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Conserved domains on  [gi|640776538|ref|XP_008051215|]
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toll-like receptor 1 [Carlito syrichta]

Protein Classification

toll-like receptor( domain architecture ID 17988233)

toll-like receptor (TLR) is involved in the recognition of microbial pathogens by the innate immune system, which recognize different pathogen-associated molecular patterns

CATH:  3.40.50.10140|3.80.10.10
Gene Ontology:  GO:0005515|GO:0002224|GO:0006955|GO:0004888|GO:0038187
PubMed:  18227810|16675322|34199501|16822173|11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
636-779 9.77e-42

Toll - interleukin 1 - resistance;


:

Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 149.01  E-value: 9.77e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640776538   636 QFHAFVSYSGHDsnWVKNELLPNLEKEN--IQICLHERNFVPGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYF 713
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEKLrgYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 640776538   714 AHHNLFHEGSNNLILILLEPIPQYsIPSSYHKLKTLMvRRTYLEWPKEKSKHglFWANLRAAINIK 779
Cdd:smart00255  79 ALENALEEGGLRVIPIFYEVIPSD-VRKQPGKFRKVF-KKNYLKWPEDEKEQ--FWKKALYAVPSK 140
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
352-526 3.32e-14

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 75.36  E-value: 3.32e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640776538 352 YLDLSNNLLTDtVFESCGSLTDLETLTLQRNQLKELAKIVtmtKEMKSLQQLDISQNSVRY-NENGRNCswtKSLLRLNM 430
Cdd:COG4886  117 SLDLSGNQLTD-LPEELANLTNLKELDLSNNQLTDLPEPL---GNLTNLKSLDLSNNQLTDlPEELGNL---TNLKELDL 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640776538 431 SSNILTD--SVFRCLPpRIKVLDLHKNRISSIPKGITCLEALQELNVAFNSLTDLPGCGTLSSLLVLIIDHNSVShpSVD 508
Cdd:COG4886  190 SNNQITDlpEPLGNLT-NLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLT--DLP 266

                        170
                 ....*....|....*...
gi 640776538 509 FFQSCQKIRSIKAGNNPF 526
Cdd:COG4886  267 PLANLTNLKTLDLSNNQL 284
LRR super family cl34836
Leucine-rich repeat (LRR) protein [Transcription];
32-152 5.48e-10

Leucine-rich repeat (LRR) protein [Transcription];


The actual alignment was detected with superfamily member COG4886:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 62.26  E-value: 5.48e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640776538  32 SNRGLTNVPKDLPLQT--TILNTSQNSISELqTSDISSLAKLRTLILSYNRIQHLNISVFKFnQKLEYLDLSHNELGKIS 109
Cdd:COG4886  144 SNNQLTDLPEPLGNLTnlKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLPEPLGNL-TNLEELDLSGNQLTDLP 221

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 640776538 110 C--YSTVNFKHLDLSFNAFDALPicqEFGNMSQLKFLGLSATQLE 152
Cdd:COG4886  222 EplANLTNLETLDLSNNQLTDLP---ELGNLTNLEELDLSNNQLT 263
LRRCT smart00082
Leucine rich repeat C-terminal domain;
524-577 1.72e-07

Leucine rich repeat C-terminal domain;


:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 48.20  E-value: 1.72e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 640776538   524 NPFQCTCELREFVKNLGQvssEVLEGWPDSYKCDYPESYKGtPLKDFHVSQLSC 577
Cdd:smart00082   1 NPFICDCELRWLLRWLQA---NEHLQDPVDLRCASPSSLRG-PLLELLHSEFKC 50
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
636-779 9.77e-42

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 149.01  E-value: 9.77e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640776538   636 QFHAFVSYSGHDsnWVKNELLPNLEKEN--IQICLHERNFVPGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYF 713
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEKLrgYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 640776538   714 AHHNLFHEGSNNLILILLEPIPQYsIPSSYHKLKTLMvRRTYLEWPKEKSKHglFWANLRAAINIK 779
Cdd:smart00255  79 ALENALEEGGLRVIPIFYEVIPSD-VRKQPGKFRKVF-KKNYLKWPEDEKEQ--FWKKALYAVPSK 140
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 637-781 4.32e-25

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 102.44  E-value: 4.32e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640776538  637 FHAFVSYSGHDS-NWVKNELLPNLEKENIQICLHERNFVPGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYFAH 715
Cdd:pfam01582   1 YDVFLSFRGSDTrEWFVSHLLKELKQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDELVKIL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640776538  716 HNLFhEGSNNLILILLEPIPQY------SIPSSYHKLKTLMVRRTYLEWPKE----------KSKH--GLFWANLRAAIN 777
Cdd:pfam01582  81 ECAL-DLGQKVIPIFYEVDPSDvrkqtgSFGKAFKKHKKVLTEEKVLKWRGAlnevaniwhsKSVSdeSKFWKKIAYDIS 159


                  ....
gi 640776538  778 IKLM 781
Cdd:pfam01582 160 NKLN 163
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
352-526 3.32e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 75.36  E-value: 3.32e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640776538 352 YLDLSNNLLTDtVFESCGSLTDLETLTLQRNQLKELAKIVtmtKEMKSLQQLDISQNSVRY-NENGRNCswtKSLLRLNM 430
Cdd:COG4886  117 SLDLSGNQLTD-LPEELANLTNLKELDLSNNQLTDLPEPL---GNLTNLKSLDLSNNQLTDlPEELGNL---TNLKELDL 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640776538 431 SSNILTD--SVFRCLPpRIKVLDLHKNRISSIPKGITCLEALQELNVAFNSLTDLPGCGTLSSLLVLIIDHNSVShpSVD 508
Cdd:COG4886  190 SNNQITDlpEPLGNLT-NLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLT--DLP 266

                        170
                 ....*....|....*...
gi 640776538 509 FFQSCQKIRSIKAGNNPF 526
Cdd:COG4886  267 PLANLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
32-152 5.48e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 62.26  E-value: 5.48e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640776538  32 SNRGLTNVPKDLPLQT--TILNTSQNSISELqTSDISSLAKLRTLILSYNRIQHLNISVFKFnQKLEYLDLSHNELGKIS 109
Cdd:COG4886  144 SNNQLTDLPEPLGNLTnlKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLPEPLGNL-TNLEELDLSGNQLTDLP 221

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 640776538 110 C--YSTVNFKHLDLSFNAFDALPicqEFGNMSQLKFLGLSATQLE 152
Cdd:COG4886  222 EplANLTNLETLDLSNNQLTDLP---ELGNLTNLEELDLSNNQLT 263
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 346-560 3.19e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 57.55  E-value: 3.19e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640776538 346 QISPFLYLDLSNNLLTDTVFESCGSLTDLETLTLQRNQLKelAKIVTMTKEMKSLQQLDISQNSVRyNENGRNCSWTKSL 425
Cdd:PLN00113 234 GLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLS--GPIPPSIFSLQKLISLDLSDNSLS-GEIPELVIQLQNL 310

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640776538 426 LRLNMSSNILTDSVFRCLP--PRIKVLDLHKNRIS-SIPKGITCLEALQELNVAFNSLT-DLP-GCGTLSSLLVLIIDHN 500
Cdd:PLN00113 311 EILHLFSNNFTGKIPVALTslPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTgEIPeGLCSSGNLFKLILFSN 390

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 640776538 501 SVSHPSVDFFQSCQKIRSIKAGNNPFqcTCEL-REFVK----NLGQVSSEVLEGWPDSYKCDYPE 560
Cdd:PLN00113 391 SLEGEIPKSLGACRSLRRVRLQDNSF--SGELpSEFTKlplvYFLDISNNNLQGRINSRKWDMPS 453
LRRCT smart00082
Leucine rich repeat C-terminal domain;
524-577 1.72e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 48.20  E-value: 1.72e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 640776538   524 NPFQCTCELREFVKNLGQvssEVLEGWPDSYKCDYPESYKGtPLKDFHVSQLSC 577
Cdd:smart00082   1 NPFICDCELRWLLRWLQA---NEHLQDPVDLRCASPSSLRG-PLLELLHSEFKC 50
LRR_8 pfam13855
Leucine rich repeat;
70-124 5.34e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.13  E-value: 5.34e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 640776538   70 KLRTLILSYNRIQHLNISVFKFNQKLEYLDLSHNELGKISCYSTVNFK---HLDLSFN 124
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPslrYLDLSGN 59
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 26-445 7.20e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 49.85  E-value: 7.20e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640776538  26 EFLVDRSNRGLTNVPKDLPLQTTI--LNTSQNSISELQTSDISSLAKLRTLILSYNRIQHLNISVFKFNQKLEYLDLSHN 103
Cdd:PLN00113 191 EFLTLASNQLVGQIPRELGQMKSLkwIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQN 270

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640776538 104 EL-GKI--SCYSTVNFKHLDLSFNAFDAlPICQEFGNMSQLKFLGLSATQLEKSRVLPIAHLNISKVLLVLGDFYGGkED 180
Cdd:PLN00113 271 KLsGPIppSIFSLQKLISLDLSDNSLSG-EIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSG-EI 348

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640776538 181 PQSLQDFNTESlhivfptkkefhfILDLSVrsvvslelSNIKCVLDDNECS--------YFPNALTKlQMNPRLTNL-TL 251
Cdd:PLN00113 349 PKNLGKHNNLT-------------VLDLST--------NNLTGEIPEGLCSsgnlfkliLFSNSLEG-EIPKSLGACrSL 406

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640776538 252 NNIETTWNSFIG-------ILQLVWnttieYFSISNVKLQGQLNSGDFNYSGTSIKALSIHQVVSDVfsfPQSHIYKIFS 324
Cdd:PLN00113 407 RRVRLQDNSFSGelpseftKLPLVY-----FLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFGGL---PDSFGSKRLE 478

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640776538 325 NMNIEYFTVSGTRMIHMLCPSQIspfLYLDLSNNLLTDTVFESCGSLTDLETLTLQRNQLKelAKIVTMTKEMKSLQQLD 404
Cdd:PLN00113 479 NLDLSRNQFSGAVPRKLGSLSEL---MQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLS--GQIPASFSEMPVLSQLD 553

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|.
gi 640776538 405 ISQNSVRyNENGRNCSWTKSLLRLNMSSNILTDSvfrcLPP 445
Cdd:PLN00113 554 LSQNQLS-GEIPKNLGNVESLVQVNISHNHLHGS----LPS 589
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
1-130 1.67e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 48.54  E-value: 1.67e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640776538   1 MTNIFHFII--IFTLILEIRAQLSYESEF------LVDRSNRgLTNVPKDLPLQTTILNTSQNSISELQTSDISSlakLR 72
Cdd:PRK15370 190 LTTIPACIPeqITTLILDNNELKSLPENLqgniktLYANSNQ-LTSIPATLPDTIQEMELSINRITELPERLPSA---LQ 265

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 640776538  73 TLILSYNRIQHLNISVfkfNQKLEYLDLSHNELGKISCYSTVNFKHLDLSFNAFDALP 130
Cdd:PRK15370 266 SLDLFHNKISCLPENL---PEELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTALP 320
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 351-526 2.54e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 43.24  E-value: 2.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640776538 351 LYLdLSNNLltdTVFESCGSLTDLETLTLQRNQLKELAKIVTMtkemKSLQQLDISQNSVRYNENGRNCSwtkSLLRLNM 430
Cdd:cd21340   29 LYL-YDNKI---TKIENLEFLTNLTHLYLQNNQIEKIENLENL----VNLKKLYLGGNRISVVEGLENLT---NLEELHI 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640776538 431 SSNILTDSVFRCLPPRIkvldlhknrISSIpkgitcLEALQELNVAFNSLTDLPGCGTLSSLLVLIIDHNSVSHPS--VD 508
Cdd:cd21340   98 ENQRLPPGEKLTFDPRS---------LAAL------SNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEelLD 162

                        170
                 ....*....|....*...
gi 640776538 509 FFQSCQKIRSIKAGNNPF 526
Cdd:cd21340  163 LLSSWPSLRELDLTGNPV 180
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 48-111 3.49e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.77  E-value: 3.49e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 640776538  48 TILNTSQNSISELqtSDISSLAKLRTLILSYNRIQHLN--ISVFKFNQKLEYLDLSHNELGKISCY 111
Cdd:cd21340  123 RVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDLTGNPVCKKPKY 186
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
636-779 9.77e-42

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 149.01  E-value: 9.77e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640776538   636 QFHAFVSYSGHDsnWVKNELLPNLEKEN--IQICLHERNFVPGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYF 713
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEKLrgYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 640776538   714 AHHNLFHEGSNNLILILLEPIPQYsIPSSYHKLKTLMvRRTYLEWPKEKSKHglFWANLRAAINIK 779
Cdd:smart00255  79 ALENALEEGGLRVIPIFYEVIPSD-VRKQPGKFRKVF-KKNYLKWPEDEKEQ--FWKKALYAVPSK 140
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 637-781 4.32e-25

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 102.44  E-value: 4.32e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640776538  637 FHAFVSYSGHDS-NWVKNELLPNLEKENIQICLHERNFVPGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYFAH 715
Cdd:pfam01582   1 YDVFLSFRGSDTrEWFVSHLLKELKQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDELVKIL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640776538  716 HNLFhEGSNNLILILLEPIPQY------SIPSSYHKLKTLMVRRTYLEWPKE----------KSKH--GLFWANLRAAIN 777
Cdd:pfam01582  81 ECAL-DLGQKVIPIFYEVDPSDvrkqtgSFGKAFKKHKKVLTEEKVLKWRGAlnevaniwhsKSVSdeSKFWKKIAYDIS 159


                  ....
gi 640776538  778 IKLM 781
Cdd:pfam01582 160 NKLN 163
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
 640-733 8.86e-17

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 76.97  E-value: 8.86e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640776538  640 FVSYSGHDSNWVKnELLPNLEKENIQICLHERNFVPGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHnlF 719
Cdd:pfam13676   2 FISYAGEDRAWAE-WLADALEAAGYRVWLDRWDIRPGDDWVEEIEEAIENSDRVLVVLSPNYLESPWCRAEWEAALA--D 78

                          90
                  ....*....|....
gi 640776538  720 HEGSNNLILILLEP 733
Cdd:pfam13676  79 PEGRKRLIPVRLEC 92
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
352-526 3.32e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 75.36  E-value: 3.32e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640776538 352 YLDLSNNLLTDtVFESCGSLTDLETLTLQRNQLKELAKIVtmtKEMKSLQQLDISQNSVRY-NENGRNCswtKSLLRLNM 430
Cdd:COG4886  117 SLDLSGNQLTD-LPEELANLTNLKELDLSNNQLTDLPEPL---GNLTNLKSLDLSNNQLTDlPEELGNL---TNLKELDL 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640776538 431 SSNILTD--SVFRCLPpRIKVLDLHKNRISSIPKGITCLEALQELNVAFNSLTDLPGCGTLSSLLVLIIDHNSVShpSVD 508
Cdd:COG4886  190 SNNQITDlpEPLGNLT-NLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLT--DLP 266

                        170
                 ....*....|....*...
gi 640776538 509 FFQSCQKIRSIKAGNNPF 526
Cdd:COG4886  267 PLANLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
235-541 5.00e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.97  E-value: 5.00e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640776538 235 NALTKLQMNPRLTNLTLNNIETTWNSFIGILQLVWNTTIEYFSISNVKLQGQLNSGDFNYSGTSIKALSIHQVVSdVFSF 314
Cdd:COG4886   23 TLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTN-LTEL 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640776538 315 PQSHIYKIFSNMNIEYFTVSGTRMIHMlcPSQISPFL---YLDLSNNLLTDtVFESCGSLTDLETLTLQRNQLKELAKIV 391
Cdd:COG4886  102 DLSGNEELSNLTNLESLDLSGNQLTDL--PEELANLTnlkELDLSNNQLTD-LPEPLGNLTNLKSLDLSNNQLTDLPEEL 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640776538 392 tmtKEMKSLQQLDISQNSVryNENGRNCSWTKSLLRLNMSSNILTD---SVFRClpPRIKVLDLHKNRISSIPkGITCLE 468
Cdd:COG4886  179 ---GNLTNLKELDLSNNQI--TDLPEPLGNLTNLEELDLSGNQLTDlpePLANL--TNLETLDLSNNQLTDLP-ELGNLT 250

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 640776538 469 ALQELNVAFNSLTDLPGCGTLSSLLVLIIDHNSVSHPSVDFFQSCQKIRSIKAGNNPFQCTCELREFVKNLGQ 541
Cdd:COG4886  251 NLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTL 323
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
32-152 5.48e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 62.26  E-value: 5.48e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640776538  32 SNRGLTNVPKDLPLQT--TILNTSQNSISELqTSDISSLAKLRTLILSYNRIQHLNISVFKFnQKLEYLDLSHNELGKIS 109
Cdd:COG4886  144 SNNQLTDLPEPLGNLTnlKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLPEPLGNL-TNLEELDLSGNQLTDLP 221

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 640776538 110 C--YSTVNFKHLDLSFNAFDALPicqEFGNMSQLKFLGLSATQLE 152
Cdd:COG4886  222 EplANLTNLETLDLSNNQLTDLP---ELGNLTNLEELDLSNNQLT 263
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
48-152 3.62e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 59.56  E-value: 3.62e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640776538  48 TILNTSQNSISELqTSDISSLAKLRTLILSYNRIQHLNiSVFKFNQKLEYLDLSHNELGKISC--YSTVNFKHLDLSFNA 125
Cdd:COG4886  116 ESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPEelGNLTNLKELDLSNNQ 193

                         90       100
                 ....*....|....*....|....*..
gi 640776538 126 FDALPicQEFGNMSQLKFLGLSATQLE 152
Cdd:COG4886  194 ITDLP--EPLGNLTNLEELDLSGNQLT 218
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
32-274 2.42e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 57.25  E-value: 2.42e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640776538  32 SNRGLTNVPKDL-PLQT-TILNTSQNSISELQTSdISSLAKLRTLILSYNRIQHLNISVFKFNqKLEYLDLSHNELGKIS 109
Cdd:COG4886  167 SNNQLTDLPEELgNLTNlKELDLSNNQITDLPEP-LGNLTNLEELDLSGNQLTDLPEPLANLT-NLETLDLSNNQLTDLP 244

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640776538 110 CYST-VNFKHLDLSFNAFDALPicqEFGNMSQLKFLGLSATQLEKSRVLPIAHLNISKVLLVLGDFYGGKEDPQSLQDFN 188
Cdd:COG4886  245 ELGNlTNLEELDLSNNQLTDLP---PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLT 321

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640776538 189 T---ESLHIVFPTKKEFHFILDLSVRSVVSLELSNIKCVLDDNECSYFPNALTKLQMNPRLTNLTLNNIETTWNSFIGIL 265
Cdd:COG4886  322 TlllLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVL 401


                 ....*....
gi 640776538 266 QLVWNTTIE 274
Cdd:COG4886  402 LLTLALLDA 410
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 346-560 3.19e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 57.55  E-value: 3.19e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640776538 346 QISPFLYLDLSNNLLTDTVFESCGSLTDLETLTLQRNQLKelAKIVTMTKEMKSLQQLDISQNSVRyNENGRNCSWTKSL 425
Cdd:PLN00113 234 GLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLS--GPIPPSIFSLQKLISLDLSDNSLS-GEIPELVIQLQNL 310

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640776538 426 LRLNMSSNILTDSVFRCLP--PRIKVLDLHKNRIS-SIPKGITCLEALQELNVAFNSLT-DLP-GCGTLSSLLVLIIDHN 500
Cdd:PLN00113 311 EILHLFSNNFTGKIPVALTslPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTgEIPeGLCSSGNLFKLILFSN 390

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 640776538 501 SVSHPSVDFFQSCQKIRSIKAGNNPFqcTCEL-REFVK----NLGQVSSEVLEGWPDSYKCDYPE 560
Cdd:PLN00113 391 SLEGEIPKSLGACRSLRRVRLQDNSF--SGELpSEFTKlplvYFLDISNNNLQGRINSRKWDMPS 453
LRRCT smart00082
Leucine rich repeat C-terminal domain;
524-577 1.72e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 48.20  E-value: 1.72e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 640776538   524 NPFQCTCELREFVKNLGQvssEVLEGWPDSYKCDYPESYKGtPLKDFHVSQLSC 577
Cdd:smart00082   1 NPFICDCELRWLLRWLQA---NEHLQDPVDLRCASPSSLRG-PLLELLHSEFKC 50
LRR_8 pfam13855
Leucine rich repeat;
70-124 5.34e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.13  E-value: 5.34e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 640776538   70 KLRTLILSYNRIQHLNISVFKFNQKLEYLDLSHNELGKISCYSTVNFK---HLDLSFN 124
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPslrYLDLSGN 59
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
328-484 1.61e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 51.62  E-value: 1.61e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640776538 328 IEYFTVSGTRMIHMlcPSQI-SPFLYLDLSNNLLT---DTVFEscgsltDLETLTLQRNQLKELAKIVTmtkemKSLQQL 403
Cdd:PRK15370 243 IQEMELSINRITEL--PERLpSALQSLDLFHNKISclpENLPE------ELRYLSVYDNSIRTLPAHLP-----SGITHL 309

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640776538 404 DISQNSVrynengrncSWTKSLLRLNMSSNILTDSVFRCLP----PRIKVLDLHKNRISSIPKgiTCLEALQELNVAFNS 479
Cdd:PRK15370 310 NVQSNSL---------TALPETLPPGLKTLEAGENALTSLPaslpPELQVLDVSKNQITVLPE--TLPPTITTLDVSRNA 378


                 ....*
gi 640776538 480 LTDLP 484
Cdd:PRK15370 379 LTNLP 383
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
8-152 1.70e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 51.09  E-value: 1.70e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640776538   8 IIIFTLILEIRAQLSYESEFLVDRSNRGLTNVPKDLPLQTTILNTSQNSISELQTSD------ISSLAKLRTLILSYNRI 81
Cdd:COG4886   46 LLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDlsgneeLSNLTNLESLDLSGNQL 125

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 640776538  82 QHLNISVFKFnQKLEYLDLSHNELGKI--SCYSTVNFKHLDLSFNAFDALPicQEFGNMSQLKFLGLSATQLE 152
Cdd:COG4886  126 TDLPEELANL-TNLKELDLSNNQLTDLpePLGNLTNLKSLDLSNNQLTDLP--EELGNLTNLKELDLSNNQIT 195
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 26-445 7.20e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 49.85  E-value: 7.20e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640776538  26 EFLVDRSNRGLTNVPKDLPLQTTI--LNTSQNSISELQTSDISSLAKLRTLILSYNRIQHLNISVFKFNQKLEYLDLSHN 103
Cdd:PLN00113 191 EFLTLASNQLVGQIPRELGQMKSLkwIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQN 270

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640776538 104 EL-GKI--SCYSTVNFKHLDLSFNAFDAlPICQEFGNMSQLKFLGLSATQLEKSRVLPIAHLNISKVLLVLGDFYGGkED 180
Cdd:PLN00113 271 KLsGPIppSIFSLQKLISLDLSDNSLSG-EIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSG-EI 348

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640776538 181 PQSLQDFNTESlhivfptkkefhfILDLSVrsvvslelSNIKCVLDDNECS--------YFPNALTKlQMNPRLTNL-TL 251
Cdd:PLN00113 349 PKNLGKHNNLT-------------VLDLST--------NNLTGEIPEGLCSsgnlfkliLFSNSLEG-EIPKSLGACrSL 406

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640776538 252 NNIETTWNSFIG-------ILQLVWnttieYFSISNVKLQGQLNSGDFNYSGTSIKALSIHQVVSDVfsfPQSHIYKIFS 324
Cdd:PLN00113 407 RRVRLQDNSFSGelpseftKLPLVY-----FLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFGGL---PDSFGSKRLE 478

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640776538 325 NMNIEYFTVSGTRMIHMLCPSQIspfLYLDLSNNLLTDTVFESCGSLTDLETLTLQRNQLKelAKIVTMTKEMKSLQQLD 404
Cdd:PLN00113 479 NLDLSRNQFSGAVPRKLGSLSEL---MQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLS--GQIPASFSEMPVLSQLD 553

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|.
gi 640776538 405 ISQNSVRyNENGRNCSWTKSLLRLNMSSNILTDSvfrcLPP 445
Cdd:PLN00113 554 LSQNQLS-GEIPKNLGNVESLVQVNISHNHLHGS----LPS 589
LRR_8 pfam13855
Leucine rich repeat;
48-105 1.21e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.28  E-value: 1.21e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 640776538   48 TILNTSQNSISELQTSDISSLAKLRTLILSYNRIQHLNISVFKFNQKLEYLDLSHNEL 105
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
1-130 1.67e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 48.54  E-value: 1.67e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640776538   1 MTNIFHFII--IFTLILEIRAQLSYESEF------LVDRSNRgLTNVPKDLPLQTTILNTSQNSISELQTSDISSlakLR 72
Cdd:PRK15370 190 LTTIPACIPeqITTLILDNNELKSLPENLqgniktLYANSNQ-LTSIPATLPDTIQEMELSINRITELPERLPSA---LQ 265

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 640776538  73 TLILSYNRIQHLNISVfkfNQKLEYLDLSHNELGKISCYSTVNFKHLDLSFNAFDALP 130
Cdd:PRK15370 266 SLDLFHNKISCLPENL---PEELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTALP 320
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
2-152 3.13e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 47.24  E-value: 3.13e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640776538   2 TNIFHFIIIFTLILEIRAQLSYESEFLVDRSNRGLTNVPKDLPLQTTILNTSQNSISELQTSDISSLAKLRTLILSYNR- 80
Cdd:COG4886   29 LLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEe 108

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 640776538  81 IQHLnisvfkfnQKLEYLDLSHNELGKI--SCYSTVNFKHLDLSFNAFDALPicQEFGNMSQLKFLGLSATQLE 152
Cdd:COG4886  109 LSNL--------TNLESLDLSGNQLTDLpeELANLTNLKELDLSNNQLTDLP--EPLGNLTNLKSLDLSNNQLT 172
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 351-526 2.54e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 43.24  E-value: 2.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640776538 351 LYLdLSNNLltdTVFESCGSLTDLETLTLQRNQLKELAKIVTMtkemKSLQQLDISQNSVRYNENGRNCSwtkSLLRLNM 430
Cdd:cd21340   29 LYL-YDNKI---TKIENLEFLTNLTHLYLQNNQIEKIENLENL----VNLKKLYLGGNRISVVEGLENLT---NLEELHI 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640776538 431 SSNILTDSVFRCLPPRIkvldlhknrISSIpkgitcLEALQELNVAFNSLTDLPGCGTLSSLLVLIIDHNSVSHPS--VD 508
Cdd:cd21340   98 ENQRLPPGEKLTFDPRS---------LAAL------SNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEelLD 162

                        170
                 ....*....|....*...
gi 640776538 509 FFQSCQKIRSIKAGNNPF 526
Cdd:cd21340  163 LLSSWPSLRELDLTGNPV 180
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 352-493 3.54e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.50  E-value: 3.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640776538 352 YLDLSNNLLTDT---VFESCGSLTDLETLTLQRNQL-----KELAKIVTMTKEmkSLQQLDISQNSVryneNGRNCSWTK 423
Cdd:cd00116   85 ELDLSDNALGPDgcgVLESLLRSSSLQELKLNNNGLgdrglRLLAKGLKDLPP--ALEKLVLGRNRL----EGASCEALA 158

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640776538 424 SLLR-------LNMSSNILTDSVFRCLPP------RIKVLDLHKNRISSIPKGITC-----LEALQELNVAFNSLTDLPG 485
Cdd:cd00116  159 KALRanrdlkeLNLANNGIGDAGIRALAEglkancNLEVLDLNNNGLTDEGASALAetlasLKSLEVLNLGDNNLTDAGA 238


                 ....*...
gi 640776538 486 CGTLSSLL 493
Cdd:cd00116  239 AALASALL 246
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 48-526 4.04e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.07  E-value: 4.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640776538  48 TILNTSQNSISELQTSDISSLAKLRTLILSYNRIQ-HLNISVFKFNQKLEYLDLSHNEL-GKISCYSTVNFKHLDLSFNA 125
Cdd:PLN00113  72 VSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFtGSIPRGSIPNLETLDLSNNM 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640776538 126 FDAlPICQEFGNMSQLKFLGLSATQLEKSrvLPIAHLNISkvllvlgdfyggkedpqSLQDFNTESLHIVFPTKKEFHfi 205
Cdd:PLN00113 152 LSG-EIPNDIGSFSSLKVLDLGGNVLVGK--IPNSLTNLT-----------------SLEFLTLASNQLVGQIPRELG-- 209

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640776538 206 ldlsvrsvvslELSNIKCV-LDDNECS-YFPNALTKLQmnprltnlTLNNIETTWNSFIG-ILQLVWN-TTIEYFSISNV 281
Cdd:PLN00113 210 -----------QMKSLKWIyLGYNNLSgEIPYEIGGLT--------SLNHLDLVYNNLTGpIPSSLGNlKNLQYLFLYQN 270

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640776538 282 KLQGQ-------------LNSGDFNYSG------TSIKALSIHQVVSDVF---------SFPQSHIYKIFSN-------- 325
Cdd:PLN00113 271 KLSGPippsifslqklisLDLSDNSLSGeipelvIQLQNLEILHLFSNNFtgkipvaltSLPRLQVLQLWSNkfsgeipk 350

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640776538 326 ----------MNIEYFTVSGtRMIHMLCPSqiSPFLYLDLSNNLLTDTVFESCGSLTDLETLTLQRNQLK-ELAKIVTmt 394
Cdd:PLN00113 351 nlgkhnnltvLDLSTNNLTG-EIPEGLCSS--GNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSgELPSEFT-- 425

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640776538 395 kEMKSLQQLDISQNSVRYNENGRNCSWTkSLLRLNMSSNiltdSVFRCLP-----PRIKVLDLHKNRIS-SIPKGITCLE 468
Cdd:PLN00113 426 -KLPLVYFLDISNNNLQGRINSRKWDMP-SLQMLSLARN----KFFGGLPdsfgsKRLENLDLSRNQFSgAVPRKLGSLS 499

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 640776538 469 ALQELNVAFNSLT-DLPgcgtlssllvliidhnsvshpsvDFFQSCQKIRSIKAGNNPF 526
Cdd:PLN00113 500 ELMQLKLSENKLSgEIP-----------------------DELSSCKKLVSLDLSHNQL 535
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 43-546 4.87e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 43.68  E-value: 4.87e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640776538  43 LPLQTTIlNTSQNSISELQTSDISSLA-KLRTLILSYNRIQHLNISVFKFNqkLEYLDLSHNEL-GKI--SCYSTVNFKH 118
Cdd:PLN00113  92 LPYIQTI-NLSNNQLSGPIPDDIFTTSsSLRYLNLSNNNFTGSIPRGSIPN--LETLDLSNNMLsGEIpnDIGSFSSLKV 168

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640776538 119 LDLSFNAFDAlPICQEFGNMSQLKFLGLSATQ--------LEKSRVLPIAHL---NISKVL--------------LVLGD 173
Cdd:PLN00113 169 LDLGGNVLVG-KIPNSLTNLTSLEFLTLASNQlvgqipreLGQMKSLKWIYLgynNLSGEIpyeiggltslnhldLVYNN 247

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640776538 174 FYGgkEDPQSLQDFNteSLHIVFPTKKEFHFILDLSV---RSVVSLELSnikcvldDNECS-YFPNALTKLQmnprltnl 249
Cdd:PLN00113 248 LTG--PIPSSLGNLK--NLQYLFLYQNKLSGPIPPSIfslQKLISLDLS-------DNSLSgEIPELVIQLQ-------- 308

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640776538 250 tlnNIEttwnsfigILQLVWNttieyfsisnvKLQGQLNSGDfnysgTSIKALSIHQVVSDVFS--FPQS-HIYKIFSNM 326
Cdd:PLN00113 309 ---NLE--------ILHLFSN-----------NFTGKIPVAL-----TSLPRLQVLQLWSNKFSgeIPKNlGKHNNLTVL 361

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640776538 327 NIEYFTVSGtRMIHMLCPSqiSPFLYLDLSNNLLTDTVFESCGSLTDLETLTLQRNQLK-ELAKIVTmtkEMKSLQQLDI 405
Cdd:PLN00113 362 DLSTNNLTG-EIPEGLCSS--GNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSgELPSEFT---KLPLVYFLDI 435

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640776538 406 SQNSVRYNENGRNCSWTkSLLRLNMSSNiltdSVFRCLP-----PRIKVLDLHKNRIS-SIPKGITCLEALQELNVAFNS 479
Cdd:PLN00113 436 SNNNLQGRINSRKWDMP-SLQMLSLARN----KFFGGLPdsfgsKRLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENK 510

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 640776538 480 LT-----DLPGCGTLSSllvLIIDHNSVSHPSVDFFQSCQKIRSIKAGNNPFQctcelREFVKNLGQVSSEV 546
Cdd:PLN00113 511 LSgeipdELSSCKKLVS---LDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLS-----GEIPKNLGNVESLV 574
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 353-474 1.52e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 41.57  E-value: 1.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640776538 353 LDLSNNLLTD----TVFESCGSLTDLETLTLQRNQLKEL-AKIVTMT-KEMKSLQQLDISQNSVRynENG------RNCS 420
Cdd:cd00116  170 LNLANNGIGDagirALAEGLKANCNLEVLDLNNNGLTDEgASALAETlASLKSLEVLNLGDNNLT--DAGaaalasALLS 247

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 640776538 421 WTKSLLRLNMSSNILTDSVFRCL------PPRIKVLDLHKNRISSIPKGITCLEALQELN 474
Cdd:cd00116  248 PNISLLTLSLSCNDITDDGAKDLaevlaeKESLLELDLRGNKFGEEGAQLLAESLLEPGN 307
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 352-415 1.56e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.92  E-value: 1.56e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 640776538 352 YLDLSNNLLTDTvfESCGSLTDLETLTLQRNQLKELAKIVTMTKEMKSLQQLDISQNSV----RYNEN 415
Cdd:cd21340  124 VLNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEELLDLLSSWPSLRELDLTGNPVckkpKYRDK 189
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 48-111 3.49e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.77  E-value: 3.49e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 640776538  48 TILNTSQNSISELqtSDISSLAKLRTLILSYNRIQHLN--ISVFKFNQKLEYLDLSHNELGKISCY 111
Cdd:cd21340  123 RVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDLTGNPVCKKPKY 186
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 352-500 4.34e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.60  E-value: 4.34e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640776538 352 YLDLSNNLLTDTVFESCGSLTDLETLTLQRNQ-LKELAKivtmTKEMKSLQQLDISQNSVRYNENGRNCSWTKsLLRLNM 430
Cdd:PLN00113 432 FLDISNNNLQGRINSRKWDMPSLQMLSLARNKfFGGLPD----SFGSKRLENLDLSRNQFSGAVPRKLGSLSE-LMQLKL 506

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 640776538 431 SSNILTDSVFRCLPPRIKV--LDLHKNRIS-SIPKGITCLEALQELNVAFNSLT-DLP-GCGTLSSLLVLIIDHN 500
Cdd:PLN00113 507 SENKLSGEIPDELSSCKKLvsLDLSHNQLSgQIPASFSEMPVLSQLDLSQNQLSgEIPkNLGNVESLVQVNISHN 581
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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