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Conserved domains on  [gi|755563639|ref|XP_011245644|]
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rho GTPase-activating protein 19 isoform X2 [Mus musculus]

Protein Classification

Rho GTPase-activating protein( domain architecture ID 10138218)

Rho GTPase-activating protein for Rho/Rac/Cdc42-like small GTPases that act as molecular switches, active in their GTP-bound form but inactive when bound to GDP; similar to mammalian rho GTPase-activating protein 19 (ARHGAP19), which participates in various cytoskeletal-related events, including epithelial morphogenesis

CATH:  1.10.555.10
Gene Ontology:  GO:0007165|GO:0005096
PubMed:  17222083|12480336
SCOP:  4001255

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RhoGAP_ARHGAP19 cd04392
RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 104-311 3.43e-122

RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


:

Pssm-ID: 239857  Cd Length: 208  Bit Score: 354.85  E-value: 3.43e-122
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563639 104 FGSPLTEEGIAQIYQLIEYLHKNLRVEGLFRVPGNSVRQQLLRDALNNGTDIDLDSGEFHSNDVATLLKMFLGELPEPLL 183
Cdd:cd04392    1 FGAPLTEEGIAQIYQLIEYLEKNLRVEGLFRKPGNSARQQELRDLLNSGTDLDLESGGFHAHDCATVLKGFLGELPEPLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563639 184 THKHFHVHLKIADLMQFDDKGNKTNIPDKERQIEALQLLFLILPPANRNLLKLLLDLLYQTAKKQDKNKMSAHNLALMFA 263
Cdd:cd04392   81 THAHYPAHLQIADLCQFDEKGNKTSAPDKERLLEALQLLLLLLPEENRNLLKLILDLLYQTAKHEDKNKMSADNLALLFT 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 755563639 264 PHVLWPKNVTANDLQENIIKLNTGMAFMIKHSQKLFKAPAYIRECARL 311
Cdd:cd04392  161 PHLICPRNLTPEDLHENAQKLNSIVTFMIKHSQKLFKAPAYLREDARA 208
 
Name Accession Description Interval E-value
RhoGAP_ARHGAP19 cd04392
RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 104-311 3.43e-122

RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239857  Cd Length: 208  Bit Score: 354.85  E-value: 3.43e-122
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563639 104 FGSPLTEEGIAQIYQLIEYLHKNLRVEGLFRVPGNSVRQQLLRDALNNGTDIDLDSGEFHSNDVATLLKMFLGELPEPLL 183
Cdd:cd04392    1 FGAPLTEEGIAQIYQLIEYLEKNLRVEGLFRKPGNSARQQELRDLLNSGTDLDLESGGFHAHDCATVLKGFLGELPEPLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563639 184 THKHFHVHLKIADLMQFDDKGNKTNIPDKERQIEALQLLFLILPPANRNLLKLLLDLLYQTAKKQDKNKMSAHNLALMFA 263
Cdd:cd04392   81 THAHYPAHLQIADLCQFDEKGNKTSAPDKERLLEALQLLLLLLPEENRNLLKLILDLLYQTAKHEDKNKMSADNLALLFT 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 755563639 264 PHVLWPKNVTANDLQENIIKLNTGMAFMIKHSQKLFKAPAYIRECARL 311
Cdd:cd04392  161 PHLICPRNLTPEDLHENAQKLNSIVTFMIKHSQKLFKAPAYLREDARA 208
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 116-295 6.80e-38

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 136.24  E-value: 6.80e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563639   116 IYQLIEYLHKN-LRVEGLFRVPGNSVRQQLLRDALNNGTDIDLDSGEFHSNDVATLLKMFLGELPEPLLTHKHFHVHLKI 194
Cdd:smart00324   7 VEKCIEYLEKRgLDTEGIYRVSGSKSRVKELRDAFDSGPDPDLDLSEYDVHDVAGLLKLFLRELPEPLITYELYEEFIEA 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563639   195 AdlmqfddkgnktNIPDKERQIEALQLLFLILPPANRNLLKLLLDLLYQTAKKQDKNKMSAHNLALMFAPHVLWPKNVTA 274
Cdd:smart00324  87 A------------KLEDETERLRALRELLSLLPPANRATLRYLLAHLNRVAEHSEENKMTARNLAIVFGPTLLRPPDGEV 154

                          170       180
                   ....*....|....*....|.
gi 755563639   275 NDLQEnIIKLNTGMAFMIKHS 295
Cdd:smart00324 155 ASLKD-IRHQNTVIEFLIENA 174
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 116-271 3.59e-36

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 130.74  E-value: 3.59e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563639  116 IYQLIEYLHKN-LRVEGLFRVPGNSVRQQLLRDALNNGTDIDLDSGEFHSNDVATLLKMFLGELPEPLLTHKHFHVHLKI 194
Cdd:pfam00620   4 VRKCVEYLEKRgLDTEGIFRVSGSASRIKELREAFDRGPDVDLDLEEEDVHVVASLLKLFLRELPEPLLTFELYEEFIEA 83

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755563639  195 ADlmqfddkgnktnIPDKERQIEALQLLFLILPPANRNLLKLLLDLLYQTAKKQDKNKMSAHNLALMFAPHVLWPKN 271
Cdd:pfam00620  84 AK------------LPDEEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSDVNKMNAHNLAIVFGPTLLRPPD 148
 
Name Accession Description Interval E-value
RhoGAP_ARHGAP19 cd04392
RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 104-311 3.43e-122

RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239857  Cd Length: 208  Bit Score: 354.85  E-value: 3.43e-122
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563639 104 FGSPLTEEGIAQIYQLIEYLHKNLRVEGLFRVPGNSVRQQLLRDALNNGTDIDLDSGEFHSNDVATLLKMFLGELPEPLL 183
Cdd:cd04392    1 FGAPLTEEGIAQIYQLIEYLEKNLRVEGLFRKPGNSARQQELRDLLNSGTDLDLESGGFHAHDCATVLKGFLGELPEPLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563639 184 THKHFHVHLKIADLMQFDDKGNKTNIPDKERQIEALQLLFLILPPANRNLLKLLLDLLYQTAKKQDKNKMSAHNLALMFA 263
Cdd:cd04392   81 THAHYPAHLQIADLCQFDEKGNKTSAPDKERLLEALQLLLLLLPEENRNLLKLILDLLYQTAKHEDKNKMSADNLALLFT 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 755563639 264 PHVLWPKNVTANDLQENIIKLNTGMAFMIKHSQKLFKAPAYIRECARL 311
Cdd:cd04392  161 PHLICPRNLTPEDLHENAQKLNSIVTFMIKHSQKLFKAPAYLREDARA 208
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 116-295 6.80e-38

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 136.24  E-value: 6.80e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563639   116 IYQLIEYLHKN-LRVEGLFRVPGNSVRQQLLRDALNNGTDIDLDSGEFHSNDVATLLKMFLGELPEPLLTHKHFHVHLKI 194
Cdd:smart00324   7 VEKCIEYLEKRgLDTEGIYRVSGSKSRVKELRDAFDSGPDPDLDLSEYDVHDVAGLLKLFLRELPEPLITYELYEEFIEA 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563639   195 AdlmqfddkgnktNIPDKERQIEALQLLFLILPPANRNLLKLLLDLLYQTAKKQDKNKMSAHNLALMFAPHVLWPKNVTA 274
Cdd:smart00324  87 A------------KLEDETERLRALRELLSLLPPANRATLRYLLAHLNRVAEHSEENKMTARNLAIVFGPTLLRPPDGEV 154

                          170       180
                   ....*....|....*....|.
gi 755563639   275 NDLQEnIIKLNTGMAFMIKHS 295
Cdd:smart00324 155 ASLKD-IRHQNTVIEFLIENA 174
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 116-271 3.59e-36

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 130.74  E-value: 3.59e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563639  116 IYQLIEYLHKN-LRVEGLFRVPGNSVRQQLLRDALNNGTDIDLDSGEFHSNDVATLLKMFLGELPEPLLTHKHFHVHLKI 194
Cdd:pfam00620   4 VRKCVEYLEKRgLDTEGIFRVSGSASRIKELREAFDRGPDVDLDLEEEDVHVVASLLKLFLRELPEPLLTFELYEEFIEA 83

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755563639  195 ADlmqfddkgnktnIPDKERQIEALQLLFLILPPANRNLLKLLLDLLYQTAKKQDKNKMSAHNLALMFAPHVLWPKN 271
Cdd:pfam00620  84 AK------------LPDEEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSDVNKMNAHNLAIVFGPTLLRPPD 148
RhoGAP cd00159
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like ...
 116-294 5.74e-36

RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.


Pssm-ID: 238090 [Multi-domain]  Cd Length: 169  Bit Score: 130.88  E-value: 5.74e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563639 116 IYQLIEYLHKN-LRVEGLFRVPGNSVRQQLLRDALNNGTDIDLDSgEFHSNDVATLLKMFLGELPEPLLTHKHFHVHLKI 194
Cdd:cd00159    4 IEKCIEYLEKNgLNTEGIFRVSGSASKIEELKKKFDRGEDIDDLE-DYDVHDVASLLKLYLRELPEPLIPFELYDEFIEL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563639 195 AdlmqfddkgnktNIPDKERQIEALQLLFLILPPANRNLLKLLLDLLYQTAKKQDKNKMSAHNLALMFAPHVLWPKNVTA 274
Cdd:cd00159   83 A------------KIEDEEERIEALKELLKSLPPENRDLLKYLLKLLHKISQNSEVNKMTASNLAIVFAPTLLRPPDSDD 150

                        170       180
                 ....*....|....*....|
gi 755563639 275 NDLqENIIKLNTGMAFMIKH 294
Cdd:cd00159  151 ELL-EDIKKLNEIVEFLIEN 169
RhoGAP_ARHGAP18 cd04391
RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 103-305 4.98e-27

RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239856  Cd Length: 216  Bit Score: 107.82  E-value: 4.98e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563639 103 VFGSPLT-----------EEGIAQIYQ-LIEYLHKN-LRVEGLFRVPGNSVRQQLLRDALN---NGTDIDLDSgeFHSND 166
Cdd:cd04391    1 LFGVPLStllerdqkkvpGSKVPLIFQkLINKLEERgLETEGILRIPGSAQRVKFLCQELEakfYEGTFLWDQ--VKQHD 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563639 167 VATLLKMFLGELPEPLLTHKHFHVHLKIadlmqfddkgnkTNIPDKERQIEALQLLFLILPPANRNLLKLLLDLLYQTAK 246
Cdd:cd04391   79 AASLLKLFIRELPQPLLTVEYLPAFYSV------------QGLPSKKDQLQALNLLVLLLPEANRDTLKALLEFLQKVVD 146

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755563639 247 KQDKNKMSAHNLALMFAPHVLWPK---NVTANDLQENIIKLNTG---MAFMIKHSQKLFKAPAYI 305
Cdd:cd04391  147 HEEKNKMNLWNVAMIMAPNLFPPRgkhSKDNESLQEEVNMAAGCaniMRLLIRYQDLLWTVPSFL 211
RhoGAP_nadrin cd04386
RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 103-299 6.06e-22

RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in tight junction maintenance in mammalian epithelium. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239851  Cd Length: 203  Bit Score: 93.29  E-value: 6.06e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563639 103 VFGSPL------TEEGIAQIYQL-IEYLHKN-LRVEGLFRVPGNSVRQQLLRDALNNGTdIDLDSGEFHSND--VATLLK 172
Cdd:cd04386    4 VFGTPLeehlkrTGREIALPIEAcVMCLLETgMNEEGLFRVGGGASKLKRLKAALDAGT-FSLPLDEFYSDPhaVASALK 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563639 173 MFLGELPEPLLTHKHFHVHLKIAdlmqfddkgnktNIPDKERQIEALQLLFLILPPANRNLLKLLLDLLYQTAKKQDKNK 252
Cdd:cd04386   83 SYLRELPDPLLTYNLYEDWVQAA------------NKPDEDERLQAIWRILNKLPRENRDNLRYLIKFLSKLAQKSDENK 150

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 755563639 253 MSAHNLALMFAPHVLWPKNVTANDLQE--NIIKLNTGMAFMIKHSQKLF 299
Cdd:cd04386  151 MSPSNIAIVLAPNLLWAKNEGSLAEMAagTSVHVVAIVELIISHADWFF 199
RhoGAP-p50rhoGAP cd04404
RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 104-299 1.19e-21

RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). It is ubiquitously expressed and preferentially active on Cdc42. This subgroup also contains closely related ARHGAP8. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239869 [Multi-domain]  Cd Length: 195  Bit Score: 92.40  E-value: 1.19e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563639 104 FGSPLT--------EEGIAQIY-QLIEYLHKN-LRVEGLFRVPGNSVRQQLLRDALNNGTDIDLDSgefhSNDV---ATL 170
Cdd:cd04404    6 FGVSLQflkeknpeQEPIPPVVrETVEYLQAHaLTTEGIFRRSANTQVVKEVQQKYNMGEPVDFDQ----YEDVhlpAVI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563639 171 LKMFLGELPEPLLThkhFHVHLKIADLmqfddkgnkTNIpDKERQIEALQLLFLILPPANRNLLKLLLDLLYQTAKKQDK 250
Cdd:cd04404   82 LKTFLRELPEPLLT---FDLYDDIVGF---------LNV-DKEERVERVKQLLQTLPEENYQVLKYLIKFLVQVSAHSDQ 148

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 755563639 251 NKMSAHNLALMFAPHVLWPKNVTANdlQENIIKLNTGMAFMIKHSQKLF 299
Cdd:cd04404  149 NKMTNSNLAVVFGPNLLWAKDASMS--LSAINPINTFTKFLLDHQDEIF 195
RhoGAP_ARHGAP6 cd04376
RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 115-305 3.54e-21

RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS); MLS is a severe X-linked developmental disorder. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239841  Cd Length: 206  Bit Score: 91.35  E-value: 3.54e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563639 115 QIYQLIE----YLHKN-LRVEGLFRVPGNSVRQQLLRDALNNGTDIDLDSgEFHSNDVATLLKMFLGELPEPLLTHKHFH 189
Cdd:cd04376    8 QVPRLVEsccqHLEKHgLQTVGIFRVGSSKKRVRQLREEFDRGIDVVLDE-NHSVHDVAALLKEFFRDMPDPLLPRELYT 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563639 190 VHLKIADLmqfddkgnktnipDKERQIEALQLLFLILPPANRNLLKLLLDLLYQTAKKQDK-----------NKMSAHNL 258
Cdd:cd04376   87 AFIGTALL-------------EPDEQLEALQLLIYLLPPCNCDTLHRLLKFLHTVAEHAADsidedgqevsgNKMTSLNL 153

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 755563639 259 ALMFAPHVL-------WPKNVTANDLQENIIKLNTGMAfMIKHSQKLFKAPAYI 305
Cdd:cd04376  154 ATIFGPNLLhkqksgeREFVQASLRIEESTAIINVVQT-MIDNYEELFMVSPEL 206
RhoGAP-ARHGAP11A cd04394
RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 103-267 1.06e-20

RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP11A-like proteins. The mouse homolog of human ArhGAP11A has been detected as a gene exclusively expressed in immature ganglion cells, potentially playing a role in retinal development. The exact function of ArhGAP11A is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239859 [Multi-domain]  Cd Length: 202  Bit Score: 89.84  E-value: 1.06e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563639 103 VFGSPL--------TEEG-IAQI-YQLIEYLHKNLRVEGLFRVPGNSVRQQLLRDALNNGTDIDldsGEFHSNDVATLLK 172
Cdd:cd04394    1 VFGVPLhslphstvPEYGnVPKFlVDACTFLLDHLSTEGLFRKSGSVVRQKELKAKLEGGEACL---SSALPCDVAGLLK 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563639 173 MFLGELPEPLLTHKHFHVHLKIADLmqfddkgnktniPDKERQIEALQLLFLILPPANRNLLKLLLDLLYQTAKKQDKNK 252
Cdd:cd04394   78 QFFRELPEPLLPYDLHEALLKAQEL------------PTDEERKSATLLLTCLLPDEHVNTLRYFFSFLYDVAQRCSENK 145

                        170
                 ....*....|....*
gi 755563639 253 MSAHNLALMFAPHVL 267
Cdd:cd04394  146 MDSSNLAVIFAPNLF 160
RhoGAP_myosin_IX cd04377
RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 118-293 1.06e-18

RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239842  Cd Length: 186  Bit Score: 83.64  E-value: 1.06e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563639 118 QLIEYLHKN-LRVEGLFRVPGNSVRQQLLRDALNNGTD-IDLDSGEFHSndVATLLKMFLGELPEPLLTHKHFHVHLKIA 195
Cdd:cd04377   21 KLLEHIEMHgLYTEGIYRKSGSANKIKELRQGLDTDPDsVNLEDYPIHV--ITSVLKQWLRELPEPLMTFELYENFLRAM 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563639 196 DLmqfddkgnktniPDKERQIEALQLLFLILPPANRNLLKLLLDLLYQTAKKQDKNKMSAHNLALMFAPHVL-WPKNVTA 274
Cdd:cd04377   99 EL------------EEKQERVRALYSVLEQLPRANLNTLERLIFHLVRVALQEEVNRMSANALAIVFAPCILrCPDTADP 166

                        170
                 ....*....|....*....
gi 755563639 275 NDLQENIIKLNTGMAFMIK 293
Cdd:cd04377  167 LQSLQDVSKTTTCVETLIK 185
RhoGAP_DLC1 cd04375
RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 103-304 2.92e-18

RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START (StAR-related lipid transfer action) domain. DLC1 has tumor suppressor activity in cell culture. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239840  Cd Length: 220  Bit Score: 83.24  E-value: 2.92e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563639 103 VFGSPL------TEEGIAQ-IYQLIEYLHKN-LRVEGLFRVPGNSVRQQLLRDaLNNGTDIDLDSGEFHSNDVATLLKMF 174
Cdd:cd04375    4 VFGVPLlvnlqrTGQPLPRsIQQAMRWLRNNaLDQVGLFRKSGVKSRIQKLRS-MIESSTDNVNYDGQQAYDVADMLKQY 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563639 175 LGELPEPLLTHKHFHVHLKIadlMQFddkgnktnIPDKERqIEALQLLFLILPPANRNLLKLLLDLLYQTAKKQDKNKMS 254
Cdd:cd04375   83 FRDLPEPLLTNKLSETFIAI---FQY--------VPKEQR-LEAVQCAILLLPDENREVLQTLLYFLSDVAANSQENQMT 150

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755563639 255 AHNLALMFAP---HVLWPKNVTANDLQENIIKLNTGM----------------AFMIKHSQKLFKAPAY 304
Cdd:cd04375  151 ATNLAVCLAPslfHLNTSRRENSSPARRMQRKKSLGKpdqkelsenkaahqclAYMIEECNTLFMVPKE 219
RhoGAP_ARHGAP27_15_12_9 cd04403
RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 125-275 5.19e-18

RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are studied show GAP activity towards Rac1, some additionally show activity towards Cdc42. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239868 [Multi-domain]  Cd Length: 187  Bit Score: 81.67  E-value: 5.19e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563639 125 KNLRVEGLFRVPGNSVRQQLLRDALNNGTDIDLDSGEFHSNDVAT-LLKMFLGELPEPLLTHKHFhvhlkiadlmqfDDK 203
Cdd:cd04403   30 RGLDVDGIYRVSGNLAVIQKLRFAVDHDEKLDLDDSKWEDIHVITgALKLFFRELPEPLFPYSLF------------NDF 97

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755563639 204 GNKTNIPDKERQIEALQLLFLILPPANRNLLKLLLDLLYQTAKKQDKNKMSAHNLALMFAPHVLWPKNVTAN 275
Cdd:cd04403   98 VAAIKLSDYEQRVSAVKDLIKSLPKPNHDTLKMLFRHLCRVIEHGEKNRMTTQNLAIVFGPTLLRPEQETGN 169
RhoGAP_GMIP_PARG1 cd04378
RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 120-274 6.40e-18

RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein) and PARG1 (PTPL1-associated RhoGAP1). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239843  Cd Length: 203  Bit Score: 82.09  E-value: 6.40e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563639 120 IEylHKNLRVEGLFRVPGNSVRQQLLRDALNNGTDIdLDSGEFHSNDVATLLKMFLGELPEPLLTHKHFHVHLKIA-DLM 198
Cdd:cd04378   27 IE--NRALGVQGIYRVSGSKARVEKLCQAFENGKDL-VELSELSPHDISSVLKLFLRQLPEPLILFRLYNDFIALAkEIQ 103

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755563639 199 QFDDKGNKTNIP-DKERQIEALQLLFLILPPANRNLLKLLLDLLYQTAKKQDKNKMSAHNLALMFAPHVLWPKNVTA 274
Cdd:cd04378  104 RDTEEDKAPNTPiEVNRIIRKLKDLLRQLPASNYNTLQHLIAHLYRVAEQFEENKMSPNNLGIVFGPTLIRPRPGDA 180
RhoGAP_ARHGAP20 cd04402
RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 130-299 5.14e-17

RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by Rap1 and induces inactivation of Rho, which in turn leads to neurite outgrowth. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239867  Cd Length: 192  Bit Score: 78.88  E-value: 5.14e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563639 130 EGLFRVPGNSVRQQLLRDALNNGTDIDLDSGEFHSndVATLLKMFLGELPEPLLTHKHFHVHLKIADLmqfddkgnktni 209
Cdd:cd04402   34 EGIFRRSANAKACKELKEKLNSGVEVDLKAEPVLL--LASVLKDFLRNIPGSLLSSDLYEEWMSALDQ------------ 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563639 210 PDKERQIEALQLLFLILPPANRNLLKLLLDLLYQTAKKQDKNKMSAHNLALMFAPHVLWPkNVTANDLQENIIKLNTGMA 289
Cdd:cd04402  100 ENEEEKIAELQRLLDKLPRPNVLLLKHLICVLHNISQNSETNKMDAFNLAVCIAPSLLWP-PASSELQNEDLKKVTSLVQ 178

                        170
                 ....*....|
gi 755563639 290 FMIKHSQKLF 299
Cdd:cd04402  179 FLIENCQEIF 188
RhoGAP_fLRG1 cd04397
RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 125-305 7.42e-17

RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal LRG1-like proteins. Yeast Lrg1p is required for efficient cell fusion, and mother-daughter cell separation, possibly through acting as a RhoGAP specifically regulating 1,3-beta-glucan synthesis. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239862  Cd Length: 213  Bit Score: 79.33  E-value: 7.42e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563639 125 KNLRVEGLFRVPGNSVRQQLLRDALNNGTDIDLDSGEFHSNDVATLLKMFLGELPEPLLTHKHFHVHLKIADlmqfddkg 204
Cdd:cd04397   41 MDMSVEGVFRKNGNIRRLKELTEEIDKNPTEVPDLSKENPVQLAALLKKFLRELPDPLLTFKLYRLWISSQK-------- 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563639 205 nktnIPDKERQIEALQLLFLILPPANRNLLKLLLDLLYQTAK-----KQDKNKMSAHNLALMFAPHVLWPKNvTANDLQE 279
Cdd:cd04397  113 ----IEDEEERKRVLHLVYCLLPKYHRDTMEVLFSFLKWVSSfshidEETGSKMDIHNLATVITPNILYSKT-DNPNTGD 187

                        170       180
                 ....*....|....*....|....*.
gi 755563639 280 NIIKLNTGMAFMIKHSQKLFKAPAYI 305
Cdd:cd04397  188 EYFLAIEAVNYLIENNEEFCEVPDEL 213
RhoGAP_ARAP cd04385
RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 127-270 1.11e-16

RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity is PIP3-dependent, ARAPs are considered integration points for phosphoinositide, Arf and Rho signaling. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239850  Cd Length: 184  Bit Score: 77.73  E-value: 1.11e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563639 127 LRVEGLFRVPG-NSVRQQLL----RDALNngtdIDLDSGEFHSNDVATLLKMFLGELPEPLLTHKHFHVHLKIADlmqfd 201
Cdd:cd04385   31 LMSEGIYRKNGkNSSVKKLLeafrKDARS----VQLREGEYTVHDVADVLKRFLRDLPDPLLTSELHAEWIEAAE----- 101

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755563639 202 dkgnktnIPDKERQIEALQLLFLILPPANRNLLKLLLDLLYQTAKKQDKNKMSAHNLALMFAPHVLWPK 270
Cdd:cd04385  102 -------LENKDERIARYKELIRRLPPINRATLKVLIGHLYRVQKHSDENQMSVHNLALVFGPTLFQTD 163
RhoGAP_myosin_IXB cd04407
RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 101-293 2.27e-16

RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXB. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239872 [Multi-domain]  Cd Length: 186  Bit Score: 76.95  E-value: 2.27e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563639 101 GVVFGSPLTEEGIAQIY--QLIEYLHKN-LRVEGLFRVPGNSVRQQLLRDALNNG-TDIDLDSGEFHSndVATLLKMFLG 176
Cdd:cd04407    2 GVRVGSLTSNKTSVPIVleKLLEHVEMHgLYTEGIYRKSGSANRMKELHQLLQADpENVKLENYPIHA--ITGLLKQWLR 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563639 177 ELPEPLLTHKHFHVHLKIADLmqfddkgnktniPDKERQIEALQLLFLILPPANRNLLKLLLDLLYQTAKKQDKNKMSAH 256
Cdd:cd04407   80 ELPEPLMTFAQYNDFLRAVEL------------PEKQEQLQAIYRVLEQLPTANHNTLERLIFHLVKVALEEDVNRMSPN 147

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 755563639 257 NLALMFAPHVL-WPKNVTANDLQENIIKLNTGMAFMIK 293
Cdd:cd04407  148 ALAIVFAPCLLrCPDSSDPLTSMKDVAKTTTCVEMLIK 185
RhoGAP_fSAC7_BAG7 cd04396
RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 122-298 3.26e-16

RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal SAC7 and BAG7-like proteins. Both proteins are GTPase activating proteins of Rho1, but differ functionally in vivo: SAC7, but not BAG7, is involved in the control of Rho1-mediated activation of the PKC-MPK1 pathway. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239861  Cd Length: 225  Bit Score: 77.45  E-value: 3.26e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563639 122 YLHKN-LRVEGLFRVPGNSVRQQLLRDALNNGTDI--DLDSGEFHSNDVATLLKMFLGELPEPLLTHKHF----HVHLKI 194
Cdd:cd04396   42 YLKENaTEVEGIFRVAGSSKRIRELQLIFSTPPDYgkSFDWDGYTVHDAASVLRRYLNNLPEPLVPLDLYeefrNPLRKR 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563639 195 ADLMQFDDKGNKTNIP-DKERQIEALQLLFLILPPANRNLLKLLLDLLYQTAKKQDKNKMSAHNLALMFAPHVLwpkNVT 273
Cdd:cd04396  122 PRILQYMKGRINEPLNtDIDQAIKEYRDLITRLPNLNRQLLLYLLDLLAVFARNSDKNLMTASNLAAIFQPGIL---SHP 198

                        170       180
                 ....*....|....*....|....*.
gi 755563639 274 ANDLQENIIKLN-TGMAFMIKHSQKL 298
Cdd:cd04396  199 DHEMDPKEYKLSrLVVEFLIEHQDKF 224
RhoGAP_ARHGAP21 cd04395
RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 125-271 5.85e-16

RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction complex. It has been shown to function as a GAP of Cdc42 and RhoA, and to interact with alpha-catenin and Arf6. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239860  Cd Length: 196  Bit Score: 76.28  E-value: 5.85e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563639 125 KNLRVEGLFRVPGNSVRQQLLRDALNNG-TDIDLDSGEFHS-NDVATLLKMFLGELPEPLLTHKHFHVHLKiadlmqfdd 202
Cdd:cd04395   32 RGLETVGIYRVPGNNAAISALQEELNRGgFDIDLQDPRWRDvNVVSSLLKSFFRKLPEPLFTNELYPDFIE--------- 102

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755563639 203 kGNKtnIPDKERQIEALQLLFLILPPANRNLLKLLLDLLYQTAKKQDKNKMSAHNLALMFAPHVLWPKN 271
Cdd:cd04395  103 -ANR--IEDPVERLKELRRLIHSLPDHHYETLKHLIRHLKTVADNSEVNKMEPRNLAIVFGPTLVRTSD 168
RhoGAP_FAM13A1a cd04393
RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 103-266 1.04e-15

RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by up several orders of magnitude.


Pssm-ID: 239858 [Multi-domain]  Cd Length: 189  Bit Score: 75.19  E-value: 1.04e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563639 103 VFGSPL--------TEEGI-AQIYQLIEYLHKN-LRVEGLFRVPGNSVRQQLLRDALNNGTDIDLdSGEFHSNDVATLLK 172
Cdd:cd04393    2 VFGVPLqelqqagqPENGVpAVVRHIVEYLEQHgLEQEGLFRVNGNAETVEWLRQRLDSGEEVDL-SKEADVCSAASLLR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563639 173 MFLGELPEPLLT---HKHfhvhlkiadLMQFDDKGNKtnipdKERQIEALQLLFLILPPANRNLLKLLLDLLYQTAKKQD 249
Cdd:cd04393   81 LFLQELPEGLIPaslQIR---------LMQLYQDYNG-----EDEFGRKLRDLLQQLPPVNYSLLKFLCHFLSNVASQHH 146

                        170
                 ....*....|....*..
gi 755563639 250 KNKMSAHNLALMFAPHV 266
Cdd:cd04393  147 ENRMTAENLAAVFGPDV 163
RhoGAP_ARHGAP22_24_25 cd04390
RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 125-299 1.17e-15

RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for Rac1 and Cdc42. Short isoforms (without the PH domain) of ARHGAP24, called RC-GAP72 and p73RhoGAP, and of ARHGAP22, called p68RacGAP, has been shown to be involved in angiogenesis and endothelial cell capillary formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239855 [Multi-domain]  Cd Length: 199  Bit Score: 75.17  E-value: 1.17e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563639 125 KNLRVEGLFRVPG--NSVRQqlLRDALNNGTDIDLDSG-EFHSndVATLLKMFLGELPEPLLTHKHFHVHLKIADLMQfd 201
Cdd:cd04390   36 HGLKEEGLFRLPGqaNLVKQ--LQDAFDAGERPSFDSDtDVHT--VASLLKLYLRELPEPVIPWAQYEDFLSCAQLLS-- 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563639 202 dkgnktniPDKERQIEALQLLFLILPPANRNLLKLLLDLLYQTAKKQDKNKMSAHNLALMFAPHVLWPKNVTANDLQENI 281
Cdd:cd04390  110 --------KDEEKGLGELMKQVSILPKVNYNLLSYICRFLDEVQSNSSVNKMSVQNLATVFGPNILRPKVEDPATIMEGT 181

                        170
                 ....*....|....*...
gi 755563639 282 IKLNTGMAFMIKHSQKLF 299
Cdd:cd04390  182 PQIQQLMTVMISKHEPLF 199
RhoGAP_PARG1 cd04409
RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 127-274 1.41e-15

RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of PARG1 (PTPL1-associated RhoGAP1). PARG1 was originally cloned as an interaction partner of PTPL1, an intracellular protein-tyrosine phosphatase. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239874  Cd Length: 211  Bit Score: 75.23  E-value: 1.41e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563639 127 LRVEGLFRVPGNSVRQQLLRDALNNGTDIdLDSGEFHSNDVATLLKMFLGELPEPLLTHKHFHVHLKIADLMQFDDKGNK 206
Cdd:cd04409   32 LCLKGIYRVNGAKSRVEKLCQAFENGKDL-VELSELSPHDISNVLKLYLRQLPEPLILFRLYNEFIGLAKESQHVNETQE 110

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755563639 207 T-NIPDKERQ---IEALQLLFLI------LPPANRNLLKLLLDLLYQTAKKQDKNKMSAHNLALMFAPHVLWPKNVTA 274
Cdd:cd04409  111 AkKNSDKKWPnmcTELNRILLKSkdllrqLPAPNYNTLQFLIVHLHRVSEQAEENKMSASNLGIIFGPTLIRPRPTDA 188
RhoGAP_fBEM3 cd04400
RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of ...
 103-264 1.73e-15

RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of fungal BEM3-like proteins. Bem3 is a GAP protein of Cdc42, and is specifically involved in the control of the initial assembly of the septin ring in yeast bud formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239865 [Multi-domain]  Cd Length: 190  Bit Score: 74.70  E-value: 1.73e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563639 103 VFGSPLTE-----------EGIAQI-YQLIEYLHKN--LRVEGLFRVPGNSVRQQLLRDALNNGTDIDL--DSGEFHSND 166
Cdd:cd04400    1 IFGSPLEEavelsshkyngRDLPSVvYRCIEYLDKNraIYEEGIFRLSGSASVIKQLKERFNTEYDVDLfsSSLYPDVHT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563639 167 VATLLKMFLGELPEPLLT---HKHFHvhlKIADLMqfddkgnktniPDKERQIEALQLLFLILPPANRNLLKLLLDLLYQ 243
Cdd:cd04400   81 VAGLLKLYLRELPTLILGgelHNDFK---RLVEEN-----------HDRSQRALELKDLVSQLPQANYDLLYVLFSFLRK 146

                        170       180
                 ....*....|....*....|.
gi 755563639 244 TAKKQDKNKMSAHNLALMFAP 264
Cdd:cd04400  147 IIEHSDVNKMNLRNVCIVFSP 167
RhoGAP_p190 cd04373
RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 104-269 1.77e-15

RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and consists of an N-terminal GTPase domain and a C-terminal GAP domain. The central portion of p190 contains important regulatory phosphorylation sites. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239838  Cd Length: 185  Bit Score: 74.41  E-value: 1.77e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563639 104 FGSPLTEEGIAQ------IYQLIEYLHKN-LRVEGLFRVPGNSVRQQLLRDALNNGTDIDLDSGEFHSNDVATLLKMFLG 176
Cdd:cd04373    1 FGVPLANVVTSEkpipifLEKCVEFIEATgLETEGIYRVSGNKTHLDSLQKQFDQDHNLDLVSKDFTVNAVAGALKSFFS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563639 177 ELPEPLLThKHFHVHLKIAdlmqfddkgnkTNIPDKERQIEALQLLFLILPPANRNLLKLLLDLLYQTAKKQDKNKMSAH 256
Cdd:cd04373   81 ELPDPLIP-YSMHLELVEA-----------AKINDREQRLHALKELLKKFPPENFDVFKYVITHLNKVSQNSKVNLMTSE 148

                        170
                 ....*....|...
gi 755563639 257 NLALMFAPHVLWP 269
Cdd:cd04373  149 NLSICFWPTLMRP 161
RhoGAP_fRGD1 cd04398
RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 104-264 2.97e-15

RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal RGD1-like proteins. Yeast Rgd1 is a GAP protein for Rho3 and Rho4 and plays a role in low-pH response. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239863  Cd Length: 192  Bit Score: 73.98  E-value: 2.97e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563639 104 FGSPLTE----EGI---AQIYQLIEYLHK-NLRVEGLFRVPGNSVRQQLLRDAL-NNGTDIDLDSGEFHSND---VATLL 171
Cdd:cd04398    1 FGVPLEDlilrEGDnvpNIVYQCIQAIENfGLNLEGIYRLSGNVSRVNKLKELFdKDPLNVLLISPEDYESDihsVASLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563639 172 KMFLGELPEPLLTHKHFHvhlkiadlmQFDDKGNktnIPDKERQIEALQLLFLILPPANRNLLKLLLDLLYQTAKKQDKN 251
Cdd:cd04398   81 KLFFRELPEPLLTKALSR---------EFIEAAK---IEDESRRRDALHGLINDLPDANYATLRALMFHLARIKEHESVN 148

                        170
                 ....*....|...
gi 755563639 252 KMSAHNLALMFAP 264
Cdd:cd04398  149 RMSVNNLAIIWGP 161
RhoGAP_GMIP cd04408
RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP ...
 121-269 5.34e-15

RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239873  Cd Length: 200  Bit Score: 73.31  E-value: 5.34e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563639 121 EYLHKNLRVEGLFRVPGNSVRQQLLRDALNNGTDIdLDSGEFHSNDVATLLKMFLGELPEPLLTHKHFHVHLKIADLMQF 200
Cdd:cd04408   26 EIENRALGVQGIYRISGSKARVEKLCQAFENGRDL-VDLSGHSPHDITSVLKHFLKELPEPVLPFQLYDDFIALAKELQR 104

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755563639 201 D--DKGNKTNIPdkERQIEALQLLFLILPPANRNLLKLLLDLLYQTAKKQDKNKMSAHNLALMFAPHVLWP 269
Cdd:cd04408  105 DseKAAESPSIV--ENIIRSLKELLGRLPVSNYNTLRHLMAHLYRVAERFEDNKMSPNNLGIVFGPTLLRP 173
RhoGAP_Bcr cd04387
RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr ...
 125-269 2.69e-14

RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr kinase domain, an N-terminal oligomerization domain, and a C-terminal PDZ binding domain, in addition to PH and C2 domains. Bcr is a negative regulator of: i) RacGTPase, via the Rho GAP domain, ii) the Ras-Raf-MEK-ERK pathway, via phosphorylation of the Ras binding protein AF-6, and iii) the Wnt signaling pathway through binding beta-catenin. Bcr can form a complex with beta-catenin and Tcf1. The Wnt signaling pathway is involved in cell proliferation, differentiation, and cell renewal. Bcr was discovered as a fusion partner of Abl. The Bcr-Abl fusion is characteristic for a large majority of chronic myelogenous leukemias (CML). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239852 [Multi-domain]  Cd Length: 196  Bit Score: 71.50  E-value: 2.69e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563639 125 KNLRVEGLFRVPGNSVRQQLLRDALN-NGTDIDLDSGEFHSNDVATLLKMFLGELPEPLLTHKHFhvhLKIADLMQFDDK 203
Cdd:cd04387   30 RGMEEVGIYRISGVATDIQALKAAFDtNNKDVSVMLSEMDVNAIAGTLKLYFRELPEPLFTDELY---PNFAEGIALSDP 106

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755563639 204 GNKTNipdkerqieALQLLFLILPPANRNLLKLLLDLLYQTAKKQDKNKMSAHNLALMFAPHVLWP 269
Cdd:cd04387  107 VAKES---------CMLNLLLSLPDPNLVTFLFLLHHLKRVAEREEVNKMSLHNLATVFGPTLLRP 163
RhoGap_RalBP1 cd04381
RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 104-266 8.56e-13

RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in RalBP1 proteins, also known as RLIP, RLIP76 or cytocentrin. RalBP1 plays an important role in endocytosis during interphase. During mitosis, RalBP1 transiently associates with the centromere and has been shown to play an essential role in the proper assembly of the mitotic apparatus. RalBP1 is an effector of the Ral GTPase which itself is an effector of Ras. RalBP1 contains a RhoGAP domain, which shows weak activity towards Rac1 and Cdc42, but not towards Ral, and a Ral effector domain binding motif. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239846 [Multi-domain]  Cd Length: 182  Bit Score: 66.69  E-value: 8.56e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563639 104 FGSPLTE--------EGI---AQIYQLIEYLHK-NLRVEGLFRVPGNSVRQQLLRDALNNGTDIDLDsgEFHSNDVATLL 171
Cdd:cd04381    1 FGASLSLaversrchDGIdlpLVFRECIDYVEKhGMKCEGIYKVSGIKSKVDELKAAYNRRESPNLE--EYEPPTVASLL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563639 172 KMFLGELPEPLLThkhfhvhlkiADLM-QFDDKGNKTNIPDKERQieaLQLLFLILPPANRNLLKLLLDLLYQTAKKQDK 250
Cdd:cd04381   79 KQYLRELPEPLLT----------KELMpRFEEACGRPTEAEREQE---LQRLLKELPECNRLLLAWLIVHMDHVIAQELE 145

                        170
                 ....*....|....*.
gi 755563639 251 NKMSAHNLALMFAPHV 266
Cdd:cd04381  146 TKMNIQNISIVLSPTV 161
RhoGAP_Graf cd04374
RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase ...
 94-273 2.88e-11

RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal changes mediated by Rho proteins. Graf exhibits GAP activity toward RhoA and Cdc42, but only weakly activates Rac1. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239839  Cd Length: 203  Bit Score: 62.80  E-value: 2.88e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563639  94 SLKRKEKGVVFGSPLTEEGIAQIYQLIEYLH-KNLRVEGLFRVPG-NSVRQQLLRDALNNGT----DIDLDSGEFHSNDV 167
Cdd:cd04374   10 SPGRLQSEVEGEAQLDDIGFKFVRKCIEAVEtRGINEQGLYRVVGvNSKVQKLLSLGLDPKTstpgDVDLDNSEWEIKTI 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563639 168 ATLLKMFLGELPEPLLT---HKHFHVHLKIADLmqfddkgnktnipdkERQIEALQLLFLILPPANRNLLKLLLDLLYQT 244
Cdd:cd04374   90 TSALKTYLRNLPEPLMTyelHNDFINAAKSENL---------------ESRVNAIHSLVHKLPEKNREMLELLIKHLTNV 154

                        170       180
                 ....*....|....*....|....*....
gi 755563639 245 AKKQDKNKMSAHNLALMFAPHVLWPKNVT 273
Cdd:cd04374  155 SDHSKKNLMTVSNLGVVFGPTLLRPQEET 183
RhoGAP_chimaerin cd04372
RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 125-299 3.79e-11

RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms that each contain a C-terminal GAP domain, and a central C1 domain which binds phorbol esters, inducing a conformational change that activates the protein; one splice form is lacking the N-terminal Src homology-2 (SH2) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239837 [Multi-domain]  Cd Length: 194  Bit Score: 62.15  E-value: 3.79e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563639 125 KNLRVEGLFRVPGNSVRQQLLRDALN-NGTDIDLDSGEFHS-NDVATLLKMFLGELPEPLLThkhFHVHLKIADLMQfdd 202
Cdd:cd04372   30 RGLQSEGLYRVSGFAEEIEDVKMAFDrDGEKADISATVYPDiNVITGALKLYFRDLPIPVIT---YDTYPKFIDAAK--- 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563639 203 kgnktnIPDKERQIEALQLLFLILPPANRNLLKLLLDLLYQTAKKQDKNKMSAHNLALMFAPHVLWPKNVTA----NDLQ 278
Cdd:cd04372  104 ------ISNPDERLEAVHEALMLLPPAHYETLRYLMEHLKRVTLHEKDNKMNAENLGIVFGPTLMRPPEDSAlttlNDMR 177

                        170       180
                 ....*....|....*....|.
gi 755563639 279 ENIIKLNTgmafMIKHSQKLF 299
Cdd:cd04372  178 YQILIVQL----LITNEDVLF 194
RhoGAP_CdGAP cd04384
RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 103-270 1.07e-09

RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to focal adhesions via the interaction with the scaffold protein actopaxin (alpha-parvin). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239849 [Multi-domain]  Cd Length: 195  Bit Score: 57.90  E-value: 1.07e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563639 103 VFGSPLTE------EGIAQIYQ-LIEYLHKNLRVEGLFRVPGNSVRQQLLRDALNNGTDIDLDSGEF----HSndVATLL 171
Cdd:cd04384    2 VFGCDLTEhllnsgQDVPQVLKsCTEFIEKHGIVDGIYRLSGIASNIQRLRHEFDSEQIPDLTKDVYiqdiHS--VSSLC 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563639 172 KMFLGELPEPLLTHKHFHvhlKIADLMQFDdkgnktniPDKERqIEALQLLFLILPPANRNLLKLLLDLLYQTAKKQDKN 251
Cdd:cd04384   80 KLYFRELPNPLLTYQLYE---KFSEAVSAA--------SDEER-LEKIHDVIQQLPPPHYRTLEFLMRHLSRLAKYCSIT 147

                        170
                 ....*....|....*....
gi 755563639 252 KMSAHNLALMFAPHVLWPK 270
Cdd:cd04384  148 NMHAKNLAIVWAPNLLRSK 166
RhoGAP_MgcRacGAP cd04382
RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 127-264 1.40e-08

RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin MKLP1, which is critical for the structure of the central spindle by promoting microtuble bundling. ii) after phosphorylation by aurora B MgcRacGAP becomes an effective regulator of RhoA and plays an important role in the assembly of the contractile ring and the initiation of cytokinesis. MgcRacGAP-like proteins contain a N-terminal C1-like domain, and a C-terminal RhoGAP domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239847  Cd Length: 193  Bit Score: 54.61  E-value: 1.40e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563639 127 LRVEGLFRVPGnSVRQ-QLLRDALNNGTDIdLDSGEFHSNDVATLLKMFLGELPEPLLTHKHFhvhlkiADLMqfddkgN 205
Cdd:cd04382   33 LTEEGLYRVSG-SEREvKALKEKFLRGKTV-PNLSKVDIHVICGCLKDFLRSLKEPLITFALW------KEFM------E 98

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 755563639 206 KTNIPDKERQIEALQLLFLILPPANRNLLKLLLDLLYQTAKKQDkNKMSAHNLALMFAP 264
Cdd:cd04382   99 AAEILDEDNSRAALYQAISELPQPNRDTLAFLILHLQRVAQSPE-CKMDINNLARVFGP 156
RhoGAP_SYD1 cd04379
RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 125-269 2.41e-08

RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in SYD-1_like proteins. Syd-1, first identified and best studied in C.elegans, has been shown to play an important role in neuronal development by specifying axonal properties. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239844  Cd Length: 207  Bit Score: 54.01  E-value: 2.41e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563639 125 KNLRVEGLFRVPGNSVRQQLLRDAL-NNGTDIDLDSGEFHSNDVAT-LLKMFLGELPEPLLTHKHFHVHLKIAdlmqfdd 202
Cdd:cd04379   32 RGLDVIGLYRLCGSAAKKKELRDAFeRNSAAVELSEELYPDINVITgVLKDYLRELPEPLITPQLYEMVLEAL------- 104

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755563639 203 kgnKTNIPDKERQIEALQLLFL-ILPPANRNLLKLLLDLLYQTAKKQDKNKMSAHNLALMFAPHVLWP 269
Cdd:cd04379  105 ---AVALPNDVQTNTHLTLSIIdCLPLSAKATLLLLLDHLSLVLSNSERNKMTPQNLAVCFGPVLMFC 169
RhoGAP_srGAP cd04383
RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 120-264 6.45e-08

RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an N-terminal FCH domain, a central RhoGAP domain and a C-terminal SH3 domain; this SH3 domain interacts with the intracellular proline-rich-tail of the Roundabout receptor (Robo). This interaction with Robo then activates the rhoGAP domain which in turn inhibits Cdc42 activity. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239848  Cd Length: 188  Bit Score: 52.42  E-value: 6.45e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563639 120 IEYLHKN-LRVEGLFRVPGNSVRQQLLRDALNNGTDIDLDSGEFHS-NDVATLLKMFLGELPEPLLTHKHFHvhlkiaDL 197
Cdd:cd04383   26 IRFINLYgLQHQGIFRVSGSQVEVNDIKNAFERGEDPLADDQNDHDiNSVAGVLKLYFRGLENPLFPKERFE------DL 99

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755563639 198 MqfdDKGNKTNIPDKERQIealQLLFLILPPANRNLLKLLLDLLYQTAKKQDKNKMSAHNLALMFAP 264
Cdd:cd04383  100 M---SCVKLENPTERVHQI---REILSTLPRSVIIVMRYLFAFLNHLSQFSDENMMDPYNLAICFGP 160
RhoGAP_KIAA1688 cd04389
RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 128-294 8.29e-07

RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239854  Cd Length: 187  Bit Score: 49.31  E-value: 8.29e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563639 128 RVEGLFRVPGNSVRQQLLRDALNNGtDIDLdSGEFHSNDVATLLKMFLGELPEPLLTHKHFhvhlkiadlmqfDDKGNKT 207
Cdd:cd04389   39 QTEGIFRVPGDIDEVNELKLRVDQW-DYPL-SGLEDPHVPASLLKLWLRELEEPLIPDALY------------QQCISAS 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563639 208 NIPDKerQIEALQLLflilPPANRNLLKLLLDLLYQTAKKQ--DKNKMSAHNLALMFAPHVLWPKNVTANDLQENIIKLN 285
Cdd:cd04389  105 EDPDK--AVEIVQKL----PIINRLVLCYLINFLQVFAQPEnvAHTKMDVSNLAMVFAPNILRCTSDDPRVIFENTRKEM 178


                 ....*....
gi 755563639 286 TGMAFMIKH 294
Cdd:cd04389  179 SFLRTLIEH 187
RhoGAP_OCRL1 cd04380
RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 116-270 2.67e-06

RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate 5-phosphatase domain and a C-terminal Rho GAP domain, this GAP domain lacks the catalytic residue and therefore maybe inactive. OCRL-like proteins are type II inositol polyphosphate 5-phosphatases that can hydrolyze lipid PI(4,5)P2 and PI(3,4,5)P3 and soluble Ins(1,4,5)P3 and Ins(1,3,4,5)P4, but their individual specificities vary. The functionality of the RhoGAP domain is still unclear. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239845  Cd Length: 220  Bit Score: 48.11  E-value: 2.67e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563639 116 IYQLIEYLHKN-LRVEGLFRVPGNSV----RQQLLRDALNNGTDiDLDSGEFHSndVATLLKMFLGELPEPLLThKHFHV 190
Cdd:cd04380   54 IWRLVDYLYTRgLAQEGLFEEPGLPSepgeLLAEIRDALDTGSP-FNSPGSAES--VAEALLLFLESLPDPIIP-YSLYE 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563639 191 HLKIADLMQFDDKgnktnipdkerqieaLQLLFLILPPANRNLLKLLLDLLYQTAKKQDKNKMSAHNLALMFAPHVLWPK 270
Cdd:cd04380  130 RLLEAVANNEEDK---------------RQVIRISLPPVHRNVFVYLCSFLRELLSESADRGLDENTLATIFGRVLLRDP 194
RhoGAP_myosin_IXA cd04406
RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 116-267 3.64e-06

RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXA. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239871  Cd Length: 186  Bit Score: 47.30  E-value: 3.64e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563639 116 IYQLIEYLHKN-LRVEGLFRVPGNSVRQQLLRDALNNGTD-IDLDSGEFHSndVATLLKMFLGELPEPLLTHKHFHVHLK 193
Cdd:cd04406   19 VEKLINYIEMHgLYTEGIYRKSGSTNKIKELRQGLDTDANsVNLDDYNIHV--IASVFKQWLRDLPNPLMTFELYEEFLR 96

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755563639 194 IADLMqfddkgnktnipDKERQIEALQLLFLILPPANRNLLKLLLDLLYQTAKKQDKNKMSAHNLALMFAPHVL 267
Cdd:cd04406   97 AMGLQ------------ERRETVRGVYSVIDQLSRTHLNTLERLIFHLVRIALQEETNRMSANALAIVFAPCIL 158
RhoGAP_BRCC3-like cd04405
RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 169-231 1.43e-05

RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of BRCC3-like proteins. This subgroup also contains two groups of closely related proteins, BRCC3 and DEPDC7, which both contain a C-terminal RhoGAP-like domain and an N-terminal DEP (Disheveled, Egl-10, and Pleckstrin) domain. The function(s) of BRCC3 and DEPDC7 are unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239870  Cd Length: 235  Bit Score: 46.17  E-value: 1.43e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755563639 169 TLLKMFlGELPEPLLTHKHFHVHLKIADLMQfddkGNKTnipdkERQIEALQLLFLILPPANR 231
Cdd:cd04405  111 TIAKYY-GQLKEPLLTFHLFDIFVGILELLG----NGKE-----EVALEALQLCLLLLPPASR 163
RhoGAP_fRGD2 cd04399
RhoGAP_fRGD2: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 135-185 4.48e-03

RhoGAP_fRGD2: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal RGD2-like proteins. Yeast Rgd2 is a GAP protein for Cdc42 and Rho5. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239864  Cd Length: 212  Bit Score: 38.47  E-value: 4.48e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 755563639 135 VPGNSVRQqlLRDALNNGTDIDLD---SGEFHSNDVATLLKMFLGELPEPLLTH 185
Cdd:cd04399   48 VSLKETHQ--LRNLLNKPKKPDKEviiLKKFEPSTVASVLKLYLLELPDSLIPH 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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