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Conserved domains on  [gi|755536374|ref|XP_011242005|]
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DNA-binding protein Ikaros isoform X5 [Mus musculus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 13826075)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation; similar to Homo sapiens zinc finger protein 770

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
132-156 3.38e-05

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.82  E-value: 3.38e-05
                          10        20
                  ....*....|....*....|....*
gi 755536374  132 LMVHKRSHTGERPFQCNQCGASFTQ 156
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
159-184 3.42e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.42e-04
                          10        20
                  ....*....|....*....|....*.
gi 755536374  159 NLLRHIKLHSGEKPFKCHLCNYACRR 184
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 super family cl34881
FOG: Zn-finger [General function prediction only];
143-481 1.26e-03

FOG: Zn-finger [General function prediction only];


The actual alignment was detected with superfamily member COG5048:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.22  E-value: 1.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755536374 143 RPFQCNQCGASFTQKGNLLRHIKLHSGEKPFKCHLCNYACR--RRDALTGHLRTHSVGKPHKCGYCGRSYKQRSSLEEHK 220
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSfsRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755536374 221 ERCHNYLESMGLPGMYPVikeETNHNEMAEDLCKIgaerslvldRLASNVAKRDKCLSDMPYDSANYEKEDMMTSHVMDQ 300
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLP---PSSRDPQLPDLLSI---------SNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKD 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755536374 301 AINNAINYLGAE----SLRPLVQTPPGSSEVVPVISSMYQLHKPPSDGPPRSNHSAQDAVDNLLLLSKAKSVSSEREASP 376
Cdd:COG5048  180 PSSNLSLLISSNvstsIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASE 259
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755536374 377 SNSCQDSTDTESNAEEQRSGLIYLTNHINPHARNGLALKeeqrayevlRAASENSQDAFRVVSTSGEQLKVYKCEH--CR 454
Cdd:COG5048  260 SPRSSLPTASSQSSSPNESDSSSEKGFSLPIKSKQCNIS---------FSRSSPLTRHLRSVNHSGESLKPFSCPYslCG 330
                        330       340
                 ....*....|....*....|....*..
gi 755536374 455 VLFLDHVMYTIHMGCHGFRDPFECNMC 481
Cdd:COG5048  331 KLFSRNDALKRHILLHTSISPAKEKLL 357
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
132-156 3.38e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.82  E-value: 3.38e-05
                          10        20
                  ....*....|....*....|....*
gi 755536374  132 LMVHKRSHTGERPFQCNQCGASFTQ 156
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
159-184 3.42e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.42e-04
                          10        20
                  ....*....|....*....|....*.
gi 755536374  159 NLLRHIKLHSGEKPFKCHLCNYACRR 184
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
143-481 1.26e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.22  E-value: 1.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755536374 143 RPFQCNQCGASFTQKGNLLRHIKLHSGEKPFKCHLCNYACR--RRDALTGHLRTHSVGKPHKCGYCGRSYKQRSSLEEHK 220
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSfsRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755536374 221 ERCHNYLESMGLPGMYPVikeETNHNEMAEDLCKIgaerslvldRLASNVAKRDKCLSDMPYDSANYEKEDMMTSHVMDQ 300
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLP---PSSRDPQLPDLLSI---------SNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKD 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755536374 301 AINNAINYLGAE----SLRPLVQTPPGSSEVVPVISSMYQLHKPPSDGPPRSNHSAQDAVDNLLLLSKAKSVSSEREASP 376
Cdd:COG5048  180 PSSNLSLLISSNvstsIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASE 259
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755536374 377 SNSCQDSTDTESNAEEQRSGLIYLTNHINPHARNGLALKeeqrayevlRAASENSQDAFRVVSTSGEQLKVYKCEH--CR 454
Cdd:COG5048  260 SPRSSLPTASSQSSSPNESDSSSEKGFSLPIKSKQCNIS---------FSRSSPLTRHLRSVNHSGESLKPFSCPYslCG 330
                        330       340
                 ....*....|....*....|....*..
gi 755536374 455 VLFLDHVMYTIHMGCHGFRDPFECNMC 481
Cdd:COG5048  331 KLFSRNDALKRHILLHTSISPAKEKLL 357
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
145-169 7.86e-03

C2H2-type zinc-finger domain;


Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 34.06  E-value: 7.86e-03
                          10        20
                  ....*....|....*....|....*
gi 755536374  145 FQCNQCGASFTQKGNLLRHIKLHSG 169
Cdd:pfam13909   1 YKCSQCDYSTAWKSNLKRHLRKHTG 25
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
132-156 3.38e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.82  E-value: 3.38e-05
                          10        20
                  ....*....|....*....|....*
gi 755536374  132 LMVHKRSHTGERPFQCNQCGASFTQ 156
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
159-184 3.42e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.42e-04
                          10        20
                  ....*....|....*....|....*.
gi 755536374  159 NLLRHIKLHSGEKPFKCHLCNYACRR 184
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
145-167 7.05e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.89  E-value: 7.05e-04
                          10        20
                  ....*....|....*....|...
gi 755536374  145 FQCNQCGASFTQKGNLLRHIKLH 167
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
143-481 1.26e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.22  E-value: 1.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755536374 143 RPFQCNQCGASFTQKGNLLRHIKLHSGEKPFKCHLCNYACR--RRDALTGHLRTHSVGKPHKCGYCGRSYKQRSSLEEHK 220
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSfsRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755536374 221 ERCHNYLESMGLPGMYPVikeETNHNEMAEDLCKIgaerslvldRLASNVAKRDKCLSDMPYDSANYEKEDMMTSHVMDQ 300
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLP---PSSRDPQLPDLLSI---------SNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKD 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755536374 301 AINNAINYLGAE----SLRPLVQTPPGSSEVVPVISSMYQLHKPPSDGPPRSNHSAQDAVDNLLLLSKAKSVSSEREASP 376
Cdd:COG5048  180 PSSNLSLLISSNvstsIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASE 259
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755536374 377 SNSCQDSTDTESNAEEQRSGLIYLTNHINPHARNGLALKeeqrayevlRAASENSQDAFRVVSTSGEQLKVYKCEH--CR 454
Cdd:COG5048  260 SPRSSLPTASSQSSSPNESDSSSEKGFSLPIKSKQCNIS---------FSRSSPLTRHLRSVNHSGESLKPFSCPYslCG 330
                        330       340
                 ....*....|....*....|....*..
gi 755536374 455 VLFLDHVMYTIHMGCHGFRDPFECNMC 481
Cdd:COG5048  331 KLFSRNDALKRHILLHTSISPAKEKLL 357
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
144-218 1.64e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.83  E-value: 1.64e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755536374 144 PFQCNQCGASFTQKGNLLRHI--KLHSGE--KPFKC--HLCNYACRRRDALTGHLRTHSVGKPHKCGYCGRSYKQRSSLE 217
Cdd:COG5048  289 PIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLN 368

                 .
gi 755536374 218 E 218
Cdd:COG5048  369 N 369
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
145-169 7.86e-03

C2H2-type zinc-finger domain;


Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 34.06  E-value: 7.86e-03
                          10        20
                  ....*....|....*....|....*
gi 755536374  145 FQCNQCGASFTQKGNLLRHIKLHSG 169
Cdd:pfam13909   1 YKCSQCDYSTAWKSNLKRHLRKHTG 25
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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