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Conserved domains on  [gi|767908243|ref|XP_011507423|]
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solute carrier family 26 member 9 isoform X1 [Homo sapiens]

Protein Classification

SLC26/SulP family anion transporter( domain architecture ID 12012049)

SLC26 (solute carrier 26)/SulP family anion transporter mediates the transport of anions such as bicarbonate, chloride, sulfate and/or oxalate; similar to mammalian chloride anion exchanger and Neurospora crassa sulfate permease 2

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PRK11660 super family cl46980
putative transporter; Provisional
1-472 4.45e-90

putative transporter; Provisional


The actual alignment was detected with superfamily member TIGR00815:

Pssm-ID: 481320 [Multi-domain]  Cd Length: 552  Bit Score: 291.93  E-value: 4.45e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908243    1 MAFALLANLPAVNGLYSSFFPLLTYFFLGGVHQMVPGTFAVISILVGNICLQLAPESKFQvfnnatnesyvdtaamEAER 80
Cdd:TIGR00815  33 IAYAKLAGLPPIYGLYTSFVPPIIYALFGSSRHIAIGPTASVSLLLGSLVQREGLQGLFD----------------DYIR 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908243   81 LHVSATLacLTAIIQMGLGFMQFGFVAIYLSESFIRGFMTAAGLQILISVLKYIFGLTIPSYTGPGSIVFTFIDickNLP 160
Cdd:TIGR00815  97 LAFTATL--LAGIFQVIMGLLRLGFLIEYLSHAVLVGFTAGAAITIGLSQLKGLLGLSIFVKTDILGVVISTWA---SLH 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908243  161 HTNIASLIFALISGAFLVLVKELNARYMHKIRFPIPTEMIVVVVATAISGGCKMpKKYHMQIVGEIQRGFPT--PVSPVV 238
Cdd:TIGR00815 172 QNNWCTLVIGLLFLLFLLATKELGKRNKKLLWAPAPAPLLVVVLATLIVTIGLH-DSQGVSIVGHIPQGLSFfpPITFTW 250
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908243  239 SQWKDMIGTAFSLAIVSYVINLAMGRTLANKHGYDVDSNQEMIALGCSNFFGSFFKIHVICCALSVTLAVDGAGGKSQVA 318
Cdd:TIGR00815 251 QHLPTLAPDAIAIAIVGLTESILTARVFAAMTGYEIDANKELVALGIANIVGSFFSCYPATGSLSRTAVNYKAGCKTQLS 330
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908243  319 SLCVSLVVMITMLVLGIYLYPLPKSVLGALIAVNLKNSLKqLTDPYYLWRKSKLDCCIWVVSFLSSFFLSLPYGVAVGVA 398
Cdd:TIGR00815 331 AIVMAIVVLLVLLVLAPLFYYIPLAALAAIIISAAVGLID-IRELYLLWKADKMDFVVWLGTFLGVVFTSIEIGLLVGVS 409
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767908243  399 FSVLVVVFQTQFRNGYALAQVMDTDIYVNPKTYNRAQDIQGIKIITYCSPLYFANSEIFRQKVIAKTGMDPQKV 472
Cdd:TIGR00815 410 LSAFFFILRVARPRAAVLGRIPGTEDYENIEQYPKAQTPPGILIFRVDGPLYFANAEDLKERLLKWLETLELDP 483
STAS_SulP_like_sulfate_transporter cd07042
Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, ...
573-641 2.16e-12

Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; The SulP family is a large and diverse family of anion transporters, with members from eubacteria, plants, fungi, and mammals. They contain 10 to 14 transmembrane helices which form the catalytic core of the protein and a C-terminal extension, the STAS (Sulphate Transporter and AntiSigma factor antagonist) domain which plays a role in the function and regulation of the transport activity. The STAS domain is found in the C-terminal region of sulphate transporters and bacterial anti-sigma factor antagonists. It has been suggested that this domain may have a general NTP binding function.


:

Pssm-ID: 132913 [Multi-domain]  Cd Length: 107  Bit Score: 63.80  E-value: 2.16e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767908243 573 FHTLILDMSGVSFVDLMGIKALAKLSSTYGKIGVKVFLVNIHAQVYNDISHGGVFEDgsLECKHVFPSI 641
Cdd:cd07042   41 LKVVILDLSAVNFIDSTAAEALEELVKDLRKRGVELYLAGLNPQVRELLERAGLLDE--IGEENFFPTL 107
 
Name Accession Description Interval E-value
sulP TIGR00815
high affinity sulphate transporter 1; The SulP family is a large and ubiquitous family with ...
1-472 4.45e-90

high affinity sulphate transporter 1; The SulP family is a large and ubiquitous family with over 30 sequenced members derived from bacteria, fungi, plants and animals. Many organisms including Bacillus subtilis, Synechocystis sp, Saccharomyces cerevisiae, Arabidopsis thaliana and Caenorhabditis elegans possess multiple SulP family paralogues. Many of these proteins are functionally characterized, and all are sulfate uptake transporters. Some transport their substrate with high affinities, while others transport it with relatively low affinities. Most function by SO42- :H+symport, but SO42- :HCO3- antiport has been reported for the rat protein (spP45380). The bacterial proteins vary in size from 434 residues to 566 residues with one exception, a Mycobacterium tuberculosis protein with 784 residues. The eukaryotic proteins vary in size from 611 residues to 893 residues with one exception, a protein designated "early nodulin 70 protein" from Glycine max which is reported to be of 485 residues. Thus, the eukaryotic proteins are almost without exception larger than the prokaryotic proteins. These proteins exhibit 10-13 putative transmembrane a-helical spanners (TMSs) depending on the protein. The phylogenetic tree for the SulP family reveals five principal branches. Three of these are bacterial specific as follows: one bears a single protein from M. tuberculosis; a second bears two proteins, one from M. tuberculosis, the other from Synechocystis sp, and the third bears all remaining prokaryotic proteins. The remaining two clusters bear only eukaryotic proteins with the animal proteins all localized to one branch and the plant and fungal proteins localized to the other. The generalized transport reactions catalyzed by SulP family proteins are: (1) SO42- (out) + nH+ (out) --> SO42- (in) + nH+ (in). (2) SO42- (out) + nHCO3- (in) SO42- (in) + nHCO3- (out). [Transport and binding proteins, Anions]


Pssm-ID: 273284 [Multi-domain]  Cd Length: 552  Bit Score: 291.93  E-value: 4.45e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908243    1 MAFALLANLPAVNGLYSSFFPLLTYFFLGGVHQMVPGTFAVISILVGNICLQLAPESKFQvfnnatnesyvdtaamEAER 80
Cdd:TIGR00815  33 IAYAKLAGLPPIYGLYTSFVPPIIYALFGSSRHIAIGPTASVSLLLGSLVQREGLQGLFD----------------DYIR 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908243   81 LHVSATLacLTAIIQMGLGFMQFGFVAIYLSESFIRGFMTAAGLQILISVLKYIFGLTIPSYTGPGSIVFTFIDickNLP 160
Cdd:TIGR00815  97 LAFTATL--LAGIFQVIMGLLRLGFLIEYLSHAVLVGFTAGAAITIGLSQLKGLLGLSIFVKTDILGVVISTWA---SLH 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908243  161 HTNIASLIFALISGAFLVLVKELNARYMHKIRFPIPTEMIVVVVATAISGGCKMpKKYHMQIVGEIQRGFPT--PVSPVV 238
Cdd:TIGR00815 172 QNNWCTLVIGLLFLLFLLATKELGKRNKKLLWAPAPAPLLVVVLATLIVTIGLH-DSQGVSIVGHIPQGLSFfpPITFTW 250
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908243  239 SQWKDMIGTAFSLAIVSYVINLAMGRTLANKHGYDVDSNQEMIALGCSNFFGSFFKIHVICCALSVTLAVDGAGGKSQVA 318
Cdd:TIGR00815 251 QHLPTLAPDAIAIAIVGLTESILTARVFAAMTGYEIDANKELVALGIANIVGSFFSCYPATGSLSRTAVNYKAGCKTQLS 330
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908243  319 SLCVSLVVMITMLVLGIYLYPLPKSVLGALIAVNLKNSLKqLTDPYYLWRKSKLDCCIWVVSFLSSFFLSLPYGVAVGVA 398
Cdd:TIGR00815 331 AIVMAIVVLLVLLVLAPLFYYIPLAALAAIIISAAVGLID-IRELYLLWKADKMDFVVWLGTFLGVVFTSIEIGLLVGVS 409
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767908243  399 FSVLVVVFQTQFRNGYALAQVMDTDIYVNPKTYNRAQDIQGIKIITYCSPLYFANSEIFRQKVIAKTGMDPQKV 472
Cdd:TIGR00815 410 LSAFFFILRVARPRAAVLGRIPGTEDYENIEQYPKAQTPPGILIFRVDGPLYFANAEDLKERLLKWLETLELDP 483
Sulfate_transp pfam00916
Sulfate permease family; This family of integral membrane proteins are known as the Sulfate ...
1-379 7.72e-90

Sulfate permease family; This family of integral membrane proteins are known as the Sulfate Permease (SulP) family. SulP is a large family found in all domains of life. Although sulfate is a commonly transported ion there are many other activities in this family. See the TCDB description for a comprehensive summary.


Pssm-ID: 459995 [Multi-domain]  Cd Length: 379  Bit Score: 285.30  E-value: 7.72e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908243    1 MAFALLANLPAVNGLYSSFFPLLTYFFLGGVHQMVPGTFAVISILVGNICLQLApeskfqvfnNATNESYvdtaameaer 80
Cdd:pfam00916  20 LAYAILAGLPPIYGLYSSFVPGFVYALFGTSRHLAIGPVAVLSLMVGAAIAKLA---------AKDPELG---------- 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908243   81 LHVSATLACLTAIIQMGLGFMQFGFVAIYLSESFIRGFMTAAGLQILISVLKYIFGLTIpsYTGPGSIVFTFIDICKNLP 160
Cdd:pfam00916  81 IALAFTLTFLAGIIQLALGLLRLGFLVTFLSHAVISGFMGGAAIVILLSQLKVLLGLTN--FSGPGYVVSVLQSLFTNLD 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908243  161 HTNIASLIFALISGAFLVLVKELNARYMHKIRFPIPTEMIVVVVATAISGGCKMPKKYHMQIVGEIQRGFPTPVSPVVSq 240
Cdd:pfam00916 159 KVNLATLVLGLLVLVILLFTKELGKKYKKLFWIPAPAPLVAVVLATLVSAIFDLLRRYGVKIVGEIPSGLPPFSLPKFS- 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908243  241 WKDM---IGTAFSLAIVSYVINLAMGRTLANKHGYDVDSNQEMIALGCSNFFGSFFKIHVICCALSVTLAVDGAGGKSQV 317
Cdd:pfam00916 238 WSLLsalLPDALAIAIVGLLEAIAISKSFAKKKGYEVDSNQELVALGFANILSGLFGGYPATGAFSRSAVNIKAGAKTPL 317
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767908243  318 ASLCVSLVVMITMLVLGIYLYPLPKSVLGALIAVNLKnSLKQLTDPYYLWRKSKLDCCIWVV 379
Cdd:pfam00916 318 SGIIMAVIVLLVLLFLTPLFAYIPKAVLAAIIIVAGK-GLIDYRELKHLWRLSKLDFLIWLA 378
SUL1 COG0659
Sulfate permease or related transporter, MFS superfamily [Inorganic ion transport and ...
1-653 7.42e-66

Sulfate permease or related transporter, MFS superfamily [Inorganic ion transport and metabolism];


Pssm-ID: 440424 [Multi-domain]  Cd Length: 529  Bit Score: 226.53  E-value: 7.42e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908243   1 MAFALLANLPAVNGLYSSFFPLLTYFFLGGVHQMVPGTFAVISILVGNIclqLAPESKFQVFnnatnesyvdtaameaer 80
Cdd:COG0659   26 LAFAIAAGLPPEAGLYAAIVGGIVYALFGGSRLLISGPTAALAVVVAAA---VAPLGSLALL------------------ 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908243  81 lhvsATLACLTAIIQMGLGFMQFGFVAIYLSESFIRGFMTAAGLQILISVLKYIFGLTIPSytgpGSIVFTFIDICKNLP 160
Cdd:COG0659   85 ----LAATLLAGVLQLLLGLLRLGRLARFIPRPVIVGFLAGIAILIILGQLPHLLGLPAPG----GSFLEKLAALLAALG 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908243 161 HTNIASLIFALISGAFLVLVKelnaRYMHKirfpIPTEMIVVVVATAISGGCKMPkkyhMQIVGEIQRGFPTPVSPVVS- 239
Cdd:COG0659  157 EINPPTLALGLLTLAILLLLP----RLLKR----IPGPLVAVVLGTLLVWLLGLD----VATVGEIPSGLPSFSLPDFSl 224
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908243 240 -QWKDMIGTAFSLAIVSYVINLAMGRTLANKHGYDVDSNQEMIALGCSNFFGSFFKIHVICCALSVTLAVDGAGGKSQVA 318
Cdd:COG0659  225 eTLRALLPPALTIALVGSIESLLTARAVDAMTGTRSDPNRELIAQGLANIASGLFGGLPVTGSISRSAVNVKAGARTRLS 304
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908243 319 SLCVSLVVMITMLVLGIYLYPLPKSVLGALI---AVNL--KNSLKQltdpyyLWRKSKLDCCIWVVSFLSSFFLSLPYGV 393
Cdd:COG0659  305 GIVHALFLLLVLLFLAPLLAYIPLAALAAILivvGIGLidWRSFRR------LWRAPRSDFLVMLVTFLVTVFTDLLIGV 378
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908243 394 AVGVAFSVLVVVFQTqFRNGYALAQVMDTDiYVNPKTYNRAQDIQGIKIITYCSPLYFANSEIFRQKViaktgmdpqkvl 473
Cdd:COG0659  379 LVGVLLSLLLFLRRV-SRPHVVVLRVPGTH-FRNVERHPEAETGPGVLVYRLDGPLFFGNAERLKERL------------ 444
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908243 474 lakqkylkkqekrrmrptqqrrslfmktktvslqelqqdfenapptdpnnnqtpangtsvsyitfspdssspAQSEPPAs 553
Cdd:COG0659  445 ------------------------------------------------------------------------DALAPDP- 451
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908243 554 aeapgepsdmlasvppfvtfHTLILDMSGVSFVDLMGIKALAKLSSTYGKIGVKVFLVNIHAQVYNDISHGGVFEDGSLE 633
Cdd:COG0659  452 --------------------RVVILDLSAVPFIDATALEALEELAERLRARGITLELAGLKPPVRDLLERAGLLDELGEE 511
                        650       660
                 ....*....|....*....|
gi 767908243 634 ckHVFPSIHDAVLFAQANAR 653
Cdd:COG0659  512 --RVFPDLDEALEAAEERAE 529
STAS_SulP_like_sulfate_transporter cd07042
Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, ...
573-641 2.16e-12

Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; The SulP family is a large and diverse family of anion transporters, with members from eubacteria, plants, fungi, and mammals. They contain 10 to 14 transmembrane helices which form the catalytic core of the protein and a C-terminal extension, the STAS (Sulphate Transporter and AntiSigma factor antagonist) domain which plays a role in the function and regulation of the transport activity. The STAS domain is found in the C-terminal region of sulphate transporters and bacterial anti-sigma factor antagonists. It has been suggested that this domain may have a general NTP binding function.


Pssm-ID: 132913 [Multi-domain]  Cd Length: 107  Bit Score: 63.80  E-value: 2.16e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767908243 573 FHTLILDMSGVSFVDLMGIKALAKLSSTYGKIGVKVFLVNIHAQVYNDISHGGVFEDgsLECKHVFPSI 641
Cdd:cd07042   41 LKVVILDLSAVNFIDSTAAEALEELVKDLRKRGVELYLAGLNPQVRELLERAGLLDE--IGEENFFPTL 107
STAS pfam01740
STAS domain; The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is ...
574-644 1.15e-11

STAS domain; The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is found in the C terminal region of Sulphate transporters and bacterial antisigma factor antagonists. It has been suggested that this domain may have a general NTP binding function.


Pssm-ID: 426404 [Multi-domain]  Cd Length: 106  Bit Score: 61.86  E-value: 1.15e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767908243  574 HTLILDMSGVSFVDLMGIKALAKLSSTYGKIGVKVFLVNIHAQVYNDISHGGVFEDGsleckHVFPSIHDA 644
Cdd:pfam01740  41 KHVVLDLSAVPFIDSSGLGALEELYKELRRRGVELVLVGPSPEVARTLEKTGLDDII-----KIFPTVAEA 106
PRK11660 PRK11660
putative transporter; Provisional
85-351 1.35e-08

putative transporter; Provisional


Pssm-ID: 183265 [Multi-domain]  Cd Length: 568  Bit Score: 58.04  E-value: 1.35e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908243  85 ATLacLTAIIQMGLGFMQFGFVAIYLSESFIRGFmtAAGLQILISVL--KYIFGLTIPSytGPGSIVFTFIDICKNLPHT 162
Cdd:PRK11660 108 ATL--MSGIILILMGLARLGRLIEYIPLSVTLGF--TSGIGIVIATLqiKDFFGLQMAH--VPEHYLEKVGALFQALPTI 181
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908243 163 NIASLIFALISGAFLVLvkelnaryMHKIRFPIPTEMIVVVVATAISGGCKM--------PKKYHMQIV-GEIQRGFPtP 233
Cdd:PRK11660 182 NWGDALIGIVTLGVLIL--------WPRLKIRLPGHLPALLAGTAVMGVLNLlgghvatiGSRFHYVLAdGSQGNGIP-P 252
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908243 234 V---------------SPVVSQW---KDMIGTAFSLAIVSYVINLAMGRTLANKHGYDVDSNQEMIALGCSNFFGSFFKI 295
Cdd:PRK11660 253 LlpqfvlpwnlpgadgQPFTLSWdliRALLPAAFSMAMLGAIESLLCAVVLDGMTGTKHSANSELVGQGLGNIVAPFFGG 332
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767908243 296 HVICCALSVTLAVDGAGGKSQVASLCVSLVVMITMLVLGIYLYPLPKSVLGALIAV 351
Cdd:PRK11660 333 ITATAAIARSAANVRAGATSPISAVIHALLVLLALLVLAPLLSYLPLSAMAALLLM 388
SpoIIAA COG1366
Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) [Signal transduction ...
574-617 2.94e-06

Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) [Signal transduction mechanisms];


Pssm-ID: 440977 [Multi-domain]  Cd Length: 93  Bit Score: 46.00  E-value: 2.94e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 767908243 574 HTLILDMSGVSFVDLMGIKALAKLSSTYGKIGVKVFLVNIHAQV 617
Cdd:COG1366   40 RRVVLDLSGVTFIDSSGLGALLSLAKAARLLGGRLVLVGVSPAV 83
 
Name Accession Description Interval E-value
sulP TIGR00815
high affinity sulphate transporter 1; The SulP family is a large and ubiquitous family with ...
1-472 4.45e-90

high affinity sulphate transporter 1; The SulP family is a large and ubiquitous family with over 30 sequenced members derived from bacteria, fungi, plants and animals. Many organisms including Bacillus subtilis, Synechocystis sp, Saccharomyces cerevisiae, Arabidopsis thaliana and Caenorhabditis elegans possess multiple SulP family paralogues. Many of these proteins are functionally characterized, and all are sulfate uptake transporters. Some transport their substrate with high affinities, while others transport it with relatively low affinities. Most function by SO42- :H+symport, but SO42- :HCO3- antiport has been reported for the rat protein (spP45380). The bacterial proteins vary in size from 434 residues to 566 residues with one exception, a Mycobacterium tuberculosis protein with 784 residues. The eukaryotic proteins vary in size from 611 residues to 893 residues with one exception, a protein designated "early nodulin 70 protein" from Glycine max which is reported to be of 485 residues. Thus, the eukaryotic proteins are almost without exception larger than the prokaryotic proteins. These proteins exhibit 10-13 putative transmembrane a-helical spanners (TMSs) depending on the protein. The phylogenetic tree for the SulP family reveals five principal branches. Three of these are bacterial specific as follows: one bears a single protein from M. tuberculosis; a second bears two proteins, one from M. tuberculosis, the other from Synechocystis sp, and the third bears all remaining prokaryotic proteins. The remaining two clusters bear only eukaryotic proteins with the animal proteins all localized to one branch and the plant and fungal proteins localized to the other. The generalized transport reactions catalyzed by SulP family proteins are: (1) SO42- (out) + nH+ (out) --> SO42- (in) + nH+ (in). (2) SO42- (out) + nHCO3- (in) SO42- (in) + nHCO3- (out). [Transport and binding proteins, Anions]


Pssm-ID: 273284 [Multi-domain]  Cd Length: 552  Bit Score: 291.93  E-value: 4.45e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908243    1 MAFALLANLPAVNGLYSSFFPLLTYFFLGGVHQMVPGTFAVISILVGNICLQLAPESKFQvfnnatnesyvdtaamEAER 80
Cdd:TIGR00815  33 IAYAKLAGLPPIYGLYTSFVPPIIYALFGSSRHIAIGPTASVSLLLGSLVQREGLQGLFD----------------DYIR 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908243   81 LHVSATLacLTAIIQMGLGFMQFGFVAIYLSESFIRGFMTAAGLQILISVLKYIFGLTIPSYTGPGSIVFTFIDickNLP 160
Cdd:TIGR00815  97 LAFTATL--LAGIFQVIMGLLRLGFLIEYLSHAVLVGFTAGAAITIGLSQLKGLLGLSIFVKTDILGVVISTWA---SLH 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908243  161 HTNIASLIFALISGAFLVLVKELNARYMHKIRFPIPTEMIVVVVATAISGGCKMpKKYHMQIVGEIQRGFPT--PVSPVV 238
Cdd:TIGR00815 172 QNNWCTLVIGLLFLLFLLATKELGKRNKKLLWAPAPAPLLVVVLATLIVTIGLH-DSQGVSIVGHIPQGLSFfpPITFTW 250
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908243  239 SQWKDMIGTAFSLAIVSYVINLAMGRTLANKHGYDVDSNQEMIALGCSNFFGSFFKIHVICCALSVTLAVDGAGGKSQVA 318
Cdd:TIGR00815 251 QHLPTLAPDAIAIAIVGLTESILTARVFAAMTGYEIDANKELVALGIANIVGSFFSCYPATGSLSRTAVNYKAGCKTQLS 330
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908243  319 SLCVSLVVMITMLVLGIYLYPLPKSVLGALIAVNLKNSLKqLTDPYYLWRKSKLDCCIWVVSFLSSFFLSLPYGVAVGVA 398
Cdd:TIGR00815 331 AIVMAIVVLLVLLVLAPLFYYIPLAALAAIIISAAVGLID-IRELYLLWKADKMDFVVWLGTFLGVVFTSIEIGLLVGVS 409
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767908243  399 FSVLVVVFQTQFRNGYALAQVMDTDIYVNPKTYNRAQDIQGIKIITYCSPLYFANSEIFRQKVIAKTGMDPQKV 472
Cdd:TIGR00815 410 LSAFFFILRVARPRAAVLGRIPGTEDYENIEQYPKAQTPPGILIFRVDGPLYFANAEDLKERLLKWLETLELDP 483
Sulfate_transp pfam00916
Sulfate permease family; This family of integral membrane proteins are known as the Sulfate ...
1-379 7.72e-90

Sulfate permease family; This family of integral membrane proteins are known as the Sulfate Permease (SulP) family. SulP is a large family found in all domains of life. Although sulfate is a commonly transported ion there are many other activities in this family. See the TCDB description for a comprehensive summary.


Pssm-ID: 459995 [Multi-domain]  Cd Length: 379  Bit Score: 285.30  E-value: 7.72e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908243    1 MAFALLANLPAVNGLYSSFFPLLTYFFLGGVHQMVPGTFAVISILVGNICLQLApeskfqvfnNATNESYvdtaameaer 80
Cdd:pfam00916  20 LAYAILAGLPPIYGLYSSFVPGFVYALFGTSRHLAIGPVAVLSLMVGAAIAKLA---------AKDPELG---------- 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908243   81 LHVSATLACLTAIIQMGLGFMQFGFVAIYLSESFIRGFMTAAGLQILISVLKYIFGLTIpsYTGPGSIVFTFIDICKNLP 160
Cdd:pfam00916  81 IALAFTLTFLAGIIQLALGLLRLGFLVTFLSHAVISGFMGGAAIVILLSQLKVLLGLTN--FSGPGYVVSVLQSLFTNLD 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908243  161 HTNIASLIFALISGAFLVLVKELNARYMHKIRFPIPTEMIVVVVATAISGGCKMPKKYHMQIVGEIQRGFPTPVSPVVSq 240
Cdd:pfam00916 159 KVNLATLVLGLLVLVILLFTKELGKKYKKLFWIPAPAPLVAVVLATLVSAIFDLLRRYGVKIVGEIPSGLPPFSLPKFS- 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908243  241 WKDM---IGTAFSLAIVSYVINLAMGRTLANKHGYDVDSNQEMIALGCSNFFGSFFKIHVICCALSVTLAVDGAGGKSQV 317
Cdd:pfam00916 238 WSLLsalLPDALAIAIVGLLEAIAISKSFAKKKGYEVDSNQELVALGFANILSGLFGGYPATGAFSRSAVNIKAGAKTPL 317
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767908243  318 ASLCVSLVVMITMLVLGIYLYPLPKSVLGALIAVNLKnSLKQLTDPYYLWRKSKLDCCIWVV 379
Cdd:pfam00916 318 SGIIMAVIVLLVLLFLTPLFAYIPKAVLAAIIIVAGK-GLIDYRELKHLWRLSKLDFLIWLA 378
SUL1 COG0659
Sulfate permease or related transporter, MFS superfamily [Inorganic ion transport and ...
1-653 7.42e-66

Sulfate permease or related transporter, MFS superfamily [Inorganic ion transport and metabolism];


Pssm-ID: 440424 [Multi-domain]  Cd Length: 529  Bit Score: 226.53  E-value: 7.42e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908243   1 MAFALLANLPAVNGLYSSFFPLLTYFFLGGVHQMVPGTFAVISILVGNIclqLAPESKFQVFnnatnesyvdtaameaer 80
Cdd:COG0659   26 LAFAIAAGLPPEAGLYAAIVGGIVYALFGGSRLLISGPTAALAVVVAAA---VAPLGSLALL------------------ 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908243  81 lhvsATLACLTAIIQMGLGFMQFGFVAIYLSESFIRGFMTAAGLQILISVLKYIFGLTIPSytgpGSIVFTFIDICKNLP 160
Cdd:COG0659   85 ----LAATLLAGVLQLLLGLLRLGRLARFIPRPVIVGFLAGIAILIILGQLPHLLGLPAPG----GSFLEKLAALLAALG 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908243 161 HTNIASLIFALISGAFLVLVKelnaRYMHKirfpIPTEMIVVVVATAISGGCKMPkkyhMQIVGEIQRGFPTPVSPVVS- 239
Cdd:COG0659  157 EINPPTLALGLLTLAILLLLP----RLLKR----IPGPLVAVVLGTLLVWLLGLD----VATVGEIPSGLPSFSLPDFSl 224
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908243 240 -QWKDMIGTAFSLAIVSYVINLAMGRTLANKHGYDVDSNQEMIALGCSNFFGSFFKIHVICCALSVTLAVDGAGGKSQVA 318
Cdd:COG0659  225 eTLRALLPPALTIALVGSIESLLTARAVDAMTGTRSDPNRELIAQGLANIASGLFGGLPVTGSISRSAVNVKAGARTRLS 304
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908243 319 SLCVSLVVMITMLVLGIYLYPLPKSVLGALI---AVNL--KNSLKQltdpyyLWRKSKLDCCIWVVSFLSSFFLSLPYGV 393
Cdd:COG0659  305 GIVHALFLLLVLLFLAPLLAYIPLAALAAILivvGIGLidWRSFRR------LWRAPRSDFLVMLVTFLVTVFTDLLIGV 378
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908243 394 AVGVAFSVLVVVFQTqFRNGYALAQVMDTDiYVNPKTYNRAQDIQGIKIITYCSPLYFANSEIFRQKViaktgmdpqkvl 473
Cdd:COG0659  379 LVGVLLSLLLFLRRV-SRPHVVVLRVPGTH-FRNVERHPEAETGPGVLVYRLDGPLFFGNAERLKERL------------ 444
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908243 474 lakqkylkkqekrrmrptqqrrslfmktktvslqelqqdfenapptdpnnnqtpangtsvsyitfspdssspAQSEPPAs 553
Cdd:COG0659  445 ------------------------------------------------------------------------DALAPDP- 451
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908243 554 aeapgepsdmlasvppfvtfHTLILDMSGVSFVDLMGIKALAKLSSTYGKIGVKVFLVNIHAQVYNDISHGGVFEDGSLE 633
Cdd:COG0659  452 --------------------RVVILDLSAVPFIDATALEALEELAERLRARGITLELAGLKPPVRDLLERAGLLDELGEE 511
                        650       660
                 ....*....|....*....|
gi 767908243 634 ckHVFPSIHDAVLFAQANAR 653
Cdd:COG0659  512 --RVFPDLDEALEAAEERAE 529
STAS_SulP_like_sulfate_transporter cd07042
Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, ...
573-641 2.16e-12

Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; The SulP family is a large and diverse family of anion transporters, with members from eubacteria, plants, fungi, and mammals. They contain 10 to 14 transmembrane helices which form the catalytic core of the protein and a C-terminal extension, the STAS (Sulphate Transporter and AntiSigma factor antagonist) domain which plays a role in the function and regulation of the transport activity. The STAS domain is found in the C-terminal region of sulphate transporters and bacterial anti-sigma factor antagonists. It has been suggested that this domain may have a general NTP binding function.


Pssm-ID: 132913 [Multi-domain]  Cd Length: 107  Bit Score: 63.80  E-value: 2.16e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767908243 573 FHTLILDMSGVSFVDLMGIKALAKLSSTYGKIGVKVFLVNIHAQVYNDISHGGVFEDgsLECKHVFPSI 641
Cdd:cd07042   41 LKVVILDLSAVNFIDSTAAEALEELVKDLRKRGVELYLAGLNPQVRELLERAGLLDE--IGEENFFPTL 107
STAS pfam01740
STAS domain; The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is ...
574-644 1.15e-11

STAS domain; The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is found in the C terminal region of Sulphate transporters and bacterial antisigma factor antagonists. It has been suggested that this domain may have a general NTP binding function.


Pssm-ID: 426404 [Multi-domain]  Cd Length: 106  Bit Score: 61.86  E-value: 1.15e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767908243  574 HTLILDMSGVSFVDLMGIKALAKLSSTYGKIGVKVFLVNIHAQVYNDISHGGVFEDGsleckHVFPSIHDA 644
Cdd:pfam01740  41 KHVVLDLSAVPFIDSSGLGALEELYKELRRRGVELVLVGPSPEVARTLEKTGLDDII-----KIFPTVAEA 106
PRK11660 PRK11660
putative transporter; Provisional
85-351 1.35e-08

putative transporter; Provisional


Pssm-ID: 183265 [Multi-domain]  Cd Length: 568  Bit Score: 58.04  E-value: 1.35e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908243  85 ATLacLTAIIQMGLGFMQFGFVAIYLSESFIRGFmtAAGLQILISVL--KYIFGLTIPSytGPGSIVFTFIDICKNLPHT 162
Cdd:PRK11660 108 ATL--MSGIILILMGLARLGRLIEYIPLSVTLGF--TSGIGIVIATLqiKDFFGLQMAH--VPEHYLEKVGALFQALPTI 181
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908243 163 NIASLIFALISGAFLVLvkelnaryMHKIRFPIPTEMIVVVVATAISGGCKM--------PKKYHMQIV-GEIQRGFPtP 233
Cdd:PRK11660 182 NWGDALIGIVTLGVLIL--------WPRLKIRLPGHLPALLAGTAVMGVLNLlgghvatiGSRFHYVLAdGSQGNGIP-P 252
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908243 234 V---------------SPVVSQW---KDMIGTAFSLAIVSYVINLAMGRTLANKHGYDVDSNQEMIALGCSNFFGSFFKI 295
Cdd:PRK11660 253 LlpqfvlpwnlpgadgQPFTLSWdliRALLPAAFSMAMLGAIESLLCAVVLDGMTGTKHSANSELVGQGLGNIVAPFFGG 332
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767908243 296 HVICCALSVTLAVDGAGGKSQVASLCVSLVVMITMLVLGIYLYPLPKSVLGALIAV 351
Cdd:PRK11660 333 ITATAAIARSAANVRAGATSPISAVIHALLVLLALLVLAPLLSYLPLSAMAALLLM 388
SpoIIAA COG1366
Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) [Signal transduction ...
574-617 2.94e-06

Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) [Signal transduction mechanisms];


Pssm-ID: 440977 [Multi-domain]  Cd Length: 93  Bit Score: 46.00  E-value: 2.94e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 767908243 574 HTLILDMSGVSFVDLMGIKALAKLSSTYGKIGVKVFLVNIHAQV 617
Cdd:COG1366   40 RRVVLDLSGVTFIDSSGLGALLSLAKAARLLGGRLVLVGVSPAV 83
STAS_anti-anti-sigma_factors cd07043
Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key ...
573-617 2.22e-05

Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.


Pssm-ID: 132914 [Multi-domain]  Cd Length: 99  Bit Score: 43.66  E-value: 2.22e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 767908243 573 FHTLILDMSGVSFVDLMGIKALAKLSSTYGKIGVKVFLVNIHAQV 617
Cdd:cd07043   38 PRRLVLDLSGVTFIDSSGLGVLLGAYKRARAAGGRLVLVNVSPAV 82
STAS_RsbR_RsbS_like cd07041
Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex ...
574-617 3.51e-03

Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; The STAS (Sulphate Transporter and Anti-Sigma factor antagonist) domain of proteins related to RsbS and RsbR which are part of the "stressosome" complex that plays an important role in the regulation of the bacterial stress activated alternative sigma factor sigma-B. During stress conditions RsbS and RsbR are phosphorylated which leads to the release of RsbT, an activator of of the RsbU phosphatase, which in turn activates RsbV which leads to the release and activation of sigma factor B. RsbS is a single domain protein (STAS domain), while RsbR-like proteins have a well-conserved C-terminal STATS domain and a variable N-terminal domain. The STAS domain is also found in the C- terminal region of sulphate transporters and anti-anti-sigma factors.


Pssm-ID: 132912  Cd Length: 109  Bit Score: 37.82  E-value: 3.51e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 767908243 574 HTLILDMSGVSFVDLMGIKALAKLSSTYGKIGVKVFLVNIHAQV 617
Cdd:cd07041   42 RGVIIDLTGVPVIDSAVARHLLRLARALRLLGARTILTGIRPEV 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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