first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578807774  99 RRDYYDDFLQRLLEQGIHSDVVFVVHGKPFRVHRCVLGARSAYFANMLDTKWKGKSVVVLRHPLINPVAFGALLQYLYTG 178
Cdd:cd18295    2 RRDYYDEFLRRLLEQGSYSDVTFNVHGESFPAHRCILSARSPYFAEMFETKWKDKREINLKHPLVNPDAFRALLQYLYTG 81

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 578807774 179 RLDIGVEHVSDCERLAKQCQLWDLLSDLEAKCEKVSEF 216
Cdd:cd18295   82 RLEIHVDDVEDCKRLAKQCRLEELIEELEAKCKKVREF 119

BACK (BTB and C-terminal Kelch) domain found in ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein, or Bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homologue (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 578807774 378 LDEDTVVGVWRVAKLFRLARLEDQCTEYMAKVIEKLVEREDFVEAVKEEAAAVAARQETDSIPLVDDIRFHV 449
Cdd:cd18497    1 LDEDNVIDVLRTARLFNLPRLEDQCTEFMAKNLEELVDDEEFAELVREDAASVKNRQETDSIPIIDDIRYHL 72

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578807774  99 RRDYYDDFLQRLLEQGIHSDVVFVVHGKPFRVHRCVLGARSAYFANMLDTKWKGKSVVVLRHPLINPVAFGALLQYLYTG 178
Cdd:cd18295    2 RRDYYDEFLRRLLEQGSYSDVTFNVHGESFPAHRCILSARSPYFAEMFETKWKDKREINLKHPLVNPDAFRALLQYLYTG 81

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 578807774 179 RLDIGVEHVSDCERLAKQCQLWDLLSDLEAKCEKVSEF 216
Cdd:cd18295   82 RLEIHVDDVEDCKRLAKQCRLEELIEELEAKCKKVREF 119

BACK (BTB and C-terminal Kelch) domain found in ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein, or Bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homologue (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 578807774 378 LDEDTVVGVWRVAKLFRLARLEDQCTEYMAKVIEKLVEREDFVEAVKEEAAAVAARQETDSIPLVDDIRFHV 449
Cdd:cd18497    1 LDEDNVIDVLRTARLFNLPRLEDQCTEFMAKNLEELVDDEEFAELVREDAASVKNRQETDSIPIIDDIRYHL 72

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578807774   275 DICFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEEPAtsggppaVTLHGISPDVFTHVLYYMYSDHTELSPEAAYDV 354
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSE-------IYLDDVSPEDFRALLNFLYTGKLDLPEENVEEL 73

                           90       100
                   ....*....|....*....|....
gi 578807774   355 LSVADMYLLPGLKRLCGRSLAQML 378
Cdd:smart00225  74 LELADYLQIPGLVELCEEFLLKLL 97

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578807774   118 DVVFVVHGKPFRVHRCVLGARSAYFANMLDTKWK--GKSVVVLRHplINPVAFGALLQYLYTGRLDIGVEHVSDCERLAK 195
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKesDKSEIYLDD--VSPEDFRALLNFLYTGKLDLPEENVEELLELAD 78

                           90
                   ....*....|....*..
gi 578807774   196 QCQLWDLLSDLEAKCEK 212
Cdd:smart00225  79 YLQIPGLVELCEEFLLK 95

kelch-like protein; Provisional

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578807774 273 CPD-ICFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEepatsggppaVTLHgISPDVFTHVLYYMYSDHTELSPEAA 351
Cdd:PHA03098  10 CDEsIIIVNGGGIIKVHKIILSSSSEYFKKMFKNNFKENE----------INLN-IDYDSFNEVIKYIYTGKINITSNNV 78

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 578807774 352 YDVLSVADMYLLPGLKRLCGRSLAQMLDEDTVVGVWRVAKLFRLARLEDQCTEYMAKVIEKLVEREDF 419
Cdd:PHA03098  79 KDILSIANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDF 146

ankyrin-like protein; Provisional

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 578807774  29 VEVNVRDKWDSTPLYYACLCGHEELVLYLLANGARCEANTFDGERCLYGALSDPIRRALR 88
Cdd:PHA03095 248 ISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVR 307

kelch-like protein; Provisional

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578807774 119 VVFVVHGKPFRVHRCVLGARSAYFANMLDTKWKGKSVVVlrhpLINPVAFGALLQYLYTGRLDIGVEHVSDCERLAKQCQ 198
Cdd:PHA03098  14 IIIVNGGGIIKVHKIILSSSSEYFKKMFKNNFKENEINL----NIDYDSFNEVIKYIYTGKINITSNNVKDILSIANYLI 89

                 ....*
gi 578807774 199 LWDLL 203
Cdd:PHA03098  90 IDFLI 94

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578807774  99 RRDYYDDFLQRLLEQGIHSDVVFVVHGKPFRVHRCVLGARSAYFANMLDTKWKGKSVVVLRHPLINPVAFGALLQYLYTG 178
Cdd:cd18295    2 RRDYYDEFLRRLLEQGSYSDVTFNVHGESFPAHRCILSARSPYFAEMFETKWKDKREINLKHPLVNPDAFRALLQYLYTG 81

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 578807774 179 RLDIGVEHVSDCERLAKQCQLWDLLSDLEAKCEKVSEF 216
Cdd:cd18295   82 RLEIHVDDVEDCKRLAKQCRLEELIEELEAKCKKVREF 119

BACK (BTB and C-terminal Kelch) domain found in ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein, or Bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homologue (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 578807774 378 LDEDTVVGVWRVAKLFRLARLEDQCTEYMAKVIEKLVEREDFVEAVKEEAAAVAARQETDSIPLVDDIRFHV 449
Cdd:cd18497    1 LDEDNVIDVLRTARLFNLPRLEDQCTEFMAKNLEELVDDEEFAELVREDAASVKNRQETDSIPIIDDIRYHL 72

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578807774 275 DICFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEEPAtsggppaVTLHGISPDVFTHVLYYMYSDHTELSPEAAYDV 354
Cdd:cd18186    3 DVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKESSSSE-------IELDDVSPEAFEALLDYIYTGELELSEENVEEL 75

                 ....*..
gi 578807774 355 LSVADMY 361
Cdd:cd18186   76 LAAADKL 82

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578807774  107 LQRLLEQGIHSDVVFVVHGKPFRVHRCVLGARSAYFANMLDTKWKGKSVVVLRHPLINPVAFGALLQYLYTGRL 180
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGKL 74

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578807774 272 SCPDICFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEEPAtsggppaVTLHGISPDVFTHVLYYMYSDHTELSPEAA 351
Cdd:cd18314    5 EFSDVVLCVGDRKFFAHRIVLCARSPVFRSMLTGSMIESNLKE-------VTLEDVEPEIFETVLKYMYTGQVTLSEENV 77

                         90
                 ....*....|....*....
gi 578807774 352 YDVLSVADMYLLPGLKRLC 370
Cdd:cd18314   78 LDLLMLASKYQVPDLEKLC 96

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578807774 275 DICFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEepatsggPPAVTLHGISPDVFTHVLYYMYSDHTE---LSPEAA 351
Cdd:cd18297   14 DVTFLVEGRPFYAHKIVLVTASDRFKSMLSSGSTEAQ-------TPVIEIPDIRYDIFQLMMQYLYTGGVEsldVAQDDA 86

                         90       100       110
                 ....*....|....*....|....*....|.
gi 578807774 352 YDVLSVADMYLLPGLKRLCGRSLAQMLDEDT 382
Cdd:cd18297   87 LELLRAASFFQLDGLKRHCEILLSQQIDLDN 117

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578807774 275 DICFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEepatsggPPAVTLHGISPDVFTHVLYYMYSDHTELSPEAAYDV 354
Cdd:cd18352   15 DVTFLVEGRRFYAHRIALLASSDAFRAMFDGGYREKE-------ARDIEIPNIRWEVFELMMRFIYTGSVDITNDIAKDL 87

                         90       100
                 ....*....|....*....|....*....
gi 578807774 355 LSVADMYLLPGLKRLCGRSLAQMLDEDTV 383
Cdd:cd18352   88 LRAADQYLLEGLKRLCEYTIAQDLTLENI 116

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578807774   118 DVVFVVHGKPFRVHRCVLGARSAYFANMLDTKWK--GKSVVVLRHplINPVAFGALLQYLYTGRLDIGVEHVSDCERLAK 195
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKesDKSEIYLDD--VSPEDFRALLNFLYTGKLDLPEENVEELLELAD 78

                           90
                   ....*....|....*..
gi 578807774   196 QCQLWDLLSDLEAKCEK 212
Cdd:smart00225  79 YLQIPGLVELCEEFLLK 95

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578807774 117 SDVVFVVHGKPFRVHRCVLGARSAYFANMLDTKWKGKSV--VVLRHplINPVAFGALLQYLYTGRLDIGVEHVSDCERLA 194
Cdd:cd18314    7 SDVVLCVGDRKFFAHRIVLCARSPVFRSMLTGSMIESNLkeVTLED--VEPEIFETVLKYMYTGQVTLSEENVLDLLMLA 84

                         90
                 ....*....|....*.
gi 578807774 195 KQCQlwdlLSDLEAKC 210
Cdd:cd18314   85 SKYQ----VPDLEKLC 96

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578807774 248 DCALPPELrGDLWElpfpcpdgfNSC-PDICFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEEpatsgGPpaVTLHG 326
Cdd:cd18279    2 ECRLAEDL-GNLWE---------NSRfTDCCLCVGGQEFQAHKAILAARSPVFSAMFEHEMEESKK-----NR--VEIND 64

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 578807774 327 ISPDVFTHVLYYMYSDHTELSPEAAYDVLSVADMYLLPGLKRLCGRSLAQMLDEDT 382
Cdd:cd18279   65 VDPEVFKEMMRFIYTGKAPNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVEN 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 578807774 108 QRLleQGIHSDVVFVVHGKPFRVHRCVLGARSAYFANMLDTKwkgKSVVVLRHPLINPVAFGALLQYLYTGRLDIGV 184
Cdd:cd18290   21 QRL--QGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNSS---RSAVVELPAAVQPQSFQQILSFCYTGRLSMNV 92

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 578807774 107 LQRLLEQGIHSDVVFVV--HGKPFRVHRCVLGARSAYFANMLDTKWKGKSVVVlRHPL--INPVAFGALLQYLYTGRL 180
Cdd:cd18294    5 MKSLINNPEFSDVKFLVgpERQEIFAHKCILAARCEVFRAMFLTGPQKESTQS-PLVLsdIEPEVFRAVLEFIYTNCV 81

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578807774 257 GDLWELPFpcpdgFNSCpdiCFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESeepatSGGPpaVTLHGISPDVFTHVL 336
Cdd:cd18344   15 GELWENSL-----FTDC---CLLVAGHEFRAHKAILAARSPVFRAMFEHEMEER-----LKNP--IEIHDLDPQVFKEMM 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 578807774 337 YYMYSDHTEL--SPEAAYDVLSVADMYLLPGLKRLCGRSLAQML 378
Cdd:cd18344   80 GFIYTGKAPHlhSHSMACDVLAAADKYGLEGLKVLCEDALCRNL 123

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578807774 107 LQRLLEQGIHSDVVFVV-HGKPFRVHRCVLGARSAYFANMLDTKwkgksVVVLRHPLINPVAFGALLQYLYTGRLDIgve 185
Cdd:cd18299    3 LRNLLHSPSCADVVFILqGGVRIFAHRIVLAAASSVFADLFLMM-----TVVTLDSDITPEAFRRVLEFLYTGVLDE--- 74

                         90       100       110
                 ....*....|....*....|....*....|
gi 578807774 186 hvsDCERLAKQCQLWDLL--SDLEAKCEKV 213
Cdd:cd18299   75 ---NEDDLKELKDAAELLelFDLVMMCTNV 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578807774 117 SDVVFVVHGKPFRVHRCVLGARSAYFANMLDTKWKGKSVVVLRHPLINPVAFGALLQYLYTGRLDIGVEHVSDCERL--- 193
Cdd:cd18297   13 SDVTFLVEGRPFYAHKIVLVTASDRFKSMLSSGSTEAQTPVIEIPDIRYDIFQLMMQYLYTGGVESLDVAQDDALELlra 92

                         90
                 ....*....|....*....
gi 578807774 194 AKQCQLWDLLSDLEAKCEK 212
Cdd:cd18297   93 ASFFQLDGLKRHCEILLSQ 111

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578807774 272 SCPDIC----FRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEEPAtsggppAVTLHgISPDVFTHVLYYMYSDHTELS 347
Cdd:cd18302    1 KHSDLYdvtiVSEDGKEFPCHKCVLVARLEYFHSMLSSSWIEASSCS------ALTMP-IPSDILEIILDYLYTDEASAV 73

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 578807774 348 P-----EAAYDVLSVADMYLLPGLKRLCGRSLAQML 378
Cdd:cd18302   74 KesqnvEFLCNVLVIADQLLITRLKEICEVALVELL 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578807774 107 LQRLLEQGIHSDVVFVVHGKPFRVHRCVLGARSAYFANMLDTKWKG---KSVVVLRHPLINPVAFGALLQYLYTGRLDIG 183
Cdd:cd18292    8 IAQLYNNEELSDIVLRVGGKVFHAHRLILAKSSDVFRVMLSNDWWSeskQSEIELVEDPECAAVFEKFLRYLYTGQISVN 87

                         90
                 ....*....|....*....
gi 578807774 184 VEHVSDCERLAKQCQLWDL 202
Cdd:cd18292   88 LETALPLLMLADKYNVTDL 106

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578807774 275 DICFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEEpatsggpPAVTLHGISPDVFTHVLYYMYSDHTELSPEA-AYD 353
Cdd:cd18300   11 DVTFIVEDGTIPAHKALLVARCDVMAAMFGGNFRESSA-------KEVELPGVSKETFLALLEYLYTDQAPILEDGdCVG 83

                         90
                 ....*....|....*..
gi 578807774 354 VLSVADMYLLPGLKRLC 370
Cdd:cd18300   84 LIVLANRLCLPRLVALC 100

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578807774 104 DDFLQRLLE-QGIHSDVVFVV-HGKPFRVHRCVLGARSAYFANMLDTKWKGKSVVVLRHPLINPV--------AFGALLQ 173
Cdd:cd18310    5 SDLENLLDSpDLFYSDAEIIVeGGRPVPVHRCILAARSPFFRDIFASAKAEGANTKPKLELRELIpggivgydAFMLVLS 84

                         90
                 ....*....|....*..
gi 578807774 174 YLYTGRLDIGVEHVSDC 190
Cdd:cd18310   85 YLYSGRLRLVPKEGSAC 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6); BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 578807774 107 LQRLLEQGIHSDVVFVVHGKPFRVHRCVLGARSAYFANMLDTKWKGKSVVVLRHPLINPVAFGALLQYLYTGRLDI 182
Cdd:cd18331   15 LNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSIFTDQLKCNLSVINLDPEINPEGFNILLDFMYTSRLNL 90

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578807774 116 HSDVVFVVHGKPFRVHRCVLGARSAYFANMLdTKWKGKSVVVLRHPLINPVAFGALLQYLYTGRLDIGVEHVSDCERLAK 195
Cdd:cd18315    1 LVDVTLACEGGSLKAHKLVLAAASPYFAALL-KETPPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAE 79