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Conserved domains on  [gi|688548033|ref|XP_009298590|]
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ethanolamine kinase 1 isoform X3 [Danio rerio]

Protein Classification

protein kinase family protein( domain architecture ID 229378)

protein kinase family protein may catalyze the transfer of the gamma-phosphoryl group from ATP to substrates such as serine/threonine and/or tyrosine residues on proteins, or may be a pseudokinase

CATH:  1.10.510.10
PubMed:  16244704
SCOP:  4003661

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PKc_like super family cl21453
Protein Kinases, catalytic domain; The protein kinase superfamily is mainly composed of the ...
 46-231 1.34e-71

Protein Kinases, catalytic domain; The protein kinase superfamily is mainly composed of the catalytic domains of serine/threonine-specific and tyrosine-specific protein kinases. It also includes RIO kinases, which are atypical serine protein kinases, aminoglycoside phosphotransferases, and choline kinases. These proteins catalyze the transfer of the gamma-phosphoryl group from ATP to hydroxyl groups in specific substrates such as serine, threonine, or tyrosine residues of proteins.


The actual alignment was detected with superfamily member cd05157:

Pssm-ID: 473864 [Multi-domain]  Cd Length: 307  Bit Score: 221.69  E-value: 1.34e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688548033  46 VKMKTFTDGITNKLIGCYVGGSMQ-EVVLVRVYGNKTELFVDRENEVKSFRVLQAHRCAPRLYCTFNNGLCYEFLQGVAL 124
Cdd:cd05157    1 IKVKRITGGITNALYKVTYPSGDTpKTVLVRIYGPGTELLIDRDRELRILQLLSRAGIGPKLYGRFENGRVEEFLPGRTL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688548033 125 EPEHIRSPAIFRHIARQMAKYHAIHAHNGWV--PQSGLWLKMSKFFSLVPSHFEDPEMDQRlNNEVPSAACLRDEMIWLQ 202
Cdd:cd05157   81 TPEDLRDPKISRLIARRLAELHSIVPLGEIEgkKKPILWTTIRKWLDLAPEVFEDEKNKEK-KLEKVDLERLRKELEWLE 159

                        170       180       190
                 ....*....|....*....|....*....|
gi 688548033 203 QNLSKL-GSPVVLCHNDLLCKNIIYNQKED 231
Cdd:cd05157  160 KWLESLeKSPIVFCHNDLLYGNILYNEDDD 189
 
Name Accession Description Interval E-value
ETNK_euk cd05157
Euykaryotic Ethanolamine kinase; ETNK catalyzes the transfer of the gamma-phosphoryl group ...
 46-231 1.34e-71

Euykaryotic Ethanolamine kinase; ETNK catalyzes the transfer of the gamma-phosphoryl group from CTP to ethanolamine (Etn), the first step in the CDP-Etn pathway for the formation of the major phospholipid, phosphatidylethanolamine (PtdEtn). Unlike ChoK, ETNK shows specific activity for its substrate, and displays negligible activity towards N-methylated derivatives of Etn. The Drosophila ETNK is implicated in development and neuronal function. Mammals contain two ETNK proteins, ETNK1 and ETNK2. ETNK1 selectively increases Etn uptake and phosphorylation, as well as PtdEtn synthesis. ETNK2 is found primarily in the liver and reproductive tissues. It plays a critical role in regulating placental hemostasis to support late embryonic development. It may also have a role in testicular maturation. ETNK is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 270706 [Multi-domain]  Cd Length: 307  Bit Score: 221.69  E-value: 1.34e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688548033  46 VKMKTFTDGITNKLIGCYVGGSMQ-EVVLVRVYGNKTELFVDRENEVKSFRVLQAHRCAPRLYCTFNNGLCYEFLQGVAL 124
Cdd:cd05157    1 IKVKRITGGITNALYKVTYPSGDTpKTVLVRIYGPGTELLIDRDRELRILQLLSRAGIGPKLYGRFENGRVEEFLPGRTL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688548033 125 EPEHIRSPAIFRHIARQMAKYHAIHAHNGWV--PQSGLWLKMSKFFSLVPSHFEDPEMDQRlNNEVPSAACLRDEMIWLQ 202
Cdd:cd05157   81 TPEDLRDPKISRLIARRLAELHSIVPLGEIEgkKKPILWTTIRKWLDLAPEVFEDEKNKEK-KLEKVDLERLRKELEWLE 159

                        170       180       190
                 ....*....|....*....|....*....|
gi 688548033 203 QNLSKL-GSPVVLCHNDLLCKNIIYNQKED 231
Cdd:cd05157  160 KWLESLeKSPIVFCHNDLLYGNILYNEDDD 189
Choline_kinase pfam01633
Choline/ethanolamine kinase; Choline kinase catalyzes the committed step in the synthesis of ...
 69-231 6.48e-54

Choline/ethanolamine kinase; Choline kinase catalyzes the committed step in the synthesis of phosphatidylcholine by the CDP-choline pathway. This alignment covers the protein kinase portion of the protein. The divergence of this family makes it very difficult to create a model that specifically predicts choline/ethanolamine kinases only. However if [add Pfam ID here for Choline_kinase_C] is also present then it is definitely a member of this family.


Pssm-ID: 396278 [Multi-domain]  Cd Length: 211  Bit Score: 173.23  E-value: 6.48e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688548033   69 QEVVLVRVYGNKTELFVDRENEVKSFRVLQAHRCAPRLYCTFNNGLCYEFLQGVALEPEHIRSPAIFRHIARQMAKYHAI 148
Cdd:pfam01633   2 PRKVLLRIYGPGTELLINREDEIVNFALLSERGLGPKLYGFFPNGRIEEFIPSRTLSTEDLRDPEISKLIAKRLAELHSL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688548033  149 HAHngWVPQSGLWLKMSKFFSLVPSHFEDPEMDQRLNNEVPSAACLRDEMIWLQQNLSKLGSPVVLCHNDLLCKNIIYNQ 228
Cdd:pfam01633  82 EMP--GKKSPSLWKTMRKWLSLLKNLGAPESVNKSEQLKSINLEDLEKEINKLEKWLELLDSPIVFCHNDLQSGNILLLN 159


                  ...
gi 688548033  229 KED 231
Cdd:pfam01633 160 ETK 162
PLN02421 PLN02421
phosphotransferase, alcohol group as acceptor/kinase
 33-231 3.15e-28

phosphotransferase, alcohol group as acceptor/kinase


Pssm-ID: 215231 [Multi-domain]  Cd Length: 330  Bit Score: 109.83  E-value: 3.15e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688548033  33 LIKTLRPHWK---PSEVKMKTFTDGITNKLIGCYVGG--SMQEVVLVRVYGNKTELFVDRENEVKSFRVLQAHRCAPRLY 107
Cdd:PLN02421   1 VCKALFKGWSdldDSDFSVERISGGITNLLLKVSVKEenGNEVSVTVRLFGPNTDYVIDRERELQAIKYLSAAGFGAKLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688548033 108 CTFNNGLCYEFLQGVALEPEHIRSPAIFRHIARQMAKYHAIHAHNGWVPQsgLWLKMSKFFSLVPS-HFEDPEMDQRLnn 186
Cdd:PLN02421  81 GVFGNGMIQSFINARTLTPSDMRKPKVAAEIAKELRRLHQVEIPGSKEPQ--LWNDIFKFYEKASTvKFEDPEKQKKY-- 156

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 688548033 187 EVPSAACLRDEMIWLQQNLSKLGSPVVLCHNDLLCKNIIYNQKED 231
Cdd:PLN02421 157 ETISFEELRDEIVELKEITDSLKAPVVFAHNDLLSGNLMLNEDEG 201
YcbJ COG3173
Predicted kinase, aminoglycoside phosphotransferase (APT) family [General function prediction ...
 72-230 3.79e-04

Predicted kinase, aminoglycoside phosphotransferase (APT) family [General function prediction only];


Pssm-ID: 442406 [Multi-domain]  Cd Length: 284  Bit Score: 40.87  E-value: 3.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688548033  72 VLVRVY--GNKTELFVDREnevksFRVLQA-HRCA----PRLYCTFNNG-------LCYEFLQGVALEPEHIR-SPAIFR 136
Cdd:COG3173   45 LVLRRPprGLASAHDVRRE-----ARVLRAlAPRLgvpvPRPLALGEDGevigapfYVMEWVEGETLEDALPDlSPAERR 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688548033 137 HIARQMAKYHA-IHAHNgwVPQSGLwlkmskfFSLVPSHFEDP------EMDQRLNNEVPSAACLRDEMIWLQQNLSKLG 209
Cdd:COG3173  120 ALARALGEFLAaLHAVD--PAAAGL-------ADGRPEGLERQlarwraQLRRALARTDDLPALRERLAAWLAANLPEWG 190

                        170       180
                 ....*....|....*....|.
gi 688548033 210 sPVVLCHNDLLCKNIIYNQKE 230
Cdd:COG3173  191 -PPVLVHGDLRPGNLLVDPDD 210
 
Name Accession Description Interval E-value
ETNK_euk cd05157
Euykaryotic Ethanolamine kinase; ETNK catalyzes the transfer of the gamma-phosphoryl group ...
 46-231 1.34e-71

Euykaryotic Ethanolamine kinase; ETNK catalyzes the transfer of the gamma-phosphoryl group from CTP to ethanolamine (Etn), the first step in the CDP-Etn pathway for the formation of the major phospholipid, phosphatidylethanolamine (PtdEtn). Unlike ChoK, ETNK shows specific activity for its substrate, and displays negligible activity towards N-methylated derivatives of Etn. The Drosophila ETNK is implicated in development and neuronal function. Mammals contain two ETNK proteins, ETNK1 and ETNK2. ETNK1 selectively increases Etn uptake and phosphorylation, as well as PtdEtn synthesis. ETNK2 is found primarily in the liver and reproductive tissues. It plays a critical role in regulating placental hemostasis to support late embryonic development. It may also have a role in testicular maturation. ETNK is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 270706 [Multi-domain]  Cd Length: 307  Bit Score: 221.69  E-value: 1.34e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688548033  46 VKMKTFTDGITNKLIGCYVGGSMQ-EVVLVRVYGNKTELFVDRENEVKSFRVLQAHRCAPRLYCTFNNGLCYEFLQGVAL 124
Cdd:cd05157    1 IKVKRITGGITNALYKVTYPSGDTpKTVLVRIYGPGTELLIDRDRELRILQLLSRAGIGPKLYGRFENGRVEEFLPGRTL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688548033 125 EPEHIRSPAIFRHIARQMAKYHAIHAHNGWV--PQSGLWLKMSKFFSLVPSHFEDPEMDQRlNNEVPSAACLRDEMIWLQ 202
Cdd:cd05157   81 TPEDLRDPKISRLIARRLAELHSIVPLGEIEgkKKPILWTTIRKWLDLAPEVFEDEKNKEK-KLEKVDLERLRKELEWLE 159

                        170       180       190
                 ....*....|....*....|....*....|
gi 688548033 203 QNLSKL-GSPVVLCHNDLLCKNIIYNQKED 231
Cdd:cd05157  160 KWLESLeKSPIVFCHNDLLYGNILYNEDDD 189
Choline_kinase pfam01633
Choline/ethanolamine kinase; Choline kinase catalyzes the committed step in the synthesis of ...
 69-231 6.48e-54

Choline/ethanolamine kinase; Choline kinase catalyzes the committed step in the synthesis of phosphatidylcholine by the CDP-choline pathway. This alignment covers the protein kinase portion of the protein. The divergence of this family makes it very difficult to create a model that specifically predicts choline/ethanolamine kinases only. However if [add Pfam ID here for Choline_kinase_C] is also present then it is definitely a member of this family.


Pssm-ID: 396278 [Multi-domain]  Cd Length: 211  Bit Score: 173.23  E-value: 6.48e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688548033   69 QEVVLVRVYGNKTELFVDRENEVKSFRVLQAHRCAPRLYCTFNNGLCYEFLQGVALEPEHIRSPAIFRHIARQMAKYHAI 148
Cdd:pfam01633   2 PRKVLLRIYGPGTELLINREDEIVNFALLSERGLGPKLYGFFPNGRIEEFIPSRTLSTEDLRDPEISKLIAKRLAELHSL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688548033  149 HAHngWVPQSGLWLKMSKFFSLVPSHFEDPEMDQRLNNEVPSAACLRDEMIWLQQNLSKLGSPVVLCHNDLLCKNIIYNQ 228
Cdd:pfam01633  82 EMP--GKKSPSLWKTMRKWLSLLKNLGAPESVNKSEQLKSINLEDLEKEINKLEKWLELLDSPIVFCHNDLQSGNILLLN 159


                  ...
gi 688548033  229 KED 231
Cdd:pfam01633 160 ETK 162
PLN02421 PLN02421
phosphotransferase, alcohol group as acceptor/kinase
 33-231 3.15e-28

phosphotransferase, alcohol group as acceptor/kinase


Pssm-ID: 215231 [Multi-domain]  Cd Length: 330  Bit Score: 109.83  E-value: 3.15e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688548033  33 LIKTLRPHWK---PSEVKMKTFTDGITNKLIGCYVGG--SMQEVVLVRVYGNKTELFVDRENEVKSFRVLQAHRCAPRLY 107
Cdd:PLN02421   1 VCKALFKGWSdldDSDFSVERISGGITNLLLKVSVKEenGNEVSVTVRLFGPNTDYVIDRERELQAIKYLSAAGFGAKLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688548033 108 CTFNNGLCYEFLQGVALEPEHIRSPAIFRHIARQMAKYHAIHAHNGWVPQsgLWLKMSKFFSLVPS-HFEDPEMDQRLnn 186
Cdd:PLN02421  81 GVFGNGMIQSFINARTLTPSDMRKPKVAAEIAKELRRLHQVEIPGSKEPQ--LWNDIFKFYEKASTvKFEDPEKQKKY-- 156

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 688548033 187 EVPSAACLRDEMIWLQQNLSKLGSPVVLCHNDLLCKNIIYNQKED 231
Cdd:PLN02421 157 ETISFEELRDEIVELKEITDSLKAPVVFAHNDLLSGNLMLNEDEG 201
ChoK_euk cd05156
Euykaryotic Choline Kinase; ChoK catalyzes the transfer of the gamma-phosphoryl group from ATP ...
 46-240 1.67e-18

Euykaryotic Choline Kinase; ChoK catalyzes the transfer of the gamma-phosphoryl group from ATP (or CTP) to its substrate, choline, producing phosphorylcholine (PCho), a precursor to the biosynthesis of two major membrane phospholipids, phosphatidylcholine (PC) and sphingomyelin (SM). Although choline is the preferred substrate, ChoK also shows substantial activity towards ethanolamine and its N-methylated derivatives. ChoK plays an important role in cell signaling pathways and the regulation of cell growth. Along with PCho, it is involved in malignant transformation through Ras oncogenes in various human cancers such as breast, lung, colon, prostate, neuroblastoma, and hepatic lymphoma. In mammalian cells, there are three ChoK isoforms (A-1, A-2, and B) which are active in homo- or heterodimeric forms. The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 270705 [Multi-domain]  Cd Length: 326  Bit Score: 83.06  E-value: 1.67e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688548033  46 VKMKTFTDGITNKLIGC------YVGGSMQEVVLVRVYGNKTELFVDRENEVKSFRVLQAHRCAPRLYCTFNNGLCYEFL 119
Cdd:cd05156    1 FGIKTITGGLSNLLYLCslpdgvVPVGGEPRKVLLRIYGQILQAEESLVTESVIFALLSERGLGPKLYGIFPGGRLEEFI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688548033 120 QGVALEPEHIRSPAIFRHIARQMAKYHAIHahngwVPQS----GLWLKMSKFFSLVPSH-FEDPEMDQRLNNEVPSAACL 194
Cdd:cd05156   81 PSRPLTTDELSLPEISRKIARKMARFHSLE-----MPISkepkWLFDTMERWLKEALSIlFTDEPTKPSKQLELLLSYDL 155

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 688548033 195 RDEMIWLQQNLSKLGSPVVLCHNDLLCKNIIYNQKEDVSLPKSLHL 240
Cdd:cd05156  156 AKELGWLRSLLESTPSPVVFCHNDLQEGNILLLNGPENSEDDKLVL 201
PLN02236 PLN02236
choline kinase
 72-232 5.39e-18

choline kinase


Pssm-ID: 177880 [Multi-domain]  Cd Length: 344  Bit Score: 82.01  E-value: 5.39e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688548033  72 VLVRVYGNKTELFVDRENEVKSFRVLQAHRCAPRLYCTFNNGLCYEFLQGVALEPEHIRSPAIFRHIARQMAKYHAIHah 151
Cdd:PLN02236  68 VLVRIYGEGVELFFDRDDEIRTFECMSRHGQGPRLLGRFPNGRVEEFIHARTLSAADLRDPEISALIAAKLREFHSLD-- 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688548033 152 ngwVPQSG---LWLKMSKFFSLVPSHFEDPEMDQ-RLNnevpsaaCLRDEMIWLQQNLSKLGSPVVLCHNDLLCKNIIYN 227
Cdd:PLN02236 146 ---MPGPKnvlLWDRLRNWLKEAKNLCSPEEAKEfRLD-------SLEDEINLLEKELSGDDQEIGFCHNDLQYGNIMID 215


                 ....*
gi 688548033 228 QKEDV 232
Cdd:PLN02236 216 EETRA 220
ChoK-like_euk cd14021
Euykaryotic Choline Kinase and similar proteins; This group is composed of eukaryotic choline ...
 49-231 5.42e-18

Euykaryotic Choline Kinase and similar proteins; This group is composed of eukaryotic choline kinase, ethanolamine kinase, and similar proteins. ChoK catalyzes the transfer of the gamma-phosphoryl group from ATP (or CTP) to its substrate, choline, producing phosphorylcholine (PCho), a precursor to the biosynthesis of two major membrane phospholipids, phosphatidylcholine (PC), and sphingomyelin (SM). Although choline is the preferred substrate, ChoK also shows substantial activity towards ethanolamine and its N-methylated derivatives. ETNK catalyzes the transfer of the gamma-phosphoryl group from CTP to ethanolamine (Etn), the first step in the CDP-Etn pathway for the formation of the major phospholipid, phosphatidylethanolamine (PtdEtn). Unlike ChoK, ETNK shows specific activity for its substrate and displays negligible activity towards N-methylated derivatives of Etn. ChoK plays an important role in cell signaling pathways and the regulation of cell growth. The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 270923 [Multi-domain]  Cd Length: 229  Bit Score: 80.39  E-value: 5.42e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688548033  49 KTFTDGITNKL----IGCYVGGSMQEVVLVRVYGNKTELFVDRENEVKSFRVLQAHRCAPRLYCTFNNGLCYEFLQGVAL 124
Cdd:cd14021    4 IRILSGLTNQVykvsLKDESDSLEPKKVLFRIYGKYLSTLYDREKESEVFKILSEQGLGPKLIYKFDGGRIEEYIDGRPL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688548033 125 EPEHIRSPAIFRHIARQMAKYHAIHAhngwvpqsglwlkmskffslvpshfedpemdqrlnnevpsaaclrdemiwlqqn 204
Cdd:cd14021   84 TTDELRNPSVLTSIAKLLAKFHKIKT------------------------------------------------------ 109

                        170       180
                 ....*....|....*....|....*..
gi 688548033 205 lsklgSPVVLCHNDLLCKNIIYNQKED 231
Cdd:cd14021  110 -----PPVVFCHNDLQENNILLTNDQD 131
PTZ00296 PTZ00296
choline kinase; Provisional
 40-229 8.90e-14

choline kinase; Provisional


Pssm-ID: 240350 [Multi-domain]  Cd Length: 442  Bit Score: 70.30  E-value: 8.90e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688548033  40 HWKPSEVKMKTFTDGITNKLIGCYVGGS-------MQEVVLVRVYGNKTELFVDRENEVKSFRVLQAHRCAPRLYCTFNN 112
Cdd:PTZ00296 102 RFTEDDVRVNQILSGLTNQLFEVSLKEEtannypsIRRRVLFRIYGKDVDELYNPISEFEVYKTMSKYRIAPQLLNTFSG 181

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688548033 113 GLCYEFLQGVALEPEHIRSPAIFRHIARQMAKYHAI----HAHNGWVPQSGLWLKMSKFFSLVpSHFEDPEMDQRLNNEV 188
Cdd:PTZ00296 182 GRIEEWLYGDPLRIDDLKNPSILIGIANVLGKFHTLsrkrHLPEHWDRTPCIFKMMEKWKNQL-SKYKNIEKYQRDIHKY 260

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 688548033 189 PSAACLRDEMIWLQQNLSKLGSPVVLCHNDLLCKNIIYNQK 229
Cdd:PTZ00296 261 IKESEKFIKFMKVYSKSDNLANDIVFCHNDLQENNIINTNK 301
ChoK-like cd05151
Choline Kinase and similar proteins; This subfamily is composed of bacterial and eukaryotic ...
 54-230 2.47e-12

Choline Kinase and similar proteins; This subfamily is composed of bacterial and eukaryotic choline kinases, as well as eukaryotic ethanolamine kinase. ChoK catalyzes the transfer of the gamma-phosphoryl group from ATP (or CTP) to its substrate, choline, producing phosphorylcholine (PCho), a precursor to the biosynthesis of two major membrane phospholipids, phosphatidylcholine (PC), and sphingomyelin (SM). Although choline is the preferred substrate, ChoK also shows substantial activity towards ethanolamine and its N-methylated derivatives. Bacterial ChoK is also referred to as licA protein. ETNK catalyzes the transfer of the gamma-phosphoryl group from CTP to ethanolamine (Etn), the first step in the CDP-Etn pathway for the formation of the major phospholipid, phosphatidylethanolamine (PtdEtn). Unlike ChoK, ETNK shows specific activity for its substrate and displays negligible activity towards N-methylated derivatives of Etn. ChoK plays an important role in cell signaling pathways and the regulation of cell growth. The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 270700 [Multi-domain]  Cd Length: 152  Bit Score: 62.96  E-value: 2.47e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688548033  54 GITNKLIGCYVGGsmqEVVLVRVYGNKTELFVDRENEVKSFRVLQAHRCAPR-LYCTFNNG-LCYEFLQGVALEPEHIRS 131
Cdd:cd05151    9 GLTNKNYLVEVAG---KKYVLRIPGAGTELLIDRENEKANSKAAAELGIAPEvIYFDPETGvKITEFIEGATLLTNDFSD 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688548033 132 PAIFRHIARQMAKYHAIHAHngwvpqsglwlkmskffslvpshfedpemdqrlnnevpsaaclrdemiwlqqnlsklgsP 211
Cdd:cd05151   86 PENLERIAALLRKLHSSPLE-----------------------------------------------------------D 106

                        170
                 ....*....|....*....
gi 688548033 212 VVLCHNDLLCKNIIYNQKE 230
Cdd:cd05151  107 LVLCHNDLVPGNFLLDDDR 125
YcbJ COG3173
Predicted kinase, aminoglycoside phosphotransferase (APT) family [General function prediction ...
 72-230 3.79e-04

Predicted kinase, aminoglycoside phosphotransferase (APT) family [General function prediction only];


Pssm-ID: 442406 [Multi-domain]  Cd Length: 284  Bit Score: 40.87  E-value: 3.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688548033  72 VLVRVY--GNKTELFVDREnevksFRVLQA-HRCA----PRLYCTFNNG-------LCYEFLQGVALEPEHIR-SPAIFR 136
Cdd:COG3173   45 LVLRRPprGLASAHDVRRE-----ARVLRAlAPRLgvpvPRPLALGEDGevigapfYVMEWVEGETLEDALPDlSPAERR 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688548033 137 HIARQMAKYHA-IHAHNgwVPQSGLwlkmskfFSLVPSHFEDP------EMDQRLNNEVPSAACLRDEMIWLQQNLSKLG 209
Cdd:COG3173  120 ALARALGEFLAaLHAVD--PAAAGL-------ADGRPEGLERQlarwraQLRRALARTDDLPALRERLAAWLAANLPEWG 190

                        170       180
                 ....*....|....*....|.
gi 688548033 210 sPVVLCHNDLLCKNIIYNQKE 230
Cdd:COG3173  191 -PPVLVHGDLRPGNLLVDPDD 210
CotS COG0510
Thiamine kinase or a related kinase [Coenzyme transport and metabolism];
194-234 6.74e-04

Thiamine kinase or a related kinase [Coenzyme transport and metabolism];


Pssm-ID: 440276 [Multi-domain]  Cd Length: 156  Bit Score: 39.38  E-value: 6.74e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 688548033 194 LRDEMIWLQQNLSKLGSPVVLCHNDLLCKNIIYNQKEDVSL 234
Cdd:COG0510   31 LLRRLEELERALAARPLPLVLCHGDLHPGNFLVTDDGRLYL 71
APH pfam01636
Phosphotransferase enzyme family; This family consists of bacterial antibiotic resistance ...
 63-227 7.49e-03

Phosphotransferase enzyme family; This family consists of bacterial antibiotic resistance proteins, which confer resistance to various aminoglycosides they include: aminoglycoside 3'-phosphotransferase or kanamycin kinase / neomycin-kanamycin phosphotransferase and streptomycin 3''-kinase or streptomycin 3''-phosphotransferase. The aminoglycoside phosphotransferases inactivate aminoglycoside antibiotics via phosphorylation. This family also includes homoserine kinase. This family is related to fructosamine kinase pfam03881.


Pssm-ID: 426359 [Multi-domain]  Cd Length: 239  Bit Score: 36.71  E-value: 7.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688548033   63 YVGGSMQEVVLvRVYgNKTELFVDRENEVKSFRVLQAHR----CAPRLYCTFNNGLC-----YEFLQGVALEPEHIR--S 131
Cdd:pfam01636  15 LVTTGDGRYVL-RLP-PPGRAAEELRRELALLRHLAAAGvppvPRVLAGCTDAELLGlpfllMEYLPGEVLARPLLPeeR 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688548033  132 PAIFRHIARQMAKYHAIHAhnGWVPQSG---LWLKMSKFFSLVPSHFEDPEMDQRLnnevpsAACLRDEMIWLQQNLsKL 208
Cdd:pfam01636  93 GALLEALGRALARLHAVDP--AALPLAGrlaRLLELLRQLEAALARLLAAELLDRL------EELEERLLAALLALL-PA 163

                         170
                  ....*....|....*....
gi 688548033  209 GSPVVLCHNDLLCKNIIYN 227
Cdd:pfam01636 164 ELPPVLVHGDLHPGNLLVD 182
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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