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Conserved domains on  [gi|611980830|ref|XP_007476285|]
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kelch repeat and BTB domain-containing protein 11 [Monodelphis domestica]

Protein Classification

kelch repeat and BTB domain-containing protein 11( domain architecture ID 13033288)

kelch repeat and BTB domain-containing protein 11 (KBTBD11) is a BTB-Kelch family protein

Gene Symbol:  KBTBD11
Gene Ontology:  GO:0005515
PubMed:  13678422|15544948|10603472|17120193

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BTB_POZ_KBTBD11 cd18275
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 228-330 2.19e-58

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11 is also called chronic myelogenous leukemia-associated protein (CMLAP) or Kelch domain-containing protein 7B, or KLHDC7C. It is a BTB-Kelch family protein whose function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


:

Pssm-ID: 349584 [Multi-domain]  Cd Length: 104  Bit Score: 193.09  E-value: 2.19e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 228 EEPDLVIEVAGHRIQAHKSVLAAKSDYFRARSSREILRVKGVSYSALRLLVDYLYTGHMGeVKQDNVAEVIAGARFLQMP 307
Cdd:cd18275    3 GEPDLVIEVSGQRIRAHKSVLAAKSDYFRARLSRDILKVKGLSYATLRLLVDYVYSGRMA-VSKDNVVEVVAGARFLQMP 81

                         90       100
                 ....*....|....*....|...
gi 611980830 308 CALQCATDAMRAQLTLGNCYQVL 330
Cdd:cd18275   82 CAAQCAVDAVRAQLCLGNCYEVL 104
BACK_KBTBD11_CMLAP cd18484
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 321-397 3.40e-41

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11, also termed chronic myelogenous leukemia-associated protein (CMLAP), or Kelch domain-containing protein 7B, or KLHDC7C, is a BTB-Kelch family protein. Its function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk; KBTBD11 may function as a tumor suppressor. KBTBD11 hypomethylation may also be a potential target for differentiating between the mostly fatal TCF3-HLF and curable TCF3-PBX1 pediatric acute lymphoblastic leukemia subtypes.


:

Pssm-ID: 350559  Cd Length: 77  Bit Score: 144.83  E-value: 3.40e-41
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 611980830 321 LTLGNCYQVLSLAKQQRLSELREAAYRFMSDHYLQVLREPSIYGRLTGSERDLILQRRMEAGRSCLLVAEINDVFER 397
Cdd:cd18484    1 LDLGNCYEVLTLAKKQRLNELREAAYKFMSDNYLQVLREPAVYGRLSGAERELILRRRLEAGRACLVVAELNDVFER 77
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
454-602 2.54e-24

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 103.31  E-value: 2.54e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 454 EWKVLTRLPEG-ANAkgcAMCILYNYLFLAGGILQGGPegrprlSDKVFCYNPVTDTWTTVRSLS-QPRSQLKLLALDGY 531
Cdd:COG3055    2 TWSSLPDLPTPrSEA---AAALLDGKVYVAGGLSGGSA------SNSFEVYDPATNTWSELAPLPgPPRHHAAAVAQDGK 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 532 LYAVGG--------ECLFSVERYDPRTDRWSAVAPLPKGgfAVAHEATTCNGEIYVSGG----SLFYRLLKYDPRRDEWQ 599
Cdd:COG3055   73 LYVFGGftganpssTPLNDVYVYDPATNTWTKLAPMPTP--RGGATALLLDGKIYVVGGwddgGNVAWVEVYDPATGTWT 150


                 ...
gi 611980830 600 ECP 602
Cdd:COG3055  151 QLA 153
 
Name Accession Description Interval E-value
BTB_POZ_KBTBD11 cd18275
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 228-330 2.19e-58

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11 is also called chronic myelogenous leukemia-associated protein (CMLAP) or Kelch domain-containing protein 7B, or KLHDC7C. It is a BTB-Kelch family protein whose function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349584 [Multi-domain]  Cd Length: 104  Bit Score: 193.09  E-value: 2.19e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 228 EEPDLVIEVAGHRIQAHKSVLAAKSDYFRARSSREILRVKGVSYSALRLLVDYLYTGHMGeVKQDNVAEVIAGARFLQMP 307
Cdd:cd18275    3 GEPDLVIEVSGQRIRAHKSVLAAKSDYFRARLSRDILKVKGLSYATLRLLVDYVYSGRMA-VSKDNVVEVVAGARFLQMP 81

                         90       100
                 ....*....|....*....|...
gi 611980830 308 CALQCATDAMRAQLTLGNCYQVL 330
Cdd:cd18275   82 CAAQCAVDAVRAQLCLGNCYEVL 104
BACK_KBTBD11_CMLAP cd18484
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 321-397 3.40e-41

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11, also termed chronic myelogenous leukemia-associated protein (CMLAP), or Kelch domain-containing protein 7B, or KLHDC7C, is a BTB-Kelch family protein. Its function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk; KBTBD11 may function as a tumor suppressor. KBTBD11 hypomethylation may also be a potential target for differentiating between the mostly fatal TCF3-HLF and curable TCF3-PBX1 pediatric acute lymphoblastic leukemia subtypes.


Pssm-ID: 350559  Cd Length: 77  Bit Score: 144.83  E-value: 3.40e-41
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 611980830 321 LTLGNCYQVLSLAKQQRLSELREAAYRFMSDHYLQVLREPSIYGRLTGSERDLILQRRMEAGRSCLLVAEINDVFER 397
Cdd:cd18484    1 LDLGNCYEVLTLAKKQRLNELREAAYKFMSDNYLQVLREPAVYGRLSGAERELILRRRLEAGRACLVVAELNDVFER 77
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
454-602 2.54e-24

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 103.31  E-value: 2.54e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 454 EWKVLTRLPEG-ANAkgcAMCILYNYLFLAGGILQGGPegrprlSDKVFCYNPVTDTWTTVRSLS-QPRSQLKLLALDGY 531
Cdd:COG3055    2 TWSSLPDLPTPrSEA---AAALLDGKVYVAGGLSGGSA------SNSFEVYDPATNTWSELAPLPgPPRHHAAAVAQDGK 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 532 LYAVGG--------ECLFSVERYDPRTDRWSAVAPLPKGgfAVAHEATTCNGEIYVSGG----SLFYRLLKYDPRRDEWQ 599
Cdd:COG3055   73 LYVFGGftganpssTPLNDVYVYDPATNTWTKLAPMPTP--RGGATALLLDGKIYVVGGwddgGNVAWVEVYDPATGTWT 150


                 ...
gi 611980830 600 ECP 602
Cdd:COG3055  151 QLA 153
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 231-321 5.32e-18

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 79.99  E-value: 5.32e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830  231 DLVIEVAGHRIQAHKSVLAAKSDYFRA-------RSSREILRVKGVSYSALRLLVDYLYTGHMgeVKQDNVAEVIAGARF 303
Cdd:pfam00651  12 DVTLVVGDKEFRAHKAVLAACSPYFKAlfsgqesESSVSEITLDDVSPEDFEALLEFMYTGKL--ISEENVDDLLAAADK 89

                          90
                  ....*....|....*...
gi 611980830  304 LQMPCALQCATDAMRAQL 321
Cdd:pfam00651  90 LQIPSLVDKCEEFLIKSL 107
PHA03098 PHA03098
kelch-like protein; Provisional
 232-603 1.29e-17

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 86.75  E-value: 1.29e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 232 LVIEVAGHRIQAHKSVLAAKSDYFRARSSREILRVK---GVSYSALRLLVDYLYTGHMgEVKQDNVAEVIAGARFLQMPC 308
Cdd:PHA03098  14 IIIVNGGGIIKVHKIILSSSSEYFKKMFKNNFKENEinlNIDYDSFNEVIKYIYTGKI-NITSNNVKDILSIANYLIIDF 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 309 ALQCATDAMRAQLTLGNCYQVLSLAKQQRLSELREAAYRFMSDHYLQVLREPsIYGRLTGSERDLILQRRM--------- 379
Cdd:PHA03098  93 LINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDP-DFIYLSKNELIKILSDDKlnvssedvv 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 380 ----------EAGRSCLLVAEINDVF------------------------------ERVGSRPQS--------RESSRPQ 411
Cdd:PHA03098 172 leiiikwltsKKNNKYKDICLILKVLritflseegikklkrwklrikkkkivfnkrCIKIIYSKKynlnkilpRSSTFGS 251

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 412 SPSASVLSPGEQPPTPPPALASSE----------------------------EEGSHSDSVIYYYQEADKEWKVLTRLpe 463
Cdd:PHA03098 252 IIYIHITMSIFTYNYITNYSPLSEintiidihyvycfgsvvlnnviyfiggmNKNNLSVNSVVSYDTKTKSWNKVPEL-- 329

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 464 GANAKGCAMCILYNYLFLAGGILQGGPegrprLSDkVFCYNPVTDTWTTVRSLSQPRSQLKLLALDGYLYAVGG-----E 538
Cdd:PHA03098 330 IYPRKNPGVTVFNNRIYVIGGIYNSIS-----LNT-VESWKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGGiskndE 403

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 611980830 539 CLFSVERYDPRTDRWSAVAPLP---KGGFAVAHeattcNGEIYVSGG-------SLFYRLLKYDPRRDEWQECPC 603
Cdd:PHA03098 404 LLKTVECFSLNTNKWSKGSPLPishYGGCAIYH-----DGKIYVIGGisyidniKVYNIVESYNPVTNKWTELSS 473
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 231-321 2.97e-17

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 77.35  E-value: 2.97e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830   231 DLVIEVAGHRIQAHKSVLAAKSDYFRAR-------SSREILRVKGVSYSALRLLVDYLYTGHMgEVKQDNVAEVIAGARF 303
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALfssdfkeSDKSEIYLDDVSPEDFRALLNFLYTGKL-DLPEENVEELLELADY 79

                           90
                   ....*....|....*...
gi 611980830   304 LQMPCALQCATDAMRAQL 321
Cdd:smart00225  80 LQIPGLVELCEEFLLKLL 97
PHA03098 PHA03098
kelch-like protein; Provisional
 448-561 7.09e-09

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 59.01  E-value: 7.09e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 448 YQEADKEWKVLTRLPEgANAKGCAmcILYN-YLFLAGGILQggpEGRPRLSDKVFCYNPVTDTWTTVRSLSQPRSQLKLL 526
Cdd:PHA03098 411 FSLNTNKWSKGSPLPI-SHYGGCA--IYHDgKIYVIGGISY---IDNIKVYNIVESYNPVTNKWTELSSLNFPRINASLC 484

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 611980830 527 ALDGYLYAVGGECLFS----VERYDPRTDRWSAVAPLPK 561
Cdd:PHA03098 485 IFNNKIYVVGGDKYEYyineIEVYDDKTNTWTLFCKFPK 523
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 519-560 1.13e-08

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 51.46  E-value: 1.13e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 611980830  519 PRSQLKLLALDGYLYAVGG----ECLFSVERYDPRTDRWSAVAPLP 560
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGfdgnQSLNSVEVYDPETNTWSKLPSMP 46
Kelch smart00612
Kelch domain;
532-567 1.08e-07

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 48.71  E-value: 1.08e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 611980830   532 LYAVGG----ECLFSVERYDPRTDRWSAVAPLPKG--GFAVA 567
Cdd:smart00612   2 IYVVGGfdggQRLKSVEVYDPETNKWTPLPSMPTPrsGHGVA 43
 
Name Accession Description Interval E-value
BTB_POZ_KBTBD11 cd18275
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 228-330 2.19e-58

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11 is also called chronic myelogenous leukemia-associated protein (CMLAP) or Kelch domain-containing protein 7B, or KLHDC7C. It is a BTB-Kelch family protein whose function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349584 [Multi-domain]  Cd Length: 104  Bit Score: 193.09  E-value: 2.19e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 228 EEPDLVIEVAGHRIQAHKSVLAAKSDYFRARSSREILRVKGVSYSALRLLVDYLYTGHMGeVKQDNVAEVIAGARFLQMP 307
Cdd:cd18275    3 GEPDLVIEVSGQRIRAHKSVLAAKSDYFRARLSRDILKVKGLSYATLRLLVDYVYSGRMA-VSKDNVVEVVAGARFLQMP 81

                         90       100
                 ....*....|....*....|...
gi 611980830 308 CALQCATDAMRAQLTLGNCYQVL 330
Cdd:cd18275   82 CAAQCAVDAVRAQLCLGNCYEVL 104
BACK_KBTBD11_CMLAP cd18484
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 321-397 3.40e-41

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11, also termed chronic myelogenous leukemia-associated protein (CMLAP), or Kelch domain-containing protein 7B, or KLHDC7C, is a BTB-Kelch family protein. Its function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk; KBTBD11 may function as a tumor suppressor. KBTBD11 hypomethylation may also be a potential target for differentiating between the mostly fatal TCF3-HLF and curable TCF3-PBX1 pediatric acute lymphoblastic leukemia subtypes.


Pssm-ID: 350559  Cd Length: 77  Bit Score: 144.83  E-value: 3.40e-41
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 611980830 321 LTLGNCYQVLSLAKQQRLSELREAAYRFMSDHYLQVLREPSIYGRLTGSERDLILQRRMEAGRSCLLVAEINDVFER 397
Cdd:cd18484    1 LDLGNCYEVLTLAKKQRLNELREAAYKFMSDNYLQVLREPAVYGRLSGAERELILRRRLEAGRACLVVAELNDVFER 77
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
454-602 2.54e-24

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 103.31  E-value: 2.54e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 454 EWKVLTRLPEG-ANAkgcAMCILYNYLFLAGGILQGGPegrprlSDKVFCYNPVTDTWTTVRSLS-QPRSQLKLLALDGY 531
Cdd:COG3055    2 TWSSLPDLPTPrSEA---AAALLDGKVYVAGGLSGGSA------SNSFEVYDPATNTWSELAPLPgPPRHHAAAVAQDGK 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 532 LYAVGG--------ECLFSVERYDPRTDRWSAVAPLPKGgfAVAHEATTCNGEIYVSGG----SLFYRLLKYDPRRDEWQ 599
Cdd:COG3055   73 LYVFGGftganpssTPLNDVYVYDPATNTWTKLAPMPTP--RGGATALLLDGKIYVVGGwddgGNVAWVEVYDPATGTWT 150


                 ...
gi 611980830 600 ECP 602
Cdd:COG3055  151 QLA 153
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
438-621 4.01e-24

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 102.93  E-value: 4.01e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 438 GSHSDSViYYYQEADKEWKVLTRLPEGANAKgcAMCILYN-YLFLAGGIlqGGPEGRPRLSDKVFCYNPVTDTWTTVRSL 516
Cdd:COG3055   34 GSASNSF-EVYDPATNTWSELAPLPGPPRHH--AAAVAQDgKLYVFGGF--TGANPSSTPLNDVYVYDPATNTWTKLAPM 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 517 SQPRSQLKLLALDGYLYAVGGE----CLFSVERYDPRTDRWSAVAPLPK------------------GGFAV-------- 566
Cdd:COG3055  109 PTPRGGATALLLDGKIYVVGGWddggNVAWVEVYDPATGTWTQLAPLPTprdhlaaavlpdgkilviGGRNGsgfsntwt 188

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 611980830 567 ----------AHEATTCNGEIYVSGGSLFYR--LLKYDPRRDEWQECPCSSSRKRSADMVTLKGFIY 621
Cdd:COG3055  189 tlaplptaraGHAAAVLGGKILVFGGESGFSdeVEAYDPATNTWTALGELPTPRHGHAAVLTDGKVY 255
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 231-304 2.22e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 82.99  E-value: 2.22e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 231 DLVIEVAGHRIQAHKSVLAAKSDYFRAR-------SSREILRVKGVSYSALRLLVDYLYTGHMgEVKQDNVAEVIAGARF 303
Cdd:cd18186    3 DVTLVVGGREFPAHRAVLAARSPYFRAMfssgmkeSSSSEIELDDVSPEAFEALLDYIYTGEL-ELSEENVEELLAAADK 81


                 .
gi 611980830 304 L 304
Cdd:cd18186   82 L 82
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 231-321 5.32e-18

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 79.99  E-value: 5.32e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830  231 DLVIEVAGHRIQAHKSVLAAKSDYFRA-------RSSREILRVKGVSYSALRLLVDYLYTGHMgeVKQDNVAEVIAGARF 303
Cdd:pfam00651  12 DVTLVVGDKEFRAHKAVLAACSPYFKAlfsgqesESSVSEITLDDVSPEDFEALLEFMYTGKL--ISEENVDDLLAAADK 89

                          90
                  ....*....|....*...
gi 611980830  304 LQMPCALQCATDAMRAQL 321
Cdd:pfam00651  90 LQIPSLVDKCEEFLIKSL 107
PHA03098 PHA03098
kelch-like protein; Provisional
 232-603 1.29e-17

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 86.75  E-value: 1.29e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 232 LVIEVAGHRIQAHKSVLAAKSDYFRARSSREILRVK---GVSYSALRLLVDYLYTGHMgEVKQDNVAEVIAGARFLQMPC 308
Cdd:PHA03098  14 IIIVNGGGIIKVHKIILSSSSEYFKKMFKNNFKENEinlNIDYDSFNEVIKYIYTGKI-NITSNNVKDILSIANYLIIDF 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 309 ALQCATDAMRAQLTLGNCYQVLSLAKQQRLSELREAAYRFMSDHYLQVLREPsIYGRLTGSERDLILQRRM--------- 379
Cdd:PHA03098  93 LINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDP-DFIYLSKNELIKILSDDKlnvssedvv 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 380 ----------EAGRSCLLVAEINDVF------------------------------ERVGSRPQS--------RESSRPQ 411
Cdd:PHA03098 172 leiiikwltsKKNNKYKDICLILKVLritflseegikklkrwklrikkkkivfnkrCIKIIYSKKynlnkilpRSSTFGS 251

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 412 SPSASVLSPGEQPPTPPPALASSE----------------------------EEGSHSDSVIYYYQEADKEWKVLTRLpe 463
Cdd:PHA03098 252 IIYIHITMSIFTYNYITNYSPLSEintiidihyvycfgsvvlnnviyfiggmNKNNLSVNSVVSYDTKTKSWNKVPEL-- 329

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 464 GANAKGCAMCILYNYLFLAGGILQGGPegrprLSDkVFCYNPVTDTWTTVRSLSQPRSQLKLLALDGYLYAVGG-----E 538
Cdd:PHA03098 330 IYPRKNPGVTVFNNRIYVIGGIYNSIS-----LNT-VESWKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGGiskndE 403

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 611980830 539 CLFSVERYDPRTDRWSAVAPLP---KGGFAVAHeattcNGEIYVSGG-------SLFYRLLKYDPRRDEWQECPC 603
Cdd:PHA03098 404 LLKTVECFSLNTNKWSKGSPLPishYGGCAIYH-----DGKIYVIGGisyidniKVYNIVESYNPVTNKWTELSS 473
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 231-321 2.97e-17

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 77.35  E-value: 2.97e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830   231 DLVIEVAGHRIQAHKSVLAAKSDYFRAR-------SSREILRVKGVSYSALRLLVDYLYTGHMgEVKQDNVAEVIAGARF 303
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALfssdfkeSDKSEIYLDDVSPEDFRALLNFLYTGKL-DLPEENVEELLELADY 79

                           90
                   ....*....|....*...
gi 611980830   304 LQMPCALQCATDAMRAQL 321
Cdd:smart00225  80 LQIPGLVELCEEFLLKLL 97
BTB_POZ_KLHL26 cd18255
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 225-326 5.97e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349564 [Multi-domain]  Cd Length: 121  Bit Score: 77.43  E-value: 5.97e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 225 ALREEP---DLVIEVAGHRIQAHKSVLAAKSDYFRA-------RSSREILRVKGVSYSALRLLVDYLYTGHMGeVKQDNV 294
Cdd:cd18255   11 ALRAKGqllDVTLIADGQRFQAHKVVLASCSDYFRAmftggmrESSQDEIELKGVSAKGLKHILDFAYTSELT-LDLDCI 89

                         90       100       110
                 ....*....|....*....|....*....|..
gi 611980830 295 AEVIAGARFLQMPCALQCATDAMRAQLTLGNC 326
Cdd:cd18255   90 QDVLGAAVHLQMLPVVELCEEFLKSAMSVENC 121
BTB_POZ_NS1BP cd18306
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 231-326 8.07e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349615 [Multi-domain]  Cd Length: 124  Bit Score: 77.30  E-value: 8.07e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 231 DLVIEVAGHRIQAHKSVLAAKS----DYFRARSSREILR---VKGVSYSALRLLVDYLYTGHMgEVKQDNVAEVIAGARF 303
Cdd:cd18306   20 DVILQVGGHEIPAHRAVLACASpylfELFSSDSDGESILtvkLDGLDPDAVEVLVNYAYTSRL-EVPADLVKSVYSAAKK 98

                         90       100
                 ....*....|....*....|...
gi 611980830 304 LQMPCALQCATDAMRAQLTLGNC 326
Cdd:cd18306   99 LKMDRVKKACGDFLLEKLTPQNC 121
BTB_POZ_KLHL1-like cd18234
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 233-326 3.23e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349543 [Multi-domain]  Cd Length: 105  Bit Score: 74.71  E-value: 3.23e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 233 VIEVAGH-RIQAHKSVLAAKSDYFRA-------RSSREILRVKGVSYSALRLLVDYLYTGHMgEVKQDNVAEVIAGARFL 304
Cdd:cd18234    4 VILIAGDrRIPAHRLVLSAVSDYFAAmftndvrEATEEEIKLKDVDPDALWTLVQYCYTGRL-ELKEDNVESLLATACLL 82

                         90       100
                 ....*....|....*....|..
gi 611980830 305 QMPCALQCATDAMRAQLTLGNC 326
Cdd:cd18234   83 QLSEVVEACCGFLMKQLHPSNC 104
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
445-583 3.42e-15

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 76.73  E-value: 3.42e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 445 IYYYQEADKEWKVLTRLPEGANAKGCAmcILYNYLFLAGGILQGGPEGrprlsdKVFCYNPVTDTWTTVRSLSQPRSQL- 523
Cdd:COG3055   92 VYVYDPATNTWTKLAPMPTPRGGATAL--LLDGKIYVVGGWDDGGNVA------WVEVYDPATGTWTQLAPLPTPRDHLa 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 524 -------KLL------------------------------ALDGYLYAVGGECLFS--VERYDPRTDRWSAVAPLPKGGF 564
Cdd:COG3055  164 aavlpdgKILviggrngsgfsntwttlaplptaraghaaaVLGGKILVFGGESGFSdeVEAYDPATNTWTALGELPTPRH 243

                        170
                 ....*....|....*....
gi 611980830 565 AVAheATTCNGEIYVSGGS 583
Cdd:COG3055  244 GHA--AVLTDGKVYVIGGE 260
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 231-326 8.04e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 71.67  E-value: 8.04e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 231 DLVIEVAGHRIQAHKSVLAAKSDYFRA-------RSSREILRVKGVSYSALRLLVDYLYTGHMgEVKQDNVAEVIAGARF 303
Cdd:cd18256   22 DVQLQVGMELFSVHRLVLAASSPYFAAlfaggmsESSKDVVQIHGVEPDIFHILLDFIYTGVV-EVTVSNVQELLVAADM 100

                         90       100
                 ....*....|....*....|...
gi 611980830 304 LQMPCALQCATDAMRAQLTLGNC 326
Cdd:cd18256  101 LQLTEVVEICCEFLKGQLHPSNC 123
BTB_POZ_KLHL8 cd18238
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 231-326 7.46e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349547 [Multi-domain]  Cd Length: 120  Bit Score: 68.47  E-value: 7.46e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 231 DLVIEVAGHRIQAHKSVLAAKSDYFRA-------RSSREILRVKGVSYSALRLLVDYLYTGHMgEVKQDNVAEVIAGARF 303
Cdd:cd18238   17 DVTLKVGEKSIHCHRLVLACVSPYFRAmftsemaESKQDSITIKDIDEEAVELLVDFAYTGKL-TLTVDNVQSLLYAASL 95

                         90       100
                 ....*....|....*....|...
gi 611980830 304 LQMPCALQCATDAMRAQLTLGNC 326
Cdd:cd18238   96 LQVEEVAKACCEFMKDHLHPSNC 118
BTB_POZ_BTBD18 cd18293
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 231-307 8.08e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349602 [Multi-domain]  Cd Length: 120  Bit Score: 68.66  E-value: 8.08e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 231 DLVIEVAGHRIQAHKSVLAAKSDYFRARSSRE--------ILRVKGVSYSALRLLVDYLYTGHMgEVKQDNVAEVIAGAR 302
Cdd:cd18293   17 DVLLQAEGESVPAHCCVLSACSPYLTERLSSEpppagqkvVLELQGLKAHTLLKLVDFLYTSEL-EVSSEEAQDVLAAAR 95


                 ....*
gi 611980830 303 FLQMP 307
Cdd:cd18293   96 RLQIS 100
BTB_POZ_KLHL22 cd18251
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 231-315 4.22e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349560 [Multi-domain]  Cd Length: 125  Bit Score: 66.77  E-value: 4.22e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 231 DLVIEVAGHRIQAHKSVLAAKSDYFR---ARSSREI----LRVKGVSYSALRLLVDYLYTGHMgEVKQDNVAEVIAGARF 303
Cdd:cd18251   25 DVVLVVEGKPIEAHRILLAASCDYFRgmfAGGLREMqqteVLIHGVSYNAMCKILDFIYTSEL-ELSLDNVQETLTAACQ 103

                         90
                 ....*....|..
gi 611980830 304 LQMPCALQCATD 315
Cdd:cd18251  104 LQIPEVIGFCCD 115
BTB_POZ_KLHL18 cd18247
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 231-307 4.53e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349556 [Multi-domain]  Cd Length: 116  Bit Score: 66.15  E-value: 4.53e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 231 DLVIEVAGHRIQAHKSVLAAKSDYFRA--------RSSREILrVKGVSYSALRLLVDYLYTGHMgEVKQDNVAEVIAGAR 302
Cdd:cd18247   21 DVTLKVGDQKFSAHRIVLAATIPYFHAmfthdmveSKQDEIT-MQGIEPSALEALINFAYSGRI-AIDTSNVQSLLVGAS 98


                 ....*
gi 611980830 303 FLQMP 307
Cdd:cd18247   99 FLQLQ 103
BTB_POZ_KLHL21 cd18250
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 225-326 7.33e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349559 [Multi-domain]  Cd Length: 124  Bit Score: 65.95  E-value: 7.33e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 225 ALREEP---DLVIEVAGHRIQAHKSVLAAKSDYFRA------RSSR-EILRVKGVSYSALRLLVDYLYTGHMGeVKQDNV 294
Cdd:cd18250   14 ELRAERkffDVTLCAGGREFPCHRTVLAAASSYFRAmfagelRESRaDRVVLHGVSAEILGLLLDFSYTGRVT-VTQDNV 92

                         90       100       110
                 ....*....|....*....|....*....|..
gi 611980830 295 AEVIAGARFLQMPCALQCATDAMRAQLTLGNC 326
Cdd:cd18250   93 EALLRAADLFQFPSVKEACCAYLQQRLDVSNC 124
BTB_POZ_KLHL28_BTBD5 cd18257
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 231-321 1.80e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349566 [Multi-domain]  Cd Length: 118  Bit Score: 64.48  E-value: 1.80e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 231 DLVIEVAGHRIQAHKSVLAAKSDYFRA-------RSSREILRVKGVSYSALRLLVDYLYTGHMGeVKQDNVAEVIAGARF 303
Cdd:cd18257   20 DVVLRVGDVKIHAHKVVLASCSPYFKAmftgnlsEKENSEVEFQCIDETALQAIVEYAYTGTVF-ISQATVESLLPAANL 98

                         90
                 ....*....|....*...
gi 611980830 304 LQMPCALQCATDAMRAQL 321
Cdd:cd18257   99 LQIKLVLKECCDFLESQL 116
BTB_POZ_KLHL4 cd18336
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 233-326 2.04e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349645 [Multi-domain]  Cd Length: 126  Bit Score: 64.68  E-value: 2.04e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 233 VIEVAG-HRIQAHKSVLAAKSDYFRA-------RSSREILRVKGVSYSALRLLVDYLYTGHMgEVKQDNVAEVIAGARFL 304
Cdd:cd18336   22 VLLIAGnLKIPAHRLVLSAVSDYFAAmftndvrEAKQEEIKMEGVDPDALKALVHYAYTGVL-ELKEDTIESLLAAACLL 100

                         90       100
                 ....*....|....*....|..
gi 611980830 305 QMPCALQCATDAMRAQLTLGNC 326
Cdd:cd18336  101 QLSQVIDVCCNFLMKQLHPSNC 122
BTB_POZ_BAB-like cd18315
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 231-305 2.21e-12

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349624 [Multi-domain]  Cd Length: 85  Bit Score: 63.34  E-value: 2.21e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 231 DLVIEVAGHRIQAHKSVLAAKSDYFRA-----RSSRE-ILRVKGVSYSALRLLVDYLYTGHMgEVKQDNVAEVIAGARFL 304
Cdd:cd18315    3 DVTLACEGGSLKAHKLVLAAASPYFAAllketPPDEHpVIILPDVPYSELKALLDFIYTGEV-NVSQEQLESLLKLAELL 81


                 .
gi 611980830 305 Q 305
Cdd:cd18315   82 Q 82
BTB_POZ_KLHL2-like cd18235
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 231-321 4.06e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349544 [Multi-domain]  Cd Length: 121  Bit Score: 63.60  E-value: 4.06e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 231 DLVIEVAGHRIQAHKSVLAAKSDYFRA-------RSSREILRVKGVSYSALRLLVDYLYTGHMgEVKQDNVAEVIAGARF 303
Cdd:cd18235   23 DVILVADGVEIPAHRVVLASCSPYFHAmftgdlsESRANRVTLQDVDGKALLLLIDYVYTAEI-QVTEENVQVLLPAANL 101

                         90
                 ....*....|....*...
gi 611980830 304 LQMPCALQCATDAMRAQL 321
Cdd:cd18235  102 LQLTDVRDACCDFLQSQL 119
BTB_POZ_KLHL12_C3IP1_DKIR cd18242
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 225-326 1.20e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349551 [Multi-domain]  Cd Length: 124  Bit Score: 62.46  E-value: 1.20e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 225 ALREEP---DLVIEVAGHRIQAHKSVLAAKSDYFRA-------RSSREILRVKGVSYSALRLLVDYLYTGHMgEVKQDNV 294
Cdd:cd18242   14 SLRKSNtlcDVTLRVEGKEFPAHRIVLAACSDYFCAmftsemsEKGKSEVELQGLTASTMEILLDFVYTETV-HVTVENV 92

                         90       100       110
                 ....*....|....*....|....*....|..
gi 611980830 295 AEVIAGARFLQMPCALQCATDAMRAQLTLGNC 326
Cdd:cd18242   93 QELLPAACLLQLKGVKQACCEFLESQLDPSNC 124
BTB_POZ_KLHL7 cd18237
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 231-326 2.89e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349546 [Multi-domain]  Cd Length: 126  Bit Score: 61.35  E-value: 2.89e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 231 DLVIEVAGHRIQAHKSVLAAKSDYFR---------ARSSReiLRVKGVSYSALRLLVDYLYTGHMgEVKQDNVAEVIAGA 301
Cdd:cd18237   23 DVILIVEGREIKAHRVVLAAASHFFHlmftsnmteSKSSE--VELKDAEPDIIELLVEFAYTARI-SVNSNNVQSLLDAA 99

                         90       100
                 ....*....|....*....|....*
gi 611980830 302 RFLQMPCALQCATDAMRAQLTLGNC 326
Cdd:cd18237  100 NQYQIEPVKKMCVDFLKEQLDASNC 124
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 231-301 3.44e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 61.10  E-value: 3.44e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 231 DLVIEVAGHRIQAHKSVLAAKSDYFRA-------RSSREILRVKGVSYSALRLLVDYLYTGHM--GEVKQDNVAEVIAGA 301
Cdd:cd18287   24 DVTFVVEEKRFPAHRVILAARSEYFRAllyggmrESQQSEIELKDTNAEAFKALLKYIYTGRLtlTDLKEDVLLDVLGLA 103
BTB_POZ_KLHL10 cd18240
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 231-326 9.64e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349549 [Multi-domain]  Cd Length: 120  Bit Score: 59.65  E-value: 9.64e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 231 DLVIEVAGHRIQAHKSVLAAKSDYFRA-------RSSREILRVKGVSYSALRLLVDYLYTGHMgEVKQDNVAEVIAGA-R 302
Cdd:cd18240   19 DVVIRVNGVEFPAHRNILCACSPYFRAlftngwnETEKKVYKIPGVSPEMMELIIEYAYTRTV-PITAENVEELLPAAdQ 97

                         90       100
                 ....*....|....*....|....
gi 611980830 303 FLQMPCALQCAtDAMRAQLTLGNC 326
Cdd:cd18240   98 FNIMGIVKACC-DFLEDQLCPENC 120
BTB_POZ_KLHL38 cd18268
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 225-326 1.13e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349577 [Multi-domain]  Cd Length: 129  Bit Score: 59.80  E-value: 1.13e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 225 ALREE---PDLVIEVAGHRIQAHKSVLAAKSDYFRA-------RSSREILRVKGVSYSALRLLVDYLYTGHMgEVKQDNV 294
Cdd:cd18268   16 SLRQErilTDVILCTGDKEIPCHRNVLASSSPYFRAmfcnnfrESSQAKVDLKGIDSDVLDQIVDYVYTGEI-LITRDNV 94

                         90       100       110
                 ....*....|....*....|....*....|..
gi 611980830 295 AEVIAGARFLQMPCALQCATDAMRAQLTLGNC 326
Cdd:cd18268   95 LPLMEAASMLQYPKLFEACSLYLQDQLTPENC 126
BTB1_POZ_RhoBTB cd18299
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 238-307 6.29e-10

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349608 [Multi-domain]  Cd Length: 103  Bit Score: 56.84  E-value: 6.29e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 611980830 238 GHRIQAHKSVLAAKSDYFRA--RSSREILRVKGVSYSALRLLVDYLYTGHMGEvKQDNVAEVIAGARFLQMP 307
Cdd:cd18299   22 GVRIFAHRIVLAAASSVFADlfLMMTVVTLDSDITPEAFRRVLEFLYTGVLDE-NEDDLKELKDAAELLELF 92
BTB_POZ_KBTBD3_BKLHD3 cd18271
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 231-329 1.22e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349580 [Multi-domain]  Cd Length: 130  Bit Score: 56.76  E-value: 1.22e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 231 DLVIEVAGHRIQAHKSVLAAKSDYFRAR---SSREilRVKG------VSYSALRLLVDYLYTGHMgEVKQDNVAEVIAGA 301
Cdd:cd18271   26 DFNIIVKDETIPCHRCVLAACSDFFRAMfevNMKE--RDDGsvtisnLSPKAVKAFLDYAYTGKA-EITDDNVEMFFQMS 102

                         90       100
                 ....*....|....*....|....*...
gi 611980830 302 RFLQMPCALQCATDAMRAQLTLGNCYQV 329
Cdd:cd18271  103 SFLQVSLLSKACSDFLIKSIDLTNCLQL 130
BTB_POZ_ZBTB35_ZNF131 cd18221
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 231-311 1.93e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349530 [Multi-domain]  Cd Length: 113  Bit Score: 55.78  E-value: 1.93e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 231 DLVIEVAGHRIQAHKSVLAAKSDYF----RARSSREILRVKGVSYSALRLLVDYLYTGHMGEVKQDNVAEVIAGARFLQM 306
Cdd:cd18221   20 DITLIVDGHQFKAHKAVLAACSQFFykffQDFTQEPLVEIEGVSNMAFRHLIEFTYTAKLMVQGEEEANDVWKAAEYLQM 99


                 ....*
gi 611980830 307 PCALQ 311
Cdd:cd18221  100 QEAIK 104
BTB2_POZ_BTBD8 cd18286
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 228-301 2.22e-09

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349595 [Multi-domain]  Cd Length: 121  Bit Score: 55.73  E-value: 2.22e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 228 EEPDLVIEVAGHRIQAHKSVLAAKSDYFRA-------RSSREILRVKGVSYSALRLLVDYLYTGHMGEVKQDNVAEVIAG 300
Cdd:cd18286   16 EDSDITIKVDGKTFKAHRCILCARSSYFAAmlsgswaESNSSEITLTGVSHAAVSFVLLFIYGGVLDLPDDVNLGELLSL 95


                 .
gi 611980830 301 A 301
Cdd:cd18286   96 A 96
BTB_POZ_KBTBD6_7 cd18273
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 231-330 3.69e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349582 [Multi-domain]  Cd Length: 142  Bit Score: 55.99  E-value: 3.69e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 231 DLVIEVA--------GHRIQAHKSVLAAKSDYFRA-------RSSREILRVKGVSYSALRLLVDYLYTGHMgEVKQDNVA 295
Cdd:cd18273   28 DVTIEVNgpgsgpgsGRLFPCNRNVLAAASPYFKSmftgglyESKQETVTIHDVDSESMALIIDYCYTGRV-TLSEANVQ 106

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 611980830 296 EVIAGARFLQMPCALQCATDAMRAQLTLGNCYQVL 330
Cdd:cd18273  107 RLYAAANMLQLEYVREACASFLARRLDLSNCVGIL 141
BTB_POZ_KLHL15 cd18244
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 214-330 4.02e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349553 [Multi-domain]  Cd Length: 137  Bit Score: 55.73  E-value: 4.02e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 214 SIDQSNVPAG-GALREEP---DLVIEVAGHRIQAHKSVLAAKSDYFRARSSREI-------LRVKGVSYSALRLLVDYLY 282
Cdd:cd18244   11 SIHDTSVSAGfRALYEEGlllDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMrerdqdkIHLKGLTATGFSHVLQFMY 90

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 611980830 283 TGHMgEVKQDNVAEVIAGARFLQMPCALQCATDAMRAQLTLGNCYQVL 330
Cdd:cd18244   91 YGTI-ELSMLTVHEILQAAMYVQLTEVVKFCCSFLLAKICLDNCAEIM 137
BTB_POZ_KLHL34 cd18264
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 225-326 4.03e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349573 [Multi-domain]  Cd Length: 136  Bit Score: 55.57  E-value: 4.03e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 225 ALREEP---DLVIEVAGHRIQAHKSVLAAKSDYFRA------RSSRE-ILRVKGVSYSALRLLVDYLYTGHMgEVKQDNV 294
Cdd:cd18264   21 SLRAEGflcDVVLEAEGNEFPAHRSLLACSSDYFRAlfkdytQESKArVIHLPVVSAAGLQRVLDFIYTSWL-SLSLDTL 99

                         90       100       110
                 ....*....|....*....|....*....|..
gi 611980830 295 AEVIAGARFLQMPCALQCATDAMRAQLTLGNC 326
Cdd:cd18264  100 EDTLEAASYLQVTEAIGLCSQYLINNLAPENC 131
BTB2_POZ_RhoBTB cd18300
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 231-307 4.49e-09

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349609 [Multi-domain]  Cd Length: 108  Bit Score: 54.55  E-value: 4.49e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 231 DLVIEVAGHRIQAHKSVLAAKSDYFRA--------RSSREIlRVKGVSYSALRLLVDYLYTGHMGEVKQDNVAEVIAGAR 302
Cdd:cd18300   11 DVTFIVEDGTIPAHKALLVARCDVMAAmfggnfreSSAKEV-ELPGVSKETFLALLEYLYTDQAPILEDGDCVGLIVLAN 89


                 ....*
gi 611980830 303 FLQMP 307
Cdd:cd18300   90 RLCLP 94
BTB_POZ_KLHL24_KRIP6 cd18253
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 231-326 6.43e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349562 [Multi-domain]  Cd Length: 121  Bit Score: 54.46  E-value: 6.43e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 231 DLVIEVAGHRIQAHKSVLAAKSDYFRA------RSSREIL-RVKGVSYSALRLLVDYLYTGHMgEVKQDNVAEVIAGARF 303
Cdd:cd18253   20 DVIICVEGREFPCHRAILSACSSYFRAmfcndhRESREMLvEINGILAEAMDCFLQYVYTGKV-KITTENVQYLFETSSL 98

                         90       100
                 ....*....|....*....|...
gi 611980830 304 LQMPCALQCATDAMRAQLTLGNC 326
Cdd:cd18253   99 FQISPLRDACAKFLEEQLDPCNC 121
PHA03098 PHA03098
kelch-like protein; Provisional
 448-561 7.09e-09

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 59.01  E-value: 7.09e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 448 YQEADKEWKVLTRLPEgANAKGCAmcILYN-YLFLAGGILQggpEGRPRLSDKVFCYNPVTDTWTTVRSLSQPRSQLKLL 526
Cdd:PHA03098 411 FSLNTNKWSKGSPLPI-SHYGGCA--IYHDgKIYVIGGISY---IDNIKVYNIVESYNPVTNKWTELSSLNFPRINASLC 484

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 611980830 527 ALDGYLYAVGGECLFS----VERYDPRTDRWSAVAPLPK 561
Cdd:PHA03098 485 IFNNKIYVVGGDKYEYyineIEVYDDKTNTWTLFCKFPK 523
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 519-560 1.13e-08

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 51.46  E-value: 1.13e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 611980830  519 PRSQLKLLALDGYLYAVGG----ECLFSVERYDPRTDRWSAVAPLP 560
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGfdgnQSLNSVEVYDPETNTWSKLPSMP 46
BTB_POZ_ZBTB7A cd18326
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 231-315 1.39e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349635 [Multi-domain]  Cd Length: 120  Bit Score: 53.40  E-value: 1.39e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 231 DLVIEVAGHRIQAHKSVLAAKSDYFR-------ARSSREILRVKGVSYSALRLLVDYLYTGHMgEVKQDNVAEVIAGARF 303
Cdd:cd18326   27 DVVILVEGREFPTHRSVLAACSQYFKklftsgaVVDQQNVYEIDFVSAEALTALLDFAYTATL-TVSTSNVGDILSAARL 105

                         90
                 ....*....|..
gi 611980830 304 LQMPCALQCATD 315
Cdd:cd18326  106 LEIPAVSHVCAD 117
BTB_POZ_KLHL1 cd18335
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 231-326 1.68e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton the brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349644 [Multi-domain]  Cd Length: 126  Bit Score: 53.51  E-value: 1.68e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 231 DLVIEVAGHRIQAHKSVLAAKSDYFRA-------RSSREILRVKGVSYSALRLLVDYLYTGHMgEVKQDNVAEVIAGARF 303
Cdd:cd18335   21 DVILIAGNRKIPAHRLVLSAVSDYFAAmftsdvcEAKQEEIKMEGIDPNALWDLVQFAYTGCL-ELKEDTIENLLAAACL 99

                         90       100
                 ....*....|....*....|...
gi 611980830 304 LQMPCALQCATDAMRAQLTLGNC 326
Cdd:cd18335  100 LQLSQVVEVCCHFLMKLLHPSNC 122
BTB_POZ_KBTBD8 cd18274
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 231-329 1.92e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349583 [Multi-domain]  Cd Length: 129  Bit Score: 53.45  E-value: 1.92e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 231 DLVIEV-AGHRIQAHKSVLAAKSDYFRA-------RSSREILRVKGVSYSALRLLVDYLYTGHMgEVKQDNVAEVIAGAR 302
Cdd:cd18274   24 DIVVEVdHGKTFSCHRNVLAAISPYFRSmftsgltESTQKEVRIVGVEAESMHLVLDYAYTSRV-TLTEANVQALFTAAS 102

                         90       100
                 ....*....|....*....|....*...
gi 611980830 303 FLQMPCAL-QCAtDAMRAQLTLGNCYQV 329
Cdd:cd18274  103 IFQIPSLQdQCA-QFMISRLDPQNSIGV 129
BTB_POZ_KLHL3 cd18339
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 231-321 2.32e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349648 [Multi-domain]  Cd Length: 121  Bit Score: 52.80  E-value: 2.32e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 231 DLVIEVAGHRIQAHKSVLAAKSDYFRA-------RSSREILRVKGVSYSALRLLVDYLYTGHMgEVKQDNVAEVIAGARF 303
Cdd:cd18339   23 DVTIVAEDVEIEAHRVVLAACSPYFCAmftgdmsESKAKKIEIKDVDGQTLSKLIDYIYTAEI-EVTEENVQVLLPAASL 101

                         90
                 ....*....|....*...
gi 611980830 304 LQMPCALQCATDAMRAQL 321
Cdd:cd18339  102 LQLMDVRQNCCDFLQSQL 119
BTB_POZ_KLHL5 cd18337
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 231-326 2.75e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It is abundantly expressed in the ovary, adrenal gland, and thymus. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349646 [Multi-domain]  Cd Length: 130  Bit Score: 53.14  E-value: 2.75e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 231 DLVIEVAGHRIQAHKSVLAAKSDYFRA-------RSSREILRVKGVSYSALRLLVDYLYTGHMgEVKQDNVAEVIAGARF 303
Cdd:cd18337   25 DVVLVAGDRRIPAHRLVLSSVSDYFAAmftndvrEAKQEEIKMEGVEPNALWALVQYAYTGRL-ELKEDNIECLLSTACL 103

                         90       100
                 ....*....|....*....|...
gi 611980830 304 LQMPCALQCATDAMRAQLTLGNC 326
Cdd:cd18337  104 LQLSQVVEACCKFLMKQLHPSNC 126
BTB_POZ_KLHL20_KLEIP cd18249
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 227-326 3.54e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349558 [Multi-domain]  Cd Length: 128  Bit Score: 52.45  E-value: 3.54e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 227 REEPDLVIEVAGHRIQAHKSVLAAKSDYFRARSSREI-------LRVKGVSYSALRLLVDYLYTGHMgEVKQDNVAEVIA 299
Cdd:cd18249   21 RELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELaesrqteVTIRDIDERAMELLIDFAYTSQI-TVEEGNVQTLLP 99

                         90       100
                 ....*....|....*....|....*..
gi 611980830 300 GARFLQMPCALQCATDAMRAQLTLGNC 326
Cdd:cd18249  100 AACLLQLAEIQEVCCEFLKRQLDPSNC 126
BTB_POZ_ZBTB44 cd18228
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 231-321 4.26e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349537 [Multi-domain]  Cd Length: 126  Bit Score: 52.17  E-value: 4.26e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 231 DLVIEVAGHRIQAHKSVLAAKSDYFRAR--------------SSREILRVKGVSYSALRLLVDYLYTGHMgEVKQDNVAE 296
Cdd:cd18228   21 DVTIRVQDKIFRAHKVVLAACSDFFRSKlvgqasprlvlvspAGKCVLDLHHVTVTGFAPLLEYAYTSTL-SINTENIID 99

                         90       100
                 ....*....|....*....|....*
gi 611980830 297 VIAGARFLQMPCALQCATDAMRAQL 321
Cdd:cd18228  100 VLAAASYMQMFNVANTCSEFMKSSI 124
BTB_POZ_ZBTB41 cd18226
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 231-311 4.32e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 41 (ZBTB41); ZBTB41, also called FRBZ1, may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349535 [Multi-domain]  Cd Length: 114  Bit Score: 52.11  E-value: 4.32e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 231 DLVIEVAGHRIQAHKSVLAAKSDYFRARSSR----EILRVKGVSYSALRLLVDYLYTGHMgEVKQDNVAEVIAGARFLQM 306
Cdd:cd18226   24 DLVITVEGKEFSAHKVVVAVGSSYFHACLSKnpntDAVTLDHVSYSVFQHLLEFLYTSEF-FVYENEIPLVLEAAKFLDI 102


                 ....*
gi 611980830 307 PCALQ 311
Cdd:cd18226  103 IDAVK 107
BTB_POZ_KLHL35 cd18265
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 231-326 4.92e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349574 [Multi-domain]  Cd Length: 128  Bit Score: 52.08  E-value: 4.92e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 231 DLVIEVAGHRIQAHKSVLAAKSDYFRA-------RSSREILRVKGVSYSALRLLVDYLYTGHMgEVKQDNVAEVIAGARF 303
Cdd:cd18265   25 DVVLLVDGKDFPCHRATLSANSAYFRAmfgghlkESRQAVVEIQKVSAAAMEVLLDYMYGGGL-RIQEDNVESVLEASDL 103

                         90       100
                 ....*....|....*....|...
gi 611980830 304 LQMPCALQCATDAMRAQLTLGNC 326
Cdd:cd18265  104 LQVSKLREACVRFLEGQLHPCNC 126
BTB_POZ_KLHL16_gigaxonin cd18245
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 224-306 5.32e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349554 [Multi-domain]  Cd Length: 111  Bit Score: 51.57  E-value: 5.32e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 224 GALREEP---DLVIEVAGHRIQAHKSVLAAKSDYFRAR---------SSREILRVKGVSYSALRLLVDYLYTGHMgEVKQ 291
Cdd:cd18245    6 NSFREEPhlcDATLVVGGEEIPVQKNVLAAASPYFRAKlnynppkddGSTYKIELEGISVEVMEEILDYIYTGQI-KLSE 84

                         90
                 ....*....|....*
gi 611980830 292 DNVAEVIAGARFLQM 306
Cdd:cd18245   85 DNIQDIVQAADLLLM 99
BTB_POZ_ZBTB29_HIC1 cd18333
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 231-307 5.64e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1); Hic-1, also called zinc finger and BTB domain-containing protein 29 (ZBTB29), is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. It may act as a tumor suppressor, and is involved in regulatory loops modulating P53-dependent and E2F1-dependent cell survival, growth control, and stress responses. It also regulates intestinal immunity and homeostasis. Hic-1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349642 [Multi-domain]  Cd Length: 121  Bit Score: 51.83  E-value: 5.64e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 231 DLVIEVAGHRIQAHKSVLAAKSDYFRARSSREIL---RVKGVSYSALRLLVDYLYTGHMGEVKQ---DNVAEVIAGARFL 304
Cdd:cd18333   23 DVIIVVQNALFRAHKNILAASSVYLKSLVVHDNLinlDHEMVSPGIFRLILDYIYTGRLSEGDPgseQNLGAVLAAASYL 102


                 ...
gi 611980830 305 QMP 307
Cdd:cd18333  103 QIP 105
BTB_POZ_ZBTB8B cd18330
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 231-306 7.40e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349639 [Multi-domain]  Cd Length: 113  Bit Score: 51.08  E-value: 7.40e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 231 DLVIEVAGHRIQAHKSVLAAKSDYFRA----------RSSREILRVkgVSYSALRLLVDYLYTGHMgEVKQDNVAEVIAG 300
Cdd:cd18330   20 DCSIIVEGRIFKAHRNILFANSGYFRAllihyiqdsgRHSTASLDI--VTSEAFSIILDFLYSGKL-DLCSENVIEVMSA 96


                 ....*.
gi 611980830 301 ARFLQM 306
Cdd:cd18330   97 ASYLQM 102
BTB_POZ_KLHL14_printor cd18243
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 231-328 8.08e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 14 (KLHL14); KLHL14 is also called protein interactor of Torsin-1A (TOR1A), protein interactor of torsinA, or Printor. It is a novel torsinA-interacting protein that preferentially interacts with ATP-free form of TOR1A and is implicated in dystonia pathogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349552 [Multi-domain]  Cd Length: 130  Bit Score: 51.58  E-value: 8.08e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 231 DLVIEVAGHRIQAHKSVLAAKSDYFRARSSREILRVKGVSYSALRLLVDYLYTGHMgEVKQDNVAEVIAGARFLQMPCAL 310
Cdd:cd18243   34 DVTLTAQGQQFHCHKAVLASCSQYFRSLFSINNLVLQGCSSIGLRLVLEYLYTANV-TLSLDTVEEVLSVSKILHIPQVT 112

                         90
                 ....*....|....*...
gi 611980830 311 QCATDAMRAQLTLGNCYQ 328
Cdd:cd18243  113 KLCVQFLNDQISVQNYKQ 130
BTB1_POZ_ABTB1_BPOZ1 cd18295
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 230-298 1.05e-07

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349604 [Multi-domain]  Cd Length: 119  Bit Score: 51.10  E-value: 1.05e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 611980830 230 PDLVIEVAGHRIQAHKSVLAAKSDYF------RARSSREI-LRVKGVSYSALRLLVDYLYTGHMgEVKQDNVAEVI 298
Cdd:cd18295   20 SDVTFNVHGESFPAHRCILSARSPYFaemfetKWKDKREInLKHPLVNPDAFRALLQYLYTGRL-EIHVDDVEDCK 94
Kelch smart00612
Kelch domain;
532-567 1.08e-07

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 48.71  E-value: 1.08e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 611980830   532 LYAVGG----ECLFSVERYDPRTDRWSAVAPLPKG--GFAVA 567
Cdd:smart00612   2 IYVVGGfdggQRLKSVEVYDPETNKWTPLPSMPTPrsGHGVA 43
BTB_POZ_KLHL2_Mayven cd18338
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 231-321 1.20e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349647 [Multi-domain]  Cd Length: 121  Bit Score: 50.84  E-value: 1.20e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 231 DLVIEVAGHRIQAHKSVLAAKSDYFRARSSREI-------LRVKGVSYSALRLLVDYLYTGHMgEVKQDNVAEVIAGARF 303
Cdd:cd18338   23 DVTIVAEDVEIAAHRVVLAACSPYFHAMFTGEMsesrakrVRIKEVDGWTLKMLIDYVYTAEI-QVTEENVQVLLPAAGL 101

                         90
                 ....*....|....*...
gi 611980830 304 LQMPCALQCATDAMRAQL 321
Cdd:cd18338  102 LQLQDVKKTCCEFLESQL 119
BTB_POZ_ZBTB34 cd18220
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 231-319 1.32e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34); ZBTB34 acts as a transcriptional regulator. It downregulates specificity protein (Sp) transcription factors Sp1, Sp3, and Sp4 in pancreatic cancer cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349529 [Multi-domain]  Cd Length: 120  Bit Score: 50.79  E-value: 1.32e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 231 DLVIEVAGHRIQAHKSVLAAKSDYFRARSSREILrvKGVSYSALR------LLVDYLYTGHMGeVKQDNVAEVIAGARFL 304
Cdd:cd18220   27 DIIVHIQGQPFRAHKAVLAASSPYFRDHSALSTM--SGLSISVIKnpnvfeQLLSFCYTGRMS-LQLKDVVSFLTAASFL 103

                         90
                 ....*....|....*
gi 611980830 305 QMPCALQCATDAMRA 319
Cdd:cd18220  104 QMQCVIDKCTQILES 118
BTB_POZ_ZBTB46 cd18230
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 231-323 1.55e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349539 [Multi-domain]  Cd Length: 125  Bit Score: 50.83  E-value: 1.55e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 231 DLVIEVAGHRIQAHKSVLAAKSDYF--------RARSSREILRVKGVSYSALRLLVDYLYTGHMGeVKQDNVAEVIAGAR 302
Cdd:cd18230   23 DVCIIVEGKIFKAHKNVLLGSSRYFktlycqvqKTSDQATVTHLDIVTAQGFKAIIDFMYSAHLA-LTSKNVIEVMSAAS 101

                         90       100
                 ....*....|....*....|.
gi 611980830 303 FLQMPCALQCATDAMRAQLTL 323
Cdd:cd18230  102 YLQMTDIVQACHNFIKAALDI 122
BTB_POZ_KLHL30 cd18259
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 226-326 1.81e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349568 [Multi-domain]  Cd Length: 137  Bit Score: 50.98  E-value: 1.81e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 226 LREEP---DLVIEVAGHRIQAHKSVLAAKSDYFRARSSREIL-------RVKGVSYSALRLLVDYLYTGHMgEVKQDNVA 295
Cdd:cd18259   26 LRSNPklsDVTLLVGGREFPCHRSVLALCSHYFNAMFTGDFVesisarvEIKDVDPAVMESLIDFAYTGKL-TINQGNVE 104

                         90       100       110
                 ....*....|....*....|....*....|.
gi 611980830 296 EVIAGARFLQMPCALQCATDAMRAQLTLGNC 326
Cdd:cd18259  105 ALIRTSNRLQFPTVRKVCSRYLQQQIDATNC 135
BTB_POZ_KLHL6 cd18236
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 231-307 1.90e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349545 [Multi-domain]  Cd Length: 129  Bit Score: 50.62  E-value: 1.90e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 231 DLVIEVAGHRIQAHKSVLAAKSDYFRA-------RSSREILRVKGVSYSALRLLVDYLYTGHMGEVKQdNVAEVIAGARF 303
Cdd:cd18236   26 DVILCVDSQEFSCHRVVLAAASNYFRAmfcndlkEKYEEKIIIKGVDAETMQILLDYTYTSKVLITKQ-NVQRVLEAASL 104


                 ....
gi 611980830 304 LQMP 307
Cdd:cd18236  105 FQFL 108
BTB_POZ_KLHL40_KBTBD5 cd18340
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 231-329 2.69e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349649 [Multi-domain]  Cd Length: 134  Bit Score: 50.22  E-value: 2.69e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 231 DLVIEVAGHRIQAHKSVLAAKSDYFRAR-------SSREILRVKGVSYSALRLLVDYLYTGHMgEVKQDNVAEVIAGARF 303
Cdd:cd18340   29 DCVLKIKEKEFPCHRLVLAACSPYFRAMflsdleeSKKREIVLEDVDPDVMGKILHYIYTSEI-EITEQNVQDIFAAANM 107

                         90       100
                 ....*....|....*....|....*.
gi 611980830 304 LQMPCALQCATDAMRAQLTLGNCYQV 329
Cdd:cd18340  108 FQIPSIFTVCVSFLQKRLCLSNCLAI 133
BTB2_POZ_ABTB1_BPOZ1 cd18296
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 230-307 2.70e-07

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349605 [Multi-domain]  Cd Length: 121  Bit Score: 49.99  E-value: 2.70e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 230 PDLVIEVAGHRIQAHKSVLAAKSDYFRA------------RSSREILRVKGVSYSALRLLVDYLYTGHMgEVKQDNVAEV 297
Cdd:cd18296   18 PDVCFQVEGHRFPCHKAFFCGRSDYFKAllrdhfaeseenNGSIPVVTLHDVSPEVFAIVLYYIYTDDT-DLPPENAYDV 96

                         90
                 ....*....|
gi 611980830 298 IAGARFLQMP 307
Cdd:cd18296   97 LYVADMYLLP 106
BTB_POZ_KBTBD2_BKLHD1 cd18270
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 231-330 3.88e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349579 [Multi-domain]  Cd Length: 133  Bit Score: 49.62  E-value: 3.88e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 231 DLVIEVAGHRIQAHKSVLAAKSDYFRA-------RSSREILRVKGVSYSALRLLVDYLYTGHMGeVKQDNVAEVIAGARF 303
Cdd:cd18270   28 DIVLIVEGTEFPCHKMVLATCSSYFRAmfmsglsESKQTHVHLRNVDAATLQIIITYAYTGNLA-INDSTVEQLYETACF 106

                         90       100
                 ....*....|....*....|....*..
gi 611980830 304 LQMPCALQCATDAMRAQLTLGNCYQVL 330
Cdd:cd18270  107 LQVEDVLQRCREYLIKKINAENCVRLL 133
BTB_POZ_ZBTB29-like cd18216
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 231-307 4.33e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer proteins, Hic-1 and Hic-2; The family includes hypermethylated in cancer proteins, Hic-1 and Hic-2. Hic-1 is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Hic-2 is a homolog of tumor suppressor Hic-1 that functions as a transcriptional regulator. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349525 [Multi-domain]  Cd Length: 118  Bit Score: 49.07  E-value: 4.33e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 231 DLVIEVAGHRIQAHKSVLAAKSDYFRARSSREI---LRVKGVSYSALRLLVDYLYTGHM--GEVKQDNVAEVIAGARFLQ 305
Cdd:cd18216   22 DVIIVVENSLFRAHKNVLAASSGYFKSLVLHDNlihLDQDMVSPTVFQQILDFIYTGKLldSLFEEPNLSEVLAAANYLQ 101


                 ..
gi 611980830 306 MP 307
Cdd:cd18216  102 LP 103
BTB_POZ_ZBTB31_myoneurin cd18217
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 231-307 4.44e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349526 [Multi-domain]  Cd Length: 111  Bit Score: 48.98  E-value: 4.44e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 231 DLVIEVAGHRIQAHKSVLAAKSDYFRA---RSSREI--LRVKGVSYSALRLLVDYLYTGHMgEVKQDNVAEVIAGARFLQ 305
Cdd:cd18217   20 DCTIVIGQFQFKAHRNVLAAFSEYFGAqykDTEDNIvfLDQSQVSADGFQKLLEFIYTGNL-NLDSWNVAEIHQAASYLG 98


                 ..
gi 611980830 306 MP 307
Cdd:cd18217   99 ME 100
BTB_POZ_KLHL31_KBTBD1 cd18260
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 231-326 4.99e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349569 [Multi-domain]  Cd Length: 120  Bit Score: 49.04  E-value: 4.99e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 231 DLVIEVAGHRIQAHKSVLAAKSDYFRA----RSSREILRVKGVSYSALRLLVDYLYTGHMgEVKQDNVAEVIAGARFLQM 306
Cdd:cd18260   20 DLTIATKTKSFDVHKVVMASCSEYFRNilkkDPSLQRVELNDISPLGLATVITYAYTGKL-TLSLYTIGSTISAASYLQI 98

                         90       100
                 ....*....|....*....|
gi 611980830 307 PCALQCATDAMRAQLTLGNC 326
Cdd:cd18260   99 HALVKMCCDFLMQEMNVENC 118
BTB_POZ_ABTB2-like cd18297
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 231-320 5.12e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349606 [Multi-domain]  Cd Length: 117  Bit Score: 48.81  E-value: 5.12e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 231 DLVIEVAGHRIQAHKSVLAAKSDYFRA-------RSSREILRVKGVSYSALRLLVDYLYTGHMGE--VKQDNVAEVIAGA 301
Cdd:cd18297   14 DVTFLVEGRPFYAHKIVLVTASDRFKSmlssgstEAQTPVIEIPDIRYDIFQLMMQYLYTGGVESldVAQDDALELLRAA 93

                         90
                 ....*....|....*....
gi 611980830 302 RFLQMPcALQCATDAMRAQ 320
Cdd:cd18297   94 SFFQLD-GLKRHCEILLSQ 111
BTB_POZ_ZBTB8 cd18199
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 231-306 7.11e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349508 [Multi-domain]  Cd Length: 113  Bit Score: 48.57  E-value: 7.11e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 231 DLVIEVAGHRIQAHKSVLAAKSDYFRA----------RSSREILRVkgVSYSALRLLVDYLYTGHMgEVKQDNVAEVIAG 300
Cdd:cd18199   20 DCSIIVEGRIFKAHRNVLFASSGYFRMllshyiqdtgRPSTASFDV--FSSDAFSIILDFVYSGKL-SLTSQNVIEVMSA 96


                 ....*.
gi 611980830 301 ARFLQM 306
Cdd:cd18199   97 ASYLQM 102
BTB_POZ_KBTBD4 cd18272
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 231-330 7.17e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349581 [Multi-domain]  Cd Length: 140  Bit Score: 49.12  E-value: 7.17e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 231 DLVIEVAGHRIQAHKSVLAAKSDYFRA-------RSSREILRVKGVSYSALRLLVDYLYTGhMGEVKQDNVAEVIAGARF 303
Cdd:cd18272   34 DVTISVEGKEFQLHRLVLSAQSCFFRSmftsnlkEARNRVIELKDVSESVFQLLVDYIYHG-TVKLRVEELQETYEVADM 112

                         90       100
                 ....*....|....*....|....*..
gi 611980830 304 LQMPCALQCATDAMRAQLTLGNCYQVL 330
Cdd:cd18272  113 YQLTALFEECSRFLARTVQVRNCLQVM 139
BTB_POZ_KLHL9_13 cd18239
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 244-326 9.16e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13; KLHL9 and KLHL13 (also called BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes, thereby coordinating faithful mitotic progression and completion of cytokinesis. They contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349548 [Multi-domain]  Cd Length: 128  Bit Score: 48.65  E-value: 9.16e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 244 HKSVLAAKSDYFRAR-----SSREILRVK--GVSYSALRLLVDYLYTGHMgEVKQDNVAEVIAGARFLQMPCALQCATDA 316
Cdd:cd18239   40 HRAMMASASDYFKAMftggmKEQELMCIKlhGVSKIGLKNIIDFIYTAKL-SLNMDNLQDTLEAASFLQILPVLDFCKVL 118

                         90
                 ....*....|
gi 611980830 317 MRAQLTLGNC 326
Cdd:cd18239  119 LISGVTLENC 128
BTB_POZ_calicin cd18307
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 231-307 1.01e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa. It contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349616 [Multi-domain]  Cd Length: 97  Bit Score: 47.49  E-value: 1.01e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 231 DLVIEVAGHRIQAHKSVLAAKSDYFRAR-SSREI---------LRVKGVSYSALRLLVDYLYTGHMgEVKQDNVAEVIAG 300
Cdd:cd18307    3 DVVISVDNHSFAAHRNVLAAVSPFVKSLiSSNDMkatdelsitIDCDYLSPETVEQLLDYFYTGKI-VISEKNVEDLLKG 81


                 ....*..
gi 611980830 301 ARFLQMP 307
Cdd:cd18307   82 AKYFNIP 88
BACK_KLHL42_KLHDC5 cd18478
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 42 (KLHL42); KLHL42, also ...
 321-388 1.16e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 42 (KLHL42); KLHL42, also called Cullin-3-binding protein 9 (Ctb9), or Kelch domain-containing protein 5, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of KATNA1. KLHL42 is involved in microtubule dynamics throughout mitosis.


Pssm-ID: 350553  Cd Length: 103  Bit Score: 47.46  E-value: 1.16e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 611980830 321 LTLGNCYQVLSLAKQQRLSELREAAYRFMSDHYLQVLREPSiYGRLTGSERDLILQRRMEaGRSCLLV 388
Cdd:cd18478    1 IRLPNCLELYRLAQVYGLRDLAEACLKFMATHYHPMLRRPE-FRPLPSSLKQQLRERRLR-GTPALVA 66
BTB_POZ_ZBTB7 cd18198
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 231-317 1.33e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349507 [Multi-domain]  Cd Length: 120  Bit Score: 47.94  E-value: 1.33e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 231 DLVIEVAGHRIQAHKSVLAAKSDYFR-------ARSSREILRVKGVSYSALRLLVDYLYTGHMgEVKQDNVAEVIAGARF 303
Cdd:cd18198   27 DVVILVQGREYRTHRSVLAACSQYFKklftsgaVVDQQNVYEIDFVSPEALTALLEFAYTATL-TVSTANVGDILSAARL 105

                         90
                 ....*....|....
gi 611980830 304 LQMPCALQCATDAM 317
Cdd:cd18198  106 LEIPCVSHVCAEIL 119
BTB_POZ_KLHL19_KEAP1 cd18248
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 231-321 1.51e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349557 [Multi-domain]  Cd Length: 124  Bit Score: 47.76  E-value: 1.51e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 231 DLVIEVAGHRIQ----AHKSVLAAKSDYFRA-------RSSREILRVKGVSYSALRLLVDYLYTG--HMGEVkqdNVAEV 297
Cdd:cd18248   23 DVTLKVKYQDPKeefmAHKVVLASSSPYFKAmftsglrECGMEVVPIEGVHPCVMSRLIEFAYTAsiSVGEK---CVLHV 99

                         90       100
                 ....*....|....*....|....
gi 611980830 298 IAGARFLQMPCALQCATDAMRAQL 321
Cdd:cd18248  100 LPGAVMYQMDSVVKACCDFLEQQL 123
BTB_POZ_ZBTB27-like cd18215
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 231-307 1.87e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349524 [Multi-domain]  Cd Length: 113  Bit Score: 47.18  E-value: 1.87e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 231 DLVIEVAGHRIQAHKSVLAAKSDYF------RARSSREILRV-KGVSYSALRLLVDYLYTGHMGEvKQDNVAEVIAGARF 303
Cdd:cd18215   21 DVVLVVGREQFRAHKTVLMACSGLFysiftdQLKNNVSVINLdPEIEPEGFRILLDFMYTSRLNL-REGNIMAVMATAMY 99


                 ....
gi 611980830 304 LQMP 307
Cdd:cd18215  100 LQME 103
BTB_POZ_KBTBD12 cd18276
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 231-306 2.24e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349585 [Multi-domain]  Cd Length: 127  Bit Score: 47.49  E-value: 2.24e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 231 DLVIEVAGHRIQAHKSVLAAKSDYFRAR--------SSREILrVKGVSYSALRLLVDYLYTGHMgEVKQDNVAEVIAGAR 302
Cdd:cd18276   23 DVVLVAEGEKFPCHRLVLAAFSPYFKAMftcglmecSQREVV-LHDITAESVSIILNYMYSSDL-HLTNSNVQGVATAAF 100


                 ....
gi 611980830 303 FLQM 306
Cdd:cd18276  101 FLQM 104
BTB_POZ cd01165
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 233-304 2.52e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


Pssm-ID: 349496 [Multi-domain]  Cd Length: 79  Bit Score: 45.74  E-value: 2.52e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 611980830 233 VIEVAGHRIQAHKSVLAAKSDYFRA-------RSSREILRVKGVSYSALRLLVDYLYtGHMGEVKQDNVAEVIAGARFL 304
Cdd:cd01165    2 VLVVEGEKFHVNKELLAQSSEYFRAlfrggfrESGQAEINLRDISPEDFRALLEFLY-GGKRDLDASNLLELLEAANFL 79
BTB_POZ_NPR_plant cd18310
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 231-295 4.54e-06

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349619 [Multi-domain]  Cd Length: 145  Bit Score: 46.92  E-value: 4.54e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 231 DLVIEVAGHR-IQAHKSVLAAKSDYFR------ARSS---------REILRVKGVSYSALRLLVDYLYTGHMGEVKQDNV 294
Cdd:cd18310   20 DAEIIVEGGRpVPVHRCILAARSPFFRdifasaKAEGantkpklelRELIPGGIVGYDAFMLVLSYLYSGRLRLVPKEGS 99


                 .
gi 611980830 295 A 295
Cdd:cd18310  100 A 100
BTB_POZ_ZBTB49 cd18233
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 231-310 5.96e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49); ZBTB49, also called zinc finger protein 509 (ZNF509), is a transcription factor that inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. There are four ZNF509 isoforms generated by alternative splicing. Short ZNF509 (ZNF509S1, -S2 and -S3) isoforms contain one or two out of the seven zinc-fingers contained in long ZNF509 (ZNF509L). ZBTB49 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349542 [Multi-domain]  Cd Length: 112  Bit Score: 45.65  E-value: 5.96e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 231 DLVIEVAGHRIQAHKSVLAAKSDYFR------ARSSREILRVKGVSYSALRLLVDYLYTGHMgEVKQDNVAEVIAGARFL 304
Cdd:cd18233   20 DCMLVVKGVCFKAHKNVLAAFSQYFRslfqnsSSQKNDVFHLDIKNVGGIGQILDFMYTSHL-DLNQDNVQVMLDIAQCL 98


                 ....*.
gi 611980830 305 QMPCAL 310
Cdd:cd18233   99 QVQNVL 104
BTB_POZ_ZBTB17_MIZ1 cd18206
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 231-306 6.04e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349515 [Multi-domain]  Cd Length: 112  Bit Score: 45.69  E-value: 6.04e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 611980830 231 DLVIEVAGHRIQAHKSVLAAKSDYFRAR--SSREILRVKGVSYSALRLLVDYLYTGHMgEVKQDNVAEVIAGARFLQM 306
Cdd:cd18206   24 DCTFVVDGVDFKAHKAVLAACSEYFRMLfvDQKDVVHLDISNAAGLGQVLEFMYTAKL-SLSPENVDDVLAVATFLQM 100
BTB_POZ_ZBTB11 cd18202
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 231-311 6.42e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349511 [Multi-domain]  Cd Length: 118  Bit Score: 46.00  E-value: 6.42e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 231 DLVIEVAGHRIQAHKSVLAAKSDYFR-------ARSSRE-ILRVKGVSYSALRLLVDYLYTghmGEVKQD--NVAEVIAG 300
Cdd:cd18202   21 DVTLLIEGEEYKAHKSVLAANSEYFRelfiekgAVSSHEaVVDLSGFCKSSFLPLLEFAYT---SELTFDfcSMAEVAML 97

                         90
                 ....*....|.
gi 611980830 301 ARFLQMPCALQ 311
Cdd:cd18202   98 ARHLFMNEVLE 108
BTB_POZ_ZBTB8A_BOZF1 cd18329
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 231-306 6.96e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349638 [Multi-domain]  Cd Length: 116  Bit Score: 45.59  E-value: 6.96e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 231 DLVIEVAGHRIQAHKSVLAAKSDYFR---ARSSREILRVKGVSYSALR-----LLVDYLYTGHMgEVKQDNVAEVIAGAR 302
Cdd:cd18329   23 DCSILVEGQVFKAHRNVLFASSGYFKmllSQNAKETGQPTVATFDVFSpdtftIILDFVYSGKL-SLTSQNVIEVMSAAS 101


                 ....
gi 611980830 303 FLQM 306
Cdd:cd18329  102 YLQM 105
BTB_POZ_Rank-5 cd18303
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 231-326 7.02e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349612 [Multi-domain]  Cd Length: 120  Bit Score: 45.78  E-value: 7.02e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 231 DLVIEVAGHRIQAHKSVLAAKSDYFRAR--SSREILRVKGVSYSALRLLVDYLYTGHMgEVKQDNVA--EVIAGARFLQM 306
Cdd:cd18303   20 DITIKLADKSIPAHKFVLAARSEKWSNEnlASTNELDLSDISYEVVLALLRWLYTDEL-DLTLDDEFllELMKAAKRFQL 98

                         90       100
                 ....*....|....*....|
gi 611980830 307 PCALQCATDAMRAQLTLGNC 326
Cdd:cd18303   99 TDLVERCERALMSSVNVDNC 118
BTB_POZ_KLHL29_KBTBD9 cd18258
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 227-326 7.48e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349567 [Multi-domain]  Cd Length: 125  Bit Score: 45.73  E-value: 7.48e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 227 REEPDLVIEVAGHRIQAHKSVLAAKSDYFR---ARSSREI-------LRVKGVSYSALRLLVDYLYTGHMgEVKQDNVAE 296
Cdd:cd18258   15 KEFTDLKIIVEGKEFEVHQNVLASCSLYFKdliKRSSRDSgggekleLTMSNINADVLELLLEFVYTGSL-IIDSANAKT 93

                         90       100       110
                 ....*....|....*....|....*....|
gi 611980830 297 VIAGARFLQMPCALQCATDAMRAQLTLGNC 326
Cdd:cd18258   94 LLEAANKFQFHTFCKVCVSFLEKQLTASNC 123
BTB_POZ_KLHL40-like cd18269
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 231-326 1.14e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349578 [Multi-domain]  Cd Length: 133  Bit Score: 45.47  E-value: 1.14e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 231 DLVIEVAGHRIQAHKSVLAAKSDYFRAR-------SSREILRVKGVSYSALRLLVDYLYTGHMgEVKQDNVAEVIAGARF 303
Cdd:cd18269   29 DCVLKIGDKEFPCHRLVLAACSPYFRAMflsdleeSKKKEVVLEDVDPDVMGMILKYLYTSEI-DLNDQNVQDIFALASR 107

                         90       100
                 ....*....|....*....|...
gi 611980830 304 LQMPCALQCATDAMRAQLTLGNC 326
Cdd:cd18269  108 FQIPSIFTVCVSYLQKRLSLSNC 130
BTB_POZ_ZBTB7B_ZBTB15 cd18327
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 231-318 1.15e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349636 [Multi-domain]  Cd Length: 127  Bit Score: 45.22  E-value: 1.15e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 231 DLVIEVAGHRIQAHKSVLAAKSDYFR--------------ARSSREILRVKGVSYSALRLLVDYLYTGHMgEVKQDNVAE 296
Cdd:cd18327   27 DLTIKTRGLEYRTHRAVLAACSLYFRklftgggggsgdlgAGGGQDVCELDFVGPEALGALLEFAYTATL-TISSSNMRE 105

                         90       100
                 ....*....|....*....|..
gi 611980830 297 VIAGARFLQMPCALQCATDAMR 318
Cdd:cd18327  106 VLRAARLLEIPCVADACADILQ 127
BTB_POZ_ZBTB37 cd18222
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 231-306 1.46e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37); ZBTB37 may be involved in transcriptional regulation. It is differentially expressed in aryl hydrocarbon receptor (AhR)-KO mice compared with WT mice, and may potentially contribute to the aging phenotype of AhR-KO mice. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349531 [Multi-domain]  Cd Length: 123  Bit Score: 45.03  E-value: 1.46e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 231 DLVIEVAGHRIQAHKSVLAAKSDYFRARSSreILRVKGVSYSALR------LLVDYLYTGHMGeVKQDNVAEVIAGARFL 304
Cdd:cd18222   27 DIVVNVQGQSFRAHKVVLAASSPYFRDHMS--LNEMSTVSISVIKnptvfeQLLSFCYTGRIC-LQLADIISYLTAASFL 103


                 ..
gi 611980830 305 QM 306
Cdd:cd18222  104 QM 105
BTB_POZ_ZBTB48_TZAP_KR3 cd18232
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 231-311 1.47e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349541 [Multi-domain]  Cd Length: 108  Bit Score: 44.36  E-value: 1.47e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 231 DLVIEVAGHRIQAHKSVLAAKSDYFRAR----SSREILRVKGVSySALRLLVDYLYTGHMGeVKQDNVAEVIAGARFLQM 306
Cdd:cd18232   20 DATLDVGGRVFKAHWSVLACCSHFFQSLygdgTSGSVVLPESFA-EVFGLLLDFFYTGELA-LTRENRDRVLLAAKELRV 97


                 ....*
gi 611980830 307 PCALQ 311
Cdd:cd18232   98 PEAVE 102
BTB_POZ_TDPOZ cd18344
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 224-301 2.17e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349653 [Multi-domain]  Cd Length: 128  Bit Score: 44.56  E-value: 2.17e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 224 GALREEP---DLVIEVAGHRIQAHKSVLAAKSDYFRARSSREI-------LRVKGVSYSALRLLVDYLYTGHMGEVKQDN 293
Cdd:cd18344   15 GELWENSlftDCCLLVAGHEFRAHKAILAARSPVFRAMFEHEMeerlknpIEIHDLDPQVFKEMMGFIYTGKAPHLHSHS 94


                 ....*....
gi 611980830 294 VA-EVIAGA 301
Cdd:cd18344   95 MAcDVLAAA 103
BTB_POZ_ZBTB10 cd18201
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 231-321 2.22e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349510 [Multi-domain]  Cd Length: 122  Bit Score: 44.56  E-value: 2.22e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 231 DLVIEVAGHRIQAHKSVLAAKSDYFR---------ARSSREILRVKGVSYSALRLLVDYLYTGHMGEVKQdNVAEVIAGA 301
Cdd:cd18201   23 DVNIVVSGKVFRAHKNILVAGSRFFKtlycftnkeSCDQTTVTHLDVVAVQGFSVILDFMYSGNLVLTSQ-NAIEVMSVA 101

                         90       100
                 ....*....|....*....|
gi 611980830 302 RFLQMPCALQCATDAMRAQL 321
Cdd:cd18201  102 SYLQMTEVVQSCRNFIKDAL 121
BTB2_POZ_KLHL33 cd18263
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 231-326 2.26e-05

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349572 [Multi-domain]  Cd Length: 118  Bit Score: 44.42  E-value: 2.26e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 231 DLVIEVAGHRIQAHKSVLAAKSDYFRA------RSSRE-ILRVKGVSYSALRLLVDYLYTGHMgEVKQDNVAEVIAGARF 303
Cdd:cd18263   15 DVQLEADGSIFRVHRVILAAGSDYFRAmftsgmKESTQsVVQLPTIPAKDLRLLISFAYSGIL-HLSWENLFEATCTALQ 93

                         90       100
                 ....*....|....*....|...
gi 611980830 304 LQMPCALQCATDAMRAQLTLGNC 326
Cdd:cd18263   94 LQISGALALCLDFLQREISPARC 116
BTB_POZ_KLHL32 cd18261
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 231-306 2.36e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349570 [Multi-domain]  Cd Length: 133  Bit Score: 44.57  E-value: 2.36e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 231 DLVIEVAGHRIQAHKSVLAAKSDYFRA-------RSSREILRVKGVSYSALRLLVDYLYTGHMgEVKQDNVAEVIAGARF 303
Cdd:cd18261   30 DITLVAEEQKFHAHKAVLAACSDYFRAmfslcmvESEADEVNLHGVTSLGLKQALDFAYTGQI-LLEPGVIQDVLAAGSH 108


                 ...
gi 611980830 304 LQM 306
Cdd:cd18261  109 LQL 111
BTB_POZ_BACH1 cd18277
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 231-304 2.59e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349586 [Multi-domain]  Cd Length: 120  Bit Score: 44.29  E-value: 2.59e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 231 DLVIEVAGHRIQAHKSVLAAKSDYFRAR------SSREILRVKGVSYSALRLLVDYLYTGHMgEVKQDNVAEVIAGARFL 304
Cdd:cd18277   29 DVTILVEGQRFRAHRSVLAACSSYFHSRivgqadAELNITLPEEVTVKGFEPLIQFAYTAKL-ILSKDNVDEVCKCVEFL 107
BTB_POZ_KLHL36 cd18266
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 231-306 2.93e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349575 [Multi-domain]  Cd Length: 135  Bit Score: 44.50  E-value: 2.93e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 231 DLVIEVAGHRIQAHKSVLAAKSDYF--------RARSSREILRVkGVSYSALRLLVDYLYTGHMgEVKQDNVAEVIAGAR 302
Cdd:cd18266   27 DVVLVADEQRVPAHRNLLAVCSDYFnsmftigmREAHQKEVELV-GASYIGLKAVIDFLYSSEL-PLDGGNIDYVLETAH 104


                 ....
gi 611980830 303 FLQM 306
Cdd:cd18266  105 LLQI 108
PRK14131 PRK14131
N-acetylneuraminate epimerase;
518-583 2.96e-05

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 46.93  E-value: 2.96e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 611980830 518 QPRSQLKLLALDGYLYAVGG----------ECLFSVERYDPRTDRWSAVAPLPKGGFAVAHEATTCNGEIYVSGGS 583
Cdd:PRK14131  73 GPREQAVAAFIDGKLYVFGGigktnsegspQVFDDVYKYDPKTNSWQKLDTRSPVGLAGHVAVSLHNGKAYITGGV 148
BTB_POZ_KLHL23 cd18252
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 236-326 3.00e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349561 [Multi-domain]  Cd Length: 127  Bit Score: 44.05  E-value: 3.00e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 236 VAGHRIQAHKSVLAAKSDYFRA-------RSSREILRVKGVSYSALRLLVDYLYTGHMgEVKQDNVAEVIAGARFLQMPC 308
Cdd:cd18252   29 ASGQIFHCHKAALAACSSYFKVmftadmkEKSNNVIKLSGIDHDILEALVNYVYTSQI-CITERNVQSLLEAADLLQFIS 107

                         90
                 ....*....|....*...
gi 611980830 309 ALQCATDAMRAQLTLGNC 326
Cdd:cd18252  108 VKKACEQFLVRHLDIDNC 125
BTB_POZ_BACH cd18955
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 231-306 3.56e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349736 [Multi-domain]  Cd Length: 94  Bit Score: 43.23  E-value: 3.56e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 231 DLVIEVAGHRIQAHKSVLAAKSDYFRAR------SSREILRVKGVSYSALRLLVDYLYTGHMgEVKQDNVAEVIAGARFL 304
Cdd:cd18955    3 DVTIVVEDQRFRAHRAVLAACSDYFLSRvvgqtdGDLVITLPEEVTVKGFEPLLQFAYTAKL-LLSKENVLEVCRCAEFL 81


                 ..
gi 611980830 305 QM 306
Cdd:cd18955   82 GV 83
BTB_POZ_BTBD19 cd18294
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 241-301 4.44e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349603 [Multi-domain]  Cd Length: 111  Bit Score: 43.39  E-value: 4.44e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 611980830 241 IQAHKSVLAAKSDYFRA--------RSSREILRVKGVSYSALRLLVDYLYTGHMGEVKqDNVAEVIAGA 301
Cdd:cd18294   28 IFAHKCILAARCEVFRAmfltgpqkESTQSPLVLSDIEPEVFRAVLEFIYTNCVTLSN-HTVIEVLAAA 95
BTB_POZ_KLHL17_actinfilin cd18246
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 231-306 4.45e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349555 [Multi-domain]  Cd Length: 139  Bit Score: 43.87  E-value: 4.45e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 231 DLVIEVAGHRIQAHKSVLAAKSDYFRARSSREILRVK-------GVSYSALRLLVDYLYTGHMgEVKQDNVAEVIAGARF 303
Cdd:cd18246   41 DIVLHVGTKEIKAHKVVLASCSPYFHAMFTNEMSESRqthvtlhDIDPQALEQLVQYAYTAEI-VVGEGNVQTLLPAASL 119


                 ...
gi 611980830 304 LQM 306
Cdd:cd18246  120 LQL 122
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 468-517 5.64e-05

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 41.06  E-value: 5.64e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 611980830  468 KGCAMCILYNYLFLAGGIlqggpeGRPRLSDKVFCYNPVTDTWTTVRSLS 517
Cdd:pfam01344   3 SGAGVVVVGGKIYVIGGF------DGNQSLNSVEVYDPETNTWSKLPSMP 46
BTB_POZ_ZBTB42 cd18956
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 231-306 6.05e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 42 (ZBTB42); ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. It is enriched in skeletal muscles, especially at the neuromuscular junction. A ZBTB42 mutation has been identified to define a novel lethal congenital contracture syndrome (LCCS6), a lethal autosomal recessive form of arthrogryposis multiplex congenita (AMC). ZBTB42 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349737 [Multi-domain]  Cd Length: 129  Bit Score: 43.26  E-value: 6.05e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 231 DLVIEVAGHRIQAHKSVLAAKSDYF------RARSSREILRVKG--VSYSALRLLVDYLYTGHMgEVKQDNVAEVIAGAR 302
Cdd:cd18956   25 DCTVLVGDARFPAHRAVLAACSVYFhlfyrdRPAGGRDTVRLNGdiVTAPAFGRLLDFMYEGRL-DLRSLPVEDVLAAAS 103


                 ....
gi 611980830 303 FLQM 306
Cdd:cd18956  104 YLHM 107
Kelch_3 pfam13415
Galactose oxidase, central domain;
477-521 7.00e-05

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 40.74  E-value: 7.00e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 611980830  477 NYLFLAGGIlqgGPEGRPRLSDkVFCYNPVTDTWTTVRSLSQPRS 521
Cdd:pfam13415   2 DKLYIFGGL---GFDGQTRLND-LYVYDLDTNTWTQIGDLPPPRS 42
Kelch_6 pfam13964
Kelch motif;
519-562 9.81e-05

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 40.40  E-value: 9.81e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 611980830  519 PRSQLKLLALDGYLYAVGGECLFS-----VERYDPRTDRWSAVAPLPKG 562
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYTNASpalnkLEVYNPLTKSWEELPPLPTP 49
BACK cd14733
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 322-361 1.02e-04

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


Pssm-ID: 350515 [Multi-domain]  Cd Length: 55  Bit Score: 40.72  E-value: 1.02e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 611980830 322 TLGNCYQVLSLAKQQRLSELREAAYRFMSDHYLQVLREPS 361
Cdd:cd14733    1 DPENCLGILELADLYNLEELKEKALKFILENFEEVSKSEE 40
BTB_POZ_ZBTB3-like cd18194
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 231-306 1.19e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349503 [Multi-domain]  Cd Length: 128  Bit Score: 42.50  E-value: 1.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 231 DLVIEVAGHRIQAHKSVLAAKSDYF----RAR-SSREILRVKG--VSYSALRLLVDYLYTGHMgEVKQDNVAEVIAGARF 303
Cdd:cd18194   25 DCTVLVGSAQFPAHRAVLASCSMYFhlfyRDRlDKRDLVRLNSdiVTAPAFGLLLDFMYEGRL-ALRDLPVEDVLAAASY 103


                 ...
gi 611980830 304 LQM 306
Cdd:cd18194  104 LHM 106
BTB_POZ_ZBTB30_HIC2 cd18334
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 231-307 1.26e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349643 [Multi-domain]  Cd Length: 120  Bit Score: 42.26  E-value: 1.26e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 231 DLVIEVAGHRIQAHKSVLAAKSDYFRA---RSSREILRVKGVSYSALRLLVDYLYTGHMGEVKQ---DNVAEVIAGARFL 304
Cdd:cd18334   23 DVIIVVENALFRAHKNILAASSMYFKSlvlHDNLINLDTDMVNPTVFRQILDFIYTGKLLTSDQpgeQNFNALLTAASYL 102


                 ...
gi 611980830 305 QMP 307
Cdd:cd18334  103 QLH 105
BTB_POZ_BTBD14A_NAC2 cd18289
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 231-317 1.43e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349598 [Multi-domain]  Cd Length: 131  Bit Score: 42.32  E-value: 1.43e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 231 DLVIEVAGHRIQAHKSVLAAKSDYFR---ARSSREILRVKG-VSYSALRLLVDYLYTGHMGEVKQDNVAeVIAGARFLQM 306
Cdd:cd18289   31 DVSIVVKGQAFKAHRAVLAASSLYFRdlfSGNSKSAFELPAtVPPACFQQILSFCYTGKLTMAASEQLV-VMYTAGFLQI 109

                         90
                 ....*....|.
gi 611980830 307 PCALQCATDAM 317
Cdd:cd18289  110 QHIVERGTDLM 120
BTB_POZ_RCBTB1_2 cd18298
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 228-284 2.22e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349607 [Multi-domain]  Cd Length: 108  Bit Score: 41.09  E-value: 2.22e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 611980830 228 EEPDLVIEVAGHRIQAHKSVLAAKSDYFRA-------RSSREILRVKGVSYSALRLLVDYLYTG 284
Cdd:cd18298   11 RTSDLKFRVDGKYIYVHKAILKIRCEYFRSmfqshwnEDDKNVIEIDQYSYPVYYAFLRYLYTD 74
BTB1_POZ_IBtk cd18301
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 231-284 2.33e-04

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349610 [Multi-domain]  Cd Length: 99  Bit Score: 40.73  E-value: 2.33e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 611980830 231 DLVIEVAGHRIQAHKSVLAAKSDYFRA--RSSREILRVKG---------VSYSALRLLVDYLYTG 284
Cdd:cd18301   20 DVVFQVGGKTFPAHKFILASRSDYFRKlfLSSLLTSEDAVgcdvvhiekVPPEIFEQLLQFIYTD 84
BTB_POZ_ZBTB20_DPZF cd18208
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 231-306 2.60e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20); ZBTB20, also called dendritic-derived BTB/POZ zinc finger protein (DPZF) or zinc finger protein 288, may be a transcription factor involved in hematopoiesis, oncogenesis, and immune responses. It is an essential regulator of hepatic lipogenesis and may be a therapeutic target for the treatment of fatty liver disease. It also functions as a critical regulator of anterior pituitary development and lactotrope specification. Moreover, it promotes astrocytogenesis during neocortical development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349517 [Multi-domain]  Cd Length: 117  Bit Score: 41.20  E-value: 2.60e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 231 DLVIEVAGHRIQAHKSVLAAKSDYFRAR-----SSREILRVkgVSYSALRLLVDYLYTGHMgEVKQDNVAEVIAGARFLQ 305
Cdd:cd18208   27 DVTVRIHGSMLRAHRCVLAAGSPFFQDKlllgySDIEIPSV--VSVQSVQKLIDFMYSGVL-RVSQSEALQILTAASILQ 103


                 .
gi 611980830 306 M 306
Cdd:cd18208  104 I 104
BTB_POZ_KLHL11 cd18241
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 238-326 2.62e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349550 [Multi-domain]  Cd Length: 135  Bit Score: 41.77  E-value: 2.62e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 238 GHRIQAHKSVLAAKSDYF---------RARSSREILR----VKGVSYSALRLLVDYLYTGHMgEVKQDNVAEVIAGA-RF 303
Cdd:cd18241   35 GREFRAHRSVLAAATEYFtpllsgqfsESRSGRVEMRkwssEPGPDPDTVEAVIQYMYTGRI-RVSTGNVHEVLELAdRF 113

                         90       100
                 ....*....|....*....|...
gi 611980830 304 LQMPCALQCAtDAMRAQLTLGNC 326
Cdd:cd18241  114 LLIRLKEFCG-EFLKKKLNLSNC 135
BTB_POZ_KLHL42 cd18319
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 245-305 2.78e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 42 (KLHL42); KLHL42, also called Cullin-3-binding protein 9 (Ctb9) or Kelch domain-containing protein 5, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of katanin (KATNA1). KLHL42 is involved in microtubule dynamics throughout mitosis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349628 [Multi-domain]  Cd Length: 93  Bit Score: 40.63  E-value: 2.78e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 611980830 245 KSVLAAKSDYFRA-------RSSREILRVKGVSYSALRLLVDYLYTGHMGEVKQDN---------VAEVIAGARFLQ 305
Cdd:cd18319   17 KRKLIEQSDYFRAlyrsgmrESGEEVVQLRGLSAPGLELVLDFINTSKVHESQGDStdtleenelLEDLVEAASFLQ 93
PRK14131 PRK14131
N-acetylneuraminate epimerase;
449-521 2.78e-04

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 43.85  E-value: 2.78e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 611980830 449 QEADKEWKVLTRLPEGANaKGCAMCILYNYLFLAGGILQGGPEGRPRLSDKVFCYNPVTDTWTTVRSLSqPRS 521
Cdd:PRK14131  58 NAPSKGWTKIAAFPGGPR-EQAVAAFIDGKLYVFGGIGKTNSEGSPQVFDDVYKYDPKTNSWQKLDTRS-PVG 128
BTB_POZ_ZBTB43 cd18227
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 231-306 2.85e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43); ZBTB43, also called zinc finger and BTB domain-containing protein 22B (ZBTB22b), zinc finger protein 297B (ZNF297B), or ZnF-x, may be involved in transcriptional regulation. It interacts with BDP1, a subunit of transcription factor IIIB (TFIIIB). Since BDP1 is essential in Pol III transcription, ZBTB43 may also regulate these transcriptional pathways. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349536 [Multi-domain]  Cd Length: 121  Bit Score: 41.08  E-value: 2.85e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 231 DLVIEVAGHRIQAHKSVLAAKSDYF----RARSSREILRVKGVSYSALRLLVDYLYTGHMgEVKQDNVAEVIAGARFLQM 306
Cdd:cd18227   27 DISVVVQGHLFRAHKAVLAASSPYFcdqvLLKNSRRIVLPDVMNPRVFENILLSCYTGRL-VLPAPEIVSYLTAASFLQM 105
BTB_POZ_SPOP-like cd18279
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 231-284 2.94e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349588 [Multi-domain]  Cd Length: 120  Bit Score: 40.98  E-value: 2.94e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 611980830 231 DLVIEVAGHRIQAHKSVLAAKSDYFRARSSREI-------LRVKGVSYSALRLLVDYLYTG 284
Cdd:cd18279   20 DCCLCVGGQEFQAHKAILAARSPVFSAMFEHEMeeskknrVEINDVDPEVFKEMMRFIYTG 80
BTB_POZ_RCBTB1_CLLD7 cd18353
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 228-283 3.29e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1); RCBTB1 is also called chronic lymphocytic leukemia deletion region gene 7 protein (CLLD7), CLL deletion region gene 7 protein, regulator of chromosome condensation and BTB domain-containing protein 1, or E4.5. It is a novel chromosome condensation regulator-like guanine nucleotide exchange factor that may be involved in cell cycle regulation by chromatin remodeling. It may also function as a tumor suppressor that regulates pathways of DNA damage/repair and apoptosis. RCBTB1 may also be a substrate adaptor for a cullin3 (CUL3) E3 ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Biallelic mutations in RCBTB1 may cause isolated and syndromic retinal dystrophy. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349662 [Multi-domain]  Cd Length: 117  Bit Score: 41.09  E-value: 3.29e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 611980830 228 EEPDLVIEVAGHRIQAHKSVLAAKSDYFRA-------RSSREILRVKGVSYSALRLLVDYLYT 283
Cdd:cd18353   19 ETSDLKFRVDGKYIHVHKAVLKIRCEHFRTmfqshwnEDMKEVIEIDQFSYPVYRAFLEYLYT 81
BTB_POZ_ZBTB7C_ZBTB36 cd18328
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 231-317 3.63e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349637 [Multi-domain]  Cd Length: 120  Bit Score: 41.02  E-value: 3.63e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 231 DLVIEVAGHRIQAHKSVLAAKSDYFRA-------RSSREILRVKGVSYSALRLLVDYLYTGHMgEVKQDNVAEVIAGARF 303
Cdd:cd18328   27 DVVLIVQDQEYRTHRSVLAACSKYFKKlftagtlADQPYVYEIDFVTPEALSAILEFAYTSTL-TITTSNVKHILNAAQM 105

                         90
                 ....*....|....
gi 611980830 304 LQMPCALQCATDAM 317
Cdd:cd18328  106 LEIQCIINVCLEIM 119
BTB_POZ_ZBTB24_ZNF450 cd18212
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 231-307 3.70e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349521 [Multi-domain]  Cd Length: 118  Bit Score: 40.93  E-value: 3.70e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 231 DLVIEVAGHRIQAHKSVLAAKSDYFRARSSRE------ILRVKGVSYSALRLLVDYLYTGHMgEVKQDNVAEVIAGARFL 304
Cdd:cd18212   25 DITLIVENVQFRAHKALLAASSEYFSMMFADEgevgqsIYMLEGMVAETFGALLEFIYTGCL-QVGEKSLEQILATAQFL 103


                 ...
gi 611980830 305 QMP 307
Cdd:cd18212  104 KVN 106
BTB_POZ_BTBD11 cd18351
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 227-313 5.47e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 11 (BTBD11); BTBD11, also called ankyrin repeat and BTB/POZ domain-containing protein BTBD11, is a BTB-domain-containing protein. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349660 [Multi-domain]  Cd Length: 131  Bit Score: 40.73  E-value: 5.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 227 REEPDLVIEVAGHRIQAHKSVLAAKSDYFRA----RSSRE--ILRVKGVSYSALRLLVDYLYTGHMGE--VKQDNVAEVI 298
Cdd:cd18351   22 KEMSDVTFLVEGRPFYAHKVLLFTASPRFKAllsnKPSAEntCIEISYVKYHIFQLVMQYLYCGGTESllIKNNEIMELL 101

                         90       100
                 ....*....|....*....|
gi 611980830 299 AGARFLQMP-----CALQCA 313
Cdd:cd18351  102 SAAKFFQLEalqrhCEIICA 121
BTB_POZ_KLHL41_KBTBD10 cd18341
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 244-329 5.49e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349650 [Multi-domain]  Cd Length: 133  Bit Score: 40.60  E-value: 5.49e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 244 HKSVLAAKSDYFRARSSREILRVKG-------VSYSALRLLVDYLYTGHMgEVKQDNVAEVIAGARFLQMPCALQCATDA 316
Cdd:cd18341   42 HRLILAACSPYFREYFLSEESEEKKkevvldnVDPNIMDMILKYLYSAEI-DLNDGNVQDIFALASRFQIPSVFTVCVTY 120

                         90
                 ....*....|...
gi 611980830 317 MRAQLTLGNCYQV 329
Cdd:cd18341  121 LQKRLSPANCLAI 133
BTB_POZ_ZBTB19_PATZ1 cd18207
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 231-306 9.04e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349516 [Multi-domain]  Cd Length: 128  Bit Score: 39.95  E-value: 9.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 231 DLVIEVAGHRIQAHKSVLAAKSDYFRA---------RSSREiLRVKGVSYSALRLLVDYLYTGHMgEVKQDNVAEVIAGA 301
Cdd:cd18207   29 DVLLRVGEESFPAHRAVLAACSEYFESvfsaqegdgGTPRE-LEMHTISSKVFGDILDFAYTSRI-VVRLESFPELMTAA 106


                 ....*
gi 611980830 302 RFLQM 306
Cdd:cd18207  107 KFLLM 111
BTB_POZ_ZBTB18_2-like cd18325
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 231-306 1.00e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18.2 and similar proteins; This subfamily is composed of Xenopus laevis zinc finger and BTB domain-containing protein 18.2, encoded by the znf238.2.L gene, and similar proteins. Many proteins in this group are annotated as zinc finger and BTB domain-containing protein 42 (ZBTB42). However, characterized mammalian ZBTB42 does not belong to this subfamily. ZBTB18.2, like ZBTB18, functions as a transcriptional repressor that plays a role in various developmental processes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349634 [Multi-domain]  Cd Length: 128  Bit Score: 40.02  E-value: 1.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 231 DLVIEVAGHRIQAHKSVLAAKSDYFR-----ARSSREILRVKG--VSYSALRLLVDYLYTGHMgEVKQDNVAEVIAGARF 303
Cdd:cd18325   25 DCTVLVGEAQFRAHRAVLASCSMYFHlfyrdQLDKRDIVHLNSdiVTAPAFSLLLEFMYEGKL-EFSSLPVEDVLAAASY 103


                 ...
gi 611980830 304 LQM 306
Cdd:cd18325  104 LHM 106
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 568-602 1.08e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 37.21  E-value: 1.08e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 611980830  568 HEATTCNGEIYVSGGSLFYRLLK----YDPRRDEWQECP 602
Cdd:pfam01344   5 AGVVVVGGKIYVIGGFDGNQSLNsvevYDPETNTWSKLP 43
BTB1_POZ_KLHL33 cd18262
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 226-307 1.41e-03

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349571 [Multi-domain]  Cd Length: 101  Bit Score: 38.73  E-value: 1.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 226 LREEP---DLVIEVAGHRIQAHKSVLAAKSDYFRAR---SSREILRVKG-VSYSALRLLVDYLYTGHMGEVKqDNVAEVI 298
Cdd:cd18262   12 LREQRlllDETVSVGGRSYGVHSVILAAVSSLFRERllgSNGPLPPLSLeVTPVGWEAVLTFAYTGVLGRNP-ATVGDIL 90


                 ....*....
gi 611980830 299 AGARFLQMP 307
Cdd:cd18262   91 VAAEALGAP 99
BTB_POZ_roadkill-like cd18345
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 231-284 1.48e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349654 [Multi-domain]  Cd Length: 121  Bit Score: 39.06  E-value: 1.48e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 611980830 231 DLVIEVAGHRIQAHKSVLAAKSDYFRARSSREI-------LRVKGVSYSALRLLVDYLYTG 284
Cdd:cd18345   20 DVTLCVGGREFQAHKAILAARSPVFNAMFEHEMeerkqnrVEITDVDHEVMREMLRFIYTG 80
BTB2_POZ_LZTR1 cd18309
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 231-259 1.56e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349618 [Multi-domain]  Cd Length: 126  Bit Score: 39.29  E-value: 1.56e-03
                         10        20        30
                 ....*....|....*....|....*....|.
gi 611980830 231 DLVIEVAGHRIQAHKSVLAAKSDYFRA--RS 259
Cdd:cd18309   22 DITLLLDGHPIPAHKAILAARCSYFEAmfRS 52
BTB_POZ_ETO1-like cd18190
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 231-301 2.02e-03

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana ethylene-overproduction protein 1 (ETO1) and similar proteins; ETO1, also called protein ethylene overproducer 1, is an essential regulator of the ethylene pathway, which acts by regulating the stability of 1-aminocyclopropane-1-carboxylate synthase (ACS) enzymes. It may act as a substrate-specific adaptor that connects ACS enzymes, such as ACS5, to ubiquitin ligase complexes, leading to proteasomal degradation of ACS enzymes. The family also includes ETO1-like proteins 1 (EOL1) and 2 (EOL2). ETO1, EOL1, and EOL2 contain a BTB domain and tetratricopeptide (TPR) repeats. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349499 [Multi-domain]  Cd Length: 83  Bit Score: 37.88  E-value: 2.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 231 DLVIEVAGHRIQAHKSVLAAKSDYFRAR---SSREILRV------KGVSYSALRLLVDYLYTGHMGEVKQDNVAEVIAGA 301
Cdd:cd18190    1 DLVFCVGGEKFCCVRKKIASLSRPFKAMlygNFRESTSDcidfeeNGISIEAMRAVIDFSVTGRLDLFSVENVHEVLELA 80
BTB_POZ_ZBTB27_BCL6 cd18331
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 231-306 2.22e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6); BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349640 [Multi-domain]  Cd Length: 118  Bit Score: 38.68  E-value: 2.22e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 231 DLVIEVAGHRIQAHKSVLAAKSDYFRA-------RSSREILRVKGVSYSALRLLVDYLYTGHMGeVKQDNVAEVIAGARF 303
Cdd:cd18331   26 DVVIVVSREQFRAHKTVLMACSGLFYSiftdqlkCNLSVINLDPEINPEGFNILLDFMYTSRLN-LREGNIMAVMATAMY 104


                 ...
gi 611980830 304 LQM 306
Cdd:cd18331  105 LQM 107
BTB_POZ_BTBD14B_NAC1 cd18290
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 231-306 2.74e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349599 [Multi-domain]  Cd Length: 123  Bit Score: 38.48  E-value: 2.74e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 231 DLVIEVAGHRIQAHKSVLAAKSDYFR---ARSSREILRVKG-VSYSALRLLVDYLYTGHMGEvkqdNVAE---VIAGARF 303
Cdd:cd18290   29 DVSVVVKGHAFKAHRAVLAASSSYFRdlfNSSRSAVVELPAaVQPQSFQQILSFCYTGRLSM----NVGDqflLMYTAGF 104


                 ...
gi 611980830 304 LQM 306
Cdd:cd18290  105 LQI 107
Kelch_6 pfam13964
Kelch motif;
477-520 3.11e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 36.16  E-value: 3.11e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 611980830  477 NYLFLAGGILQGGPegrprLSDKVFCYNPVTDTWTTVRSLSQPR 520
Cdd:pfam13964  12 GYIYVFGGYTNASP-----ALNKLEVYNPLTKSWEELPPLPTPR 50
BTB_POZ_BACH2 cd18278
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 231-306 4.57e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349587 [Multi-domain]  Cd Length: 124  Bit Score: 38.01  E-value: 4.57e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 231 DLVIEVAGHRIQAHKSVLAAKSDYF------RARSSREILRVKGVSYSALRLLVDYLYTGHMgEVKQDNVAEVIAGARFL 304
Cdd:cd18278   33 DVTLIVEGKEFRAHRAVLAACSEYFlqalvgQTENDLVVSLPEEVTARGFGPLLQFAYTAKL-LLSRENIQEVIRCAEFL 111


                 ..
gi 611980830 305 QM 306
Cdd:cd18278  112 RM 113
BTB_POZ_BPM_plant cd18280
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 227-283 5.70e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349589 [Multi-domain]  Cd Length: 121  Bit Score: 37.31  E-value: 5.70e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 611980830 227 REEPDLVIEVAGHRIQAHKSVLAAKSDYFRA--------RSSREIlRVKGVSYSALRLLVDYLYT 283
Cdd:cd18280   12 EEGADVTFNVDGEKFRAHKLVLAARSPVFRSmlfgpmreENEGEI-VIEDVEPPVFKALLHFIYK 75
Kelch smart00612
Kelch domain;
498-521 6.98e-03

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 35.23  E-value: 6.98e-03
                           10        20
                   ....*....|....*....|....
gi 611980830   498 DKVFCYNPVTDTWTTVRSLSQPRS 521
Cdd:smart00612  15 KSVEVYDPETNKWTPLPSMPTPRS 38
BTB_POZ_ZBTB47_ZNF651 cd18231
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 231-306 8.53e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349540 [Multi-domain]  Cd Length: 115  Bit Score: 36.82  E-value: 8.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611980830 231 DLVIEVAGHRIQAHKSVLAAKSDYFRA--RSSREILRV----KGVSYSALRLLVDYLYTGHMgEVKQDNVAEVIAGARFL 304
Cdd:cd18231   18 DIVLVRQRSTFPAHKGVLAAYSQFFHSlfTQNKQLQRVelslEALTSQGLQQILNFIYTSKL-LVNSCNVQDVLNAAAVL 96


                 ..
gi 611980830 305 QM 306
Cdd:cd18231   97 QM 98
BTB_POZ_BT cd18313
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 229-283 8.98e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana BTB/POZ and TAZ domain-containing proteins, BT1-5; BT1-5 may act as substrate-specific adaptors of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. They contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349622 [Multi-domain]  Cd Length: 102  Bit Score: 36.30  E-value: 8.98e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 611980830 229 EPDLVIEVAGHR-IQAHKSVLAAKSDYF-------RARSSREILRVKGVSYSALRLLVDYLYT 283
Cdd:cd18313    1 GADVEIETDNNShIPAHSNVLASASPVIagmlkqpRRKSSKKVIKILGVPCDAVRVFIRFLYS 63
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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