPVLVFVDCKLGADLLSEAVQKiTGLNSTSIHSEKSQVERR-----------DIL--------------------- 488
Cdd:PRK11634 244 DF--DAAIIFVRTKNATLEVAEALER-NGYNSAALNGDMNQALREqtlerlkdgrlDILiatdvaargldverislvvny 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568909597 489 -----------KVGRVGRLGQNGTAITFINNNSKRLFWDVAKRVKPTgsiLPPQLLNSPYLHEQKRKEQ 546
Cdd:PRK11634 321 dipmdsesyvhRIGRTGRAGRAGRALLFVENRERRLLRNIERTMKLT---IPEVELPNAELLGKRRLEK 386
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
218-413 |
2.99e-50 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 171.91 E-value: 2.99e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 218 LKKSGYEVPTPIQMQMIPVGLLG-RDILASADTGSGKTAAFLLPvIIRAFSEDKTPSALILTPTRELAIQIERQAKELMS 296
Cdd:smart00487 1 IEKFGFEPLRPYQKEAIEALLSGlRDVILAAPTGSGKTLAALLP-ALEALKRGKGGRVLVLVPTRELAEQWAEELKKLGP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 297 GLPRmKTVLLVGGLPLPPQLYRL-RQHVKVIIATPGRLLDIIKQSSVSLSGIKIVVVDEADTMLKMGFQQQVLDVLEHTP 375
Cdd:smart00487 80 SLGL-KVVGLYGGDSKREQLRKLeSGKTDILVTTPGRLLDLLENDKLSLSNVDLVILDEAHRLLDGGFGDQLEKLLKLLP 158
|
170 180 190
....*....|....*....|....*....|....*...
gi 568909597 376 GDCQTILVSATIPDSIEQLTDQLLHNPVRIITGDKNLP 413
Cdd:smart00487 159 KNVQLLLLSATPPEEIENLLELFLNDPVFIDVGFTPLE 196
|
|
| DEADc_MSS116 |
cd17964 |
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for ... |
218-394 |
5.19e-50 |
|
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for mitochondrial group I and II intron splicing, translational activation, and RNA end processing. Mss116 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350722 [Multi-domain] Cd Length: 211 Bit Score: 171.61 E-value: 5.19e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 218 LKKSGYEVPTPIQMQMIPVGL-LGRDILASADTGSGKTAAFLLPVIIRAFSEDKTP-----SALILTPTRELAIQIERQA 291
Cdd:cd17964 9 LTRMGFETMTPVQQKTLKPILsTGDDVLARAKTGTGKTLAFLLPAIQSLLNTKPAGrrsgvSALIISPTRELALQIAAEA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 292 KELMSGLPRMKTVLLVGGLPLPPQLYRL-RQHVKVIIATPGRLLDIIKQSSV--SLSGIKIVVVDEADTMLKMGFQQQVL 368
Cdd:cd17964 89 KKLLQGLRKLRVQSAVGGTSRRAELNRLrRGRPDILVATPGRLIDHLENPGVakAFTDLDYLVLDEADRLLDMGFRPDLE 168
|
170 180 190
....*....|....*....|....*....|
gi 568909597 369 DVLEHTP----GDCQTILVSATIPDSIEQL 394
Cdd:cd17964 169 QILRHLPeknaDPRQTLLFSATVPDEVQQI 198
|
|
| DEADc_DDX17 |
cd18050 |
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or ... |
168-408 |
2.35e-49 |
|
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or DEAD Box Protein P82) has a wide variety of functions including regulating the alternative splicing of exons exhibiting specific features such as the inclusion of AC-rich alternative exons in CD44 transcripts, playing a role in innate immunity, and promoting mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1 in an ATPase-dependent manner. DDX17 synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. DDX17 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350808 [Multi-domain] Cd Length: 271 Bit Score: 172.12 E-value: 2.35e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 168 YKEHPFIVTLKEDQIETLKQQLGISVQGQDVARPIIDFEHCGFPETLNQNLKKSGYEVPTPIQMQMIPVGLLGRDILASA 247
Cdd:cd18050 27 YVEHPEVARMTQYDVEELRRKKEITIRGVGCPKPVFAFHQANFPQYVMDVLLDQNFKEPTPIQCQGFPLALSGRDMVGIA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 248 DTGSGKTAAFLLPVIIRA-----FSEDKTPSALILTPTRELAIQIERQAKELMSGlPRMKTVLLVGGLPLPPQLYRLRQH 322
Cdd:cd18050 107 QTGSGKTLAYLLPAIVHInhqpyLERGDGPICLVLAPTRELAQQVQQVADDYGKS-SRLKSTCIYGGAPKGPQIRDLERG 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 323 VKVIIATPGRLLDIIKQSSVSLSGIKIVVVDEADTMLKMGFQQQVLDVLEHTPGDCQTILVSATIPDSIEQLTDQLLHNP 402
Cdd:cd18050 186 VEICIATPGRLIDFLEAGKTNLRRCTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLRDY 265
|
....*.
gi 568909597 403 VRIITG 408
Cdd:cd18050 266 VQINIG 271
|
|
| DEADc_DDX41 |
cd17951 |
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts ... |
218-405 |
2.88e-49 |
|
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts with several spliceosomal proteins and may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response. Diseases associated with DDX41 include "myeloproliferative/lymphoproliferative neoplasms, familial" and "Ddx41-related susceptibility to familial myeloproliferative/lymphoproliferative neoplasms". DDX41 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350709 [Multi-domain] Cd Length: 206 Bit Score: 169.44 E-value: 2.88e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 218 LKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIIRAFSEDKT--------PSALILTPTRELAIQ--- 286
Cdd:cd17951 5 LKKKGIKKPTPIQMQGLPTILSGRDMIGIAFTGSGKTLVFTLPLIMFALEQEKKlpfikgegPYGLIVCPSRELARQthe 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 287 -IERQAKELM-SGLPRMKTVLLVGGLPLPPQLYRLRQHVKVIIATPGRLLDIIKQSSVSLSGIKIVVVDEADTMLKMGFQ 364
Cdd:cd17951 85 vIEYYCKALQeGGYPQLRCLLCIGGMSVKEQLEVIRKGVHIVVATPGRLMDMLNKKKINLDICRYLCLDEADRMIDMGFE 164
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 568909597 365 QQVLDVLEHTPGDCQTILVSATIPDSIEQLTDQLLHNPVRI 405
Cdd:cd17951 165 EDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVKPVTV 205
|
|
| DEADc_DDX5_DDX17 |
cd17966 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are ... |
218-405 |
4.25e-49 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350724 [Multi-domain] Cd Length: 197 Bit Score: 168.70 E-value: 4.25e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 218 LKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIIRA-----FSEDKTPSALILTPTRELAIQIERQAK 292
Cdd:cd17966 5 LKRQGFTEPTAIQAQGWPMALSGRDMVGIAQTGSGKTLAFLLPAIVHInaqppLERGDGPIVLVLAPTRELAQQIQQEAN 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 293 ELmSGLPRMKTVLLVGGLPLPPQLYRLRQHVKVIIATPGRLLDIIKQSSVSLSGIKIVVVDEADTMLKMGFQQQVLDVLE 372
Cdd:cd17966 85 KF-GGSSRLRNTCVYGGAPKGPQIRDLRRGVEICIATPGRLIDFLDQGKTNLRRVTYLVLDEADRMLDMGFEPQIRKIVD 163
|
170 180 190
....*....|....*....|....*....|...
gi 568909597 373 HTPGDCQTILVSATIPDSIEQLTDQLLHNPVRI 405
Cdd:cd17966 164 QIRPDRQTLMWSATWPKEVRRLAEDFLKDYIQV 196
|
|
| DEADc_DDX5 |
cd18049 |
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, ... |
181-408 |
4.25e-49 |
|
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, G17P1, or HUMP68) is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. It synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. Dysregulation of this gene may play a role in cancer development. DDX5 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350807 [Multi-domain] Cd Length: 234 Bit Score: 170.19 E-value: 4.25e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 181 QIETLKQQLGISVQGQDVARPIIDFEHCGFPETLNQNLKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLP 260
Cdd:cd18049 2 EVEQYRRSKEITVRGHNCPKPVLNFYEANFPANVMDVIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLP 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 261 VII----RAFSE-DKTPSALILTPTRELAIQIERQAKELMSGLpRMKTVLLVGGLPLPPQLYRLRQHVKVIIATPGRLLD 335
Cdd:cd18049 82 AIVhinhQPFLErGDGPICLVLAPTRELAQQVQQVAAEYGRAC-RLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLID 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568909597 336 IIKQSSVSLSGIKIVVVDEADTMLKMGFQQQVLDVLEHTPGDCQTILVSATIPDSIEQLTDQLLHNPVRIITG 408
Cdd:cd18049 161 FLEAGKTNLRRCTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLKDYIHINIG 233
|
|
| DEADc_DDX49 |
cd17955 |
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the ... |
205-403 |
9.77e-49 |
|
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350713 [Multi-domain] Cd Length: 204 Bit Score: 168.17 E-value: 9.77e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 205 FEHCGFPETLNQNLKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIIRaFSEDktPS---ALILTPTR 281
Cdd:cd17955 1 FEDLGLSSWLVKQCASLGIKEPTPIQKLCIPEILAGRDVIGGAKTGSGKTAAFALPILQR-LSED--PYgifALVLTPTR 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 282 ELAIQIERQAKELMSGLpRMKTVLLVGGLPLPPQLYRLRQHVKVIIATPGRLLDIIKQSSV---SLSGIKIVVVDEADTM 358
Cdd:cd17955 78 ELAYQIAEQFRALGAPL-GLRCCVIVGGMDMVKQALELSKRPHIVVATPGRLADHLRSSDDttkVLSRVKFLVLDEADRL 156
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 568909597 359 LKMGFQQQVLDVLEHTPGDCQTILVSATIPDSIEQLTDQLLHNPV 403
Cdd:cd17955 157 LTGSFEDDLATILSALPPKRQTLLFSATLTDALKALKELFGNKPF 201
|
|
| PRK11192 |
PRK11192 |
ATP-dependent RNA helicase SrmB; Provisional |
204-506 |
1.90e-48 |
|
ATP-dependent RNA helicase SrmB; Provisional
Pssm-ID: 236877 [Multi-domain] Cd Length: 434 Bit Score: 174.36 E-value: 1.90e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 204 DFEHCGFPETLNQNLKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVI--IRAFSEDKT--PSALILTP 279
Cdd:PRK11192 2 TFSELELDESLLEALQDKGYTRPTAIQAEAIPPALDGRDVLGSAPTGTGKTAAFLLPALqhLLDFPRRKSgpPRILILTP 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 280 TRELAIQIERQAKELMSGLpRMKTVLLVGGLPLPPQLYRLRQHVKVIIATPGRLLDIIKQSSVSLSGIKIVVVDEADTML 359
Cdd:PRK11192 82 TRELAMQVADQARELAKHT-HLDIATITGGVAYMNHAEVFSENQDIVVATPGRLLQYIKEENFDCRAVETLILDEADRML 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 360 KMGFQQQVldvlEHTPGDC----QTILVSATIP-DSIEQLTDQLLHNPVRIitgDKNLPCASVRQIILWV----EDPAKK 430
Cdd:PRK11192 161 DMGFAQDI----ETIAAETrwrkQTLLFSATLEgDAVQDFAERLLNDPVEV---EAEPSRRERKKIHQWYyradDLEHKT 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 431 KKLFEILNDQKLFKppVLVFVDCKLGADLLSEAVQKiTGLNSTSIHSEKSQVERRDILK--------------------- 489
Cdd:PRK11192 234 ALLCHLLKQPEVTR--SIVFVRTRERVHELAGWLRK-AGINCCYLEGEMVQAKRNEAIKrltdgrvnvlvatdvaargid 310
|
330 340 350
....*....|....*....|....*....|....*....
gi 568909597 490 ----------------------VGRVGRLGQNGTAITFI 506
Cdd:PRK11192 311 iddvshvinfdmprsadtylhrIGRTGRAGRKGTAISLV 349
|
|
| DEADc_DDX3 |
cd18051 |
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD ... |
195-401 |
2.16e-48 |
|
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD box, X isoform, or DDX14) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. Diseases associated with DDX3 include mental retardation, X-linked 102 and agenesis of the corpus callosum, with facial anomalies and robin sequence. DDX3 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350809 [Multi-domain] Cd Length: 249 Bit Score: 168.68 E-value: 2.16e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 195 GQDVARPIIDFEHCGFPETLNQNLKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIIRAFSE------ 268
Cdd:cd18051 13 GENCPPHIETFSDLDLGEIIRNNIELARYTKPTPVQKHAIPIIKSKRDLMACAQTGSGKTAAFLLPILSQIYEQgpgesl 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 269 ----------DKTPSALILTPTRELAIQIERQAKELmSGLPRMKTVLLVGGLPLPPQLYRLRQHVKVIIATPGRLLDIIK 338
Cdd:cd18051 93 psesgyygrrKQYPLALVLAPTRELASQIYDEARKF-AYRSRVRPCVVYGGADIGQQMRDLERGCHLLVATPGRLVDMLE 171
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568909597 339 QSSVSLSGIKIVVVDEADTMLKMGFQQQVLDVLEH----TPGDCQTILVSATIPDSIEQLTDQLLHN 401
Cdd:cd18051 172 RGKIGLDYCKYLVLDEADRMLDMGFEPQIRRIVEQdtmpPTGERQTLMFSATFPKEIQMLARDFLDN 238
|
|
| DEADc_DDX56 |
cd17961 |
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of ... |
214-403 |
2.83e-48 |
|
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of infectious West Nile virus particles. New research suggests that DDX56 relocalizes to the site of virus assembly during WNV infection and that its interaction with WNV capsid in the cytoplasm may occur transiently during virion morphogenesis. DDX56 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350719 [Multi-domain] Cd Length: 206 Bit Score: 166.99 E-value: 2.83e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 214 LNQNLKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIIRAFSEDKT------PSALILTPTRELAIQI 287
Cdd:cd17961 5 LLKAIAKLGWEKPTLIQSKAIPLALEGKDILARARTGSGKTAAYALPIIQKILKAKAEsgeeqgTRALILVPTRELAQQV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 288 ERQAKELMSGL-PRMKTVLLVGGLPLPPQLYRLRQHVKVIIATPGRLLDIIKQ-SSVSLSGIKIVVVDEADTMLKMGFQQ 365
Cdd:cd17961 85 SKVLEQLTAYCrKDVRVVNLSASSSDSVQRALLAEKPDIVVSTPARLLSHLESgSLLLLSTLKYLVIDEADLVLSYGYEE 164
|
170 180 190
....*....|....*....|....*....|....*...
gi 568909597 366 QVLDVLEHTPGDCQTILVSATIPDSIEQLTDQLLHNPV 403
Cdd:cd17961 165 DLKSLLSYLPKNYQTFLMSATLSEDVEALKKLVLHNPA 202
|
|
| DEADc_DDX10 |
cd17941 |
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin ... |
218-405 |
1.09e-47 |
|
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. Diseases associated with DDX10 (also known as DDX10-NUP98 Fusion Protein Type 2) include myelodysplastic syndrome and leukemia, acute myeloid. DDX10 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350699 [Multi-domain] Cd Length: 198 Bit Score: 165.16 E-value: 1.09e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 218 LKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIIRAFSEDKTPS----ALILTPTRELAIQIERQAKE 293
Cdd:cd17941 5 LKEAGFIKMTEIQRDSIPHALQGRDILGAAKTGSGKTLAFLVPLLEKLYRERWTPEdglgALIISPTRELAMQIFEVLRK 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 294 LMSGlPRMKTVLLVGGLPLPPQLYRLRQhVKVIIATPGRLLDIIKQS-SVSLSGIKIVVVDEADTMLKMGFQQQVLDVLE 372
Cdd:cd17941 85 VGKY-HSFSAGLIIGGKDVKEEKERINR-MNILVCTPGRLLQHMDETpGFDTSNLQMLVLDEADRILDMGFKETLDAIVE 162
|
170 180 190
....*....|....*....|....*....|...
gi 568909597 373 HTPGDCQTILVSATIPDSIEQLTDQLLHNPVRI 405
Cdd:cd17941 163 NLPKSRQTLLFSATQTKSVKDLARLSLKNPEYI 195
|
|
| DEADc_DDX43_DDX53 |
cd17958 |
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis ... |
216-405 |
1.69e-47 |
|
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis antigen 13 or helical antigen) displays tumor-specific expression. Diseases associated with DDX43 include rheumatoid lung disease. DDX53 is also called cancer/testis antigen 26 or DEAD-Box Protein CAGE. Both DDX46 and DDX53 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350716 [Multi-domain] Cd Length: 197 Bit Score: 164.56 E-value: 1.69e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 216 QNLKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIIRAFSE------DKTPSALILTPTRELAIQIER 289
Cdd:cd17958 3 KEIKKQGFEKPSPIQSQAWPIILQGIDLIGVAQTGTGKTLAYLLPGFIHLDLQpipreqRNGPGVLVLTPTRELALQIEA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 290 Q-AKELMSGlprMKTVLLVGGLPLPPQLYRLRQHVKVIIATPGRLLDIIKQSSVSLSGIKIVVVDEADTMLKMGFQQQVL 368
Cdd:cd17958 83 EcSKYSYKG---LKSVCVYGGGNRNEQIEDLSKGVDIIIATPGRLNDLQMNNVINLKSITYLVLDEADRMLDMGFEPQIR 159
|
170 180 190
....*....|....*....|....*....|....*..
gi 568909597 369 DVLEHTPGDCQTILVSATIPDSIEQLTDQLLHNPVRI 405
Cdd:cd17958 160 KILLDIRPDRQTIMTSATWPDGVRRLAQSYLKDPMIV 196
|
|
| DEADc_EIF4A |
cd17939 |
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation ... |
213-406 |
2.76e-47 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation factor-4A (eIF4A) family consists of 3 proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA. EIF4A proteins are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350697 [Multi-domain] Cd Length: 199 Bit Score: 164.03 E-value: 2.76e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 213 TLNQNLKKS----GYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIIRAFSEDKTPSALILTPTRELAIQIE 288
Cdd:cd17939 3 GLSEDLLRGiyayGFEKPSAIQQRAIVPIIKGRDVIAQAQSGTGKTATFSIGALQRIDTTVRETQALVLAPTRELAQQIQ 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 289 RQAKELMSGLpRMKTVLLVGGLPLPPQLYRLRQHVKVIIATPGRLLDIIKQSSVSLSGIKIVVVDEADTMLKMGFQQQVL 368
Cdd:cd17939 83 KVVKALGDYM-GVKVHACIGGTSVREDRRKLQYGPHIVVGTPGRVFDMLQRRSLRTDKIKMFVLDEADEMLSRGFKDQIY 161
|
170 180 190
....*....|....*....|....*....|....*...
gi 568909597 369 DVLEHTPGDCQTILVSATIPDSIEQLTDQLLHNPVRII 406
Cdd:cd17939 162 DIFQFLPPETQVVLFSATMPHEVLEVTKKFMRDPVRIL 199
|
|
| DEADc_DDX1 |
cd17938 |
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ... |
205-403 |
7.70e-44 |
|
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. It possesses 5' single-stranded RNA overhang nuclease activity as well as ATPase activity on various RNA, but not DNA polynucleotides. DDX1 may play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. It may also be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. DDX1 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350696 [Multi-domain] Cd Length: 204 Bit Score: 154.79 E-value: 7.70e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 205 FEHCGFPETLNQNLKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIirafsedKTPSALILTPTRELA 284
Cdd:cd17938 1 FEELGVMPELIKAVEELDWLLPTDIQAEAIPLILGGGDVLMAAETGSGKTGAFCLPVL-------QIVVALILEPSRELA 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 285 IQ----IERQAKELMSglPRMKTVLLVGGLPLPPQLYRLRQHVKVIIATPGRLLDIIKQSSVSLSGIKIVVVDEADTMLK 360
Cdd:cd17938 74 EQtyncIENFKKYLDN--PKLRVALLIGGVKAREQLKRLESGVDIVVGTPGRLEDLIKTGKLDLSSVRFFVLDEADRLLS 151
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 568909597 361 MGFQQQVLDVLE----HTPGD--CQTILVSATI-PDSIEQLTDQLLHNPV 403
Cdd:cd17938 152 QGNLETINRIYNripkITSDGkrLQVIVCSATLhSFEVKKLADKIMHFPT 201
|
|
| DEADc_DDX20 |
cd17943 |
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, ... |
218-405 |
5.20e-43 |
|
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, Component Of Gems 3, Gemin-3, and SMN-Interacting Protein) interacts directly with SMN (survival of motor neurons), the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on ribonucleoproteins. Diseases associated with DDX20 include spinal muscular atrophy and muscular atrophy. DDX20 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350701 [Multi-domain] Cd Length: 192 Bit Score: 152.42 E-value: 5.20e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 218 LKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIIRAFSEDKTPSALILTPTRELAIQIERQAKELMSG 297
Cdd:cd17943 5 LKAAGFQRPSPIQLAAIPLGLAGHDLIVQAKSGTGKTLVFVVIALESLDLERRHPQVLILAPTREIAVQIHDVFKKIGKK 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 298 LPRMKTVLLVGGLPLPPQLYRLRQhVKVIIATPGRLLDIIKQSSVSLSGIKIVVVDEADTMLKMGFQQQVLDVLEHTPGD 377
Cdd:cd17943 85 LEGLKCEVFIGGTPVKEDKKKLKG-CHIAVGTPGRIKQLIELGALNVSHVRLFVLDEADKLMEGSFQKDVNWIFSSLPKN 163
|
170 180
....*....|....*....|....*...
gi 568909597 378 CQTILVSATIPDSIEQLTDQLLHNPVRI 405
Cdd:cd17943 164 KQVIAFSATYPKNLDNLLARYMRKPVLV 191
|
|
| DEADc_DDX55 |
cd17960 |
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, ... |
218-405 |
1.03e-42 |
|
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350718 [Multi-domain] Cd Length: 202 Bit Score: 151.96 E-value: 1.03e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 218 LKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPV--IIRAFSEDKTPS---ALILTPTRELAIQIERQAK 292
Cdd:cd17960 5 VAELGFTSMTPVQAATIPLFLSNKDVVVEAVTGSGKTLAFLIPVleILLKRKANLKKGqvgALIISPTRELATQIYEVLQ 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 293 ELMS-GLPRMKTVLLVGGLPLPPQLYRLRQH-VKVIIATPGRLLDII--KQSSVSLSGIKIVVVDEADTMLKMGFQQQVL 368
Cdd:cd17960 85 SFLEhHLPKLKCQLLIGGTNVEEDVKKFKRNgPNILVGTPGRLEELLsrKADKVKVKSLEVLVLDEADRLLDLGFEADLN 164
|
170 180 190
....*....|....*....|....*....|....*..
gi 568909597 369 DVLEHTPGDCQTILVSATIPDSIEQLTDQLLHNPVRI 405
Cdd:cd17960 165 RILSKLPKQRRTGLFSATQTDAVEELIKAGLRNPVRV 201
|
|
| PRK04537 |
PRK04537 |
ATP-dependent RNA helicase RhlB; Provisional |
200-505 |
2.83e-42 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235307 [Multi-domain] Cd Length: 572 Bit Score: 160.12 E-value: 2.83e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 200 RPIIDFEHCGFP--ETLNQNLKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIIRAFS---------E 268
Cdd:PRK04537 4 KPLTDLTFSSFDlhPALLAGLESAGFTRCTPIQALTLPVALPGGDVAGQAQTGTGKTLAFLVAVMNRLLSrpaladrkpE 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 269 DktPSALILTPTRELAIQIERQAKELMSGLPrMKTVLLVGGLPLPPQLYRLRQHVKVIIATPGRLLDIIKQSS-VSLSGI 347
Cdd:PRK04537 84 D--PRALILAPTRELAIQIHKDAVKFGADLG-LRFALVYGGVDYDKQRELLQQGVDVIIATPGRLIDYVKQHKvVSLHAC 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 348 KIVVVDEADTMLKMGFQQQVLDVLEHTPGDC--QTILVSATIPDSIEQLTDQLLHNPVRIITGDKNLPCASVRQIILWVE 425
Cdd:PRK04537 161 EICVLDEADRMFDLGFIKDIRFLLRRMPERGtrQTLLFSATLSHRVLELAYEHMNEPEKLVVETETITAARVRQRIYFPA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 426 DPAKKKKLFEILNDQKLFKppVLVFVDCKLGADLLSEAVQKiTGLNSTSIHSEKSQVERRDIL----------------- 488
Cdd:PRK04537 241 DEEKQTLLLGLLSRSEGAR--TMVFVNTKAFVERVARTLER-HGYRVGVLSGDVPQKKRESLLnrfqkgqleilvatdva 317
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 568909597 489 --------------------------KVGRVGRLGQNGTAITF 505
Cdd:PRK04537 318 arglhidgvkyvynydlpfdaedyvhRIGRTARLGEEGDAISF 360
|
|
| DEADc_DDX31 |
cd17949 |
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) ... |
214-405 |
3.88e-42 |
|
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1. DDX31 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350707 [Multi-domain] Cd Length: 214 Bit Score: 150.81 E-value: 3.88e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 214 LNQNLK-KSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIIRAFSEDKT------PSALILTPTRELAIQ 286
Cdd:cd17949 1 LVSHLKsKMGIEKPTAIQKLAIPVLLQGRDVLVRSQTGSGKTLAYLLPIIQRLLSLEPRvdrsdgTLALVLVPTRELALQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 287 IERQAKELMSGLPRMKTVLLVGGLPLPPQLYRLRQHVKVIIATPGRLLDIIKQ-SSVSLSGIKIVVVDEADTMLKMGFQQ 365
Cdd:cd17949 81 IYEVLEKLLKPFHWIVPGYLIGGEKRKSEKARLRKGVNILIATPGRLLDHLKNtQSFDVSNLRWLVLDEADRLLDMGFEK 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 568909597 366 QVLDVLEH-------------TPGDCQTILVSATIPDSIEQLTDQLLHNPVRI 405
Cdd:cd17949 161 DITKILELlddkrskaggeksKPSRRQTVLVSATLTDGVKRLAGLSLKDPVYI 213
|
|
| PRK01297 |
PRK01297 |
ATP-dependent RNA helicase RhlB; Provisional |
222-496 |
4.95e-41 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 234938 [Multi-domain] Cd Length: 475 Bit Score: 154.69 E-value: 4.95e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 222 GYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVII----------RAFSEdktPSALILTPTRELAIQIERQA 291
Cdd:PRK01297 106 GFPYCTPIQAQVLGYTLAGHDAIGRAQTGTGKTAAFLISIINqllqtpppkeRYMGE---PRALIIAPTRELVVQIAKDA 182
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 292 KELM--SGLPRMKtvlLVGGLPLPPQLYRLR-QHVKVIIATPGRLLDIIKQSSVSLSGIKIVVVDEADTMLKMGFQQQVL 368
Cdd:PRK01297 183 AALTkyTGLNVMT---FVGGMDFDKQLKQLEaRFCDILVATPGRLLDFNQRGEVHLDMVEVMVLDEADRMLDMGFIPQVR 259
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 369 DVLEHTP--GDCQTILVSATIPDSIEQLTDQLLHNPVRIITGDKNLPCASVRQIILWVEDPAKKKKLFEILNDQKLFKpp 446
Cdd:PRK01297 260 QIIRQTPrkEERQTLLFSATFTDDVMNLAKQWTTDPAIVEIEPENVASDTVEQHVYAVAGSDKYKLLYNLVTQNPWER-- 337
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 568909597 447 VLVFVDCKLGADLLSEAVQKiTGLNSTSIHSEKSQVERRDILKVGRVGRL 496
Cdd:PRK01297 338 VMVFANRKDEVRRIEERLVK-DGINAAQLSGDVPQHKRIKTLEGFREGKI 386
|
|
| DEADc_DDX24 |
cd17946 |
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box ... |
216-387 |
1.24e-40 |
|
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24. DDX24 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350704 [Multi-domain] Cd Length: 235 Bit Score: 147.39 E-value: 1.24e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 216 QNLKKSGYEVPTPIQMQMIPVGLL-GRDILASADTGSGKTAAFLLPVIIR---------AFSEDKTPSALILTPTRELAI 285
Cdd:cd17946 3 RALADLGFSEPTPIQALALPAAIRdGKDVIGAAETGSGKTLAFGIPILERllsqkssngVGGKQKPLRALILTPTRELAV 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 286 QIERQAKELMSGlPRMKTVLLVGGLPLPPQLYRLRQHVKVIIATPGRLLDIIKQSS---VSLSGIKIVVVDEADTMLKMG 362
Cdd:cd17946 83 QVKDHLKAIAKY-TNIKIASIVGGLAVQKQERLLKKRPEIVVATPGRLWELIQEGNehlANLKSLRFLVLDEADRMLEKG 161
|
170 180 190
....*....|....*....|....*....|..
gi 568909597 363 -FQ--QQVLDVL-EHTPGDC---QTILVSATI 387
Cdd:cd17946 162 hFAelEKILELLnKDRAGKKrkrQTFVFSATL 193
|
|
| DEADc_EIF4AII_EIF4AI_DDX2 |
cd18046 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation ... |
222-406 |
4.79e-39 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation factor 4A-I (DDX2A) and eukaryotic initiation factor 4A-II (DDX2B) are involved in cap recognition and are required for mRNA binding to ribosome. They are DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350804 [Multi-domain] Cd Length: 201 Bit Score: 141.81 E-value: 4.79e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 222 GYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIIRAFSEDKTPSALILTPTRELAIQIERQAKELMSGLpRM 301
Cdd:cd18046 18 GFEKPSAIQQRAIMPCIKGYDVIAQAQSGTGKTATFSISILQQIDTSLKATQALVLAPTRELAQQIQKVVMALGDYM-GI 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 302 KTVLLVGGLPLPPQLYRLRQHVKVIIATPGRLLDIIKQSSVSLSGIKIVVVDEADTMLKMGFQQQVLDVLEHTPGDCQTI 381
Cdd:cd18046 97 KCHACIGGTSVRDDAQKLQAGPHIVVGTPGRVFDMINRRYLRTDYIKMFVLDEADEMLSRGFKDQIYDIFQKLPPDTQVV 176
|
170 180
....*....|....*....|....*
gi 568909597 382 LVSATIPDSIEQLTDQLLHNPVRII 406
Cdd:cd18046 177 LLSATMPNDVLEVTTKFMRDPIRIL 201
|
|
| DEADc_EIF4AIII_DDX48 |
cd18045 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor ... |
205-406 |
1.93e-38 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor 4A-III (EIF4AIII, also known as DDX48) is part of the exon junction complex (EJC) that plays a major role in posttranscriptional regulation of mRNA. EJC consists of four proteins (eIF4AIII, Barentsz [Btz], Mago, and Y14), mRNA, and ATP. DDX48 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350803 [Multi-domain] Cd Length: 201 Bit Score: 140.30 E-value: 1.93e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 205 FEHCGFPETLNQNLKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIIRAFSEDKTPSALILTPTRELA 284
Cdd:cd18045 1 FETMGLREDLLRGIYAYGFEKPSAIQQRAIKPIIKGRDVIAQSQSGTGKTATFSISVLQCLDIQVRETQALILSPTRELA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 285 IQIERQAKELMSGLpRMKTVLLVGGLPLPPQLYRLRQHVKVIIATPGRLLDIIKQSSVSLSGIKIVVVDEADTMLKMGFQ 364
Cdd:cd18045 81 VQIQKVLLALGDYM-NVQCHACIGGTSVGDDIRKLDYGQHIVSGTPGRVFDMIRRRSLRTRHIKMLVLDEADEMLNKGFK 159
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 568909597 365 QQVLDVLEHTPGDCQTILVSATIPDSIEQLTDQLLHNPVRII 406
Cdd:cd18045 160 EQIYDVYRYLPPATQVVLVSATLPQDILEMTNKFMTDPIRIL 201
|
|
| PTZ00424 |
PTZ00424 |
helicase 45; Provisional |
205-494 |
1.04e-37 |
|
helicase 45; Provisional
Pssm-ID: 185609 [Multi-domain] Cd Length: 401 Bit Score: 143.81 E-value: 1.04e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 205 FEHCGFPETLNQNLKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIIRAFSEDKTPSALILTPTRELA 284
Cdd:PTZ00424 30 FDALKLNEDLLRGIYSYGFEKPSAIQQRGIKPILDGYDTIGQAQSGTGKTATFVIAALQLIDYDLNACQALILAPTRELA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 285 IQIERQAKELMSGLpRMKTVLLVGGLPLPPQLYRLRQHVKVIIATPGRLLDIIKQSSVSLSGIKIVVVDEADTMLKMGFQ 364
Cdd:PTZ00424 110 QQIQKVVLALGDYL-KVRCHACVGGTVVRDDINKLKAGVHMVVGTPGRVYDMIDKRHLRVDDLKLFILDEADEMLSRGFK 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 365 QQVLDVLEHTPGDCQTILVSATIPDSIEQLTDQLLHNPVRIITGDKNLPCASVRQIILWVEdpaKKKKLFEILND--QKL 442
Cdd:PTZ00424 189 GQIYDVFKKLPPDVQVALFSATMPNEILELTTKFMRDPKRILVKKDELTLEGIRQFYVAVE---KEEWKFDTLCDlyETL 265
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 568909597 443 FKPPVLVFVDCKLGADLLSEAVQKiTGLNSTSIHSEKSQVERRDILKVGRVG 494
Cdd:PTZ00424 266 TITQAIIYCNTRRKVDYLTKKMHE-RDFTVSCMHGDMDQKDRDLIMREFRSG 316
|
|
| DEADc_DDX18 |
cd17942 |
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein ... |
218-394 |
5.49e-37 |
|
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein and is activated by Myc protein. DDX18 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350700 [Multi-domain] Cd Length: 198 Bit Score: 135.95 E-value: 5.49e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 218 LKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIIRAFSEDKTP----SALILTPTRELAIQIERQAKE 293
Cdd:cd17942 5 IEEMGFTKMTEIQAKSIPPLLEGRDVLGAAKTGSGKTLAFLIPAIELLYKLKFKPrngtGVIIISPTRELALQIYGVAKE 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 294 LMSGlpRMKTVLLV-GGLPLPPQLYRLRQHVKVIIATPGRLLDIIKQSSVSL-SGIKIVVVDEADTMLKMGFQQQVLDVL 371
Cdd:cd17942 85 LLKY--HSQTFGIViGGANRKAEAEKLGKGVNILVATPGRLLDHLQNTKGFLyKNLQCLIIDEADRILEIGFEEEMRQII 162
|
170 180
....*....|....*....|...
gi 568909597 372 EHTPGDCQTILVSATIPDSIEQL 394
Cdd:cd17942 163 KLLPKRRQTMLFSATQTRKVEDL 185
|
|
| DEADc_DDX39 |
cd17950 |
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and ... |
211-405 |
2.38e-34 |
|
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and is required for the export of mRNA out of the nucleus. DDX39B is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. Diseases associated with DDX39A (also called UAP56-Related Helicase, 49 kDa) include gastrointestinal stromal tumor and inflammatory bowel disease 6, while diseases associated with DDX39B (also called 56 kDa U2AF65-Associated Protein) include Plasmodium vivax malaria. DDX39 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350708 [Multi-domain] Cd Length: 208 Bit Score: 129.00 E-value: 2.38e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 211 PETLNQnLKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIIRAFSEDKTPSALILTPTRELAIQIERQ 290
Cdd:cd17950 11 PELLRA-IVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLSTLQQLEPVDGQVSVLVICHTRELAFQISNE 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 291 AKELMSGLPRMKTVLLVGGLPLPPQLYRLR-QHVKVIIATPGRLLDIIKQSSVSLSGIKIVVVDEADTMLK-MGFQQQVL 368
Cdd:cd17950 90 YERFSKYMPNVKTAVFFGGVPIKKDIEVLKnKCPHIVVGTPGRILALVREKKLKLSHVKHFVLDECDKMLEqLDMRRDVQ 169
|
170 180 190
....*....|....*....|....*....|....*..
gi 568909597 369 DVLEHTPGDCQTILVSATIPDSIEQLTDQLLHNPVRI 405
Cdd:cd17950 170 EIFRATPHDKQVMMFSATLSKEIRPVCKKFMQDPLEI 206
|
|
| DEADc_DDX19_DDX25 |
cd17963 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called ... |
211-405 |
1.38e-33 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called DEAD box RNA helicase DEAD5) and DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH)) are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350721 [Multi-domain] Cd Length: 196 Bit Score: 126.54 E-value: 1.38e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 211 PETLNQNLKKSGYEVPTPIQMQMIPVgLLG---RDILASADTGSGKTAAFLLPVIIRAFSEDKTPSALILTPTRELAIQI 287
Cdd:cd17963 2 KPELLKGLYAMGFNKPSKIQETALPL-ILSdppENLIAQSQSGTGKTAAFVLAMLSRVDPTLKSPQALCLAPTRELARQI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 288 ERQAKELMSgLPRMKTVLLVGGLPLPPQlYRLRQHvkVIIATPGRLLDIIKQSSVSLSGIKIVVVDEADTMLKM-GFQQQ 366
Cdd:cd17963 81 GEVVEKMGK-FTGVKVALAVPGNDVPRG-KKITAQ--IVIGTPGTVLDWLKKRQLDLKKIKILVLDEADVMLDTqGHGDQ 156
|
170 180 190
....*....|....*....|....*....|....*....
gi 568909597 367 VLDVLEHTPGDCQTILVSATIPDSIEQLTDQLLHNPVRI 405
Cdd:cd17963 157 SIRIKRMLPRNCQILLFSATFPDSVRKFAEKIAPNANTI 195
|
|
| DEADc_DDX28 |
cd17948 |
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box ... |
214-400 |
1.86e-33 |
|
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box polypeptide 28) plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. DDX28 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350706 [Multi-domain] Cd Length: 231 Bit Score: 127.48 E-value: 1.86e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 214 LNQNLKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIIRAFsEDK--------TPSALILTPTRELAI 285
Cdd:cd17948 1 LVEILQRQGITKPTTVQKQGIPSILRGRNTLCAAETGSGKTLTYLLPIIQRLL-RYKllaegpfnAPRGLVITPSRELAE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 286 QIERQAKELMSGLPrMKTVLLVGGLPLPPQLYRLRQHVKVIIATPGRLLDIIKQSSVSLSGIKIVVVDEADTMLKMGFQQ 365
Cdd:cd17948 80 QIGSVAQSLTEGLG-LKVKVITGGRTKRQIRNPHFEEVDILVATPGALSKLLTSRIYSLEQLRHLVLDEADTLLDDSFNE 158
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568909597 366 QVLDVLEHTP-------------GDCQTILVSATIP-------------DSIEQLTDQLLH 400
Cdd:cd17948 159 KLSHFLRRFPlasrrsentdgldPGTQLVLVSATMPsgvgevlskvidvDSIETVTSDKLH 219
|
|
| PRK04837 |
PRK04837 |
ATP-dependent RNA helicase RhlB; Provisional |
216-405 |
2.99e-33 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235314 [Multi-domain] Cd Length: 423 Bit Score: 131.63 E-value: 2.99e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 216 QNLKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFL-------LPVIIRAFSEDKTPSALILTPTRELAIQIE 288
Cdd:PRK04837 21 EALEKKGFHNCTPIQALALPLTLAGRDVAGQAQTGTGKTMAFLtatfhylLSHPAPEDRKVNQPRALIMAPTRELAVQIH 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 289 RQAKEL--MSGLprmKTVLLVGGLPLPPQLYRLRQHVKVIIATPGRLLDIIKQSSVSLSGIKIVVVDEADTMLKMGFQQQ 366
Cdd:PRK04837 101 ADAEPLaqATGL---KLGLAYGGDGYDKQLKVLESGVDILIGTTGRLIDYAKQNHINLGAIQVVVLDEADRMFDLGFIKD 177
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 568909597 367 VLDVLEHTPGDCQ--TILVSATIPDSIEQLTDQLLHNPVRI 405
Cdd:PRK04837 178 IRWLFRRMPPANQrlNMLFSATLSYRVRELAFEHMNNPEYV 218
|
|
| DEADc_DDX51 |
cd17956 |
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by ... |
214-402 |
4.29e-32 |
|
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by regulating multiple signalling pathways. Mammalian DEAD box protein Ddx51 acts in 3' end maturation of 28S rRNA by promoting the release of U8 snoRNA.It is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350714 [Multi-domain] Cd Length: 231 Bit Score: 123.51 E-value: 4.29e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 214 LNQNLKKSGYEVPTPIQMQMIP---------VGLLGRDILASADTGSGKTAAFLLPvIIRAFSEDKTPS--ALILTPTRE 282
Cdd:cd17956 1 LLKNLQNNGITSAFPVQAAVIPwllpsskstPPYRPGDLCVSAPTGSGKTLAYVLP-IVQALSKRVVPRlrALIVVPTKE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 283 LAIQIERQAKELMSGLPrMKTVLLVGG------LPLPPQLYRLRQHVKV--IIATPGRLLDIIKQ-SSVSLSGIKIVVVD 353
Cdd:cd17956 80 LVQQVYKVFESLCKGTG-LKVVSLSGQksfkkeQKLLLVDTSGRYLSRVdiLVATPGRLVDHLNStPGFTLKHLRFLVID 158
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568909597 354 EADTMLKMGFQQ---QVLD-----------------VLEHTPGDCQTILVSATIPDSIEQLTDQLLHNP 402
Cdd:cd17956 159 EADRLLNQSFQDwleTVMKalgrptapdlgsfgdanLLERSVRPLQKLLFSATLTRDPEKLSSLKLHRP 227
|
|
| DEADc_DDX21_DDX50 |
cd17944 |
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and ... |
216-389 |
1.87e-31 |
|
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and nucleolar RNA helicase 2) is an RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II. It promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) and binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs. DDX50 (also called Gu-Beta, Nucleolar Protein Gu2, and malignant cell derived RNA helicase). DDX21 and DDX50 have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. Diseases associated with DDX21 include stomach disease and cerebral creatine deficiency syndrome 3. Diseases associated with DDX50 include rectal disease. Both are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. Their name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350702 [Multi-domain] Cd Length: 202 Bit Score: 121.11 E-value: 1.87e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 216 QNLKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIIRAFSEDKT------PSALILTPTRELAIQIer 289
Cdd:cd17944 3 KLLQARGVTYLFPIQVKTFHPVYSGKDLIAQARTGTGKTFSFAIPLIEKLQEDQQPrkrgraPKVLVLAPTRELANQV-- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 290 qAKELMSGLPRMKTVLLVGGLPLPPQLYRLRQHVKVIIATPGRLLDIIKQSSVSLSGIKIVVVDEADTMLKMGFQQQVLD 369
Cdd:cd17944 81 -TKDFKDITRKLSVACFYGGTPYQQQIFAIRNGIDILVGTPGRIKDHLQNGRLDLTKLKHVVLDEVDQMLDMGFAEQVEE 159
|
170 180
....*....|....*....|....*...
gi 568909597 370 VL--------EHTPgdcQTILVSATIPD 389
Cdd:cd17944 160 ILsvsykkdsEDNP---QTLLFSATCPD 184
|
|
| DEADc_DDX25 |
cd18048 |
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated ... |
191-402 |
6.70e-24 |
|
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH) is a testis-specific protein essential for completion of spermatogenesis. DDX25 is also a novel negative regulator of IFN pathway and facilitates RNA virus infection. Diseases associated with DDX25 include hydrolethalus syndrome, an autosomal recessive lethal malformation syndrome characterized by multiple developmental defects of fetus.. DDX25 (also called gonadotropin-regulated testicular RNA helicase) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350806 [Multi-domain] Cd Length: 229 Bit Score: 100.48 E-value: 6.70e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 191 ISVQGQDVARPIID---FEHCGFPETLNQNLKKSGYEVPTPIQMQMIPVGLLG--RDILASADTGSGKTAAFLLPVIIRA 265
Cdd:cd18048 3 VEVLQRDPTSPLFSvksFEELHLKEELLRGIYAMGFNRPSKIQENALPMMLADppQNLIAQSQSGTGKTAAFVLAMLSRV 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 266 FSEDKTPSALILTPTRELAIQIERQAKELMSGLPRMKTVLLVGGlPLPPQLYRLRQhvKVIIATPGRLLD-IIKQSSVSL 344
Cdd:cd18048 83 DALKLYPQCLCLSPTFELALQTGKVVEEMGKFCVGIQVIYAIRG-NRPGKGTDIEA--QIVIGTPGTVLDwCFKLRLIDV 159
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 568909597 345 SGIKIVVVDEADTMLKM-GFQQQVLDVLEHTPGDCQTILVSATIPDSIEQLTDQLLHNP 402
Cdd:cd18048 160 TNISVFVLDEADVMINVqGHSDHSVRVKRSMPKECQMLLFSATFEDSVWAFAERIVPDP 218
|
|
| DEADc_MRH4 |
cd17965 |
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 ... |
212-407 |
1.10e-20 |
|
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 (MRH4) plays an essential role during the late stages of mitochondrial ribosome or mitoribosome assembly by promoting remodeling of the 21S rRNA-protein interactions. MRH4 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350723 [Multi-domain] Cd Length: 251 Bit Score: 91.67 E-value: 1.10e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 212 ETLNQNLKKSGYEVPTPIQMQMIPVgLLGRDI-----------------LASADTGSGKTAAFLLPVI-------IRAFS 267
Cdd:cd17965 17 EILKGSNKTDEEIKPSPIQTLAIKK-LLKTLMrkvtkqtsneepklevfLLAAETGSGKTLAYLAPLLdylkrqeQEPFE 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 268 EDK----------TPSALILTPTRELAIQIERQAKELMSGLP-RMKTVLLVGGLPLPPQLYRLRQHVKVIIATPGRLLDI 336
Cdd:cd17965 96 EAEeeyesakdtgRPRSVILVPTHELVEQVYSVLKKLSHTVKlGIKTFSSGFGPSYQRLQLAFKGRIDILVTTPGKLASL 175
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568909597 337 IKQSSVSLSGIKIVVVDEADTMLKMGFQQQVLDVLEHTPGDCQTILVSATIPDSIEQLTDQLLHNPVRIIT 407
Cdd:cd17965 176 AKSRPKILSRVTHLVVDEADTLFDRSFLQDTTSIIKRAPKLKHLILCSATIPKEFDKTLRKLFPDVVRIAT 246
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
240-386 |
8.47e-20 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 85.92 E-value: 8.47e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 240 GRDILASADTGSGKTAAFLLPVIIRAfsEDKTPSALILTPTRELAIQierQAKELMSGLPRMKTV-LLVGGLPLPPQLYR 318
Cdd:cd00046 1 GENVLITAPTGSGKTLAALLAALLLL--LKKGKKVLVLVPTKALALQ---TAERLRELFGPGIRVaVLVGGSSAEEREKN 75
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568909597 319 LRQHVKVIIATPGRLLDIIKQS-SVSLSGIKIVVVDEADTMLKMGFQ--QQVLDVLEHTPGDCQTILVSAT 386
Cdd:cd00046 76 KLGDADIIIATPDMLLNLLLREdRLFLKDLKLIIVDEAHALLIDSRGalILDLAVRKAGLKNAQVILLSAT 146
|
|
| DEADc_DDX19 |
cd18047 |
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both ... |
205-402 |
3.12e-19 |
|
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both mRNA (mRNA) export from the nucleus into the cytoplasm and in mRNA translation. DDX19 functions in the nucleus in resolving RNA:DNA hybrids (R-loops). Activation of a DNA damage response pathway dependent upon the ATR kinase, a major regulator of replication fork progression, stimulates translocation of DDX19 from the cytoplasm into the nucleus. Only nuclear Ddx19 is competent to resolve R-loops. DDX19 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350805 [Multi-domain] Cd Length: 205 Bit Score: 86.31 E-value: 3.12e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 205 FEHCGFPETLNQNLKKSGYEVPTPIQMQMIPVGLLG--RDILASADTGSGKTAAFLLPVIIRAFSEDKTPSALILTPTRE 282
Cdd:cd18047 3 FEELRLKPQLLQGVYAMGFNRPSKIQENALPLMLAEppQNLIAQSQSGTGKTAAFVLAMLSQVEPANKYPQCLCLSPTYE 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 283 LAIQIERQAKELMSGLPRMKTVLLVGGlplppqlYRLRQHVK----VIIATPGRLLD-IIKQSSVSLSGIKIVVVDEADT 357
Cdd:cd18047 83 LALQTGKVIEQMGKFYPELKLAYAVRG-------NKLERGQKiseqIVIGTPGTVLDwCSKLKFIDPKKIKVFVLDEADV 155
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 568909597 358 ML-KMGFQQQVLDVLEHTPGDCQTILVSATIPDSIEQLTDQLLHNP 402
Cdd:cd18047 156 MIaTQGHQDQSIRIQRMLPRNCQMLLFSATFEDSVWKFAQKVVPDP 201
|
|
| zf-HIT_DDX59 |
cd23022 |
zinc finger HIT (zf-HIT) found in DEAD box protein 59 (DDX59) and similar proteins; DDX59, ... |
103-136 |
8.91e-18 |
|
zinc finger HIT (zf-HIT) found in DEAD box protein 59 (DDX59) and similar proteins; DDX59, also called zinc finger HIT domain-containing protein 5 (ZNHIT5), is a probable ATP-dependent RNA helicase (EC 3.6.4.13) that plays a role in nervous system development and function. It has an important role in lung cancer development through promoting DNA replication. Mutations in DDX59 implicate RNA helicase in the pathogenesis of oral-facial-digital syndrome (OFDS). DDX59 contains a zf-HIT domain which is characterized by a fold in "treble-clef" through interleaved CCCC and CCHC zinc finger motifs that both bind a zinc ion.
Pssm-ID: 467794 Cd Length: 35 Bit Score: 76.51 E-value: 8.91e-18
10 20 30
....*....|....*....|....*....|....
gi 568909597 103 PGEPVCVVCGRYGEYICDKTDEDVCSLECKAKHL 136
Cdd:cd23022 1 GKEGWCVVCGRYANYYCDDTDDPVCSLECKRKHL 34
|
|
| SF2_C_DEAD |
cd18787 |
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ... |
417-506 |
1.70e-14 |
|
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350174 [Multi-domain] Cd Length: 131 Bit Score: 70.23 E-value: 1.70e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 417 VRQIILWVEDPAKKKKLFEILnDQKLFKPPVLVFVDCKLGADLLSEAVQKItGLNSTSIHSEKSQVERRDILK------- 489
Cdd:cd18787 1 IKQLYVVVEEEEKKLLLLLLL-LEKLKPGKAIIFVNTKKRVDRLAELLEEL-GIKVAALHGDLSQEERERALKkfrsgkv 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 568909597 490 ------------------------------------VGRVGRLGQNGTAITFI 506
Cdd:cd18787 79 rvlvatdvaargldipgvdhvinydlprdaedyvhrIGRTGRAGRKGTAITFV 131
|
|
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
211-388 |
7.15e-13 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 71.08 E-value: 7.15e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 211 PETLNQNLKKSGYEVPTPIQMQMIPVGLL-GRDILASADTGSGKTA-AFLLpvIIRAFSEDKTpsALILTPTRELAIQIE 288
Cdd:COG1204 8 LEKVIEFLKERGIEELYPPQAEALEAGLLeGKNLVVSAPTASGKTLiAELA--ILKALLNGGK--ALYIVPLRALASEKY 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 289 RQAKELMSGLPrMKTVLLVGGLPLPPqlYRLRQHvKVIIATPGRLLDIIKQSSVSLSGIKIVVVDEAdtmlkmgfqQQVL 368
Cdd:COG1204 84 REFKRDFEELG-IKVGVSTGDYDSDD--EWLGRY-DILVATPEKLDSLLRNGPSWLRDVDLVVVDEA---------HLID 150
|
170 180 190
....*....|....*....|....*....|..
gi 568909597 369 D-----VLEHT-------PGDCQTILVSATIP 388
Cdd:COG1204 151 DesrgpTLEVLlarlrrlNPEAQIVALSATIG 182
|
|
| YprA |
COG1205 |
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ... |
240-493 |
7.09e-12 |
|
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];
Pssm-ID: 440818 [Multi-domain] Cd Length: 758 Bit Score: 68.32 E-value: 7.09e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 240 GRDILASADTGSGKTAAFLLPViIRAFSEDKTPSALILTPTRELAI-QIERQAKELMSGLPRMKTVLLVGGLPlPPQLYR 318
Cdd:COG1205 71 GKNVVIATPTASGKSLAYLLPV-LEALLEDPGATALYLYPTKALARdQLRRLRELAEALGLGVRVATYDGDTP-PEERRW 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 319 LRQHVKVIIATPgrllDIIKQSSVS--------LSGIKIVVVDEADT-----------MLKmgfqqQVLDVLEHTPGDCQ 379
Cdd:COG1205 149 IREHPDIVLTNP----DMLHYGLLPhhtrwarfFRNLRYVVIDEAHTyrgvfgshvanVLR-----RLRRICRHYGSDPQ 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 380 TILVSATIPDSIE---QLTDQllhnPVRIITGDKNlPCASvRQIILW----VEDPAKK------KKLFEILNDQKLfkpP 446
Cdd:COG1205 220 FILASATIGNPAEhaeRLTGR----PVTVVDEDGS-PRGE-RTFVLWnpplVDDGIRRsalaeaARLLADLVREGL---R 290
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 447 VLVFVDCKLGADLLSEAVQKitglnSTSIHSEKSQV----------ERRDI---LKVGRV 493
Cdd:COG1205 291 TLVFTRSRRGAELLARYARR-----ALREPDLADRVaayragylpeERREIergLRSGEL 345
|
|
| DEXHc_LHR-like |
cd17922 |
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA ... |
240-389 |
2.15e-11 |
|
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases from the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350680 [Multi-domain] Cd Length: 166 Bit Score: 62.60 E-value: 2.15e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 240 GRDILASADTGSGKTAAFLLPVIIRAFSEDKTPSALI-LTPTRELAIQIERqakelmsglpRMKTVLLVGGLPLP----- 313
Cdd:cd17922 1 GRNVLIAAPTGSGKTEAAFLPALSSLADEPEKGVQVLyISPLKALINDQER----------RLEEPLDEIDLEIPvavrh 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 314 ---PQLYRLRQHVK---VIIATPGRL--LDIIKQSSVSLSGIKIVVVDEADTML--KMGFQ-QQVLDVLEH-TPGDCQTI 381
Cdd:cd17922 71 gdtSQSEKAKQLKNppgILITTPESLelLLVNKKLRELFAGLRYVVVDEIHALLgsKRGVQlELLLERLRKlTGRPLRRI 150
|
....*...
gi 568909597 382 LVSATIPD 389
Cdd:cd17922 151 GLSATLGN 158
|
|
| DEXHc_Hrq1-like |
cd17923 |
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a ... |
240-387 |
4.33e-11 |
|
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. Hrq1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350681 [Multi-domain] Cd Length: 182 Bit Score: 61.83 E-value: 4.33e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 240 GRDILASADTGSGKTAAFLLPvIIRAFSEDKTPSALILTPTRELAI-QIERQAKELMSGLPRMKTVLLVGGLPLPPQLYR 318
Cdd:cd17923 15 GRSVVVTTGTASGKSLCYQLP-ILEALLRDPGSRALYLYPTKALAQdQLRSLRELLEQLGLGIRVATYDGDTPREERRAI 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 319 LRQHVKVIIATPGRL-LDIIKQSSV---SLSGIKIVVVDEADTmLKMGFQQQV-------LDVLEHTPGDCQTILVSATI 387
Cdd:cd17923 94 IRNPPRILLTNPDMLhYALLPHHDRwarFLRNLRYVVLDEAHT-YRGVFGSHValllrrlRRLCRRYGADPQFILTSATI 172
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
227-398 |
1.09e-10 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 60.74 E-value: 1.09e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 227 TPIQMQMIPVGLL-GRDILASADTGSGKTAAFLLpVIIRAFSEDKtPSALILTPTRELAIQIERQAKELMSGLPrMKTVL 305
Cdd:cd17921 3 NPIQREALRALYLsGDSVLVSAPTSSGKTLIAEL-AILRALATSG-GKAVYIAPTRALVNQKEADLRERFGPLG-KNVGL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 306 LVGGLPLPPQLYRLRQhvkVIIATPGRLLDII-KQSSVSLSGIKIVVVDEADtMLKMGFQQQVL-DVLEHTP---GDCQT 380
Cdd:cd17921 80 LTGDPSVNKLLLAEAD---ILVATPEKLDLLLrNGGERLIQDVRLVVVDEAH-LIGDGERGVVLeLLLSRLLrinKNARF 155
|
170
....*....|....*...
gi 568909597 381 ILVSATIPDSiEQLTDQL 398
Cdd:cd17921 156 VGLSATLPNA-EDLAEWL 172
|
|
| zf-HIT |
cd23020 |
zinc finger HIT (zf-HIT) domain; The zinc finger HIT (zf-HIT) is a novel zinc-binding domain ... |
107-136 |
1.51e-09 |
|
zinc finger HIT (zf-HIT) domain; The zinc finger HIT (zf-HIT) is a novel zinc-binding domain with about 50 amino acids. It is characterized by a fold in "treble-clef" through interleaved CCCC and CCHC zinc finger motifs that both bind a zinc ion. zf-HIT domain may function as a protein-protein interaction domain. It is mainly found in nuclear proteins involved in gene regulation and chromatin remodeling. The zf-HIT family includes six proteins containing zf-HIT domain present in human and three in yeast proteome, all belonging to multimodular RNA/protein complexes.
Pssm-ID: 467792 Cd Length: 31 Bit Score: 53.27 E-value: 1.51e-09
10 20 30
....*....|....*....|....*....|.
gi 568909597 107 VCVVCGRY-GEYICDKTDEDVCSLECKAKHL 136
Cdd:cd23020 1 TCGICGGYpGKYKCPRCGVPYCSLECYRKHL 31
|
|
| Lhr |
COG1201 |
Lhr-like helicase [Replication, recombination and repair]; |
223-427 |
1.95e-09 |
|
Lhr-like helicase [Replication, recombination and repair];
Pssm-ID: 440814 [Multi-domain] Cd Length: 850 Bit Score: 60.50 E-value: 1.95e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 223 YEVPTPIQMQMIPVGLLGRDILASADTGSGKT-AAFlLPVIIRAFSEDKTPSA------LILTPTRELAIQIERQAKELM 295
Cdd:COG1201 22 FGAPTPPQREAWPAIAAGESTLLIAPTGSGKTlAAF-LPALDELARRPRPGELpdglrvLYISPLKALANDIERNLRAPL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 296 SGLprmktvLLVGGLPLP-----------PQLYRLRQ-----HvkVIIATP-----------GRLLdiikqssvsLSGIK 348
Cdd:COG1201 101 EEI------GEAAGLPLPeirvgvrtgdtPASERQRQrrrppH--ILITTPeslallltspdAREL---------LRGVR 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 349 IVVVDE----ADTmlKMGFQQQV-LDVLEH-TPGDCQTILVSATIpDSIEQ----LTDQLLHNPVRIITGDknlpcaSVR 418
Cdd:COG1201 164 TVIVDEihalAGS--KRGVHLALsLERLRAlAPRPLQRIGLSATV-GPLEEvarfLVGYEDPRPVTIVDAG------AGK 234
|
....*....
gi 568909597 419 QIILWVEDP 427
Cdd:COG1201 235 KPDLEVLVP 243
|
|
| DEXHc_dicer |
cd18034 |
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded ... |
241-355 |
4.02e-08 |
|
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicers exist throughout eukaryotes, and a subset have an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350792 [Multi-domain] Cd Length: 200 Bit Score: 53.81 E-value: 4.02e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 241 RDILASADTGSGKT--AAFLlpviIRAFSEDKTPS------ALILTPTRELAIQierQAKELmsglpRMKTVLLVG---- 308
Cdd:cd18034 17 RNTIVVLPTGSGKTliAVML----IKEMGELNRKEknpkkrAVFLVPTVPLVAQ---QAEAI-----RSHTDLKVGeysg 84
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 568909597 309 --GLPLPPQLY---RLRQHvKVIIATPGRLLDIIKQSSVSLSGIKIVVVDEA 355
Cdd:cd18034 85 emGVDKWTKERwkeELEKY-DVLVMTAQILLDALRHGFLSLSDINLLIFDEC 135
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
240-489 |
8.84e-07 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 51.95 E-value: 8.84e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 240 GRDILASADTGSGKTAAFLLpvIIRAFSEDKTpsALILTPTRELAIQIerqAKELMSGLPRmktVLLVGGlplppqlyRL 319
Cdd:COG1061 100 GGRGLVVAPTGTGKTVLALA--LAAELLRGKR--VLVLVPRRELLEQW---AEELRRFLGD---PLAGGG--------KK 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 320 RQHVKVIIATPGRLldiIKQSSVSL--SGIKIVVVDE-----ADTmlkmgFQQqvldVLEH-----------TP------ 375
Cdd:COG1061 162 DSDAPITVATYQSL---ARRAHLDElgDRFGLVIIDEahhagAPS-----YRR----ILEAfpaayrlgltaTPfrsdgr 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 376 ----GDCQTILVSATIPDSIEqltDQLLHNPVRII--------TGDKNLPCASVRQIILwVEDPAKKKKLFEILnDQKLF 443
Cdd:COG1061 230 eillFLFDGIVYEYSLKEAIE---DGYLAPPEYYGirvdltdeRAEYDALSERLREALA-ADAERKDKILRELL-REHPD 304
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 568909597 444 KPPVLVFVDCKLGADLLSEAVQKItGLNSTSIHSEKSQVERRDILK 489
Cdd:COG1061 305 DRKTLVFCSSVDHAEALAELLNEA-GIRAAVVTGDTPKKEREEILE 349
|
|
| DEXHc_RecG |
cd17918 |
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase ... |
241-393 |
8.89e-07 |
|
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase RecG family is part of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350676 [Multi-domain] Cd Length: 180 Bit Score: 49.34 E-value: 8.89e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 241 RDILASADTGSGKTAAFLLPvIIRAFSEDKtpSALILTPTRELAIQIERQAKELmsgLPRMKTVLLVGGlplppQLYRLR 320
Cdd:cd17918 37 MDRLLSGDVGSGKTLVALGA-ALLAYKNGK--QVAILVPTEILAHQHYEEARKF---LPFINVELVTGG-----TKAQIL 105
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568909597 321 QHVKVIIATPGRLLDIIKQSSVSLsgikiVVVDEADtmlKMGF-QQQVLDVLehtpGDCQTILVSAT-IPDSIEQ 393
Cdd:cd17918 106 SGISLLVGTHALLHLDVKFKNLDL-----VIVDEQH---RFGVaQREALYNL----GATHFLEATATpIPRTLAL 168
|
|
| zf-HIT |
pfam04438 |
HIT zinc finger; This presumed zinc finger contains up to 6 cysteine residues that could ... |
105-132 |
1.10e-06 |
|
HIT zinc finger; This presumed zinc finger contains up to 6 cysteine residues that could coordinate zinc. The domain is named after the HIT protein. This domain is also found in the Thyroid receptor interacting protein 3 (TRIP-3) that specifically interact with the ligand binding domain of the thyroid receptor.
Pssm-ID: 461310 Cd Length: 30 Bit Score: 44.93 E-value: 1.10e-06
10 20
....*....|....*....|....*...
gi 568909597 105 EPVCVVCGRYGEYICDKTDEDVCSLECK 132
Cdd:pfam04438 2 RKLCSVCGNPSKYRCPRCGVRYCSLECY 29
|
|
| PRK13767 |
PRK13767 |
ATP-dependent helicase; Provisional |
220-387 |
3.73e-05 |
|
ATP-dependent helicase; Provisional
Pssm-ID: 237497 [Multi-domain] Cd Length: 876 Bit Score: 46.80 E-value: 3.73e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 220 KSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKT-AAFL--LPVIIRAFSEDKTPS---ALILTPTRELAIQIERQAKE 293
Cdd:PRK13767 27 KEKFGTFTPPQRYAIPLIHEGKNVLISSPTGSGKTlAAFLaiIDELFRLGREGELEDkvyCLYVSPLRALNNDIHRNLEE 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 294 LMSGLprmKTVLLVGGLPLPPqlyrLRQHVK------------------VIIATPgRLLDIIKQS---SVSLSGIKIVVV 352
Cdd:PRK13767 107 PLTEI---REIAKERGEELPE----IRVAIRtgdtssyekqkmlkkpphILITTP-ESLAILLNSpkfREKLRTVKWVIV 178
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 568909597 353 DE----ADTmlKMGFQQQV-LDVLEH-TPGDCQTILVSATI 387
Cdd:PRK13767 179 DEihslAEN--KRGVHLSLsLERLEElAGGEFVRIGLSATI 217
|
|
| DEXDc_FANCM |
cd18033 |
DEAH-box helicase domain of FANCM; Fanconi anemia group M (FANCM) protein is a DNA-dependent ... |
249-355 |
8.68e-05 |
|
DEAH-box helicase domain of FANCM; Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. It is required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, it binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA), and Holliday junction substrates. Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This activity is strongly stimulated in the presence of CENPS and CENPX. In complex with FAAP24, it efficiently binds to single-strand DNA (ssDNA), splayed-arm DNA, and 3'-flap substrates. In vitro, on its own, it strongly binds ssDNA oligomers and weakly fsDNA, but does not bind to dsDNA. FANCM is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350791 [Multi-domain] Cd Length: 182 Bit Score: 43.47 E-value: 8.68e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 249 TGSGKT--AAFLLPVIIRAFSEDKtpsALILTPTRELAIQiERQAKELMSGLPRMKTVLLVGGLPlPPQLYRLRQHVKVI 326
Cdd:cd18033 25 TGLGKTfiAAVVMLNYYRWFPKGK---IVFMAPTKPLVSQ-QIEACYKITGIPSSQTAELTGSVP-PTKRAELWASKRVF 99
|
90 100
....*....|....*....|....*....
gi 568909597 327 IATPGRLLDIIKQSSVSLSGIKIVVVDEA 355
Cdd:cd18033 100 FLTPQTLENDLKEGDCDPKSIVCLVIDEA 128
|
|
| DEXHc_HFM1 |
cd18023 |
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box ... |
241-405 |
1.22e-04 |
|
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box helicase, required for crossover formation and complete synapsis of homologous chromosomes during meiosis. HFM1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350781 [Multi-domain] Cd Length: 206 Bit Score: 43.50 E-value: 1.22e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 241 RDILASADTGSGKTAAFLLpVIIRAFSEDKTPS-----ALILTPTRELAIQIERQAKELMsGLPRMKTVLLVGGlplpPQ 315
Cdd:cd18023 18 KNFVVSAPTGSGKTVLFEL-AILRLLKERNPLPwgnrkVVYIAPIKALCSEKYDDWKEKF-GPLGLSCAELTGD----TE 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 316 LYRLR--QHVKVIIATPGRlLDII----KQSSVSLSGIKIVVVDEADT-----------------MLKMGFQQQVLDVLe 372
Cdd:cd18023 92 MDDTFeiQDADIILTTPEK-WDSMtrrwRDNGNLVQLVALVLIDEVHIikenrgatlevvvsrmkTLSSSSELRGSTVR- 169
|
170 180 190
....*....|....*....|....*....|...
gi 568909597 373 htpgDCQTILVSATIPDsIEQLTDQLLHNPVRI 405
Cdd:cd18023 170 ----PMRFVAVSATIPN-IEDLAEWLGDNPAGC 197
|
|
| PRK09751 |
PRK09751 |
putative ATP-dependent helicase Lhr; Provisional |
247-387 |
5.27e-04 |
|
putative ATP-dependent helicase Lhr; Provisional
Pssm-ID: 137505 [Multi-domain] Cd Length: 1490 Bit Score: 42.99 E-value: 5.27e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 247 ADTGSGKTAAFLLPVIIRAFSED----------KTPSALILTPTRELAIQIERQAKELMSGLPRMK----------TV-L 305
Cdd:PRK09751 3 APTGSGKTLAAFLYALDRLFREGgedtreahkrKTSRILYISPIKALGTDVQRNLQIPLKGIADERrrrgetevnlRVgI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 306 LVGGLPLPPQLYRLRQHVKVIIATPGRL-LDIIKQSSVSLSGIKIVVVDEADTML------KMGFQQQVLDVLEHTPGdc 378
Cdd:PRK09751 83 RTGDTPAQERSKLTRNPPDILITTPESLyLMLTSRARETLRGVETVIIDEVHAVAgskrgaHLALSLERLDALLHTSA-- 160
|
....*....
gi 568909597 379 QTILVSATI 387
Cdd:PRK09751 161 QRIGLSATV 169
|
|
| DinG |
COG1199 |
Rad3-related DNA helicase DinG [Replication, recombination and repair]; |
240-308 |
5.47e-04 |
|
Rad3-related DNA helicase DinG [Replication, recombination and repair];
Pssm-ID: 440812 [Multi-domain] Cd Length: 629 Bit Score: 42.99 E-value: 5.47e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568909597 240 GRDILASADTGSGKTAAFLLPVIIRAFSEDKTpsALILTPTRELAIQI-ERQAKELMSGLPR-MKTVLLVG 308
Cdd:COG1199 33 GRHLLIEAGTGTGKTLAYLVPALLAARETGKK--VVISTATKALQEQLvEKDLPLLRKALGLpLRVALLKG 101
|
|
| DEXHc_RIG-I |
cd17927 |
DEXH-box helicase domain of DEAD-like helicase RIG-I family proteins; Members of the RIG-I ... |
226-355 |
6.36e-04 |
|
DEXH-box helicase domain of DEAD-like helicase RIG-I family proteins; Members of the RIG-I family include FANCM, dicer, Hef, and the RIG-I-like receptors. Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). Hef (helicase-associated endonuclease fork-structure) is involved in stalled replication fork repair. RIG-I-like receptors (RLRs) sense cytoplasmic viral RNA and comprises RIG-I, RLR-2/MDA5 (melanoma differentiation-associated protein 5) and RLR-3/LGP2 (laboratory of genetics and physiology 2). The RIG-I family is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350685 [Multi-domain] Cd Length: 201 Bit Score: 41.26 E-value: 6.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 226 PTPIQMQMIPVGLLGRDILASADTGSGKT--AAFLLPVIIRAFSEDKTPSALILTPTRELAIQIERQAKELMsGLPRMKT 303
Cdd:cd17927 3 PRNYQLELAQPALKGKNTIICLPTGSGKTfvAVLICEHHLKKFPAGRKGKVVFLANKVPLVEQQKEVFRKHF-ERPGYKV 81
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 568909597 304 VLLVGGLPLPPQLYRLRQHVKVIIATPGRLLDIIKQ-SSVSLSGIKIVVVDEA 355
Cdd:cd17927 82 TGLSGDTSENVSVEQIVESSDVIIVTPQILVNDLKSgTIVSLSDFSLLVFDEC 134
|
|
| PRK13766 |
PRK13766 |
Hef nuclease; Provisional |
249-355 |
8.07e-04 |
|
Hef nuclease; Provisional
Pssm-ID: 237496 [Multi-domain] Cd Length: 773 Bit Score: 42.55 E-value: 8.07e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 249 TGSGKTAAFLLpvIIRAFSEDKTPSALILTPTRELAIQIERQAKELMSgLPRMKTVLLVGGLPlPPQLYRLRQHVKVIIA 328
Cdd:PRK13766 38 TGLGKTAIALL--VIAERLHKKGGKVLILAPTKPLVEQHAEFFRKFLN-IPEEKIVVFTGEVS-PEKRAELWEKAKVIVA 113
|
90 100 110
....*....|....*....|....*....|....*.
gi 568909597 329 TP---------GRlldiIKQSSVSLsgikiVVVDEA 355
Cdd:PRK13766 114 TPqviendliaGR----ISLEDVSL-----LIFDEA 140
|
|
| DEXHc_Hef |
cd18035 |
DEXH-box helicase domain of Hef; Hef (helicase-associated endonuclease fork-structure) belongs ... |
229-355 |
1.13e-03 |
|
DEXH-box helicase domain of Hef; Hef (helicase-associated endonuclease fork-structure) belongs to the XPF/MUS81/FANCM family of endonucleases and is involved in stalled replication fork repair. All archaea encode a protein of the XPF/MUS81/FANCM family of endonucleases. It exists in two forms: a long form, referred as Hef which consists of an N-terminal helicase fused to a C-terminal nuclease and is specific to euryarchaea and a short form, referred as XPF which lacks the helicase domain and is specific to crenarchaea and thaumarchaea. Hef has the unique feature of having both active helicase and nuclease domains. This domain configuration is highly similar with the human FANCM, a possible ortholog of archaeal Hef proteins. Hef is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350793 [Multi-domain] Cd Length: 181 Bit Score: 40.19 E-value: 1.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 229 IQMQMIPVGLLGRDILASADTGSGKTAAFLLpvIIRAFSEDKTPSALILTPTRELAIQIERQAKELMSglPRMKTVLLVG 308
Cdd:cd18035 5 LYQVLIAAVALNGNTLIVLPTGLGKTIIAIL--VAADRLTKKGGKVLILAPSRPLVEQHAENLKRVLN--IPDKITSLTG 80
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 568909597 309 GLPlPPQLYRLRQHVKVIIATPGRLLDIIKQSSVSLSGIKIVVVDEA 355
Cdd:cd18035 81 EVK-PEERAERWDASKIIVATPQVIENDLLAGRITLDDVSLLIFDEA 126
|
|
| ResIII |
pfam04851 |
Type III restriction enzyme, res subunit; |
249-355 |
4.81e-03 |
|
Type III restriction enzyme, res subunit;
Pssm-ID: 398492 [Multi-domain] Cd Length: 162 Bit Score: 38.04 E-value: 4.81e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 249 TGSGKT--AAFLlpvIIRAFSEDKTPSALILTPTRELAIQIERQAKELMSGlPRMKTVLLVGGLPLPPqlyrlRQHVKVI 326
Cdd:pfam04851 32 TGSGKTltAAKL---IARLFKKGPIKKVLFLVPRKDLLEQALEEFKKFLPN-YVEIGEIISGDKKDES-----VDDNKIV 102
|
90 100 110
....*....|....*....|....*....|.
gi 568909597 327 IATPGRLLDIIKQSSVSLSG--IKIVVVDEA 355
Cdd:pfam04851 103 VTTIQSLYKALELASLELLPdfFDVIIIDEA 133
|
|
| DEXHc_RecQ4-like |
cd18018 |
DEAH-box helicase domain of RecQ4 and similar proteins; ATP-dependent DNA helicase Q4 (RecQ4) ... |
228-355 |
5.01e-03 |
|
DEAH-box helicase domain of RecQ4 and similar proteins; ATP-dependent DNA helicase Q4 (RecQ4) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Mutations cause Rothmund-Thomson/RAPADILINO/Baller-Gerold syndrome.
Pssm-ID: 350776 [Multi-domain] Cd Length: 201 Bit Score: 38.39 E-value: 5.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 228 PIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIIRAfseDKTPS-ALILTPTRELaiqIERQakelMSGLPR-MKTVL 305
Cdd:cd18018 15 PGQEEAIARLLSGRSTLVVLPTGAGKSLCYQLPALLLR---RRGPGlTLVVSPLIAL---MKDQ----VDALPRaIKAAA 84
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 568909597 306 LVGGLPLPPQLYRLRQ----HVKVIIATPGRLLD-----IIKQSsvslSGIKIVVVDEA 355
Cdd:cd18018 85 LNSSLTREERRRILEKlragEVKILYVSPERLVNesfreLLRQT----PPISLLVVDEA 139
|
|
| DEXHc_RecQ |
cd17920 |
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box ... |
222-408 |
5.12e-03 |
|
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box helicase superfamily is a family of highly conserved DNA repair helicases. This domain contains the ATP-binding region.
Pssm-ID: 350678 [Multi-domain] Cd Length: 200 Bit Score: 38.67 E-value: 5.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 222 GYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIIRAfsedktPSALILTPTreLAIQierqaKELMSGLPRM 301
Cdd:cd17920 9 GYDEFRPGQLEAINAVLAGRDVLVVMPTGGGKSLCYQLPALLLD------GVTLVVSPL--ISLM-----QDQVDRLQQL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 302 --KTVLLVGGLPLPPQLYRLRQH----VKVIIATPGRL-----LDIIkQSSVSLSGIKIVVVDEADT-----------ML 359
Cdd:cd17920 76 giRAAALNSTLSPEEKREVLLRIkngqYKLLYVTPERLlspdfLELL-QRLPERKRLALIVVDEAHCvsqwghdfrpdYL 154
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 568909597 360 KMGfqqQVLDVLEHTPgdcqTILVSATIPDSIEQ-LTDQL-LHNPVRIITG 408
Cdd:cd17920 155 RLG---RLRRALPGVP----ILALTATATPEVREdILKRLgLRNPVIFRAS 198
|
|
| zf-HIT_ZNHIT1_like |
cd21437 |
HIT zinc finger found in zinc finger HIT domain-containing protein 1 (ZNHIT1) and similar ... |
108-135 |
6.48e-03 |
|
HIT zinc finger found in zinc finger HIT domain-containing protein 1 (ZNHIT1) and similar proteins; The family includes ZNHIT1 and its yeast counterpart, the vacuolar protein sorting-associated protein 71 (Vps71p). ZNHIT1, also known as cyclin-G1-binding protein 1 (CGBP1), zinc finger protein subfamily 4A member 1 (ZNFN4A1), or p18 Hamlet, may have a role in inducing apoptosis through p53 signaling. It binds to Rev-erb beta and releases its inhibitory effect on the transcription of apolipoprotein C3 (APOC3) without affecting its DNA-binding activity. The yeast counterpart Vps71p, also referred to as SWR complex protein 6 (Swc6p), plays a role in the exchange of histone H2A for the H2A variant HZT1, a euchromatin-specific factor, leading to chromatin remodeling and transcriptional changes of targeted genes. It is indirectly involved in vacuolar protein sorting. Members of this family contain a zf-HIT domain characterized by a "treble-clef" fold through interleaved CCCC and CCHC zinc finger motifs, both of which bind a zinc ion.
Pssm-ID: 467791 Cd Length: 43 Bit Score: 34.90 E-value: 6.48e-03
10 20
....*....|....*....|....*...
gi 568909597 108 CVVCGRYGEYICDKTDEDVCSLECKAKH 135
Cdd:cd21437 10 CSVCGYWGKYTCVRCGARYCSLKCLETH 37
|
|
| DDXDc_reverse_gyrase |
cd17924 |
DDXD-box helicase domain of reverse gyrase; Reverse gyrase modifies the topological state of ... |
219-395 |
8.27e-03 |
|
DDXD-box helicase domain of reverse gyrase; Reverse gyrase modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. Reverse gyrase belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350682 [Multi-domain] Cd Length: 189 Bit Score: 37.69 E-value: 8.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 219 KKSGYEvPTPIQMQMIPVGLLGRDILASADTGSGKTAaFLLpvIIRAFSEDKTPSALILTPTRELAIQIERQAKElMSGL 298
Cdd:cd17924 12 KKTGFP-PWGAQRTWAKRLLRGKSFAIIAPTGVGKTT-FGL--ATSLYLASKGKRSYLIFPTKSLVKQAYERLSK-YAEK 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568909597 299 PRMKTVLLV--GGLPLPPQ---LYRLRQ-HVKVIIATPGRLLDIIKQssvsLSGIK--IVVVDEADTMLKMGfqqQVLDV 370
Cdd:cd17924 87 AGVEVKILVyhSRLKKKEKeelLEKIEKgDFDILVTTNQFLSKNFDL----LSNKKfdFVFVDDVDAVLKSS---KNIDR 159
|
170 180
....*....|....*....|....*.
gi 568909597 371 LEHTPGDCQTILVSATI-PDSIEQLT 395
Cdd:cd17924 160 LLKLLGFGQLVVSSATGrPRGIRPLL 185
|
|
| |
