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Conserved domains on  [gi|767926067|ref|XP_011510861|]
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myosin-15 isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MYSc_Myh15_mammals cd14929
class II myosin heavy chain 15, motor domain; Myosin motor domain of sarcomeric myosin heavy ...
117-778 0e+00

class II myosin heavy chain 15, motor domain; Myosin motor domain of sarcomeric myosin heavy chain 15 in mammals (also called KIAA1000) . MYH15 is a slow-twitch myosin. Myh15 is a ventricular myosin heavy chain. Myh15 is absent in embryonic and fetal muscles and is found in orbital layer of extraocular muscles at birth. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


:

Pssm-ID: 276892 [Multi-domain]  Cd Length: 662  Bit Score: 1430.14  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  117 ASVLHTLKRRYGQWMIYTYSGLFCVTINPYKWLPVYQKEVMAAYKGKRRSEAPPHIFAVANNAFQDMLHNRENQSILFTG 196
Cdd:cd14929     1 ASVLHTLRRRYDHWMIYTYSGLFCVTINPYKWLPVYQKEVMAAYKGKRRSEAPPHIFAVANNAFQDMLHNRENQSILFTG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  197 ESGAGKTVNSKHIIQYFATIAAMIESRKKQGALEDQIMQANTILEAFGNAKTLRNDNSSRFGKFIRMHFGARGMLSSVDI 276
Cdd:cd14929    81 ESGAGKTVNTKHIIQYFATIAAMIESKKKLGALEDQIMQANPVLEAFGNAKTLRNDNSSRFGKFIRMHFGARGMLSSADI 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  277 DIYLLEKSRVIFQQAGERNYHIFYQILSGQKELHDLLLVSANPSDFHFCSCGAVTVESLDDAEELLATEQAMDILGFLPD 356
Cdd:cd14929   161 DIYLLEKSRVIFQQPGERNYHIFYQILSGKKELRDLLLVSANPSDFHFCSCGAVAVESLDDAEELLATEQAMDILGFLPD 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  357 EKYGCYKLTGAIMHFGNMKFKQKPREEQLEADGTENADKAAFLMGINSSELVKCLIHPRIKVGNEYVTRGQTIEQVTCAV 436
Cdd:cd14929   241 EKYGCYKLTGAIMHFGNMKFKQKPREEQLEADGTENADKAAFLMGINSSELVKGLIHPRIKVGNEYVTRSQNIEQVTYAV 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  437 GALSKSMYERMFKWLVARINRALDAKLSRQFFIGILDITGFEILEYNSLEQLCINFTNEKLQQFFNWHMFVLEQEEYKKE 516
Cdd:cd14929   321 GALSKSIYERMFKWLVARINRVLDAKLSRQFFIGILDITGFEILDYNSLEQLCINFTNEKLQQFFNQHMFVLEQEEYRKE 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  517 SIEWVSIGFGLDLQACIDLIEKPMGILSILEEECMFPKATDLTFKTKLFDNHFGKSVHLQKPKPDKKKFEAHFELVHYAG 596
Cdd:cd14929   401 GIDWVSIDFGLDLQACIDLIEKPMGIFSILEEECMFPKATDLTFKTKLFDNHFGKSVHFQKPKPDKKKFEAHFELVHYAG 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  597 VVPYNISGWLEKNKDLLNETVVAVFQKSSNRLLASLFENYMSTDSAIPFGEKKRKKGASFQTVASLHKENLNKLMTNLKS 676
Cdd:cd14929   481 VVPYNISGWLEKNKDLLNETVVAVFQKSSNRLLASLFENYISTDSAIQFGEKKRKKGASFQTVASLHKENLNKLMTNLKS 560
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  677 TAPHFVRCINPNVNKIPGILDPYLVLQQLRCNGVLEGTRICREGFPNRLQYADFKQRYCILNPRTFPKSKFVSSRKAAEE 756
Cdd:cd14929   561 TAPHFVRCINPNVNKIPGVLDPYLVLQQLRCNGVLEGIRICREGFPNRLLYADFKQRYCILNPRTFPKSKFVSSRKAAEE 640
                         650       660
                  ....*....|....*....|..
gi 767926067  757 LLGSLEIDHTQYRFGITKVFFK 778
Cdd:cd14929   641 LLGSLEIDHTQYRFGITKVFFK 662
COG5022 super family cl34868
Myosin heavy chain [General function prediction only];
53-1460 0e+00

Myosin heavy chain [General function prediction only];


The actual alignment was detected with superfamily member COG5022:

Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 817.39  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   53 KCWIPDGENAYIEAEVKGSEDDGTVIVETAD---GESLSIKEDKIQQ--MNPPEFEMIEDMAMLTHLNEASVLHTLKRRY 127
Cdd:COG5022    11 GCWIPDEEKGWIWAEIIKEAFNKGKVTEEGKkedGESVSVKKKVLGNdrIKLPKFDGVDDLTELSYLNEPAVLHNLEKRY 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  128 GQWMIYTYSGLFCVTINPYKWLPVYQKEVMAAYKGKRRSEAPPHIFAVANNAFQDMLHNRENQSILFTGESGAGKTVNSK 207
Cdd:COG5022    91 NNGQIYTYSGLVLIAVNPYRDLGIYTDDIIQSYSGKNRLELEPHVFAIAEEAYRNLLSEKENQTIIISGESGAGKTENAK 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  208 HIIQYFATIAAMIESRKKQgaLEDQIMQANTILEAFGNAKTLRNDNSSRFGKFIRMHFGARGMLSSVDIDIYLLEKSRVI 287
Cdd:COG5022   171 RIMQYLASVTSSSTVEISS--IEKQILATNPILEAFGNAKTVRNDNSSRFGKYIKIEFDENGEICGAKIETYLLEKSRVV 248
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  288 FQQAGERNYHIFYQILSGQKELHDLLLVSANPSDFHFCSCGAVT-VESLDDAEELLATEQAMDILGFLPDEKYGCYKLTG 366
Cdd:COG5022   249 HQNKNERNYHIFYQLLAGDPEELKKLLLLQNPKDYIYLSQGGCDkIDGIDDAKEFKITLDALKTIGIDEEEQDQIFKILA 328
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  367 AIMHFGNMKFKqKPREEQLEADGTENADKAAFLMGINSSELVKCLIHPRIKVGNEYVTRGQTIEQVTCAVGALSKSMYER 446
Cdd:COG5022   329 AILHIGNIEFK-EDRNGAAIFSDNSVLDKACYLLGIDPSLFVKWLVKRQIKTGGEWIVVPLNLEQALAIRDSLAKALYSN 407
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  447 MFKWLVARINRALDAKLSRQFFIGILDITGFEILEYNSLEQLCINFTNEKLQQFFNWHMFVLEQEEYKKESIEWVSIGFg 526
Cdd:COG5022   408 LFDWIVDRINKSLDHSAAASNFIGVLDIYGFEIFEKNSFEQLCINYTNEKLQQFFNQHMFKLEQEEYVKEGIEWSFIDY- 486
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  527 LDLQACIDLIEK--PMGILSILEEECMFPKATDLTFKTKLFDN-HFGKSVHLQKPKPDKKKfeahFELVHYAGVVPYNIS 603
Cdd:COG5022   487 FDNQPCIDLIEKknPLGILSLLDEECVMPHATDESFTSKLAQRlNKNSNPKFKKSRFRDNK----FVVKHYAGDVEYDVE 562
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  604 GWLEKNKDLLNETVVAVFQKSSNRLLASLFENYMSTdsaipfgEKKRKkgasFQTVASLHKENLNKLMTNLKSTAPHFVR 683
Cdd:COG5022   563 GFLDKNKDPLNDDLLELLKASTNEFVSTLFDDEENI-------ESKGR----FPTLGSRFKESLNSLMSTLNSTQPHYIR 631
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  684 CINPNVNKIPGILDPYLVLQQLRCNGVLEGTRICREGFPNRLQYADFKQRYCILNP---RTFPKSKFVSSRKAAEELLGS 760
Cdd:COG5022   632 CIKPNEEKSPWTFDNQMVLSQLRCCGVLETIRISRAGFPSRWTFDEFVQRYRILSPsksWTGEYTWKEDTKNAVKSILEE 711
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  761 LEIDHTQYRFGITKVFFKAGFLGQLEAIRDERLSKVFTLFQARAQGKLMRIKFQKILEERDALILIQWNIRAFMAVKNWP 840
Cdd:COG5022   712 LVIDSSKYQIGNTKVFFKAGVLAALEDMRDAKLDNIATRIQRAIRGRYLRRRYLQALKRIKKIQVIQHGFRLRRLVDYEL 791
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  841 WMRLFFKIKPLVKSSEVGEEVaGLKEECAQlqkaleksEFQREELKAKQVSLTQEKNDLIlqlqaeqetlanveeQCEWL 920
Cdd:COG5022   792 KWRLFIKLQPLLSLLGSRKEY-RSYLACII--------KLQKTIKREKKLRETEEVEFSL---------------KAEVL 847
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  921 IKSKIQLEARVKELSERVEEEEEINSelTARGRKLEDECFELKKEIDDLETM-LVKSEKEKRTTEHK---VKNLTEEVEF 996
Cdd:COG5022   848 IQKFGRSLKAKKRFSLLKKETIYLQS--AQRVELAERQLQELKIDVKSISSLkLVNLELESEIIELKkslSSDLIENLEF 925
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  997 LNEDISKL-----NRAAKVVQEAHQQTLDDLHMEEEKLSSLSKANLKLEQQVDELEGALEQERKARMNCER---ELHKLE 1068
Cdd:COG5022   926 KTELIARLkkllnNIDLEEGPSIEYVKLPELNKLHEVESKLKETSEEYEDLLKKSTILVREGNKANSELKNfkkELAELS 1005
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1069 GNLKLNRESMENLESSQRHLAeELRKKELELSQMNSKVENEKGlvaqLQKTVKELQTQIKDLKEKLEAerttrAKMERER 1148
Cdd:COG5022  1006 KQYGALQESTKQLKELPVEVA-ELQSASKIISSESTELSILKP----LQKLKGLLLLENNQLQARYKA-----LKLRREN 1075
                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1149 adltQDLADLNERLEEVGGSSLAQLEITKKQETKFQKLHRDMEEATLHFETTSASLKKRHADSLAELegqVENLQQVKQK 1228
Cdd:COG5022  1076 ----SLLDDKQLYQLESTENLLKTINVKDLEVTNRNLVKPANVLQFIVAQMIKLNLLQEISKFLSQL---VNTLEPVFQK 1148
                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1229 LEKDksdlQLEVDDLLTrvEQMTRAKANAEKLCTLYEERLHEA-------TAKLDKVTQLANDLAAQKTKLWSES--GEF 1299
Cdd:COG5022  1149 LSVL----QLELDGLFW--EANLEALPSPPPFAALSEKRLYQSalydeksKLSSSEVNDLKNELIALFSKIFSGWprGDK 1222
                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1300 LRRLEEKEALINQLSR--EKSNFTRQIEDLRGQLEKEtksqsALAHALQKAQRDCDLLREQYEEE--------QEVKAEL 1369
Cdd:COG5022  1223 LKKLISEGWVPTEYSTslKGFNNLNKKFDTPASMSNE-----KLLSLLNSIDNLLSSYKLEEEVLpatinsllQYINVGL 1297
                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1370 HRTLSKVNAEMvqwRMKYENNVIQRTEDLEDAKKELAI-RLQEAAEamgvanarnaSLERARHQLQLELGDaLSDLGKVR 1448
Cdd:COG5022  1298 FNALRTKASSL---RWKSATEVNYNSEELDDWCREFEIsDVDEELE----------ELIQAVKVLQLLKDD-LNKLDELL 1363
                        1450
                  ....*....|..
gi 767926067 1449 SAAARLDQKQLQ 1460
Cdd:COG5022  1364 DACYSLNPAEIQ 1375
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
1093-1932 2.35e-29

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 128.25  E-value: 2.35e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1093 RKKELElSQMNSKVENekglVAQLQKTVKELQTQIKDLKEKLE-AERTTRAKMERERADLTQDLADLNERLEEVggssLA 1171
Cdd:TIGR02168  173 RRKETE-RKLERTREN----LDRLEDILNELERQLKSLERQAEkAERYKELKAELRELELALLVLRLEELREEL----EE 243
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1172 QLEITKKQETKFQKLHRDMEEATLHFETTSASLKKRHaDSLAELEGQVENLQQVKQKLEKDKSDLQLEVDDLLTRVEQMT 1251
Cdd:TIGR02168  244 LQEELKEAEEELEELTAELQELEEKLEELRLEVSELE-EEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELE 322
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1252 RAKANAEKLCTLYEERLHEATAKLDKVTQLANDLAAQKTKLWSESGEFLRRLEEKEALINQLSREKSNFTRQIEDLRGQL 1331
Cdd:TIGR02168  323 AQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEI 402
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1332 EKETKSQSALAHALQKAQRDCDLLREQYEEEQevKAELHRTLSKVNAEMVQWRMKYEnNVIQRTEDLEDAKKELAIRLQE 1411
Cdd:TIGR02168  403 ERLEARLERLEDRRERLQQEIEELLKKLEEAE--LKELQAELEELEEELEELQEELE-RLEEALEELREELEEAEQALDA 479
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1412 AAEAMGVANARNASLERARHQLQlelgdalsdlGKVRSAAARLDQKQLQSGkaladwkqkheesqalldasqkeVQALST 1491
Cdd:TIGR02168  480 AERELAQLQARLDSLERLQENLE----------GFSEGVKALLKNQSGLSG-----------------------ILGVLS 526
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1492 ELLKLKNTYEESIvgqETLRREnkNLQEEISNLTNQVREGTKNLTEMEKVKKLIEEEKTEVQVTLEETEGALERNESKIL 1571
Cdd:TIGR02168  527 ELISVDEGYEAAI---EAALGG--RLQAVVVENLNAAKKAIAFLKQNELGRVTFLPLDSIKGTEIQGNDREILKNIEGFL 601
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1572 HFQLELLEAKAELERKLS----------EKDEEIENFRR-KQQCTIDSLQSSL-----------DSEAKSRIEVTRLKKK 1629
Cdd:TIGR02168  602 GVAKDLVKFDPKLRKALSyllggvlvvdDLDNALELAKKlRPGYRIVTLDGDLvrpggvitggsAKTNSSILERRREIEE 681
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1630 MEEDLNEMELQLSCANRQVSEATKSLGQLQIQIKDLQMQLDDSTQLNSDLKEQVAVAERRNSLLQSELEDLRSLQEQTER 1709
Cdd:TIGR02168  682 LEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEA 761
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1710 GRRLSEEELLEATERInlfytqnTSLLSQKKKLEADVARMQKEAEEVVQECQNAEEKAKKAAIEAANLSEELKKKQDTIA 1789
Cdd:TIGR02168  762 EIEELEERLEEAEEEL-------AEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIA 834
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1790 HLERTRENMEQTITDLQKRLAEAE------QMALMGSRKQIQKLESRVRELEGELEGEIRRSAEAQRGARRLERCIKELT 1863
Cdd:TIGR02168  835 ATERRLEDLEEQIEELSEDIESLAaeieelEELIEELESELEALLNERASLEEALALLRSELEELSEELRELESKRSELR 914
                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1864 YQAEEDKKNLSRMQTQMDKLQLKVQNYKQQV-EVAETQANQYLSKYKKQQHELNEVKERAEVAESQVNKL 1932
Cdd:TIGR02168  915 RELEELREKLAQLELRLEGLEVRIDNLQERLsEEYSLTLEEAEALENKIEDDEEEARRRLKRLENKIKEL 984
 
Name Accession Description Interval E-value
MYSc_Myh15_mammals cd14929
class II myosin heavy chain 15, motor domain; Myosin motor domain of sarcomeric myosin heavy ...
117-778 0e+00

class II myosin heavy chain 15, motor domain; Myosin motor domain of sarcomeric myosin heavy chain 15 in mammals (also called KIAA1000) . MYH15 is a slow-twitch myosin. Myh15 is a ventricular myosin heavy chain. Myh15 is absent in embryonic and fetal muscles and is found in orbital layer of extraocular muscles at birth. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276892 [Multi-domain]  Cd Length: 662  Bit Score: 1430.14  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  117 ASVLHTLKRRYGQWMIYTYSGLFCVTINPYKWLPVYQKEVMAAYKGKRRSEAPPHIFAVANNAFQDMLHNRENQSILFTG 196
Cdd:cd14929     1 ASVLHTLRRRYDHWMIYTYSGLFCVTINPYKWLPVYQKEVMAAYKGKRRSEAPPHIFAVANNAFQDMLHNRENQSILFTG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  197 ESGAGKTVNSKHIIQYFATIAAMIESRKKQGALEDQIMQANTILEAFGNAKTLRNDNSSRFGKFIRMHFGARGMLSSVDI 276
Cdd:cd14929    81 ESGAGKTVNTKHIIQYFATIAAMIESKKKLGALEDQIMQANPVLEAFGNAKTLRNDNSSRFGKFIRMHFGARGMLSSADI 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  277 DIYLLEKSRVIFQQAGERNYHIFYQILSGQKELHDLLLVSANPSDFHFCSCGAVTVESLDDAEELLATEQAMDILGFLPD 356
Cdd:cd14929   161 DIYLLEKSRVIFQQPGERNYHIFYQILSGKKELRDLLLVSANPSDFHFCSCGAVAVESLDDAEELLATEQAMDILGFLPD 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  357 EKYGCYKLTGAIMHFGNMKFKQKPREEQLEADGTENADKAAFLMGINSSELVKCLIHPRIKVGNEYVTRGQTIEQVTCAV 436
Cdd:cd14929   241 EKYGCYKLTGAIMHFGNMKFKQKPREEQLEADGTENADKAAFLMGINSSELVKGLIHPRIKVGNEYVTRSQNIEQVTYAV 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  437 GALSKSMYERMFKWLVARINRALDAKLSRQFFIGILDITGFEILEYNSLEQLCINFTNEKLQQFFNWHMFVLEQEEYKKE 516
Cdd:cd14929   321 GALSKSIYERMFKWLVARINRVLDAKLSRQFFIGILDITGFEILDYNSLEQLCINFTNEKLQQFFNQHMFVLEQEEYRKE 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  517 SIEWVSIGFGLDLQACIDLIEKPMGILSILEEECMFPKATDLTFKTKLFDNHFGKSVHLQKPKPDKKKFEAHFELVHYAG 596
Cdd:cd14929   401 GIDWVSIDFGLDLQACIDLIEKPMGIFSILEEECMFPKATDLTFKTKLFDNHFGKSVHFQKPKPDKKKFEAHFELVHYAG 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  597 VVPYNISGWLEKNKDLLNETVVAVFQKSSNRLLASLFENYMSTDSAIPFGEKKRKKGASFQTVASLHKENLNKLMTNLKS 676
Cdd:cd14929   481 VVPYNISGWLEKNKDLLNETVVAVFQKSSNRLLASLFENYISTDSAIQFGEKKRKKGASFQTVASLHKENLNKLMTNLKS 560
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  677 TAPHFVRCINPNVNKIPGILDPYLVLQQLRCNGVLEGTRICREGFPNRLQYADFKQRYCILNPRTFPKSKFVSSRKAAEE 756
Cdd:cd14929   561 TAPHFVRCINPNVNKIPGVLDPYLVLQQLRCNGVLEGIRICREGFPNRLLYADFKQRYCILNPRTFPKSKFVSSRKAAEE 640
                         650       660
                  ....*....|....*....|..
gi 767926067  757 LLGSLEIDHTQYRFGITKVFFK 778
Cdd:cd14929   641 LLGSLEIDHTQYRFGITKVFFK 662
Myosin_head pfam00063
Myosin head (motor domain);
105-778 0e+00

Myosin head (motor domain);


Pssm-ID: 395017 [Multi-domain]  Cd Length: 674  Bit Score: 959.81  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   105 IEDMAMLTHLNEASVLHTLKRRYGQWMIYTYSGLFCVTINPYKWLPVYQKEVMAAYKGKRRSEAPPHIFAVANNAFQDML 184
Cdd:pfam00063    1 VEDMVELSYLNEPSVLHNLKKRYKSDLIYTYSGLVLVAVNPYKQLPIYSEDMIKAYRGKRRGELPPHIFAIADEAYRSML 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   185 HNRENQSILFTGESGAGKTVNSKHIIQYFATIAAmIESRKKQGALEDQIMQANTILEAFGNAKTLRNDNSSRFGKFIRMH 264
Cdd:pfam00063   81 QDKENQSILISGESGAGKTENTKKIMQYLASVSG-SGSAGNVGRLEEQILQSNPILEAFGNAKTVRNNNSSRFGKYIEIQ 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   265 FGARGMLSSVDIDIYLLEKSRVIFQQAGERNYHIFYQILSG--QKELHDLLLvsANPSDFHFCS-CGAVTVESLDDAEEL 341
Cdd:pfam00063  160 FDAKGDIVGGKIETYLLEKSRVVYQAEGERNYHIFYQLLAGasAQLKKELRL--TNPKDYHYLSqSGCYTIDGIDDSEEF 237
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   342 LATEQAMDILGFLPDEKYGCYKLTGAIMHFGNMKFKQKPREEQLEADGTENADKAAFLMGINSSELVKCLIHPRIKVGNE 421
Cdd:pfam00063  238 KITDKAMDILGFSDEEQMGIFRIVAAILHLGNIEFKKERNDEQAVPDDTENLQKAASLLGIDSTELEKALCKRRIKTGRE 317
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   422 YVTRGQTIEQVTCAVGALSKSMYERMFKWLVARINRALDAK-LSRQFFIGILDITGFEILEYNSLEQLCINFTNEKLQQF 500
Cdd:pfam00063  318 TVSKPQNVEQANYARDALAKAIYSRLFDWLVDRINKSLDVKtIEKASFIGVLDIYGFEIFEKNSFEQLCINYVNEKLQQF 397
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   501 FNWHMFVLEQEEYKKESIEWVSIGFGlDLQACIDLIE-KPMGILSILEEECMFPKATDLTFKTKLFDnHFGKSVHLQKPK 579
Cdd:pfam00063  398 FNHHMFKLEQEEYVREGIEWTFIDFG-DNQPCIDLIEkKPLGILSLLDEECLFPKATDQTFLDKLYS-TFSKHPHFQKPR 475
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   580 PdkkKFEAHFELVHYAGVVPYNISGWLEKNKDLLNETVVAVFQKSSNRLLASLFENYMSTDSAIPFGE----KKRKKGAS 655
Cdd:pfam00063  476 L---QGETHFIIKHYAGDVEYNVEGFLEKNKDPLNDDLVSLLKSSSDPLLAELFPDYETAESAAANESgkstPKRTKKKR 552
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   656 FQTVASLHKENLNKLMTNLKSTAPHFVRCINPNVNKIPGILDPYLVLQQLRCNGVLEGTRICREGFPNRLQYADFKQRYC 735
Cdd:pfam00063  553 FITVGSQFKESLGELMKTLNSTNPHYIRCIKPNEKKRAGVFDNSLVLHQLRCNGVLEGIRIRRAGFPNRITFQEFVQRYR 632
                          650       660       670       680
                   ....*....|....*....|....*....|....*....|...
gi 767926067   736 ILNPRTFPKSkFVSSRKAAEELLGSLEIDHTQYRFGITKVFFK 778
Cdd:pfam00063  633 ILAPKTWPKW-KGDAKKGCEAILQSLNLDKEEYQFGKTKIFFR 674
MYSc smart00242
Myosin. Large ATPases; ATPase; molecular motor. Muscle contraction consists of a cyclical ...
98-790 0e+00

Myosin. Large ATPases; ATPase; molecular motor. Muscle contraction consists of a cyclical interaction between myosin and actin. The core of the myosin structure is similar in fold to that of kinesin.


Pssm-ID: 214580 [Multi-domain]  Cd Length: 677  Bit Score: 933.11  E-value: 0e+00
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067     98 NPPEFEMIEDMAMLTHLNEASVLHTLKRRYGQWMIYTYSGLFCVTINPYKWLPVYQKEVMAAYKGKRRSEAPPHIFAVAN 177
Cdd:smart00242    1 NPPKFEGVEDLVLLTYLNEPAVLHNLKKRYLKDLIYTYIGLVLVAVNPYKQLPIYTDEVIKKYRGKSRGELPPHVFAIAD 80
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067    178 NAFQDMLHNRENQSILFTGESGAGKTVNSKHIIQYFATIAAmieSRKKQGALEDQIMQANTILEAFGNAKTLRNDNSSRF 257
Cdd:smart00242   81 NAYRNMLNDKENQSIIISGESGAGKTENTKKIMQYLASVSG---SNTEVGSVEDQILESNPILEAFGNAKTLRNNNSSRF 157
                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067    258 GKFIRMHFGARGMLSSVDIDIYLLEKSRVIFQQAGERNYHIFYQILSG--QKELHDLLLvsANPSDFHFCS-CGAVTVES 334
Cdd:smart00242  158 GKFIEIHFDAKGKIIGAKIETYLLEKSRVVSQAKGERNYHIFYQLLAGasEELKKELGL--KSPEDYRYLNqGGCLTVDG 235
                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067    335 LDDAEELLATEQAMDILGFLPDEKYGCYKLTGAIMHFGNMKFKQKPREEQLEA-DGTENADKAAFLMGINSSELVKCLIH 413
Cdd:smart00242  236 IDDAEEFKETLNAMRVLGFSEEEQESIFKILAAILHLGNIEFEEGRNDNAASTvKDKEELSNAAELLGVDPEELEKALTK 315
                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067    414 PRIKVGNEYVTRGQTIEQVTCAVGALSKSMYERMFKWLVARINRALDAKLSRQFFIGILDITGFEILEYNSLEQLCINFT 493
Cdd:smart00242  316 RKIKTGGEVITKPLNVEQALDARDALAKALYSRLFDWLVKRINQSLSFKDGSTYFIGVLDIYGFEIFEVNSFEQLCINYA 395
                           410       420       430       440       450       460       470       480
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067    494 NEKLQQFFNWHMFVLEQEEYKKESIEWVSIGFGlDLQACIDLIE-KPMGILSILEEECMFPKATDLTFKTKLfDNHFGKS 572
Cdd:smart00242  396 NEKLQQFFNQHVFKLEQEEYEREGIDWTFIDFF-DNQDCIDLIEkKPPGILSLLDEECRFPKGTDQTFLEKL-NQHHKKH 473
                           490       500       510       520       530       540       550       560
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067    573 VHLQKPkpdKKKFEAHFELVHYAGVVPYNISGWLEKNKDLLNETVVAVFQKSSNRLLASLFENYmstdsaipfgEKKRKK 652
Cdd:smart00242  474 PHFSKP---KKKGRTEFIIKHYAGDVTYDVTGFLEKNKDTLSDDLIELLQSSKNPLIASLFPSG----------VSNAGS 540
                           570       580       590       600       610       620       630       640
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067    653 GASFQTVASLHKENLNKLMTNLKSTAPHFVRCINPNVNKIPGILDPYLVLQQLRCNGVLEGTRICREGFPNRLQYADFKQ 732
Cdd:smart00242  541 KKRFQTVGSQFKEQLNELMDTLNSTNPHFIRCIKPNEEKKPGDFDSSLVLHQLRYLGVLENIRIRRAGFPYRLPFDEFLQ 620
                           650       660       670       680       690
                    ....*....|....*....|....*....|....*....|....*....|....*...
gi 767926067    733 RYCILNPRTFPkSKFVSSRKAAEELLGSLEIDHTQYRFGITKVFFKAGFLGQLEAIRD 790
Cdd:smart00242  621 RYRVLLPDTWP-PWGGDAKKACEALLQSLGLDEDEYQLGKTKVFLRPGQLAELEELRE 677
COG5022 COG5022
Myosin heavy chain [General function prediction only];
53-1460 0e+00

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 817.39  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   53 KCWIPDGENAYIEAEVKGSEDDGTVIVETAD---GESLSIKEDKIQQ--MNPPEFEMIEDMAMLTHLNEASVLHTLKRRY 127
Cdd:COG5022    11 GCWIPDEEKGWIWAEIIKEAFNKGKVTEEGKkedGESVSVKKKVLGNdrIKLPKFDGVDDLTELSYLNEPAVLHNLEKRY 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  128 GQWMIYTYSGLFCVTINPYKWLPVYQKEVMAAYKGKRRSEAPPHIFAVANNAFQDMLHNRENQSILFTGESGAGKTVNSK 207
Cdd:COG5022    91 NNGQIYTYSGLVLIAVNPYRDLGIYTDDIIQSYSGKNRLELEPHVFAIAEEAYRNLLSEKENQTIIISGESGAGKTENAK 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  208 HIIQYFATIAAMIESRKKQgaLEDQIMQANTILEAFGNAKTLRNDNSSRFGKFIRMHFGARGMLSSVDIDIYLLEKSRVI 287
Cdd:COG5022   171 RIMQYLASVTSSSTVEISS--IEKQILATNPILEAFGNAKTVRNDNSSRFGKYIKIEFDENGEICGAKIETYLLEKSRVV 248
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  288 FQQAGERNYHIFYQILSGQKELHDLLLVSANPSDFHFCSCGAVT-VESLDDAEELLATEQAMDILGFLPDEKYGCYKLTG 366
Cdd:COG5022   249 HQNKNERNYHIFYQLLAGDPEELKKLLLLQNPKDYIYLSQGGCDkIDGIDDAKEFKITLDALKTIGIDEEEQDQIFKILA 328
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  367 AIMHFGNMKFKqKPREEQLEADGTENADKAAFLMGINSSELVKCLIHPRIKVGNEYVTRGQTIEQVTCAVGALSKSMYER 446
Cdd:COG5022   329 AILHIGNIEFK-EDRNGAAIFSDNSVLDKACYLLGIDPSLFVKWLVKRQIKTGGEWIVVPLNLEQALAIRDSLAKALYSN 407
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  447 MFKWLVARINRALDAKLSRQFFIGILDITGFEILEYNSLEQLCINFTNEKLQQFFNWHMFVLEQEEYKKESIEWVSIGFg 526
Cdd:COG5022   408 LFDWIVDRINKSLDHSAAASNFIGVLDIYGFEIFEKNSFEQLCINYTNEKLQQFFNQHMFKLEQEEYVKEGIEWSFIDY- 486
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  527 LDLQACIDLIEK--PMGILSILEEECMFPKATDLTFKTKLFDN-HFGKSVHLQKPKPDKKKfeahFELVHYAGVVPYNIS 603
Cdd:COG5022   487 FDNQPCIDLIEKknPLGILSLLDEECVMPHATDESFTSKLAQRlNKNSNPKFKKSRFRDNK----FVVKHYAGDVEYDVE 562
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  604 GWLEKNKDLLNETVVAVFQKSSNRLLASLFENYMSTdsaipfgEKKRKkgasFQTVASLHKENLNKLMTNLKSTAPHFVR 683
Cdd:COG5022   563 GFLDKNKDPLNDDLLELLKASTNEFVSTLFDDEENI-------ESKGR----FPTLGSRFKESLNSLMSTLNSTQPHYIR 631
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  684 CINPNVNKIPGILDPYLVLQQLRCNGVLEGTRICREGFPNRLQYADFKQRYCILNP---RTFPKSKFVSSRKAAEELLGS 760
Cdd:COG5022   632 CIKPNEEKSPWTFDNQMVLSQLRCCGVLETIRISRAGFPSRWTFDEFVQRYRILSPsksWTGEYTWKEDTKNAVKSILEE 711
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  761 LEIDHTQYRFGITKVFFKAGFLGQLEAIRDERLSKVFTLFQARAQGKLMRIKFQKILEERDALILIQWNIRAFMAVKNWP 840
Cdd:COG5022   712 LVIDSSKYQIGNTKVFFKAGVLAALEDMRDAKLDNIATRIQRAIRGRYLRRRYLQALKRIKKIQVIQHGFRLRRLVDYEL 791
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  841 WMRLFFKIKPLVKSSEVGEEVaGLKEECAQlqkaleksEFQREELKAKQVSLTQEKNDLIlqlqaeqetlanveeQCEWL 920
Cdd:COG5022   792 KWRLFIKLQPLLSLLGSRKEY-RSYLACII--------KLQKTIKREKKLRETEEVEFSL---------------KAEVL 847
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  921 IKSKIQLEARVKELSERVEEEEEINSelTARGRKLEDECFELKKEIDDLETM-LVKSEKEKRTTEHK---VKNLTEEVEF 996
Cdd:COG5022   848 IQKFGRSLKAKKRFSLLKKETIYLQS--AQRVELAERQLQELKIDVKSISSLkLVNLELESEIIELKkslSSDLIENLEF 925
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  997 LNEDISKL-----NRAAKVVQEAHQQTLDDLHMEEEKLSSLSKANLKLEQQVDELEGALEQERKARMNCER---ELHKLE 1068
Cdd:COG5022   926 KTELIARLkkllnNIDLEEGPSIEYVKLPELNKLHEVESKLKETSEEYEDLLKKSTILVREGNKANSELKNfkkELAELS 1005
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1069 GNLKLNRESMENLESSQRHLAeELRKKELELSQMNSKVENEKGlvaqLQKTVKELQTQIKDLKEKLEAerttrAKMERER 1148
Cdd:COG5022  1006 KQYGALQESTKQLKELPVEVA-ELQSASKIISSESTELSILKP----LQKLKGLLLLENNQLQARYKA-----LKLRREN 1075
                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1149 adltQDLADLNERLEEVGGSSLAQLEITKKQETKFQKLHRDMEEATLHFETTSASLKKRHADSLAELegqVENLQQVKQK 1228
Cdd:COG5022  1076 ----SLLDDKQLYQLESTENLLKTINVKDLEVTNRNLVKPANVLQFIVAQMIKLNLLQEISKFLSQL---VNTLEPVFQK 1148
                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1229 LEKDksdlQLEVDDLLTrvEQMTRAKANAEKLCTLYEERLHEA-------TAKLDKVTQLANDLAAQKTKLWSES--GEF 1299
Cdd:COG5022  1149 LSVL----QLELDGLFW--EANLEALPSPPPFAALSEKRLYQSalydeksKLSSSEVNDLKNELIALFSKIFSGWprGDK 1222
                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1300 LRRLEEKEALINQLSR--EKSNFTRQIEDLRGQLEKEtksqsALAHALQKAQRDCDLLREQYEEE--------QEVKAEL 1369
Cdd:COG5022  1223 LKKLISEGWVPTEYSTslKGFNNLNKKFDTPASMSNE-----KLLSLLNSIDNLLSSYKLEEEVLpatinsllQYINVGL 1297
                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1370 HRTLSKVNAEMvqwRMKYENNVIQRTEDLEDAKKELAI-RLQEAAEamgvanarnaSLERARHQLQLELGDaLSDLGKVR 1448
Cdd:COG5022  1298 FNALRTKASSL---RWKSATEVNYNSEELDDWCREFEIsDVDEELE----------ELIQAVKVLQLLKDD-LNKLDELL 1363
                        1450
                  ....*....|..
gi 767926067 1449 SAAARLDQKQLQ 1460
Cdd:COG5022  1364 DACYSLNPAEIQ 1375
PTZ00014 PTZ00014
myosin-A; Provisional
79-838 1.11e-128

myosin-A; Provisional


Pssm-ID: 240229 [Multi-domain]  Cd Length: 821  Bit Score: 425.21  E-value: 1.11e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   79 VETADGESLSIKEDKIQQMNPP-EFEMIEDMAMLTHLNEASVLHTLKRRYGQWMIYTYSGLFCVTINPYKWLPVYQKEVM 157
Cdd:PTZ00014   71 IDPPTNSTFEVKPEHAFNANSQiDPMTYGDIGLLPHTNIPCVLDFLKHRYLKNQIYTTADPLLVAINPFKDLGNTTNDWI 150
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  158 AAYKGKRRSEA-PPHIFAVANNAFQDMLHNRENQSILFTGESGAGKTVNSKHIIQYFATIAAMIESRKKQGAledqIMQA 236
Cdd:PTZ00014  151 RRYRDAKDSDKlPPHVFTTARRALENLHGVKKSQTIIVSGESGAGKTEATKQIMRYFASSKSGNMDLKIQNA----IMAA 226
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  237 NTILEAFGNAKTLRNDNSSRFGKFIRMHFGARGMLSSVDIDIYLLEKSRVIFQQAGERNYHIFYQILSG-----QKELHD 311
Cdd:PTZ00014  227 NPVLEAFGNAKTIRNNNSSRFGRFMQLQLGEEGGIRYGSIVAFLLEKSRVVTQEDDERSYHIFYQLLKGandemKEKYKL 306
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  312 LLLvsanpSDFHFCSCGAVTVESLDDAEELLATEQAMDILGFLPDEKYGCYKLTGAIMHFGNMKFKQKPREEQLEADGTE 391
Cdd:PTZ00014  307 KSL-----EEYKYINPKCLDVPGIDDVKDFEEVMESFDSMGLSESQIEDIFSILSGVLLLGNVEIEGKEEGGLTDAAAIS 381
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  392 NADKAAF-----LMGINSSELVKCLIHPRIKVGNEYVTRGQTIEQVTCAVGALSKSMYERMFKWLVARINRALDAKLSRQ 466
Cdd:PTZ00014  382 DESLEVFneaceLLFLDYESLKKELTVKVTYAGNQKIEGPWSKDESEMLKDSLSKAVYEKLFLWIIRNLNATIEPPGGFK 461
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  467 FFIGILDITGFEILEYNSLEQLCINFTNEKLQQFFNWHMFVLEQEEYKKESIEWVSIGFGLDLQACIDLIEKPMGILSIL 546
Cdd:PTZ00014  462 VFIGMLDIFGFEVFKNNSLEQLFINITNEMLQKNFVDIVFERESKLYKDEGISTEELEYTSNESVIDLLCGKGKSVLSIL 541
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  547 EEECMFPKATDLTFkTKLFDNHFGKSVHLQKPKPDKKKfeaHFELVHYAGVVPYNISGWLEKNKDLLNETVVAVFQKSSN 626
Cdd:PTZ00014  542 EDQCLAPGGTDEKF-VSSCNTNLKNNPKYKPAKVDSNK---NFVIKHTIGDIQYCASGFLFKNKDVLRPELVEVVKASPN 617
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  627 RLLASLFENYMSTDSAIpfgekkrKKGasfQTVASLHKENLNKLMTNLKSTAPHFVRCINPNVNKIPGILDPYLVLQQLR 706
Cdd:PTZ00014  618 PLVRDLFEGVEVEKGKL-------AKG---QLIGSQFLNQLDSLMSLINSTEPHFIRCIKPNENKKPLDWNSSKVLIQLH 687
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  707 CNGVLEGTRICREGFPNRLQYADFKQRYCILNPRTFPKSKfVSSRKAAEELLGSLEIDHTQYRFGITKVFFKAGFLGQLE 786
Cdd:PTZ00014  688 SLSILEALQLRQLGFSYRRTFAEFLSQFKYLDLAVSNDSS-LDPKEKAEKLLERSGLPKDSYAIGKTMVFLKKDAAKELT 766
                         730       740       750       760       770
                  ....*....|....*....|....*....|....*....|....*....|...
gi 767926067  787 AIRDERLSKVFTLFQArAQGKLMRIKFQKILEER-DALILIQWNIRAFMAVKN 838
Cdd:PTZ00014  767 QIQREKLAAWEPLVSV-LEALILKIKKKRKVRKNiKSLVRIQAHLRRHLVIAE 818
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
859-1935 4.60e-116

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 396.47  E-value: 4.60e-116
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   859 EEVAGLKEEcaQLQKALE---KSEFQREELKAKQVSLTQEKNDLILQLQAEQETLANVEEQCEWLIKSKIQLEARVKELS 935
Cdd:pfam01576    4 EEEMQAKEE--ELQKVKErqqKAESELKELEKKHQQLCEEKNALQEQLQAETELCAEAEEMRARLAARKQELEEILHELE 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   936 ERVEEEEEINSELTARGRKLEDECFELKKEIDDLETMLVKSEKEKRTTEHKVKNLTEEVEFLNEDISKLNRAAKVVQEAH 1015
Cdd:pfam01576   82 SRLEEEEERSQQLQNEKKKMQQHIQDLEEQLDEEEAARQKLQLEKVTTEAKIKKLEEDILLLEDQNSKLSKERKLLEERI 161
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1016 QQTLDDLHMEEEKLSSLSKANLKLEQQVDELEGALEQERKARMNCERELHKLEGNLKLNRESMENLESSQRHLAEELRKK 1095
Cdd:pfam01576  162 SEFTSNLAEEEEKAKSLSKLKNKHEAMISDLEERLKKEEKGRQELEKAKRKLEGESTDLQEQIAELQAQIAELRAQLAKK 241
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1096 ELELSQMNSKVENEKGLVAQLQKTVKELQTQIKDLKEKLEAERTTRAKMERERADLTQDLADLNERLEEVGGSSLAQLEI 1175
Cdd:pfam01576  242 EEELQAALARLEEETAQKNNALKKIRELEAQISELQEDLESERAARNKAEKQRRDLGEELEALKTELEDTLDTTAAQQEL 321
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1176 TKKQETKFQKLHRDMEEATLHFETTSASLKKRHADSLAELEGQVENLQQVKQKLEKDKSDLQLEVDDLLTRVEQMTRAKA 1255
Cdd:pfam01576  322 RSKREQEVTELKKALEEETRSHEAQLQEMRQKHTQALEELTEQLEQAKRNKANLEKAKQALESENAELQAELRTLQQAKQ 401
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1256 NAEKLCTLYEERLHEATAKLDKVTQLANDLAAQKTKLWSESGEFLRRLEEKEALINQLSREKSNFTRQIEDLRGQLEKET 1335
Cdd:pfam01576  402 DSEHKRKKLEGQLQELQARLSESERQRAELAEKLSKLQSELESVSSLLNEAEGKNIKLSKDVSSLESQLQDTQELLQEET 481
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1336 KSQSALAHALQKAQRDCDLLREQYEEEQEVKAELHRTLSKVNAEMVQWRMKYEnNVIQRTEDLEDAKKELAIRLQEAAEA 1415
Cdd:pfam01576  482 RQKLNLSTRLRQLEDERNSLQEQLEEEEEAKRNVERQLSTLQAQLSDMKKKLE-EDAGTLEALEEGKKRLQRELEALTQQ 560
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1416 MGVANARNASLERARHQLQLELGDALSDLGKVRSAAARLDQKQLQSGKALADWKQ-----KHEESQALLDASQKEVQALS 1490
Cdd:pfam01576  561 LEEKAAAYDKLEKTKNRLQQELDDLLVDLDHQRQLVSNLEKKQKKFDQMLAEEKAisaryAEERDRAEAEAREKETRALS 640
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1491 tellkLKNTYEESIVGQETLRRENKNLQEEISNLTNQVREGTKNLTEMEKVKKLIEEEKTEVQVTLEETEGALERNESKI 1570
Cdd:pfam01576  641 -----LARALEEALEAKEELERTNKQLRAEMEDLVSSKDDVGKNVHELERSKRALEQQVEEMKTQLEELEDELQATEDAK 715
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1571 LHFQLELLEAKAELERKLSEKDEEIENFRRKQQCTIDSLQSSLDSEAKSRIEVTRLKKKMEEDLNEMELQLSCANRQVSE 1650
Cdd:pfam01576  716 LRLEVNMQALKAQFERDLQARDEQGEEKRRQLVKQVRELEAELEDERKQRAQAVAAKKKLELDLKELEAQIDAANKGREE 795
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1651 ATKSLGQLQIQIKDLQMQLDDSTQLNSDLKEQVAVAERRNSLLQSELEDLRSLQEQTERGRRLSEEELLEATERINLFYT 1730
Cdd:pfam01576  796 AVKQLKKLQAQMKDLQRELEEARASRDEILAQSKESEKKLKNLEAELLQLQEDLAASERARRQAQQERDELADEIASGAS 875
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1731 QNTSLLSQKKKLEADVARMQKEAEEVVQECQNAEEKAKKAAIEAANLSEELKKKQDTIAHLERTRENMEQTITDLQKRLA 1810
Cdd:pfam01576  876 GKSALQDEKRRLEARIAQLEEELEEEQSNTELLNDRLRKSTLQVEQLTTELAAERSTSQKSESARQQLERQNKELKAKLQ 955
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1811 EAEQMALMGSRKQIQKLESRVRELEGELEGEIRRSAEAQRGARRLERCIKELTYQAEEDKKNLSRMQTQMDKLQLKVQNY 1890
Cdd:pfam01576  956 EMEGTVKSKFKSSIAALEAKIAQLEEQLEQESRERQAANKLVRRTEKKLKEVLLQVEDERRHADQYKDQAEKGNSRMKQL 1035
                         1050      1060      1070      1080
                   ....*....|....*....|....*....|....*....|....*
gi 767926067  1891 KQQVEVAETQANQYLSKYKKQQHELNEVKERAEVAESQVNKLKIK 1935
Cdd:pfam01576 1036 KRQLEEAEEEASRANAARRKLQRELDDATESNESMNREVSTLKSK 1080
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
869-1759 4.24e-30

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 130.56  E-value: 4.24e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   869 AQLQKAlEKSEFQREELKAKQVSL-TQEKNDLILQLQAEQETLANVEEQCEwlikskiQLEARVKELSERVEEEEEINSE 947
Cdd:TIGR02168  207 RQAEKA-ERYKELKAELRELELALlVLRLEELREELEELQEELKEAEEELE-------ELTAELQELEEKLEELRLEVSE 278
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   948 LTARGRKLEDECFELKKEIDDLETMLVKSEKEKRTTEHKVKNLTEEVEFLNEDISKLNRAAKVVQEAHQQTLDDLHMEEE 1027
Cdd:TIGR02168  279 LEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEA 358
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1028 KLSSLSKANLKLEQQVDELEGALEQERKARMNCERELHKLEGNLKLNRESMENLESSQRHLAEELRKKELELsqmnskve 1107
Cdd:TIGR02168  359 ELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKL-------- 430
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1108 nEKGLVAQLQKTVKELQTQIKDLKEKLEAERTTRAKMERERADLTQDLADLNERLEEVGgsslAQLEITKKQETKFQKLH 1187
Cdd:TIGR02168  431 -EEAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQ----ARLDSLERLQENLEGFS 505
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1188 RDMEEATLhfettsaslkkrHADSLAELEGQVENLQQVKQKLEKDKS-DLQLEVDDLLtrVEQMTRAKANAEKLctlyee 1266
Cdd:TIGR02168  506 EGVKALLK------------NQSGLSGILGVLSELISVDEGYEAAIEaALGGRLQAVV--VENLNAAKKAIAFL------ 565
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1267 rlheATAKLDKVTQLANDLAAQkTKLWSESGEFLRRLEEKEALINQLSREKSNFTRQIEDLRGQLeketksqsALAHALQ 1346
Cdd:TIGR02168  566 ----KQNELGRVTFLPLDSIKG-TEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSYLLGGV--------LVVDDLD 632
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1347 KAQRdcdLLREQYEEEQEVKAELHRTL---------SKVNAEMVQWRMKYENNViQRTEDLEDAKKELAIRLQEAAEAMG 1417
Cdd:TIGR02168  633 NALE---LAKKLRPGYRIVTLDGDLVRpggvitggsAKTNSSILERRREIEELE-EKIEELEEKIAELEKALAELRKELE 708
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1418 VANARNASLERARHQLQLELGDALSDLGKVRSAAARLDQKQLQSGKALADWKQKHEESQALLDASQKEVQALSTELLKLK 1497
Cdd:TIGR02168  709 ELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELE 788
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1498 NTYEESIVGQETLRRENKNLQEEISNLTNQVREGTKNLTEMEKVKKLIEEEKTEVQVTLEETEGALERNESKILHFQLEL 1577
Cdd:TIGR02168  789 AQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELI 868
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1578 LEAKAELERKLSEKDEEIENfrrkqqctIDSLQSSLDSEAKSRIEVTRLKKKMEEDLNEMELQLSCANRQVSEATKSLGQ 1657
Cdd:TIGR02168  869 EELESELEALLNERASLEEA--------LALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDN 940
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1658 LQIQIKDL-QMQLDDSTQLNSDLKEQVAVAERRNSLLQSELEDLRSLQEqtergrrLSEEELLEATERINLFYTQNTSLL 1736
Cdd:TIGR02168  941 LQERLSEEySLTLEEAEALENKIEDDEEEARRRLKRLENKIKELGPVNL-------AAIEEYEELKERYDFLTAQKEDLT 1013
                          890       900
                   ....*....|....*....|...
gi 767926067  1737 SQKKKLEADVARMQKEAEEVVQE 1759
Cdd:TIGR02168 1014 EAKETLEEAIEEIDREARERFKD 1036
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
1093-1932 2.35e-29

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 128.25  E-value: 2.35e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1093 RKKELElSQMNSKVENekglVAQLQKTVKELQTQIKDLKEKLE-AERTTRAKMERERADLTQDLADLNERLEEVggssLA 1171
Cdd:TIGR02168  173 RRKETE-RKLERTREN----LDRLEDILNELERQLKSLERQAEkAERYKELKAELRELELALLVLRLEELREEL----EE 243
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1172 QLEITKKQETKFQKLHRDMEEATLHFETTSASLKKRHaDSLAELEGQVENLQQVKQKLEKDKSDLQLEVDDLLTRVEQMT 1251
Cdd:TIGR02168  244 LQEELKEAEEELEELTAELQELEEKLEELRLEVSELE-EEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELE 322
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1252 RAKANAEKLCTLYEERLHEATAKLDKVTQLANDLAAQKTKLWSESGEFLRRLEEKEALINQLSREKSNFTRQIEDLRGQL 1331
Cdd:TIGR02168  323 AQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEI 402
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1332 EKETKSQSALAHALQKAQRDCDLLREQYEEEQevKAELHRTLSKVNAEMVQWRMKYEnNVIQRTEDLEDAKKELAIRLQE 1411
Cdd:TIGR02168  403 ERLEARLERLEDRRERLQQEIEELLKKLEEAE--LKELQAELEELEEELEELQEELE-RLEEALEELREELEEAEQALDA 479
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1412 AAEAMGVANARNASLERARHQLQlelgdalsdlGKVRSAAARLDQKQLQSGkaladwkqkheesqalldasqkeVQALST 1491
Cdd:TIGR02168  480 AERELAQLQARLDSLERLQENLE----------GFSEGVKALLKNQSGLSG-----------------------ILGVLS 526
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1492 ELLKLKNTYEESIvgqETLRREnkNLQEEISNLTNQVREGTKNLTEMEKVKKLIEEEKTEVQVTLEETEGALERNESKIL 1571
Cdd:TIGR02168  527 ELISVDEGYEAAI---EAALGG--RLQAVVVENLNAAKKAIAFLKQNELGRVTFLPLDSIKGTEIQGNDREILKNIEGFL 601
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1572 HFQLELLEAKAELERKLS----------EKDEEIENFRR-KQQCTIDSLQSSL-----------DSEAKSRIEVTRLKKK 1629
Cdd:TIGR02168  602 GVAKDLVKFDPKLRKALSyllggvlvvdDLDNALELAKKlRPGYRIVTLDGDLvrpggvitggsAKTNSSILERRREIEE 681
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1630 MEEDLNEMELQLSCANRQVSEATKSLGQLQIQIKDLQMQLDDSTQLNSDLKEQVAVAERRNSLLQSELEDLRSLQEQTER 1709
Cdd:TIGR02168  682 LEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEA 761
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1710 GRRLSEEELLEATERInlfytqnTSLLSQKKKLEADVARMQKEAEEVVQECQNAEEKAKKAAIEAANLSEELKKKQDTIA 1789
Cdd:TIGR02168  762 EIEELEERLEEAEEEL-------AEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIA 834
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1790 HLERTRENMEQTITDLQKRLAEAE------QMALMGSRKQIQKLESRVRELEGELEGEIRRSAEAQRGARRLERCIKELT 1863
Cdd:TIGR02168  835 ATERRLEDLEEQIEELSEDIESLAaeieelEELIEELESELEALLNERASLEEALALLRSELEELSEELRELESKRSELR 914
                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1864 YQAEEDKKNLSRMQTQMDKLQLKVQNYKQQV-EVAETQANQYLSKYKKQQHELNEVKERAEVAESQVNKL 1932
Cdd:TIGR02168  915 RELEELREKLAQLELRLEGLEVRIDNLQERLsEEYSLTLEEAEALENKIEDDEEEARRRLKRLENKIKEL 984
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
1207-1832 1.03e-17

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 90.00  E-value: 1.03e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1207 RHADSLAELEGQVENLQ-QVKQ-------KLEKDKSDLQL---EVDDLLTRVEQMTRAKANAEKLCTLYEERLHEATAKL 1275
Cdd:COG1196   190 RLEDILGELERQLEPLErQAEKaeryrelKEELKELEAELlllKLRELEAELEELEAELEELEAELEELEAELAELEAEL 269
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1276 DKVTQLANDLAAQKTKLWSESGEFLRRLEEKEALINQLSREKSNFTRQIEDLRGQLEKETKSQSALAHALQKAQRDCDLL 1355
Cdd:COG1196   270 EELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEA 349
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1356 REQYEEEQEVKAELHRTLSKVNAEMVQWrmkyennviqrtedlEDAKKELAIRLQEAAEAMGVANARNASLERARHQLQL 1435
Cdd:COG1196   350 EEELEEAEAELAEAEEALLEAEAELAEA---------------EEELEELAEELLEALRAAAELAAQLEELEEAEEALLE 414
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1436 ELGDALSDLGKVRSAAARLDQKQLQSGKALADWKQKHEESQALLDASQKEVQALSTELLKLKNTYEEsIVGQETLRRENK 1515
Cdd:COG1196   415 RLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAE-LLEELAEAAARL 493
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1516 NLQEEISNLTNQVREGTKNLTEMEKVKKLIEEEKTEVQVTLEETEGALERNESKILHFQLELLEAKAELERKLSEKDEEI 1595
Cdd:COG1196   494 LLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEYLKAAKAGR 573
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1596 ENFrrkqqctidslqssldsEAKSRIEVTRLKKKMEEDLNEMELQLSCANRQVSEAtkslGQLQIQIKDLQMQLDDSTQL 1675
Cdd:COG1196   574 ATF-----------------LPLDKIRARAALAAALARGAIGAAVDLVASDLREAD----ARYYVLGDTLLGRTLVAARL 632
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1676 NSDLKEQVAVAERRNSLLQsELEDLRSLQEQTERGRRLSEEELLEATERInlfytqntsllSQKKKLEADVARMQKEAEE 1755
Cdd:COG1196   633 EAALRRAVTLAGRLREVTL-EGEGGSAGGSLTGGSRRELLAALLEAEAEL-----------EELAERLAEEELELEEALL 700
                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767926067 1756 VVQECQNAEEKAKKAAIEAANLSEELKKKQDTIAHLERTRENMEQTITDLQKRLAEAEQMALMGSRKQIQKLESRVR 1832
Cdd:COG1196   701 AEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELERLEREIE 777
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
1473-1946 2.44e-15

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 82.53  E-value: 2.44e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1473 EESQALLDASQKEVQALSTELLKLKNTYEESIVGqetLRRENKNLQEEISNLTNQV--REGTKNLTEMEKVKKLIEEEKT 1550
Cdd:pfam01576   60 EEMRARLAARKQELEEILHELESRLEEEEERSQQ---LQNEKKKMQQHIQDLEEQLdeEEAARQKLQLEKVTTEAKIKKL 136
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1551 EVQVTLEETEGALERNESKILHfqlellEAKAELERKLSEKDEEIENF---RRKQQCTIDSLQSSLDSEAKSRIEVTRLK 1627
Cdd:pfam01576  137 EEDILLLEDQNSKLSKERKLLE------ERISEFTSNLAEEEEKAKSLsklKNKHEAMISDLEERLKKEEKGRQELEKAK 210
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1628 KKMEEDLNEMELQLSCANRQVSEATKSLGQLQIQIKDLQMQLDDSTQLNSDLKEQVAVAERRNSLLQSELEDLRSLQEQT 1707
Cdd:pfam01576  211 RKLEGESTDLQEQIAELQAQIAELRAQLAKKEEELQAALARLEEETAQKNNALKKIRELEAQISELQEDLESERAARNKA 290
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1708 ERGRRLSEEELlEATeRINLFYTQNTSLLSQ--KKKLEADVARMQK--EAEEVVQECQnAEEKAKKAAIEAANLSEELKK 1783
Cdd:pfam01576  291 EKQRRDLGEEL-EAL-KTELEDTLDTTAAQQelRSKREQEVTELKKalEEETRSHEAQ-LQEMRQKHTQALEELTEQLEQ 367
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1784 KQDTIAHLERTRENMEQTITDLQKRLAEAEQMALMGSRKQiQKLESRVRELEGELEGEIRRSAEAQRGARRLERCIKELT 1863
Cdd:pfam01576  368 AKRNKANLEKAKQALESENAELQAELRTLQQAKQDSEHKR-KKLEGQLQELQARLSESERQRAELAEKLSKLQSELESVS 446
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1864 YQAEEDKKNLSRMQTQMDKLQLKVQNYKQQVEvAETQANQYLSKYKKQ--------QHELNEVKERAEVAESQVNKLKIK 1935
Cdd:pfam01576  447 SLLNEAEGKNIKLSKDVSSLESQLQDTQELLQ-EETRQKLNLSTRLRQledernslQEQLEEEEEAKRNVERQLSTLQAQ 525
                          490
                   ....*....|.
gi 767926067  1936 AREFGKKVQEE 1946
Cdd:pfam01576  526 LSDMKKKLEED 536
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
957-1456 2.54e-14

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 78.93  E-value: 2.54e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  957 DECFELKKEIDDLETMLVKSEKEKRTTEHKVKNLTEEVEFLNEDISKLnraakvvqeahqqtLDDLHMEEEKLSSLskan 1036
Cdd:PRK02224  251 EELETLEAEIEDLRETIAETEREREELAEEVRDLRERLEELEEERDDL--------------LAEAGLDDADAEAV---- 312
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1037 lklEQQVDELEGALEQERKARMNCERELHKLEGNLKLNRESMENLESSqrhlAEELRKKELELsqmNSKVENEKGLVAQL 1116
Cdd:PRK02224  313 ---EARREELEDRDEELRDRLEECRVAAQAHNEEAESLREDADDLEER----AEELREEAAEL---ESELEEAREAVEDR 382
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1117 QKTVKELQTQIKDLKEKLEAERTTRAKMERERADLTQDLADLNERLEEVggsslaqleitkkqETKFQKLHRDMEEATLH 1196
Cdd:PRK02224  383 REEIEELEEEIEELRERFGDAPVDLGNAEDFLEELREERDELREREAEL--------------EATLRTARERVEEAEAL 448
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1197 FE-----TTSASLKKR-HADSLAELEGQVEnlqqvkqKLEKDKSDLQLEVDDLLTRVEQMTRAKANAEKLCTLYE----- 1265
Cdd:PRK02224  449 LEagkcpECGQPVEGSpHVETIEEDRERVE-------ELEAELEDLEEEVEEVEERLERAEDLVEAEDRIERLEErredl 521
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1266 -ERLHEATAKLDKVTQLANDLAAQKTKLWSESGEFLRRLEEKEALINQLSREKSNFTRQIEDL---RGQLEKETKSQSAL 1341
Cdd:PRK02224  522 eELIAERRETIEEKRERAEELRERAAELEAEAEEKREAAAEAEEEAEEAREEVAELNSKLAELkerIESLERIRTLLAAI 601
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1342 AHALQKAQRdcdlLREQYEEEQEVKAELHRTLSKVNAEMVQWRMKYENNviqRTEDLEDAKKELAIRLQEAAEAMgvana 1421
Cdd:PRK02224  602 ADAEDEIER----LREKREALAELNDERRERLAEKRERKRELEAEFDEA---RIEEAREDKERAEEYLEQVEEKL----- 669
                         490       500       510
                  ....*....|....*....|....*....|....*
gi 767926067 1422 rnASLERARHQLQLELGDALSDLGKVRSAAARLDQ 1456
Cdd:PRK02224  670 --DELREERDDLQAEIGAVENELEELEELRERREA 702
PTZ00121 PTZ00121
MAEBL; Provisional
1216-1945 1.46e-13

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 76.72  E-value: 1.46e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1216 EGQVENLQQVKQKLEKDKSDLQLEVDDLLTRVEQMT--RAKANAEKLCTLYEERLHEATAKLDKVTQLANDLAAQKTKlw 1293
Cdd:PTZ00121 1057 EGKAEAKAHVGQDEGLKPSYKDFDFDAKEDNRADEAteEAFGKAEEAKKTETGKAEEARKAEEAKKKAEDARKAEEAR-- 1134
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1294 seSGEFLRRLEEKEALINQlsrEKSNFTRQIEDLRGQLEKETKSQSALAHALQKAQ--RDCDLLREQYEE---EQEVKAE 1368
Cdd:PTZ00121 1135 --KAEDARKAEEARKAEDA---KRVEIARKAEDARKAEEARKAEDAKKAEAARKAEevRKAEELRKAEDArkaEAARKAE 1209
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1369 LHRTLSKVNAEMVQWRMKYENNVIQRTEDLEDAKKELAIRLQEaaEAMGVANARNASLERARHQLQLELGDALSDLGKVR 1448
Cdd:PTZ00121 1210 EERKAEEARKAEDAKKAEAVKKAEEAKKDAEEAKKAEEERNNE--EIRKFEEARMAHFARRQAAIKAEEARKADELKKAE 1287
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1449 SAAARLDQKQLQSGKALADWKQKHEESQALlDASQKEVQALSTELLKLKNTYEESIVGQETLRRENKNLQEEISNlTNQV 1528
Cdd:PTZ00121 1288 EKKKADEAKKAEEKKKADEAKKKAEEAKKA-DEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEA-AEEK 1365
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1529 REGTKNLTEMEKVKKLIEEEKTEVQVTLEETEGALERNESKIlhfqlELLEAKAELERKLSEKDEEIENFRRKQQCTIDS 1608
Cdd:PTZ00121 1366 AEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKA-----DELKKAAAAKKKADEAKKKAEEKKKADEAKKKA 1440
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1609 LQSSLDSEAKSRIEVTR----LKKKMEEDLNEMELQLSCAN-RQVSEATKSLGQLQIQIKDLQMQLDDSTQLNSDLK--E 1681
Cdd:PTZ00121 1441 EEAKKADEAKKKAEEAKkaeeAKKKAEEAKKADEAKKKAEEaKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKaeE 1520
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1682 QVAVAERRNSLLQSELEDLRSLQEQTERGRRLSEEELLEATERinlfytqntSLLSQKKKLEADVARMQKEAEEVVQ-EC 1760
Cdd:PTZ00121 1521 AKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEK---------KKAEEAKKAEEDKNMALRKAEEAKKaEE 1591
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1761 QNAEEKAKKAAIEAANLSEELKKKQDTIAHLERTRENMEQTITDLQKRLAEAEQMALMGSRKQIQKLESRVRELEGELEG 1840
Cdd:PTZ00121 1592 ARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAE 1671
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1841 EIRRSAEAQRGARRLERCIKELTYQAEEDKKNLSRMQTQMDKLQLKVQNYKQQVEVAETQANQylskYKKQQHELNEVKE 1920
Cdd:PTZ00121 1672 EDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEE----AKKEAEEDKKKAE 1747
                         730       740
                  ....*....|....*....|....*
gi 767926067 1921 RAEVAESQVNKLKIKAREFGKKVQE 1945
Cdd:PTZ00121 1748 EAKKDEEEKKKIAHLKKEEEKKAEE 1772
TOPEUc smart00435
DNA Topoisomerase I (eukaryota); DNA Topoisomerase I (eukaryota), DNA topoisomerase V, Vaccina ...
982-1134 2.09e-03

DNA Topoisomerase I (eukaryota); DNA Topoisomerase I (eukaryota), DNA topoisomerase V, Vaccina virus topoisomerase, Variola virus topoisomerase, Shope fibroma virus topoisomeras


Pssm-ID: 214661 [Multi-domain]  Cd Length: 391  Bit Score: 42.72  E-value: 2.09e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067    982 TTEHKVKNLTEEVEFLNEDISKLNRAAKVVqeA----HQQTLDDLHmeeeklsslSKANLKLEQQVDELEGALEQERKAR 1057
Cdd:smart00435  232 TLQEQLKELTAKDGNVAEKILAYNRANREV--AilcnHQRTVSKTH---------EKSMEKLQEKIKALKYQLKRLKKMI 300
                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767926067   1058 MNCERElhklegnlklnRESMENLESSQRHLAEELRKKELELSQMNSKVENEKGLVAQLQKTVKELQTQIKDlKEKL 1134
Cdd:smart00435  301 LLFEMI-----------SDLKRKLKSKFERDNEKLDAEVKEKKKEKKKEEKKKKQIERLEERIEKLEVQATD-KEEN 365
 
Name Accession Description Interval E-value
MYSc_Myh15_mammals cd14929
class II myosin heavy chain 15, motor domain; Myosin motor domain of sarcomeric myosin heavy ...
117-778 0e+00

class II myosin heavy chain 15, motor domain; Myosin motor domain of sarcomeric myosin heavy chain 15 in mammals (also called KIAA1000) . MYH15 is a slow-twitch myosin. Myh15 is a ventricular myosin heavy chain. Myh15 is absent in embryonic and fetal muscles and is found in orbital layer of extraocular muscles at birth. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276892 [Multi-domain]  Cd Length: 662  Bit Score: 1430.14  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  117 ASVLHTLKRRYGQWMIYTYSGLFCVTINPYKWLPVYQKEVMAAYKGKRRSEAPPHIFAVANNAFQDMLHNRENQSILFTG 196
Cdd:cd14929     1 ASVLHTLRRRYDHWMIYTYSGLFCVTINPYKWLPVYQKEVMAAYKGKRRSEAPPHIFAVANNAFQDMLHNRENQSILFTG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  197 ESGAGKTVNSKHIIQYFATIAAMIESRKKQGALEDQIMQANTILEAFGNAKTLRNDNSSRFGKFIRMHFGARGMLSSVDI 276
Cdd:cd14929    81 ESGAGKTVNTKHIIQYFATIAAMIESKKKLGALEDQIMQANPVLEAFGNAKTLRNDNSSRFGKFIRMHFGARGMLSSADI 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  277 DIYLLEKSRVIFQQAGERNYHIFYQILSGQKELHDLLLVSANPSDFHFCSCGAVTVESLDDAEELLATEQAMDILGFLPD 356
Cdd:cd14929   161 DIYLLEKSRVIFQQPGERNYHIFYQILSGKKELRDLLLVSANPSDFHFCSCGAVAVESLDDAEELLATEQAMDILGFLPD 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  357 EKYGCYKLTGAIMHFGNMKFKQKPREEQLEADGTENADKAAFLMGINSSELVKCLIHPRIKVGNEYVTRGQTIEQVTCAV 436
Cdd:cd14929   241 EKYGCYKLTGAIMHFGNMKFKQKPREEQLEADGTENADKAAFLMGINSSELVKGLIHPRIKVGNEYVTRSQNIEQVTYAV 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  437 GALSKSMYERMFKWLVARINRALDAKLSRQFFIGILDITGFEILEYNSLEQLCINFTNEKLQQFFNWHMFVLEQEEYKKE 516
Cdd:cd14929   321 GALSKSIYERMFKWLVARINRVLDAKLSRQFFIGILDITGFEILDYNSLEQLCINFTNEKLQQFFNQHMFVLEQEEYRKE 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  517 SIEWVSIGFGLDLQACIDLIEKPMGILSILEEECMFPKATDLTFKTKLFDNHFGKSVHLQKPKPDKKKFEAHFELVHYAG 596
Cdd:cd14929   401 GIDWVSIDFGLDLQACIDLIEKPMGIFSILEEECMFPKATDLTFKTKLFDNHFGKSVHFQKPKPDKKKFEAHFELVHYAG 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  597 VVPYNISGWLEKNKDLLNETVVAVFQKSSNRLLASLFENYMSTDSAIPFGEKKRKKGASFQTVASLHKENLNKLMTNLKS 676
Cdd:cd14929   481 VVPYNISGWLEKNKDLLNETVVAVFQKSSNRLLASLFENYISTDSAIQFGEKKRKKGASFQTVASLHKENLNKLMTNLKS 560
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  677 TAPHFVRCINPNVNKIPGILDPYLVLQQLRCNGVLEGTRICREGFPNRLQYADFKQRYCILNPRTFPKSKFVSSRKAAEE 756
Cdd:cd14929   561 TAPHFVRCINPNVNKIPGVLDPYLVLQQLRCNGVLEGIRICREGFPNRLLYADFKQRYCILNPRTFPKSKFVSSRKAAEE 640
                         650       660
                  ....*....|....*....|..
gi 767926067  757 LLGSLEIDHTQYRFGITKVFFK 778
Cdd:cd14929   641 LLGSLEIDHTQYRFGITKVFFK 662
MYSc_class_II cd01377
class II myosins, motor domain; Myosin motor domain in class II myosins. Class II myosins, ...
117-778 0e+00

class II myosins, motor domain; Myosin motor domain in class II myosins. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. Thus, myosin II has two heads. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276951 [Multi-domain]  Cd Length: 662  Bit Score: 1244.27  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  117 ASVLHTLKRRYGQWMIYTYSGLFCVTINPYKWLPVYQKEVMAAYKGKRRSEAPPHIFAVANNAFQDMLHNRENQSILFTG 196
Cdd:cd01377     1 ASVLHNLRERYYSDLIYTYSGLFCVAVNPYKRLPIYTEEVIDKYKGKRREEMPPHIFAIADNAYRNMLQDRENQSILITG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  197 ESGAGKTVNSKHIIQYFATIAAMIESR----KKQGALEDQIMQANTILEAFGNAKTLRNDNSSRFGKFIRMHFGARGMLS 272
Cdd:cd01377    81 ESGAGKTENTKKVIQYLASVAASSKKKkesgKKKGTLEDQILQANPILEAFGNAKTVRNNNSSRFGKFIRIHFGSTGKIA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  273 SVDIDIYLLEKSRVIFQQAGERNYHIFYQILSGQK-ELHDLLLVSANPSDFHFCSCGAVTVESLDDAEELLATEQAMDIL 351
Cdd:cd01377   161 GADIETYLLEKSRVVRQAKGERNYHIFYQLLSGADpELKEKLLLTGDPSYYFFLSQGELTIDGVDDAEEFKLTDEAFDIL 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  352 GFLPDEKYGCYKLTGAIMHFGNMKFKQKPREEQLEADGTENADKAAFLMGINSSELVKCLIHPRIKVGNEYVTRGQTIEQ 431
Cdd:cd01377   241 GFSEEEKMSIFKIVAAILHLGNIKFKQRRREEQAELDGTEEADKAAHLLGVNSSDLLKALLKPRIKVGREWVTKGQNKEQ 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  432 VTCAVGALSKSMYERMFKWLVARINRALDAKLSRQFFIGILDITGFEILEYNSLEQLCINFTNEKLQQFFNWHMFVLEQE 511
Cdd:cd01377   321 VVFSVGALAKALYERLFLWLVKRINKTLDTKSKRQYFIGVLDIAGFEIFEFNSFEQLCINYTNEKLQQFFNHHMFVLEQE 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  512 EYKKESIEWVSIGFGLDLQACIDLIEKP-MGILSILEEECMFPKATDLTFKTKLFDNHFGKSVHLQKPKPdkKKFEAHFE 590
Cdd:cd01377   401 EYKKEGIEWTFIDFGLDLQPTIDLIEKPnMGILSILDEECVFPKATDKTFVEKLYSNHLGKSKNFKKPKP--KKSEAHFI 478
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  591 LVHYAGVVPYNISGWLEKNKDLLNETVVAVFQKSSNRLLASLFENYMSTDSAipfGEKKRKKGASFQTVASLHKENLNKL 670
Cdd:cd01377   479 LKHYAGDVEYNIDGWLEKNKDPLNENVVALLKKSSDPLVASLFKDYEESGGG---GGKKKKKGGSFRTVSQLHKEQLNKL 555
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  671 MTNLKSTAPHFVRCINPNVNKIPGILDPYLVLQQLRCNGVLEGTRICREGFPNRLQYADFKQRYCILNPRTFPKSkFVSS 750
Cdd:cd01377   556 MTTLRSTHPHFVRCIIPNEEKKPGKIDAPLVLHQLRCNGVLEGIRICRKGFPNRIIFAEFKQRYSILAPNAIPKG-FDDG 634
                         650       660
                  ....*....|....*....|....*...
gi 767926067  751 RKAAEELLGSLEIDHTQYRFGITKVFFK 778
Cdd:cd01377   635 KAACEKILKALQLDPELYRIGNTKVFFK 662
MYSc_Myh7b cd14927
class II myosin heavy chain 7b, motor domain; Myosin motor domain of cardiac muscle, beta ...
117-778 0e+00

class II myosin heavy chain 7b, motor domain; Myosin motor domain of cardiac muscle, beta myosin heavy chain 7b (also called KIAA1512, dJ756N5.1, MYH14, MHC14). MYH7B is a slow-twitch myosin. Mutations in this gene result in one form of autosomal dominant hearing impairment. Multiple transcript variants encoding different isoforms have been found for this gene. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276953 [Multi-domain]  Cd Length: 676  Bit Score: 1179.36  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  117 ASVLHTLKRRYGQWMIYTYSGLFCVTINPYKWLPVYQKEVMAAYKGKRRSEAPPHIFAVANNAFQDMLHNRENQSILFTG 196
Cdd:cd14927     1 ASVLHNLRRRYSRWMIYTYSGLFCVTVNPYKWLPVYTAPVVAAYKGKRRSEAPPHIYAIADNAYNDMLRNRENQSMLITG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  197 ESGAGKTVNSKHIIQYFATIAAMIESRKKQ---------GALEDQIMQANTILEAFGNAKTLRNDNSSRFGKFIRMHFGA 267
Cdd:cd14927    81 ESGAGKTVNTKRVIQYFAIVAALGDGPGKKaqflatktgGTLEDQIIEANPAMEAFGNAKTLRNDNSSRFGKFIRIHFGP 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  268 RGMLSSVDIDIYLLEKSRVIFQQAGERNYHIFYQILSGQK-ELHDLLLVSANPSDFHFCSCGAVTVESLDDAEELLATEQ 346
Cdd:cd14927   161 TGKLASADIDIYLLEKSRVIFQQPGERSYHIYYQILSGKKpELQDMLLVSMNPYDYHFCSQGVTTVDNMDDGEELMATDH 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  347 AMDILGFLPDEKYGCYKLTGAIMHFGNMKFKQKPREEQLEADGTENADKAAFLMGINSSELVKCLIHPRIKVGNEYVTRG 426
Cdd:cd14927   241 AMDILGFSPDEKYGCYKIVGAIMHFGNMKFKQKQREEQAEADGTESADKAAYLMGVSSADLLKGLLHPRVKVGNEYVTKG 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  427 QTIEQVTCAVGALSKSMYERMFKWLVARINRALDAKLSRQFFIGILDITGFEILEYNSLEQLCINFTNEKLQQFFNWHMF 506
Cdd:cd14927   321 QSVEQVVYAVGALAKATYDRMFKWLVSRINQTLDTKLPRQFFIGVLDIAGFEIFEFNSFEQLCINFTNEKLQQFFNHHMF 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  507 VLEQEEYKKESIEWVSIGFGLDLQACIDLIEKPMGILSILEEECMFPKATDLTFKTKLFDNHFGKSVHLQKPKPDKK-KF 585
Cdd:cd14927   401 ILEQEEYKREGIEWVFIDFGLDLQACIDLIEKPLGILSILEEECMFPKASDASFKAKLYDNHLGKSPNFQKPRPDKKrKY 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  586 EAHFELVHYAGVVPYNISGWLEKNKDLLNETVVAVFQKSSNRLLASLFENYMSTDSAIPFG---EKKRKKGASFQTVASL 662
Cdd:cd14927   481 EAHFEVVHYAGVVPYNIVGWLDKNKDPLNETVVAIFQKSQNKLLATLYENYVGSDSTEDPKsgvKEKRKKAASFQTVSQL 560
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  663 HKENLNKLMTNLKSTAPHFVRCINPNVNKIPGILDPYLVLQQLRCNGVLEGTRICREGFPNRLQYADFKQRYCILNPRTF 742
Cdd:cd14927   561 HKENLNKLMTNLRATQPHFVRCIIPNETKTPGVMDPFLVLHQLRCNGVLEGIRICRKGFPNRILYADFKQRYRILNPSAI 640
                         650       660       670
                  ....*....|....*....|....*....|....*.
gi 767926067  743 PKSKFVSSRKAAEELLGSLEIDHTQYRFGITKVFFK 778
Cdd:cd14927   641 PDDKFVDSRKATEKLLGSLDIDHTQYQFGHTKVFFK 676
MYSc_Myh3 cd14913
class II myosin heavy chain 3, motor domain; Myosin motor domain of fetal skeletal muscle ...
118-778 0e+00

class II myosin heavy chain 3, motor domain; Myosin motor domain of fetal skeletal muscle myosin heavy chain 3 (MYHC-EMB, MYHSE1, HEMHC, SMHCE) in tetrapods including mammals, lizards, and frogs. This gene is a member of the MYH family and encodes a protein with an IQ domain and a myosin head-like domain. Mutations in this gene have been associated with two congenital contracture (arthrogryposis) syndromes, Freeman-Sheldon syndrome and Sheldon-Hall syndrome. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276878 [Multi-domain]  Cd Length: 668  Bit Score: 1066.98  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  118 SVLHTLKRRYGQWMIYTYSGLFCVTINPYKWLPVYQKEVMAAYKGKRRSEAPPHIFAVANNAFQDMLHNRENQSILFTGE 197
Cdd:cd14913     2 AVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPVYNPEVVEGYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGE 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  198 SGAGKTVNSKHIIQYFATIAAMIESRKKQ-----GALEDQIMQANTILEAFGNAKTLRNDNSSRFGKFIRMHFGARGMLS 272
Cdd:cd14913    82 SGAGKTVNTKRVIQYFATIAATGDLAKKKdskmkGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLA 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  273 SVDIDIYLLEKSRVIFQQAGERNYHIFYQILSGQK-ELHDLLLVSANPSDFHFCSCGAVTVESLDDAEELLATEQAMDIL 351
Cdd:cd14913   162 SADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKpELIELLLITTNPYDYPFISQGEILVASIDDAEELLATDSAIDIL 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  352 GFLPDEKYGCYKLTGAIMHFGNMKFKQKPREEQLEADGTENADKAAFLMGINSSELVKCLIHPRIKVGNEYVTRGQTIEQ 431
Cdd:cd14913   242 GFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKTAYLMGLNSSDLLKALCFPRVKVGNEYVTKGQTVDQ 321
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  432 VTCAVGALSKSMYERMFKWLVARINRALDAKLSRQFFIGILDITGFEILEYNSLEQLCINFTNEKLQQFFNWHMFVLEQE 511
Cdd:cd14913   322 VHHAVNALSKSVYEKLFLWMVTRINQQLDTKLPRQHFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQFFNHHMFVLEQE 401
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  512 EYKKESIEWVSIGFGLDLQACIDLIEKPMGILSILEEECMFPKATDLTFKTKLFDNHFGKSVHLQKPKPDKKKFEAHFEL 591
Cdd:cd14913   402 EYKKEGIEWTFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQKPKVVKGRAEAHFSL 481
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  592 VHYAGVVPYNISGWLEKNKDLLNETVVAVFQKSSNRLLASLFENYMSTDSAIPFGEKKRKKGASFQTVASLHKENLNKLM 671
Cdd:cd14913   482 IHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLYATFATADADSGKKKVAKKKGSSFQTVSALFRENLNKLM 561
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  672 TNLKSTAPHFVRCINPNVNKIPGILDPYLVLQQLRCNGVLEGTRICREGFPNRLQYADFKQRYCILNPRTFPKSKFVSSR 751
Cdd:cd14913   562 SNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRVLNASAIPEGQFIDSK 641
                         650       660
                  ....*....|....*....|....*..
gi 767926067  752 KAAEELLGSLEIDHTQYRFGITKVFFK 778
Cdd:cd14913   642 KACEKLLASIDIDHTQYKFGHTKVFFK 668
MYSc_Myh7 cd14917
class II myosin heavy chain 7, motor domain; Myosin motor domain of beta (or slow) type I ...
118-778 0e+00

class II myosin heavy chain 7, motor domain; Myosin motor domain of beta (or slow) type I cardiac muscle myosin heavy chain 7 (also called CMH1, MPD1, and CMD1S). Muscle myosin is a hexameric protein containing 2 heavy chain subunits, 2 alkali light chain subunits, and 2 regulatory light chain subunits. It is expressed predominantly in normal human ventrical and in skeletal muscle tissues rich in slow-twitch type I muscle fibers. Changes in the relative abundance of this protein and the alpha (or fast) heavy subunit of cardiac myosin correlate with the contractile velocity of cardiac muscle. Its expression is also altered during thyroid hormone depletion and hemodynamic overloading. Mutations in this gene are associated with familial hypertrophic cardiomyopathy, myosin storage myopathy, dilated cardiomyopathy, and Laing early-onset distal myopathy. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276881 [Multi-domain]  Cd Length: 668  Bit Score: 986.14  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  118 SVLHTLKRRYGQWMIYTYSGLFCVTINPYKWLPVYQKEVMAAYKGKRRSEAPPHIFAVANNAFQDMLHNRENQSILFTGE 197
Cdd:cd14917     2 AVLYNLKERYASWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGE 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  198 SGAGKTVNSKHIIQYFATIAAMIESRKK-----QGALEDQIMQANTILEAFGNAKTLRNDNSSRFGKFIRMHFGARGMLS 272
Cdd:cd14917    82 SGAGKTVNTKRVIQYFAVIAAIGDRSKKdqtpgKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLA 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  273 SVDIDIYLLEKSRVIFQQAGERNYHIFYQILSGQK-ELHDLLLVSANPSDFHFCSCGAVTVESLDDAEELLATEQAMDIL 351
Cdd:cd14917   162 SADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKpELLDMLLITNNPYDYAFISQGETTVASIDDAEELMATDNAFDVL 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  352 GFLPDEKYGCYKLTGAIMHFGNMKFKQKPREEQLEADGTENADKAAFLMGINSSELVKCLIHPRIKVGNEYVTRGQTIEQ 431
Cdd:cd14917   242 GFTSEEKNSMYKLTGAIMHFGNMKFKQKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNVQQ 321
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  432 VTCAVGALSKSMYERMFKWLVARINRALDAKLSRQFFIGILDITGFEILEYNSLEQLCINFTNEKLQQFFNWHMFVLEQE 511
Cdd:cd14917   322 VIYATGALAKAVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQE 401
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  512 EYKKESIEWVSIGFGLDLQACIDLIEKPMGILSILEEECMFPKATDLTFKTKLFDNHFGKSVHLQKPKPDKKKFEAHFEL 591
Cdd:cd14917   402 EYKKEGIEWTFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLFDNHLGKSNNFQKPRNIKGKPEAHFSL 481
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  592 VHYAGVVPYNISGWLEKNKDLLNETVVAVFQKSSNRLLASLFENYMSTDSAIPFGEKKRKKGASFQTVASLHKENLNKLM 671
Cdd:cd14917   482 IHYAGTVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSNLFANYAGADAPIEKGKGKAKKGSSFQTVSALHRENLNKLM 561
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  672 TNLKSTAPHFVRCINPNVNKIPGILDPYLVLQQLRCNGVLEGTRICREGFPNRLQYADFKQRYCILNPRTFPKSKFVSSR 751
Cdd:cd14917   562 TNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQFIDSR 641
                         650       660
                  ....*....|....*....|....*..
gi 767926067  752 KAAEELLGSLEIDHTQYRFGITKVFFK 778
Cdd:cd14917   642 KGAEKLLSSLDIDHNQYKFGHTKVFFK 668
MYSc_Myh6 cd14916
class II myosin heavy chain 6, motor domain; Myosin motor domain of alpha (or fast) cardiac ...
118-778 0e+00

class II myosin heavy chain 6, motor domain; Myosin motor domain of alpha (or fast) cardiac muscle myosin heavy chain 6. Cardiac muscle myosin is a hexamer consisting of two heavy chain subunits, two light chain subunits, and two regulatory subunits. This gene encodes the alpha heavy chain subunit of cardiac myosin. Mutations in this gene cause familial hypertrophic cardiomyopathy and atrial septal defect. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276880 [Multi-domain]  Cd Length: 670  Bit Score: 961.44  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  118 SVLHTLKRRYGQWMIYTYSGLFCVTINPYKWLPVYQKEVMAAYKGKRRSEAPPHIFAVANNAFQDMLHNRENQSILFTGE 197
Cdd:cd14916     2 AVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGE 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  198 SGAGKTVNSKHIIQYFATIAAMIESRKK------QGALEDQIMQANTILEAFGNAKTLRNDNSSRFGKFIRMHFGARGML 271
Cdd:cd14916    82 SGAGKTVNTKRVIQYFASIAAIGDRSKKenpnanKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKL 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  272 SSVDIDIYLLEKSRVIFQQAGERNYHIFYQILSGQK-ELHDLLLVSANPSDFHFCSCGAVTVESLDDAEELLATEQAMDI 350
Cdd:cd14916   162 ASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKpELLDMLLVTNNPYDYAFVSQGEVSVASIDDSEELLATDSAFDV 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  351 LGFLPDEKYGCYKLTGAIMHFGNMKFKQKPREEQLEADGTENADKAAFLMGINSSELVKCLIHPRIKVGNEYVTRGQTIE 430
Cdd:cd14916   242 LGFTAEEKAGVYKLTGAIMHYGNMKFKQKQREEQAEPDGTEDADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQSVQ 321
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  431 QVTCAVGALSKSMYERMFKWLVARINRALDAKLSRQFFIGILDITGFEILEYNSLEQLCINFTNEKLQQFFNWHMFVLEQ 510
Cdd:cd14916   322 QVYYSIGALAKSVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQ 401
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  511 EEYKKESIEWVSIGFGLDLQACIDLIEKPMGILSILEEECMFPKATDLTFKTKLFDNHFGKSVHLQKPKPDKKKFEAHFE 590
Cdd:cd14916   402 EEYKKEGIEWEFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKASDMTFKAKLYDNHLGKSNNFQKPRNVKGKQEAHFS 481
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  591 LVHYAGVVPYNISGWLEKNKDLLNETVVAVFQKSSNRLLASLFENYMSTDSAIP-FGEKKRKKGASFQTVASLHKENLNK 669
Cdd:cd14916   482 LVHYAGTVDYNILGWLEKNKDPLNETVVGLYQKSSLKLMATLFSTYASADTGDSgKGKGGKKKGSSFQTVSALHRENLNK 561
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  670 LMTNLKSTAPHFVRCINPNVNKIPGILDPYLVLQQLRCNGVLEGTRICREGFPNRLQYADFKQRYCILNPRTFPKSKFVS 749
Cdd:cd14916   562 LMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQFID 641
                         650       660
                  ....*....|....*....|....*....
gi 767926067  750 SRKAAEELLGSLEIDHTQYRFGITKVFFK 778
Cdd:cd14916   642 SRKGAEKLLGSLDIDHNQYKFGHTKVFFK 670
Myosin_head pfam00063
Myosin head (motor domain);
105-778 0e+00

Myosin head (motor domain);


Pssm-ID: 395017 [Multi-domain]  Cd Length: 674  Bit Score: 959.81  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   105 IEDMAMLTHLNEASVLHTLKRRYGQWMIYTYSGLFCVTINPYKWLPVYQKEVMAAYKGKRRSEAPPHIFAVANNAFQDML 184
Cdd:pfam00063    1 VEDMVELSYLNEPSVLHNLKKRYKSDLIYTYSGLVLVAVNPYKQLPIYSEDMIKAYRGKRRGELPPHIFAIADEAYRSML 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   185 HNRENQSILFTGESGAGKTVNSKHIIQYFATIAAmIESRKKQGALEDQIMQANTILEAFGNAKTLRNDNSSRFGKFIRMH 264
Cdd:pfam00063   81 QDKENQSILISGESGAGKTENTKKIMQYLASVSG-SGSAGNVGRLEEQILQSNPILEAFGNAKTVRNNNSSRFGKYIEIQ 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   265 FGARGMLSSVDIDIYLLEKSRVIFQQAGERNYHIFYQILSG--QKELHDLLLvsANPSDFHFCS-CGAVTVESLDDAEEL 341
Cdd:pfam00063  160 FDAKGDIVGGKIETYLLEKSRVVYQAEGERNYHIFYQLLAGasAQLKKELRL--TNPKDYHYLSqSGCYTIDGIDDSEEF 237
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   342 LATEQAMDILGFLPDEKYGCYKLTGAIMHFGNMKFKQKPREEQLEADGTENADKAAFLMGINSSELVKCLIHPRIKVGNE 421
Cdd:pfam00063  238 KITDKAMDILGFSDEEQMGIFRIVAAILHLGNIEFKKERNDEQAVPDDTENLQKAASLLGIDSTELEKALCKRRIKTGRE 317
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   422 YVTRGQTIEQVTCAVGALSKSMYERMFKWLVARINRALDAK-LSRQFFIGILDITGFEILEYNSLEQLCINFTNEKLQQF 500
Cdd:pfam00063  318 TVSKPQNVEQANYARDALAKAIYSRLFDWLVDRINKSLDVKtIEKASFIGVLDIYGFEIFEKNSFEQLCINYVNEKLQQF 397
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   501 FNWHMFVLEQEEYKKESIEWVSIGFGlDLQACIDLIE-KPMGILSILEEECMFPKATDLTFKTKLFDnHFGKSVHLQKPK 579
Cdd:pfam00063  398 FNHHMFKLEQEEYVREGIEWTFIDFG-DNQPCIDLIEkKPLGILSLLDEECLFPKATDQTFLDKLYS-TFSKHPHFQKPR 475
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   580 PdkkKFEAHFELVHYAGVVPYNISGWLEKNKDLLNETVVAVFQKSSNRLLASLFENYMSTDSAIPFGE----KKRKKGAS 655
Cdd:pfam00063  476 L---QGETHFIIKHYAGDVEYNVEGFLEKNKDPLNDDLVSLLKSSSDPLLAELFPDYETAESAAANESgkstPKRTKKKR 552
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   656 FQTVASLHKENLNKLMTNLKSTAPHFVRCINPNVNKIPGILDPYLVLQQLRCNGVLEGTRICREGFPNRLQYADFKQRYC 735
Cdd:pfam00063  553 FITVGSQFKESLGELMKTLNSTNPHYIRCIKPNEKKRAGVFDNSLVLHQLRCNGVLEGIRIRRAGFPNRITFQEFVQRYR 632
                          650       660       670       680
                   ....*....|....*....|....*....|....*....|...
gi 767926067   736 ILNPRTFPKSkFVSSRKAAEELLGSLEIDHTQYRFGITKVFFK 778
Cdd:pfam00063  633 ILAPKTWPKW-KGDAKKGCEAILQSLNLDKEEYQFGKTKIFFR 674
MYSc_Myh13 cd14923
class II myosin heavy chain 13, motor domain; Myosin motor domain of skeletal muscle myosin ...
118-778 0e+00

class II myosin heavy chain 13, motor domain; Myosin motor domain of skeletal muscle myosin heavy chain 13 (also called MyHC-eo) in mammals, chicken, and green anole. Myh13 is a myosin whose expression is restricted primarily to the extrinsic eye muscles which are specialized for function in eye movement. Class II myosins, also called conventional myosins, are the myosin type responsible for producing muscle contraction in muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276887 [Multi-domain]  Cd Length: 671  Bit Score: 954.90  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  118 SVLHTLKRRYGQWMIYTYSGLFCVTINPYKWLPVYQKEVMAAYKGKRRSEAPPHIFAVANNAFQDMLHNRENQSILFTGE 197
Cdd:cd14923     2 AVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVAAYRGKKRQEAPPHIFSISDNAYQFMLTDRDNQSILITGE 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  198 SGAGKTVNSKHIIQYFATIAAMIESRKK------QGALEDQIMQANTILEAFGNAKTLRNDNSSRFGKFIRMHFGARGML 271
Cdd:cd14923    82 SGAGKTVNTKRVIQYFATIAVTGDKKKEqqpgkmQGTLEDQIIQANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGATGKL 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  272 SSVDIDIYLLEKSRVIFQQAGERNYHIFYQILSGQK-ELHDLLLVSANPSDFHFCSCGAVTVESLDDAEELLATEQAMDI 350
Cdd:cd14923   162 ASADIETYLLEKSRVTFQLSSERSYHIFYQIMSNKKpELIDLLLISTNPFDFPFVSQGEVTVASIDDSEELLATDNAIDI 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  351 LGFLPDEKYGCYKLTGAIMHFGNMKFKQKPREEQLEADGTENADKAAFLMGINSSELVKCLIHPRIKVGNEYVTRGQTIE 430
Cdd:cd14923   242 LGFSSEEKVGIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAGYLMGLNSAEMLKGLCCPRVKVGNEYVTKGQNVQ 321
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  431 QVTCAVGALSKSMYERMFKWLVARINRALDAKLSRQFFIGILDITGFEILEYNSLEQLCINFTNEKLQQFFNWHMFVLEQ 510
Cdd:cd14923   322 QVTNSVGALAKAVYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQ 401
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  511 EEYKKESIEWVSIGFGLDLQACIDLIEKPMGILSILEEECMFPKATDLTFKTKLFDNHFGKSVHLQKPKPDKKKFEAHFE 590
Cdd:cd14923   402 EEYKKEGIEWEFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQKPKPAKGKAEAHFS 481
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  591 LVHYAGVVPYNISGWLEKNKDLLNETVVAVFQKSSNRLLASLFENYMSTDSAIPFGEKK--RKKGASFQTVASLHKENLN 668
Cdd:cd14923   482 LVHYAGTVDYNIAGWLDKNKDPLNETVVGLYQKSSLKLLSFLFSNYAGAEAGDSGGSKKggKKKGSSFQTVSAVFRENLN 561
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  669 KLMTNLKSTAPHFVRCINPNVNKIPGILDPYLVLQQLRCNGVLEGTRICREGFPNRLQYADFKQRYCILNPRTFPKSKFV 748
Cdd:cd14923   562 KLMTNLRSTHPHFVRCLIPNETKTPGVMDHYLVMHQLRCNGVLEGIRICRKGFPSRILYADFKQRYRILNASAIPEGQFI 641
                         650       660       670
                  ....*....|....*....|....*....|
gi 767926067  749 SSRKAAEELLGSLEIDHTQYRFGITKVFFK 778
Cdd:cd14923   642 DSKNASEKLLNSIDVDREQYRFGHTKVFFK 671
MYSc_Myh8 cd14918
class II myosin heavy chain 8, motor domain; Myosin motor domain of perinatal skeletal muscle ...
119-778 0e+00

class II myosin heavy chain 8, motor domain; Myosin motor domain of perinatal skeletal muscle myosin heavy chain 8 (also called MyHC-peri, MyHC-pn). Myosin is a hexameric protein composed of a pair of myosin heavy chains (MYH) and two pairs of nonidentical light chains. A mutation in this gene results in trismus-pseudocamptodactyly syndrome. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276882 [Multi-domain]  Cd Length: 668  Bit Score: 936.08  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  119 VLHTLKRRYGQWMIYTYSGLFCVTINPYKWLPVYQKEVMAAYKGKRRSEAPPHIFAVANNAFQDMLHNRENQSILFTGES 198
Cdd:cd14918     3 VLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVAAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGES 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  199 GAGKTVNSKHIIQYFATIAAMIESRKK-----QGALEDQIMQANTILEAFGNAKTLRNDNSSRFGKFIRMHFGARGMLSS 273
Cdd:cd14918    83 GAGKTVNTKRVIQYFATIAVTGEKKKEesgkmQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLAS 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  274 VDIDIYLLEKSRVIFQQAGERNYHIFYQILSGQK-ELHDLLLVSANPSDFHFCSCGAVTVESLDDAEELLATEQAMDILG 352
Cdd:cd14918   163 ADIETYLLEKSRVTFQLKAERSYHIFYQITSNKKpDLIEMLLITTNPYDYAFVSQGEITVPSIDDQEELMATDSAIDILG 242
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  353 FLPDEKYGCYKLTGAIMHFGNMKFKQKPREEQLEADGTENADKAAFLMGINSSELVKCLIHPRIKVGNEYVTRGQTIEQV 432
Cdd:cd14918   243 FTPEEKVSIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAAYLQSLNSADLLKALCYPRVKVGNEYVTKGQTVQQV 322
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  433 TCAVGALSKSMYERMFKWLVARINRALDAKLSRQFFIGILDITGFEILEYNSLEQLCINFTNEKLQQFFNWHMFVLEQEE 512
Cdd:cd14918   323 YNAVGALAKAVYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEE 402
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  513 YKKESIEWVSIGFGLDLQACIDLIEKPMGILSILEEECMFPKATDLTFKTKLFDNHFGKSVHLQKPKPDKKKFEAHFELV 592
Cdd:cd14918   403 YKKEGIEWTFIDFGMDLAACIELIEKPLGIFSILEEECMFPKATDTSFKNKLYDQHLGKSANFQKPKVVKGKAEAHFSLI 482
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  593 HYAGVVPYNISGWLEKNKDLLNETVVAVFQKSSNRLLASLFENYMSTDSAIPFGEKKRKKGASFQTVASLHKENLNKLMT 672
Cdd:cd14918   483 HYAGTVDYNITGWLDKNKDPLNDTVVGLYQKSAMKTLASLFSTYASAEADSGAKKGAKKKGSSFQTVSALFRENLNKLMT 562
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  673 NLKSTAPHFVRCINPNVNKIPGILDPYLVLQQLRCNGVLEGTRICREGFPNRLQYADFKQRYCILNPRTFPKSKFVSSRK 752
Cdd:cd14918   563 NLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYGDFKQRYKVLNASAIPEGQFIDSKK 642
                         650       660
                  ....*....|....*....|....*.
gi 767926067  753 AAEELLGSLEIDHTQYRFGITKVFFK 778
Cdd:cd14918   643 ASEKLLASIDIDHTQYKFGHTKVFFK 668
MYSc_Myh4 cd14915
class II myosin heavy chain 4, motor domain; Myosin motor domain of skeletal muscle myosin ...
118-778 0e+00

class II myosin heavy chain 4, motor domain; Myosin motor domain of skeletal muscle myosin heavy chain 4 (also called MYH2B, MyHC-2B, MyHC-IIb). Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276879 [Multi-domain]  Cd Length: 671  Bit Score: 934.53  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  118 SVLHTLKRRYGQWMIYTYSGLFCVTINPYKWLPVYQKEVMAAYKGKRRSEAPPHIFAVANNAFQDMLHNRENQSILFTGE 197
Cdd:cd14915     2 AVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVTAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGE 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  198 SGAGKTVNSKHIIQYFATIAAMIESRKK-------QGALEDQIMQANTILEAFGNAKTLRNDNSSRFGKFIRMHFGARGM 270
Cdd:cd14915    82 SGAGKTVNTKRVIQYFATIAVTGEKKKEeaasgkmQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGATGK 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  271 LSSVDIDIYLLEKSRVIFQQAGERNYHIFYQILSGQK-ELHDLLLVSANPSDFHFCSCGAVTVESLDDAEELLATEQAMD 349
Cdd:cd14915   162 LASADIETYLLEKSRVTFQLKAERSYHIFYQIMSNKKpELIEMLLITTNPYDFAFVSQGEITVPSIDDQEELMATDSAVD 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  350 ILGFLPDEKYGCYKLTGAIMHFGNMKFKQKPREEQLEADGTENADKAAFLMGINSSELVKCLIHPRIKVGNEYVTRGQTI 429
Cdd:cd14915   242 ILGFSADEKVAIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAAYLTSLNSADLLKALCYPRVKVGNEYVTKGQTV 321
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  430 EQVTCAVGALSKSMYERMFKWLVARINRALDAKLSRQFFIGILDITGFEILEYNSLEQLCINFTNEKLQQFFNWHMFVLE 509
Cdd:cd14915   322 QQVYNSVGALAKAIYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLE 401
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  510 QEEYKKESIEWVSIGFGLDLQACIDLIEKPMGILSILEEECMFPKATDLTFKTKLFDNHFGKSVHLQKPKPDKKKFEAHF 589
Cdd:cd14915   402 QEEYKKEGIEWEFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYEQHLGKSNNFQKPKPAKGKAEAHF 481
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  590 ELVHYAGVVPYNISGWLEKNKDLLNETVVAVFQKSSNRLLASLFENYMSTDSAIPFGEK-KRKKGASFQTVASLHKENLN 668
Cdd:cd14915   482 SLVHYAGTVDYNIAGWLDKNKDPLNETVVGLYQKSGMKTLAFLFSGGQTAEAEGGGGKKgGKKKGSSFQTVSALFRENLN 561
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  669 KLMTNLKSTAPHFVRCINPNVNKIPGILDPYLVLQQLRCNGVLEGTRICREGFPNRLQYADFKQRYCILNPRTFPKSKFV 748
Cdd:cd14915   562 KLMTNLRSTHPHFVRCLIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASAIPEGQFI 641
                         650       660       670
                  ....*....|....*....|....*....|
gi 767926067  749 SSRKAAEELLGSLEIDHTQYRFGITKVFFK 778
Cdd:cd14915   642 DSKKASEKLLGSIDIDHTQYKFGHTKVFFK 671
MYSc smart00242
Myosin. Large ATPases; ATPase; molecular motor. Muscle contraction consists of a cyclical ...
98-790 0e+00

Myosin. Large ATPases; ATPase; molecular motor. Muscle contraction consists of a cyclical interaction between myosin and actin. The core of the myosin structure is similar in fold to that of kinesin.


Pssm-ID: 214580 [Multi-domain]  Cd Length: 677  Bit Score: 933.11  E-value: 0e+00
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067     98 NPPEFEMIEDMAMLTHLNEASVLHTLKRRYGQWMIYTYSGLFCVTINPYKWLPVYQKEVMAAYKGKRRSEAPPHIFAVAN 177
Cdd:smart00242    1 NPPKFEGVEDLVLLTYLNEPAVLHNLKKRYLKDLIYTYIGLVLVAVNPYKQLPIYTDEVIKKYRGKSRGELPPHVFAIAD 80
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067    178 NAFQDMLHNRENQSILFTGESGAGKTVNSKHIIQYFATIAAmieSRKKQGALEDQIMQANTILEAFGNAKTLRNDNSSRF 257
Cdd:smart00242   81 NAYRNMLNDKENQSIIISGESGAGKTENTKKIMQYLASVSG---SNTEVGSVEDQILESNPILEAFGNAKTLRNNNSSRF 157
                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067    258 GKFIRMHFGARGMLSSVDIDIYLLEKSRVIFQQAGERNYHIFYQILSG--QKELHDLLLvsANPSDFHFCS-CGAVTVES 334
Cdd:smart00242  158 GKFIEIHFDAKGKIIGAKIETYLLEKSRVVSQAKGERNYHIFYQLLAGasEELKKELGL--KSPEDYRYLNqGGCLTVDG 235
                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067    335 LDDAEELLATEQAMDILGFLPDEKYGCYKLTGAIMHFGNMKFKQKPREEQLEA-DGTENADKAAFLMGINSSELVKCLIH 413
Cdd:smart00242  236 IDDAEEFKETLNAMRVLGFSEEEQESIFKILAAILHLGNIEFEEGRNDNAASTvKDKEELSNAAELLGVDPEELEKALTK 315
                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067    414 PRIKVGNEYVTRGQTIEQVTCAVGALSKSMYERMFKWLVARINRALDAKLSRQFFIGILDITGFEILEYNSLEQLCINFT 493
Cdd:smart00242  316 RKIKTGGEVITKPLNVEQALDARDALAKALYSRLFDWLVKRINQSLSFKDGSTYFIGVLDIYGFEIFEVNSFEQLCINYA 395
                           410       420       430       440       450       460       470       480
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067    494 NEKLQQFFNWHMFVLEQEEYKKESIEWVSIGFGlDLQACIDLIE-KPMGILSILEEECMFPKATDLTFKTKLfDNHFGKS 572
Cdd:smart00242  396 NEKLQQFFNQHVFKLEQEEYEREGIDWTFIDFF-DNQDCIDLIEkKPPGILSLLDEECRFPKGTDQTFLEKL-NQHHKKH 473
                           490       500       510       520       530       540       550       560
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067    573 VHLQKPkpdKKKFEAHFELVHYAGVVPYNISGWLEKNKDLLNETVVAVFQKSSNRLLASLFENYmstdsaipfgEKKRKK 652
Cdd:smart00242  474 PHFSKP---KKKGRTEFIIKHYAGDVTYDVTGFLEKNKDTLSDDLIELLQSSKNPLIASLFPSG----------VSNAGS 540
                           570       580       590       600       610       620       630       640
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067    653 GASFQTVASLHKENLNKLMTNLKSTAPHFVRCINPNVNKIPGILDPYLVLQQLRCNGVLEGTRICREGFPNRLQYADFKQ 732
Cdd:smart00242  541 KKRFQTVGSQFKEQLNELMDTLNSTNPHFIRCIKPNEEKKPGDFDSSLVLHQLRYLGVLENIRIRRAGFPYRLPFDEFLQ 620
                           650       660       670       680       690
                    ....*....|....*....|....*....|....*....|....*....|....*...
gi 767926067    733 RYCILNPRTFPkSKFVSSRKAAEELLGSLEIDHTQYRFGITKVFFKAGFLGQLEAIRD 790
Cdd:smart00242  621 RYRVLLPDTWP-PWGGDAKKACEALLQSLGLDEDEYQLGKTKVFLRPGQLAELEELRE 677
MYSc_Myh1_mammals cd14910
class II myosin heavy chain 1, motor domain; Myosin motor domain of type IIx skeletal muscle ...
118-778 0e+00

class II myosin heavy chain 1, motor domain; Myosin motor domain of type IIx skeletal muscle myosin heavy chain 1 (also called MYHSA1, MYHa, MyHC-2X/D, MGC133384) in mammals. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276875 [Multi-domain]  Cd Length: 671  Bit Score: 931.07  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  118 SVLHTLKRRYGQWMIYTYSGLFCVTINPYKWLPVYQKEVMAAYKGKRRSEAPPHIFAVANNAFQDMLHNRENQSILFTGE 197
Cdd:cd14910     2 AVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVTAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGE 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  198 SGAGKTVNSKHIIQYFATIAAM-------IESRKKQGALEDQIMQANTILEAFGNAKTLRNDNSSRFGKFIRMHFGARGM 270
Cdd:cd14910    82 SGAGKTVNTKRVIQYFATIAVTgekkkeeATSGKMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGK 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  271 LSSVDIDIYLLEKSRVIFQQAGERNYHIFYQILSGQK-ELHDLLLVSANPSDFHFCSCGAVTVESLDDAEELLATEQAMD 349
Cdd:cd14910   162 LASADIETYLLEKSRVTFQLKAERSYHIFYQIMSNKKpDLIEMLLITTNPYDYAFVSQGEITVPSIDDQEELMATDSAIE 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  350 ILGFLPDEKYGCYKLTGAIMHFGNMKFKQKPREEQLEADGTENADKAAFLMGINSSELVKCLIHPRIKVGNEYVTRGQTI 429
Cdd:cd14910   242 ILGFTSDERVSIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAAYLQNLNSADLLKALCYPRVKVGNEYVTKGQTV 321
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  430 EQVTCAVGALSKSMYERMFKWLVARINRALDAKLSRQFFIGILDITGFEILEYNSLEQLCINFTNEKLQQFFNWHMFVLE 509
Cdd:cd14910   322 QQVYNAVGALAKAVYDKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLE 401
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  510 QEEYKKESIEWVSIGFGLDLQACIDLIEKPMGILSILEEECMFPKATDLTFKTKLFDNHFGKSVHLQKPKPDKKKFEAHF 589
Cdd:cd14910   402 QEEYKKEGIEWEFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYEQHLGKSNNFQKPKPAKGKVEAHF 481
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  590 ELVHYAGVVPYNISGWLEKNKDLLNETVVAVFQKSSNRLLASLFENYMSTDSAIPFGEK-KRKKGASFQTVASLHKENLN 668
Cdd:cd14910   482 SLIHYAGTVDYNIAGWLDKNKDPLNETVVGLYQKSSMKTLALLFSGAAAAEAEEGGGKKgGKKKGSSFQTVSALFRENLN 561
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  669 KLMTNLKSTAPHFVRCINPNVNKIPGILDPYLVLQQLRCNGVLEGTRICREGFPNRLQYADFKQRYCILNPRTFPKSKFV 748
Cdd:cd14910   562 KLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASAIPEGQFI 641
                         650       660       670
                  ....*....|....*....|....*....|
gi 767926067  749 SSRKAAEELLGSLEIDHTQYRFGITKVFFK 778
Cdd:cd14910   642 DSKKASEKLLGSIDIDHTQYKFGHTKVFFK 671
MYSc_Myh2_mammals cd14912
class II myosin heavy chain 2, motor domain; Myosin motor domain of type IIa skeletal muscle ...
118-778 0e+00

class II myosin heavy chain 2, motor domain; Myosin motor domain of type IIa skeletal muscle myosin heavy chain 2 (also called MYH2A, MYHSA2, MyHC-IIa, MYHas8, MyHC-2A) in mammals. Mutations in this gene results in inclusion body myopathy-3 and familial congenital myopathy. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276877 [Multi-domain]  Cd Length: 673  Bit Score: 927.99  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  118 SVLHTLKRRYGQWMIYTYSGLFCVTINPYKWLPVYQKEVMAAYKGKRRSEAPPHIFAVANNAFQDMLHNRENQSILFTGE 197
Cdd:cd14912     2 AVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVTAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGE 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  198 SGAGKTVNSKHIIQYFATIAAMIESRKK-------QGALEDQIMQANTILEAFGNAKTLRNDNSSRFGKFIRMHFGARGM 270
Cdd:cd14912    82 SGAGKTVNTKRVIQYFATIAVTGEKKKEeitsgkmQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGK 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  271 LSSVDIDIYLLEKSRVIFQQAGERNYHIFYQILSGQK-ELHDLLLVSANPSDFHFCSCGAVTVESLDDAEELLATEQAMD 349
Cdd:cd14912   162 LASADIETYLLEKSRVTFQLKAERSYHIFYQITSNKKpELIEMLLITTNPYDYPFVSQGEISVASIDDQEELMATDSAID 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  350 ILGFLPDEKYGCYKLTGAIMHFGNMKFKQKPREEQLEADGTENADKAAFLMGINSSELVKCLIHPRIKVGNEYVTRGQTI 429
Cdd:cd14912   242 ILGFTNEEKVSIYKLTGAVMHYGNLKFKQKQREEQAEPDGTEVADKAAYLQSLNSADLLKALCYPRVKVGNEYVTKGQTV 321
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  430 EQVTCAVGALSKSMYERMFKWLVARINRALDAKLSRQFFIGILDITGFEILEYNSLEQLCINFTNEKLQQFFNWHMFVLE 509
Cdd:cd14912   322 EQVTNAVGALAKAVYEKMFLWMVARINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLE 401
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  510 QEEYKKESIEWVSIGFGLDLQACIDLIEKPMGILSILEEECMFPKATDLTFKTKLFDNHFGKSVHLQKPKPDKKKFEAHF 589
Cdd:cd14912   402 QEEYKKEGIEWTFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYEQHLGKSANFQKPKVVKGKAEAHF 481
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  590 ELVHYAGVVPYNISGWLEKNKDLLNETVVAVFQKSSNRLLASLFENYMSTDSAIPFGEKK---RKKGASFQTVASLHKEN 666
Cdd:cd14912   482 SLIHYAGVVDYNITGWLDKNKDPLNETVVGLYQKSAMKTLAYLFSGAQTAEGASAGGGAKkggKKKGSSFQTVSALFREN 561
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  667 LNKLMTNLKSTAPHFVRCINPNVNKIPGILDPYLVLQQLRCNGVLEGTRICREGFPNRLQYADFKQRYCILNPRTFPKSK 746
Cdd:cd14912   562 LNKLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASAIPEGQ 641
                         650       660       670
                  ....*....|....*....|....*....|..
gi 767926067  747 FVSSRKAAEELLGSLEIDHTQYRFGITKVFFK 778
Cdd:cd14912   642 FIDSKKASEKLLASIDIDHTQYKFGHTKVFFK 673
MYSc_Myh16 cd14934
class II myosin heavy chain 16, motor domain; Myosin motor domain of myosin heavy chain 16 ...
117-778 0e+00

class II myosin heavy chain 16, motor domain; Myosin motor domain of myosin heavy chain 16 pseudogene (also called MHC20, MYH16, and myh5), encoding a sarcomeric myosin heavy chain expressed in nonhuman primate masticatory muscles, is inactivated in humans. This cd contains Myh16 in mammals. MYH16 has intermediate fibres between that of slow type 1 and fast 2B fibres, but exert more force than any other fibre type examined. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. Some of the data used for this classification were produced by the CyMoBase team at the Max-Planck-Institute for Biophysical Chemistry. The sequence names are composed of the species abbreviation followed by the protein abbreviation and optional protein classifier and variant designations.


Pssm-ID: 276896 [Multi-domain]  Cd Length: 659  Bit Score: 923.27  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  117 ASVLHTLKRRYGQWMIYTYSGLFCVTINPYKWLPVYQKEVMAAYKGKRRSEAPPHIFAVANNAFQDMLHNRENQSILFTG 196
Cdd:cd14934     1 ASVLDNLRQRYTNMRIYTYSGLFCVTVNPYKWLPIYGARVANMYKGKKRTEMPPHLFSISDNAYHDMLMDRENQSMLITG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  197 ESGAGKTVNSKHIIQYFATIAAM-IESRKKQGALEDQIMQANTILEAFGNAKTLRNDNSSRFGKFIRMHFGARGMLSSVD 275
Cdd:cd14934    81 ESGAGKTENTKKVIQYFANIGGTgKQSSDGKGSLEDQIIQANPVLEAFGNAKTTRNNNSSRFGKFIRIHFGTTGKLAGAD 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  276 IDIYLLEKSRVIFQQAGERNYHIFYQILSGQK-ELHDLLLVSANPSDFHFCSCGAVTVESLDDAEELLATEQAMDILGFL 354
Cdd:cd14934   161 IESYLLEKSRVISQQAAERGYHIFYQILSNKKpELIESLLLVPNPKEYHWVSQGVTVVDNMDDGEELQITDVAFDVLGFS 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  355 PDEKYGCYKLTGAIMHFGNMKFKQKPREEQLEADGTENADKAAFLMGINSSELVKCLIHPRIKVGNEYVTRGQTIEQVTC 434
Cdd:cd14934   241 AEEKIGVYKLTGGIMHFGNMKFKQKPREEQAEVDTTEVADKVAHLMGLNSGELQKGITRPRVKVGNEFVQKGQNMEQCNN 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  435 AVGALSKSMYERMFKWLVARINRALDAKLSRQFFIGILDITGFEILEYNSLEQLCINFTNEKLQQFFNWHMFVLEQEEYK 514
Cdd:cd14934   321 SIGALGKAVYDKMFKWLVVRINKTLDTKMQRQFFIGVLDIAGFEIFEFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYK 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  515 KESIEWVSIGFGLDLQACIDLIEKPMGILSILEEECMFPKATDLTFKTKLFDNHFGKSVHLQKPKPDK-KKFEAHFELVH 593
Cdd:cd14934   401 REGIEWVFIDFGLDLQACIDLLEKPMGIFSILEEQCVFPKATDATFKAALYDNHLGKSSNFLKPKGGKgKGPEAHFELVH 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  594 YAGVVPYNISGWLEKNKDLLNETVVAVFQKSSNRLLASLFEnymstDSAIPFGEKKRKKGASFQTVASLHKENLNKLMTN 673
Cdd:cd14934   481 YAGTVGYNITGWLEKNKDPLNETVVGLFQKSSLGLLALLFK-----EEEAPAGSKKQKRGSSFMTVSNFYREQLNKLMTT 555
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  674 LKSTAPHFVRCINPNVNKIPGILDPYLVLQQLRCNGVLEGTRICREGFPNRLQYADFKQRYCILNPRTFPKSkFVSSRKA 753
Cdd:cd14934   556 LHSTAPHFVRCIVPNEFKQSGVVDAHLIMHQLACNGVLEGIRICRKGFPNRLQYPEFKQRYQVLNPNVIPQG-FVDNKKA 634
                         650       660
                  ....*....|....*....|....*
gi 767926067  754 AEELLGSLEIDHTQYRFGITKVFFK 778
Cdd:cd14934   635 SELLLGSIDLDVNEYKIGHTKVFFR 659
MYSc_Myh1_insects_crustaceans cd14909
class II myosin heavy chain 1, motor domain; Myosin motor domain of type IIx skeletal muscle ...
117-778 0e+00

class II myosin heavy chain 1, motor domain; Myosin motor domain of type IIx skeletal muscle myosin heavy chain 1 (also called MYHSA1, MYHa, MyHC-2X/D, MGC133384) in insects and crustaceans. Myh1 is a type I skeletal muscle myosin that in Humans is encoded by the MYH1 gene. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276874  Cd Length: 666  Bit Score: 908.83  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  117 ASVLHTLKRRYGQWMIYTYSGLFCVTINPYKWLPVYQKEVMAAYKGKRRSEAPPHIFAVANNAFQDMLHNRENQSILFTG 196
Cdd:cd14909     1 ASVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  197 ESGAGKTVNSKHIIQYFATIAAMI---ESRKKQGALEDQIMQANTILEAFGNAKTLRNDNSSRFGKFIRMHFGARGMLSS 273
Cdd:cd14909    81 ESGAGKTENTKKVIAYFATVGASKktdEAAKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAG 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  274 VDIDIYLLEKSRVIFQQAGERNYHIFYQILSGQ-KELHDLLLVSANPSDFHFCSCGAVTVESLDDAEELLATEQAMDILG 352
Cdd:cd14909   161 ADIETYLLEKARVISQQSLERSYHIFYQIMSGSvPGVKEMCLLSDNIYDYYIVSQGKVTVPNVDDGEEFSLTDQAFDILG 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  353 FLPDEKYGCYKLTGAIMHFGNMKFKQKPREEQLEADGTENADKAAFLMGINSSELVKCLIHPRIKVGNEYVTRGQTIEQV 432
Cdd:cd14909   241 FTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKNLLKPRIKVGNEFVTQGRNVQQV 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  433 TCAVGALSKSMYERMFKWLVARINRALDAKLSRQFFIGILDITGFEILEYNSLEQLCINFTNEKLQQFFNWHMFVLEQEE 512
Cdd:cd14909   321 TNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFEIFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEE 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  513 YKKESIEWVSIGFGLDLQACIDLIEKPMGILSILEEECMFPKATDLTFKTKLFDNHFGKSVHLQKPKPDKKKFEA-HFEL 591
Cdd:cd14909   401 YKREGIDWAFIDFGMDLLACIDLIEKPMGILSILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAaHFAI 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  592 VHYAGVVPYNISGWLEKNKDLLNETVVAVFQKSSNRLLASLFENYmSTDSAIPFGEK--KRKKGASFQTVASLHKENLNK 669
Cdd:cd14909   481 AHYAGCVSYNITGWLEKNKDPLNDTVVDQFKKSQNKLLIEIFADH-AGQSGGGEQAKggRGKKGGGFATVSSAYKEQLNS 559
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  670 LMTNLKSTAPHFVRCINPNVNKIPGILDPYLVLQQLRCNGVLEGTRICREGFPNRLQYADFKQRYCILNPRTFPKSKfvS 749
Cdd:cd14909   560 LMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKILNPAGIQGEE--D 637
                         650       660
                  ....*....|....*....|....*....
gi 767926067  750 SRKAAEELLGSLEIDHTQYRFGITKVFFK 778
Cdd:cd14909   638 PKKAAEIILESIALDPDQYRLGHTKVFFR 666
COG5022 COG5022
Myosin heavy chain [General function prediction only];
53-1460 0e+00

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 817.39  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   53 KCWIPDGENAYIEAEVKGSEDDGTVIVETAD---GESLSIKEDKIQQ--MNPPEFEMIEDMAMLTHLNEASVLHTLKRRY 127
Cdd:COG5022    11 GCWIPDEEKGWIWAEIIKEAFNKGKVTEEGKkedGESVSVKKKVLGNdrIKLPKFDGVDDLTELSYLNEPAVLHNLEKRY 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  128 GQWMIYTYSGLFCVTINPYKWLPVYQKEVMAAYKGKRRSEAPPHIFAVANNAFQDMLHNRENQSILFTGESGAGKTVNSK 207
Cdd:COG5022    91 NNGQIYTYSGLVLIAVNPYRDLGIYTDDIIQSYSGKNRLELEPHVFAIAEEAYRNLLSEKENQTIIISGESGAGKTENAK 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  208 HIIQYFATIAAMIESRKKQgaLEDQIMQANTILEAFGNAKTLRNDNSSRFGKFIRMHFGARGMLSSVDIDIYLLEKSRVI 287
Cdd:COG5022   171 RIMQYLASVTSSSTVEISS--IEKQILATNPILEAFGNAKTVRNDNSSRFGKYIKIEFDENGEICGAKIETYLLEKSRVV 248
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  288 FQQAGERNYHIFYQILSGQKELHDLLLVSANPSDFHFCSCGAVT-VESLDDAEELLATEQAMDILGFLPDEKYGCYKLTG 366
Cdd:COG5022   249 HQNKNERNYHIFYQLLAGDPEELKKLLLLQNPKDYIYLSQGGCDkIDGIDDAKEFKITLDALKTIGIDEEEQDQIFKILA 328
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  367 AIMHFGNMKFKqKPREEQLEADGTENADKAAFLMGINSSELVKCLIHPRIKVGNEYVTRGQTIEQVTCAVGALSKSMYER 446
Cdd:COG5022   329 AILHIGNIEFK-EDRNGAAIFSDNSVLDKACYLLGIDPSLFVKWLVKRQIKTGGEWIVVPLNLEQALAIRDSLAKALYSN 407
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  447 MFKWLVARINRALDAKLSRQFFIGILDITGFEILEYNSLEQLCINFTNEKLQQFFNWHMFVLEQEEYKKESIEWVSIGFg 526
Cdd:COG5022   408 LFDWIVDRINKSLDHSAAASNFIGVLDIYGFEIFEKNSFEQLCINYTNEKLQQFFNQHMFKLEQEEYVKEGIEWSFIDY- 486
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  527 LDLQACIDLIEK--PMGILSILEEECMFPKATDLTFKTKLFDN-HFGKSVHLQKPKPDKKKfeahFELVHYAGVVPYNIS 603
Cdd:COG5022   487 FDNQPCIDLIEKknPLGILSLLDEECVMPHATDESFTSKLAQRlNKNSNPKFKKSRFRDNK----FVVKHYAGDVEYDVE 562
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  604 GWLEKNKDLLNETVVAVFQKSSNRLLASLFENYMSTdsaipfgEKKRKkgasFQTVASLHKENLNKLMTNLKSTAPHFVR 683
Cdd:COG5022   563 GFLDKNKDPLNDDLLELLKASTNEFVSTLFDDEENI-------ESKGR----FPTLGSRFKESLNSLMSTLNSTQPHYIR 631
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  684 CINPNVNKIPGILDPYLVLQQLRCNGVLEGTRICREGFPNRLQYADFKQRYCILNP---RTFPKSKFVSSRKAAEELLGS 760
Cdd:COG5022   632 CIKPNEEKSPWTFDNQMVLSQLRCCGVLETIRISRAGFPSRWTFDEFVQRYRILSPsksWTGEYTWKEDTKNAVKSILEE 711
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  761 LEIDHTQYRFGITKVFFKAGFLGQLEAIRDERLSKVFTLFQARAQGKLMRIKFQKILEERDALILIQWNIRAFMAVKNWP 840
Cdd:COG5022   712 LVIDSSKYQIGNTKVFFKAGVLAALEDMRDAKLDNIATRIQRAIRGRYLRRRYLQALKRIKKIQVIQHGFRLRRLVDYEL 791
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  841 WMRLFFKIKPLVKSSEVGEEVaGLKEECAQlqkaleksEFQREELKAKQVSLTQEKNDLIlqlqaeqetlanveeQCEWL 920
Cdd:COG5022   792 KWRLFIKLQPLLSLLGSRKEY-RSYLACII--------KLQKTIKREKKLRETEEVEFSL---------------KAEVL 847
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  921 IKSKIQLEARVKELSERVEEEEEINSelTARGRKLEDECFELKKEIDDLETM-LVKSEKEKRTTEHK---VKNLTEEVEF 996
Cdd:COG5022   848 IQKFGRSLKAKKRFSLLKKETIYLQS--AQRVELAERQLQELKIDVKSISSLkLVNLELESEIIELKkslSSDLIENLEF 925
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  997 LNEDISKL-----NRAAKVVQEAHQQTLDDLHMEEEKLSSLSKANLKLEQQVDELEGALEQERKARMNCER---ELHKLE 1068
Cdd:COG5022   926 KTELIARLkkllnNIDLEEGPSIEYVKLPELNKLHEVESKLKETSEEYEDLLKKSTILVREGNKANSELKNfkkELAELS 1005
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1069 GNLKLNRESMENLESSQRHLAeELRKKELELSQMNSKVENEKGlvaqLQKTVKELQTQIKDLKEKLEAerttrAKMERER 1148
Cdd:COG5022  1006 KQYGALQESTKQLKELPVEVA-ELQSASKIISSESTELSILKP----LQKLKGLLLLENNQLQARYKA-----LKLRREN 1075
                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1149 adltQDLADLNERLEEVGGSSLAQLEITKKQETKFQKLHRDMEEATLHFETTSASLKKRHADSLAELegqVENLQQVKQK 1228
Cdd:COG5022  1076 ----SLLDDKQLYQLESTENLLKTINVKDLEVTNRNLVKPANVLQFIVAQMIKLNLLQEISKFLSQL---VNTLEPVFQK 1148
                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1229 LEKDksdlQLEVDDLLTrvEQMTRAKANAEKLCTLYEERLHEA-------TAKLDKVTQLANDLAAQKTKLWSES--GEF 1299
Cdd:COG5022  1149 LSVL----QLELDGLFW--EANLEALPSPPPFAALSEKRLYQSalydeksKLSSSEVNDLKNELIALFSKIFSGWprGDK 1222
                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1300 LRRLEEKEALINQLSR--EKSNFTRQIEDLRGQLEKEtksqsALAHALQKAQRDCDLLREQYEEE--------QEVKAEL 1369
Cdd:COG5022  1223 LKKLISEGWVPTEYSTslKGFNNLNKKFDTPASMSNE-----KLLSLLNSIDNLLSSYKLEEEVLpatinsllQYINVGL 1297
                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1370 HRTLSKVNAEMvqwRMKYENNVIQRTEDLEDAKKELAI-RLQEAAEamgvanarnaSLERARHQLQLELGDaLSDLGKVR 1448
Cdd:COG5022  1298 FNALRTKASSL---RWKSATEVNYNSEELDDWCREFEIsDVDEELE----------ELIQAVKVLQLLKDD-LNKLDELL 1363
                        1450
                  ....*....|..
gi 767926067 1449 SAAARLDQKQLQ 1460
Cdd:COG5022  1364 DACYSLNPAEIQ 1375
MYSc cd00124
Myosin motor domain superfamily; Myosin motor domain. The catalytic (head) domain has ATPase ...
117-778 0e+00

Myosin motor domain superfamily; Myosin motor domain. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276950 [Multi-domain]  Cd Length: 633  Bit Score: 786.78  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  117 ASVLHTLKRRYGQWMIYTYSGLFCVTINPYKWLPVYQKEVMAAYKGKRR-SEAPPHIFAVANNAFQDMLHNRENQSILFT 195
Cdd:cd00124     1 AAILHNLRERYARDLIYTYVGDILVAVNPFKWLPLYSEEVMEKYRGKGRsADLPPHVFAVADAAYRAMLRDGQNQSILIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  196 GESGAGKTVNSKHIIQYFATIAA--MIESRKKQGALEDQIMQANTILEAFGNAKTLRNDNSSRFGKFIRMHFGARGMLSS 273
Cdd:cd00124    81 GESGAGKTETTKLVLKYLAALSGsgSSKSSSSASSIEQQILQSNPILEAFGNAKTVRNDNSSRFGKFIELQFDPTGRLVG 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  274 VDIDIYLLEKSRVIFQQAGERNYHIFYQILSGQ-----KELHDLLLVSANPSDFHFCSCGAVTVESLDDAEELLATEQAM 348
Cdd:cd00124   161 ASIETYLLEKSRVVSQAPGERNFHIFYQLLAGLsdgarEELKLELLLSYYYLNDYLNSSGCDRIDGVDDAEEFQELLDAL 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  349 DILGFLPDEKYGCYKLTGAIMHFGNMKFKQKPREE--QLEADGTENADKAAFLMGINSSELVKCLIHPRIKVGNEYVTRG 426
Cdd:cd00124   241 DVLGFSDEEQDSIFRILAAILHLGNIEFEEDEEDEdsSAEVADDESLKAAAKLLGVDAEDLEEALTTRTIKVGGETITKP 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  427 QTIEQVTCAVGALSKSMYERMFKWLVARINRALDAKLSRQF--FIGILDITGFEILEYNSLEQLCINFTNEKLQQFFNWH 504
Cdd:cd00124   321 LTVEQAEDARDALAKALYSRLFDWLVNRINAALSPTDAAEStsFIGILDIFGFENFEVNSFEQLCINYANEKLQQFFNQH 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  505 MFVLEQEEYKKESIEWVSIGFgLDLQACIDLIE-KPMGILSILEEECMFPKATDLTFKTKLFDNHFGKSVHLQKPKPDKK 583
Cdd:cd00124   401 VFKLEQEEYEEEGIDWSFIDF-PDNQDCLDLIEgKPLGILSLLDEECLFPKGTDATFLEKLYSAHGSHPRFFSKKRKAKL 479
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  584 kfeaHFELVHYAGVVPYNISGWLEKNKDLLNETVVAVFQKSsnrllaslfenymstdsaipfgekkrkkgasfqtvaSLH 663
Cdd:cd00124   480 ----EFGIKHYAGDVTYDADGFLEKNKDTLPPDLVDLLRSG------------------------------------SQF 519
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  664 KENLNKLMTNLKSTAPHFVRCINPNVNKIPGILDPYLVLQQLRCNGVLEGTRICREGFPNRLQYADFKQRYCILNPRtFP 743
Cdd:cd00124   520 RSQLDALMDTLNSTQPHFVRCIKPNDEKKPGLFDPELVLEQLRCAGVLEAVRIRRAGYPVRLPFDEFLKRYRILAPG-AT 598
                         650       660       670
                  ....*....|....*....|....*....|....*
gi 767926067  744 KSKFVSSRKAAEELLGSLEIDHTQYRFGITKVFFK 778
Cdd:cd00124   599 EKASDSKKAAVLALLLLLKLDSSGYQLGKTKVFLR 633
MYSc_Myh2_insects_mollusks cd14911
class II myosin heavy chain 2, motor domain; Myosin motor domain of type IIa skeletal muscle ...
117-778 0e+00

class II myosin heavy chain 2, motor domain; Myosin motor domain of type IIa skeletal muscle myosin heavy chain 2 (also called MYH2A, MYHSA2, MyHC-IIa, MYHas8, MyHC-2A) in insects and mollusks. This gene encodes a member of the class II or conventional myosin heavy chains, and functions in skeletal muscle contraction. Mutations in this gene results in inclusion body myopathy-3 and familial congenital myopathy. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276876 [Multi-domain]  Cd Length: 674  Bit Score: 737.18  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  117 ASVLHTLKRRYGQWMIYTYSGLFCVTINPYKWLPVYQKEVMAAYKGKRRSEAPPHIFAVANNAFQDMLHNRENQSILFTG 196
Cdd:cd14911     1 ASVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLPIYTEKIMERYKGIKRHEVPPHVFAITDSAYRNMLGDREDQSILCTG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  197 ESGAGKTVNSKHIIQYFATIAA------------MIESRKKQGALEDQIMQANTILEAFGNAKTLRNDNSSRFGKFIRMH 264
Cdd:cd14911    81 ESGAGKTENTKKVIQFLAYVAAskpkgsgavphpAVNPAVLIGELEQQLLQANPILEAFGNAKTVKNDNSSRFGKFIRIN 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  265 FGARGMLSSVDIDIYLLEKSRVIFQQAGERNYHIFYQILSGQKELHDLLLVSANPSDFHFCSCGAVTVESLDDAEELLAT 344
Cdd:cd14911   161 FDASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLLAGATPEQREKFILDDVKSYAFLSNGSLPVPGVDDYAEFQAT 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  345 EQAMDILGFLPDEKYGCYKLTGAIMHFGNMKFKQKPREEQLEADGTENADKAAFLMGINSSELVKCLIHPRIKVGNEYVT 424
Cdd:cd14911   241 VKSMNIMGMTSEDFNSIFRIVSAVLLFGSMKFRQERNNDQATLPDNTVAQKIAHLLGLSVTDMTRAFLTPRIKVGRDFVT 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  425 RGQTIEQVTCAVGALSKSMYERMFKWLVARINRALDaKLSRQ--FFIGILDITGFEILEYNSLEQLCINFTNEKLQQFFN 502
Cdd:cd14911   321 KAQTKEQVEFAVEAIAKACYERMFKWLVNRINRSLD-RTKRQgaSFIGILDMAGFEIFELNSFEQLCINYTNEKLQQLFN 399
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  503 WHMFVLEQEEYKKESIEWVSIGFGLDLQACIDLIEKPMGILSILEEECMFPKATDLTFKTKLFDNHfgkSVHlqkPKPDK 582
Cdd:cd14911   400 HTMFILEQEEYQREGIEWKFIDFGLDLQPTIDLIDKPGGIMALLDEECWFPKATDKTFVDKLVSAH---SMH---PKFMK 473
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  583 KKFE--AHFELVHYAGVVPYNISGWLEKNKDLLNETVVAVFQKSSNRLLASLFENYMSTDSA------IPFGEKKRKkgA 654
Cdd:cd14911   474 TDFRgvADFAIVHYAGRVDYSAAKWLMKNMDPLNENIVSLLQGSQDPFVVNIWKDAEIVGMAqqaltdTQFGARTRK--G 551
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  655 SFQTVASLHKENLNKLMTNLKSTAPHFVRCINPNVNKIPGILDPYLVLQQLRCNGVLEGTRICREGFPNRLQYADFKQRY 734
Cdd:cd14911   552 MFRTVSHLYKEQLAKLMDTLRNTNPNFVRCIIPNHEKRAGKIDAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQRY 631
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|....
gi 767926067  735 CILNPRTFPKSkFVSSRKAAEELLGSLEIDHTQYRFGITKVFFK 778
Cdd:cd14911   632 ELLTPNVIPKG-FMDGKKACEKMIQALELDSNLYRVGQSKIFFR 674
MYSc_Myh10 cd14920
class II myosin heavy chain 10, motor domain; Myosin motor domain of non-muscle myosin heavy ...
117-778 0e+00

class II myosin heavy chain 10, motor domain; Myosin motor domain of non-muscle myosin heavy chain 10 (also called NMMHCB). Mutations in this gene have been associated with May-Hegglin anomaly and developmental defects in brain and heart. Multiple transcript variants encoding different isoforms have been found for this gene. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276952 [Multi-domain]  Cd Length: 673  Bit Score: 725.65  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  117 ASVLHTLKRRYGQWMIYTYSGLFCVTINPYKWLPVYQKEVMAAYKGKRRSEAPPHIFAVANNAFQDMLHNRENQSILFTG 196
Cdd:cd14920     1 ASVLHNLKDRYYSGLIYTYSGLFCVVINPYKNLPIYSENIIEMYRGKKRHEMPPHIYAISESAYRCMLQDREDQSILCTG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  197 ESGAGKTVNSKHIIQYFATIAAMIESRKK---QGALEDQIMQANTILEAFGNAKTLRNDNSSRFGKFIRMHFGARGMLSS 273
Cdd:cd14920    81 ESGAGKTENTKKVIQYLAHVASSHKGRKDhniPGELERQLLQANPILESFGNAKTVKNDNSSRFGKFIRINFDVTGYIVG 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  274 VDIDIYLLEKSRVIFQQAGERNYHIFYQILSGQKE--LHDLLLVSANpsDFHFCSCGAVTVESLDDAEELLATEQAMDIL 351
Cdd:cd14920   161 ANIETYLLEKSRAVRQAKDERTFHIFYQLLSGAGEhlKSDLLLEGFN--NYRFLSNGYIPIPGQQDKDNFQETMEAMHIM 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  352 GFLPDEKYGCYKLTGAIMHFGNMKFKQKPREEQLEADGTENADKAAFLMGINSSELVKCLIHPRIKVGNEYVTRGQTIEQ 431
Cdd:cd14920   239 GFSHEEILSMLKVVSSVLQFGNISFKKERNTDQASMPENTVAQKLCHLLGMNVMEFTRAILTPRIKVGRDYVQKAQTKEQ 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  432 VTCAVGALSKSMYERMFKWLVARINRALDaKLSRQ--FFIGILDITGFEILEYNSLEQLCINFTNEKLQQFFNWHMFVLE 509
Cdd:cd14920   319 ADFAVEALAKATYERLFRWLVHRINKALD-RTKRQgaSFIGILDIAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFILE 397
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  510 QEEYKKESIEWVSIGFGLDLQACIDLIEKPM---GILSILEEECMFPKATDLTFKTKLFDNHfGKSVHLQKPKpdKKKFE 586
Cdd:cd14920   398 QEEYQREGIEWNFIDFGLDLQPCIDLIERPAnppGVLALLDEECWFPKATDKTFVEKLVQEQ-GSHSKFQKPR--QLKDK 474
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  587 AHFELVHYAGVVPYNISGWLEKNKDLLNETVVAVFQKSSNRLLASLFENY-----MSTDSAIP---FGEKKRKKGASFQT 658
Cdd:cd14920   475 ADFCIIHYAGKVDYKADEWLMKNMDPLNDNVATLLHQSSDRFVAELWKDVdrivgLDQVTGMTetaFGSAYKTKKGMFRT 554
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  659 VASLHKENLNKLMTNLKSTAPHFVRCINPNVNKIPGILDPYLVLQQLRCNGVLEGTRICREGFPNRLQYADFKQRYCILN 738
Cdd:cd14920   555 VGQLYKESLTKLMATLRNTNPNFVRCIIPNHEKRAGKLDPHLVLDQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEILT 634
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|
gi 767926067  739 PRTFPKSkFVSSRKAAEELLGSLEIDHTQYRFGITKVFFK 778
Cdd:cd14920   635 PNAIPKG-FMDGKQACERMIRALELDPNLYRIGQSKIFFR 673
MYSc_Myo5 cd01380
class V myosin, motor domain; Myo5, also called heavy chain 12, myoxin, are dimeric myosins ...
118-778 0e+00

class V myosin, motor domain; Myo5, also called heavy chain 12, myoxin, are dimeric myosins that transport a variety of intracellular cargo processively along actin filaments, such as melanosomes, synaptic vesicles, vacuoles, and mRNA. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. It also contains a IQ domain and a globular DIL domain. Myosin V is a class of actin-based motor proteins involved in cytoplasmic vesicle transport and anchorage, spindle-pole alignment and mRNA translocation. The protein encoded by this gene is abundant in melanocytes and nerve cells. Mutations in this gene cause Griscelli syndrome type-1 (GS1), Griscelli syndrome type-3 (GS3) and neuroectodermal melanolysosomal disease, or Elejalde disease. Multiple alternatively spliced transcript variants encoding different isoforms have been reported, but the full-length nature of some variants has not been determined. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. Note that the Dictyostelium myoVs are not contained in this child group. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276831 [Multi-domain]  Cd Length: 629  Bit Score: 673.10  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  118 SVLHTLKRRYGQW-MIYTYSGLFCVTINPYKWLPVYQKEVMAAYKGKRRSEAPPHIFAVANNAFQDMLHNRENQSILFTG 196
Cdd:cd01380     2 AVLHNLKVRFCQRnAIYTYCGIVLVAINPYEDLPIYGEDIIQAYSGQNMGELDPHIFAIAEEAYRQMARDEKNQSIIVSG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  197 ESGAGKTVNSKHIIQYFATIAAmieSRKKQGALEDQIMQANTILEAFGNAKTLRNDNSSRFGKFIRMHFGARGMLSSVDI 276
Cdd:cd01380    82 ESGAGKTVSAKYAMRYFATVGG---SSSGETQVEEKVLASNPIMEAFGNAKTTRNDNSSRFGKYIEILFDKNYRIIGANM 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  277 DIYLLEKSRVIFQQAGERNYHIFYQILSG--QKELHDLLLVSANpSDFHFCSCGAVTVESLDDAEELLATEQAMDILGFL 354
Cdd:cd01380   159 RTYLLEKSRVVFQAEEERNYHIFYQLCAAasLPELKELHLGSAE-DFFYTNQGGSPVIDGVDDAAEFEETRKALTLLGIS 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  355 PDEKYGCYKLTGAIMHFGNMKFKQKPREEQLEADGTENADKAAFLMGINSSELVKCLIHPRIKVGNEYVTRGQTIEQVTC 434
Cdd:cd01380   238 EEEQMEIFRILAAILHLGNVEIKATRNDSASISPDDEHLQIACELLGIDESQLAKWLCKRKIVTRSEVIVKPLTLQQAIV 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  435 AVGALSKSMYERMFKWLVARINRALDAKLSRQF--FIGILDITGFEILEYNSLEQLCINFTNEKLQQFFNWHMFVLEQEE 512
Cdd:cd01380   318 ARDALAKHIYAQLFDWIVDRINKALASPVKEKQhsFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEE 397
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  513 YKKESIEWVSIGFgLDLQACIDLIEKPMGILSILEEECMFPKATDLTFKTKLFDNHFGKSV-HLQKPKPDKKKfeahFEL 591
Cdd:cd01380   398 YVKEEIEWSFIDF-YDNQPCIDLIEGKLGILDLLDEECRLPKGSDENWAQKLYNQHLKKPNkHFKKPRFSNTA----FIV 472
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  592 VHYAGVVPYNISGWLEKNKDLLNETVVAVFQKSSNRllaslfenymstdsaipfgeKKrkkgasfqTVASLHKENLNKLM 671
Cdd:cd01380   473 KHFADDVEYQVEGFLEKNRDTVSEEHLNVLKASKNR--------------------KK--------TVGSQFRDSLILLM 524
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  672 TNLKSTAPHFVRCINPNVNKIPGILDPYLVLQQLRCNGVLEGTRICREGFPNRLQYADFKQRYCILNPRTFPKSKfvSSR 751
Cdd:cd01380   525 ETLNSTTPHYVRCIKPNDEKLPFTFDPKRVVQQLRACGVLETIRISAAGFPSRWTYEEFFSRYRVLLPSKEWLRD--DKK 602
                         650       660
                  ....*....|....*....|....*..
gi 767926067  752 KAAEELLGSLEIDHTQYRFGITKVFFK 778
Cdd:cd01380   603 KTCENILENLILDPDKYQFGKTKIFFR 629
MYSc_Myh18 cd14932
class II myosin heavy chain 18, motor domain; Myosin motor domain of muscle myosin heavy chain ...
117-778 0e+00

class II myosin heavy chain 18, motor domain; Myosin motor domain of muscle myosin heavy chain 18. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276895 [Multi-domain]  Cd Length: 676  Bit Score: 670.20  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  117 ASVLHTLKRRYGQWMIYTYSGLFCVTINPYKWLPVYQKEVMAAYKGKRRSEAPPHIFAVANNAFQDMLHNRENQSILFTG 196
Cdd:cd14932     1 ASVLHNLKERYYSGLIYTYSGLFCVVINPYKYLPIYSEEIVNMYKGKKRHEMPPHIYAITDTAYRSMMQDREDQSILCTG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  197 ESGAGKTVNSKHIIQYFATIAAMIESRKKQGA-------LEDQIMQANTILEAFGNAKTLRNDNSSRFGKFIRMHFGARG 269
Cdd:cd14932    81 ESGAGKTENTKKVIQYLAYVASSFKTKKDQSSialshgeLEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVNG 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  270 MLSSVDIDIYLLEKSRVIFQQAGERNYHIFYQILSGQKELHDLLLVSANPSDFHFCSCGAVTVESLDDAEELLATEQAMD 349
Cdd:cd14932   161 YIVGANIETYLLEKSRAIRQAKDERAFHIFYYLLTGAGDKLRSELCLEDYSKYRFLSNGNVTIPGQQDKELFAETMEAFR 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  350 ILGFLPDEKYGCYKLTGAIMHFGNMKFKQKPREEQLEADGTENADKAAFLMGINSSELVKCLIHPRIKVGNEYVTRGQTI 429
Cdd:cd14932   241 IMSIPEEEQTGLLKVVSAVLQLGNMSFKKERNSDQASMPDDTAAQKVCHLLGMNVTDFTRAILSPRIKVGRDYVQKAQTQ 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  430 EQVTCAVGALSKSMYERMFKWLVARINRALDaKLSRQ--FFIGILDITGFEILEYNSLEQLCINFTNEKLQQFFNWHMFV 507
Cdd:cd14932   321 EQAEFAVEALAKASYERMFRWLVMRINKALD-KTKRQgaSFIGILDIAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFI 399
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  508 LEQEEYKKESIEWVSIGFGLDLQACIDLIEKPM---GILSILEEECMFPKATDLTFKTKLFDNHfGKSVHLQKPKpdKKK 584
Cdd:cd14932   400 LEQEEYQREGIEWSFIDFGLDLQPCIELIEKPNgppGILALLDEECWFPKATDKSFVEKVVQEQ-GNNPKFQKPK--KLK 476
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  585 FEAHFELVHYAGVVPYNISGWLEKNKDLLNETVVAVFQKSSNRLLASLFENY--------MSTDSAIPFGEKKRKKGAsF 656
Cdd:cd14932   477 DDADFCIIHYAGKVDYKANEWLMKNMDPLNENVATLLNQSTDKFVSELWKDVdrivgldkVAGMGESLHGAFKTRKGM-F 555
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  657 QTVASLHKENLNKLMTNLKSTAPHFVRCINPNVNKIPGILDPYLVLQQLRCNGVLEGTRICREGFPNRLQYADFKQRYCI 736
Cdd:cd14932   556 RTVGQLYKEQLMNLMTTLRNTNPNFVRCIIPNHEKKAGKLAHHLVLDQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEI 635
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|..
gi 767926067  737 LNPRTFPKSkFVSSRKAAEELLGSLEIDHTQYRFGITKVFFK 778
Cdd:cd14932   636 LTPNAIPKG-FMDGKQACVLMVKALELDPNLYRIGQSKVFFR 676
MYSc_Myh11 cd14921
class II myosin heavy chain 11, motor domain; Myosin motor domain of smooth muscle myosin ...
117-778 0e+00

class II myosin heavy chain 11, motor domain; Myosin motor domain of smooth muscle myosin heavy chain 11 (also called SMMHC, SMHC). The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. The gene encoding a human ortholog of rat NUDE1 is transcribed from the reverse strand of this gene, and its 3' end overlaps with that of the latter. Inversion of the MYH11 locus is one of the most frequent chromosomal aberrations found in acute myeloid leukemia. Alternative splicing generates isoforms that are differentially expressed, with ratios changing during muscle cell maturation. Mutations in MYH11 have been described in individuals with thoracic aortic aneurysms leading to acute aortic dissections with patent ductus arteriosus. MYH11 mutations are also thought to contribute to human colorectal cancer and are also associated with Peutz-Jeghers syndrome. The mutations found in human intestinal neoplasia result in unregulated proteins with constitutive motor activity, similar to the mutant myh11 zebrafish. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276885 [Multi-domain]  Cd Length: 673  Bit Score: 649.00  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  117 ASVLHTLKRRYGQWMIYTYSGLFCVTINPYKWLPVYQKEVMAAYKGKRRSEAPPHIFAVANNAFQDMLHNRENQSILFTG 196
Cdd:cd14921     1 ASVLHNLRERYFSGLIYTYSGLFCVVVNPYKHLPIYSEKIVDMYKGKKRHEMPPHIYAIADTAYRSMLQDREDQSILCTG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  197 ESGAGKTVNSKHIIQYFATIAAMIESRKKQ---GALEDQIMQANTILEAFGNAKTLRNDNSSRFGKFIRMHFGARGMLSS 273
Cdd:cd14921    81 ESGAGKTENTKKVIQYLAVVASSHKGKKDTsitGELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVTGYIVG 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  274 VDIDIYLLEKSRVIFQQAGERNYHIFYQILSGQKEL--HDLLLVSANpsDFHFCSCGAVTVESLDDAEELLATEQAMDIL 351
Cdd:cd14921   161 ANIETYLLEKSRAIRQARDERTFHIFYYLIAGAKEKmrSDLLLEGFN--NYTFLSNGFVPIPAAQDDEMFQETLEAMSIM 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  352 GFLPDEKYGCYKLTGAIMHFGNMKFKQKPREEQLEADGTENADKAAFLMGINSSELVKCLIHPRIKVGNEYVTRGQTIEQ 431
Cdd:cd14921   239 GFSEEEQLSILKVVSSVLQLGNIVFKKERNTDQASMPDNTAAQKVCHLMGINVTDFTRSILTPRIKVGRDVVQKAQTKEQ 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  432 VTCAVGALSKSMYERMFKWLVARINRALDaKLSRQ--FFIGILDITGFEILEYNSLEQLCINFTNEKLQQFFNWHMFVLE 509
Cdd:cd14921   319 ADFAIEALAKATYERLFRWILTRVNKALD-KTHRQgaSFLGILDIAGFEIFEVNSFEQLCINYTNEKLQQLFNHTMFILE 397
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  510 QEEYKKESIEWVSIGFGLDLQACIDLIEKPM---GILSILEEECMFPKATDLTFKTKLFDNHfGKSVHLQKPKPDKKKFE 586
Cdd:cd14921   398 QEEYQREGIEWNFIDFGLDLQPCIELIERPNnppGVLALLDEECWFPKATDKSFVEKLCTEQ-GNHPKFQKPKQLKDKTE 476
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  587 ahFELVHYAGVVPYNISGWLEKNKDLLNETVVAVFQKSSNRLLASLFENY----------MSTDSAIPFGEKKRKkgASF 656
Cdd:cd14921   477 --FSIIHYAGKVDYNASAWLTKNMDPLNDNVTSLLNASSDKFVADLWKDVdrivgldqmaKMTESSLPSASKTKK--GMF 552
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  657 QTVASLHKENLNKLMTNLKSTAPHFVRCINPNVNKIPGILDPYLVLQQLRCNGVLEGTRICREGFPNRLQYADFKQRYCI 736
Cdd:cd14921   553 RTVGQLYKEQLGKLMTTLRNTTPNFVRCIIPNHEKRSGKLDAFLVLEQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEI 632
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|..
gi 767926067  737 LNPRTFPKSkFVSSRKAAEELLGSLEIDHTQYRFGITKVFFK 778
Cdd:cd14921   633 LAANAIPKG-FMDGKQACILMIKALELDPNLYRIGQSKIFFR 673
MYSc_Myh9 cd14919
class II myosin heavy chain 9, motor domain; Myosin motor domain of non-muscle myosin heavy ...
117-778 0e+00

class II myosin heavy chain 9, motor domain; Myosin motor domain of non-muscle myosin heavy chain 9 (also called NMMHCA, NMHC-II-A, MHA, FTNS, EPSTS, and DFNA17). Myosin is a hexameric protein composed of a pair of myosin heavy chains (MYH) and two pairs of nonidentical light chains. The encoded protein is a myosin IIA heavy chain that contains an IQ domain and a myosin head-like domain which is involved in several important functions, including cytokinesis, cell motility and maintenance of cell shape. Defects in this gene have been associated with non-syndromic sensorineural deafness autosomal dominant type 17, Epstein syndrome, Alport syndrome with macrothrombocytopenia, Sebastian syndrome, Fechtner syndrome and macrothrombocytopenia with progressive sensorineural deafness. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276883 [Multi-domain]  Cd Length: 670  Bit Score: 644.07  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  117 ASVLHTLKRRYGQWMIYTYSGLFCVTINPYKWLPVYQKEVMAAYKGKRRSEAPPHIFAVANNAFQDMLHNRENQSILFTG 196
Cdd:cd14919     1 ASVLHNLKERYYSGLIYTYSGLFCVVINPYKNLPIYSEEIVEMYKGKKRHEMPPHIYAITDTAYRSMMQDREDQSILCTG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  197 ESGAGKTVNSKHIIQYFATIAAMIESRKKQGALEDQIMQANTILEAFGNAKTLRNDNSSRFGKFIRMHFGARGMLSSVDI 276
Cdd:cd14919    81 ESGAGKTENTKKVIQYLAHVASSHKSKKDQGELERQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVNGYIVGANI 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  277 DIYLLEKSRVIFQQAGERNYHIFYQILSGQKE--LHDLLLVSANpsDFHFCSCGAVTVESLDDAEELLATEQAMDILGFL 354
Cdd:cd14919   161 ETYLLEKSRAIRQAKEERTFHIFYYLLSGAGEhlKTDLLLEPYN--KYRFLSNGHVTIPGQQDKDMFQETMEAMRIMGIP 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  355 PDEKYGCYKLTGAIMHFGNMKFKQKPREEQLEADGTENADKAAFLMGINSSELVKCLIHPRIKVGNEYVTRGQTIEQVTC 434
Cdd:cd14919   239 EEEQMGLLRVISGVLQLGNIVFKKERNTDQASMPDNTAAQKVSHLLGINVTDFTRGILTPRIKVGRDYVQKAQTKEQADF 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  435 AVGALSKSMYERMFKWLVARINRALDaKLSRQ--FFIGILDITGFEILEYNSLEQLCINFTNEKLQQFFNWHMFVLEQEE 512
Cdd:cd14919   319 AIEALAKATYERMFRWLVLRINKALD-KTKRQgaSFIGILDIAGFEIFDLNSFEQLCINYTNEKLQQLFNHTMFILEQEE 397
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  513 YKKESIEWVSIGFGLDLQACIDLIEKPM---GILSILEEECMFPKATDLTFKTKLFDNHfGKSVHLQKPKPDKKKfeAHF 589
Cdd:cd14919   398 YQREGIEWNFIDFGLDLQPCIDLIEKPAgppGILALLDEECWFPKATDKSFVEKVVQEQ-GTHPKFQKPKQLKDK--ADF 474
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  590 ELVHYAGVVPYNISGWLEKNKDLLNETVVAVFQKSSNRLLASLFENYMS----------TDSAIPFGEKKRKkgASFQTV 659
Cdd:cd14919   475 CIIHYAGKVDYKADEWLMKNMDPLNDNIATLLHQSSDKFVSELWKDVDRiigldqvagmSETALPGAFKTRK--GMFRTV 552
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  660 ASLHKENLNKLMTNLKSTAPHFVRCINPNVNKIPGILDPYLVLQQLRCNGVLEGTRICREGFPNRLQYADFKQRYCILNP 739
Cdd:cd14919   553 GQLYKEQLAKLMATLRNTNPNFVRCIIPNHEKKAGKLDPHLVLDQLRCNGVLEGIRICRQGFPNRVVFQEFRQRYEILTP 632
                         650       660       670
                  ....*....|....*....|....*....|....*....
gi 767926067  740 RTFPKSkFVSSRKAAEELLGSLEIDHTQYRFGITKVFFK 778
Cdd:cd14919   633 NSIPKG-FMDGKQACVLMIKALELDSNLYRIGQSKVFFR 670
MYSc_Myh19 cd15896
class II myosin heavy chain19, motor domain; Myosin motor domain of muscle myosin heavy chain ...
117-778 0e+00

class II myosin heavy chain19, motor domain; Myosin motor domain of muscle myosin heavy chain 19. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276899 [Multi-domain]  Cd Length: 675  Bit Score: 638.26  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  117 ASVLHTLKRRYGQWMIYTYSGLFCVTINPYKWLPVYQKEVMAAYKGKRRSEAPPHIFAVANNAFQDMLHNRENQSILFTG 196
Cdd:cd15896     1 ASVLHNLKERYYSGLIYTYSGLFCVVINPYKNLPIYSEEIVEMYKGKKRHEMPPHIYAITDTAYRSMMQDREDQSILCTG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  197 ESGAGKTVNSKHIIQYFATIAAMIESRKKQ-------GALEDQIMQANTILEAFGNAKTLRNDNSSRFGKFIRMHFGARG 269
Cdd:cd15896    81 ESGAGKTENTKKVIQYLAHVASSHKTKKDQnslalshGELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVNG 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  270 MLSSVDIDIYLLEKSRVIFQQAGERNYHIFYQILS--GQKELHDLLLVSANpsDFHFCSCGAVTVESLDDAEELLATEQA 347
Cdd:cd15896   161 YIVGANIETYLLEKSRAIRQAKEERTFHIFYYLLTgaGDKLRSELLLENYN--NYRFLSNGNVTIPGQQDKDLFTETMEA 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  348 MDILGFLPDEKYGCYKLTGAIMHFGNMKFKQKPREEQLEADGTENADKAAFLMGINSSELVKCLIHPRIKVGNEYVTRGQ 427
Cdd:cd15896   239 FRIMGIPEDEQIGMLKVVASVLQLGNMSFKKERHTDQASMPDNTAAQKVCHLMGMNVTDFTRAILSPRIKVGRDYVQKAQ 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  428 TIEQVTCAVGALSKSMYERMFKWLVARINRALDaKLSRQ--FFIGILDITGFEILEYNSLEQLCINFTNEKLQQFFNWHM 505
Cdd:cd15896   319 TQEQAEFAVEALAKATYERMFRWLVMRINKALD-KTKRQgaSFIGILDIAGFEIFELNSFEQLCINYTNEKLQQLFNHTM 397
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  506 FVLEQEEYKKESIEWVSIGFGLDLQACIDLIEKPM---GILSILEEECMFPKATDLTFKTKLFDNhfgKSVHLQKPKPDK 582
Cdd:cd15896   398 FILEQEEYQREGIEWSFIDFGLDLQPCIDLIEKPAsppGILALLDEECWFPKATDKSFVEKVLQE---QGTHPKFFKPKK 474
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  583 KKFEAHFELVHYAGVVPYNISGWLEKNKDLLNETVVAVFQKSSNRLLASLFENY--------MSTDSAIPFGEKKRKkgA 654
Cdd:cd15896   475 LKDEADFCIIHYAGKVDYKADEWLMKNMDPLNDNVATLLNQSTDKFVSELWKDVdrivgldkVSGMSEMPGAFKTRK--G 552
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  655 SFQTVASLHKENLNKLMTNLKSTAPHFVRCINPNVNKIPGILDPYLVLQQLRCNGVLEGTRICREGFPNRLQYADFKQRY 734
Cdd:cd15896   553 MFRTVGQLYKEQLSKLMATLRNTNPNFVRCIIPNHEKKAGKLDPHLVLDQLRCNGVLEGIRICRQGFPNRIVFQEFRQRY 632
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|....
gi 767926067  735 CILNPRTFPKSkFVSSRKAAEELLGSLEIDHTQYRFGITKVFFK 778
Cdd:cd15896   633 EILTPNAIPKG-FMDGKQACVLMIKSLELDPNLYRIGQSKVFFR 675
MYSc_Myh14_mammals cd14930
class II myosin heavy chain 14 motor domain; Myosin motor domain of non-muscle myosin heavy ...
117-778 0e+00

class II myosin heavy chain 14 motor domain; Myosin motor domain of non-muscle myosin heavy chain 14 (also called FLJ13881, KIAA2034, MHC16, MYH17). Its members include mammals, chickens, and turtles. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. Some of the data used for this classification were produced by the CyMoBase team at the Max-Planck-Institute for Biophysical Chemistry. The sequence names are composed of the species abbreviation followed by the protein abbreviation and optional protein classifier and variant designations.


Pssm-ID: 276893 [Multi-domain]  Cd Length: 670  Bit Score: 618.65  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  117 ASVLHTLKRRYGQWMIYTYSGLFCVTINPYKWLPVYQKEVMAAYKGKRRSEAPPHIFAVANNAFQDMLHNRENQSILFTG 196
Cdd:cd14930     1 ASVLHNLRERYYSGLIYTYSGLFCVVINPYKQLPIYTEAIVEMYRGKKRHEVPPHVYAVTEGAYRSMLQDREDQSILCTG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  197 ESGAGKTVNSKHIIQYFATIAAMIESRKKQGA---LEDQIMQANTILEAFGNAKTLRNDNSSRFGKFIRMHFGARGMLSS 273
Cdd:cd14930    81 ESGAGKTENTKKVIQYLAHVASSPKGRKEPGVpgeLERQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVAGYIVG 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  274 VDIDIYLLEKSRVIFQQAGERNYHIFYQILSGQKELHDLLLVSANPSDFHFCSCGAVTVESlDDAEELLATEQAMDILGF 353
Cdd:cd14930   161 ANIETYLLEKSRAIRQAKDECSFHIFYQLLGGAGEQLKADLLLEPCSHYRFLTNGPSSSPG-QERELFQETLESLRVLGF 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  354 LPDEKYGCYKLTGAIMHFGNMKFKQKPREEQLEADGTENADKAAFLMGINSSELVKCLIHPRIKVGNEYVTRGQTIEQVT 433
Cdd:cd14930   240 SHEEITSMLRMVSAVLQFGNIVLKRERNTDQATMPDNTAAQKLCRLLGLGVTDFSRALLTPRIKVGRDYVQKAQTKEQAD 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  434 CAVGALSKSMYERMFKWLVARINRALDaKLSRQ--FFIGILDITGFEILEYNSLEQLCINFTNEKLQQFFNWHMFVLEQE 511
Cdd:cd14930   320 FALEALAKATYERLFRWLVLRLNRALD-RSPRQgaSFLGILDIAGFEIFQLNSFEQLCINYTNEKLQQLFNHTMFVLEQE 398
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  512 EYKKESIEWVSIGFGLDLQACIDLIEKPM---GILSILEEECMFPKATDLTFKTKLFDNhfgKSVHLQKPKPDKKKFEAH 588
Cdd:cd14930   399 EYQREGIPWTFLDFGLDLQPCIDLIERPAnppGLLALLDEECWFPKATDKSFVEKVAQE---QGGHPKFQRPRHLRDQAD 475
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  589 FELVHYAGVVPYNISGWLEKNKDLLNETVVAVFQKSSNRLLASLF---------ENYMSTDSAIPFGEKKRkkgASFQTV 659
Cdd:cd14930   476 FSVLHYAGKVDYKANEWLMKNMDPLNDNVAALLHQSTDRLTAEIWkdvegivglEQVSSLGDGPPGGRPRR---GMFRTV 552
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  660 ASLHKENLNKLMTNLKSTAPHFVRCINPNVNKIPGILDPYLVLQQLRCNGVLEGTRICREGFPNRLQYADFKQRYCILNP 739
Cdd:cd14930   553 GQLYKESLSRLMATLSNTNPSFVRCIVPNHEKRAGKLEPRLVLDQLRCNGVLEGIRICRQGFPNRILFQEFRQRYEILTP 632
                         650       660       670
                  ....*....|....*....|....*....|....*....
gi 767926067  740 RTFPKSkFVSSRKAAEELLGSLEIDHTQYRFGITKVFFK 778
Cdd:cd14930   633 NAIPKG-FMDGKQACEKMIQALELDPNLYRVGQSKIFFR 670
MYSc_Myo8 cd01383
class VIII myosin, motor domain; These plant-specific type VIII myosins has been associated ...
118-778 0e+00

class VIII myosin, motor domain; These plant-specific type VIII myosins has been associated with endocytosis, cytokinesis, cell-to-cell coupling and gating at plasmodesmata. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. It also contains IQ domains Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276834  Cd Length: 647  Bit Score: 607.01  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  118 SVLHTLKRRYGQWMIYTYSGLFCVTINPYKWLPVYQKEVMAAYkGKRRSEaPPHIFAVANNAFQDMLHNRENQSILFTGE 197
Cdd:cd01383     2 SVLHNLEYRYSQDIIYTKAGPVLIAVNPFKDVPLYGNEFITAY-RQKLLD-SPHVYAVADTAYREMMRDEINQSIIISGE 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  198 SGAGKTVNSKHIIQYFATIAAmiesrkKQGALEDQIMQANTILEAFGNAKTLRNDNSSRFGKFIRMHFGARGMLSSVDID 277
Cdd:cd01383    80 SGAGKTETAKIAMQYLAALGG------GSSGIENEILQTNPILEAFGNAKTLRNDNSSRFGKLIDIHFDAAGKICGAKIQ 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  278 IYLLEKSRVIFQQAGERNYHIFYQILSG-QKELHDLLLVSAnPSDFHFCS-CGAVTVESLDDAEELLATEQAMDILGFLP 355
Cdd:cd01383   154 TYLLEKSRVVQLANGERSYHIFYQLCAGaSPALREKLNLKS-ASEYKYLNqSNCLTIDGVDDAKKFHELKEALDTVGISK 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  356 DEKYGCYKLTGAIMHFGNMKFKQKPREEQLEADGTENADKAAFLMGINSSELVKCLIHPRIKVGNEYVTRGQTIEQVTCA 435
Cdd:cd01383   233 EDQEHIFQMLAAVLWLGNISFQVIDNENHVEVVADEAVSTAASLLGCNANDLMLALSTRKIQAGGDKIVKKLTLQQAIDA 312
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  436 VGALSKSMYERMFKWLVARINRALDAKLSRQF-FIGILDITGFEILEYNSLEQLCINFTNEKLQQFFNWHMFVLEQEEYK 514
Cdd:cd01383   313 RDALAKAIYASLFDWLVEQINKSLEVGKRRTGrSISILDIYGFESFQKNSFEQLCINYANERLQQHFNRHLFKLEQEEYE 392
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  515 KESIEWVSIGFgLDLQACIDLIE-KPMGILSILEEECMFPKATDLTFKTKLfdnhfgkSVHLQKPKPDKKKFEAHFELVH 593
Cdd:cd01383   393 LDGIDWTKVDF-EDNQECLDLIEkKPLGLISLLDEESNFPKATDLTFANKL-------KQHLKSNSCFKGERGGAFTIRH 464
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  594 YAGVVPYNISGWLEKNKDLLNETVVAVFQkSSNRLLASLFENYMSTDSAIPFGEKKRKKGASF-QTVASLHKENLNKLMT 672
Cdd:cd01383   465 YAGEVTYDTSGFLEKNRDLLHSDLIQLLS-SCSCQLPQLFASKMLDASRKALPLTKASGSDSQkQSVATKFKGQLFKLMQ 543
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  673 NLKSTAPHFVRCINPNVNKIPGILDPYLVLQQLRCNGVLEGTRICREGFPNRLQYADFKQRYCILNPRTFPKSKFVSSRK 752
Cdd:cd01383   544 RLENTTPHFIRCIKPNNKQLPGVFDQDLVLQQLRCCGVLEVVRISRSGYPTRMTHQEFARRYGFLLPEDVSASQDPLSTS 623
                         650       660
                  ....*....|....*....|....*.
gi 767926067  753 AAeeLLGSLEIDHTQYRFGITKVFFK 778
Cdd:cd01383   624 VA--ILQQFNILPEMYQVGYTKLFFR 647
MYSc_Myo7 cd01381
class VII myosin, motor domain; These monomeric myosins have been associated with functions in ...
117-778 0e+00

class VII myosin, motor domain; These monomeric myosins have been associated with functions in sensory systems such as vision and hearing. Mammalian myosin VII has a tail with 2 MyTH4 domains, 2 FERM domains, and a SH3 domain. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276832  Cd Length: 648  Bit Score: 606.17  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  117 ASVLHTLKRRYGQWMIYTYSGLFCVTINPYKWLPVYQKEVMAAYKGKRRSEAPPHIFAVANNAFQDMLHNRENQSILFTG 196
Cdd:cd01381     1 AGILRNLLIRYREKLIYTYTGSILVAVNPYQILPIYTAEQIRLYRNKKIGELPPHIFAIADNAYTNMKRNKRDQCVVISG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  197 ESGAGKTVNSKHIIQYFATIAAmiesrkKQGALEDQIMQANTILEAFGNAKTLRNDNSSRFGKFIRMHFGARGMLSSVDI 276
Cdd:cd01381    81 ESGAGKTESTKLILQYLAAISG------QHSWIEQQILEANPILEAFGNAKTIRNDNSSRFGKYIDIHFNKNGVIEGAKI 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  277 DIYLLEKSRVIFQQAGERNYHIFYQILSG----QKELHDLllvsANPSDFHFCSCG-AVTVESLDDAEELLATEQAMDIL 351
Cdd:cd01381   155 EQYLLEKSRIVSQAPDERNYHIFYCMLAGlsaeEKKKLEL----GDASDYYYLTQGnCLTCEGRDDAAEFADIRSAMKVL 230
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  352 GFLPDEKYGCYKLTGAIMHFGNMKFKQKPRE--EQLEADGTENADKAAFLMGINSSELVKCLIHPRIKVGNEYVTRGQTI 429
Cdd:cd01381   231 MFTDEEIWDIFKLLAAILHLGNIKFEATVVDnlDASEVRDPPNLERAAKLLEVPKQDLVDALTTRTIFTRGETVVSPLSA 310
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  430 EQVTCAVGALSKSMYERMFKWLVARINRAL---DAKLSRQFFIGILDITGFEILEYNSLEQLCINFTNEKLQQFFNWHMF 506
Cdd:cd01381   311 EQALDVRDAFVKGIYGRLFIWIVNKINSAIykpRGTDSSRTSIGVLDIFGFENFEVNSFEQLCINFANENLQQFFVRHIF 390
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  507 VLEQEEYKKESIEWVSIGFgLDLQACIDLI-EKPMGILSILEEECMFPKATDLTFKTKLFDNHFGKSVHLqKPKPDkkkF 585
Cdd:cd01381   391 KLEQEEYDKEGINWQHIEF-VDNQDVLDLIaLKPMNIMSLIDEESKFPKGTDQTMLEKLHSTHGNNKNYL-KPKSD---L 465
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  586 EAHFELVHYAGVVPYNISGWLEKNKDLLNETVVAVFQKSSNRLLASLFENYMStdsaipFGEKKRKKGasfQTVASLHKE 665
Cdd:cd01381   466 NTSFGINHFAGVVFYDTRGFLEKNRDTFSADLLQLVQSSKNKFLKQLFNEDIS------MGSETRKKS---PTLSSQFRK 536
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  666 NLNKLMTNLKSTAPHFVRCINPNVNKIPGILDPYLVLQQLRCNGVLEGTRICREGFPNRLQYADFKQRYCILNPRTfPKS 745
Cdd:cd01381   537 SLDQLMKTLSACQPFFVRCIKPNEYKKPMLFDRELCVRQLRYSGMMETIRIRKAGYPIRHTFEEFVERYRVLVPGI-PPA 615
                         650       660       670
                  ....*....|....*....|....*....|...
gi 767926067  746 KFVSSRKAAEELLGSLEIDHTQYRFGITKVFFK 778
Cdd:cd01381   616 HKTDCRAATRKICCAVLGGDADYQLGKTKIFLK 648
MYSc_Myo1 cd01378
class I myosin, motor domain; Myosin I generates movement at the leading edge in cell motility, ...
118-778 0e+00

class I myosin, motor domain; Myosin I generates movement at the leading edge in cell motility, and class I myosins have been implicated in phagocytosis and vesicle transport. Myosin I, an unconventional myosin, does not form dimers. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. There are 5 myosin subclasses with subclasses c/h, d/g, and a/b have an IQ domain and a TH1 domain. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276829  Cd Length: 652  Bit Score: 604.92  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  118 SVLHTLKRRYGQWMIYTYSGLFCVTINPYKWLPVYQKEVMAAYKGKRRSEAPPHIFAVANNAFQDMLHNRENQSILFTGE 197
Cdd:cd01378     2 AINENLKKRFENDEIYTYIGHVLISVNPFKDLGIYTDEVLESYRGKNRYEVPPHVFALADSAYRNMKSEKENQCVIISGE 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  198 SGAGKTVNSKHIIQYFATIAAMIESrkKQGALEDQIMQANTILEAFGNAKTLRNDNSSRFGKFIRMHFGARGMLSSVDID 277
Cdd:cd01378    82 SGAGKTEASKRIMQYIAAVSGGSES--EVERVKDMLLASNPLLEAFGNAKTLRNDNSSRFGKYMEIQFDFKGEPVGGHIT 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  278 IYLLEKSRVIFQQAGERNYHIFYQILSG--QKELHDLLLVSaNPSDFHFCSCGAVTVESLDDAEELLATEQAMDILGFLP 355
Cdd:cd01378   160 NYLLEKSRVVGQIKGERNFHIFYQLLKGasQEYLQELGLQR-PEQYYYYSKSGCFDVDGIDDAADFKEVLNAMKVIGFTE 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  356 DEKYGCYKLTGAIMHFGNMKFKQKPREEQLEADGTEnADKAAFLMGINSSELVKCLIHPRIKVGNEY---VTRGQTIEQV 432
Cdd:cd01378   239 EEQDSIFRILAAILHLGNIQFAEDEEGNAAISDTSV-LDFVAYLLGVDPDQLEKALTHRTIETGGGGrsvYEVPLNVEQA 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  433 TCAVGALSKSMYERMFKWLVARINRALDAKLSRQ-FFIGILDITGFEILEYNSLEQLCINFTNEKLQQFFnwHMFVL--E 509
Cdd:cd01378   318 AYARDALAKAIYSRLFDWIVERINKSLAAKSGGKkKVIGVLDIYGFEIFEKNSFEQFCINYVNEKLQQIF--IELTLkaE 395
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  510 QEEYKKESIEWVSIGFgLDLQACIDLIE-KPMGILSILEEECMFP-KATDLTFKTKLfDNHFGKSVHLQKPKPDKKKFEA 587
Cdd:cd01378   396 QEEYVREGIEWTPIKY-FNNKIICDLIEeKPPGIFAILDDACLTAgDATDQTFLQKL-NQLFSNHPHFECPSGHFELRRG 473
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  588 HFELVHYAGVVPYNISGWLEKNKDLLNETVVAVFQKSSNRLLASLFENYMSTDSaipfgeKKRKKGASFQTVASlhkenL 667
Cdd:cd01378   474 EFRIKHYAGDVTYNVEGFLDKNKDLLFKDLKELMQSSSNPFLRSLFPEGVDLDS------KKRPPTAGTKFKNS-----A 542
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  668 NKLMTNLKSTAPHFVRCINPNVNKIPGILDPYLVLQQLRCNGVLEGTRICREGFPNRLQYADFKQRYCILNPRTFPKSKF 747
Cdd:cd01378   543 NALVETLMKKQPSYIRCIKPNDNKSPGEFDEELVLHQVKYLGLLENVRVRRAGFAYRQTYEKFLERYKLLSPKTWPAWDG 622
                         650       660       670
                  ....*....|....*....|....*....|.
gi 767926067  748 vSSRKAAEELLGSLEIDHTQYRFGITKVFFK 778
Cdd:cd01378   623 -TWQGGVESILKDLNIPPEEYQMGKTKIFIR 652
MYSc_Myo22 cd14883
class XXII myosin, motor domain; These myosins possess an extended neck with multiple IQ ...
118-778 0e+00

class XXII myosin, motor domain; These myosins possess an extended neck with multiple IQ motifs such as found in class V, VIII, XI, and XIII myosins. These myosins are defined by two tandem MyTH4 and FERM domains. The apicomplexan, but not diatom myosins contain 4-6 WD40 repeats near the end of the C-terminal tail which suggests a possible function of these myosins in signal transduction and transcriptional regulation. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276849 [Multi-domain]  Cd Length: 661  Bit Score: 602.39  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  118 SVLHTLKRRYGQWMIYTYSGLFCVTINPYKWLPVYQKEVMAAYKGKRRSEAPPHIFAVANNAFQDMLHNRENQSILFTGE 197
Cdd:cd14883     2 GINTNLKVRYKKDLIYTYTGSILVAVNPYKELPIYTQDIVKQYFGKRMGALPPHIFALAEAAYTNMQEDGKNQSVIISGE 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  198 SGAGKTVNSKHIIQYFATIAAmiesrkKQGALEDQIMQANTILEAFGNAKTLRNDNSSRFGKFIRMHFGARGMLSSVDID 277
Cdd:cd14883    82 SGAGKTETTKLILQYLCAVTN------NHSWVEQQILEANTILEAFGNAKTVRNDNSSRFGKFIEVCFDASGHIKGAIIQ 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  278 IYLLEKSRVIFQQAGERNYHIFYQILSG---QKELHDLLLVSaNPSDFHFCS-CGAVTVESLDDAEELLATEQAMDILGF 353
Cdd:cd14883   156 DYLLEQSRITFQAPGERNYHVFYQLLAGakhSKELKEKLKLG-EPEDYHYLNqSGCIRIDNINDKKDFDHLRLAMNVLGI 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  354 LPDEKYGCYKLTGAIMHFGNMKFKQKPREE-QLEADGTENADKAAFLMGINSSELVKCLIHPRIKVGNEYVTRGQTIEQV 432
Cdd:cd14883   235 PEEMQEGIFSVLSAILHLGNLTFEDIDGETgALTVEDKEILKIVAKLLGVDPDKLKKALTIRQINVRGNVTEIPLKVQEA 314
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  433 TCAVGALSKSMYERMFKWLVARINRALDAKLSRQFFIGILDITGFEILEYNSLEQLCINFTNEKLQQFFNWHMFVLEQEE 512
Cdd:cd14883   315 RDNRDAMAKALYSRTFAWLVNHINSCTNPGQKNSRFIGVLDIFGFENFKVNSFEQLCINYTNEKLHKFFNHYVFKLEQEE 394
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  513 YKKESIEWVSIGFGlDLQACIDLIEK-PMGILSILEEECMFPKATDLTFKTKLFDNHfgkSVHLQKPKPDKKKFEAHFEL 591
Cdd:cd14883   395 YEKEGINWSHIVFT-DNQECLDLIEKpPLGILKLLDEECRFPKGTDLTYLEKLHAAH---EKHPYYEKPDRRRWKTEFGV 470
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  592 VHYAGVVPYNISGWLEKNKDLLNETVVAVFQKSSNRLLASLF---ENYMSTDSAIPFGE----KKRKKGASfqTVASLHK 664
Cdd:cd14883   471 KHYAGEVTYTVQGFLDKNKDTQQDDLFDLMSRSKNKFVKELFtypDLLALTGLSISLGGdttsRGTSKGKP--TVGDTFK 548
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  665 ENLNKLMTNLKSTAPHFVRCINPNVNKIPGILDPYLVLQQLRCNGVLEGTRICREGFPNRLQYADFKQRYCILNPRTFPK 744
Cdd:cd14883   549 HQLQSLVDVLSATQPWYVRCIKPNSLKEPNVFDDELVLAQLRYAGMLEIIRIRKEGFPIHLTFKEFVDRYLCLDPRARSA 628
                         650       660       670
                  ....*....|....*....|....*....|....
gi 767926067  745 SKfVSSRKAAEELLGSLEIDHTQYRFGITKVFFK 778
Cdd:cd14883   629 DH-KETCGAVRALMGLGGLPEDEWQVGKTKVFLR 661
MYSc_Myo11 cd01384
class XI myosin, motor domain; These plant-specific type XI myosin are involved in organelle ...
117-778 3.94e-179

class XI myosin, motor domain; These plant-specific type XI myosin are involved in organelle transport. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle.


Pssm-ID: 276835  Cd Length: 647  Bit Score: 558.06  E-value: 3.94e-179
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  117 ASVLHTLKRRYGQWMIYTYSGLFCVTINPYKWLP-VYQKEVMAAYKGKRRSEAPPHIFAVANNAFQDMLHNRENQSILFT 195
Cdd:cd01384     1 PGVLHNLKVRYELDEIYTYTGNILIAVNPFKRLPhLYDAHMMEQYKGAPLGELSPHVFAVADAAYRAMINEGKSQSILVS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  196 GESGAGKTVNSKHIIQYFATIAAMIESrkKQGALEDQIMQANTILEAFGNAKTLRNDNSSRFGKFIRMHFGARGMLSSVD 275
Cdd:cd01384    81 GESGAGKTETTKMLMQYLAYMGGRAVT--EGRSVEQQVLESNPLLEAFGNAKTVRNNNSSRFGKFVEIQFDDAGRISGAA 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  276 IDIYLLEKSRVIFQQAGERNYHIFYQILSG--QKELHDLLLvsANPSDFHF---CSCgaVTVESLDDAEELLATEQAMDI 350
Cdd:cd01384   159 IRTYLLERSRVVQVSDPERNYHCFYQLCAGapPEDREKYKL--KDPKQFHYlnqSKC--FELDGVDDAEEYRATRRAMDV 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  351 LGFLPDEKYGCYKLTGAIMHFGNMKFKQKPreeqlEADGTENADK--------AAFLMGINSSELVKCLIHPRIKVGNEY 422
Cdd:cd01384   235 VGISEEEQDAIFRVVAAILHLGNIEFSKGE-----EDDSSVPKDEksefhlkaAAELLMCDEKALEDALCKRVIVTPDGI 309
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  423 VTRGQTIEQVTCAVGALSKSMYERMFKWLVARINRALDAKLSRQFFIGILDITGFEILEYNSLEQLCINFTNEKLQQFFN 502
Cdd:cd01384   310 ITKPLDPDAATLSRDALAKTIYSRLFDWLVDKINRSIGQDPNSKRLIGVLDIYGFESFKTNSFEQFCINLANEKLQQHFN 389
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  503 WHMFVLEQEEYKKESIEWVSIGFgLDLQACIDLIE-KPMGILSILEEECMFPKATDLTFKTKLFDNhFGKSVHLQKPKPD 581
Cdd:cd01384   390 QHVFKMEQEEYTKEEIDWSYIEF-VDNQDVLDLIEkKPGGIIALLDEACMFPRSTHETFAQKLYQT-LKDHKRFSKPKLS 467
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  582 KKKfeahFELVHYAGVVPYNISGWLEKNKDLLNETVVAVFQKSSNRLLASLFEnymstdsaiPFGEKKRKKGASFQTVAS 661
Cdd:cd01384   468 RTD----FTIDHYAGDVTYQTDLFLDKNKDYVVAEHQALLNASKCPFVAGLFP---------PLPREGTSSSSKFSSIGS 534
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  662 LHKENLNKLMTNLKSTAPHFVRCINPN-VNKiPGILDPYLVLQQLRCNGVLEGTRICREGFPNRLQYADFKQRYCILNPR 740
Cdd:cd01384   535 RFKQQLQELMETLNTTEPHYIRCIKPNnLLK-PGIFENANVLQQLRCGGVLEAVRISCAGYPTRKPFEEFLDRFGLLAPE 613
                         650       660       670
                  ....*....|....*....|....*....|....*...
gi 767926067  741 TFPKSKfvSSRKAAEELLGSLEIDhtQYRFGITKVFFK 778
Cdd:cd01384   614 VLKGSD--DEKAACKKILEKAGLK--GYQIGKTKVFLR 647
MYSc_Myo6 cd01382
class VI myosin, motor domain; Myosin VI is a monomeric myosin, which moves towards the ...
117-778 1.30e-169

class VI myosin, motor domain; Myosin VI is a monomeric myosin, which moves towards the minus-end of actin filaments, in contrast to most other myosins which moves towards the plus-end of actin filaments. It is thought that myosin VI, unlike plus-end directed myosins, does not use a pure lever arm mechanism, but instead steps with a mechanism analogous to the kinesin neck-linker uncoupling model. It has been implicated in a myriad of functions including: the transport of cytoplasmic organelles, maintenance of normal Golgi morphology, endocytosis, secretion, cell migration, border cell migration during development, and in cancer metastasis playing roles in deafness and retinal development among others. While how this is accomplished is largely unknown there are several interacting proteins that have been identified such as disabled homolog 2 (DAB2), GIPC1, synapse-associated protein 97 (SAP97; also known as DLG1) and optineurin, which have been found to target myosin VI to different cellular compartments. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the minus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276833  Cd Length: 649  Bit Score: 532.21  E-value: 1.30e-169
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  117 ASVLHTLKRRYGQWMIYTYSGLFCVTINPYKWLP-VYQKEVMAAYKGKRRSEAPPHIFAVANNAFQDMLHNRENQSILFT 195
Cdd:cd01382     1 ATLLNNIRVRYSKDKIYTYVANILIAVNPYFDIPkLYSSETIKSYQGKSLGTLPPHVFAIADKAYRDMKVLKQSQSIIVS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  196 GESGAGKTVNSKHIIQYfatiaaMIESR-KKQGALEDQIMQANTILEAFGNAKTLRNDNSSRFGKFIRMHFGARGMLSSV 274
Cdd:cd01382    81 GESGAGKTESTKYILRY------LTESWgSGAGPIEQRILEANPLLEAFGNAKTVRNNNSSRFGKFVEIHFNEKSSVVGG 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  275 DIDIYLLEKSRVIFQQAGERNYHIFYQILSG------QKELHDLLlvsanpsdfhfcscgavtvesLDDAEELLATEQAM 348
Cdd:cd01382   155 FVSHYLLEKSRICVQSKEERNYHIFYRLCAGapedlrEKLLKDPL---------------------LDDVGDFIRMDKAM 213
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  349 DILGFLPDEKYGCYKLTGAIMHFGNMKFKQKPREE----QLEADGTENADKAAFLMGINSSELVKCLIHpRIKVGNEYVT 424
Cdd:cd01382   214 KKIGLSDEEKLDIFRVVAAVLHLGNIEFEENGSDSgggcNVKPKSEQSLEYAAELLGLDQDELRVSLTT-RVMQTTRGGA 292
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  425 RGQTI------EQVTCAVGALSKSMYERMFKWLVARINRALDAKLSrQFFIGILDITGFEILEYNSLEQLCINFTNEKLQ 498
Cdd:cd01382   293 KGTVIkvplkvEEANNARDALAKAIYSKLFDHIVNRINQCIPFETS-SYFIGVLDIAGFEYFEVNSFEQFCINYCNEKLQ 371
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  499 QFFNWHMFVLEQEEYKKESIEWVSIGFgLDLQACIDLIE-KPMGILSILEEECMFPKATdltfktklfDNHFGKSVHLQK 577
Cdd:cd01382   372 QFFNERILKEEQELYEKEGLGVKEVEY-VDNQDCIDLIEaKLVGILDLLDEESKLPKPS---------DQHFTSAVHQKH 441
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  578 PK------PDKKKFEAHFELV--------HYAGVVPYNISGWLEKNKDLLNETVVAVFQKSSNRLLASLFENYMSTDSai 643
Cdd:cd01382   442 KNhfrlsiPRKSKLKIHRNLRddegflirHFAGAVCYETAQFIEKNNDALHASLESLICESKDKFIRSLFESSTNNNK-- 519
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  644 pfGEKKRKKGASFQTVASLHKENLNKLMTNLKSTAPHFVRCINPNVNKIPGILDPYLVLQQLRCNGVLEGTRICREGFPN 723
Cdd:cd01382   520 --DSKQKAGKLSFISVGNKFKTQLNLLMDKLRSTGTSFIRCIKPNLKMTSHHFEGAQILSQLQCSGMVSVLDLMQGGFPS 597
                         650       660       670       680       690       700
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767926067  724 RLQYADFKQRY--------CILNPRTFPKSKFvssrKAaeelLGSLEIDhtqYRFGITKVFFK 778
Cdd:cd01382   598 RTSFHDLYNMYkkylppklARLDPRLFCKALF----KA----LGLNEND---FKFGLTKVFFR 649
MYSc_Myo4 cd14872
class IV myosin, motor domain; These myosins all possess a WW domain either N-terminal or ...
117-778 2.68e-166

class IV myosin, motor domain; These myosins all possess a WW domain either N-terminal or C-terminal to their motor domain and a tail with a MyTH4 domain followed by a SH3 domain in some instances. The monomeric Acanthamoebas were the first identified members of this group and have been joined by Stramenopiles. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276839  Cd Length: 644  Bit Score: 523.18  E-value: 2.68e-166
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  117 ASVLHTLKRRYGQWMIYTYSGLFCVTINPYKWLPVYQKEVMAAYKGKRRSEAPPHIFAVANNAFQDMLHNRENQSILFTG 196
Cdd:cd14872     1 AMIVHNLRKRFKNDQIYTNVGTILISVNPFKRLPLYTPTVMDQYMHKGPKEMPPHTYNIADDAYRAMIVDAMNQSILISG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  197 ESGAGKTVNSKHIIQYFATIAAmiesrkKQGALEDQIMQANTILEAFGNAKTLRNDNSSRFGKFIRMHFGARGMLSSVDI 276
Cdd:cd14872    81 ESGAGKTEATKQCLSFFAEVAG------STNGVEQRVLLANPILEAFGNAKTLRNNNSSRFGKWVEIHFDNRGRICGAST 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  277 DIYLLEKSRVIFQQAGERNYHIFYQILSGQKELHDLLLVSAnpSDFHFCSC-GAVTVESLDDAEELLATEQAMDILGFLP 355
Cdd:cd14872   155 ENYLLEKSRVVYQIKGERNFHIFYQLLASPDPASRGGWGSS--AAYGYLSLsGCIEVEGVDDVADFEEVVLAMEQLGFDD 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  356 DEKYGCYKLTGAIMHFGNMKFKQKPREEQLEADGTENAD---KAAFLMGINSSELVKCLIHPRIKVGNEYVTRGQ-TIEQ 431
Cdd:cd14872   233 ADINNVMSLIAAILKLGNIEFASGGGKSLVSGSTVANRDvlkEVATLLGVDAATLEEALTSRLMEIKGCDPTRIPlTPAQ 312
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  432 VTCAVGALSKSMYERMFKWLVARINRALD-AKLSRQFFIGILDITGFEILEYNSLEQLCINFTNEKLQQFFNWHMFVLEQ 510
Cdd:cd14872   313 ATDACDALAKAAYSRLFDWLVKKINESMRpQKGAKTTFIGVLDIFGFEIFEKNSFEQLCINFTNEKLQQHFNQYTFKLEE 392
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  511 EEYKKESIEWVSIGFgLDLQACIDLIEK-PMGILSILEEECMFPKATDLTFKTKLFDNHFGKSVHLQKpkpDKKKFEAHF 589
Cdd:cd14872   393 ALYQSEGVKFEHIDF-IDNQPVLDLIEKkQPGLMLALDDQVKIPKGSDATFMIAANQTHAAKSTFVYA---EVRTSRTEF 468
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  590 ELVHYAGVVPYNISGWLEKNKDLLNETVVAVFQKSSNRLLASLFEnymstdsaiPF-GEKKRKKgasfQTVASLHKENLN 668
Cdd:cd14872   469 IVKHYAGDVTYDITGFLEKNKDTLQKDLYVLLSSSKNKLIAVLFP---------PSeGDQKTSK----VTLGGQFRKQLS 535
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  669 KLMTNLKSTAPHFVRCINPNVNKIPGILDPYLVLQQLRCNGVLEGTRICREGFPNRLQYADFKQRYCILnPRTFPKSKFV 748
Cdd:cd14872   536 ALMTALNATEPHYIRCVKPNQEKRARLFDGFMSLEQLRYAGVFEAVKIRKTGYPFRYSHERFLKRYRFL-VKTIAKRVGP 614
                         650       660       670
                  ....*....|....*....|....*....|
gi 767926067  749 SSRKAAEELLGSLEIDHTQYRFGITKVFFK 778
Cdd:cd14872   615 DDRQRCDLLLKSLKQDFSKVQVGKTRVLYR 644
MYSc_Myo3 cd01379
class III myosin, motor domain; Myosin III has been shown to play a role in the vision process ...
118-778 7.29e-166

class III myosin, motor domain; Myosin III has been shown to play a role in the vision process in insects and in hearing in mammals. Myosin III, an unconventional myosin, does not form dimers. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. They are characterized by an N-terminal protein kinase domain and several IQ domains. Some members also contain WW, SH2, PH, and Y-phosphatase domains. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276830 [Multi-domain]  Cd Length: 633  Bit Score: 521.45  E-value: 7.29e-166
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  118 SVLHTLKRRYGQWMIYTYSGLFCVTINPYKWLPVYQKEVMAAYKGKRRSEAPPHIFAVANNAFQDMLHNRENQSILFTGE 197
Cdd:cd01379     2 TIVSQLQKRYSRDQIYTYIGDILIAVNPFQNLGIYTEEHSRLYRGAKRSDNPPHIFAVADAAYQAMIHQKKNQCIVISGE 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  198 SGAGKTVNSKHIIQYFATIaamieSRKKQGALEDQIMQANTILEAFGNAKTLRNDNSSRFGKFIRMHFGARGMLSSVDID 277
Cdd:cd01379    82 SGAGKTESANLLVQQLTVL-----GKANNRTLEEKILQVNPLMEAFGNARTVINDNSSRFGKYLEMKFTSTGAVTGARIS 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  278 IYLLEKSRVIFQQAGERNYHIFYQILSG---QKELHDLLLVSANPSD-FHFCSCGAVTVESLD-DAEELLATEQAMDILG 352
Cdd:cd01379   157 EYLLEKSRVVHQAIGERNFHIFYYIYAGlaeDKKLAKYKLPENKPPRyLQNDGLTVQDIVNNSgNREKFEEIEQCFKVIG 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  353 FLPDEKYGCYKLTGAIMHFGNMKFKQKPREEQLEAD----GTENADKAAFLMGINSSELVKCLIHprikvgNEYVTRGQT 428
Cdd:cd01379   237 FTKEEVDSVYSILAAILHIGDIEFTEVESNHQTDKSsrisNPEALNNVAKLLGIEADELQEALTS------HSVVTRGET 310
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  429 I------EQVTCAVGALSKSMYERMFKWLVARINRALdaKLSR-----QFFIGILDITGFEILEYNSLEQLCINFTNEKL 497
Cdd:cd01379   311 IirnntvEEATDARDAMAKALYGRLFSWIVNRINSLL--KPDRsasdePLSIGILDIFGFENFQKNSFEQLCINIANEQI 388
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  498 QQFFNWHMFVLEQEEYKKESIEWVSIGFG-----LDLqacidLIEKPMGILSILEEECMFPKATDLTFKTKLFDNHfgKS 572
Cdd:cd01379   389 QYYFNQHIFAWEQQEYLNEGIDVDLIEYEdnrplLDM-----FLQKPMGLLALLDEESRFPKATDQTLVEKFHNNI--KS 461
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  573 VHLQKPKPDkkkfEAHFELVHYAGVVPYNISGWLEKNKDLLNETVVAVFQKSSNRLLAslfenymstdsaipfgekkrkk 652
Cdd:cd01379   462 KYYWRPKSN----ALSFGIHHYAGKVLYDASGFLEKNRDTLPPDVVQLLRSSENPLVR---------------------- 515
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  653 gasfQTVASLHKENLNKLMTNLKSTAPHFVRCINPNVNKIPGILDPYLVLQQLRCNGVLEGTRICREGFPNRLQYADFKQ 732
Cdd:cd01379   516 ----QTVATYFRYSLMDLLSKMVVGQPHFVRCIKPNDSRQAGKFDREKVLKQLRYTGVLETTRIRRQGFSHRILFADFLK 591
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|....*..
gi 767926067  733 RYCILnprTFPKSKFV-SSRKAAEELLGSLEIDHtqYRFGITKVFFK 778
Cdd:cd01379   592 RYYFL---AFKWNEEVvANRENCRLILERLKLDN--WALGKTKVFLK 633
MYSc_Myo27 cd14888
class XXVII myosin, motor domain; Not much is known about this myosin class. The catalytic ...
117-778 3.89e-164

class XXVII myosin, motor domain; Not much is known about this myosin class. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276853 [Multi-domain]  Cd Length: 667  Bit Score: 518.09  E-value: 3.89e-164
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  117 ASVLHTLKRRYGQWMIYTYSGLFCVTINPYKWLP-VYQKEVMAAYKGKRRSeAPPHIFAVANNAFQDMLHNRENQSILFT 195
Cdd:cd14888     1 ASILHSLNLRFDIDEIYTFTGPILIAVNPFKTIPgLYSDEMLLKFIQPSIS-KSPHVFSTASSAYQGMCNNKKSQTILIS 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  196 GESGAGKTVNSKHIIQYFATiaAMIESRKKQGALEDQIMQANTILEAFGNAKTLRNDNSSRFGKFIRMHF---------G 266
Cdd:cd14888    80 GESGAGKTESTKYVMKFLAC--AGSEDIKKRSLVEAQVLESNPLLEAFGNARTLRNDNSSRFGKFIELQFsklkskrmsG 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  267 ARGMLSSVDIDIYLLEKSRVIFQQAGERNYHIFYQILSGQKEL-----------------HDLLLVSANPSDFH------ 323
Cdd:cd14888   158 DRGRLCGAKIQTYLLEKVRVCDQQEGERNYHIFYQLCAAAREAkntglsyeendeklakgADAKPISIDMSSFEphlkfr 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  324 --FCScGAVTVESLDDAEELLATEQAMDILGFLPDEKYGCYKLTGAIMHFGNMKFK-QKPREE--QLEADGTENADKAAF 398
Cdd:cd14888   238 ylTKS-SCHELPDVDDLEEFESTLYAMQTVGISPEEQNQIFSIVAAILYLGNILFEnNEACSEgaVVSASCTDDLEKVAS 316
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  399 LMGINSSELVKCLIHPRIKVGNEYVTRGQTIEQVTCAVGALSKSMYERMFKWLVARINRALD-AKLSRQFFIGILDITGF 477
Cdd:cd14888   317 LLGVDAEDLLNALCYRTIKTAHEFYTKPLRVDEAEDVRDALARALYSCLFDKVVERTNESIGySKDNSLLFCGVLDIFGF 396
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  478 EILEYNSLEQLCINFTNEKLQQFFNWHMFVLEQEEYKKESIEWVSIGFGlDLQACIDLI-EKPMGILSILEEECMFPKAT 556
Cdd:cd14888   397 ECFQLNSFEQLCINFTNERLQQFFNNFVFKCEEKLYIEEGISWNPLDFP-DNQDCVDLLqEKPLGIFCMLDEECFVPGGK 475
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  557 DLTFKTKLFDNHFG-KSVHLQKPKPDKkkfeahFELVHYAGVVPYNISGWLEKNKDLLNETVVAVFQKSSNRLLASLFEN 635
Cdd:cd14888   476 DQGLCNKLCQKHKGhKRFDVVKTDPNS------FVIVHFAGPVKYCSDGFLEKNKDQLSVDAQEVIKNSKNPFISNLFSA 549
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  636 YMstDSAIPFGEKKRKkgasFQTVASLHKENLNKLMTNLKSTAPHFVRCINPNVNKIPGILDPYLVLQQLRCNGVLEGTR 715
Cdd:cd14888   550 YL--RRGTDGNTKKKK----FVTVSSEFRNQLDVLMETIDKTEPHFIRCIKPNSQNVPDLFDRISVNEQLKYGGVLQAVQ 623
                         650       660       670       680       690       700
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767926067  716 ICREGFPNRLQYADFKQRYCILNPrtfpkskfvssrkaaeellGSLEIDHTQYRFGITKVFFK 778
Cdd:cd14888   624 VSRAGYPVRLSHAEFYNDYRILLN-------------------GEGKKQLSIWAVGKTLCFFK 667
MYSc_Myo42 cd14903
class XLII myosin, motor domain; The class XLII myosins are comprised of Stramenopiles. Not ...
117-778 9.54e-162

class XLII myosin, motor domain; The class XLII myosins are comprised of Stramenopiles. Not much is known about this myosin class. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276868 [Multi-domain]  Cd Length: 658  Bit Score: 511.24  E-value: 9.54e-162
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  117 ASVLHTLKRRYGQWMIYTYSGLFCVTINPYKWLP-VYQKEVMAAYKGKRRSEAPPHIFAVANNAFQDMLHNRENQSILFT 195
Cdd:cd14903     1 AAILYNVKKRFLRKLPYTYTGDICIAVNPYQWLPeLYTEEQHSKYLNKPKEELPPHVYATSVAAYNHMKRSGRNQSILVS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  196 GESGAGKTVNSKHIIQYFATIAamiesrkkqGALED----QIMQANTILEAFGNAKTLRNDNSSRFGKFIRMHFGARGML 271
Cdd:cd14903    81 GESGAGKTETTKILMNHLATIA---------GGLNDstikKIIEVNPLLESFGNAKTVRNDNSSRFGKFTQLQFDKNGTL 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  272 SSVDIDIYLLEKSRVIFQQAGERNYHIFYQILSGQKELHDLLLVSANPSDFHFcSCGAVTVESLDDAEELLATEQAMDIL 351
Cdd:cd14903   152 VGAKCRTYLLEKTRVISHERPERNYHIFYQLLASPDVEERLFLDSANECAYTG-ANKTIKIEGMSDRKHFARTKEALSLI 230
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  352 GFLPDEKYGCYKLTGAIMHFGNMKFKQKPREEQLE--ADGTENADKAAFLMGINSSELVKCLIHPRIKVGNEYVTRGQTI 429
Cdd:cd14903   231 GVSEEKQEVLFEVLAGILHLGQLQIQSKPNDDEKSaiAPGDQGAVYATKLLGLSPEALEKALCSRTMRAAGDVYTVPLKK 310
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  430 EQVTCAVGALSKSMYERMFKWLVARINRALDAKLSRQFFIGILDITGFEILEYNSLEQLCINFTNEKLQQFFNWHMFVLE 509
Cdd:cd14903   311 DQAEDCRDALAKAIYSNVFDWLVATINASLGNDAKMANHIGVLDIFGFEHFKHNSFEQFCINYANEKLQQKFTQDVFKTV 390
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  510 QEEYKKESIEWVSIGFgLDLQACIDLIEKPMGILSILEEECMFPKATDLTFKTKLFDNHFGKSVHLQKPKPDKKKFEAHf 589
Cdd:cd14903   391 QIEYEEEGIRWAHIDF-ADNQDVLAVIEDRLGIISLLNDEVMRPKGNEESFVSKLSSIHKDEQDVIEFPRTSRTQFTIK- 468
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  590 elvHYAGVVPYNISGWLEKNKDLLNETVVAVFQKSSNRLLASLFENYMSTDSAIPFGEK----KRKKGA-SFQTVASLHK 664
Cdd:cd14903   469 ---HYAGPVTYESLGFLEKHKDALLPDLSDLMRGSSKPFLRMLFKEKVESPAAASTSLArgarRRRGGAlTTTTVGTQFK 545
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  665 ENLNKLMTNLKSTAPHFVRCINPNVNKIPGILDPYLVLQQLRCNGVLEGTRICREGFPNRLQYADFKQRYCILNPRTFPK 744
Cdd:cd14903   546 DSLNELMTTIRSTNVHYVRCIKPNSIKSPTELDHLMVVSQLRCAGVIEAIRISRAAYPNRLLHEEFLDKFWLFLPEGRNT 625
                         650       660       670
                  ....*....|....*....|....*....|....*
gi 767926067  745 SKFVssRKAAEELLGSLEIDH-TQYRFGITKVFFK 778
Cdd:cd14903   626 DVPV--AERCEALMKKLKLESpEQYQMGLTRIYFQ 658
MYSc_Myo31 cd14892
class XXXI myosin, motor domain; Class XXXI myosins have a very long neck region consisting of ...
117-778 8.14e-159

class XXXI myosin, motor domain; Class XXXI myosins have a very long neck region consisting of 17 IQ motifs and 2 tandem ANK repeats that are separated by a PH domain. The myosin classes XXX to XXXIV contain members from Phytophthora species and Hyaloperonospora parasitica. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276857 [Multi-domain]  Cd Length: 656  Bit Score: 503.14  E-value: 8.14e-159
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  117 ASVLHTLKRRYGQWMIYTYSGLFCVTINPYKWLP-VYQ-KEVMAAYK-GKRRSEAPPHIFAVANNAFQDMLHNR----EN 189
Cdd:cd14892     1 APLLDVLRRRYERDAIYTFTADILISINPYKSIPlLYDvPGFDSQRKeEATASSPPPHVFSIAERAYRAMKGVGkgqgTP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  190 QSILFTGESGAGKTVNSKHIIQYFATIAAMIESRKKQGA-------LEDQIMQANTILEAFGNAKTLRNDNSSRFGKFIR 262
Cdd:cd14892    81 QSIVVSGESGAGKTEASKYIMKYLATASKLAKGASTSKGaanahesIEECVLLSNLILEAFGNAKTIRNDNSSRFGKYIQ 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  263 MHFGARGMLSSVDIDIYLLEKSRVIFQQAGERNYHIFYQILSGQKELHDLLLVSANPSDFHFCSCG-AVTVESLDDAEEL 341
Cdd:cd14892   161 IHYNSDGRIAGASTDHFLLEKSRLVGPDANERNYHIFYQLLAGLDANENAALELTPAESFLFLNQGnCVEVDGVDDATEF 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  342 LATEQAMDILGFLPDEKYGCYKLTGAIMHFGNMKFKQ--KPREEQLEADGTENADKAAFLMGINSSELVKCLIhPRIKVG 419
Cdd:cd14892   241 KQLRDAMEQLGFDAEFQRPIFEVLAAVLHLGNVRFEEnaDDEDVFAQSADGVNVAKAAGLLGVDAAELMFKLV-TQTTST 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  420 neyvTRGQ------TIEQVTCAVGALSKSMYERMFKWLVARINRA----------LDAKLSRQFFIGILDITGFEILEYN 483
Cdd:cd14892   320 ----ARGSvleiklTAREAKNALDALCKYLYGELFDWLISRINAChkqqtsgvtgGAASPTFSPFIGILDIFGFEIMPTN 395
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  484 SLEQLCINFTNEKLQQFFNWHMFVLEQEEYKKESIEWVSIGFGlDLQACIDLIEK-PMGILSILEEECMFP-KATDLTFK 561
Cdd:cd14892   396 SFEQLCINFTNEMLQQQFNKHVFVLEQEVYASEGIDVSAIEFQ-DNQDCLDLIQKkPLGLLPLLEEQMLLKrKTTDKQLL 474
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  562 TKLFDNHFGKSVHLQKPkpdkkKFEA-HFELVHYAGVVPYNISGWLEKNKDLLNETVVAVFQKSSNrllaslfenymstd 640
Cdd:cd14892   475 TIYHQTHLDKHPHYAKP-----RFECdEFVLRHYAGDVTYDVHGFLAKNNDNLHDDLRDLLRSSSK-------------- 535
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  641 saipfgekkrkkgasFQTvaslhkeNLNKLMTNLKSTAPHFVRCINPNVNKIPGILDPYLVLQQLRCNGVLEGTRICREG 720
Cdd:cd14892   536 ---------------FRT-------QLAELMEVLWSTTPSYIKCIKPNNLKFPGGFSCELVRDQLIYSGVLEVVRIRREG 593
                         650       660       670       680       690       700
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767926067  721 FPNRLQYADFKQRYCIL---------NPRTfpKSKFVSSRKAAEELLGSLEIDHTQyrFGITKVFFK 778
Cdd:cd14892   594 FPIRRQFEEFYEKFWPLarnkagvaaSPDA--CDATTARKKCEEIVARALERENFQ--LGRTKVFLR 656
MYSc_Myo9 cd01385
class IX myosin, motor domain; Myosin IX is a processive single-headed motor, which might play ...
117-778 2.18e-156

class IX myosin, motor domain; Myosin IX is a processive single-headed motor, which might play a role in signalling. It has a N-terminal RA domain, an IQ domain, a C1_1 domain, and a RhoGAP domain. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276836 [Multi-domain]  Cd Length: 690  Bit Score: 497.67  E-value: 2.18e-156
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  117 ASVLHTLKRRYGQWMIYTYSGLFCVTINPYKWLPVYQKEVMAAYKGKRRSEAPPHIFAVANNAFQDMLHNRENQSILFTG 196
Cdd:cd01385     1 QTLLENLRARFKHGKIYTYVGSILIAVNPFKFLPIYNPKYVKMYQNRRLGKLPPHIFAIADVAYHAMLRKKKNQCIVISG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  197 ESGAGKTVNSKHIIQYFATIaamieSRKKQGA-LEDQIMQANTILEAFGNAKTLRNDNSSRFGKFIRMHFGARGMLSSVD 275
Cdd:cd01385    81 ESGSGKTESTNFLLHHLTAL-----SQKGYGSgVEQTILGAGPVLEAFGNAKTAHNNNSSRFGKFIQVNYRENGMVRGAV 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  276 IDIYLLEKSRVIFQQAGERNYHIFYQILSGQKELHDLLLVSANPSDFHFCSCGA-VTVESLDDAEELLATEQAMDILGFL 354
Cdd:cd01385   156 VEKYLLEKSRIVSQEKNERNYHVFYYLLAGASEEERKELHLKQPEDYHYLNQSDcYTLEGEDEKYEFERLKQAMEMVGFL 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  355 PDEKYGCYKLTGAIMHFGNMKFKQKP--REEQLEADGTENADKAAFLMGINSSELVKCLIHPRIKVGNEYVTRGQTIEQV 432
Cdd:cd01385   236 PETQRQIFSVLSAVLHLGNIEYKKKAyhRDESVTVGNPEVLDIISELLRVKEETLLEALTTKKTVTVGETLILPYKLPEA 315
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  433 TCAVGALSKSMYERMFKWLVARINRALDAKLS----RQFFIGILDITGFEILEYNSLEQLCINFTNEKLQQFFNWHMFVL 508
Cdd:cd01385   316 IATRDAMAKCLYSALFDWIVLRINHALLNKKDleeaKGLSIGVLDIFGFEDFGNNSFEQFCINYANEHLQYYFNQHIFKL 395
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  509 EQEEYKKESIEWVSIGFgLDLQACIDLIE-KPMGILSILEEECMFPKATDLTFKTKlFDNHFGKSVHLQKPkpdkKKFEA 587
Cdd:cd01385   396 EQEEYKKEGISWHNIEY-TDNTGCLQLISkKPTGLLCLLDEESNFPGATNQTLLAK-FKQQHKDNKYYEKP----QVMEP 469
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  588 HFELVHYAGVVPYNISGWLEKNKDLLNETVVAVFQKSSN------------------------RLLASLFE--------- 634
Cdd:cd01385   470 AFIIAHYAGKVKYQIKDFREKNLDLMRPDIVAVLRSSSSafvreligidpvavfrwavlraffRAMAAFREagrrraqrt 549
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  635 ---NYMSTDSAIPFGEKKRKK------GASFQTvaslhkeNLNKLMTNLKSTAPHFVRCINPNVNKIPGILDPYLVLQQL 705
Cdd:cd01385   550 aghSLTLHDRTTKSLLHLHKKkkppsvSAQFQT-------SLSKLMETLGQAEPFFIRCIKSNAEKKPLRFDDELVLRQL 622
                         650       660       670       680       690       700       710
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767926067  706 RCNGVLEGTRICREGFPNRLQYADFKQRYCILNPRTFPKSKfvSSRKaaeELLGSLEIDHTQYRFGITKVFFK 778
Cdd:cd01385   623 RYTGMLETVRIRRSGYSVRYTFQEFITQFQVLLPKGLISSK--EDIK---DFLEKLNLDRDNYQIGKTKVFLK 690
MYSc_Myo40 cd14901
class XL myosin, motor domain; The class XL myosins are comprised of Stramenopiles. Not much ...
117-776 3.65e-156

class XL myosin, motor domain; The class XL myosins are comprised of Stramenopiles. Not much is known about this myosin class. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276866 [Multi-domain]  Cd Length: 655  Bit Score: 495.85  E-value: 3.65e-156
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  117 ASVLHTLKRRYGQWMIYTYSGLFCVTINPYKWLPVYQKEVMAAY------KGKRRSEAPPHIFAVANNAFQDMLHNRE-- 188
Cdd:cd14901     1 PSILHVLRRRFAHGLIYTSTGAILVAINPFRRLPLYDDETKEAYyehgerRAAGERKLPPHVYAVADKAFRAMLFASRgq 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  189 --NQSILFTGESGAGKTVNSKHIIQYFATIAamieSRKKQGA-------LEDQIMQANTILEAFGNAKTLRNDNSSRFGK 259
Cdd:cd14901    81 kcDQSILVSGESGAGKTETTKIIMNYLASVS----SATTHGQnaterenVRDRVLESNPILEAFGNARTNRNNNSSRFGK 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  260 FIRMHFGARGMLSSVDIDIYLLEKSRVIFQQAGERNYHIFYQILSG--QKELHDLLLVSANPSDFHFCSCGAVTVESLDD 337
Cdd:cd14901   157 FIRLGFASSGSLLGASISTYLLERVRLVSQAKGERNYHIFYELLRGasSDELHALGLTHVEEYKYLNSSQCYDRRDGVDD 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  338 AEELLATEQAMDILGFLPDEKYGCYKLTGAIMHFGNMKFKQKPRE-EQLEADGTENADKAAFLMGINSSELVKCLIHPRI 416
Cdd:cd14901   237 SVQYAKTRHAMTTIGMSPDEQISVLQLVAAVLHLGNLCFVKKDGEgGTFSMSSLANVRAACDLLGLDMDVLEKTLCTREI 316
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  417 KVGNEYVTRGQTIEQVTCAVGALSKSMYERMFKWLVARINRALDAKLS--RQFFIGILDITGFEILEYNSLEQLCINFTN 494
Cdd:cd14901   317 RAGGEYITMPLSVEQALLTRDVVAKTLYAQLFDWLVDRINESIAYSEStgASRFIGIVDIFGFEIFATNSLEQLCINFAN 396
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  495 EKLQQFFNWHMFVLEQEEYKKESIEWVSIGFGlDLQACIDLIE-KPMGILSILEEECMFPKATDLTFKTKLFDNhFGKSV 573
Cdd:cd14901   397 EKLQQLFGKFVFEMEQDEYVAEAIPWTFVEYP-NNDACVAMFEaRPTGLFSLLDEQCLLPRGNDEKLANKYYDL-LAKHA 474
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  574 HLQKPKPDKKKfeAHFELVHYAGVVPYNISGWLEKNKDLLNETVVAVFQKSSNRLLASlfenymstdsaipfgekkrkkg 653
Cdd:cd14901   475 SFSVSKLQQGK--RQFVIHHYAGAVCYATDGFCDKNKDHVHSEALALLRTSSNAFLSS---------------------- 530
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  654 asfqTVASLHKENLNKLMTNLKSTAPHFVRCINPNVNKIPGILDPYLVLQQLRCNGVLEGTRICREGFPNRLQYADFKQR 733
Cdd:cd14901   531 ----TVVAKFKVQLSSLLEVLNATEPHFIRCIKPNDVLSPSEFDAKRVLEQLRCSGVLEAVKISRSGYPVRFPHDAFVHT 606
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|....*....
gi 767926067  734 YCILNPRTfpKSKFVSSRKAAEELLGSLEI------DHTQYRFGITKVF 776
Cdd:cd14901   607 YSCLAPDG--ASDTWKVNELAERLMSQLQHselnieHLPPFQVGKTKVF 653
MYSc_Myo15 cd01387
class XV mammal-like myosin, motor domain; The class XV myosins are monomeric. In vertebrates, ...
117-778 2.10e-154

class XV mammal-like myosin, motor domain; The class XV myosins are monomeric. In vertebrates, myosin XV appears to be expressed in sensory tissue and play a role in hearing. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. C-terminal to the head domain are 2 MyTH4 domain, a FERM domain, and a SH3 domain. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276838 [Multi-domain]  Cd Length: 657  Bit Score: 491.19  E-value: 2.10e-154
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  117 ASVLHTLKRRYGQWMIYTYSGLFCVTINPYKWLPVYQKEVMAAYKGKRRSEAPPHIFAVANNAFQDMLHNRENQSILFTG 196
Cdd:cd01387     1 TTVLWNLKTRYERNLIYTYIGSILVSVNPYKMFDIYGLEQVQQYSGRALGELPPHLFAIANLAFAKMLDAKQNQCVVISG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  197 ESGAGKTVNSKHIIQYFATIAamiesrKKQGAL-EDQIMQANTILEAFGNAKTLRNDNSSRFGKFIRMHFgARGMLSSVD 275
Cdd:cd01387    81 ESGSGKTEATKLIMQYLAAVN------QRRNNLvTEQILEATPLLEAFGNAKTVRNDNSSRFGKYLEVFF-EGGVIVGAI 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  276 IDIYLLEKSRVIFQQAGERNYHIFYQILSG----QKELHDLLlvsaNPSDFHFC----SCGAVTVESLDDAEELLAteqA 347
Cdd:cd01387   154 TSQYLLEKSRIVTQAKNERNYHVFYELLAGlpaqLRQKYGLQ----EAEKYFYLnqggNCEIAGKSDADDFRRLLA---A 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  348 MDILGFLPDEKYGCYKLTGAIMHFGNMKFKQKPRE---EQLEADGTENADKAAFLMGINSSELVKCLIHPRIKVGNEYVT 424
Cdd:cd01387   227 MQVLGFSSEEQDSIFRILASVLHLGNVYFHKRQLRhgqEGVSVGSDAEIQWVAHLLQISPEGLQKALTFKVTETRRERIF 306
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  425 RGQTIEQVTCAVGALSKSMYERMFKWLVARINRALDAKLSRQFFIGILDITGFEILEYNSLEQLCINFTNEKLQQFFNWH 504
Cdd:cd01387   307 TPLTIDQALDARDAIAKALYALLFSWLVTRVNAIVYSGTQDTLSIAILDIFGFEDLSENSFEQLCINYANENLQYYFNKH 386
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  505 MFVLEQEEYKKESIEWVSIGFgLDLQACIDLI-EKPMGILSILEEECMFPKATDLTFKTKLFDNHfGKSVHLQKPKPDkk 583
Cdd:cd01387   387 VFKLEQEEYIREQIDWTEIAF-ADNQPVINLIsKKPVGILHILDDECNFPQATDHSFLEKCHYHH-ALNELYSKPRMP-- 462
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  584 kfEAHFELVHYAGVVPYNISGWLEKNKDLLNETVVAVFQKSSNRLLASLFENYMS-TDSAIPFGEKKRKKGASFQ--TVA 660
Cdd:cd01387   463 --LPEFTIKHYAGQVWYQVHGFLDKNRDQLRQDVLELLVSSRTRVVAHLFSSHRAqTDKAPPRLGKGRFVTMKPRtpTVA 540
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  661 SLHKENLNKLMTNLKSTAPHFVRCINPNVNKIPGILDPYLVLQQLRCNGVLEGTRICREGFPNRLQYADFKQRYCILNPR 740
Cdd:cd01387   541 ARFQDSLLQLLEKMERCNPWFVRCLKPNHKKEPMLFDMDVVMAQLRYSGMLETIRIRKEGYPVRLPFQVFIDRYRCLVAL 620
                         650       660       670
                  ....*....|....*....|....*....|....*....
gi 767926067  741 TFPKS-KFVSSRKAAEELLGSLEIDhtQYRFGITKVFFK 778
Cdd:cd01387   621 KLPRPaPGDMCVSLLSRLCTVTPKD--MYRLGATKVFLR 657
MYSc_Myo29 cd14890
class XXIX myosin, motor domain; Class XXIX myosins are comprised of Stramenopiles and have ...
117-778 1.26e-153

class XXIX myosin, motor domain; Class XXIX myosins are comprised of Stramenopiles and have very long tail domains consisting of three IQ motifs, short coiled-coil regions, up to 18 CBS domains, a PB1 domain, and a carboxy-terminal transmembrane domain. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276855 [Multi-domain]  Cd Length: 662  Bit Score: 489.29  E-value: 1.26e-153
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  117 ASVLHTLKRRYGQWMIYTYSGLFCVTINPYKWLP-VYQKEVMAAYKGKRRSEAPPHIFAVANNAF----QDMLHNRENQS 191
Cdd:cd14890     1 ASLLHTLRLRYERDEIYTYVGPILISINPYKSIPdLYSEERMLLYHGTTAGELPPHVFAIADHAYtqliQSGVLDPSNQS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  192 ILFTGESGAGKTVNSKHIIQYFATI-------------AAMIESRKKQGALEDQIMQANTILEAFGNAKTLRNDNSSRFG 258
Cdd:cd14890    81 IIISGESGAGKTEATKIIMQYLARItsgfaqgasgegeAASEAIEQTLGSLEDRVLSSNPLLESFGNAKTLRNDNSSRFG 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  259 KFIRMHFGARGMLSSVDIDIYLLEKSRVIFQQAGERNYHIFYQILSGQKE--LHDLLLVSANPSDFHFCSCGAVtvESLD 336
Cdd:cd14890   161 KFIEIQFDHHGKIVGAEISNFLLEKTRIVTQNDGERNYHIFYQLLAGADEalRERLKLQTPVEYFYLRGECSSI--PSCD 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  337 DAEELLATEQAMDILGFLPDEKYGCYKLTGAIMHFGNMKFKQKPREEQLEADGT-ENADKAAFLMGINSSELVKCLIHPR 415
Cdd:cd14890   239 DAKAFAETIRCLSTIGISEENQDAVFGLLAAVLHLGNVDFESENDTTVLEDATTlQSLKLAAELLGVNEDALEKALLTRQ 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  416 IKVGNEYVTRGQTIEQVTCAVGALSKSMYERMFKWLVARINRALDAKLSRQFFIGILDITGFEILEYNSLEQLCINFTNE 495
Cdd:cd14890   319 LFVGGKTIVQPQNVEQARDKRDALAKALYSSLFLWLVSELNRTISSPDDKWGFIGVLDIYGFEKFEWNTFEQLCINYANE 398
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  496 KLQQFFNWHMFVLEQEEYKKESIEWVSIGFGlDLQACIDLIE-KPMGILSILE--EEC--MFPKATDLTFKTKLFDNHFG 570
Cdd:cd14890   399 KLQRHFNQHMFEVEQVEYSNEGIDWQYITFN-DNQACLELIEgKVNGKPGIFItlDDCwrFKGEEANKKFVSQLHASFGR 477
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  571 KSV------------HLQKPKPDKKKfeaHFELVHYAGVVPYNISGWLEKNKDLLNETVVAVFQKSSNRLlaslfenyms 638
Cdd:cd14890   478 KSGsggtrrgssqhpHFVHPKFDADK---QFGIKHYAGDVIYDASGFNEKNNETLNAEMKELIKQSRRSI---------- 544
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  639 tdsaipfgekkrkKGASfqtVASLHKENLNKLMTNLKSTAPHFVRCINPNVNKIPGILDPYLVLQQLRCNGVLEGTRICR 718
Cdd:cd14890   545 -------------REVS---VGAQFRTQLQELMAKISLTNPRYVRCIKPNETKAPGKFDGLDCLRQLKYSGMMEAIQIRQ 608
                         650       660       670       680       690       700
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  719 EGFPNRLQYADFKQRYCILNPRTFPKSKFVssrkaaEELLGSLEIDHTQYRFGITKVFFK 778
Cdd:cd14890   609 QGFALREEHDSFFYDFQVLLPTAENIEQLV------AVLSKMLGLGKADWQIGSSKIFLK 662
MYSc_Myo10 cd14873
class X myosin, motor domain; Myosin X is an unconventional myosin motor that functions as a ...
117-778 1.07e-149

class X myosin, motor domain; Myosin X is an unconventional myosin motor that functions as a monomer. In mammalian cells, the motor is found to localize to filopodia. Myosin X walks towards the barbed ends of filaments and is thought to walk on bundles of actin, rather than single filaments, a unique behavior. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. C-terminal to the head domain are a variable number of IQ domains, 2 PH domains, a MyTH4 domain, and a FERM domain. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276840 [Multi-domain]  Cd Length: 651  Bit Score: 478.14  E-value: 1.07e-149
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  117 ASVLHTLKRRYGQWMIYTYSGLFCVTINPYKWLP-VYQKEVMAAYKGKRRSEAPPHIFAVANNAFQDMLHNRENQSILFT 195
Cdd:cd14873     1 GSIMYNLFQRYKRNQIYTYIGSILASVNPYQPIAgLYEPATMEQYSRRHLGELPPHIFAIANECYRCLWKRHDNQCILIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  196 GESGAGKTVNSKHIIQYFATIAAMI---ESRKKQGALEDQIMQANTILEAFGNAKTLRNDNSSRFGKFIRMHFGARGMLS 272
Cdd:cd14873    81 GESGAGKTESTKLILKFLSVISQQSlelSLKEKTSCVEQAILESSPIMEAFGNAKTVYNNNSSRFGKFVQLNICQKGNIQ 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  273 SVDIDIYLLEKSRVIFQQAGERNYHIFYQILSGQKELHDLLLVSANPSDFHFCS-CGAVTVESLDDAEELLATEQAMDIL 351
Cdd:cd14873   161 GGRIVDYLLEKNRVVRQNPGERNYHIFYALLAGLEHEEREEFYLSTPENYHYLNqSGCVEDKTISDQESFREVITAMEVM 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  352 GFLPDEKYGCYKLTGAIMHFGNMKFkqkpreeqLEADGTENADKAAF-----LMGINSSELVKCLIHPRIKVGNEYVTRG 426
Cdd:cd14873   241 QFSKEEVREVSRLLAGILHLGNIEF--------ITAGGAQVSFKTALgrsaeLLGLDPTQLTDALTQRSMFLRGEEILTP 312
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  427 QTIEQVTCAVGALSKSMYERMFKWLVARINRALDAKLSRQfFIGILDITGFEILEYNSLEQLCINFTNEKLQQFFNWHMF 506
Cdd:cd14873   313 LNVQQAVDSRDSLAMALYARCFEWVIKKINSRIKGKEDFK-SIGILDIFGFENFEVNHFEQFNINYANEKLQEYFNKHIF 391
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  507 VLEQEEYKKESIEWVSIGFgLDLQACIDLIEKPMGILSILEEECMFPKATDLTFKTKLfdnhfgKSVHLQKPKPDKKKFE 586
Cdd:cd14873   392 SLEQLEYSREGLVWEDIDW-IDNGECLDLIEKKLGLLALINEESHFPQATDSTLLEKL------HSQHANNHFYVKPRVA 464
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  587 AH-FELVHYAGVVPYNISGWLEKNKDLLNETVVAVFQKSSNRLLASLFENYMSTDSA-IPFGEKKRKKgasfQTVASLHK 664
Cdd:cd14873   465 VNnFGVKHYAGEVQYDVRGILEKNRDTFRDDLLNLLRESRFDFIYDLFEHVSSRNNQdTLKCGSKHRR----PTVSSQFK 540
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  665 ENLNKLMTNLKSTAPHFVRCINPNVNKIPGILDPYLVLQQLRCNGVLEGTRICREGFPNRLQYADFKQRYCILNPRTfpk 744
Cdd:cd14873   541 DSLHSLMATLSSSNPFFVRCIKPNMQKMPDQFDQAVVLNQLRYSGMLETVRIRKAGYAVRRPFQDFYKRYKVLMRNL--- 617
                         650       660       670
                  ....*....|....*....|....*....|....
gi 767926067  745 SKFVSSRKAAEELLGSLEIDHTQYRFGITKVFFK 778
Cdd:cd14873   618 ALPEDVRGKCTSLLQLYDASNSEWQLGKTKVFLR 651
MYSc_Myo36 cd14897
class XXXVI myosin, motor domain; This class of molluscan myosins contains a motor domain ...
117-778 4.06e-147

class XXXVI myosin, motor domain; This class of molluscan myosins contains a motor domain followed by a GlcAT-I (Beta1,3-glucuronyltransferase I) domain. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276862 [Multi-domain]  Cd Length: 635  Bit Score: 470.33  E-value: 4.06e-147
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  117 ASVLHTLKRRYGQWMIYTYSGLFCVTINPYKWLPVYQKEVMAAYKGKR-RSEAPPHIFAVANNAFQDMLHNRENQSILFT 195
Cdd:cd14897     1 NTIVQTLKSRYNKDKFYTYIGDILVAVNPCKPLPIFDKKHHEEYSNLSvRSQRPPHLFWIADQAYRRLLETGRNQCILVS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  196 GESGAGKTVNSKHIIQYFATIaamieSRKKQGALEDQIMQANTILEAFGNAKTLRNDNSSRFGKFIRMHFGARGMLSSVD 275
Cdd:cd14897    81 GESGAGKTESTKYMIKHLMKL-----SPSDDSDLLDKIVQINPLLEAFGNASTVMNDNSSRFGKFIELHFTENGQLLGAK 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  276 IDIYLLEKSRVIFQQAGERNYHIFYQILSGQKELHDLLLVSANPSDFHFCSCGAVTVESLDDAEELLATEQA-------M 348
Cdd:cd14897   156 IDDYLLEKSRVVHRGNGEKNFHIFYALFAGMSRDRLLYYFLEDPDCHRILRDDNRNRPVFNDSEELEYYRQMfhdltniM 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  349 DILGFLPDEKYGCYKLTGAIMHFGNMKFkqkprEEQLEADGTENADK-----AAFLMGINSSELVKCLIHPRIKVGNEYV 423
Cdd:cd14897   236 KLIGFSEEDISVIFTILAAILHLTNIVF-----IPDEDTDGVTVADEyplhaVAKLLGIDEVELTEALISNVNTIRGERI 310
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  424 TRGQTIEQVTCAVGALSKSMYERMFKWLVARINRALDAK-----LSRQFFIGILDITGFEILEYNSLEQLCINFTNEKLQ 498
Cdd:cd14897   311 QSWKSLRQANDSRDALAKDLYSRLFGWIVGQINRNLWPDkdfqiMTRGPSIGILDMSGFENFKINSFDQLCINLSNERLQ 390
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  499 QFFNWHMFVLEQEEYKKESIEWVSIGFGlDLQACIDLI-EKPMGILSILEEECMFPKATDLTFKTKLfDNHFGKSVHLQK 577
Cdd:cd14897   391 QYFNDYVFPRERSEYEIEGIEWRDIEYH-DNDDVLELFfKKPLGILPLLDEESTFPQSTDSSLVQKL-NKYCGESPRYVA 468
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  578 PKPDKKKFEAHfelvHYAGVVPYNISGWLEKNKDLLNETVVAVFQKSSNRLLASLFENYMstdsaipfgekkrkkgasfq 657
Cdd:cd14897   469 SPGNRVAFGIR----HYAEQVTYDADGFLEKNRDNLSSDIVGCLLNSNNEFISDLFTSYF-------------------- 524
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  658 tvaslhKENLNKLMTNLKSTAPHFVRCINPNVNKIPGILDPYLVLQQLRCNGVLEGTRICREGFPNRLQYADFKQRYCIL 737
Cdd:cd14897   525 ------KRSLSDLMTKLNSADPLFVRCIKPNNFLRPNKFDDELVRRQLLCNGLMEIAKIRRDGYPIRIKYEDFVKRYKEI 598
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|.
gi 767926067  738 NPrtFPKSKFVSSRKAAEELLGSLEIDhtQYRFGITKVFFK 778
Cdd:cd14897   599 CD--FSNKVRSDDLGKCQKILKTAGIK--GYQFGKTKVFLK 635
MYSc_Myo28 cd14889
class XXVIII myosin, motor domain; These myosins are found in fish, chicken, and mollusks. The ...
119-778 9.29e-144

class XXVIII myosin, motor domain; These myosins are found in fish, chicken, and mollusks. The tail regions of these class-XXVIII myosins consist of an IQ motif, a short coiled-coil region, and an SH2 domain. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276854  Cd Length: 659  Bit Score: 462.07  E-value: 9.29e-144
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  119 VLHTLKRRYGQWMIYTYSGLFCVTINPYKWLPVYQKEVMAAYKGKRRSEAPPHIFAVANNAFQDML----HNRENQSILF 194
Cdd:cd14889     3 LLEVLKVRFMQSNIYTYVGDILVAINPFKYLHIYEKEVSQKYKCEKKSSLPPHIFAVADRAYQSMLgrlaRGPKNQCIVI 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  195 TGESGAGKTVNSKHIIQYfatiaaMIESRKKQGALEDQIMQANTILEAFGNAKTLRNDNSSRFGKFIRMHFgARGMLSSV 274
Cdd:cd14889    83 SGESGAGKTESTKLLLRQ------IMELCRGNSQLEQQILQVNPLLEAFGNAQTVMNDNSSRFGKYIQLRF-RNGHVKGA 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  275 DIDIYLLEKSRVIFQQAGERNYHIFYQILSG----QKELHDLLlvsaNPSDFHFCSCGAVTVESLD----DAEELLateQ 346
Cdd:cd14889   156 KINEYLLEKSRVVHQDGGEENFHIFYYMFAGisaeDRENYGLL----DPGKYRYLNNGAGCKREVQywkkKYDEVC---N 228
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  347 AMDILGFLPDEKYGCYKLTGAIMHFGNMKFKQkpreEQLEADGTENADK-----AAFLMGINSSELVKCLIHPRIKVGNE 421
Cdd:cd14889   229 AMDMVGFTEQEEVDMFTILAGILSLGNITFEM----DDDEALKVENDSNgwlkaAAGQFGVSEEDLLKTLTCTVTFTRGE 304
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  422 YVTRGQTIEQVTCAVGALSKSMYERMFKWLVARINRALDAKLSRQF---FIGILDITGFEILEYNSLEQLCINFTNEKLQ 498
Cdd:cd14889   305 QIQRHHTKQQAEDARDSIAKVAYGRVFGWIVSKINQLLAPKDDSSVelrEIGILDIFGFENFAVNRFEQACINLANEQLQ 384
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  499 QFFNWHMFVLEQEEYKKESIEWVSIGFgLDLQACIDL-IEKPMGILSILEEECMFPKATDLTFKTKLfDNHFGKSVHLQK 577
Cdd:cd14889   385 YFFNHHIFLMEQKEYKKEGIDWKEITY-KDNKPILDLfLNKPIGILSLLDEQSHFPQATDESFVDKL-NIHFKGNSYYGK 462
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  578 PKPDKKKfeahFELVHYAGVVPYNISGWLEKNKDLLNETVVAVFQKSSNRLLASLFENYMS-TDSAIPFGEKKRKKGASF 656
Cdd:cd14889   463 SRSKSPK----FTVNHYAGKVTYNASGFLEKNRDTIPASIRTLFINSATPLLSVLFTATRSrTGTLMPRAKLPQAGSDNF 538
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  657 -----QTVASLHKENLNKLMTNLKSTAPHFVRCINPNVNKIPGILDPYLVLQQLRCNGVLEGTRICREGFPNRLQYADFK 731
Cdd:cd14889   539 nstrkQSVGAQFKHSLGVLMEKMFAASPHFVRCIKPNHVKVPGQLDSKYIQDQLRYNGLLETIRIRREGFSWRPSFAEFA 618
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|....*..
gi 767926067  732 QRYCILnprtFPKSKFVSSRKAAEELLGSLEIdhTQYRFGITKVFFK 778
Cdd:cd14889   619 ERYKIL----LCEPALPGTKQSCLRILKATKL--VGWKCGKTRLFFK 659
MYSc_Myo39 cd14900
class XXXIX myosin, motor domain; The class XXXIX myosins are found in Stramenopiles. Not much ...
118-737 4.42e-137

class XXXIX myosin, motor domain; The class XXXIX myosins are found in Stramenopiles. Not much is known about this myosin class. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276865  Cd Length: 627  Bit Score: 442.05  E-value: 4.42e-137
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  118 SVLHTLKRRYGQWMIYTYSGLFCVTINPYKWLP-VYQKEVMAAY-----------KGKRRSEAPPHIFAVANNAFQDMLH 185
Cdd:cd14900     2 TILSALETRFYAQKIYTNTGAILLAVNPFQKLPgLYSSDTMAKYllsfearssstRNKGSDPMPPHIYQVAGEAYKAMML 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  186 NR----ENQSILFTGESGAGKTVNSKHIIQYFATI-----AAMIESRKKQGALEDQIMQANTILEAFGNAKTLRNDNSSR 256
Cdd:cd14900    82 GLngvmSDQSILVSGESGSGKTESTKFLMEYLAQAgdnnlAASVSMGKSTSGIAAKVLQTNILLESFGNARTLRNDNSSR 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  257 FGKFIRMHFGARGMLSSVDIDIYLLEKSRVIFQQAGERNYHIFYQILSGQKELHdlllvsanpsdfhfcscgavtvESLD 336
Cdd:cd14900   162 FGKFIKLHFTSGGRLTGASIQTYLLEKVRLVSQSKGERNYHIFYEMAIGASEAA----------------------RKRD 219
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  337 DAEELLAteqAMDILGFLPDEKYGCYKLTGAIMHFGNMKFKQKPREEQLEADGTENA-------DKAAFLMGINSSELVK 409
Cdd:cd14900   220 MYRRVMD---AMDIIGFTPHERAGIFDLLAALLHIGNLTFEHDENSDRLGQLKSDLApssiwsrDAAATLLSVDATKLEK 296
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  410 CLIHPRIKVGNEYVTRGQTIEQVTCAVGALSKSMYERMFKWLVARINRAL---DAKLSRQ--FFIGILDITGFEILEYNS 484
Cdd:cd14900   297 ALSVRRIRAGTDFVSMKLSAAQANNARDALAKALYGRLFDWLVGKMNAFLkmdDSSKSHGglHFIGILDIFGFEVFPKNS 376
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  485 LEQLCINFTNEKLQQFFNWHMFVLEQEEYKKESIEWVSIGFGlDLQACIDLI-EKPMGILSILEEECMFPKATDLTFKTK 563
Cdd:cd14900   377 FEQLCINFANETLQQQFNDYVFKAEQREYESQGVDWKYVEFC-DNQDCVNLIsQRPTGILSLIDEECVMPKGSDTTLASK 455
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  564 LFdNHFGKSVHLQKPKPDKKKfeAHFELVHYAGVVPYNISGWLEKNKDLLNETVVAVFQkssnrllaslfenymstdsai 643
Cdd:cd14900   456 LY-RACGSHPRFSASRIQRAR--GLFTIVHYAGHVEYSTDGFLEKNKDVLHQEAVDLFV--------------------- 511
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  644 pfgekkrkKGASFqtvaslhKENLNKLMTNLKSTAPHFVRCINPNVNKIPGILDPYLVLQQLRCNGVLEGTRICREGFPN 723
Cdd:cd14900   512 --------YGLQF-------KEQLTTLLETLQQTNPHYVRCLKPNDLCKAGIYERERVLNQLRCNGVMEAVRVARAGFPI 576
                         650
                  ....*....|....
gi 767926067  724 RLQYADFKQRYCIL 737
Cdd:cd14900   577 RLLHDEFVARYFSL 590
MYSc_Myo41 cd14902
class XLI myosin, motor domain; The class XLI myosins are comprised of Stramenopiles. Not much ...
117-757 6.76e-136

class XLI myosin, motor domain; The class XLI myosins are comprised of Stramenopiles. Not much is known about this myosin class. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276867 [Multi-domain]  Cd Length: 716  Bit Score: 442.02  E-value: 6.76e-136
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  117 ASVLHTLKRRYGQWMIYTYSGLFCVTINPYKWLP-VYQKEVMAAYK--------GKRRSEAPPHIFAVANNAFQDMLHN- 186
Cdd:cd14902     1 AALLQALSERFEHDQIYTSIGDILVALNPLKPLPdLYSESQLNAYKasmtstspVSQLSELPPHVFAIGGKAFGGLLKPe 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  187 RENQSILFTGESGAGKTVNSKHIIQYFATIAAMIESRKKQGA----LEDQIMQANTILEAFGNAKTLRNDNSSRFGKFIR 262
Cdd:cd14902    81 RRNQSILVSGESGSGKTESTKFLMQFLTSVGRDQSSTEQEGSdaveIGKRILQTNPILESFGNAQTIRNDNSSRFGKFIK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  263 MHFGARGMLSSVDIDIYLLEKSRVIFQQAGERNYHIFYQILSG-QKELHDLLLVSAN----PSDFHFCSCGAVTVESLDD 337
Cdd:cd14902   161 IQFGANNEIVGAQIVSYLLEKVRLLHQSPEERSFHIFYELLEGaDKTLLDLLGLQKGgkyeLLNSYGPSFARKRAVADKY 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  338 AEELLATEQAMDILGFLPDEKYGCYKLTGAIMHFGNMKFK---QKPREEQLEADGTENADKAAFLMGINSSELVKCLIHP 414
Cdd:cd14902   241 AQLYVETVRAFEDTGVGELERLDIFKILAALLHLGNVNFTaenGQEDATAVTAASRFHLAKCAELMGVDVDKLETLLSSR 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  415 RIKVGNEYVTRGQTIEQVTCAVGALSKSMYERMFKWLVARINRALDAKLSRQFF---------IGILDITGFEILEYNSL 485
Cdd:cd14902   321 EIKAGVEVMVLKLTPEQAKEICGSLAKAIYGRLFTWLVRRLSDEINYFDSAVSIsdedeelatIGILDIFGFESLNRNGF 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  486 EQLCINFTNEKLQQFFNWHMFVLEQEEYKKESIEWVSIGFGlDLQACIDLIE-KPMGILSILEEECMFPKATDLTFKTKL 564
Cdd:cd14902   401 EQLCINYANERLQAQFNEFVFVKEQQIYIAEGIDWKNISYP-SNAACLALFDdKSNGLFSLLDQECLMPKGSNQALSTKF 479
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  565 FDNHFGksvhlqkpkpdkkkfEAHFELVHYAGVVPYNISGWLEKNKDLLNETVVAVFQKSSNRLLASLFENYMSTDSAIP 644
Cdd:cd14902   480 YRYHGG---------------LGQFVVHHFAGRVCYNVEQFVEKNTDALPADASDILSSSSNEVVVAIGADENRDSPGAD 544
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  645 FGEKKRKKGASFQT--VASLHKENLNKLMTNLKSTAPHFVRCINPNVNKIPGILDPYLVLQQLRCNGVLEGTRICREGFP 722
Cdd:cd14902   545 NGAAGRRRYSMLRApsVSAQFKSQLDRLIVQIGRTEAHYVRCLKPNEVKKPGIFDRERMVEQMRSVGVLEAVRIARHGYS 624
                         650       660       670
                  ....*....|....*....|....*....|....*
gi 767926067  723 NRLQYADFKQRYCILNPrtFPKSKFVSSRKAAEEL 757
Cdd:cd14902   625 VRLAHASFIELFSGFKC--FLSTRDRAAKMNNHDL 657
MYSc_Myo43 cd14904
class XLIII myosin, motor domain; The class XLIII myosins are comprised of Stramenopiles. Not ...
117-778 3.29e-131

class XLIII myosin, motor domain; The class XLIII myosins are comprised of Stramenopiles. Not much is known about this myosin class. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276869  Cd Length: 653  Bit Score: 426.67  E-value: 3.29e-131
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  117 ASVLHTLKRRYGQWMIYTYSGLFCVTINPYKWLP-VYQKEVMAAYKGKRRSEAPPHIFAVANNAFQDMLHNRENQSILFT 195
Cdd:cd14904     1 PSILFNLKKRFAASKPYTYTNDIVIALNPYKWIDnLYGDHLHEQYLKKPRDKLQPHVYATSTAAYKHMLTNEMNQSILVS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  196 GESGAGKTVNSKHIIQYFATIAAmieSRKKQGAleDQIMQANTILEAFGNAKTLRNDNSSRFGKFIRMHFGARGMLSSVD 275
Cdd:cd14904    81 GESGAGKTETTKIVMNHLASVAG---GRKDKTI--AKVIDVNPLLESFGNAKTTRNDNSSRFGKFTQLQFDGRGKLIGAK 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  276 IDIYLLEKSRVIFQQAGERNYHIFYQILSG--QKELHDLLLVSANPSDFHFCSCGAVTVESLDDAEELLATEQAMDILGF 353
Cdd:cd14904   156 CETYLLEKSRVVSIAEGERNYHIFYQLLAGlsSEERKEFGLDPNCQYQYLGDSLAQMQIPGLDDAKLFASTQKSLSLIGL 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  354 LPDEKYGCYKLTGAIMHFGNMKFKQKPREEQLEADGtENADKAAFLMGINSSELVKCLIHPRIKVGNEYVTRGQTIEQVT 433
Cdd:cd14904   236 DNDAQRTLFKILSGVLHLGEVMFDKSDENGSRISNG-SQLSQVAKMLGLPTTRIEEALCNRSVVTRNESVTVPLAPVEAE 314
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  434 CAVGALSKSMYERMFKWLVARINRAL---DAKLSRQffIGILDITGFEILEYNSLEQLCINFTNEKLQQFFNWHMFVLEQ 510
Cdd:cd14904   315 ENRDALAKAIYSKLFDWMVVKINAAIstdDDRIKGQ--IGVLDIFGFEDFAHNGFEQFCINYANEKLQQKFTTDVFKTVE 392
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  511 EEYKKESIEWVSIGFGlDLQACIDLIEKPMGILSILEEECMFPKATDLTFKTKLFDNH--FGKSVHLQKPKPDKKKFEAH 588
Cdd:cd14904   393 EEYIREGLQWDHIEYQ-DNQGIVEVIDGKMGIIALMNDHLRQPRGTEEALVNKIRTNHqtKKDNESIDFPKVKRTQFIIN 471
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  589 felvHYAGVVPYNISGWLEKNKDLLNETVVAVFQKSSNRLLASLFENYMSTDSAIpfGEKKRKKGASFQTVASLHKENLN 668
Cdd:cd14904   472 ----HYAGPVTYETVGFMEKHRDTLQNDLLDLVLLSSLDLLTELFGSSEAPSETK--EGKSGKGTKAPKSLGSQFKTSLS 545
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  669 KLMTNLKSTAPHFVRCINPNVNKIPGILDPYLVLQQLRCNGVLEGTRICREGFPNRLQYADFKQRYCILnprtFPKSKFV 748
Cdd:cd14904   546 QLMDNIKTTNTHYVRCIKPNANKSPTEFDKRMVVEQLRSAGVIEAIRITRSGYPSRLTPKELATRYAIM----FPPSMHS 621
                         650       660       670
                  ....*....|....*....|....*....|..
gi 767926067  749 -SSRKAAEELLGSL-EIDHTQYRFGITKVFFK 778
Cdd:cd14904   622 kDVRRTCSVFMTAIgRKSPLEYQIGKSLIYFK 653
MYSc_Myo46 cd14907
class XLVI myosin, motor domain; The class XLVI myosins are comprised of Alveolata. Not much ...
117-746 7.31e-131

class XLVI myosin, motor domain; The class XLVI myosins are comprised of Alveolata. Not much is known about this myosin class. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276872 [Multi-domain]  Cd Length: 669  Bit Score: 426.37  E-value: 7.31e-131
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  117 ASVLHTLKRRYGQWMIYTYSGLFCVTINPYKWLP-VYQKEVMAAYKGK--------RRSEAPPHIFAVANNAFQDMLHNR 187
Cdd:cd14907     1 AELLINLKKRYQQDKIFTYVGPTLIVMNPYKQIDnLFSEEVMQMYKEQiiqngeyfDIKKEPPHIYAIAALAFKQLFENN 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  188 ENQSILFTGESGAGKTVNSKHIIQYFATIAA--------------MIESRKKQGALEDQIMQANTILEAFGNAKTLRNDN 253
Cdd:cd14907    81 KKQAIVISGESGAGKTENAKYAMKFLTQLSQqeqnseevltltssIRATSKSTKSIEQKILSCNPILEAFGNAKTVRNDN 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  254 SSRFGKFIRMHFGAR-GMLSSVDIDIYLLEKSRVIFQQAGERNYHIFYQILSG--QKELHDLLLVSANPSDFHFC--SCG 328
Cdd:cd14907   161 SSRFGKYVSILVDKKkRKILGARIQNYLLEKSRVTQQGQGERNYHIFYHLLYGadQQLLQQLGLKNQLSGDRYDYlkKSN 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  329 AVTVESLDDAEELLATEQAMDILGFLPDEKYGCYKLTGAIMHFGNMKFKQKP--REEQLEADGTENADKAAFLMGINSSE 406
Cdd:cd14907   241 CYEVDTINDEKLFKEVQQSFQTLGFTEEEQDSIWRILAAILLLGNLQFDDSTldDNSPCCVKNKETLQIIAKLLGIDEEE 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  407 LVKCLIHPRIKVGNEYVTRGQTIEQVTCAVGALSKSMYERMFKWLVARINRAL--------DAKLSRQFFIGILDITGFE 478
Cdd:cd14907   321 LKEALTTKIRKVGNQVITSPLSKKECINNRDSLSKELYDRLFNWLVERLNDTImpkdekdqQLFQNKYLSIGLLDIFGFE 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  479 ILEYNSLEQLCINFTNEKLQQFFNWHMFVLEQEEYKKESIE-WVS-IGFgLDLQACIDLIEK-PMGILSILEEECMFPKA 555
Cdd:cd14907   401 VFQNNSFEQLCINYTNEKLQQLYISYVFKAEEQEFKEEGLEdYLNqLSY-TDNQDVIDLLDKpPIGIFNLLDDSCKLATG 479
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  556 TDLTFKTKLFDNHFGKSVHLQKPKPDKKKFEahfeLVHYAGVVPYNISGWLEKNKDLLNETVVAVFQKSSNRLLASLFen 635
Cdd:cd14907   480 TDEKLLNKIKKQHKNNSKLIFPNKINKDTFT----IRHTAKEVEYNIEGFREKNKDEISQSIINCIQNSKNRIISSIF-- 553
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  636 YMSTDSAIPFGEKKRKKGASFQTVASLHKENLNKLMTNLKSTAPHFVRCINPNVNKIPGILDPYLVLQQLRCNGVLEGTR 715
Cdd:cd14907   554 SGEDGSQQQNQSKQKKSQKKDKFLGSKFRNQMKQLMNELMQCDVHFIRCIKPNEEKKADLFIQGYVLNQIRYLGVLESIR 633
                         650       660       670
                  ....*....|....*....|....*....|..
gi 767926067  716 ICREGFPNRLQYADFKQRYCILNP-RTFPKSK 746
Cdd:cd14907   634 VRKQGYPYRKSYEDFYKQYSLLKKnVLFGKTK 665
PTZ00014 PTZ00014
myosin-A; Provisional
79-838 1.11e-128

myosin-A; Provisional


Pssm-ID: 240229 [Multi-domain]  Cd Length: 821  Bit Score: 425.21  E-value: 1.11e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   79 VETADGESLSIKEDKIQQMNPP-EFEMIEDMAMLTHLNEASVLHTLKRRYGQWMIYTYSGLFCVTINPYKWLPVYQKEVM 157
Cdd:PTZ00014   71 IDPPTNSTFEVKPEHAFNANSQiDPMTYGDIGLLPHTNIPCVLDFLKHRYLKNQIYTTADPLLVAINPFKDLGNTTNDWI 150
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  158 AAYKGKRRSEA-PPHIFAVANNAFQDMLHNRENQSILFTGESGAGKTVNSKHIIQYFATIAAMIESRKKQGAledqIMQA 236
Cdd:PTZ00014  151 RRYRDAKDSDKlPPHVFTTARRALENLHGVKKSQTIIVSGESGAGKTEATKQIMRYFASSKSGNMDLKIQNA----IMAA 226
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  237 NTILEAFGNAKTLRNDNSSRFGKFIRMHFGARGMLSSVDIDIYLLEKSRVIFQQAGERNYHIFYQILSG-----QKELHD 311
Cdd:PTZ00014  227 NPVLEAFGNAKTIRNNNSSRFGRFMQLQLGEEGGIRYGSIVAFLLEKSRVVTQEDDERSYHIFYQLLKGandemKEKYKL 306
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  312 LLLvsanpSDFHFCSCGAVTVESLDDAEELLATEQAMDILGFLPDEKYGCYKLTGAIMHFGNMKFKQKPREEQLEADGTE 391
Cdd:PTZ00014  307 KSL-----EEYKYINPKCLDVPGIDDVKDFEEVMESFDSMGLSESQIEDIFSILSGVLLLGNVEIEGKEEGGLTDAAAIS 381
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  392 NADKAAF-----LMGINSSELVKCLIHPRIKVGNEYVTRGQTIEQVTCAVGALSKSMYERMFKWLVARINRALDAKLSRQ 466
Cdd:PTZ00014  382 DESLEVFneaceLLFLDYESLKKELTVKVTYAGNQKIEGPWSKDESEMLKDSLSKAVYEKLFLWIIRNLNATIEPPGGFK 461
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  467 FFIGILDITGFEILEYNSLEQLCINFTNEKLQQFFNWHMFVLEQEEYKKESIEWVSIGFGLDLQACIDLIEKPMGILSIL 546
Cdd:PTZ00014  462 VFIGMLDIFGFEVFKNNSLEQLFINITNEMLQKNFVDIVFERESKLYKDEGISTEELEYTSNESVIDLLCGKGKSVLSIL 541
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  547 EEECMFPKATDLTFkTKLFDNHFGKSVHLQKPKPDKKKfeaHFELVHYAGVVPYNISGWLEKNKDLLNETVVAVFQKSSN 626
Cdd:PTZ00014  542 EDQCLAPGGTDEKF-VSSCNTNLKNNPKYKPAKVDSNK---NFVIKHTIGDIQYCASGFLFKNKDVLRPELVEVVKASPN 617
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  627 RLLASLFENYMSTDSAIpfgekkrKKGasfQTVASLHKENLNKLMTNLKSTAPHFVRCINPNVNKIPGILDPYLVLQQLR 706
Cdd:PTZ00014  618 PLVRDLFEGVEVEKGKL-------AKG---QLIGSQFLNQLDSLMSLINSTEPHFIRCIKPNENKKPLDWNSSKVLIQLH 687
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  707 CNGVLEGTRICREGFPNRLQYADFKQRYCILNPRTFPKSKfVSSRKAAEELLGSLEIDHTQYRFGITKVFFKAGFLGQLE 786
Cdd:PTZ00014  688 SLSILEALQLRQLGFSYRRTFAEFLSQFKYLDLAVSNDSS-LDPKEKAEKLLERSGLPKDSYAIGKTMVFLKKDAAKELT 766
                         730       740       750       760       770
                  ....*....|....*....|....*....|....*....|....*....|...
gi 767926067  787 AIRDERLSKVFTLFQArAQGKLMRIKFQKILEER-DALILIQWNIRAFMAVKN 838
Cdd:PTZ00014  767 QIQREKLAAWEPLVSV-LEALILKIKKKRKVRKNiKSLVRIQAHLRRHLVIAE 818
MYSc_Myo30 cd14891
class XXX myosin, motor domain; Myosins of class XXX are composed of an amino-terminal ...
117-778 1.24e-126

class XXX myosin, motor domain; Myosins of class XXX are composed of an amino-terminal SH3-like domain, two IQ motifs, a coiled-coil region and a PX domain. The myosin classes XXX to XXXIV contain members from Phytophthora species and Hyaloperonospora parasitica. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276856  Cd Length: 645  Bit Score: 413.29  E-value: 1.24e-126
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  117 ASVLHTLKRRY---GQwMIYTYSGLFCVTINPYKWLPVYQKEvmaAYKGKRRSEAPPHIFAVANNAFQDMLHNRE---NQ 190
Cdd:cd14891     1 AGILHNLEERSkldNQ-RPYTFMANVLIAVNPLRRLPEPDKS---DYINTPLDPCPPHPYAIAEMAYQQMCLGSGrmqNQ 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  191 SILFTGESGAGKTVNSKHIIQY------------FATIAAMIESRKKQGA-LEDQIMQANTILEAFGNAKTLRNDNSSRF 257
Cdd:cd14891    77 SIVISGESGAGKTETSKIILRFlttravggkkasGQDIEQSSKKRKLSVTsLDERLMDTNPILESFGNAKTLRNHNSSRF 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  258 GKFIRMHFGARGM-LSSVDIDIYLLEKSRVIFQQAGERNYHIFYQILSGQKELHDLLLVSANPSDFHFCS-CGAVTVESL 335
Cdd:cd14891   157 GKFMKLQFTKDKFkLAGAFIETYLLEKSRLVAQPPGERNFHIFYQLLAGASAELLKELLLLSPEDFIYLNqSGCVSDDNI 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  336 DDAEELLATEQAMDILGFLPDEKYGCYKLTGAIMHFGNMKFKQKPREEQLEADGTENADKA----AFLMGINSSELVKCL 411
Cdd:cd14891   237 DDAANFDNVVSALDTVGIDEDLQLQIWRILAGLLHLGNIEFDEEDTSEGEAEIASESDKEAlataAELLGVDEEALEKVI 316
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  412 IHPRIKVGNEYVTRGQTIEQVTCAVGALSKSMYERMFKWLVARINRALDAKLSRQFFIGILDITGFEILE-YNSLEQLCI 490
Cdd:cd14891   317 TQREIVTRGETFTIKRNAREAVYSRDAIAKSIYERLFLWIVQQINTSLGHDPDPLPYIGVLDIFGFESFEtKNDFEQLLI 396
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  491 NFTNEKLQQFFNWHMFVLEQEEYKKESIEWVSIGFGlDLQACIDLI-EKPMGILSILEEECMFPKATDLTFKTKLfDNHF 569
Cdd:cd14891   397 NYANEALQATFNQQVFIAEQELYKSEGIDVGVITWP-DNRECLDLIaSKPNGILPLLDNEARNPNPSDAKLNETL-HKTH 474
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  570 GKSVHLQKPKPDKKKFEahFELVHYAGVVPYNISGWLEKNKDLLNETVVAVFqKSSNRLLASLFEnymstdsaipfgekk 649
Cdd:cd14891   475 KRHPCFPRPHPKDMREM--FIVKHYAGTVSYTIGSFIDKNNDIIPEDFEDLL-ASSAKFSDQMQE--------------- 536
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  650 rkkgasfqtvaslhkenlnkLMTNLKSTAPHFVRCINPNVNKIPGILDPYLVLQQLRCNGVLEGTRICREGFPNRLQYAD 729
Cdd:cd14891   537 --------------------LVDTLEATRCNFIRCIKPNAAMKVGVFDNRYVVDQLRCSGILQTCEVLKVGLPTRVTYAE 596
                         650       660       670       680       690
                  ....*....|....*....|....*....|....*....|....*....|
gi 767926067  730 FKQRYCILNPrTFPKSKFVSSRKA-AEELLGSLEIDHTQYRFGITKVFFK 778
Cdd:cd14891   597 LVDVYKPVLP-PSVTRLFAENDRTlTQAILWAFRVPSDAYRLGRTRVFFR 645
MYSc_Myo47 cd14908
class XLVII myosin, motor domain; The class XLVII myosins are comprised of Stramenopiles. Not ...
117-746 2.39e-125

class XLVII myosin, motor domain; The class XLVII myosins are comprised of Stramenopiles. Not much is known about this myosin class. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276873 [Multi-domain]  Cd Length: 682  Bit Score: 411.22  E-value: 2.39e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  117 ASVLHTLKRRYGQWMIYTYSGLFCVTINPYKWLPVYQKEVMAAYK--GKRRS---EAP----PHIFAVANNAFQDMLHN- 186
Cdd:cd14908     1 PAILHSLSRRFFRGIIYTWTGPVLIAVNPFQRLPLYGKEILESYRqeGLLRSqgiESPqalgPHVFAIADRSYRQMMSEi 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  187 RENQSILFTGESGAGKTVNSKHIIQYFATI------AAMIESRKKQGALEDQIMQANTILEAFGNAKTLRNDNSSRFGKF 260
Cdd:cd14908    81 RASQSILISGESGAGKTESTKIVMLYLTTLgngeegAPNEGEELGKLSIMDRVLQSNPILEAFGNARTLRNDNSSRFGKF 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  261 IRMHFGARGMLSSVDIDIYLLEKSRVIFQQAGERNYHIFYQILSG-------QKELHDLLLVSAN-PSDFHFCSCG-AVT 331
Cdd:cd14908   161 IELGFNRAGNLLGAKVQTYLLEKVRLPFHASGERNYHIFYQLLRGgdeeeheKYEFHDGITGGLQlPNEFHYTGQGgAPD 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  332 VESLDDAEELLATEQAMDILGFLPDEKYGCYKLTGAIMHFGNMKFKQKPREEQLEADGTENAD---KAAFLMGINSSELV 408
Cdd:cd14908   241 LREFTDEDGLVYTLKAMRTMGWEESSIDTILDIIAGLLHLGQLEFESKEEDGAAEIAEEGNEKclaRVAKLLGVDVDKLL 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  409 KCLIHPRIKVGNEYVTRGQTIEQVTCAVGALSKSMYERMFKWLVARINRALDAKLSRQF--FIGILDITGFEILEYNSLE 486
Cdd:cd14908   321 RALTSKIIVVRGKEITTKLTPHKAYDARDALAKTIYGALFLWVVATVNSSINWENDKDIrsSVGVLDIFGFECFAHNSFE 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  487 QLCINFTNEKLQQFFNWHMFVLEQEEYKKESIEWVSIGFGlDLQACIDLIE-KPMGILSILEEECMFP-KATDLTFKTKL 564
Cdd:cd14908   401 QLCINFTNEALQQQFNQFIFKLEQKEYEKESIEWAFIEFP-DNQDCLDTIQaKKKGILTMLDDECRLGiRGSDANYASRL 479
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  565 FDNHFGKSvhlQKPKPDKKKFEAH--------FELVHYAGVVPYNI-SGWLEKNKDLLNETVvavfqkssnrllASLFEN 635
Cdd:cd14908   480 YETYLPEK---NQTHSENTRFEATsiqktkliFAVRHFAGQVQYTVeTTFCEKNKDEIPLTA------------DSLFES 544
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  636 ymstdsaipfgekkrkkGASFqtvaslhKENLNKLMTNLKSTAPHFVRCINPNVNKIPGILDPYLVLQQLRCNGVLEGTR 715
Cdd:cd14908   545 -----------------GQQF-------KAQLHSLIEMIEDTDPHYIRCIKPNDAAKPDLVTRKRVTEQLRYGGVLEAVR 600
                         650       660       670
                  ....*....|....*....|....*....|.
gi 767926067  716 ICREGFPNRLQYADFKQRYCILNPrTFPKSK 746
Cdd:cd14908   601 VARSGYPVRLPHKDFFKRYRMLLP-LIPEVV 630
MYSc_Myo35 cd14896
class XXXV myosin, motor domain; This class of metazoan myosins contains 2 IQ motifs, 2 MyTH4 ...
117-778 6.33e-124

class XXXV myosin, motor domain; This class of metazoan myosins contains 2 IQ motifs, 2 MyTH4 domains, a single FERM domain, and an SH3 domain. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276861 [Multi-domain]  Cd Length: 644  Bit Score: 405.70  E-value: 6.33e-124
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  117 ASVLHTLKRRYGQWMIYTYSGLFCVTINPYKWLPVYQKEVMAAYKGKRRSEAPPHIFAVANNAFQDMLHNRENQSILFTG 196
Cdd:cd14896     1 SSVLLCLKKRFHLGRIYTFGGPILLSLNPHRSLPLFSEEVLASYHPRKALNTTPHIFAIAASAYRLSQSTGQDQCILLSG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  197 ESGAGKTVNSKHIIQYFATIaamieSRKKQGALEDQIMQANTILEAFGNAKTLRNDNSSRFGKFIRMHFgARGMLSSVDI 276
Cdd:cd14896    81 HSGSGKTEAAKKIVQFLSSL-----YQDQTEDRLRQPEDVLPILESFGHAKTILNANASRFGQVLRLHL-QHGVIVGASV 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  277 DIYLLEKSRVIFQQAGERNYHIFYQILSG----QKElhdLLLVSANPSDFHFCSCGAVTVESLDDAEELLATEQAMDILG 352
Cdd:cd14896   155 SHYLLETSRVVFQAQAERSFHVFYELLAGldpeERE---QLSLQGPETYYYLNQGGACRLQGKEDAQDFEGLLKALQGLG 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  353 FLPDEKYGCYKLTGAIMHFGNMKFKQKPREEQLEADGTENAD--KAAFLMGINSSELVKCLIHPRIKVGNEYVTRGQTIE 430
Cdd:cd14896   232 LCAEELTAIWAVLAAILQLGNICFSSSERESQEVAAVSSWAEihTAARLLQVPPERLEGAVTHRVTETPYGRVSRPLPVE 311
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  431 QVTCAVGALSKSMYERMFKWLVARINRALDAKLSRQFF--IGILDITGFEILEYNSLEQLCINFTNEKLQQFFNWHMFVL 508
Cdd:cd14896   312 GAIDARDALAKTLYSRLFTWLLKRINAWLAPPGEAESDatIGVVDAYGFEALRVNGLEQLCINLASERLQLFSSQTLLAQ 391
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  509 EQEEYKKESIEWVSIgFGLDLQACIDLI-EKPMGILSILEEECMFPKATDLTFKTKLFDNHfGKSVHLQKPKPDKKKFEA 587
Cdd:cd14896   392 EEEECQRELLPWVPI-PQPPRESCLDLLvDQPHSLLSILDDQTWLSQATDHTFLQKCHYHH-GDHPSYAKPQLPLPVFTV 469
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  588 HfelvHYAGVVPYNISGWLEKNKDLLNETVVAVFQKSSNRLLASLFENymstdsaipfGEKKRKKGASFQTVASLHKENL 667
Cdd:cd14896   470 R----HYAGTVTYQVHKFLNRNRDQLDPAVVEMLAQSQLQLVGSLFQE----------AEPQYGLGQGKPTLASRFQQSL 535
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  668 NKLMTNLKSTAPHFVRCINPNVNKIPGILDPYLVLQQLRCNGVLEGTRICREGFPNRLQYADFKQRYCILNPRtfpKSKF 747
Cdd:cd14896   536 GDLTARLGRSHVYFIHCLNPNPGKLPGLFDVGHVTEQLRQAGILEAIGTRSEGFPVRVPFQAFLARFGALGSE---RQEA 612
                         650       660       670
                  ....*....|....*....|....*....|..
gi 767926067  748 VSSRKAAEELLGSLEIDHTQ-YRFGITKVFFK 778
Cdd:cd14896   613 LSDRERCGAILSQVLGAESPlYHLGATKVLLK 644
MYSc_Myo34 cd14895
class XXXIV myosin, motor domain; Class XXXIV myosins are composed of an IQ motif, a short ...
118-778 7.48e-122

class XXXIV myosin, motor domain; Class XXXIV myosins are composed of an IQ motif, a short coiled-coil region, 5 tandem ANK repeats, and a carboxy-terminal FYVE domain. The myosin classes XXX to XXXIV contain members from Phytophthora species and Hyaloperonospora parasitica. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276860 [Multi-domain]  Cd Length: 704  Bit Score: 402.02  E-value: 7.48e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  118 SVLHTLKRRYGQWMIYTYSGLFCVTINPYKWLP-VYQ----KEVMAAYKGKrrseaPPHIFAVANNAFQDM---LH---- 185
Cdd:cd14895     2 AFVDYLAQRYGVDQVYCRSGAVLIAVNPFKHIPgLYDlhkyREEMPGWTAL-----PPHVFSIAEGAYRSLrrrLHepga 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  186 NRENQSILFTGESGAGKTVNSKHIIQYFATIA----AMIESRKKQGALEDQIMQANTILEAFGNAKTLRNDNSSRFGKFI 261
Cdd:cd14895    77 SKKNQTILVSGESGAGKTETTKFIMNYLAESSkhttATSSSKRRRAISGSELLSANPILESFGNARTLRNDNSSRFGKFV 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  262 RMHFGARGMLSSV-----DIDIYLLEKSRVIFQQAGERNYHIFYQILSGQKE--LHDLLLVSANPSDFHFCSCGAVTV-- 332
Cdd:cd14895   157 RMFFEGHELDTSLrmigtSVETYLLEKVRVVHQNDGERNFHVFYELLAGAADdmKLELQLELLSAQEFQYISGGQCYQrn 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  333 ESLDDAEELLATEQAMDILGFLPDEKYGCYKLTGAIMHFGNMKFKQKPREEQLEADGTENA------------------D 394
Cdd:cd14895   237 DGVRDDKQFQLVLQSMKVLGFTDVEQAAIWKILSALLHLGNVLFVASSEDEGEEDNGAASApcrlasaspssltvqqhlD 316
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  395 KAAFLMGINSSELVKCLIHPRIKVGNEYVTRGQTIEQVTCAVGALSKSMYERMFKWLVARINRALDaklSRQF------- 467
Cdd:cd14895   317 IVSKLFAVDQDELVSALTTRKISVGGETFHANLSLAQCGDARDAMARSLYAFLFQFLVSKVNSASP---QRQFalnpnka 393
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  468 -------FIGILDITGFEILEYNSLEQLCINFTNEKLQQFFNWHMFVLEQEEYKKESIEWVSIGFGLDlQACIDLIE-KP 539
Cdd:cd14895   394 ankdttpCIAVLDIFGFEEFEVNQFEQFCINYANEKLQYQFIQDILLTEQQAHIEEGIKWNAVDYEDN-SVCLEMLEqRP 472
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  540 MGILSILEEECMFPKATDLTFKTKLFDNHFGKSvHLQKPKPDKKKFEahFELVHYAGVVPYNISGWLEKNKDLLNETVVA 619
Cdd:cd14895   473 SGIFSLLDEECVVPKGSDAGFARKLYQRLQEHS-NFSASRTDQADVA--FQIHHYAGAVRYQAEGFCEKNKDQPNAELFS 549
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  620 VFQKSSNRLLASLFENY-MSTDSAIPFGE---KKRKKGASFQTVASLHKENLNKLMTNLKSTAPHFVRCINPNVNKIPGI 695
Cdd:cd14895   550 VLGKTSDAHLRELFEFFkASESAELSLGQpklRRRSSVLSSVGIGSQFKQQLASLLDVVQQTQTHYIRCIKPNDESASDQ 629
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  696 LDPYLVLQQLRCNGVLEGTRICREGFPNRLQYADFKQRYcilnpRTFPKSKFVSSRKAAeELLGSLEIDHTQyrFGITKV 775
Cdd:cd14895   630 FDMAKVSSQLRYGGVLKAVEIMRQSYPVRMKHADFVKQY-----RLLVAAKNASDATAS-ALIETLKVDHAE--LGKTRV 701

                  ...
gi 767926067  776 FFK 778
Cdd:cd14895   702 FLR 704
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
859-1935 4.60e-116

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 396.47  E-value: 4.60e-116
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   859 EEVAGLKEEcaQLQKALE---KSEFQREELKAKQVSLTQEKNDLILQLQAEQETLANVEEQCEWLIKSKIQLEARVKELS 935
Cdd:pfam01576    4 EEEMQAKEE--ELQKVKErqqKAESELKELEKKHQQLCEEKNALQEQLQAETELCAEAEEMRARLAARKQELEEILHELE 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   936 ERVEEEEEINSELTARGRKLEDECFELKKEIDDLETMLVKSEKEKRTTEHKVKNLTEEVEFLNEDISKLNRAAKVVQEAH 1015
Cdd:pfam01576   82 SRLEEEEERSQQLQNEKKKMQQHIQDLEEQLDEEEAARQKLQLEKVTTEAKIKKLEEDILLLEDQNSKLSKERKLLEERI 161
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1016 QQTLDDLHMEEEKLSSLSKANLKLEQQVDELEGALEQERKARMNCERELHKLEGNLKLNRESMENLESSQRHLAEELRKK 1095
Cdd:pfam01576  162 SEFTSNLAEEEEKAKSLSKLKNKHEAMISDLEERLKKEEKGRQELEKAKRKLEGESTDLQEQIAELQAQIAELRAQLAKK 241
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1096 ELELSQMNSKVENEKGLVAQLQKTVKELQTQIKDLKEKLEAERTTRAKMERERADLTQDLADLNERLEEVGGSSLAQLEI 1175
Cdd:pfam01576  242 EEELQAALARLEEETAQKNNALKKIRELEAQISELQEDLESERAARNKAEKQRRDLGEELEALKTELEDTLDTTAAQQEL 321
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1176 TKKQETKFQKLHRDMEEATLHFETTSASLKKRHADSLAELEGQVENLQQVKQKLEKDKSDLQLEVDDLLTRVEQMTRAKA 1255
Cdd:pfam01576  322 RSKREQEVTELKKALEEETRSHEAQLQEMRQKHTQALEELTEQLEQAKRNKANLEKAKQALESENAELQAELRTLQQAKQ 401
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1256 NAEKLCTLYEERLHEATAKLDKVTQLANDLAAQKTKLWSESGEFLRRLEEKEALINQLSREKSNFTRQIEDLRGQLEKET 1335
Cdd:pfam01576  402 DSEHKRKKLEGQLQELQARLSESERQRAELAEKLSKLQSELESVSSLLNEAEGKNIKLSKDVSSLESQLQDTQELLQEET 481
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1336 KSQSALAHALQKAQRDCDLLREQYEEEQEVKAELHRTLSKVNAEMVQWRMKYEnNVIQRTEDLEDAKKELAIRLQEAAEA 1415
Cdd:pfam01576  482 RQKLNLSTRLRQLEDERNSLQEQLEEEEEAKRNVERQLSTLQAQLSDMKKKLE-EDAGTLEALEEGKKRLQRELEALTQQ 560
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1416 MGVANARNASLERARHQLQLELGDALSDLGKVRSAAARLDQKQLQSGKALADWKQ-----KHEESQALLDASQKEVQALS 1490
Cdd:pfam01576  561 LEEKAAAYDKLEKTKNRLQQELDDLLVDLDHQRQLVSNLEKKQKKFDQMLAEEKAisaryAEERDRAEAEAREKETRALS 640
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1491 tellkLKNTYEESIVGQETLRRENKNLQEEISNLTNQVREGTKNLTEMEKVKKLIEEEKTEVQVTLEETEGALERNESKI 1570
Cdd:pfam01576  641 -----LARALEEALEAKEELERTNKQLRAEMEDLVSSKDDVGKNVHELERSKRALEQQVEEMKTQLEELEDELQATEDAK 715
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1571 LHFQLELLEAKAELERKLSEKDEEIENFRRKQQCTIDSLQSSLDSEAKSRIEVTRLKKKMEEDLNEMELQLSCANRQVSE 1650
Cdd:pfam01576  716 LRLEVNMQALKAQFERDLQARDEQGEEKRRQLVKQVRELEAELEDERKQRAQAVAAKKKLELDLKELEAQIDAANKGREE 795
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1651 ATKSLGQLQIQIKDLQMQLDDSTQLNSDLKEQVAVAERRNSLLQSELEDLRSLQEQTERGRRLSEEELLEATERINLFYT 1730
Cdd:pfam01576  796 AVKQLKKLQAQMKDLQRELEEARASRDEILAQSKESEKKLKNLEAELLQLQEDLAASERARRQAQQERDELADEIASGAS 875
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1731 QNTSLLSQKKKLEADVARMQKEAEEVVQECQNAEEKAKKAAIEAANLSEELKKKQDTIAHLERTRENMEQTITDLQKRLA 1810
Cdd:pfam01576  876 GKSALQDEKRRLEARIAQLEEELEEEQSNTELLNDRLRKSTLQVEQLTTELAAERSTSQKSESARQQLERQNKELKAKLQ 955
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1811 EAEQMALMGSRKQIQKLESRVRELEGELEGEIRRSAEAQRGARRLERCIKELTYQAEEDKKNLSRMQTQMDKLQLKVQNY 1890
Cdd:pfam01576  956 EMEGTVKSKFKSSIAALEAKIAQLEEQLEQESRERQAANKLVRRTEKKLKEVLLQVEDERRHADQYKDQAEKGNSRMKQL 1035
                         1050      1060      1070      1080
                   ....*....|....*....|....*....|....*....|....*
gi 767926067  1891 KQQVEVAETQANQYLSKYKKQQHELNEVKERAEVAESQVNKLKIK 1935
Cdd:pfam01576 1036 KRQLEEAEEEASRANAARRKLQRELDDATESNESMNREVSTLKSK 1080
MYSc_Myo14 cd14876
class XIV myosin, motor domain; These myosins localize to plasma membranes of the ...
117-778 1.00e-114

class XIV myosin, motor domain; These myosins localize to plasma membranes of the intracellular parasites and may be involved in the cell invasion process. Their known functions include: transporting phagosomes to the nucleus and perturbing the developmentally regulated elimination of the macronucleus during conjugation. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. C-terminal to their motor domain these myosins have a MyTH4-FERM protein domain combination. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276843  Cd Length: 649  Bit Score: 379.72  E-value: 1.00e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  117 ASVLHTLKRRYGQWMIYTYSGLFCVTINPYKWLPVYQKEVMAAYKG-KRRSEAPPHIFAVANNAFQDMLHNRENQSILFT 195
Cdd:cd14876     1 PCVLDFLKHRYLKNQIYTTADPLLVAINPFKDLGNATDEWIRKYRDaPDLTKLPPHVFYTARRALENLHGVNKSQTIIVS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  196 GESGAGKTVNSKHIIQYFATIAAMIESRKKQGAledqIMQANTILEAFGNAKTLRNDNSSRFGKFIRMHFGARGMLSSVD 275
Cdd:cd14876    81 GESGAGKTEATKQIMRYFASAKSGNMDLRIQTA----IMAANPVLEAFGNAKTIRNNNSSRFGRFMQLDVASEGGIRYGS 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  276 IDIYLLEKSRVIFQQAGERNYHIFYQILSG----QKELHDLLLVSanpsDFHFCSCGAVTVESLDDAEELLATEQAMDIL 351
Cdd:cd14876   157 VVAFLLEKSRIVTQDDNERSYHIFYQLLKGadseMKSKYHLLGLK----EYKFLNPKCLDVPGIDDVADFEEVLESLKSM 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  352 GFLPDEKYGCYKLTGAIMHFGNMKFKQKPREEQLEADGTENADKAAF-----LMGINSSELVKCLIHPRIKVGNEYVTRG 426
Cdd:cd14876   233 GLTEEQIDTVFSIVSGVLLLGNVKITGKTEQGVDDAAAISNESLEVFkeacsLLFLDPEALKRELTVKVTKAGGQEIEGR 312
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  427 QTIEQVTCAVGALSKSMYERMFKWLVARINRALDAKLSRQFFIGILDITGFEILEYNSLEQLCINFTNEKLQQFFNWHMF 506
Cdd:cd14876   313 WTKDDAEMLKLSLAKAMYDKLFLWIIRNLNSTIEPPGGFKNFMGMLDIFGFEVFKNNSLEQLFINITNEMLQKNFIDIVF 392
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  507 VLEQEEYKKESIEWVSIGFGLDLQACIDLIEKPMGILSILEEECMFPKATDLTF----KTKLFDNhfgksvhlQKPKPDK 582
Cdd:cd14876   393 ERESKLYKDEGIPTAELEYTSNAEVIDVLCGKGKSVLSILEDQCLAPGGSDEKFvsacVSKLKSN--------GKFKPAK 464
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  583 KKFEAHFELVHYAGVVPYNISGWLEKNKDLLNETVVAVFQKSSNRLLASLFENymstdsaIPFGEKKRKKGasfQTVASL 662
Cdd:cd14876   465 VDSNINFIVVHTIGDIQYNAEGFLFKNKDVLRAELVEVVQASTNPVVKALFEG-------VVVEKGKIAKG---SLIGSQ 534
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  663 HKENLNKLMTNLKSTAPHFVRCINPNVNKIPGILDPYLVLQQLRCNGVLEGTRICREGFPNRLQYADFKQRYCILNPrTF 742
Cdd:cd14876   535 FLKQLESLMGLINSTEPHFIRCIKPNETKKPLEWNSSKVLIQLHALSILEALQLRQLGYSYRRPFEEFLYQFKFLDL-GI 613
                         650       660       670
                  ....*....|....*....|....*....|....*.
gi 767926067  743 PKSKFVSSRKAAEELLGSLEIDHTQYRFGITKVFFK 778
Cdd:cd14876   614 ANDKSLDPKVAALKLLESSGLSEDEYAIGKTMVFLK 649
MYSc_Myo19 cd14880
class XIX myosin, motor domain; Monomeric myosin-XIX (Myo19) functions as an actin-based motor ...
117-776 2.29e-111

class XIX myosin, motor domain; Monomeric myosin-XIX (Myo19) functions as an actin-based motor for mitochondrial movement in vertebrate cells. It contains a variable number of IQ domains. Human myo19 contains a motor domain, three IQ motifs, and a short tail. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276846 [Multi-domain]  Cd Length: 658  Bit Score: 370.33  E-value: 2.29e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  117 ASVLHTLKRRYGQWMIYTYSGLFCVTINPYKWLP-VYQKEVMAAYKGKRRSEA-PPHIFAVANNAFQDMLHNRE--NQSI 192
Cdd:cd14880     1 ETVLRCLQARYTADTFYTNAGCTLVALNPFKPVPqLYSPELMREYHAAPQPQKlKPHIFTVGEQTYRNVKSLIEpvNQSI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  193 LFTGESGAGKTVNSKHIIQYFATIAA---MIESRKKQGALEDQIMQANTILEAFGNAKTLRNDNSSRFGKFIRMHFGARG 269
Cdd:cd14880    81 VVSGESGAGKTWTSRCLMKFYAVVAAsptSWESHKIAERIEQRILNSNPVMEAFGNACTLRNNNSSRFGKFIQLQLNRAQ 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  270 MLSSVDIDIYLLEKSRVIFQQAGERNYHIFYQILSGQKELHDLLLVSANPSDFHFCSCGAVTVESlDDAEellATEQAMD 349
Cdd:cd14880   161 QMTGAAVQTYLLEKTRVACQAPSERNFHIFYQICKGASADERLQWHLPEGAAFSWLPNPERNLEE-DCFE---VTREAML 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  350 ILGFLPDEKYGCYKLTGAIMHFGNMKFKQKPREEQ---LEADGTENADKAAFLMGINSSELVKCLIHPRIKVGNEYVTRG 426
Cdd:cd14880   237 HLGIDTPTQNNIFKVLAGLLHLGNIQFADSEDEAQpcqPMDDTKESVRTSALLLKLPEDHLLETLQIRTIRAGKQQQVFK 316
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  427 QTIEQVTCAV--GALSKSMYERMFKWLVARINRALDAKLSR-QFFIGILDITGFEILEYNSLEQLCINFTNEKLQQFFNW 503
Cdd:cd14880   317 KPCSRAECDTrrDCLAKLIYARLFDWLVSVINSSICADTDSwTTFIGLLDVYGFESFPENSLEQLCINYANEKLQQHFVA 396
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  504 HMFVLEQEEYKKESIEWVSIGFGlDLQACIDLIE-KPMGILSILEEECMFPKATDLT-FKTKLfdnhfgKSVHLQKPKPD 581
Cdd:cd14880   397 HYLRAQQEEYAVEGLEWSFINYQ-DNQTCLDLIEgSPISICSLINEECRLNRPSSAAqLQTRI------ESALAGNPCLG 469
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  582 KKKF--EAHFELVHYAGVVPYNISGWLEKNKDLLNETVVAVFQKSSNRLLASLF--------ENYMSTDSAIPfgekkrk 651
Cdd:cd14880   470 HNKLsrEPSFIVVHYAGPVRYHTAGLVEKNKDPVPPELTRLLQQSQDPLLQKLFpanpeektQEEPSGQSRAP------- 542
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  652 kgasFQTVASLHKENLNKLMTNLKSTAPHFVRCINPNVNKIPGILDPYLVLQQLRCNGVLEGTRICREGFPNRLQYADFK 731
Cdd:cd14880   543 ----VLTVVSKFKASLEQLLQVLHSTTPHYIRCIKPNSQCQAQTFLQEEVLSQLEACGLVETIHISAAGFPIRVSHQNFV 618
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|....*
gi 767926067  732 QRYCILNPRTFPKSKFVSSRKAAEELLGSLEIdhtqyrfGITKVF 776
Cdd:cd14880   619 ERYKLLRRLRPHTSSGPHSPYPAKGLSEPVHC-------GRTKVF 656
MYSc_Myo38 cd14899
class XXXVIII myosin; The class XXXVIII myosins are comprised of Stramenopiles. Not much is ...
117-734 1.23e-109

class XXXVIII myosin; The class XXXVIII myosins are comprised of Stramenopiles. Not much is known about this myosin class. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276864 [Multi-domain]  Cd Length: 717  Bit Score: 367.50  E-value: 1.23e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  117 ASVLHTLKRRYGQWMIYTYSGLFCVTINPYKWLP-VYQKEVMAAYK-------GKRRSEA---PPHIFAVANNAFQDMLH 185
Cdd:cd14899     1 ASILNALRLRYERHAIYTHIGDILISINPFQDLPqLYGDEILRGYAydhnsqfGDRVTSTdprEPHLFAVARAAYIDIVQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  186 NRENQSILFTGESGAGKTVNSKHIIQYFA------------TIAAMIESRKKQGALEDQIMQANTILEAFGNAKTLRNDN 253
Cdd:cd14899    81 NGRSQSILISGESGAGKTEATKIIMTYFAvhcgtgnnnltnSESISPPASPSRTTIEEQVLQSNPILEAFGNARTVRNDN 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  254 SSRFGKFIRMHF-GARGMLSSVDIDIYLLEKSRVIFQQAGERNYHIFYQILSG-----QKELHDLLLVSANPSDFHFC-- 325
Cdd:cd14899   161 SSRFGKFIELRFrDERRRLAGARIRTYLLEKIRVIKQAPHERNFHIFYELLSAdnncvSKEQKQVLALSGGPQSFRLLnq 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  326 SCGAVTVESLDDAEELLATEQAMDILGFLPDEKYGCYKLTGAIMHFGNMKFKQKP--REEQLEADGTENA---------- 393
Cdd:cd14899   241 SLCSKRRDGVKDGVQFRATKRAMQQLGMSEGEIGGVLEIVAAVLHMGNVDFEQIPhkGDDTVFADEARVMssttgafdhf 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  394 DKAAFLMGINSSELVKCLIHPRIKVGNEYVTRGQTIEQVTCAVGALSKSMYERMFKWLVARINRALDAKLSRQF------ 467
Cdd:cd14899   321 TKAAELLGVSTEALDHALTKRWLHASNETLVVGVDVAHARNTRNALTMECYRLLFEWLVARVNNKLQRQASAPWgadesd 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  468 ---------FIGILDITGFEILEYNSLEQLCINFTNEKLQQFFNWHMFVLEQEEYKKESIEWVSIGFGLDlQACIDLIE- 537
Cdd:cd14899   401 vddeedatdFIGLLDIFGFEDMAENSFEQLCINYANEALQHQFNQYIFEEEQRLYRDEGIRWSFVDFPNN-RACLELFEh 479
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  538 KPMGILSILEEECMFPKATDLTFKTKLFDNHFGKSVHLQKPKPDKKKFEAHFELVHYAGVVPYNISGWLEKNKDLLNETV 617
Cdd:cd14899   480 RPIGIFSLTDQECVFPQGTDRALVAKYYLEFEKKNSHPHFRSAPLIQRTTQFVVAHYAGCVTYTIDGFLAKNKDSFCESA 559
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  618 VAVFQKSSNRLLASL-----FENYMSTDSAIPFGEKKRKKGASFQ---TVASLHKENLNKLMTNLKSTAPHFVRCINPNV 689
Cdd:cd14899   560 AQLLAGSSNPLIQALaagsnDEDANGDSELDGFGGRTRRRAKSAIaavSVGTQFKIQLNELLSTVRATTPRYVRCIKPND 639
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|....*
gi 767926067  690 NKIPGILDPYLVLQQLRCNGVLEGTRICREGFPNRLQYADFKQRY 734
Cdd:cd14899   640 SHVGSLFQSTRVVEQLRSGGVLEAVRVARAGFPVRLTHKQFLGRY 684
MYSc_Myo18 cd01386
class XVIII myosin, motor domain; Many members of this class contain a N-terminal PDZ domain ...
117-778 3.30e-109

class XVIII myosin, motor domain; Many members of this class contain a N-terminal PDZ domain which is commonly found in proteins establishing molecular complexes. The motor domain itself does not exhibit ATPase activity, suggesting that it functions as an actin tether protein. It also has two IQ domains that probably bind light chains or related calmodulins and a C-terminal tail with two sections of coiled-coil domains, which are thought to mediate homodimerization. The function of these myosins are largely unknown. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276837 [Multi-domain]  Cd Length: 689  Bit Score: 365.09  E-value: 3.30e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  117 ASVLHTLKRRYGQWMIYTYSGLFCVTINPYKWLPVYQKEVMAAYKGKRRSEAPPHIFAVANNAFQDMLHNRENQSILFTG 196
Cdd:cd01386     1 SSVLHTLRQRYGANLIHTYAGPSLIVINPRHPLAVYSEKVAKMFKGCRREDMPPHIYASAQSAYRAMLMSRRDQSIVLLG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  197 ESGAGKTVNSKHIIQYFATIAAMIESRKKQgaleDQIMQANTILEAFGNAKTLRNDNSSRFGKFIRMHFGARGMLSSVDI 276
Cdd:cd01386    81 RSGSGKTTNCRHILEYLVTAAGSVGGVLSV----EKLNAALTVLEAFGNVRTALNGNATRFSQLFSLDFDQAGQLASASI 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  277 DIYLLEKSRVIFQQAGERNYHIFYQILSG-----QKELH-DLLLVS--------ANPSDFHfcscgavtveslDDAEELL 342
Cdd:cd01386   157 QTLLLERSRVARRPEGESNFNVFYYLLAGadaalRTELHlNQLAESnsfgivplQKPEDKQ------------KAAAAFS 224
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  343 ATEQAMDILGFLPDEKYGCYKLTGAIMHFGN---MKFKQKPREEQLEadgTENADKAAFLMGINSSELVKCLIHPRIKVG 419
Cdd:cd01386   225 KLQAAMKTLGISEEEQRAIWSILAAIYHLGAagaTKAASAGRKQFAR---PEWAQRAAYLLGCTLEELSSAIFKHHLSGG 301
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  420 NEYVTRGQTIEQVTC------------AVGALSKSMYERMFKWLVARINRALDAKLSRQFFIGILDITGFEILEYN---- 483
Cdd:cd01386   302 PQQSTTSSGQESPARsssggpkltgveALEGFAAGLYSELFAAVVSLINRSLSSSHHSTSSITIVDTPGFQNPAHSgsqr 381
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  484 --SLEQLCINFTNEKLQQFFNWHMFVLEQEEYKKESIEwVSIGFGLD-LQACIDLIEK---------------PMGILSI 545
Cdd:cd01386   382 gaTFEDLCHNYAQERLQLLFHERTFVAPLERYKQENVE-VDFDLPELsPGALVALIDQapqqalvrsdlrdedRRGLLWL 460
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  546 LEEECMFPKATDLTFKTKLFdNHFGKSVHLQKPKPDKKKFEA-HFELVHYAGV--VPYNISGWLEKNK-DLLNETVVAVF 621
Cdd:cd01386   461 LDEEALYPGSSDDTFLERLF-SHYGDKEGGKGHSLLRRSEGPlQFVLGHLLGTnpVEYDVSGWLKAAKeNPSAQNATQLL 539
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  622 QkSSNRLLASLfenymstdsaipfgekkRKKGASFQTvaslhKENLNKLMTNLKSTAPHFVRCINPNVNKIPG------- 694
Cdd:cd01386   540 Q-ESQKETAAV-----------------KRKSPCLQI-----KFQVDALIDTLRRTGLHFVHCLLPQHNAGKDerstssp 596
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  695 -----ILDPYLVLQQLRCNGVLEGTRICREGFPNRLQYADFKQRYCILNP----RTFPKSKFVSSRKAAEELLGSLEIDH 765
Cdd:cd01386   597 aagdeLLDVPLLRSQLRGSQLLDALRLYRQGFPDHMPLGEFRRRFQVLAPpltkKLGLNSEVADERKAVEELLEELDLEK 676
                         730
                  ....*....|...
gi 767926067  766 TQYRFGITKVFFK 778
Cdd:cd01386   677 SSYRIGLSQVFFR 689
MYSc_Myo45 cd14906
class XLV myosin, motor domain; The class XLVI myosins are comprised of slime molds ...
117-738 2.71e-107

class XLV myosin, motor domain; The class XLVI myosins are comprised of slime molds Dictyostelium and Polysphondylium. Not much is known about this myosin class. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276871 [Multi-domain]  Cd Length: 715  Bit Score: 360.45  E-value: 2.71e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  117 ASVLHTLKRRYGQWMIYTYSGLFCVTINPYKWLP-VYQKEVMAAYKGKRR-SEAPPHIFAVANNAFQDMLHNRENQSILF 194
Cdd:cd14906     1 AIILNNLGKRYKSDSIYTYIGNVLISINPYKDISsIYSNLILNEYKDINQnKSPIPHIYAVALRAYQSMVSEKKNQSIII 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  195 TGESGAGKTVNSKHIIQYF-----ATIAAMIESRKKQGALEDQIMQANTILEAFGNAKTLRNDNSSRFGKFIRMHF-GAR 268
Cdd:cd14906    81 SGESGSGKTEASKTILQYLintssSNQQQNNNNNNNNNSIEKDILTSNPILEAFGNSRTTKNHNSSRFGKFLKIEFrSSD 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  269 GMLSSVDIDIYLLEKSRVIFQ-QAGERNYHIFYQILSG-QKELHDLLLVSANPSDFHFCSCGAVTVESL----------- 335
Cdd:cd14906   161 GKIDGASIETYLLEKSRISHRpDNINLSYHIFYYLVYGaSKDERSKWGLNNDPSKYRYLDARDDVISSFksqssnknsnh 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  336 ----DDAEELLATEQAMDILGFLPDEKYGCYKLTGAIMHFGNMKFKQKP---REEQLEADGTENADKAAFLMGINSSELV 408
Cdd:cd14906   241 nnktESIESFQLLKQSMESMSINKEQCDAIFLSLAAILHLGNIEFEEDSdfsKYAYQKDKVTASLESVSKLLGYIESVFK 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  409 KCLIHPRIKVGNE--YVTRGQTIEQVTCAVGALSKSMYERMFKWLVARINRA---------LDAKLSRQ--FFIGILDIT 475
Cdd:cd14906   321 QALLNRNLKAGGRgsVYCRPMEVAQSEQTRDALSKSLYVRLFKYIVEKINRKfnqntqsndLAGGSNKKnnLFIGVLDIF 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  476 GFEILEYNSLEQLCINFTNEKLQQFFNWHMFVLEQEEYKKESIEWVSIGFgLDLQACIDLIE-KPMGILSILEEECMFPK 554
Cdd:cd14906   401 GFENLSSNSLEQLLINFTNEKLQQQFNLNVFENEQKEYLSEGIPWSNSNF-IDNKECIELIEkKSDGILSLLDDECIMPK 479
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  555 ATDLTFKTKlfdnhFGKSVHlQKPKPDKKKF-EAHFELVHYAGVVPYNISGWLEKNKDLLNETVVAVFQKSSNRLLASLF 633
Cdd:cd14906   480 GSEQSLLEK-----YNKQYH-NTNQYYQRTLaKGTLGIKHFAGDVTYQTDGWLEKNRDSLYSDVEDLLLASSNFLKKSLF 553
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  634 enymSTDSAIPFGEKKRKKGASfqTVASLHKENLNKLMTNLKSTAPHFVRCINPNVNKIPGILDPYLVLQQLRCNGVLEG 713
Cdd:cd14906   554 ----QQQITSTTNTTKKQTQSN--TVSGQFLEQLNQLIQTINSTSVHYIRCIKPNQTMDCNNFNNVHVLSQLRNVGVLNT 627
                         650       660
                  ....*....|....*....|....*.
gi 767926067  714 TRICREGFPNRLQYADFKQRY-CILN 738
Cdd:cd14906   628 IKVRKMGYSYRRDFNQFFSRYkCIVD 653
MYSc_Myo13 cd14875
class XIII myosin, motor domain; These myosins have an N-terminal motor domain, a light-chain ...
117-778 5.26e-103

class XIII myosin, motor domain; These myosins have an N-terminal motor domain, a light-chain binding domain, and a C-terminal GPA/Q-rich domain. There is little known about the function of this myosin class. Two of the earliest members identified in this class are green alga Acetabularia cliftonii, Aclmyo1 and Aclmyo2. They are striking with their short tail of Aclmyo1 of 18 residues and the maximum of 7 IQ motifs in Aclmyo2. It is thought that these myosins are involved in organelle transport and tip growth. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276842 [Multi-domain]  Cd Length: 664  Bit Score: 346.41  E-value: 5.26e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  117 ASVLHTLKRRYGQWMI-YTYSGLFCVTINPYKWLPVYQKEVMAAYKGKRRSEA-PPHIFAVANNAF-QDMLHNRENQSIL 193
Cdd:cd14875     1 ATLLHCIKERFEKLHQqYSLMGEMVLSVNPFRLMPFNSEEERKKYLALPDPRLlPPHIWQVAHKAFnAIFVQGLGNQSVV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  194 FTGESGAGKTVNSKHIIQYFATIAAMIESRKKQGALEDQIMQ----ANTILEAFGNAKTLRNDNSSRFGKFIRMHF-GAR 268
Cdd:cd14875    81 ISGESGSGKTENAKMLIAYLGQLSYMHSSNTSQRSIADKIDEnlkwSNPVMESFGNARTVRNDNSSRFGKYIKLYFdPTS 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  269 GMLSSVDIDIYLLEKSRVIFQQAGERNYHIFYQILSG-----QKELHDLllvsANPSDFHFCSCG------AVTVESLDD 337
Cdd:cd14875   161 GVMVGGQTVTYLLEKSRIIMQSPGERNYHIFYEMLAGlspeeKKELGGL----KTAQDYKCLNGGntfvrrGVDGKTLDD 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  338 AEELLATEQAMDILGFLPDEKYGCYKLTGAIMHFGNMKFKQKPREEQLEADGTENAdKAAFLMGINSSELVKCLIhprIK 417
Cdd:cd14875   237 AHEFQNVRHALSMIGVELETQNSIFRVLASILHLMEVEFESDQNDKAQIADETPFL-TACRLLQLDPAKLRECFL---VK 312
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  418 VGNEYVTRGQTIEQVTCAVGALSKSMYERMFKWLVARINRALDAKL--SRQFFIGILDITGFEILEYNSLEQLCINFTNE 495
Cdd:cd14875   313 SKTSLVTILANKTEAEGFRNAFCKAIYVGLFDRLVEFVNASITPQGdcSGCKYIGLLDIFGFENFTRNSFEQLCINYANE 392
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  496 KLQQFFNWHMFVLEQEEYKKESIEWVSIGFGlDLQACIDLIE-KPMGILSILEEECMFPKATDLTFKTKLFDNHFGKSVH 574
Cdd:cd14875   393 SLQNHYNKYTFINDEEECRREGIQIPKIEFP-DNSECVNMFDqKRTGIFSMLDEECNFKGGTTERFTTNLWDQWANKSPY 471
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  575 LQKPK---PDKkkfeahFELVHYAGVVPYNISGWLEKNKDLLNETVVAVFQKSSNRLLASLFenymSTDSaipfGEKKRK 651
Cdd:cd14875   472 FVLPKstiPNQ------FGVNHYAAFVNYNTDEWLEKNTDALKEDMYECVSNSTDEFIRTLL----STEK----GLARRK 537
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  652 kgasfQTVASLHKENLNKLMTNLKSTAPHFVRCINPNVNKIPGILDPYLVLQQLRCNGVLEGTRICREGFPNRLQYADFK 731
Cdd:cd14875   538 -----QTVAIRFQRQLTDLRTELESTETQFIRCIKPNMEASPSFLDNLLVGSQLESAGVLQTIALKRQGYPVRRPIEQFC 612
                         650       660       670       680       690
                  ....*....|....*....|....*....|....*....|....*....|...
gi 767926067  732 QRYCILNPRTfPKSKFVSSR--KAAEELLGS----LEIDHTQYRFGITKVFFK 778
Cdd:cd14875   613 RYFYLIMPRS-TASLFKQEKysEAAKDFLAYyqrlYGWAKPNYAVGKTKVFLR 664
MYSc_Myo25 cd14886
class XXV myosin, motor domain; These myosins are MyTH-FERM myosins that play a role in cell ...
117-778 8.29e-99

class XXV myosin, motor domain; These myosins are MyTH-FERM myosins that play a role in cell adhesion and filopodia formation. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276851  Cd Length: 650  Bit Score: 333.78  E-value: 8.29e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  117 ASVLHTLKRRYGQWMIYTYSGLFCVTINPYKWLP-VYQKEVMAAYKGKRRS-----EAPPHIFAVANNAFQDMLHNRENQ 190
Cdd:cd14886     1 AVVIDILRDRFAKDKIYTYAGKLLVALNPFKQIRnLYGTEVIGRYRQADTSrgfpsDLPPHSYAVAQSALNGLISDGISQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  191 SILFTGESGAGKTVNSKHIIQYFATIAAMiESRKKQGAledqIMQANTILEAFGNAKTLRNDNSSRFGKFIRMHFGARGM 270
Cdd:cd14886    81 SCIVSGESGAGKTETAKQLMNFFAYGHST-SSTDVQSL----ILGSNPLLESFGNAKTLRNNNSSRFGKFIKLLVGPDGG 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  271 LSSVDIDIYLLEKSRVIFQQAGERNYHIFYQILSG----QKELHDLLLVSAnpsdFHFCSCG-AVTVESLDDAEELLATE 345
Cdd:cd14886   156 LKGGKITSYMLELSRIEFQSTNERNYHIFYQCIKGlspeEKKSLGFKSLES----YNFLNASkCYDAPGIDDQKEFAPVR 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  346 QAMDILgFLPDEKYGCYKLTGAIMHFGNMKFKQKPR---EEQLEADGTENADKAAFLMGINSSELVKCLIHPRIKVGNEY 422
Cdd:cd14886   232 SQLEKL-FSKNEIDSFYKCISGILLAGNIEFSEEGDmgvINAAKISNDEDFGKMCELLGIESSKAAQAIITKVVVINNET 310
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  423 VTRGQTIEQVTCAVGALSKSMYERMFKWLVARINRALDAKLSRQFFIGILDITGFEILEYNSLEQLCINFTNEKLQQFFN 502
Cdd:cd14886   311 IISPVTQAQAEVNIRAVAKDLYGALFELCVDTLNEIIQFDADARPWIGILDIYGFEFFERNTYEQLLINYANERLQQYFI 390
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  503 WHMFVLEQEEYKKESIEWVSIGFGlDLQACIDLIEKP-MGILSILEEECMFPKATDLTF----KTKLFDNHFGKSvhlqk 577
Cdd:cd14886   391 NQVFKSEIQEYEIEGIDHSMITFT-DNSNVLAVFDKPnLSIFSFLEEQCLIQTGSSEKFtsscKSKIKNNSFIPG----- 464
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  578 pkpdkKKFEAHFELVHYAGVVPYNISGWLEKNKDLLNETVVAVFQKSSNRLLASLFENYMSTDSAIpfgekkrkKGasfQ 657
Cdd:cd14886   465 -----KGSQCNFTIVHTAATVTYNTEEFVDKNKHKLSVDILELLMGSTNPIVNKAFSDIPNEDGNM--------KG---K 528
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  658 TVASLHKENLNKLMTNLKSTAPHFVRCINPNVNKIPGILDPYLVLQQLRCNGVLEGTRICREGFPNRLQYADFKQRYCIL 737
Cdd:cd14886   529 FLGSTFQLSIDQLMKTLSATKSHFIRCIKTNQDKVPNKYETKSVYNQLISLSIFESIQTIHRGFAYNDTFEEFFHRNKIL 608
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|..
gi 767926067  738 NPRTFPKSKFVSSRKAA-EELLGSLEIDHTQYRFGITKVFFK 778
Cdd:cd14886   609 ISHNSSSQNAGEDLVEAvKSILENLGIPCSDYRIGKTKVFLR 650
MYSc_Myo24A cd14937
class XXIV A myosin, motor domain; These myosins have a 1-2 IQ motifs in their neck and a ...
117-778 2.04e-98

class XXIV A myosin, motor domain; These myosins have a 1-2 IQ motifs in their neck and a coiled-coil region in their C-terminal tail. The function of the class XXIV myosins remain elusive. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276897  Cd Length: 637  Bit Score: 332.36  E-value: 2.04e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  117 ASVLHTLKRRYGQWMIYTYSGLFCVTINPYKWLPVYQKEvmaaYKGKRRSEAPPHIFAVANNAFQDMLHNRENQSILFTG 196
Cdd:cd14937     1 AEVLNMLALRYKKNYIYTIAEPMLISINPYQVIDVDINE----YKNKNTNELPPHVYSYAKDAMTDFINTKTNQSIIISG 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  197 ESGAGKTVNSKHIIQYFatiaamIESRKKQGALEDQIMQANTILEAFGNAKTLRNDNSSRFGKFIRMHFGARGMLSSVDI 276
Cdd:cd14937    77 ESGSGKTEASKLVIKYY------LSGVKEDNEISNTLWDSNFILEAFGNAKTLKNNNSSRYGKYIKIELDEYQNIVSSSI 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  277 DIYLLEKSRVIFQQAGERNYHIFYQILSG-QKELHDLLLVSANpSDFHFCSCGAVTVESLDDAEELLATEQAMDILGfLP 355
Cdd:cd14937   151 EIFLLENIRVVSQEEEERGYHIFYQIFNGmSQELKNKYKIRSE-NEYKYIVNKNVVIPEIDDAKDFGNLMISFDKMN-MH 228
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  356 DEKYGCYKLTGAIMHFGNMKFKQ-----KPREEQLEADGTENADKAAFLMGINSSELVKCLIHPRIKVGNEYVTRGQTIE 430
Cdd:cd14937   229 DMKDDLFLTLSGLLLLGNVEYQEiekggKTNCSELDKNNLELVNEISNLLGINYENLKDCLVFTEKTIANQKIEIPLSVE 308
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  431 QVTCAVGALSKSMYERMFKWLVARINRALDAKLSRQFFIGILDITGFEILEYNSLEQLCINFTNEKLQQFFNWHMFVLEQ 510
Cdd:cd14937   309 ESVSICKSISKDLYNKIFSYITKRINNFLNNNKELNNYIGILDIFGFEIFSKNSLEQLLINIANEEIHSIYLYIVYEKET 388
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  511 EEYKKESIEWVSIGFGLDlQACIDLIEKPMGILSILEEECMFPKATDLTFkTKLFDNHFGKSVHLQKPKPDKKKfeaHFE 590
Cdd:cd14937   389 ELYKAEDILIESVKYTTN-ESIIDLLRGKTSIISILEDSCLGPVKNDESI-VSVYTNKFSKHEKYASTKKDINK---NFV 463
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  591 LVHYAGVVPYNISGWLEKNKDLLNETVVAVFQKSSNRLLASLFENYMSTDSAipfgekKRKKGASFQtvaslHKENLNKL 670
Cdd:cd14937   464 IKHTVSDVTYTITNFISKNKDILPSNIVRLLKVSNNKLVRSLYEDVEVSESL------GRKNLITFK-----YLKNLNNI 532
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  671 MTNLKSTAPHFVRCINPNVNKIPGILDPYLVLQQLRCNGVLEGTRIcREGFPNRLQYADFKQRYCILNPRTFPKSKFVSS 750
Cdd:cd14937   533 ISYLKSTNIYFIKCIKPNENKEKNNFNQKKVFPQLFSLSIIETLNI-SFFFQYKYTFDVFLSYFEYLDYSTSKDSSLTDK 611
                         650       660
                  ....*....|....*....|....*...
gi 767926067  751 RKAAEELLGSLEIDhtQYRFGITKVFFK 778
Cdd:cd14937   612 EKVSMILQNTVDPD--LYKVGKTMVFLK 637
MYSc_Myo16 cd14878
class XVI myosin, motor domain; These XVI type myosins are also known as Neuronal ...
117-778 1.36e-95

class XVI myosin, motor domain; These XVI type myosins are also known as Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 3/NYAP3. Myo16 is thought to play a regulatory role in cell cycle progression and has been recently implicated in Schizophrenia. Class XVI myosins are characterized by an N-terminal ankyrin repeat domain and some with chitin synthase domains that arose independently from the ones in the class XVII fungal myosins. They bind protein phosphatase 1 catalytic subunits 1alpha/PPP1CA and 1gamma/PPP1CC. Human Myo16 interacts with ACOT9, ARHGAP26 and PIK3R2 and with components of the WAVE1 complex, CYFIP1 and NCKAP1. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276844 [Multi-domain]  Cd Length: 656  Bit Score: 324.46  E-value: 1.36e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  117 ASVLHTLKRRYGQWMIYTYSGLFCVTINPYKWLPVYQKEVMAAY---KGKRRSEAPPHIFAVANNAFQDMLHNRENQSIL 193
Cdd:cd14878     1 SSLLYEIQKRFGNNQIYTFIGDILLLVNPYKELPIYSTMVSQLYlssSGQLCSSLPPHLFSCAERAFHQLFQERRPQCFI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  194 FTGESGAGKTVNSKHIIQYFATiaamiESRKKQGALEDQIMQANTILEAFGNAKTLRNDNSSRFGKFIRMHFGAR-GMLS 272
Cdd:cd14878    81 LSGERGSGKTEASKQIMKHLTC-----RASSSRTTFDSRFKHVNCILEAFGHAKTTLNDLSSCFIKYFELQFCERkKHLT 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  273 SVDIDIYLLEKSRVIFQQAGERNYHIFYQILSGQKELHDLLLVSANPSDFHFCSCGA----VTVESLDDAEELLATEQAM 348
Cdd:cd14878   156 GARIYTYMLEKSRLVSQPPGQSNFLIFYLLMDGLSAEEKYGLHLNNLCAHRYLNQTMredvSTAERSLNREKLAVLKQAL 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  349 DILGFLPDEKYGCYKLTGAIMHFGNMKFKQKPREEQLEADGTENADKAAFLMGINSSELVKCLIHPRIKVGNEYVTRGQT 428
Cdd:cd14878   236 NVVGFSSLEVENLFVILSAILHLGDIRFTALTEADSAFVSDLQLLEQVAGMLQVSTDELASALTTDIQYFKGDMIIRRHT 315
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  429 IEQVTCAVGALSKSMYERMFKWLVARINRAL----DAKLSRQFFIGILDITGFEILEYNSLEQLCINFTNEKLQQFFNWH 504
Cdd:cd14878   316 IQIAEFYRDLLAKSLYSRLFSFLVNTVNCCLqsqdEQKSMQTLDIGILDIFGFEEFQKNEFEQLCVNMTNEKMHHYINEV 395
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  505 MFVLEQEEYKKESIEWVSIGFGLDLQACIDLI-EKPMGILSILEEECMFPKATDLTFKTKL---FDNHFGKSVHLQKP-- 578
Cdd:cd14878   396 LFLQEQTECVQEGVTMETAYSPGNQTGVLDFFfQKPSGFLSLLDEESQMIWSVEPNLPKKLqslLESSNTNAVYSPMKdg 475
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  579 --KPDKKKFEAHFELVHYAGVVPYNISGWLEKNKDLLNETVVAVFQKSSNRLLASLFENYMSTdsaipfgekkrkkgasf 656
Cdd:cd14878   476 ngNVALKDQGTAFTVMHYAGRVMYEIVGAIEKNKDSLSQNLLFVMKTSENVVINHLFQSKLVT----------------- 538
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  657 qtVASLHKENLNKLMTNLKSTAPHFVRCINPNVNKIPGILDPYLVLQQLRCNGVLEGTRICREGFPNRLQYADFKQRYCI 736
Cdd:cd14878   539 --IASQLRKSLADIIGKLQKCTPHFIHCIKPNNSKLPDTFDNFYVSAQLQYIGVLEMVKIFRYGYPVRLSFSDFLSRYKP 616
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|....*
gi 767926067  737 LnPRTFPKSKfvssRKAAEELLGSLEIDHTQ---YRFGITKVFFK 778
Cdd:cd14878   617 L-ADTLLGEK----KKQSAEERCRLVLQQCKlqgWQMGVRKVFLK 656
MYSc_Myo37 cd14898
class XXXVII myosin, motor domain; The class XXXVIII myosins are comprised of fungi. Not much ...
118-742 2.22e-92

class XXXVII myosin, motor domain; The class XXXVIII myosins are comprised of fungi. Not much is known about this myosin class. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276863  Cd Length: 578  Bit Score: 312.60  E-value: 2.22e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  118 SVLHTLKRRYGQWMIYTYSGLFCVTINPYKwlPVYQKEVMAAYKgKRRSEAPPHIFAVANNAFQDMLHNrENQSILFTGE 197
Cdd:cd14898     2 ATLEILEKRYASGKIYTKSGLVFLALNPYE--TIYGAGAMKAYL-KNYSHVEPHVYDVAEASVQDLLVH-GNQTIVISGE 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  198 SGAGKTVNSKHIIQYfatiaaMIESRKKQGALEDQIMQANTILEAFGNAKTLRNDNSSRFGKFIRMHFgaRGMLSSVDID 277
Cdd:cd14898    78 SGSGKTENAKLVIKY------LVERTASTTSIEKLITAANLILEAFGNAKTQLNDNSSRFGKRIKLKF--DGKITGAKFE 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  278 IYLLEKSRVIFQQAGERNYHIFYQILSGQkelhDLLLvsanPSDFHFCSCGAVTVESLDD-AEELLATEQAMDILGFLPD 356
Cdd:cd14898   150 TYLLEKSRVTHHEKGERNFHIFYQFCASK----RLNI----KNDFIDTSSTAGNKESIVQlSEKYKMTCSAMKSLGIANF 221
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  357 EKYGCYKLtgAIMHFGNMKFKQkprEEQLEADGTENADKAAFLMGINSSELVKCLIHPRIKVGNEYVTRGQTIEQVTCAV 436
Cdd:cd14898   222 KSIEDCLL--GILYLGSIQFVN---DGILKLQRNESFTEFCKLHNIQEEDFEESLVKFSIQVKGETIEVFNTLKQARTIR 296
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  437 GALSKSMYERMFKWLVARINRALDAKLSRQffIGILDITGFEILEYNSLEQLCINFTNEKLQQFFNWHMFVLEQEEYKKE 516
Cdd:cd14898   297 NSMARLLYSNVFNYITASINNCLEGSGERS--ISVLDIFGFEIFESNGLDQLCINWTNEKIQNDFIKKMFRAKQGMYKEE 374
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  517 SIEWVSIGFgLDLQACIDLIEKPMGILSILEEECMFPKAT--DLTFKTKLFDNHFGKSvhlqkpkpdkkKFEAHFELVHY 594
Cdd:cd14898   375 GIEWPDVEF-FDNNQCIRDFEKPCGLMDLISEESFNAWGNvkNLLVKIKKYLNGFINT-----------KARDKIKVSHY 442
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  595 AGVVPYNISGWLEKNKDllnetvvavfqkssnrllaslfenymsTDSAIPFGEKKRKKGASFQTVASLHKENLNKLMTNL 674
Cdd:cd14898   443 AGDVEYDLRDFLDKNRE---------------------------KGQLLIFKNLLINDEGSKEDLVKYFKDSMNKLLNSI 495
                         570       580       590       600       610       620
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767926067  675 KSTAPHFVRCINPNVNKIPGILDPYLVLQQLRCNGVLEGTRICREGFPNRLQYADFKQRYCILNPRTF 742
Cdd:cd14898   496 NETQAKYIKCIRPNEECRPWCFDRDLVSKQLAECGILETIRLSKQCFPQEIPKDRFEERYRILGITLF 563
MYSc_Myo26 cd14887
class XXVI myosin, motor domain; These MyTH-FERM myosins are thought to be related to the ...
132-778 9.33e-85

class XXVI myosin, motor domain; These MyTH-FERM myosins are thought to be related to the other myosins that have a MyTH4 domain such as class III, VII, IX, X , XV, XVI, XVII, XX, XXII, XXV, and XXXIV. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276852  Cd Length: 725  Bit Score: 295.02  E-value: 9.33e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  132 IYTYSGLFCVTINPYKWLPVYQKEVMAAYKGKRRSEAPPHIFAVANNAFQDMLHNRENQSILFTGESGAGKTVNSKHIIQ 211
Cdd:cd14887    24 IYTYTGTLLIAVNPYRFFNLYDRQWISRFDTEANSRLVPHPFGLAEFAYCRLVRDRRSQSILISGESGAGKTETSKHVLT 103
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  212 YFATIAAMIESRKKQGaLEDQIMQANTILEAFGNAKTLRNDNSSRFGKFIRMHFGARGMLSSVDIDIYLLEKSRVIFQQA 291
Cdd:cd14887   104 YLAAVSDRRHGADSQG-LEARLLQSGPVLEAFGNAHTVLNANSSRFGKMLLLHFTGRGKLTRASVATYLLANERVVRIPS 182
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  292 GERNYHIFYQILSGQK--ELHDLLLVSANPsdfhfcscgavtvESLDdaeeLLATEQAMDILGFLPDEKYGCYKLTGAIM 369
Cdd:cd14887   183 DEFSFHIFYALCNAAVaaATQKSSAGEGDP-------------ESTD----LRRITAAMKTVGIGGGEQADIFKLLAAIL 245
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  370 HFGNMKF--KQKPRE-------------EQLEADGTENADKAAFLMGINSSE--------LVKCLIHPRIKVGNEYV--- 423
Cdd:cd14887   246 HLGNVEFttDQEPETskkrkltsvsvgcEETAADRSHSSEVKCLSSGLKVTEasrkhlktVARLLGLPPGVEGEEMLrla 325
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  424 --------TRGQ-TIEQVTCAVGALSKSMYERMFKWLVARINRAL-------------DAKLSRQF-FIGILDITGFEIL 480
Cdd:cd14887   326 lvsrsvreTRSFfDLDGAAAARDAACKNLYSRAFDAVVARINAGLqrsakpsesdsdeDTPSTTGTqTIGILDLFGFEDL 405
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  481 E---YNSLEQLCINFTNEKLQQFFNWHMFVLEQEEYKKES--IEWVSIGFGLDLQACIDLIEKP---------------- 539
Cdd:cd14887   406 RnhsKNRLEQLCINYANERLHCFLLEQLILNEHMLYTQEGvfQNQDCSAFPFSFPLASTLTSSPsstspfsptpsfrsss 485
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  540 --------MGILSILEEE-CMFPKATDLTFKTKLFDNHFGK----SVHLQKPKPDKKKFEAHFELVHYAGVVPYNISGWL 606
Cdd:cd14887   486 afatspslPSSLSSLSSSlSSSPPVWEGRDNSDLFYEKLNKniinSAKYKNITPALSRENLEFTVSHFACDVTYDARDFC 565
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  607 EKNKDLLNETVVAVFQKSSNRLLaslfENYMSTDSAIPFGEKKRKkgasfqTVASLHKENLNKLMTNLKSTAPHFVRCIN 686
Cdd:cd14887   566 RANREATSDELERLFLACSTYTR----LVGSKKNSGVRAISSRRS------TLSAQFASQLQQVLKALQETSCHFIRCVK 635
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  687 PNVNKIPGILDPYLVLQQLRCNGVLEGTRICREGFPNRLQYADFKQRYCILNPRTFpkSKFVSSRKAAEELLGSLEIDHT 766
Cdd:cd14887   636 PNRVQEAGIFEDAYVHRQLRCSGMSDLLRVMADGFPCRLPYVELWRRYETKLPMAL--REALTPKMFCKIVLMFLEINSN 713
                         730
                  ....*....|..
gi 767926067  767 QYRFGITKVFFK 778
Cdd:cd14887   714 SYTFGKTKIFFR 725
MYSc_Myo17 cd14879
class XVII myosin, motor domain; This fungal myosin which is also known as chitin synthase ...
114-777 5.73e-83

class XVII myosin, motor domain; This fungal myosin which is also known as chitin synthase uses its motor domain to tether its vesicular cargo to peripheral actin. It works in opposition to dynein, contributing to the retention of Mcs1 vesicles at the site of cell growth and increasing vesicle fusion necessary for polarized growth. Class 17 myosins consist of a N-terminal myosin motor domain with Cyt-b5, chitin synthase 2, and a DEK_C domains at it C-terminus. The chitin synthase region contains several transmembrane domains by which myosin 17 is thought to bind secretory vesicles. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276845 [Multi-domain]  Cd Length: 647  Bit Score: 287.52  E-value: 5.73e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  114 LNEASVLHTLKRRYGQWMIYTY---SGLfcVTINPYKWLPVYQKEVMAAYK-------GKRRSEAPPHIFAVANNAFQDM 183
Cdd:cd14879     1 PSDDAITSHLASRFRSDLPYTRlgsSAL--VAVNPYKYLSSNSDASLGEYGseyydttSGSKEPLPPHAYDLAARAYLRM 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  184 LHNRENQSILFTGESGAGKTVNSKHIIQYFATIAAmieSRKKQGALEDQIMQANTILEAFGNAKTLRNDNSSRFGKFIRM 263
Cdd:cd14879    79 RRRSEDQAVVFLGETGSGKSESRRLLLRQLLRLSS---HSKKGTKLSSQISAAEFVLDSFGNAKTLTNPNASRFGRYTEL 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  264 HFGARGMLSSVDIDIYLLEKSRVIFQQAGERNYHIFYQILSG-QKELHDLLLVSaNPSDF-----HFCSCGAVTVESlDD 337
Cdd:cd14879   156 QFNERGRLIGAKVLDYRLERSRVASVPTGERNFHVFYYLLAGaSPEERQHLGLD-DPSDYallasYGCHPLPLGPGS-DD 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  338 AEELLATEQAMDILGFLPDEKYGCYKLTGAIMHFGNMKFkqkpreeQLEADGTENA---------DKAAFLMGINSSELV 408
Cdd:cd14879   234 AEGFQELKTALKTLGFKRKHVAQICQLLAAILHLGNLEF-------TYDHEGGEESavvkntdvlDIVAAFLGVSPEDLE 306
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  409 KCLIHpRIKvgneYVTRgqtiEQVTC---AVGA------LSKSMYERMFKWLVARINRALdAKLSRQF--FIGILDITGF 477
Cdd:cd14879   307 TSLTY-KTK----LVRK----ELCTVfldPEGAaaqrdeLARTLYSLLFAWVVETINQKL-CAPEDDFatFISLLDFPGF 376
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  478 EIL---EYNSLEQLCINFTNEKLQQFFNWHMFVLEQEEYKKE--SIEWVSIgfgLDLQACIDLI-EKPMGILSILEEEC- 550
Cdd:cd14879   377 QNRsstGGNSLDQFCVNFANERLHNYVLRSFFERKAEELEAEgvSVPATSY---FDNSDCVRLLrGKPGGLLGILDDQTr 453
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  551 MFPKATDLTFKTKL---FDNHfgKSVHLQKPKPDKKKFeAHFELVHYAGVVPYNISGWLEKNKDLLNETVVavfqkssnr 627
Cdd:cd14879   454 RMPKKTDEQMLEALrkrFGNH--SSFIAVGNFATRSGS-ASFTVNHYAGEVTYSVEGFLERNGDVLSPDFV--------- 521
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  628 llaSLFenymstdsaipfgekkrkKGASFqtvaslHKENLNKLMTNLKSTAPHFVRCINPNVNKIPGILDPYLVLQQLRC 707
Cdd:cd14879   522 ---NLL------------------RGATQ------LNAALSELLDTLDRTRLWSVFCIRPNDSQLPNSFDKRRVKAQIRS 574
                         650       660       670       680       690       700       710
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  708 NGVLEGTRICREGFPNRLQYADFKQRYcilnPRTFPKSKFVSSRKAAEELLGSLEIDhtqYRFGITKVFF 777
Cdd:cd14879   575 LGLPELAARLRVEYVVSLEHAEFCERY----KSTLRGSAAERIRQCARANGWWEGRD---YVLGNTKVFL 637
MYSc_Myo23 cd14884
class XXIII myosin, motor domain; These myosins are predicted to have a neck region with 1-2 ...
117-725 7.32e-75

class XXIII myosin, motor domain; These myosins are predicted to have a neck region with 1-2 IQ motifs and a single MyTH4 domain in its C-terminal tail. The lack of a FERM domain here is odd since MyTH4 domains are usually found alongside FERM domains where they bind to microtubules. At any rate these Class XXIII myosins are still proposed to function in the apicomplexan microtubule cytoskeleton. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276850 [Multi-domain]  Cd Length: 685  Bit Score: 264.85  E-value: 7.32e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  117 ASVLHTLKRRYGQWMIYTYSGLFCVTINPYKWLP-VYQKEVMAAYKGKRRSEA-------PPHIFAVANNAFQDMLHNRE 188
Cdd:cd14884     1 PNVLQNLKNRYLKNKIYTFHASLLLALNPYKPLKeLYDQDVMNVYLHKKSNSAasaapfpKAHIYDIANMAYKNMRGKLK 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  189 NQSILFTGESGAGKTVNSKHIIQYFatiaAMIESRKKQGALEDQIMQANTILEAFGNAKTLRNDNSSRFGKFIRMHFGAR 268
Cdd:cd14884    81 RQTIVVSGHSGSGKTENCKFLFKYF----HYIQTDSQMTERIDKLIYINNILESMSNATTIKNNNSSRCGRINLLIFEEV 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  269 ---------GMLSSVDIDIYLLEKSRVIFQQAGERNYHIFYQILSG--QKELHDLLLVS-------ANPSDFHFCSCGAV 330
Cdd:cd14884   157 entqknmfnGCFRNIKIKILLLEINRCIAHNFGERNFHVFYQVLRGlsDEDLARRNLVRncgvyglLNPDESHQKRSVKG 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  331 TVESLDDAEELLATEQAMDILGF------LPDEKYGCYKLT------GAIMHFGNMKFKQkpreeqleadgtenadkAAF 398
Cdd:cd14884   237 TLRLGSDSLDPSEEEKAKDEKNFvallhgLHYIKYDERQINeffdiiAGILHLGNRAYKA-----------------AAE 299
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  399 LMGINSSELVKCLIHPRIKVGNEYVTRGQTIEQVTCAVGALSKSMYERMFKWLVARINRAL------------DAKLSRQ 466
Cdd:cd14884   300 CLQIEEEDLENVIKYKNIRVSHEVIRTERRKENATSTRDTLIKFIYKKLFNKIIEDINRNVlkckekdesdneDIYSINE 379
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  467 FFIGILDITGFEILEYNSLEQLCINFTNEKLQQFFNWHMFVLEQEEYKKESIEWVSIgfglDLQACIDLIEKPMGILSIL 546
Cdd:cd14884   380 AIISILDIYGFEELSGNDFDQLCINLANEKLNNYYINNEIEKEKRIYARENIICCSD----VAPSYSDTLIFIAKIFRRL 455
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  547 EEECMFP----KATDLTFKTKLFDNH----------FGK-SVHLQKPKPDKKKFEAH-FELVHYAGVVPYNISGWLEKNK 610
Cdd:cd14884   456 DDITKLKnqgqKKTDDHFFRYLLNNErqqqlegkvsYGFvLNHDADGTAKKQNIKKNiFFIRHYAGLVTYRINNWIDKNS 535
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  611 DLLNETVVAVFQKSSNRLLASLFENymstdsaipfgekkrKKGASFQTVASLHKENLNKLMTNLKSTAPHFVRCINPNVN 690
Cdd:cd14884   536 DKIETSIETLISCSSNRFLREANNG---------------GNKGNFLSVSKKYIKELDNLFTQLQSTDMYYIRCFLPNAK 600
                         650       660       670
                  ....*....|....*....|....*....|....*
gi 767926067  691 KIPGILDPYLVLQQLRCNGVLEGTRICREGFPNRL 725
Cdd:cd14884   601 MLPNTFKRLLVYRQLKQCGSNEMIKILNRGLSHKI 635
MYSc_Myo20 cd14881
class XX myosin, motor domain; These class 20 myosins are primarily insect myosins with such ...
118-744 3.48e-73

class XX myosin, motor domain; These class 20 myosins are primarily insect myosins with such members as Drosophila, Daphnia, and mosquitoes. These myosins contain a single IQ motif in the neck region. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276847 [Multi-domain]  Cd Length: 633  Bit Score: 258.12  E-value: 3.48e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  118 SVLHTLKRRYGQWMIYTYSGLFCVTINPYKwlpvyqkEVMAA--YKGKRRSEAPPHIFAVANNAFQDMLHNRENQSILFT 195
Cdd:cd14881     2 AVMKCLQARFYAKEFFTNVGPILLSVNPYR-------DVGNPltLTSTRSSPLAPQLLKVVQEAVRQQSETGYPQAIILS 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  196 GESGAGKTVNSKHIIQYFATIAAmiesrkkqGALEDQIMQ----ANTILEAFGNAKTLRNDNSSRFGKFIRMHFgARGML 271
Cdd:cd14881    75 GTSGSGKTYASMLLLRQLFDVAG--------GGPETDAFKhlaaAFTVLRSLGSAKTATNSESSRIGHFIEVQV-TDGAL 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  272 SSVDIDIYLLEKSRVIFQQAGERNYHIFYQILSG--QKELHDLLLVSANPSDFHFCSCGAVTVESLDDAEELLATEQAMD 349
Cdd:cd14881   146 YRTKIHCYFLDQTRVIRPLPGEKNYHIFYQMLAGlsQEERVKLHLDGYSPANLRYLSHGDTRQNEAEDAARFQAWKACLG 225
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  350 ILG--FLpdekyGCYKLTGAIMHFGNMKFKQKPREEQLEADGTEnADKAAFLMGINSSELVKCLIhprIKVGNeyvTRGQ 427
Cdd:cd14881   226 ILGipFL-----DVVRVLAAVLLLGNVQFIDGGGLEVDVKGETE-LKSVAALLGVSGAALFRGLT---TRTHN---ARGQ 293
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  428 TIEQVtCAVG-------ALSKSMYERMFKWLVARIN--RALDAKLSRQF---FIGILDITGFEILEYNSLEQLCINFTNE 495
Cdd:cd14881   294 LVKSV-CDANmsnmtrdALAKALYCRTVATIVRRANslKRLGSTLGTHAtdgFIGILDMFGFEDPKPSQLEHLCINLCAE 372
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  496 KLQQFFNWHMFVLEQEEYKKESIEW-VSIGFgLDLQACIDLIEK-PMGILSILEEECMfPKATDLTFKTKLFDNHFGKSV 573
Cdd:cd14881   373 TMQHFYNTHIFKSSIESCRDEGIQCeVEVDY-VDNVPCIDLISSlRTGLLSMLDVECS-PRGTAESYVAKIKVQHRQNPR 450
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  574 HLQKPKPDKKKfeahFELVHYAGVVPYNISGWLEKNKDLLNETVVAVFQKSSnrllaslfenymstdsaIPFGekkrkkg 653
Cdd:cd14881   451 LFEAKPQDDRM----FGIRHFAGRVVYDASDFLDTNRDVVPDDLVAVFYKQN-----------------CNFG------- 502
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  654 asFQTVASLHKENLNKLMTNLKSTAPHFVRCINPNVNKIPGILDPYLVLQQLRCNGVLEGTRICREGFPNRLQYADFKQR 733
Cdd:cd14881   503 --FATHTQDFHTRLDNLLRTLVHARPHFVRCIRSNTTETPNHFDRGTVVRQIRSLQVLETVNLMAGGYPHRMRFKAFNAR 580
                         650
                  ....*....|.
gi 767926067  734 YCILNPRTFPK 744
Cdd:cd14881   581 YRLLAPFRLLR 591
MYSc_Myo21 cd14882
class XXI myosin, motor domain; The myosins here are comprised of insects. Leishmania class ...
118-737 4.99e-70

class XXI myosin, motor domain; The myosins here are comprised of insects. Leishmania class XXI myosins do not group with them. Myo21, unlike other myosin proteins, contains UBA-like protein domains and has no structural or functional relationship with the myosins present in other organisms possessing cilia or flagella. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. They have diverse tails with IQ, WW, PX, and Tub domains. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276848  Cd Length: 642  Bit Score: 249.27  E-value: 4.99e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  118 SVLHTLKRRYGQWMIYTYSGLFCVTINPYKWLPVYQKEVMAAYKGKRRSEAPPHIFAVANNAFQDMLHNRENQSILFTGE 197
Cdd:cd14882     2 NILEELRHRYLMGESYTFIGDILLSLNPNEIKQEYPQEFHAKYRCKSRSDNAPHIFSVADSAYQDMLHHEEPQHIILSGE 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  198 SGAGKTVNSKHIIQYFATIAAMiesrkKQGALEdQIMQANTILEAFGNAKTLRNDNSSRFGKFIRMHFGARGMLSSVDID 277
Cdd:cd14882    82 SYSGKTTNARLLIKHLCYLGDG-----NRGATG-RVESSIKAILALVNAGTPLNADSTRCILQYQLTFGSTGKMSGAIFW 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  278 IYLLEKSRVIFQQAGERNYHIFYQI---LSGQKELHDLLL------------VSANPSDFHFC-SCGAVTVESLDDAEEL 341
Cdd:cd14882   156 MYQLEKLRVSTTDGNQSNFHIFYYFydfIEAQNRLKEYNLkagrnyrylripPEVPPSKLKYRrDDPEGNVERYKEFEEI 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  342 LateQAMDilgFLPDEKYGCYKLTGAIMHFGNMKFKQKPREEQLEadGTENADKAAFLMGINSSELVKCLIHPRIKVGNE 421
Cdd:cd14882   236 L---KDLD---FNEEQLETVRKVLAAILNLGEIRFRQNGGYAELE--NTEIASRVAELLRLDEKKFMWALTNYCLIKGGS 307
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  422 YVTRGQTIEQVTCAVGALSKSMYERMFKWLVARINraldAKLS--RQFF-----IGILDITGFEILEYNSLEQLCINFTN 494
Cdd:cd14882   308 AERRKHTTEEARDARDVLASTLYSRLVDWIINRIN----MKMSfpRAVFgdkysISIHDMFGFECFHRNRLEQLMVNTLN 383
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  495 EKLQQFFNWHMFVLEQEEYKKESIEWVSIGFGLDLQACIDLIEKPMGILSILEEECmfpkatdltfKTKLFDNHFGKSVH 574
Cdd:cd14882   384 EQMQYHYNQRIFISEMLEMEEEDIPTINLRFYDNKTAVDQLMTKPDGLFYIIDDAS----------RSCQDQNYIMDRIK 453
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  575 lQKPKPDKKKFEAH-FELVHYAGVVPYNISGWLEKNKDLLNETVVAVFQKSSNRLLASLFENYMStdsaipfgEKKRKKG 653
Cdd:cd14882   454 -EKHSQFVKKHSAHeFSVAHYTGRIIYDAREFADKNRDFVPPEMIETMRSSLDESVKLMFTNSQV--------RNMRTLA 524
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  654 ASFQTvASLhkENLNKLMTNLKSTAPHFVRCINPNVNKIPGILDPYLVLQQLRCNGVLEGTRICREGFPNRLQYADFKQR 733
Cdd:cd14882   525 ATFRA-TSL--ELLKMLSIGANSGGTHFVRCIRSDLEYKPRGFHSEVVRQQMRALAVLDTAKARQKGFSYRIPFQEFLRR 601

                  ....
gi 767926067  734 YCIL 737
Cdd:cd14882   602 YQFL 605
MYSc_Myo44 cd14905
class XLIV myosin, motor domain; There is little known about the function of the myosin XLIV ...
118-742 3.20e-68

class XLIV myosin, motor domain; There is little known about the function of the myosin XLIV class. Members here include cellular slime mold Polysphondylium and soil-living amoeba Dictyostelium. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276870  Cd Length: 673  Bit Score: 244.62  E-value: 3.20e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  118 SVLHTLKRRYGQWMIYTYSGLFCVTINPYKWLPVYQKEVMAAYKGKRRSeAPPHIFAVANNAFQDMLHNRENQSILFTGE 197
Cdd:cd14905     2 TLINIIQARYKKEIIYTYIGPILVSVNPLRYLPFLHSQELVRNYNQRRG-LPPHLFALAAKAISDMQDFRRDQLIFIGGE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  198 SGAGKTVNSKHIIQYFATIAAmieSRKKQgaLEDQIMQANTILEAFGNAKTLRNDNSSRFGKFIRMHFGARGMLSSVDID 277
Cdd:cd14905    81 SGSGKSENTKIIIQYLLTTDL---SRSKY--LRDYILESGIILESFGHASTDSNHNSSRWGKYFEMFYSLYGEIQGAKLY 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  278 IYLLEKSRVIFQQAGERNYHIFYQILSGQKELHDLLLVSANPSDFHFCS-CGAVTVESLDDAEELLATEQAMDILGFlPD 356
Cdd:cd14905   156 SYFLDENRVTYQNKGERNFHIFYQFLKGITDEEKAAYQLGDINSYHYLNqGGSISVESIDDNRVFDRLKMSFVFFDF-PS 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  357 EKYG-CYKLTGAIMHFGNMKFKQKprEEQLEADGTENADKAAFLMGINSSELVKCLIHPRIKVGNEYVTRGQTieqvtca 435
Cdd:cd14905   235 EKIDlIFKTLSFIIILGNVTFFQK--NGKTEVKDRTLIESLSHNITFDSTKLENILISDRSMPVNEAVENRDS------- 305
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  436 vgaLSKSMYERMFKWLVARINRALDAKlSRQFFIGILDITGFEILEYNSLEQLCINFTNEKLQQFFNWHMFVLEQEEYKK 515
Cdd:cd14905   306 ---LARSLYSALFHWIIDFLNSKLKPT-QYSHTLGILDLFGQESSQLNGYEQFSINFLEERLQQIYLQTVLKQEQREYQT 381
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  516 ESIEWVS-IGFGlDLQACIDLIEKpmgILSILEEECMFPKATDLTFKTKLfdNHFGKSVHLQKPKPDKkkfeahFELVHY 594
Cdd:cd14905   382 ERIPWMTpISFK-DNEESVEMMEK---IINLLDQESKNINSSDQIFLEKL--QNFLSRHHLFGKKPNK------FGIEHY 449
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  595 AGVVPYNISGWLEKNKDL-------------------------LNETVVAVFQ-----KSSNRLLASLFENYMSTDSAIP 644
Cdd:cd14905   450 FGQFYYDVRGFIIKNRDEilqrtnvlhknsitkylfsrdgvfnINATVAELNQmfdakNTAKKSPLSIVKVLLSCGSNNP 529
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  645 ------------------FGEKKRKKGASFQTVASLHKEnlnklmTNLKSTAPHFVRCINPNVNKIPGILDPYLVLQQLR 706
Cdd:cd14905   530 nnvnnpnnnsgggggggnSGGGSGSGGSTYTTYSSTNKA------INNSNCDFHFIRCIKPNSKKTHLTFDVKSVNEQIK 603
                         650       660       670
                  ....*....|....*....|....*....|....*...
gi 767926067  707 CNGVLEGTRICREGFPNRLQYADFKQRYCIL--NPRTF 742
Cdd:cd14905   604 SLCLLETTRIQRFGYTIHYNNKIFFDRFSFFfqNQRNF 641
MYSc_Myo12 cd14874
class XXXIII myosin, motor domain; Little is known about the XXXIII class of myosins. They ...
117-737 1.28e-67

class XXXIII myosin, motor domain; Little is known about the XXXIII class of myosins. They are found predominately in nematodes. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276841 [Multi-domain]  Cd Length: 628  Bit Score: 241.70  E-value: 1.28e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  117 ASVLHTLKRRYGQWMIYTYSGLFCVTINPYKWLPVYQKEVMAAYkgkrrseappHIFAVANNAFQDMLHNREN-QSILFT 195
Cdd:cd14874     1 AGIAQNLHERFKKGQTYTKASNVLVFVNDFNKLSIQDQLVIKKC----------HISGVAENALDRIKSMSSNaESIVFG 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  196 GESGAGKTVNSKHIIQYFATIAAMIESRKKQGALEdqimqanTILEAFGNAKTLRNDNSSRFGKFIRMHFgARGMLSSVD 275
Cdd:cd14874    71 GESGSGKSYNAFQVFKYLTSQPKSKVTTKHSSAIE-------SVFKSFGCAKTLKNDEATRFGCSIDLLY-KRNVLTGLN 142
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  276 IDIYL-LEKSRVIFQQAGERNYHIFYQILSGQKELHDLLLVSANPSDFHFCSCGAVTVESLDDAEELLATEQAMDILGFL 354
Cdd:cd14874   143 LKYTVpLEVPRVISQKPGERNFNVFYEVYHGLNDEMKAKFGIKGLQKFFYINQGNSTENIQSDVNHFKHLEDALHVLGFS 222
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  355 PDEKYGCYKLTGAIMHFGNMKFKQKPR---EEQLEADGTENADK-AAFLMGINSSELVKCLIhPRIKVGNEYvtrgqTIE 430
Cdd:cd14874   223 DDHCISIYKIISTILHIGNIYFRTKRNpnvEQDVVEIGNMSEVKwVAFLLEVDFDQLVNFLL-PKSEDGTTI-----DLN 296
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  431 QVTCAVGALSKSMYERMFKWLVARINRALDAKLSRQFfIGILDITGFEILEYNSLEQLCINFTNEKLQQFFNWHMFVLEQ 510
Cdd:cd14874   297 AALDNRDSFAMLIYEELFKWVLNRIGLHLKCPLHTGV-ISILDHYGFEKYNNNGVEEFLINSVNERIENLFVKHSFHDQL 375
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  511 EEYKKESIEwvsigfgLDLQ--ACID-------LIEKPMGILSILEEECMFPKATDLTFKTKLFDNHFGKSVHLQKPKPD 581
Cdd:cd14874   376 VDYAKDGIS-------VDYKvpNSIEngktvelLFKKPYGLLPLLTDECKFPKGSHESYLEHCNLNHTDRSSYGKARNKE 448
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  582 KKKFEAHfelvHYAGVVPYNISGWLEKNKDLLNETVVAVFQKSSNRLLASLFENYMS-TDSAIPFGEKKRKKGAsfQTVA 660
Cdd:cd14874   449 RLEFGVR----HCIGTTWYNVTDFFSRNKRIISLSAVQLLRSSKNPIIGLLFESYSSnTSDMIVSQAQFILRGA--QEIA 522
                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767926067  661 slhkENLNKLMTnlkstapHFVRCINPNVNKIPGILDPYLVLQQLRCNGVLEGTRICREGFPNRLQYADFKQRY-CIL 737
Cdd:cd14874   523 ----DKINGSHA-------HFVRCIKSNNERQPKKFDIPLVNRQIKNLLLAELLSFRIKGYPVKISKTTFARQYrCLL 589
MYSc_Myo32 cd14893
class XXXII myosin, motor domain; Class XXXII myosins do not contain any IQ motifs, but ...
120-777 7.06e-67

class XXXII myosin, motor domain; Class XXXII myosins do not contain any IQ motifs, but possess tandem MyTH4 and FERM domains. The myosin classes XXX to XXXIV contain members from Phytophthora species and Hyaloperonospora parasitica. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276858  Cd Length: 741  Bit Score: 242.57  E-value: 7.06e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  120 LHTLKRRYGQWMIYTYSGLFCVTINPYKWLPVYQKEVMAAYKGKRR----------SEAPPHIFAVANNAFQDMLHNREN 189
Cdd:cd14893     4 LYTLRARYRMEQVYTWVDRVLVGVNPVTPLPIYTPDHMQAYNKSREqtplyekdtvNDAPPHVFALAQNALRCMQDAGED 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  190 QSILFTGESGAGKTVNSKHIIQYFATIAAMIESRK----KQGALE---DQIMQANTILEAFGNAKTLRNDNSSRFGKFIR 262
Cdd:cd14893    84 QAVILLGGMGAGKSEAAKLIVQYLCEIGDETEPRPdsegASGVLHpigQQILHAFTILEAFGNAATRQNRNSSRFAKMIS 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  263 MHFGARGMLSSVDIDIYLLEKSRVIFQQAGERNYHIFYQILSGQKE---LHDLLLVSANPSDFHFCSCGA--VTVESLD- 336
Cdd:cd14893   164 VEFSKHGHVIGGGFTTHYFEKSRVIDCRSHERNFHVFYQVLAGVQHdptLRDSLEMNKCVNEFVMLKQADplATNFALDa 243
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  337 -DAEELLATEQAMDIlgfLPDEKYGCYKLTGAIMHFGNMKFKQKPREEQLEADGTENA----------DKAAFLMGINSS 405
Cdd:cd14893   244 rDYRDLMSSFSALRI---RKNQRVEIVRIVAALLHLGNVDFVPDPEGGKSVGGANSTTvsdaqscalkDPAQILLAAKLL 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  406 ELVKCLIHPRIKV-------GNEYVTRGQ--TIEQVTCAVGALSKSMYERMFKWLVARINRALDAKLSR---------QF 467
Cdd:cd14893   321 EVEPVVLDNYFRTrqffskdGNKTVSSLKvvTVHQARKARDTFVRSLYESLFNFLVETLNGILGGIFDRyeksnivinSQ 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  468 FIGILDITGFEILE--YNSLEQLCINFTNEKLQQFF-------NWHMFVLEQEEYKKESIEWVSIGFGLDLQACIDLIE- 537
Cdd:cd14893   401 GVHVLDMVGFENLTpsQNSFDQLCFNYWSEKVHHFYvqntlaiNFSFLEDESQQVENRLTVNSNVDITSEQEKCLQLFEd 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  538 KPMGILSILEEECMFPKATDLTFKTKLFDNHFGKSVhLQKPKPD----------KKKFEAHFELVHYAGVVPYNISGWLE 607
Cdd:cd14893   481 KPFGIFDLLTENCKVRLPNDEDFVNKLFSGNEAVGG-LSRPNMGadttneylapSKDWRLLFIVQHHCGKVTYNGKGLSS 559
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  608 KNKDLLNETVVAVFQKSSNRLLASLFENYM---STDSAIPFGEKKRKKGASFQTVASLHKENLN--------------KL 670
Cdd:cd14893   560 KNMLSISSTCAAIMQSSKNAVLHAVGAAQMaaaSSEKAAKQTEERGSTSSKFRKSASSARESKNitdsaatdvynqadAL 639
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  671 MTNLKSTAPHFVRCINPNVNKIPGILDPYLVLQQLRCNGVLEGTRICREGFPNRLQYADFKQRYcilnprtfpkSKFVSS 750
Cdd:cd14893   640 LHALNHTGKNFLVCIKPNETLEEGVFDSAYVMKQIRMNHLVELMQASRSIFTVHLTYGHFFRRY----------KNVCGH 709
                         730       740       750
                  ....*....|....*....|....*....|.
gi 767926067  751 RKAAEELLGSLE----IDHTQYRFGITKVFF 777
Cdd:cd14893   710 RGTLESLLRSLSaigvLEEEKFVVGKTKVYL 740
Motor_domain cd01363
Myosin and Kinesin motor domain; Myosin and Kinesin motor domain. These ATPases belong to the ...
139-263 1.70e-52

Myosin and Kinesin motor domain; Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes. Some of the names do not match with what is given in the sequence list. This is because they are based on the current nomenclature by Kollmar/Sebe-Pedros.


Pssm-ID: 276814 [Multi-domain]  Cd Length: 170  Bit Score: 182.16  E-value: 1.70e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  139 FCVTINPYKWLPVY-QKEVMAAYKGKRRSEAPPHIFAVANNAFQDMLHNRENQSILFTGESGAGKTVNSKHIIQYFATIA 217
Cdd:cd01363     1 VLVRVNPFKELPIYrDSKIIVFYRGFRRSESQPHVFAIADPAYQSMLDGYNNQSIFAYGESGAGKTETMKGVIPYLASVA 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 767926067  218 A----------MIESRKKQGALEDQIMQANTILEAFGNAKTLRNDNSSRFGKFIRM 263
Cdd:cd01363    81 FnginkgetegWVYLTEITVTLEDQILQANPILEAFGNAKTTRNENSSRFGKFIEI 136
MYSc_Myo24B cd14938
class XXIV B myosin, motor domain; These myosins have a 1-2 IQ motifs in their neck and a ...
118-776 5.37e-46

class XXIV B myosin, motor domain; These myosins have a 1-2 IQ motifs in their neck and a coiled-coil region in their C-terminal tail. The functions of these myosins remain elusive. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276898 [Multi-domain]  Cd Length: 713  Bit Score: 178.88  E-value: 5.37e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  118 SVLHTLKRRYGQWMIYTYSGLFCVTINPYKWLPVYQKEVMAAYKGKRRSE-APPHIFAVANNAFQDMLHNRENQSILFTG 196
Cdd:cd14938     2 SVLYHLKERFKNNKFYTKMGPLLIFINPKINNNINNEETIEKYKCIDCIEdLSLNEYHVVHNALKNLNELKRNQSIIISG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  197 ESGAGKTVNSKHIIQYFATIAA------------------MIESRKKQGALEDQIMQANTILEAFGNAKTLRNDNSSRFG 258
Cdd:cd14938    82 ESGSGKSEIAKNIINFIAYQVKgsrrlptnlndqeednihNEENTDYQFNMSEMLKHVNVVMEAFGNAKTVKNNNSSRFS 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  259 KFIRMHFGARgMLSSVDIDIYLLEKSRVIFQQAGERNYHIFYQILSGQKELHDLLLVSANPSDFHFCSCGAVTVESLDDA 338
Cdd:cd14938   162 KFCTIHIENE-EIKSFHIKKFLLDKERLINRKANENSFNIFYYIINGSSDKFKKMYFLKNIENYSMLNNEKGFEKFSDYS 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  339 EELLATEQAMDILGFLPDEKYGCYKLTGAIMHFGNMKFKQKPREEQL-----------------------EADGTENADK 395
Cdd:cd14938   241 GKILELLKSLNYIFDDDKEIDFIFSVLSALLLLGNTEIVKAFRKKSLlmgknqcgqninyetilselensEDIGLDENVK 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  396 ----AAFLMGINSSELVKCLIHPRIkVGNEYVTRGQTIEQVTCAVGALSKSMYERMFKWLVARINRALDAKLSRQFF--- 468
Cdd:cd14938   321 nlllACKLLSFDIETFVKYFTTNYI-FNDSILIKVHNETKIQKKLENFIKTCYEELFNWIIYKINEKCTQLQNININtny 399
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  469 IGILDITGFEILEYNSLEQLCINFTNEKLQQFFNWHMFVLEQEEYKKESIEWVSIGFGLDLQACID-LIEKPMGILSILE 547
Cdd:cd14938   400 INVLDMAYFENSKDNSLEQLLINTTNEEIIKIKNDCLYKKRVLSYNEDGIFCEYNSENIDNEPLYNlLVGPTEGSLFSLL 479
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  548 EECMFPKATDLTFKTKLFDNHFGKSVHLQKpKPDKKKFEAHFELVHYAGVVPYNISGWLEKNKDLLNETVVAVFQKSSNR 627
Cdd:cd14938   480 ENVSTKTIFDKSNLHSSIIRKFSRNSKYIK-KDDITGNKKTFVITHSCGDIIYNAENFVEKNIDILTNRFIDMVKQSENE 558
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  628 LLASL--FENYMSTDS--------AIPFGEK--KRKKGASFQTVASLHKENLNKLMTNLKSTAPHFVRCINPNVNK-IPG 694
Cdd:cd14938   559 YMRQFcmFYNYDNSGNiveekrrySIQSALKlfKRRYDTKNQMAVSLLRNNLTELEKLQETTFCHFIVCMKPNESKrELC 638
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  695 ILDPYLVLQQLRCNGVLEGTRICREGFPNRLQYADFKQRYCILNPrtfpkskfvSSRKAAEELLGSLEIDHTQYRFGITK 774
Cdd:cd14938   639 SFDANIVLRQVRNFSIVEASQLKVGYYPHKFTLNEFLSIFDIKNE---------DLKEKVEALIKSYQISNYEWMIGNNM 709

                  ..
gi 767926067  775 VF 776
Cdd:cd14938   710 IF 711
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
869-1759 4.24e-30

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 130.56  E-value: 4.24e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   869 AQLQKAlEKSEFQREELKAKQVSL-TQEKNDLILQLQAEQETLANVEEQCEwlikskiQLEARVKELSERVEEEEEINSE 947
Cdd:TIGR02168  207 RQAEKA-ERYKELKAELRELELALlVLRLEELREELEELQEELKEAEEELE-------ELTAELQELEEKLEELRLEVSE 278
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   948 LTARGRKLEDECFELKKEIDDLETMLVKSEKEKRTTEHKVKNLTEEVEFLNEDISKLNRAAKVVQEAHQQTLDDLHMEEE 1027
Cdd:TIGR02168  279 LEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEA 358
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1028 KLSSLSKANLKLEQQVDELEGALEQERKARMNCERELHKLEGNLKLNRESMENLESSQRHLAEELRKKELELsqmnskve 1107
Cdd:TIGR02168  359 ELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKL-------- 430
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1108 nEKGLVAQLQKTVKELQTQIKDLKEKLEAERTTRAKMERERADLTQDLADLNERLEEVGgsslAQLEITKKQETKFQKLH 1187
Cdd:TIGR02168  431 -EEAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQ----ARLDSLERLQENLEGFS 505
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1188 RDMEEATLhfettsaslkkrHADSLAELEGQVENLQQVKQKLEKDKS-DLQLEVDDLLtrVEQMTRAKANAEKLctlyee 1266
Cdd:TIGR02168  506 EGVKALLK------------NQSGLSGILGVLSELISVDEGYEAAIEaALGGRLQAVV--VENLNAAKKAIAFL------ 565
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1267 rlheATAKLDKVTQLANDLAAQkTKLWSESGEFLRRLEEKEALINQLSREKSNFTRQIEDLRGQLeketksqsALAHALQ 1346
Cdd:TIGR02168  566 ----KQNELGRVTFLPLDSIKG-TEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSYLLGGV--------LVVDDLD 632
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1347 KAQRdcdLLREQYEEEQEVKAELHRTL---------SKVNAEMVQWRMKYENNViQRTEDLEDAKKELAIRLQEAAEAMG 1417
Cdd:TIGR02168  633 NALE---LAKKLRPGYRIVTLDGDLVRpggvitggsAKTNSSILERRREIEELE-EKIEELEEKIAELEKALAELRKELE 708
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1418 VANARNASLERARHQLQLELGDALSDLGKVRSAAARLDQKQLQSGKALADWKQKHEESQALLDASQKEVQALSTELLKLK 1497
Cdd:TIGR02168  709 ELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELE 788
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1498 NTYEESIVGQETLRRENKNLQEEISNLTNQVREGTKNLTEMEKVKKLIEEEKTEVQVTLEETEGALERNESKILHFQLEL 1577
Cdd:TIGR02168  789 AQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELI 868
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1578 LEAKAELERKLSEKDEEIENfrrkqqctIDSLQSSLDSEAKSRIEVTRLKKKMEEDLNEMELQLSCANRQVSEATKSLGQ 1657
Cdd:TIGR02168  869 EELESELEALLNERASLEEA--------LALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDN 940
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1658 LQIQIKDL-QMQLDDSTQLNSDLKEQVAVAERRNSLLQSELEDLRSLQEqtergrrLSEEELLEATERINLFYTQNTSLL 1736
Cdd:TIGR02168  941 LQERLSEEySLTLEEAEALENKIEDDEEEARRRLKRLENKIKELGPVNL-------AAIEEYEELKERYDFLTAQKEDLT 1013
                          890       900
                   ....*....|....*....|...
gi 767926067  1737 SQKKKLEADVARMQKEAEEVVQE 1759
Cdd:TIGR02168 1014 EAKETLEEAIEEIDREARERFKD 1036
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
1093-1932 2.35e-29

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 128.25  E-value: 2.35e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1093 RKKELElSQMNSKVENekglVAQLQKTVKELQTQIKDLKEKLE-AERTTRAKMERERADLTQDLADLNERLEEVggssLA 1171
Cdd:TIGR02168  173 RRKETE-RKLERTREN----LDRLEDILNELERQLKSLERQAEkAERYKELKAELRELELALLVLRLEELREEL----EE 243
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1172 QLEITKKQETKFQKLHRDMEEATLHFETTSASLKKRHaDSLAELEGQVENLQQVKQKLEKDKSDLQLEVDDLLTRVEQMT 1251
Cdd:TIGR02168  244 LQEELKEAEEELEELTAELQELEEKLEELRLEVSELE-EEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELE 322
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1252 RAKANAEKLCTLYEERLHEATAKLDKVTQLANDLAAQKTKLWSESGEFLRRLEEKEALINQLSREKSNFTRQIEDLRGQL 1331
Cdd:TIGR02168  323 AQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEI 402
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1332 EKETKSQSALAHALQKAQRDCDLLREQYEEEQevKAELHRTLSKVNAEMVQWRMKYEnNVIQRTEDLEDAKKELAIRLQE 1411
Cdd:TIGR02168  403 ERLEARLERLEDRRERLQQEIEELLKKLEEAE--LKELQAELEELEEELEELQEELE-RLEEALEELREELEEAEQALDA 479
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1412 AAEAMGVANARNASLERARHQLQlelgdalsdlGKVRSAAARLDQKQLQSGkaladwkqkheesqalldasqkeVQALST 1491
Cdd:TIGR02168  480 AERELAQLQARLDSLERLQENLE----------GFSEGVKALLKNQSGLSG-----------------------ILGVLS 526
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1492 ELLKLKNTYEESIvgqETLRREnkNLQEEISNLTNQVREGTKNLTEMEKVKKLIEEEKTEVQVTLEETEGALERNESKIL 1571
Cdd:TIGR02168  527 ELISVDEGYEAAI---EAALGG--RLQAVVVENLNAAKKAIAFLKQNELGRVTFLPLDSIKGTEIQGNDREILKNIEGFL 601
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1572 HFQLELLEAKAELERKLS----------EKDEEIENFRR-KQQCTIDSLQSSL-----------DSEAKSRIEVTRLKKK 1629
Cdd:TIGR02168  602 GVAKDLVKFDPKLRKALSyllggvlvvdDLDNALELAKKlRPGYRIVTLDGDLvrpggvitggsAKTNSSILERRREIEE 681
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1630 MEEDLNEMELQLSCANRQVSEATKSLGQLQIQIKDLQMQLDDSTQLNSDLKEQVAVAERRNSLLQSELEDLRSLQEQTER 1709
Cdd:TIGR02168  682 LEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEA 761
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1710 GRRLSEEELLEATERInlfytqnTSLLSQKKKLEADVARMQKEAEEVVQECQNAEEKAKKAAIEAANLSEELKKKQDTIA 1789
Cdd:TIGR02168  762 EIEELEERLEEAEEEL-------AEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIA 834
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1790 HLERTRENMEQTITDLQKRLAEAE------QMALMGSRKQIQKLESRVRELEGELEGEIRRSAEAQRGARRLERCIKELT 1863
Cdd:TIGR02168  835 ATERRLEDLEEQIEELSEDIESLAaeieelEELIEELESELEALLNERASLEEALALLRSELEELSEELRELESKRSELR 914
                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1864 YQAEEDKKNLSRMQTQMDKLQLKVQNYKQQV-EVAETQANQYLSKYKKQQHELNEVKERAEVAESQVNKL 1932
Cdd:TIGR02168  915 RELEELREKLAQLELRLEGLEVRIDNLQERLsEEYSLTLEEAEALENKIEDDEEEARRRLKRLENKIKEL 984
MYSc_Myo33 cd14894
class myosin, motor domain; Class XXXIII myosins have variable numbers of IQ domain and 2 ...
233-718 4.12e-24

class myosin, motor domain; Class XXXIII myosins have variable numbers of IQ domain and 2 tandem ANK repeats that are separated by a PH domain. The myosin classes XXX to XXXIV contain members from Phytophthora species and Hyaloperonospora parasitica. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276859 [Multi-domain]  Cd Length: 871  Bit Score: 110.60  E-value: 4.12e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  233 IMQANTILEAFGNAKTLRNDNSSRFGKF--IRMHFGARG---MLSSVDIDIYLLEKSRVIFQQA------GERNYHIFYQ 301
Cdd:cd14894   249 VLDSNIVLEAFGHATTSMNLNSSRFGKMttLQVAFGLHPwefQICGCHISPFLLEKSRVTSERGresgdqNELNFHILYA 328
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  302 ILSG----------QKELH-DLLLVSA----NPSDFHFCscGAVTVESL--DDAEELLATEQAMDILGFLPDEKYGCYKL 364
Cdd:cd14894   329 MVAGvnafpfmrllAKELHlDGIDCSAltylGRSDHKLA--GFVSKEDTwkKDVERWQQVIDGLDELNVSPDEQKTIFKV 406
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  365 TGAIMHFGNMKFKQKPREEQL--EADGTENA-DKAAFLMGINSSE-LVKCLIHPRIKVGNEYVTRGQTIE--QVTCAVGA 438
Cdd:cd14894   407 LSAVLWLGNIELDYREVSGKLvmSSTGALNApQKVVELLELGSVEkLERMLMTKSVSLQSTSETFEVTLEkgQVNHVRDT 486
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  439 LSKSMYERMFKWLVARINRA--------------LDAKLSRQ---FFIGILDITGFEILEYNSLEQLCINFTNEKLQqff 501
Cdd:cd14894   487 LARLLYQLAFNYVVFVMNEAtkmsalstdgnkhqMDSNASAPeavSLLKIVDVFGFEDLTHNSLDQLCINYLSEKLY--- 563
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  502 nwhmfvleQEEYKKESIEWVSIGFGLDLQACIDLI---EKPMGILSILEEECMFPKATDLTF-----KTKLFDNHFGKSV 573
Cdd:cd14894   564 --------AREEQVIAVAYSSRPHLTARDSEKDVLfiyEHPLGVFASLEELTILHQSENMNAqqeekRNKLFVRNIYDRN 635
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  574 HLQKPKPDKKKFEAH-----------FELVHYAGVVPYNISGWLEKNKDLLNETVVAVFQKSSNRLLASLFENYM----- 637
Cdd:cd14894   636 SSRLPEPPRVLSNAKrhtpvllnvlpFVIPHTRGNVIYDANDFVKKNSDFVYANLLVGLKTSNSSHFCRMLNESSqlgws 715
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  638 -STDSAIPFGEKKRKKGAsfQTVASLHKENLNKLMTNLKSTAPHFVRCINPNVNKIPGILDPYLVLQQLRCNGVLEGTRI 716
Cdd:cd14894   716 pNTNRSMLGSAESRLSGT--KSFVGQFRSHVNVLTSQDDKNMPFYFHCIRPNAKKQPSLVNNDLVEQQCRSQRLIRQMEI 793

                  ..
gi 767926067  717 CR 718
Cdd:cd14894   794 CR 795
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
961-1815 1.74e-20

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 99.37  E-value: 1.74e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   961 ELKKEIDDLE-TMLVKS----EKEKRTTEHKVKNLTEEVEFLNEDISKLNRAAkvvqEAHQQTLDDLHMEEEKLSSLSKA 1035
Cdd:TIGR02169  215 ALLKEKREYEgYELLKEkealERQKEAIERQLASLEEELEKLTEEISELEKRL----EEIEQLLEELNKKIKDLGEEEQL 290
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1036 NLKleQQVDELEGALEQerkarmncerelhkLEGNLKLNRESMENLESSQRHLAEELRKKELELSQMNSKVENEKGLVAQ 1115
Cdd:TIGR02169  291 RVK--EKIGELEAEIAS--------------LERSIAEKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDK 354
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1116 LQKTVKELQTQIKDLKEKLEAERTTRAKMERERADLTQDLADLNERLEEVGGSSLAQLEITKKQETKFQKLHRDM---EE 1192
Cdd:TIGR02169  355 LTEEYAELKEELEDLRAELEEVDKEFAETRDELKDYREKLEKLKREINELKRELDRLQEELQRLSEELADLNAAIagiEA 434
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1193 ATLHFETTsaslKKRHADSLAELEGQVENLQQVKQKLEKDKSDLQLEVDDLltrveqmtrakanaeklctlyEERLHEAT 1272
Cdd:TIGR02169  435 KINELEEE----KEDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDRV---------------------EKELSKLQ 489
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1273 AKLDKvtqlandLAAQKTKLWSESGEFLRRLEEKEA-------LINQLSREKSNFTRQIEdlrgqleketksqSALAHAL 1345
Cdd:TIGR02169  490 RELAE-------AEAQARASEERVRGGRAVEEVLKAsiqgvhgTVAQLGSVGERYATAIE-------------VAAGNRL 549
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1346 QKAQRDCDLLRE---QYEEEQEVKAELHRTLSKVNAEMVQWRMKYENNVIQRTEDLEDAKKELAI-------------RL 1409
Cdd:TIGR02169  550 NNVVVEDDAVAKeaiELLKRRKAGRATFLPLNKMRDERRDLSILSEDGVIGFAVDLVEFDPKYEPafkyvfgdtlvveDI 629
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1410 QEAAEAMGvaNARNASLE--------------RARHQLQlelGDALSDLGKVRSAAARLDQKQlqsgKALADWKQKHEES 1475
Cdd:TIGR02169  630 EAARRLMG--KYRMVTLEgelfeksgamtggsRAPRGGI---LFSRSEPAELQRLRERLEGLK----RELSSLQSELRRI 700
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1476 QALLDASQKEVQALSTELLKLKNTYEESIVGQETLRRENKNLQEEISNLtnqvregtknltemekvkkliEEEKTEVQVT 1555
Cdd:TIGR02169  701 ENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSL---------------------EQEIENVKSE 759
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1556 LEETEGALERNESKILHFQLELleakAELERKLS-EKDEEIENFRRKQQCTIDSLQSSLDSeaksrievtrlkkkMEEDL 1634
Cdd:TIGR02169  760 LKELEARIEELEEDLHKLEEAL----NDLEARLShSRIPEIQAELSKLEEEVSRIEARLRE--------------IEQKL 821
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1635 NEMELQLSCANRQVSEATKSLGQLQIQIKDLQMQLDDSTQLNSDLKEQVAVAERRNSLLQSELEDLRS----LQEQ---T 1707
Cdd:TIGR02169  822 NRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEELEAALRDLESRLGDLKKerdeLEAQlreL 901
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1708 ERGRRLSEEELLEATERINLFYTQNTSLLSQKKKLEADVARMQKEAEE------VVQECQNAEEKAKKAAIEAANLSEEL 1781
Cdd:TIGR02169  902 ERKIEELEAQIEKKRKRLSELKAKLEALEEELSEIEDPKGEDEEIPEEelsledVQAELQRVEEEIRALEPVNMLAIQEY 981
                          890       900       910
                   ....*....|....*....|....*....|....
gi 767926067  1782 KKKQDTIAHLERTRENMEQTITDLQKRLAEAEQM 1815
Cdd:TIGR02169  982 EEVLKRLDELKEKRAKLEEERKAILERIEEYEKK 1015
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
859-1756 2.72e-20

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 98.60  E-value: 2.72e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   859 EEVAGLKEECAQLQKALEKSEFQREELKAKQvSLTQEKNDLILQLQAEQETLanveEQCEWLIKSKIQLEARVKELSERv 938
Cdd:TIGR02169  160 DEIAGVAEFDRKKEKALEELEEVEENIERLD-LIIDEKRQQLERLRREREKA----ERYQALLKEKREYEGYELLKEKE- 233
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   939 eeeeeinsELTARGRKLEDECFELKKEIDDLETMLVKSEKEKRTTEHKVKNLTEEVEFLNEDISklnraakvvqeahqqt 1018
Cdd:TIGR02169  234 --------ALERQKEAIERQLASLEEELEKLTEEISELEKRLEEIEQLLEELNKKIKDLGEEEQ---------------- 289
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1019 lddlhmeeeklsslskanLKLEQQVDELEGALEQerkarmncerelhkLEGNLKLNRESMENLESSQRHLAEELRKKELE 1098
Cdd:TIGR02169  290 ------------------LRVKEKIGELEAEIAS--------------LERSIAEKERELEDAEERLAKLEAEIDKLLAE 337
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1099 LSQMNSKVENEKGLVAQLQKTVKELQTQIKDLKEKLEAERTTRAKMERERADLTQDLADLNERLEEVGGSSLAQLEITKK 1178
Cdd:TIGR02169  338 IEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETRDELKDYREKLEKLKREINELKRELDRLQEELQR 417
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1179 QETKFQKLHRDM---EEATLHFETTsaslKKRHADSLAELEGQVENLQQVKQKLEKDKSDLQLEVDDLltrveqmtraka 1255
Cdd:TIGR02169  418 LSEELADLNAAIagiEAKINELEEE----KEDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDRV------------ 481
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1256 naeklctlyEERLHEATAKLDKvtqlandLAAQKTKLWSESGEFLRRLEEKEA-------LINQLSREKSNFTRQIEDLR 1328
Cdd:TIGR02169  482 ---------EKELSKLQRELAE-------AEAQARASEERVRGGRAVEEVLKAsiqgvhgTVAQLGSVGERYATAIEVAA 545
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1329 GQ------LEKETKSQSALAHALQ-KAQRDCDL-LREQYEEEQEVKAELHRTLSKVNAEMVQWRMKYENN---VIQRT-- 1395
Cdd:TIGR02169  546 GNrlnnvvVEDDAVAKEAIELLKRrKAGRATFLpLNKMRDERRDLSILSEDGVIGFAVDLVEFDPKYEPAfkyVFGDTlv 625
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1396 -EDLEDAKK--------ELAIRLQEAAEAM-----------GVANARNASLERARHQLQlELGDALSDL-GKVRSAAARL 1454
Cdd:TIGR02169  626 vEDIEAARRlmgkyrmvTLEGELFEKSGAMtggsraprggiLFSRSEPAELQRLRERLE-GLKRELSSLqSELRRIENRL 704
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1455 DQKQlqsgKALADWKQKHEESQALLDASQKEVQALSTELLKLKNTYEESIVGQETLRRENKNLQEEISNLTNQVREGTKN 1534
Cdd:TIGR02169  705 DELS----QELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEEA 780
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1535 LTEMEkvKKLIEEEKTEVQVTLEETEGALERNESKILHFQLElLEAKAELERKLSEKDEEIENFRRKQQCTIDSLQSSLD 1614
Cdd:TIGR02169  781 LNDLE--ARLSHSRIPEIQAELSKLEEEVSRIEARLREIEQK-LNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIE 857
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1615 SEAKSRIEVTRLKKKMEEDLNEMELQLSCANRQVSEATKSLGQLQIQIKDLQMQLDDSTQLNSDLKEQVAVAERRNSLLQ 1694
Cdd:TIGR02169  858 NLNGKKEELEEELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAKLEALEEELSEIE 937
                          890       900       910       920       930       940       950
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767926067  1695 ----------SELEDLRSLQEQTERgrrlsEEELLEATERINLFYTQN-TSLLSQKKKLEADVARMQKEAEEV 1756
Cdd:TIGR02169  938 dpkgedeeipEEELSLEDVQAELQR-----VEEEIRALEPVNMLAIQEyEEVLKRLDELKEKRAKLEEERKAI 1005
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
856-1597 9.57e-19

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 93.58  E-value: 9.57e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   856 EVGEEVAGLKEECAQLQKALEKSEFQREELKAKQVSLTQekndlilQLQAEQETLANVEEQCEWLIKSKIQLEARVKELS 935
Cdd:TIGR02168  341 ELEEKLEELKEELESLEAELEELEAELEELESRLEELEE-------QLETLRSKVAQLELQIASLNNEIERLEARLERLE 413
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   936 ERVEEEEEINSELtaRGRKLEDECFELKKEIDDLETMLVKSEKEKRTTEHKVKNLTEEVEFLNEDISKLNRAAkvvqEAH 1015
Cdd:TIGR02168  414 DRRERLQQEIEEL--LKKLEEAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAEREL----AQL 487
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1016 QQTLDDLHMEEEKLSSLSKANLKLEQQVDELEGALEQeRKARMNCERELHK-LEGNLklnRESMENLESsqrhlaeelRK 1094
Cdd:TIGR02168  488 QARLDSLERLQENLEGFSEGVKALLKNQSGLSGILGV-LSELISVDEGYEAaIEAAL---GGRLQAVVV---------EN 554
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1095 KELELSQMNSKVENEKGLVAQLqktvkeLQTQIKDlkEKLEAERTTRAKMERERADLTQDLADLNERLEEVGGSSLAQLE 1174
Cdd:TIGR02168  555 LNAAKKAIAFLKQNELGRVTFL------PLDSIKG--TEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSYLLGGVL 626
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1175 ITKKQETKFQKLHRDMEEATL-----------------HFETTSASLKKR-----HADSLAELEGQVENLQQVKQKLEKD 1232
Cdd:TIGR02168  627 VVDDLDNALELAKKLRPGYRIvtldgdlvrpggvitggSAKTNSSILERRreieeLEEKIEELEEKIAELEKALAELRKE 706
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1233 KSDLQLEVDDLLTRVEQMTRA-------KANAEKLCTLYEERLHEATAKLDKVTQLANDLAAQKTKLWSESGEFLRRLEE 1305
Cdd:TIGR02168  707 LEELEEELEQLRKELEELSRQisalrkdLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEE 786
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1306 KEALINQLSREKSNFTRQIEDLRGQLEKETKSQSALAHALQKAQRDCDLLREQYEEEQEVKAELHRTLSKVNAEMvqwrm 1385
Cdd:TIGR02168  787 LEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEI----- 861
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1386 kyennviqrtEDLEDAKKELAIRLQEAAEAMgvanarnASLERARHQLQLELGDALSDLGKVRSAAARLDQKQLQSGKAL 1465
Cdd:TIGR02168  862 ----------EELEELIEELESELEALLNER-------ASLEEALALLRSELEELSEELRELESKRSELRRELEELREKL 924
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1466 ADWKQKHEESQALLDASQKEVQAL-STELLKLKNTYEESIVGQETLRRENKNLQEEISNLtnqvreGTKNLTEMEKvkkl 1544
Cdd:TIGR02168  925 AQLELRLEGLEVRIDNLQERLSEEySLTLEEAEALENKIEDDEEEARRRLKRLENKIKEL------GPVNLAAIEE---- 994
                          730       740       750       760       770
                   ....*....|....*....|....*....|....*....|....*....|...
gi 767926067  1545 IEEEKTEVQVTLEETEgalerneskilhfqlELLEAKAELERKLSEKDEEIEN 1597
Cdd:TIGR02168  995 YEELKERYDFLTAQKE---------------DLTEAKETLEEAIEEIDREARE 1032
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
855-1601 4.62e-18

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 91.28  E-value: 4.62e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   855 SEVGEEVAGLKEECAQLQKALEKSEFQREELKAKQVSLTQEK----NDLILQLQAEQE----TLANVEEQCEWLIKSKIQ 926
Cdd:TIGR02169  247 ASLEEELEKLTEEISELEKRLEEIEQLLEELNKKIKDLGEEEqlrvKEKIGELEAEIAslerSIAEKERELEDAEERLAK 326
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   927 LEARVKELSERVEEEEEINSELTARGRKLEDECFELKKEIDDLETMLVKSEKEKRTTEHKVKNLTEEVEFLNEDISKLNR 1006
Cdd:TIGR02169  327 LEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETRDELKDYREKLEKLKREINELKR 406
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1007 AAKVVQEAHQQTLDDLHMEEEKLSSLskanlklEQQVDELEGALEQERKARMNCERELHKLEGNLKLNRESMENLESSQR 1086
Cdd:TIGR02169  407 ELDRLQEELQRLSEELADLNAAIAGI-------EAKINELEEEKEDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEYD 479
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1087 HLAEELRKKELELSQ---------------------MNSKVENEKGLVAQLQKTVKELQTQI------------------ 1127
Cdd:TIGR02169  480 RVEKELSKLQRELAEaeaqaraseervrggraveevLKASIQGVHGTVAQLGSVGERYATAIevaagnrlnnvvveddav 559
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1128 -KDLKEKLEAERTTRA------KMERERADLTQ-----------DLADLNERLEE----VGGSSLA--QLEITKKQETKF 1183
Cdd:TIGR02169  560 aKEAIELLKRRKAGRAtflplnKMRDERRDLSIlsedgvigfavDLVEFDPKYEPafkyVFGDTLVveDIEAARRLMGKY 639
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1184 QKLHRDMEEATLHFETTSASLKKRHADSLA-ELEGQVENLQQVKQKLEKDKSDLQLEVDDLltrveqmtrakanaeklct 1262
Cdd:TIGR02169  640 RMVTLEGELFEKSGAMTGGSRAPRGGILFSrSEPAELQRLRERLEGLKRELSSLQSELRRI------------------- 700
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1263 lyEERLHEATAKLDKVTQLANDLAAQKTKLWSESGEFLRRLEEKEALINQLSREKSNFTRQIEDLRGQLEKETKSQSALA 1342
Cdd:TIGR02169  701 --ENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLE 778
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1343 HALQKAQRdcDLLREQYEEEQevkaelhRTLSKVNAEMVQWRmkyennviQRTEDLEDAKKELAIRLQEAAEAMGVANAR 1422
Cdd:TIGR02169  779 EALNDLEA--RLSHSRIPEIQ-------AELSKLEEEVSRIE--------ARLREIEQKLNRLTLEKEYLEKEIQELQEQ 841
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1423 NASLERARHQLQLELGDALSDLGKVRSAAARLDQKQLQSGKALADWKQKHEESQALLDASQKEVQALSTELLKLKNTYEE 1502
Cdd:TIGR02169  842 RIDLKEQIKSIEKEIENLNGKKEELEEELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSE 921
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1503 SIVGQETLRRENKnlqeEISNLTNQVREGTKNLTEMEKVKKLIEEEKTEVQvTLEETEGALERNESKILHFQLELLEAKA 1582
Cdd:TIGR02169  922 LKAKLEALEEELS----EIEDPKGEDEEIPEEELSLEDVQAELQRVEEEIR-ALEPVNMLAIQEYEEVLKRLDELKEKRA 996
                          810
                   ....*....|....*....
gi 767926067  1583 ELERKLSEKDEEIENFRRK 1601
Cdd:TIGR02169  997 KLEEERKAILERIEEYEKK 1015
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
853-1417 8.08e-18

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 90.38  E-value: 8.08e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  853 KSSEVGEEVAGLKEECAQLQKALEKSEFQREELKAKQVSLTQEKNDLILQLQAEQETLANVEEQCEWLIKSKIQLEARVK 932
Cdd:COG1196   240 ELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLE 319
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  933 ELSERVEEEEEINSELTARGRKLEDECFELKKEIDDLETMLVKSEKEKRTTEHKVKNLTEEVEFLNEDISKLNRAAKVVQ 1012
Cdd:COG1196   320 ELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELA 399
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1013 EAHQQTLDDLHMEEEKLSSLSKANLKLEQQVDELEGALEQERKARMNCERELHKLEGNLKLNRESMENLESSQRHLAEEL 1092
Cdd:COG1196   400 AQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAAL 479
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1093 RKKELELSQMNSKVENEKGLVAQLQktvkELQTQIKDLKEKLEAERTTRAkMERERADLTQDLADLNERLEEVGGSSLAQ 1172
Cdd:COG1196   480 AELLEELAEAAARLLLLLEAEADYE----GFLEGVKAALLLAGLRGLAGA-VAVLIGVEAAYEAALEAALAAALQNIVVE 554
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1173 LEITKKQETKFQKLHRDmEEATLHFETTSASLKKRHADSLAELEGQVENLQQVKQKLEKDKSDLQLEVDDLLTRVeqmTR 1252
Cdd:COG1196   555 DDEVAAAAIEYLKAAKA-GRATFLPLDKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLV---AA 630
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1253 AKANAEKLCTLYEERLHEATAKLDKVTQLANDLAAQKTKlwsESGEFLRRLEEKEALINQLSREKSNFTRQIEDLRGQLE 1332
Cdd:COG1196   631 RLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRE---LLAALLEAEAELEELAERLAEEELELEEALLAEEEEER 707
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1333 KETKSQSALAHALQKAQRDCDLLREQYEEEQEVKAELHRTLSKVNAEmvqwrmkyennVIQRTEDLEDAKKELAiRLQEA 1412
Cdd:COG1196   708 ELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALE-----------ELPEPPDLEELERELE-RLERE 775

                  ....*
gi 767926067 1413 AEAMG 1417
Cdd:COG1196   776 IEALG 780
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
1207-1832 1.03e-17

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 90.00  E-value: 1.03e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1207 RHADSLAELEGQVENLQ-QVKQ-------KLEKDKSDLQL---EVDDLLTRVEQMTRAKANAEKLCTLYEERLHEATAKL 1275
Cdd:COG1196   190 RLEDILGELERQLEPLErQAEKaeryrelKEELKELEAELlllKLRELEAELEELEAELEELEAELEELEAELAELEAEL 269
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1276 DKVTQLANDLAAQKTKLWSESGEFLRRLEEKEALINQLSREKSNFTRQIEDLRGQLEKETKSQSALAHALQKAQRDCDLL 1355
Cdd:COG1196   270 EELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEA 349
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1356 REQYEEEQEVKAELHRTLSKVNAEMVQWrmkyennviqrtedlEDAKKELAIRLQEAAEAMGVANARNASLERARHQLQL 1435
Cdd:COG1196   350 EEELEEAEAELAEAEEALLEAEAELAEA---------------EEELEELAEELLEALRAAAELAAQLEELEEAEEALLE 414
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1436 ELGDALSDLGKVRSAAARLDQKQLQSGKALADWKQKHEESQALLDASQKEVQALSTELLKLKNTYEEsIVGQETLRRENK 1515
Cdd:COG1196   415 RLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAE-LLEELAEAAARL 493
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1516 NLQEEISNLTNQVREGTKNLTEMEKVKKLIEEEKTEVQVTLEETEGALERNESKILHFQLELLEAKAELERKLSEKDEEI 1595
Cdd:COG1196   494 LLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEYLKAAKAGR 573
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1596 ENFrrkqqctidslqssldsEAKSRIEVTRLKKKMEEDLNEMELQLSCANRQVSEAtkslGQLQIQIKDLQMQLDDSTQL 1675
Cdd:COG1196   574 ATF-----------------LPLDKIRARAALAAALARGAIGAAVDLVASDLREAD----ARYYVLGDTLLGRTLVAARL 632
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1676 NSDLKEQVAVAERRNSLLQsELEDLRSLQEQTERGRRLSEEELLEATERInlfytqntsllSQKKKLEADVARMQKEAEE 1755
Cdd:COG1196   633 EAALRRAVTLAGRLREVTL-EGEGGSAGGSLTGGSRRELLAALLEAEAEL-----------EELAERLAEEELELEEALL 700
                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767926067 1756 VVQECQNAEEKAKKAAIEAANLSEELKKKQDTIAHLERTRENMEQTITDLQKRLAEAEQMALMGSRKQIQKLESRVR 1832
Cdd:COG1196   701 AEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELERLEREIE 777
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
856-1466 1.37e-17

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 89.73  E-value: 1.37e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   856 EVGEEVAGLKEECAQLQKALEKSEFQREELKAKQVSLTQEKNDLILQLQAEQETLANVEEQCEwlikskiQLEARVKELS 935
Cdd:TIGR02168  292 ALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELE-------SLEAELEELE 364
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   936 ERVEEEEEINSELTARGRKLEDECFELKKEIDDLETMLVKSEKEKRTTEHKVKNLTEEVEFLNEDISKLNRaakvvqEAH 1015
Cdd:TIGR02168  365 AELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAEL------KEL 438
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1016 QQTLDDLHMEEEKLSslsKANLKLEQQVDELEGALEQERKARMNCERELHKLEGNLKLNRESMENLESSQRHLAEELRKK 1095
Cdd:TIGR02168  439 QAELEELEEELEELQ---EELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNQ 515
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1096 E-------LELSQMNSKVENEKGLVAQLQKT-----VKELQTQIKD---LKE-----------------KLEAERTTRAK 1143
Cdd:TIGR02168  516 SglsgilgVLSELISVDEGYEAAIEAALGGRlqavvVENLNAAKKAiafLKQnelgrvtflpldsikgtEIQGNDREILK 595
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1144 MERERADLTQDLADLNERLEEVGGSSLAQLEITKKQETKFQKLHRDMEEATL-----------------HFETTSASLKK 1206
Cdd:TIGR02168  596 NIEGFLGVAKDLVKFDPKLRKALSYLLGGVLVVDDLDNALELAKKLRPGYRIvtldgdlvrpggvitggSAKTNSSILER 675
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1207 R-----HADSLAELEGQVENLQQVKQKLEKDKSDLQLEVDDLLTRVEQMTRAKANAEKLC-------------------- 1261
Cdd:TIGR02168  676 RreieeLEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLarleaeveqleeriaqlske 755
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1262 --------TLYEERLHEATAKLD-----------KVTQLANDLAAQKTKLWSESGEFLR---RLEEKEALINQLSREKSN 1319
Cdd:TIGR02168  756 lteleaeiEELEERLEEAEEELAeaeaeieeleaQIEQLKEELKALREALDELRAELTLlneEAANLRERLESLERRIAA 835
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1320 FTRQIEDLRGQLEKETKSQSALAHALQKAQRDCDLLREQYEEEQEVKAELHRTLSKVNAEMVQwRMKYENNVIQRTEDLE 1399
Cdd:TIGR02168  836 TERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELEE-LSEELRELESKRSELR 914
                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767926067  1400 DAKKELAIRLQEAAEAMGVANARNASL-ERARHQLQLELGDALSDLGKVRSAAARLDQKQLQSGKALA 1466
Cdd:TIGR02168  915 RELEELREKLAQLELRLEGLEVRIDNLqERLSEEYSLTLEEAEALENKIEDDEEEARRRLKRLENKIK 982
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
1142-1918 2.21e-17

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 88.97  E-value: 2.21e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1142 AKMERERADLTQDLADLNERLEEVG------GSSLAQLEITKKQETKFQKLHRDMEEATLhfeTTSASLKKRHADSLAEL 1215
Cdd:TIGR02169  166 AEFDRKKEKALEELEEVEENIERLDliidekRQQLERLRREREKAERYQALLKEKREYEG---YELLKEKEALERQKEAI 242
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1216 EGQVENLQQVKQKLEKDKSDLQLEVDDLLTRVEQMtrakanAEKLCTLYEERLHEATAKLDKVTqlandlaAQKTKLWSE 1295
Cdd:TIGR02169  243 ERQLASLEEELEKLTEEISELEKRLEEIEQLLEEL------NKKIKDLGEEEQLRVKEKIGELE-------AEIASLERS 309
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1296 SGEFLRRLEEKEALINQLSREKSNFTRQIEDLRGQLEKETKSQSALAHALQKAQRDCDLLREQYEEEQEVKAELHRTLSK 1375
Cdd:TIGR02169  310 IAEKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETRDELKD 389
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1376 VNAEMVQwrMKYENNVIQRTED-LEDAKKELAIRLQEAAEAMGVANARNASLERARHQLQLELgdalsdlgkvrsaaARL 1454
Cdd:TIGR02169  390 YREKLEK--LKREINELKRELDrLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEI--------------KKQ 453
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1455 DQKQLQSGKALADWKQKHEESQALLDASQKEVQALSTELLKLKNTYEESIVGQETLRRENKNLQEEISNLTNQVREGTKn 1534
Cdd:TIGR02169  454 EWKLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQRELAEAEAQARASEERVRGGRAVEEVLKASIQGVHGTVAQLGS- 532
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1535 lTEMEKVKKLIEEEKTEVQVTLEETEG--------ALERNESKILHFQLELLEAKAELERKLSEK------------DEE 1594
Cdd:TIGR02169  533 -VGERYATAIEVAAGNRLNNVVVEDDAvakeaielLKRRKAGRATFLPLNKMRDERRDLSILSEDgvigfavdlvefDPK 611
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1595 IEN-FRRKQQCTI--DSLQS-----------SLDSE--------------AKSRIEVTRLKK----KMEEDLNEMELQLS 1642
Cdd:TIGR02169  612 YEPaFKYVFGDTLvvEDIEAarrlmgkyrmvTLEGElfeksgamtggsraPRGGILFSRSEPaelqRLRERLEGLKRELS 691
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1643 CANRQVSEATKSLGQLQIQIKDLQMQLddstqlnSDLKEQVAVAERRNSLLQSELEDLRSLQEQTERGRRLSEEELLEAT 1722
Cdd:TIGR02169  692 SLQSELRRIENRLDELSQELSDASRKI-------GEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELE 764
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1723 ERINLFYTQNTSLLSQKKKLEADVArmQKEAEEVVQECQNAEEKAKKAAIEAANLSEELKKKQDTIAHLERTRENMEQTI 1802
Cdd:TIGR02169  765 ARIEELEEDLHKLEEALNDLEARLS--HSRIPEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQR 842
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1803 TDLQKRLAEAEQmALMGSRKQIQKLESRVrelegelegeirrsAEAQRGARRLERCIKELtyqaeedKKNLSRMQTQMDK 1882
Cdd:TIGR02169  843 IDLKEQIKSIEK-EIENLNGKKEELEEEL--------------EELEAALRDLESRLGDL-------KKERDELEAQLRE 900
                          810       820       830
                   ....*....|....*....|....*....|....*.
gi 767926067  1883 LQLKVQNYKQQVEVAETQANQYLSKYKKQQHELNEV 1918
Cdd:TIGR02169  901 LERKIEELEAQIEKKRKRLSELKAKLEALEEELSEI 936
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
1306-1945 4.26e-17

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 88.19  E-value: 4.26e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1306 KEALiNQLSREKSNFTRqIEDLRGQLEKETKSQSALAHALQKAQRdcdlLREQYEEEQ---------EVKAELHRTLSKV 1376
Cdd:TIGR02168  175 KETE-RKLERTRENLDR-LEDILNELERQLKSLERQAEKAERYKE----LKAELRELElallvlrleELREELEELQEEL 248
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1377 NaEMVQWRMKYENNVIQRTEDLEDAKKELAIRLQEAAEAMGVANARNASLERARHQLQL---ELGDALSDLGKVRSAAAR 1453
Cdd:TIGR02168  249 K-EAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQIlreRLANLERQLEELEAQLEE 327
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1454 LDQKQLQSGKALADWKQKHEESQALLDASQKEVQALSTELLKLKNTYEESIVGQETLRRENKNLQEEISNLTNQVREGTK 1533
Cdd:TIGR02168  328 LESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEA 407
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1534 NLTEMEK------------VKKLIEEEKTEVQVTLEETEGALERNESKILHFQLELLEAKAELERKLSEKDEEIENFRRK 1601
Cdd:TIGR02168  408 RLERLEDrrerlqqeieelLKKLEEAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQL 487
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1602 QQcTIDSLQS---------------------------------SLDSEAKSRIEV------------------------- 1623
Cdd:TIGR02168  488 QA-RLDSLERlqenlegfsegvkallknqsglsgilgvlseliSVDEGYEAAIEAalggrlqavvvenlnaakkaiaflk 566
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1624 -----------------TRLKKKMEEDLNEMELQLSCANRQVSEATKS-------LGQLQIqIKDLQMQLDDSTQLNSDL 1679
Cdd:TIGR02168  567 qnelgrvtflpldsikgTEIQGNDREILKNIEGFLGVAKDLVKFDPKLrkalsylLGGVLV-VDDLDNALELAKKLRPGY 645
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1680 K------EQV--------AVAERRNSLL--QSELEDLRSLQEQTERGRRLSEEELLEATERINLFYTQNTSLLSQKKKLE 1743
Cdd:TIGR02168  646 RivtldgDLVrpggvitgGSAKTNSSILerRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELS 725
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1744 ADVARMQKEAEEVVQECQNAEEKAKKAAIEAANL-------SEELKKKQDTIAHLERTRENMEQTITDLQKRLAEAEQmA 1816
Cdd:TIGR02168  726 RQISALRKDLARLEAEVEQLEERIAQLSKELTELeaeieelEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALRE-A 804
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1817 LMGSRKQIQKLESRVRELEGELEGEIRRSAEAQRGARRLERCIKELTYQAEEDKKNLSRMQTQMDKLQLKVQNYKQQVEV 1896
Cdd:TIGR02168  805 LDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERAS 884
                          730       740       750       760
                   ....*....|....*....|....*....|....*....|....*....
gi 767926067  1897 AETQANQYLSKYKKQQHELNEVKERAEVAESQVNKLKIKAREFGKKVQE 1945
Cdd:TIGR02168  885 LEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEG 933
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
1212-1945 6.42e-17

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 87.43  E-value: 6.42e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1212 LAELEGQVENLQQVKQKLEKDKsDLQLEVDD-----LLTRVEQMTRAKANAEKlctlyeeRLHEATAKLDKVTQLANDLA 1286
Cdd:TIGR02169  193 IDEKRQQLERLRREREKAERYQ-ALLKEKREyegyeLLKEKEALERQKEAIER-------QLASLEEELEKLTEEISELE 264
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1287 AqktklwsESGEFLRRLEEKEALINQLSREKSN-FTRQIEDLRGQLEKETKSQSALAHALQKAQRDCDLLREQYEEEQEV 1365
Cdd:TIGR02169  265 K-------RLEEIEQLLEELNKKIKDLGEEEQLrVKEKIGELEAEIASLERSIAEKERELEDAEERLAKLEAEIDKLLAE 337
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1366 KAELHRTLSKVNAEMVQWrmkyennvIQRTEDLEDAKKELAIRLQEAAEAMGVANARNASLERARHQLQLELGDALSDLG 1445
Cdd:TIGR02169  338 IEELEREIEEERKRRDKL--------TEEYAELKEELEDLRAELEEVDKEFAETRDELKDYREKLEKLKREINELKRELD 409
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1446 KVRSAAARLDQKQLQSGKALADWKQKHEESQALLDASQKEVQALSTELlklkntyEESIVGQETLRRENKNLQEEISNLT 1525
Cdd:TIGR02169  410 RLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQEWKL-------EQLAADLSKYEQELYDLKEEYDRVE 482
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1526 NQVREGTKNLTEMEKVKKLIEEEKTEVQVTLEEtegaLERNESKILHFQLELLEAKAELERKLsekdeEIENFRRKQQCT 1605
Cdd:TIGR02169  483 KELSKLQRELAEAEAQARASEERVRGGRAVEEV----LKASIQGVHGTVAQLGSVGERYATAI-----EVAAGNRLNNVV 553
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1606 IDSlqsslDSEAKSRIEVTRLKK----------KMEE------------------DLNEMELQLSCANRQVSEATKSLGQ 1657
Cdd:TIGR02169  554 VED-----DAVAKEAIELLKRRKagratflplnKMRDerrdlsilsedgvigfavDLVEFDPKYEPAFKYVFGDTLVVED 628
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1658 LQIQiKDLQMQLDDSTqLNSDLKEQV------AVAERRNSLLQ-SELEDLRSLQEQTERGRRLSEEELLEATERINLFYt 1730
Cdd:TIGR02169  629 IEAA-RRLMGKYRMVT-LEGELFEKSgamtggSRAPRGGILFSrSEPAELQRLRERLEGLKRELSSLQSELRRIENRLD- 705
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1731 qntSLLSQKKKLEADVARMQKEAEEVVQECQNAEEKAKKAAIEAANLSEELKKKQDTIAHLERTRENMEQTITDLQKRLA 1810
Cdd:TIGR02169  706 ---ELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEEALN 782
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1811 EAEQMALMGSRKQIQKLESRVRelegelegEIRRSAEAQrgARRLERCIKELTYQAEEDKKNLSRMQTQMDKLQLKVQNY 1890
Cdd:TIGR02169  783 DLEARLSHSRIPEIQAELSKLE--------EEVSRIEAR--LREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSI 852
                          730       740       750       760       770
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 767926067  1891 KQQVEVAETQANQYLSKYKKQQHELNEVKERAEVAESQVNKLKIKAREFGKKVQE 1945
Cdd:TIGR02169  853 EKEIENLNGKKEELEEELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEE 907
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
1135-1759 8.04e-17

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 87.30  E-value: 8.04e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1135 EAERttraKMERERADLTQdladLNERLEEVGgSSLAQLEITKKQETKFQKL-----HRDMEEATLHFETTSASLKK--- 1206
Cdd:COG1196   176 EAER----KLEATEENLER----LEDILGELE-RQLEPLERQAEKAERYRELkeelkELEAELLLLKLRELEAELEElea 246
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1207 ---RHADSLAELEGQVENLQQVKQKLEKDKSDLQLEVDDLLTRVEQMTRAKANAEKLCTLYEERLHEATAKLDKVTQLAN 1283
Cdd:COG1196   247 eleELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELA 326
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1284 DLAAQKTKLWSESGEFLRRLEEKEALINQLSREKSNFTRQIEDLRGQLEKETKSQSALAHALQKAQRDCDLLREQYEEEQ 1363
Cdd:COG1196   327 ELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELE 406
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1364 EVKAELHRTLSKVNAEMVQWRMKyENNVIQRTEDLEDAKKELAIRLQEAAEAMGVANARNASLERARHQLQLELGDALSD 1443
Cdd:COG1196   407 EAEEALLERLERLEEELEELEEA-LAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEE 485
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1444 LGKVRSAAARLDQKQLQSGKALADWKQKHEESQ------------------------ALLDASQKEVQALSTELLKLKNT 1499
Cdd:COG1196   486 LAEAAARLLLLLEAEADYEGFLEGVKAALLLAGlrglagavavligveaayeaaleaALAAALQNIVVEDDEVAAAAIEY 565
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1500 YEESIVGQETLRRENK-NLQEEISNLTNQVREGTKNLTEMEKVKKLIEEEKTEVQVTLEETEGALERNESKILHFQLELL 1578
Cdd:COG1196   566 LKAAKAGRATFLPLDKiRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGR 645
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1579 EAKAELERKLSEKDEEIENFRRKQQctidslQSSLDSEAKSRIEVTRLKKKMEEDLNEMELQLSCANRQVSEATKSLGQL 1658
Cdd:COG1196   646 LREVTLEGEGGSAGGSLTGGSRREL------LAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEE 719
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1659 QIQIKDLQMQLDDSTQLNSDLKEQVAVAERRNSLLQ-SELEDLRSLQEQTERGRR----------LSEEELLEATERINL 1727
Cdd:COG1196   720 ELEEEALEEQLEAEREELLEELLEEEELLEEEALEElPEPPDLEELERELERLEReiealgpvnlLAIEEYEELEERYDF 799
                         650       660       670
                  ....*....|....*....|....*....|..
gi 767926067 1728 FYTQNTSLLSQKKKLEADVARMQKEAEEVVQE 1759
Cdd:COG1196   800 LSEQREDLEEARETLEEAIEEIDRETRERFLE 831
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
1074-1724 3.63e-16

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 84.77  E-value: 3.63e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1074 NRESMENLESSQRHLAEELRK----KELELSQMNSKVENEKGLVAQLQKTVKELQTQIKDLKEKLEAERTTRAKMERERa 1149
Cdd:pfam05483   72 NSEGLSRLYSKLYKEAEKIKKwkvsIEAELKQKENKLQENRKIIEAQRKAIQELQFENEKVSLKLEEEIQENKDLIKEN- 150
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1150 DLTQDLADLNERLEEVGGSSLAQLEITKKQETK-FQKLHRDMEEATLHFETTSASLKKRHADSLAELEGQVENLQQVKQK 1228
Cdd:pfam05483  151 NATRHLCNLLKETCARSAEKTKKYEYEREETRQvYMDLNNNIEKMILAFEELRVQAENARLEMHFKLKEDHEKIQHLEEE 230
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1229 LEKDKSDLQLEVDDLLTrveQMTRAKANAEKLCTLYEErlheataKLDKVTQLandlaAQKTKLWSESgeflrrleekea 1308
Cdd:pfam05483  231 YKKEINDKEKQVSLLLI---QITEKENKMKDLTFLLEE-------SRDKANQL-----EEKTKLQDEN------------ 283
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1309 lINQLSREKSNFTRQIEDLRGQLEKETKSQSALAHALQKAQRDCDLLREQYEEEQEVKAELHRTLSKVNAEMVQWRMKYE 1388
Cdd:pfam05483  284 -LKELIEKKDHLTKELEDIKMSLQRSMSTQKALEEDLQIATKTICQLTEEKEAQMEELNKAKAAHSFVVTEFEATTCSLE 362
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1389 N---NVIQRTEDLEDAKKELAIRLQEAAEAMgvanarnASLERARHQLQLElgdaLSDLGKVRSAAARLDQKQLQSGKAL 1465
Cdd:pfam05483  363 EllrTEQQRLEKNEDQLKIITMELQKKSSEL-------EEMTKFKNNKEVE----LEELKKILAEDEKLLDEKKQFEKIA 431
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1466 ADWKQKHEESQALLDASQKEVQALSTELLKLKNTyeesivgQETLRRENKNLQEEISNLTNQVREGTKNLTEMEKVKKLI 1545
Cdd:pfam05483  432 EELKGKEQELIFLLQAREKEIHDLEIQLTAIKTS-------EEHYLKEVEDLKTELEKEKLKNIELTAHCDKLLLENKEL 504
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1546 EEEKTEVQVTLEETEGALERNESKilhfQLELLEAKAELERKLSEKDEEIENFRRKQQCTIDSLQSSLDSEAKSRIEVTR 1625
Cdd:pfam05483  505 TQEASDMTLELKKHQEDIINCKKQ----EERMLKQIENLEEKEMNLRDELESVREEFIQKGDEVKCKLDKSEENARSIEY 580
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1626 LKKKMEEDLNEMELQLSCANRQVSEATKSLGQLQIQIKDLQMQ-LDDSTQLNSdLKEQVAVAERRNSLLQSELEDLRSLQ 1704
Cdd:pfam05483  581 EVLKKEKQMKILENKCNNLKKQIENKNKNIEELHQENKALKKKgSAENKQLNA-YEIKVNKLELELASAKQKFEEIIDNY 659
                          650       660
                   ....*....|....*....|
gi 767926067  1705 EQTERGRRLSEEELLEATER 1724
Cdd:pfam05483  660 QKEIEDKKISEEKLLEEVEK 679
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
1306-1938 1.47e-15

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 83.06  E-value: 1.47e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1306 KEALiNQLSREKSNFTRqIEDLRGQLEK----------------------ETKSQSALAHALQKAQRDCDLLREQYEEEQ 1363
Cdd:COG1196   175 EEAE-RKLEATEENLER-LEDILGELERqleplerqaekaeryrelkeelKELEAELLLLKLRELEAELEELEAELEELE 252
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1364 EVKAELHRTLSKVNAEMvqwrmkyennviqrtEDLEDAKKELAIRLQEAAEAMGVANARNASLERARHQLQLELGDALSD 1443
Cdd:COG1196   253 AELEELEAELAELEAEL---------------EELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEER 317
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1444 LGKVRSAAARLDQKQLQSGKALADWKQKHEESQALLDASQKEVQALSTELLKLKNTYEESIVGQETLRRENKNLQEEISN 1523
Cdd:COG1196   318 LEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAE 397
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1524 LTNQVREGTKNLTEMEKVKKLIEEEKTEVQVTLEETEGALERNESKILHFQLELLEAKAELERKLSEKDEEIENFRRKQQ 1603
Cdd:COG1196   398 LAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEA 477
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1604 CTIDSLQSSLDSEAKsrievtrlkkkmEEDLNEMELQLSCANRQVSEATKSLGQLQIQIKDLQMQLDDSTQLNSDLKEQV 1683
Cdd:COG1196   478 ALAELLEELAEAAAR------------LLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALA 545
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1684 AVAERRNSLLQSELEDLRSLQEQTERGR----RLSEEELLEATERINLFYTQNTSLLSQKKKLEADVARMQKEAEEVVQE 1759
Cdd:COG1196   546 AALQNIVVEDDEVAAAAIEYLKAAKAGRatflPLDKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGR 625
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1760 CQNAEEKAKKAAIEAANLSEELKKKQDTIAHLERTRENMEQTITDLQKRLAEAEQMALmgSRKQIQKLESRVRELEGELE 1839
Cdd:COG1196   626 TLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEE--LAERLAEEELELEEALLAEE 703
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1840 GEIRRSAEAQRGARRLERCIKELTYQAEEDKKNLSRMQTQMDKLQLKVQNYKQQVEVAETQANQYLSKYKKQ-------- 1911
Cdd:COG1196   704 EEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELERLEREiealgpvn 783
                         650       660       670
                  ....*....|....*....|....*....|
gi 767926067 1912 ---QHELNEVKERAEVAESQVNKLKiKARE 1938
Cdd:COG1196   784 llaIEEYEELEERYDFLSEQREDLE-EARE 812
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
1473-1946 2.44e-15

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 82.53  E-value: 2.44e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1473 EESQALLDASQKEVQALSTELLKLKNTYEESIVGqetLRRENKNLQEEISNLTNQV--REGTKNLTEMEKVKKLIEEEKT 1550
Cdd:pfam01576   60 EEMRARLAARKQELEEILHELESRLEEEEERSQQ---LQNEKKKMQQHIQDLEEQLdeEEAARQKLQLEKVTTEAKIKKL 136
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1551 EVQVTLEETEGALERNESKILHfqlellEAKAELERKLSEKDEEIENF---RRKQQCTIDSLQSSLDSEAKSRIEVTRLK 1627
Cdd:pfam01576  137 EEDILLLEDQNSKLSKERKLLE------ERISEFTSNLAEEEEKAKSLsklKNKHEAMISDLEERLKKEEKGRQELEKAK 210
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1628 KKMEEDLNEMELQLSCANRQVSEATKSLGQLQIQIKDLQMQLDDSTQLNSDLKEQVAVAERRNSLLQSELEDLRSLQEQT 1707
Cdd:pfam01576  211 RKLEGESTDLQEQIAELQAQIAELRAQLAKKEEELQAALARLEEETAQKNNALKKIRELEAQISELQEDLESERAARNKA 290
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1708 ERGRRLSEEELlEATeRINLFYTQNTSLLSQ--KKKLEADVARMQK--EAEEVVQECQnAEEKAKKAAIEAANLSEELKK 1783
Cdd:pfam01576  291 EKQRRDLGEEL-EAL-KTELEDTLDTTAAQQelRSKREQEVTELKKalEEETRSHEAQ-LQEMRQKHTQALEELTEQLEQ 367
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1784 KQDTIAHLERTRENMEQTITDLQKRLAEAEQMALMGSRKQiQKLESRVRELEGELEGEIRRSAEAQRGARRLERCIKELT 1863
Cdd:pfam01576  368 AKRNKANLEKAKQALESENAELQAELRTLQQAKQDSEHKR-KKLEGQLQELQARLSESERQRAELAEKLSKLQSELESVS 446
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1864 YQAEEDKKNLSRMQTQMDKLQLKVQNYKQQVEvAETQANQYLSKYKKQ--------QHELNEVKERAEVAESQVNKLKIK 1935
Cdd:pfam01576  447 SLLNEAEGKNIKLSKDVSSLESQLQDTQELLQ-EETRQKLNLSTRLRQledernslQEQLEEEEEAKRNVERQLSTLQAQ 525
                          490
                   ....*....|.
gi 767926067  1936 AREFGKKVQEE 1946
Cdd:pfam01576  526 LSDMKKKLEED 536
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
858-1762 5.19e-15

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 81.25  E-value: 5.19e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   858 GEEVAGLKEECAQLQKALEKSEFQREELKAKQVSLTQEKnDLILQLQAEQETLANVEEQCEWLIKSKIQLEARVKELSER 937
Cdd:TIGR00606  199 GQKVQEHQMELKYLKQYKEKACEIRDQITSKEAQLESSR-EIVKSYENELDPLKNRLKEIEHNLSKIMKLDNEIKALKSR 277
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   938 VEEEEEINSELTargRKLEDECFELKKEIDDLETMlvkSEKEKRTTEHKVKNLTEEVEFLNEDISKLN--RAAKVVQEAH 1015
Cdd:TIGR00606  278 KKQMEKDNSELE---LKMEKVFQGTDEQLNDLYHN---HQRTVREKERELVDCQRELEKLNKERRLLNqeKTELLVEQGR 351
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1016 QQTLDDLHMEEEKLSSLSKANLKLEQQVDELEGALEQERKARMNCERELHKLEGNLKLNRESMENLESSQRHLAEELRKK 1095
Cdd:TIGR00606  352 LQLQADRHQEHIRARDSLIQSLATRLELDGFERGPFSERQIKNFHTLVIERQEDEAKTAAQLCADLQSKERLKQEQADEI 431
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1096 ELELSQMNSKVENEKglvAQLQKTVKELQTQIKDLKeklEAERTTRAKMERERAdLTQDLADLNERLEEvggsslAQLEI 1175
Cdd:TIGR00606  432 RDEKKGLGRTIELKK---EILEKKQEELKFVIKELQ---QLEGSSDRILELDQE-LRKAERELSKAEKN------SLTET 498
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1176 TKKQETKFQKLHRDMEEaTLHFETTSASLKKRHADSLAELEGQVENLQQVKQKLEKDKSDLQLEVDDLL---TRVEQMTR 1252
Cdd:TIGR00606  499 LKKEVKSLQNEKADLDR-KLRKLDQEMEQLNHHTTTRTQMEMLTKDKMDKDEQIRKIKSRHSDELTSLLgyfPNKKQLED 577
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1253 AKANAEKLCTLYEERLHEATAKLDKVTQLANDLAAQKTKLWSEsgefLRRLEEKeaLINQLSREksNFTRQIEDLRGQLE 1332
Cdd:TIGR00606  578 WLHSKSKEINQTRDRLAKLNKELASLEQNKNHINNELESKEEQ----LSSYEDK--LFDVCGSQ--DEESDLERLKEEIE 649
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1333 KETKSQSALAHALQKAqrdcDLLREQYEEEQEVKAELHRTLSKVNAEMVQWRMKYENNVIQRTEDLEDAKKELAIRLQEA 1412
Cdd:TIGR00606  650 KSSKQRAMLAGATAVY----SQFITQLTDENQSCCPVCQRVFQTEAELQEFISDLQSKLRLAPDKLKSTESELKKKEKRR 725
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1413 AEAMGVANARNASLERarhqLQLELGDALSDLGKVRSAAARLdQKQLQSGKALADWKQKHEESQALLDASQKEVQALSTE 1492
Cdd:TIGR00606  726 DEMLGLAPGRQSIIDL----KEKEIPELRNKLQKVNRDIQRL-KNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQME 800
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1493 LLKLKNTYEE------SIVGQETLRRENKNLQEEISNLTNQVREGTKNLTEMEKVKKLIEEEKTEVQvTLEETEGALERN 1566
Cdd:TIGR00606  801 LKDVERKIAQqaaklqGSDLDRTVQQVNQEKQEKQHELDTVVSKIELNRKLIQDQQEQIQHLKSKTN-ELKSEKLQIGTN 879
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1567 ESKILHFQLELLEAKAELE---RKLSEKDEEI---ENFRRKQQCTIDSLQSSLDSEAK-SRIEVTRLKKKM--------- 1630
Cdd:TIGR00606  880 LQRRQQFEEQLVELSTEVQsliREIKDAKEQDsplETFLEKDQQEKEELISSKETSNKkAQDKVNDIKEKVknihgymkd 959
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1631 ---------EEDLNEMELQLSCANRQVSEATKSLGQLQIQIKDLQMQLDDSTQLNSDLKEQVAVAERRNSLLQSELEDLR 1701
Cdd:TIGR00606  960 ienkiqdgkDDYLKQKETELNTVNAQLEECEKHQEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRENELKEVEEELKQ 1039
                          890       900       910       920       930       940
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767926067  1702 SLQEQTERGRRLSEEELLEATERINLFYTQNTSLLSQKKKLEADVARMQKEAEEvvQECQN 1762
Cdd:TIGR00606 1040 HLKEMGQMQVLQMKQEHQKLEENIDLIKRNHVLALGRQKGYEKEIKHFKKELRE--PQFRD 1098
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
864-1560 7.00e-15

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 80.93  E-value: 7.00e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   864 LKEECAQLQKALEKSEFQREELKAKQVSLTQEKNDLILQLQAEQETLANVEEQCEWLIK-SKIQLEARVKELSERVEEEE 942
Cdd:pfam15921  108 LRQSVIDLQTKLQEMQMERDAMADIRRRESQSQEDLRNQLQNTVHELEAAKCLKEDMLEdSNTQIEQLRKMMLSHEGVLQ 187
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   943 EINSELT----ARGRKLEDEcfelkkeiDDLETMLVKSEKEkrTTEHKVKNLTEEVEFLNEDISKLNRAAKVVQEAHQQT 1018
Cdd:pfam15921  188 EIRSILVdfeeASGKKIYEH--------DSMSTMHFRSLGS--AISKILRELDTEISYLKGRIFPVEDQLEALKSESQNK 257
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1019 LDDLhmeeeklssLSKANLKLEQQVDELE----GALEQERKARmnceRELHKLEGNLKLNRESMENLESS-QRHLAEelr 1093
Cdd:pfam15921  258 IELL---------LQQHQDRIEQLISEHEveitGLTEKASSAR----SQANSIQSQLEIIQEQARNQNSMyMRQLSD--- 321
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1094 kKELELSQMNSKVENEKGLvaqLQKTVKELQTQIKDLKEKLEAERTTRAKMERERADLTQDL----ADLNERLEEvggss 1169
Cdd:pfam15921  322 -LESTVSQLRSELREAKRM---YEDKIEELEKQLVLANSELTEARTERDQFSQESGNLDDQLqkllADLHKREKE----- 392
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1170 laqLEITKKQETKF-----------QKLHRDMEEATLHFETTSASLKKRHADSLAELEGQVENLQQVKQKLEKDKS-DLQ 1237
Cdd:pfam15921  393 ---LSLEKEQNKRLwdrdtgnsitiDHLRRELDDRNMEVQRLEALLKAMKSECQGQMERQMAAIQGKNESLEKVSSlTAQ 469
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1238 LEVDDLLTR--VEQMTRAKANAEK-------LCTLYEERLHEATAKLDKVTQLAN--DLAAQKTKLWSESGEFLRRLE-E 1305
Cdd:pfam15921  470 LESTKEMLRkvVEELTAKKMTLESsertvsdLTASLQEKERAIEATNAEITKLRSrvDLKLQELQHLKNEGDHLRNVQtE 549
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1306 KEALINQLSREKsnftRQIEDLRGQLEKETK-----SQSALAHALQKAQRDCDLlREQYEEEQEVKA----------ELH 1370
Cdd:pfam15921  550 CEALKLQMAEKD----KVIEILRQQIENMTQlvgqhGRTAGAMQVEKAQLEKEI-NDRRLELQEFKIlkdkkdakirELE 624
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1371 RTLSKVNAEMVQW------RMKYENNVIQRTEDLEDAKKELAIRLQEAAEAMGV--ANARNAS--LERARHQLQLELGDA 1440
Cdd:pfam15921  625 ARVSDLELEKVKLvnagseRLRAVKDIKQERDQLLNEVKTSRNELNSLSEDYEVlkRNFRNKSeeMETTTNKLKMQLKSA 704
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1441 LSDLGKVRSAAARLD-------------QKQLQSGKALADWKQKHEE--SQALLDASQK------EVQALSTELLKLKnT 1499
Cdd:pfam15921  705 QSELEQTRNTLKSMEgsdghamkvamgmQKQITAKRGQIDALQSKIQflEEAMTNANKEkhflkeEKNKLSQELSTVA-T 783
                          730       740       750       760       770       780
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767926067  1500 YEESIVGQ-ETLRRENKNLQEEISNLTNQVREGTKNLTEMEKVKKLIEEE--KTEVQVTLEETE 1560
Cdd:pfam15921  784 EKNKMAGElEVLRSQERRLKEKVANMEVALDKASLQFAECQDIIQRQEQEsvRLKLQHTLDVKE 847
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
1001-1945 1.60e-14

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 79.71  E-value: 1.60e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1001 ISKLNRAAKVVQEaHQQTLDDLHMEEEKLSSLSKANLKLEQQVDELEGALEQERKARMNCERELHKLEGNLKlnreSMEN 1080
Cdd:TIGR00606  185 IKALETLRQVRQT-QGQKVQEHQMELKYLKQYKEKACEIRDQITSKEAQLESSREIVKSYENELDPLKNRLK----EIEH 259
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1081 LESSQRHLAEELR---KKELELSQMNSKVEnekglvaqlQKTVKELQTQIKDLKEKLEAERTTRAKMERERADLTQDLAD 1157
Cdd:TIGR00606  260 NLSKIMKLDNEIKalkSRKKQMEKDNSELE---------LKMEKVFQGTDEQLNDLYHNHQRTVREKERELVDCQRELEK 330
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1158 LNERleevggsslAQLEITKKQETKFQKLHRDMEEATLHFETTSASLKKRHADSLAELEGqvenlqqvkqkLEKDkSDLQ 1237
Cdd:TIGR00606  331 LNKE---------RRLLNQEKTELLVEQGRLQLQADRHQEHIRARDSLIQSLATRLELDG-----------FERG-PFSE 389
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1238 LEVDDLLTRV-EQMTRAKANAEKLCTLYEERLHEATAKLDKvtqlandLAAQKTKLWSESGEFLRRLEEKEALINQLSRE 1316
Cdd:TIGR00606  390 RQIKNFHTLViERQEDEAKTAAQLCADLQSKERLKQEQADE-------IRDEKKGLGRTIELKKEILEKKQEELKFVIKE 462
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1317 KSNFTRQIEDLRGQLEKETKSQSALAHALQKAQRDCDLLREQYEeeQEVKAELHRTLSKVNAEMVQwrMKYENNVIQRTE 1396
Cdd:TIGR00606  463 LQQLEGSSDRILELDQELRKAERELSKAEKNSLTETLKKEVKSL--QNEKADLDRKLRKLDQEMEQ--LNHHTTTRTQME 538
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1397 DLEDAKKE-----LAIRLQEAAEAMGVAN--ARNASLERARHQLQLELGDALSDLGKVRSAAARLDQKQLQSGKALADWK 1469
Cdd:TIGR00606  539 MLTKDKMDkdeqiRKIKSRHSDELTSLLGyfPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASLEQNKNHINNELESKE 618
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1470 QKH-------------EESQALLDASQKEVQALSTELLKL--KNTYEESIVGQETLRREN------------KNLQEEIS 1522
Cdd:TIGR00606  619 EQLssyedklfdvcgsQDEESDLERLKEEIEKSSKQRAMLagATAVYSQFITQLTDENQSccpvcqrvfqteAELQEFIS 698
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1523 NLTNQVREGTKNLTEMEKVKKLIEEEKTEVQVTLEETEGALERNESKILhfqlELLEAKAELERKLSEKDEEIEnfrrKQ 1602
Cdd:TIGR00606  699 DLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLAPGRQSIIDLKEKEIP----ELRNKLQKVNRDIQRLKNDIE----EQ 770
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1603 QCTIDSLQSSLDSEAKSRIEVTRLKK-KMEEDLNEMELQLSCANRQVSEATKSLGQLQIQIKDLQMQLDDSTQLNSDLKE 1681
Cdd:TIGR00606  771 ETLLGTIMPEEESAKVCLTDVTIMERfQMELKDVERKIAQQAAKLQGSDLDRTVQQVNQEKQEKQHELDTVVSKIELNRK 850
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1682 QVAVAERRNSLLQSELEDLRS--LQEQTERGRRLS-EEELLEATERINLFYTQNTSLLSQKKKLEADVARMQKEAEEVVQ 1758
Cdd:TIGR00606  851 LIQDQQEQIQHLKSKTNELKSekLQIGTNLQRRQQfEEQLVELSTEVQSLIREIKDAKEQDSPLETFLEKDQQEKEELIS 930
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1759 ECQnaeekakkaaieaanlsEELKKKQDTIAHLERTRENMEQTITDLQKRLAEAEQMALMGSRKQIQKLESRVRELEgel 1838
Cdd:TIGR00606  931 SKE-----------------TSNKKAQDKVNDIKEKVKNIHGYMKDIENKIQDGKDDYLKQKETELNTVNAQLEECE--- 990
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1839 egeiRRSAEAQRGARRLERCIKELTYQAEEDKKNLSRMQTQMDKLQLKVQNYKQQVEVAETQANQYLSKYKKQQHELNEV 1918
Cdd:TIGR00606  991 ----KHQEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRENELKEVEEELKQHLKEMGQMQVLQMKQEHQKLEENIDLI 1066
                          970       980
                   ....*....|....*....|....*..
gi 767926067  1919 KERAEVAESQVNKLKIKAREFGKKVQE 1945
Cdd:TIGR00606 1067 KRNHVLALGRQKGYEKEIKHFKKELRE 1093
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
957-1456 2.54e-14

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 78.93  E-value: 2.54e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  957 DECFELKKEIDDLETMLVKSEKEKRTTEHKVKNLTEEVEFLNEDISKLnraakvvqeahqqtLDDLHMEEEKLSSLskan 1036
Cdd:PRK02224  251 EELETLEAEIEDLRETIAETEREREELAEEVRDLRERLEELEEERDDL--------------LAEAGLDDADAEAV---- 312
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1037 lklEQQVDELEGALEQERKARMNCERELHKLEGNLKLNRESMENLESSqrhlAEELRKKELELsqmNSKVENEKGLVAQL 1116
Cdd:PRK02224  313 ---EARREELEDRDEELRDRLEECRVAAQAHNEEAESLREDADDLEER----AEELREEAAEL---ESELEEAREAVEDR 382
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1117 QKTVKELQTQIKDLKEKLEAERTTRAKMERERADLTQDLADLNERLEEVggsslaqleitkkqETKFQKLHRDMEEATLH 1196
Cdd:PRK02224  383 REEIEELEEEIEELRERFGDAPVDLGNAEDFLEELREERDELREREAEL--------------EATLRTARERVEEAEAL 448
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1197 FE-----TTSASLKKR-HADSLAELEGQVEnlqqvkqKLEKDKSDLQLEVDDLLTRVEQMTRAKANAEKLCTLYE----- 1265
Cdd:PRK02224  449 LEagkcpECGQPVEGSpHVETIEEDRERVE-------ELEAELEDLEEEVEEVEERLERAEDLVEAEDRIERLEErredl 521
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1266 -ERLHEATAKLDKVTQLANDLAAQKTKLWSESGEFLRRLEEKEALINQLSREKSNFTRQIEDL---RGQLEKETKSQSAL 1341
Cdd:PRK02224  522 eELIAERRETIEEKRERAEELRERAAELEAEAEEKREAAAEAEEEAEEAREEVAELNSKLAELkerIESLERIRTLLAAI 601
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1342 AHALQKAQRdcdlLREQYEEEQEVKAELHRTLSKVNAEMVQWRMKYENNviqRTEDLEDAKKELAIRLQEAAEAMgvana 1421
Cdd:PRK02224  602 ADAEDEIER----LREKREALAELNDERRERLAEKRERKRELEAEFDEA---RIEEAREDKERAEEYLEQVEEKL----- 669
                         490       500       510
                  ....*....|....*....|....*....|....*
gi 767926067 1422 rnASLERARHQLQLELGDALSDLGKVRSAAARLDQ 1456
Cdd:PRK02224  670 --DELREERDDLQAEIGAVENELEELEELRERREA 702
PTZ00121 PTZ00121
MAEBL; Provisional
951-1810 3.10e-14

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 79.03  E-value: 3.10e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  951 RGRKLEDECFELKKEIDDLETMLVKSEKEKRTTEHKVKNLTEEVEFLNEDISKLNRAAKVVQEAHQQtlDDLHMEEEKLS 1030
Cdd:PTZ00121 1070 EGLKPSYKDFDFDAKEDNRADEATEEAFGKAEEAKKTETGKAEEARKAEEAKKKAEDARKAEEARKA--EDARKAEEARK 1147
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1031 SLSKANLKLEQQVDELEGAlEQERKARmncerELHKLEGNlklnRESMENLESSQRHLAEELRKKELElsqmnSKVENEK 1110
Cdd:PTZ00121 1148 AEDAKRVEIARKAEDARKA-EEARKAE-----DAKKAEAA----RKAEEVRKAEELRKAEDARKAEAA-----RKAEEER 1212
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1111 GLVAQLQKTVKELQTQIKDLKE-KLEAERTTRAKMERERADLTQDLADLNERLEEVGGSSLAQlEITKKQETKFQKLHRD 1189
Cdd:PTZ00121 1213 KAEEARKAEDAKKAEAVKKAEEaKKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAE-EARKADELKKAEEKKK 1291
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1190 MEEATLHFETTSASLKKRHADSLAELEGQVENLQQVKQKLE--KDKSDLQLEVDDLLTRVEQMTRAKAN-AEKLCTLYEE 1266
Cdd:PTZ00121 1292 ADEAKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADaaKKKAEEAKKAAEAAKAEAEAAADEAEaAEEKAEAAEK 1371
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1267 RLHEATAKLDKVTQLAN-----DLAAQKTKLWSESGEFLRRLEEKEALINQLsREKSNFTRQIEDLRGQLEKETKSQSAL 1341
Cdd:PTZ00121 1372 KKEEAKKKADAAKKKAEekkkaDEAKKKAEEDKKKADELKKAAAAKKKADEA-KKKAEEKKKADEAKKKAEEAKKADEAK 1450
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1342 AHALQKaqRDCDLLREQYEEEQEVKAELHRTLSKVNAEMVQWRMKYENNVIQRTEDLEDAKKElAIRLQEAAEAMGVANA 1421
Cdd:PTZ00121 1451 KKAEEA--KKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKK-ADEAKKAEEAKKADEA 1527
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1422 RNAS----LERARHQLQLELGDALSDLGKVRSAAARldQKQLQSGKALAD---WKQKHEESQALLDASQKEVQALSTELL 1494
Cdd:PTZ00121 1528 KKAEeakkADEAKKAEEKKKADELKKAEELKKAEEK--KKAEEAKKAEEDknmALRKAEEAKKAEEARIEEVMKLYEEEK 1605
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1495 KLK----NTYEESIVGQETLRREnknlQEEISNLTNQVREGTKNLTEMEKVKKliEEEKTEVQVTLEETEGALERNESKI 1570
Cdd:PTZ00121 1606 KMKaeeaKKAEEAKIKAEELKKA----EEEKKKVEQLKKKEAEEKKKAEELKK--AEEENKIKAAEEAKKAEEDKKKAEE 1679
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1571 LHFQLELLEAKAELERKLSEKDEEIENFRRKQQCTIDSLQSSLDSEAKSRIEVTRLKKKMEEDlnemelqlscaNRQVSE 1650
Cdd:PTZ00121 1680 AKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEED-----------KKKAEE 1748
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1651 ATKSLGQlqiQIKDLQMQLDDSTQLNSDLKEQVAVAERRnslLQSELEDLRSLQEQTERGRRLSEEELLEATERINLFYT 1730
Cdd:PTZ00121 1749 AKKDEEE---KKKIAHLKKEEEKKAEEIRKEKEAVIEEE---LDEEDEKRRMEVDKKIKDIFDNFANIIEGGKEGNLVIN 1822
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1731 QNTSLLSQKKKLEADVARMQK-EAEEVVQECQNAEEKAKKAAIEAANLSEELKKKQDTIAHLERTRENMEQTITDLQKRL 1809
Cdd:PTZ00121 1823 DSKEMEDSAIKEVADSKNMQLeEADAFEKHKFNKNNENGEDGNKEADFNKEKDLKEDDEEEIEEADEIEKIDKDDIEREI 1902

                  .
gi 767926067 1810 A 1810
Cdd:PTZ00121 1903 P 1903
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
988-1880 4.21e-14

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 78.47  E-value: 4.21e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   988 KNLTEEVEFLNEDISKLNRAAKVVQEAHQQTLDDLHMEEEKLSSLSKAnlklEQQVDELEGALEQERKARMNCERELHKL 1067
Cdd:pfam02463  156 LEIEEEAAGSRLKRKKKEALKKLIEETENLAELIIDLEELKLQELKLK----EQAKKALEYYQLKEKLELEEEYLLYLDY 231
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1068 egnLKLNRESMENLEssqrhlaEELRKKELELSQMNSKVENEKGLVAQLQKTVKELQTQIKDLKEKLEAERTTRAKMERE 1147
Cdd:pfam02463  232 ---LKLNEERIDLLQ-------ELLRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSE 301
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1148 RADLTQDLADLNERLEEvggsslAQLEITKKQEtkfqklhrdmeeatlhfettsaslkkrhadSLAELEGQVENLQQVKQ 1227
Cdd:pfam02463  302 LLKLERRKVDDEEKLKE------SEKEKKKAEK------------------------------ELKKEKEEIEELEKELK 345
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1228 KLEKDKSDLQLEVDDLLTRVEQMTRAKANAEKLCTLYEERLHEATAKLDKVTQLANDLAAQKTklwSESGEFLRRLEEKE 1307
Cdd:pfam02463  346 ELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELELKSEEEKEAQ---LLLELARQLEDLLK 422
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1308 ALINQLSREKSNFTRQIEDLRGQLEKETKSQSALAHALQKAQRDCDLLREQYEEEQEVKAELHRTL----SKVNAEMVQW 1383
Cdd:pfam02463  423 EEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLLKDELELKKSEDLLKETQLVKLQEQLELllsrQKLEERSQKE 502
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1384 RMKYENN------VIQRTEDLEDAKKELAIRLQEAAEAMGVANarNASLERARHQLQLELGDALSDLGKVRSAAARLDQK 1457
Cdd:pfam02463  503 SKARSGLkvllalIKDGVGGRIISAHGRLGDLGVAVENYKVAI--STAVIVEVSATADEVEERQKLVRALTELPLGARKL 580
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1458 QLQSGKALADWKQKHEESQALLDASQKEVQALSTELLKLKN-----TYEESIVGQETLRRENKNLQEEISNLTNQVREGT 1532
Cdd:pfam02463  581 RLLIPKLKLPLKSIAVLEIDPILNLAQLDKATLEADEDDKRakvveGILKDTELTKLKESAKAKESGLRKGVSLEEGLAE 660
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1533 KNLTEMEKVKKLIEEEKTEVQVTLEETEGALERNESKILHFQLELLEAKAELERKLSEKDEEIENFRRKQQCTIDSLQSS 1612
Cdd:pfam02463  661 KSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEIKKKEQREKEELKKLKLEAEELLADRVQEAQDKINEELKL 740
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1613 LDSEAKSRIEV---TRLKKKMEEDLNEMELQLSCANRQVSEATKSLGQLQIQIKDLQMQLDDSTQLNSDLKEQVAVAERR 1689
Cdd:pfam02463  741 LKQKIDEEEEEeekSRLKKEEKEEEKSELSLKEKELAEEREKTEKLKVEEEKEEKLKAQEEELRALEEELKEEAELLEEE 820
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1690 NSLLQSELEDLRSLQEQ-------TERGRRLSEEELLEATERINLFYTQNTSLLSQKKKLEADVARMQKEAEEVVQECQN 1762
Cdd:pfam02463  821 QLLIEQEEKIKEEELEElalelkeEQKLEKLAEEELERLEEEITKEELLQELLLKEEELEEQKLKDELESKEEKEKEEKK 900
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1763 AEEKAKKAAIEAANLSEELKKKQDTIAHLERTRENMEQTITDLQKRLAEAEQMALMGSRKQIQKLESRVRELEGELEGEI 1842
Cdd:pfam02463  901 ELEEESQKLNLLEEKENEIEERIKEEAEILLKYEEEPEELLLEEADEKEKEENNKEEEEERNKRLLLAKEELGKVNLMAI 980
                          890       900       910
                   ....*....|....*....|....*....|....*...
gi 767926067  1843 RRSAEAQRGARRLERCIKELTYQAEEDKKNLSRMQTQM 1880
Cdd:pfam02463  981 EEFEEKEERYNKDELEKERLEEEKKKLIRAIIEETCQR 1018
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1042-1725 1.27e-13

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 76.64  E-value: 1.27e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1042 QVDELEGALEQERKARMNCERELHKLEGNLKlnreSMENLESSQRHLAEELRKKELELSQMNSKVENEKGLVAQLQKTVK 1121
Cdd:PRK03918  156 GLDDYENAYKNLGEVIKEIKRRIERLEKFIK----RTENIEELIKEKEKELEEVLREINEISSELPELREELEKLEKEVK 231
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1122 ELqtqiKDLKEKLEAERTTRAKMERERADLTQDLADLNERLEEVggsslaqleitKKQETKFQKLHRDMEEAtlhfetts 1201
Cdd:PRK03918  232 EL----EELKEEIEELEKELESLEGSKRKLEEKIRELEERIEEL-----------KKEIEELEEKVKELKEL-------- 288
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1202 aslkKRHADSLAELEGQVENLQQVKQKLEKDKSDLQLEVDDLLTRVEQMTRAKANAEKLCTLYEE------RLHEATAKL 1275
Cdd:PRK03918  289 ----KEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKELEEKEERLEELKKKLKElekrleELEERHELY 364
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1276 DKVTQLANDLAAQKTKLWSESgeflrrLEEKEALINQLSREKSNFTRQIEDL---RGQLEKETKSQSALAHALQKAQRDC 1352
Cdd:PRK03918  365 EEAKAKKEELERLKKRLTGLT------PEKLEKELEELEKAKEEIEEEISKItarIGELKKEIKELKKAIEELKKAKGKC 438
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1353 DLLREQYEEEQ--EVKAELHRTLSKVNAEMvqwrmkyennvIQRTEDLEDAKKELairlqeaaeamgvanaRNASLERAR 1430
Cdd:PRK03918  439 PVCGRELTEEHrkELLEEYTAELKRIEKEL-----------KEIEEKERKLRKEL----------------RELEKVLKK 491
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1431 HQLQLELGDALSDLGKVRSAAARLDQKQLQsgkalADWKqKHEESQALLDASQKEVQALSTELLKLKNTYEESivgqETL 1510
Cdd:PRK03918  492 ESELIKLKELAEQLKELEEKLKKYNLEELE-----KKAE-EYEKLKEKLIKLKGEIKSLKKELEKLEELKKKL----AEL 561
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1511 RRENKNLQEEISNLTNQVRE-GTKNLTEMEKVKKLIEEEKTEVqVTLEETEGALERNESKILHFQLELLEAKAELErkls 1589
Cdd:PRK03918  562 EKKLDELEEELAELLKELEElGFESVEELEERLKELEPFYNEY-LELKDAEKELEREEKELKKLEEELDKAFEELA---- 636
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1590 EKDEEIENFRRKqqctIDSLQSSLDSEAKSRIEVTRLKKKMEedLNEMELQLSCANRQVSEATKSLGQLQIQikdlqmql 1669
Cdd:PRK03918  637 ETEKRLEELRKE----LEELEKKYSEEEYEELREEYLELSRE--LAGLRAELEELEKRREEIKKTLEKLKEE-------- 702
                         650       660       670       680       690
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 767926067 1670 ddstqlnsdlKEQVAVAERRNSLLQSELEDLRSLQEQTERGRRLSEEELLEATERI 1725
Cdd:PRK03918  703 ----------LEEREKAKKELEKLEKALERVEELREKVKKYKALLKERALSKVGEI 748
PTZ00121 PTZ00121
MAEBL; Provisional
1216-1945 1.46e-13

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 76.72  E-value: 1.46e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1216 EGQVENLQQVKQKLEKDKSDLQLEVDDLLTRVEQMT--RAKANAEKLCTLYEERLHEATAKLDKVTQLANDLAAQKTKlw 1293
Cdd:PTZ00121 1057 EGKAEAKAHVGQDEGLKPSYKDFDFDAKEDNRADEAteEAFGKAEEAKKTETGKAEEARKAEEAKKKAEDARKAEEAR-- 1134
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1294 seSGEFLRRLEEKEALINQlsrEKSNFTRQIEDLRGQLEKETKSQSALAHALQKAQ--RDCDLLREQYEE---EQEVKAE 1368
Cdd:PTZ00121 1135 --KAEDARKAEEARKAEDA---KRVEIARKAEDARKAEEARKAEDAKKAEAARKAEevRKAEELRKAEDArkaEAARKAE 1209
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1369 LHRTLSKVNAEMVQWRMKYENNVIQRTEDLEDAKKELAIRLQEaaEAMGVANARNASLERARHQLQLELGDALSDLGKVR 1448
Cdd:PTZ00121 1210 EERKAEEARKAEDAKKAEAVKKAEEAKKDAEEAKKAEEERNNE--EIRKFEEARMAHFARRQAAIKAEEARKADELKKAE 1287
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1449 SAAARLDQKQLQSGKALADWKQKHEESQALlDASQKEVQALSTELLKLKNTYEESIVGQETLRRENKNLQEEISNlTNQV 1528
Cdd:PTZ00121 1288 EKKKADEAKKAEEKKKADEAKKKAEEAKKA-DEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEA-AEEK 1365
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1529 REGTKNLTEMEKVKKLIEEEKTEVQVTLEETEGALERNESKIlhfqlELLEAKAELERKLSEKDEEIENFRRKQQCTIDS 1608
Cdd:PTZ00121 1366 AEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKA-----DELKKAAAAKKKADEAKKKAEEKKKADEAKKKA 1440
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1609 LQSSLDSEAKSRIEVTR----LKKKMEEDLNEMELQLSCAN-RQVSEATKSLGQLQIQIKDLQMQLDDSTQLNSDLK--E 1681
Cdd:PTZ00121 1441 EEAKKADEAKKKAEEAKkaeeAKKKAEEAKKADEAKKKAEEaKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKaeE 1520
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1682 QVAVAERRNSLLQSELEDLRSLQEQTERGRRLSEEELLEATERinlfytqntSLLSQKKKLEADVARMQKEAEEVVQ-EC 1760
Cdd:PTZ00121 1521 AKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEK---------KKAEEAKKAEEDKNMALRKAEEAKKaEE 1591
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1761 QNAEEKAKKAAIEAANLSEELKKKQDTIAHLERTRENMEQTITDLQKRLAEAEQMALMGSRKQIQKLESRVRELEGELEG 1840
Cdd:PTZ00121 1592 ARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAE 1671
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1841 EIRRSAEAQRGARRLERCIKELTYQAEEDKKNLSRMQTQMDKLQLKVQNYKQQVEVAETQANQylskYKKQQHELNEVKE 1920
Cdd:PTZ00121 1672 EDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEE----AKKEAEEDKKKAE 1747
                         730       740
                  ....*....|....*....|....*
gi 767926067 1921 RAEVAESQVNKLKIKAREFGKKVQE 1945
Cdd:PTZ00121 1748 EAKKDEEEKKKIAHLKKEEEKKAEE 1772
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
865-1754 1.99e-13

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 76.16  E-value: 1.99e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   865 KEECAQLQKALEKSEFQREELKAKQVSLTQEKNDLILQL-QAEQETLANVEEqcewliksKIQLEARVKelserveeeee 943
Cdd:pfam02463  221 LEEEYLLYLDYLKLNEERIDLLQELLRDEQEEIESSKQEiEKEEEKLAQVLK--------ENKEEEKEK----------- 281
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   944 inSELTARGRKLEDECFELKKEIDDLETMLVKSEKEKRTTEHKVKNLTEEVEFLNEDISKLNRAAKVVQEAHQQTLDdlh 1023
Cdd:pfam02463  282 --KLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKEKKKAEKELKKEKEEIEELEKELKELEIKREAEEE--- 356
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1024 mEEEKLSSLSKANLKLEQQVDELEGALEQERKARMNCERELHKLEGNLKLNRESMENLESSQRHLAEELRKKELELSQMN 1103
Cdd:pfam02463  357 -EEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELELKSEEEKEAQLLLELARQLEDLLKEEKKEELEILEEE 435
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1104 SKVENEKGLVAQLQKTVKELQTQIKDLKEKLEAERTTRAKMERERADLTQDLADLNERLEEVGGSSLAQLEITKKQETKF 1183
Cdd:pfam02463  436 EESIELKQGKLTEEKEELEKQELKLLKDELELKKSEDLLKETQLVKLQEQLELLLSRQKLEERSQKESKARSGLKVLLAL 515
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1184 QKLHRDMEEATLHFETTSASLKKRHADSLAELEGQVENLQQVKQKLEKDKSDLQLEV--DDLLTRVEQMTRAKANAEKLC 1261
Cdd:pfam02463  516 IKDGVGGRIISAHGRLGDLGVAVENYKVAISTAVIVEVSATADEVEERQKLVRALTElpLGARKLRLLIPKLKLPLKSIA 595
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1262 TLYEERLHEATAKldkvtQLANDLAAQKTKLWSESGEFLRRLEEKEALINQLSREKSNFTRQIEDLRGQLEKETKSQSAL 1341
Cdd:pfam02463  596 VLEIDPILNLAQL-----DKATLEADEDDKRAKVVEGILKDTELTKLKESAKAKESGLRKGVSLEEGLAEKSEVKASLSE 670
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1342 AHALQKAQRDCDLLREQYEEEQEVKAELHRTLSKVNAEMVQWRMKYEnnviQRTEDLEDAKKELAIRLQEaaeamgvaNA 1421
Cdd:pfam02463  671 LTKELLEIQELQEKAESELAKEEILRRQLEIKKKEQREKEELKKLKL----EAEELLADRVQEAQDKINE--------EL 738
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1422 RNASLERARHQLQLELGDALSDLGKVRSAAARLDQKQLQSGKALADWKQKHEESQALLDASQKEVQALSTELLKLKNTYE 1501
Cdd:pfam02463  739 KLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKELAEEREKTEKLKVEEEKEEKLKAQEEELRALEEELKEEAELLE 818
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1502 ESIvgqetlrrENKNLQEEISNLTNQvrEGTKNLTEMEKVKKLIEEEKTEVQVTLEETEGALERNESKILHFQLELLEAK 1581
Cdd:pfam02463  819 EEQ--------LLIEQEEKIKEEELE--ELALELKEEQKLEKLAEEELERLEEEITKEELLQELLLKEEELEEQKLKDEL 888
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1582 AELERKLSEKDEEIENFRRkqqctIDSLQSSLDSEAKSRIEVTRLKKKMEEDLNEMELqLSCANRQVSEATKSLGQLQIQ 1661
Cdd:pfam02463  889 ESKEEKEKEEKKELEEESQ-----KLNLLEEKENEIEERIKEEAEILLKYEEEPEELL-LEEADEKEKEENNKEEEEERN 962
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1662 IKDLQMQLDDSTQLNSDLKEQVAVAERRNsllqSELEDLRSLQEQTERGRRLSEEELLEATERINLFYTQNTSLLSQKKK 1741
Cdd:pfam02463  963 KRLLLAKEELGKVNLMAIEEFEEKEERYN----KDELEKERLEEEKKKLIRAIIEETCQRLKEFLELFVSINKGWNKVFF 1038
                          890
                   ....*....|...
gi 767926067  1742 LEADVARMQKEAE 1754
Cdd:pfam02463 1039 YLELGGSAELRLE 1051
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
1547-1862 2.71e-13

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 75.86  E-value: 2.71e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1547 EEKTEVQVTLEETEGALERNESKI--LHFQLELLEAKAELERKLSEKDEEIENFRrkqqctIDSLQSSLDSEAKSRIEVT 1624
Cdd:TIGR02168  172 ERRKETERKLERTRENLDRLEDILneLERQLKSLERQAEKAERYKELKAELRELE------LALLVLRLEELREELEELQ 245
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1625 RLKKKMEEDLNEMELQLSCANRQVSEATKSLGQLQIQIKDLQMQLDDSTQLNSDLKEQVAVAERRNSLLQSELEDLRSLQ 1704
Cdd:TIGR02168  246 EELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQL 325
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1705 EQTERGRRLSEEELLEATERINLFYTQNTSLLSQKKKLEADVARMQKEAEEVVQECQNAEEKAKKAAIEAANLSEELKKK 1784
Cdd:TIGR02168  326 EELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERL 405
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1785 QDTIAHLERTRENMEQTITDLQKRLAEAE----QMALMGSRKQIQKLESRVRELEGELEGEIRRSAEAQRGARRLERCIK 1860
Cdd:TIGR02168  406 EARLERLEDRRERLQQEIEELLKKLEEAElkelQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELA 485

                   ..
gi 767926067  1861 EL 1862
Cdd:TIGR02168  486 QL 487
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
1115-1873 4.30e-13

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 75.15  E-value: 4.30e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1115 QLQKTVKELQTQIKDLKEKLEAERTTRakmERERADLTQDLADLNERLEEVGGSSLAQLEItKKQETKFQKLHRDMEEAT 1194
Cdd:pfam15921   75 HIERVLEEYSHQVKDLQRRLNESNELH---EKQKFYLRQSVIDLQTKLQEMQMERDAMADI-RRRESQSQEDLRNQLQNT 150
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1195 LHFETTSASLKKrhaDSLAELEGQVENLQQVKQKLEkdksDLQLEVDDLLTRVEQMTRAKA-NAEKLCTLYEERLHEATA 1273
Cdd:pfam15921  151 VHELEAAKCLKE---DMLEDSNTQIEQLRKMMLSHE----GVLQEIRSILVDFEEASGKKIyEHDSMSTMHFRSLGSAIS 223
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1274 KLdkVTQLANDLAAQKTKLWSESGEFLRRLEEKEALINQLSREKSNftrQIEDLRGQLEKET-----KSQSALAHAlQKA 1348
Cdd:pfam15921  224 KI--LRELDTEISYLKGRIFPVEDQLEALKSESQNKIELLLQQHQD---RIEQLISEHEVEItglteKASSARSQA-NSI 297
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1349 QRDCDLLREQYEEEQEVK----AELHRTLSKVNAEMVQWRMKYENNViqrtedlEDAKKELAIRLQEAAEAmgvaNARNA 1424
Cdd:pfam15921  298 QSQLEIIQEQARNQNSMYmrqlSDLESTVSQLRSELREAKRMYEDKI-------EELEKQLVLANSELTEA----RTERD 366
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1425 SLERARHQLQLELGDALSDLGKvRSAAARLDQKQlqsGKALadWKQKHEESQAL------LDASQKEVQALSTELLKLKN 1498
Cdd:pfam15921  367 QFSQESGNLDDQLQKLLADLHK-REKELSLEKEQ---NKRL--WDRDTGNSITIdhlrreLDDRNMEVQRLEALLKAMKS 440
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1499 TYEESIVGQ-ETLRRENKNLqEEISNLTNQV---REGTKNLTEMEKVKKLIEE--EKT--EVQVTLEETEGALERNESKI 1570
Cdd:pfam15921  441 ECQGQMERQmAAIQGKNESL-EKVSSLTAQLestKEMLRKVVEELTAKKMTLEssERTvsDLTASLQEKERAIEATNAEI 519
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1571 L--------------HFQLE---LLEAKAE---LERKLSEKDEEIENFRRKqqctIDSLQSSLDSEAKSRIEVTRLKKKM 1630
Cdd:pfam15921  520 TklrsrvdlklqelqHLKNEgdhLRNVQTEceaLKLQMAEKDKVIEILRQQ----IENMTQLVGQHGRTAGAMQVEKAQL 595
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1631 EEDLNEMELQLSCANRQVSEATKSLGQLQIQIKDLQMQLDDSTQLNSD-LKEQVAVAERRNSLL------QSELEDLRSL 1703
Cdd:pfam15921  596 EKEINDRRLELQEFKILKDKKDAKIRELEARVSDLELEKVKLVNAGSErLRAVKDIKQERDQLLnevktsRNELNSLSED 675
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1704 QEQTERGRRLSEEELLEATERINLFYTQNTSLLSQK----KKLEADVARMQKEAEEVVQECQNAEEKAKKAAIEAANLSE 1779
Cdd:pfam15921  676 YEVLKRNFRNKSEEMETTTNKLKMQLKSAQSELEQTrntlKSMEGSDGHAMKVAMGMQKQITAKRGQIDALQSKIQFLEE 755
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1780 ELKKKQDTIAHLERTRENMEQTITDLQkrlAEAEQMA--LMGSRKQIQKLESRVRELEGELEGEIRRSAEAQRGARRLER 1857
Cdd:pfam15921  756 AMTNANKEKHFLKEEKNKLSQELSTVA---TEKNKMAgeLEVLRSQERRLKEKVANMEVALDKASLQFAECQDIIQRQEQ 832
                          810
                   ....*....|....*.
gi 767926067  1858 CIKELTYQAEEDKKNL 1873
Cdd:pfam15921  833 ESVRLKLQHTLDVKEL 848
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
847-1292 7.64e-13

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 73.94  E-value: 7.64e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  847 KIKPLVKSSEVGEEVAGLKEECAQLQKALEKSEFQREELKAKQVSLTQEKNDLILQLqaeqETLANVEEQCEWLIKSKIQ 926
Cdd:PRK03918  274 EIEELEEKVKELKELKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEERI----KELEEKEERLEELKKKLKE 349
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  927 LEARVKELSERVeeeeeinsELTARGRKLEDECFELKK-----EIDDLETMLVKSEKEKRTTEHKVKNLTEEVEFLNEDI 1001
Cdd:PRK03918  350 LEKRLEELEERH--------ELYEEAKAKKEELERLKKrltglTPEKLEKELEELEKAKEEIEEEISKITARIGELKKEI 421
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1002 SKLNRAAKVVQEAHQQ--TLDDLHMEEEKLSSLSKANLKLEQQVDELEGALEQERKARmnceRELHKLEGNLKLNRESme 1079
Cdd:PRK03918  422 KELKKAIEELKKAKGKcpVCGRELTEEHRKELLEEYTAELKRIEKELKEIEEKERKLR----KELRELEKVLKKESEL-- 495
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1080 nleSSQRHLAEELRKKELELSQMN-SKVENEKGLVAQLQKTVKELQTQIKDLK---EKLEAERTTRAKMERERADLTQDL 1155
Cdd:PRK03918  496 ---IKLKELAEQLKELEEKLKKYNlEELEKKAEEYEKLKEKLIKLKGEIKSLKkelEKLEELKKKLAELEKKLDELEEEL 572
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1156 ADLNERLEEVGGSSLAQLEITKKQETKFQKLHRDMEEATLHFEttsaSLKKRHADSLAELEGQVENLQQVKQKLEKDKSD 1235
Cdd:PRK03918  573 AELLKELEELGFESVEELEERLKELEPFYNEYLELKDAEKELE----REEKELKKLEEELDKAFEELAETEKRLEELRKE 648
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 767926067 1236 L-QLEVDDLLTRVEQMTRAKANAEKLCTLYEERLHEATAKLDKVTQLANDLAAQKTKL 1292
Cdd:PRK03918  649 LeELEKKYSEEEYEELREEYLELSRELAGLRAELEELEKRREEIKKTLEKLKEELEER 706
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
954-1662 1.49e-12

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 73.08  E-value: 1.49e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   954 KLEDECFELKKEIDDLETMLVKSEKEKRTTEHKVKNLTEEVEFLNEDISKLNRAAKVVQEAH--QQTLDDLHMEEEKLSS 1031
Cdd:TIGR00618  195 KAELLTLRSQLLTLCTPCMPDTYHERKQVLEKELKHLREALQQTQQSHAYLTQKREAQEEQLkkQQLLKQLRARIEELRA 274
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1032 ----LSKANLKLEQQVDELEGALEQER---------------KARMNC-ERELHKLEGNLKLNRESMENLESSQRHLAEE 1091
Cdd:TIGR00618  275 qeavLEETQERINRARKAAPLAAHIKAvtqieqqaqrihtelQSKMRSrAKLLMKRAAHVKQQSSIEEQRRLLQTLHSQE 354
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1092 LRKKELELSQMNSKVENEKGLvaQLQKTVKELQTQIKDLKEKLEAERTTRAKMERERAdlTQDLADLNERLEEvggsslA 1171
Cdd:TIGR00618  355 IHIRDAHEVATSIREISCQQH--TLTQHIHTLQQQKTTLTQKLQSLCKELDILQREQA--TIDTRTSAFRDLQ------G 424
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1172 QLEITKKQEtKFQKLHRDMEEATLHFETTSASLKKRHADSLAE-LEGQVENLQQVKQKLEKDKSdlqlevddllTRVEQM 1250
Cdd:TIGR00618  425 QLAHAKKQQ-ELQQRYAELCAAAITCTAQCEKLEKIHLQESAQsLKEREQQLQTKEQIHLQETR----------KKAVVL 493
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1251 TRAKANAEKLCTLYEERLHeatakldkvtqlandlAAQKTKLWSESGEFLRRLEEKEALINQLSREksnftrqIEDLRGQ 1330
Cdd:TIGR00618  494 ARLLELQEEPCPLCGSCIH----------------PNPARQDIDNPGPLTRRMQRGEQTYAQLETS-------EEDVYHQ 550
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1331 LEKETKSQSALAHALQKAQRDCDLLREQYeeeQEVKAELHRTLSKVNaEMVQWRMKYENNVIQRTEDL--EDAKKELAIR 1408
Cdd:TIGR00618  551 LTSERKQRASLKEQMQEIQQSFSILTQCD---NRSKEDIPNLQNITV-RLQDLTEKLSEAEDMLACEQhaLLRKLQPEQD 626
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1409 LQEAAEAMGVANARNASLERARHQLQLELgdaLSDLGKVRSAAARLDQKQLQSGKALADWKQKHEESQA-----LLDASQ 1483
Cdd:TIGR00618  627 LQDVRLHLQQCSQELALKLTALHALQLTL---TQERVREHALSIRVLPKELLASRQLALQKMQSEKEQLtywkeMLAQCQ 703
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1484 KEVQALSTELLKLKNTYEE----SIVGQETLRRENKNLQEEISNLTNQVREGTKNLTEMEKVKKLIEEEKTEVQVTLEET 1559
Cdd:TIGR00618  704 TLLRELETHIEEYDREFNEienaSSSLGSDLAAREDALNQSLKELMHQARTVLKARTEAHFNNNEEVTAALQTGAELSHL 783
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1560 EGALERNESKILHFQLELLEAKAELERKLSEKDEEIENFRRKQQCTIDSLQSSLDSEAKSRIEVTRLKKKMEEDLNEMEl 1639
Cdd:TIGR00618  784 AAEIQFFNRLREEDTHLLKTLEAEIGQEIPSDEDILNLQCETLVQEEEQFLSRLEEKSATLGEITHQLLKYEECSKQLA- 862
                          730       740
                   ....*....|....*....|....*.
gi 767926067  1640 QLSCANRQVSEATKSLG---QLQIQI 1662
Cdd:TIGR00618  863 QLTQEQAKIIQLSDKLNginQIKIQF 888
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
864-1515 1.52e-12

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 72.83  E-value: 1.52e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   864 LKEECAQLQKALEKSEFQREELKAKQVSLTQEKNDLILQLQAEQETLANVEEQCEWLIKskiqlEARVKELSERVEEEEE 943
Cdd:pfam05483  160 LKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMILAFEELRVQAENARLEMHFKLK-----EDHEKIQHLEEEYKKE 234
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   944 INSElTARGRKLEDECFELKKEIDDLETMLVKSEKEKRTTEHKVKNLTEEVEFLNEDISKLNRAAKVVQEAHQQTLDDLH 1023
Cdd:pfam05483  235 INDK-EKQVSLLLIQITEKENKMKDLTFLLEESRDKANQLEEKTKLQDENLKELIEKKDHLTKELEDIKMSLQRSMSTQK 313
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1024 MEEEKLSSLSKAnlkLEQQVDELEGALEQERKAR-------MNCERELHKLEGNLKLNRESMENLESSQRHLAEELRKKE 1096
Cdd:pfam05483  314 ALEEDLQIATKT---ICQLTEEKEAQMEELNKAKaahsfvvTEFEATTCSLEELLRTEQQRLEKNEDQLKIITMELQKKS 390
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1097 LELSQMNSKVENEKGLVAQLQKTVKElqtqikdlKEKLEAERTTRAKMERERADLTQDLADLNERLEEVGGSSLAQLEIT 1176
Cdd:pfam05483  391 SELEEMTKFKNNKEVELEELKKILAE--------DEKLLDEKKQFEKIAEELKGKEQELIFLLQAREKEIHDLEIQLTAI 462
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1177 KKQETKFQKLHRDMEEatlhfETTSASLKKrhadslAELEGQVENLQQVKQKLEKDKSDLQLEvddLLTRVEQMTRAKAN 1256
Cdd:pfam05483  463 KTSEEHYLKEVEDLKT-----ELEKEKLKN------IELTAHCDKLLLENKELTQEASDMTLE---LKKHQEDIINCKKQ 528
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1257 AEKLctlyeerLHEATAKLDKVTQLANDLAAQKTKLWSESGEFLRRLEEKEALINQLSREKSNFTRQIEDLRGQLEKETK 1336
Cdd:pfam05483  529 EERM-------LKQIENLEEKEMNLRDELESVREEFIQKGDEVKCKLDKSEENARSIEYEVLKKEKQMKILENKCNNLKK 601
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1337 SQSALAHALQKAQRDCDLLREQYEEEQEVKAELHRTLSKVNAEMVQWRMKYENNVIQRTEDLEDAKKELAIRLQEAAEAM 1416
Cdd:pfam05483  602 QIENKNKNIEELHQENKALKKKGSAENKQLNAYEIKVNKLELELASAKQKFEEIIDNYQKEIEDKKISEEKLLEEVEKAK 681
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1417 GVANARNASLERARHQLQLELGDALSDLGKVRSaaaRLDQKQLQSGKALADWKQKHEESQALLDASQKEVQALSTELLKL 1496
Cdd:pfam05483  682 AIADEAVKLQKEIDKRCQHKIAEMVALMEKHKH---QYDKIIEERDSELGLYKNKEQEQSSAKAALEIELSNIKAELLSL 758
                          650
                   ....*....|....*....
gi 767926067  1497 KNTYEESIVGQETLRRENK 1515
Cdd:pfam05483  759 KKQLEIEKEEKEKLKMEAK 777
PTZ00121 PTZ00121
MAEBL; Provisional
974-1607 1.62e-12

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 73.25  E-value: 1.62e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  974 VKSEKEKRTTEHKVKnlTEEVEFLNEDISKLNRAAKVVQEAHQQTLDDLHMEEEKLSSLSKANLKLEQQVDELEGALEQE 1053
Cdd:PTZ00121 1289 KKKADEAKKAEEKKK--ADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKA 1366
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1054 RKARMNCERELHKLEGNLKLNRESMENLESSQRhlAEELRKK--ELELSQMNSKVENEKGLVAQLQKTVKELQTQIKDLK 1131
Cdd:PTZ00121 1367 EAAEKKKEEAKKKADAAKKKAEEKKKADEAKKK--AEEDKKKadELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAK 1444
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1132 EKLEAERTTRAKMERERADLTQDLADLNERLEEVGGSSLAQLEITKKQETKFQKLH--RDMEEATLHFETTSASLKKRHA 1209
Cdd:PTZ00121 1445 KADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADeaKKAAEAKKKADEAKKAEEAKKA 1524
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1210 DSL--AELEGQVENLQQV--KQKLEKDKSDLQLEVDDLLTRVEQMTRAKAN-------AEKLCTLYEERLHEATaKLDKV 1278
Cdd:PTZ00121 1525 DEAkkAEEAKKADEAKKAeeKKKADELKKAEELKKAEEKKKAEEAKKAEEDknmalrkAEEAKKAEEARIEEVM-KLYEE 1603
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1279 TQLANDLAAQKTKLWSESGEFLRRLEEKEALINQLSREKSNFTRQIEDLRGQLEKETKSQSALAHALQKAQRDCDLLREq 1358
Cdd:PTZ00121 1604 EKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKK- 1682
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1359 yEEEQEVKAELHRTLSKVNAEMVQWRMKYENNVIQRTEDLEDAKKELAIRLQEAA-----EAMGVANARNASLERAR-HQ 1432
Cdd:PTZ00121 1683 -AEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKkeaeeDKKKAEEAKKDEEEKKKiAH 1761
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1433 LQLELGDALSDLGKVRSAAAR--LDQK----QLQSGKALADWKQKHE--------------ESQALLDASQKEVQALSTE 1492
Cdd:PTZ00121 1762 LKKEEEKKAEEIRKEKEAVIEeeLDEEdekrRMEVDKKIKDIFDNFAniieggkegnlvinDSKEMEDSAIKEVADSKNM 1841
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1493 LLKLKNTYEESIVGQETLRRENKNLQEEISNLTNQVREGTKNLTEMEKVKKLIEEEktevqVTLEETEGALERNESKILH 1572
Cdd:PTZ00121 1842 QLEEADAFEKHKFNKNNENGEDGNKEADFNKEKDLKEDDEEEIEEADEIEKIDKDD-----IEREIPNNNMAGKNNDIID 1916
                         650       660       670
                  ....*....|....*....|....*....|....*
gi 767926067 1573 FQLELLEAKaelERKLSEKDEEIENFRRKQQCTID 1607
Cdd:PTZ00121 1917 DKLDKDEYI---KRDAEETREEIIKISKKDMCIND 1948
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1037-1595 1.62e-12

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 72.79  E-value: 1.62e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1037 LKLEQQVDELEGALEQERKARmncERELHKLEGNLKLNRESMENLESSQRHL---AEELRKKELELSQMNSKVENEKGLV 1113
Cdd:PRK03918  185 IKRTENIEELIKEKEKELEEV---LREINEISSELPELREELEKLEKEVKELeelKEEIEELEKELESLEGSKRKLEEKI 261
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1114 AQLQKTVKELQTQIKDLKEK--------------------LEAERTTRAKMERERADLTQDLADLNERLEEvGGSSLAQL 1173
Cdd:PRK03918  262 RELEERIEELKKEIEELEEKvkelkelkekaeeyiklsefYEEYLDELREIEKRLSRLEEEINGIEERIKE-LEEKEERL 340
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1174 EITKKQETKFQKLHRDMEEATLHFETTSA------SLKKRHAD-SLAELEGQVENLQQVKQKLEKDKSDLQLEVDDLLTR 1246
Cdd:PRK03918  341 EELKKKLKELEKRLEELEERHELYEEAKAkkeeleRLKKRLTGlTPEKLEKELEELEKAKEEIEEEISKITARIGELKKE 420
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1247 VEQMTRAKA---NAEKLCTLYEERLHEATAK--LDKVTQLANDLAAQKTKLWSESGEFLRRLEEKEALINQLSREKSNft 1321
Cdd:PRK03918  421 IKELKKAIEelkKAKGKCPVCGRELTEEHRKelLEEYTAELKRIEKELKEIEEKERKLRKELRELEKVLKKESELIKL-- 498
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1322 RQIEDLRGQLEKETKSqsalaHALQKAQRDCDLLREQYEEEQEVKAELHRTLSKVNaemvqwrmkyennviqRTEDLEDA 1401
Cdd:PRK03918  499 KELAEQLKELEEKLKK-----YNLEELEKKAEEYEKLKEKLIKLKGEIKSLKKELE----------------KLEELKKK 557
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1402 KKELAIRLQEAAEAMGVANAR-----NASLERARHQLQlELGDALSDLGKVRSAAARLDQKQlqsgKALADWKQKHEESQ 1476
Cdd:PRK03918  558 LAELEKKLDELEEELAELLKEleelgFESVEELEERLK-ELEPFYNEYLELKDAEKELEREE----KELKKLEEELDKAF 632
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1477 ALLDASQKEVQALSTELLKLKNTYEESivGQETLRRENKNLQEEISNLTNQVREGTKNLTEMEKVKKLIEEEKTEVQVTL 1556
Cdd:PRK03918  633 EELAETEKRLEELRKELEELEKKYSEE--EYEELREEYLELSRELAGLRAELEELEKRREEIKKTLEKLKEELEEREKAK 710
                         570       580       590
                  ....*....|....*....|....*....|....*....
gi 767926067 1557 EETEgALERNESKILHFQLELLEAKAELERKLSEKDEEI 1595
Cdd:PRK03918  711 KELE-KLEKALERVEELREKVKKYKALLKERALSKVGEI 748
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
984-1597 1.88e-12

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 72.75  E-value: 1.88e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   984 EHKVKNLTEEVEFLNEDISKLNRAAKVVQeahqqtlDDLHMEEEKLSSLSKANLKLEQQVDELEGALEQERKARMNCERE 1063
Cdd:TIGR04523   32 DTEEKQLEKKLKTIKNELKNKEKELKNLD-------KNLNKDEEKINNSNNKIKILEQQIKDLNDKLKKNKDKINKLNSD 104
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1064 LHKLEGNLKLNRESMENLESSQRHLAEELRKKELELSQMNSKVENEKGLVAQLQKTVKELQTQIKDLKEKLEAERTTRAK 1143
Cdd:TIGR04523  105 LSKINSEIKNDKEQKNKLEVELNKLEKQKKENKKNIDKFLTEIKKKEKELEKLNNKYNDLKKQKEELENELNLLEKEKLN 184
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1144 MERERADLTQDLADLNERL------EEVGGSSLAQLEITKKQ----ETKFQKLHRDMEEATLHFETTSASLK------KR 1207
Cdd:TIGR04523  185 IQKNIDKIKNKLLKLELLLsnlkkkIQKNKSLESQISELKKQnnqlKDNIEKKQQEINEKTTEISNTQTQLNqlkdeqNK 264
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1208 HADSLAELEGQVENLQQVKQKLEKDKSDLQLEVDDLLTRVEQMTRAK-----ANAEKLCTLYEERLHEATAKLDKVTQLA 1282
Cdd:TIGR04523  265 IKKQLSEKQKELEQNNKKIKELEKQLNQLKSEISDLNNQKEQDWNKElkselKNQEKKLEEIQNQISQNNKIISQLNEQI 344
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1283 NDLAAQKTKLWSESGEFLRRLEEKEALINQLSREKS-------NFTRQIEDLRGQLEKETKSQSALAHALQKAQRDCDLL 1355
Cdd:TIGR04523  345 SQLKKELTNSESENSEKQRELEEKQNEIEKLKKENQsykqeikNLESQINDLESKIQNQEKLNQQKDEQIKKLQQEKELL 424
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1356 REQYEEEQEVKAELHRTLSKVNAEMVQWRMKYENNVIQRTE-----------------DLEDAKKELAIRLQEAAEamgv 1418
Cdd:TIGR04523  425 EKEIERLKETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESletqlkvlsrsinkikqNLEQKQKELKSKEKELKK---- 500
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1419 ANARNASLERARHQLQLELGDALSDLGKVRSAAARLDQKqlqsgkaLADWKQKHEESQALLDASQ--KEVQALSTELLKL 1496
Cdd:TIGR04523  501 LNEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEKESK-------ISDLEDELNKDDFELKKENleKEIDEKNKEIEEL 573
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1497 KNTYEESIVGQETLRRENKNLQEEISNLTNQVREGTKNLTEMEKVKKLIEEEKTEVQVTLEETEGALERNESKILHFQLE 1576
Cdd:TIGR04523  574 KQTQKSLKKKQEEKQELIDQKEKEKKDLIKEIEEKEKKISSLEKELEKAKKENEKLSSIIKNIKSKKNKLKQEVKQIKET 653
                          650       660
                   ....*....|....*....|.
gi 767926067  1577 LLEAKAelerKLSEKDEEIEN 1597
Cdd:TIGR04523  654 IKEIRN----KWPEIIKKIKE 670
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
1220-1920 4.59e-12

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 71.54  E-value: 4.59e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1220 ENLQQVKQKLEKDKSDLQLEVDDLLTRVEQMTRAKANAEKLCTLYEERLHEATAKLDKVTQLaNDLAAQKTKLWSESGEF 1299
Cdd:TIGR00618  187 AKKKSLHGKAELLTLRSQLLTLCTPCMPDTYHERKQVLEKELKHLREALQQTQQSHAYLTQK-REAQEEQLKKQQLLKQL 265
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1300 LRRLEEKEALINQLS--REKSNFTRQIEDLrgqlekeTKSQSALAHALQKAQRDCDLLREQyeEEQEVKAELHRTLSKVN 1377
Cdd:TIGR00618  266 RARIEELRAQEAVLEetQERINRARKAAPL-------AAHIKAVTQIEQQAQRIHTELQSK--MRSRAKLLMKRAAHVKQ 336
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1378 AEMVQWRMKYENNVIQRTEDLEDAKKELAIRLQEAAEAMgvanarnaSLERARHQLQLELGdalSDLGKVRSAAARLDQK 1457
Cdd:TIGR00618  337 QSSIEEQRRLLQTLHSQEIHIRDAHEVATSIREISCQQH--------TLTQHIHTLQQQKT---TLTQKLQSLCKELDIL 405
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1458 QLQSGKALADWKQKHEESQALLDA-SQKEVQALSTELLKL--KNTYEESIVGQETLRRENKNLQEEISNLTNqVREGTKN 1534
Cdd:TIGR00618  406 QREQATIDTRTSAFRDLQGQLAHAkKQQELQQRYAELCAAaiTCTAQCEKLEKIHLQESAQSLKEREQQLQT-KEQIHLQ 484
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1535 LTEMEKVKKLIEEEKTEVQVTLEETEGALERNESKILHFQ------LELLEAKAELERKLSEKDEEIENFRRKQQCTIDS 1608
Cdd:TIGR00618  485 ETRKKAVVLARLLELQEEPCPLCGSCIHPNPARQDIDNPGpltrrmQRGEQTYAQLETSEEDVYHQLTSERKQRASLKEQ 564
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1609 LQSSLDSEAKSRIEVTRLKKKMEEDLNEMELQLSCANRQVSEATKSLGQLQIQIKDLQMQLDDSTQLNSDLKEQVAVAER 1688
Cdd:TIGR00618  565 MQEIQQSFSILTQCDNRSKEDIPNLQNITVRLQDLTEKLSEAEDMLACEQHALLRKLQPEQDLQDVRLHLQQCSQELALK 644
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1689 RNSLLQSELEDLRSLQEQTERGRRLSEEELLEATERInLFYTQN--TSLLSQKKKLEADVARMQKEAEEVVQECQNAEEK 1766
Cdd:TIGR00618  645 LTALHALQLTLTQERVREHALSIRVLPKELLASRQLA-LQKMQSekEQLTYWKEMLAQCQTLLRELETHIEEYDREFNEI 723
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1767 AKKAAIEAANLSEELKKKQDTIAHLERTRENMEQTITDLQKRLAEAEQMALMGSRKQ---IQKLESRVRELEGELEGEIR 1843
Cdd:TIGR00618  724 ENASSSLGSDLAAREDALNQSLKELMHQARTVLKARTEAHFNNNEEVTAALQTGAELshlAAEIQFFNRLREEDTHLLKT 803
                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767926067  1844 RSAEAQRGARRLErciKELTYQAEEDKKNLSRMQTQMDKLQLKVQNYKQQVEVAETQANQYLSKYKKQQHELNEVKE 1920
Cdd:TIGR00618  804 LEAEIGQEIPSDE---DILNLQCETLVQEEEQFLSRLEEKSATLGEITHQLLKYEECSKQLAQLTQEQAKIIQLSDK 877
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
1301-1919 5.11e-12

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 71.30  E-value: 5.11e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1301 RRLEEKealiNQLSREKSNFTRQ-IEDLRGQLEKETKSQSALAhalqkaqrdcDLLREQYEEEQEVKAELHRTLSKVNAE 1379
Cdd:pfam15921   92 RRLNES----NELHEKQKFYLRQsVIDLQTKLQEMQMERDAMA----------DIRRRESQSQEDLRNQLQNTVHELEAA 157
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1380 --MVQWRMKYENNVIQRTEDL----EDAKKELAIRLQEAAEAMG--------VANARNASLERARHQLQLELGDALSDL- 1444
Cdd:pfam15921  158 kcLKEDMLEDSNTQIEQLRKMmlshEGVLQEIRSILVDFEEASGkkiyehdsMSTMHFRSLGSAISKILRELDTEISYLk 237
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1445 GKVRSAAARLDQKQLQSGKALADWKQKHEES-QALLDASQKEVQALsTELLKLKNTYEESI-----VGQETLRRENKNLQ 1518
Cdd:pfam15921  238 GRIFPVEDQLEALKSESQNKIELLLQQHQDRiEQLISEHEVEITGL-TEKASSARSQANSIqsqleIIQEQARNQNSMYM 316
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1519 EEISNLTNQVREGTKNLTEMEKV--KKLIEEEKTEVQVTLEETEGALERN----ESKILHFQLE-LLEAKAELERKLS-- 1589
Cdd:pfam15921  317 RQLSDLESTVSQLRSELREAKRMyeDKIEELEKQLVLANSELTEARTERDqfsqESGNLDDQLQkLLADLHKREKELSle 396
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1590 -EKDEEIENFRRKQQCTIDSLQSSLDSEaksRIEVTRLKKKMEEDLNEMELQLSCANRQVSEATKSLGQlqiqIKDLQMQ 1668
Cdd:pfam15921  397 kEQNKRLWDRDTGNSITIDHLRRELDDR---NMEVQRLEALLKAMKSECQGQMERQMAAIQGKNESLEK----VSSLTAQ 469
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1669 LDDSTQLNSDLKEQVAVaeRRNSLLQSE--LEDLRSLQEQTERGRRLSEEELLEATERINLFYTQntslLSQKKKLEADV 1746
Cdd:pfam15921  470 LESTKEMLRKVVEELTA--KKMTLESSErtVSDLTASLQEKERAIEATNAEITKLRSRVDLKLQE----LQHLKNEGDHL 543
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1747 ARMQKEAEEVVQECQNAEEKAKKAAIEAANLSEELKKKQDTIAHLERTRENMEQTITDlqkRLAEAEQMALMGSRK--QI 1824
Cdd:pfam15921  544 RNVQTECEALKLQMAEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEIND---RRLELQEFKILKDKKdaKI 620
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1825 QKLESRVRELEGELEGEIRRSAEAQRGARRLERCIKELTYQAEEDKKNLSRMQTQMDKLQlkvQNYKQQVEVAETQANQY 1904
Cdd:pfam15921  621 RELEARVSDLELEKVKLVNAGSERLRAVKDIKQERDQLLNEVKTSRNELNSLSEDYEVLK---RNFRNKSEEMETTTNKL 697
                          650
                   ....*....|....*
gi 767926067  1905 LSKYKKQQHELNEVK 1919
Cdd:pfam15921  698 KMQLKSAQSELEQTR 712
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
870-1292 7.23e-12

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 70.82  E-value: 7.23e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   870 QLQKALEKsefQREELKAKQVSLTQEKNDLILQLQAEQETLANVEEQCEWLIKSKIQLEARVKELSERVEEEEEINSELT 949
Cdd:TIGR04523  211 QKNKSLES---QISELKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQNKIKKQLSEKQKELEQNNKKIKELE 287
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   950 ARGRKLEDECFELKKE-----IDDLETMLVKSEKEKRTTEHKVKNLTEEVEFLNEDISKLNRAAKVVQEAHQQTLDDLHM 1024
Cdd:TIGR04523  288 KQLNQLKSEISDLNNQkeqdwNKELKSELKNQEKKLEEIQNQISQNNKIISQLNEQISQLKKELTNSESENSEKQRELEE 367
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1025 EEEKLSSLSKAN-------LKLEQQVDELEGALEQERKARMNCERELHKLEGNLKLNRESMENLESSQRHLAEELRKKEL 1097
Cdd:TIGR04523  368 KQNEIEKLKKENqsykqeiKNLESQINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSEIKDLTN 447
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1098 ELSQMNSKVENEKGLVAQLQKTVKELQTQIKDLKEKLEAERTTRAKMERERADLTQDLADLNERLEEVGG------SSLA 1171
Cdd:TIGR04523  448 QDSVKELIIKNLDNTRESLETQLKVLSRSINKIKQNLEQKQKELKSKEKELKKLNEEKKELEEKVKDLTKkisslkEKIE 527
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1172 QLEITKKQ-ETKFQKLHRDMEEatLHFETTSASLKKrhadSLAELEGQVENLQQVKQKLEKDKSDLQLEVDDLLTRVEQM 1250
Cdd:TIGR04523  528 KLESEKKEkESKISDLEDELNK--DDFELKKENLEK----EIDEKNKEIEELKQTQKSLKKKQEEKQELIDQKEKEKKDL 601
                          410       420       430       440
                   ....*....|....*....|....*....|....*....|..
gi 767926067  1251 TRAKANAEKLCTLYEERLHEATAKLDKVTQLANDLAAQKTKL 1292
Cdd:TIGR04523  602 IKEIEEKEKKISSLEKELEKAKKENEKLSSIIKNIKSKKNKL 643
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
1674-1946 1.13e-11

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 70.35  E-value: 1.13e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1674 QLNSdLKEQVAVAER-----------RNSLLQSELEDLRSLQEQTERGRRLSEEELLEATERINLFYTQNTSLLSQKKKL 1742
Cdd:COG1196   201 QLEP-LERQAEKAERyrelkeelkelEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEEL 279
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1743 EADVARMQKEAEEVVQECQNAEEKAKKAAIEAANLSEELKKKQDTIAHLERTRENMEQTITDLQKRLAEAEQmALMGSRK 1822
Cdd:COG1196   280 ELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEE-ELEEAEA 358
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1823 QIQKLESRVRELEGELEGEIRRSAEAQRGARRLERCIKELTYQAEEDKKNLSRMQTQMDKLQLKVQNYKQQVEVAETQAN 1902
Cdd:COG1196   359 ELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEE 438
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 767926067 1903 QYLSKYKKQQHELNEVKERAEVAESQVNKLKIKAREFGKKVQEE 1946
Cdd:COG1196   439 EEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAEL 482
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1075-1640 2.95e-11

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 68.79  E-value: 2.95e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1075 RESMENLESSQRHLAEELRKKELeLSQMNSKVENEKGLVAQLQK--------TVKELQTQIKDLKEKLEAERTTRAKMER 1146
Cdd:COG4913   231 VEHFDDLERAHEALEDAREQIEL-LEPIRELAERYAAARERLAEleylraalRLWFAQRRLELLEAELEELRAELARLEA 309
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1147 ERADLTQDLADLNERLEEV-------GGSSLAQLE--------ITKKQETKFQKLHRDMEEATLHFETTS---ASLKKRH 1208
Cdd:COG4913   310 ELERLEARLDALREELDELeaqirgnGGDRLEQLEreierlerELEERERRRARLEALLAALGLPLPASAeefAALRAEA 389
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1209 ADSLAELEGQVENLQQVKQKLEKDKSDLQLEVDDLLTRVEQMTRAKANaeklctlYEERLHEATAKLDKVTQLAND---- 1284
Cdd:COG4913   390 AALLEALEEELEALEEALAEAEAALRDLRRELRELEAEIASLERRKSN-------IPARLLALRDALAEALGLDEAelpf 462
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1285 ---------------------LAAQKTKL------WSESGEFLRRLEEKEAL-INQLSREKSNFTRQIEDLRGQLEK-ET 1335
Cdd:COG4913   463 vgelievrpeeerwrgaiervLGGFALTLlvppehYAAALRWVNRLHLRGRLvYERVRTGLPDPERPRLDPDSLAGKlDF 542
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1336 KSQSALAHALQKAQRDCDLLREQYEEEqevkaeLHRT--------LSKVNAEMVQ---WRMKYENNVIQRteDLEDAKKE 1404
Cdd:COG4913   543 KPHPFRAWLEAELGRRFDYVCVDSPEE------LRRHpraitragQVKGNGTRHEkddRRRIRSRYVLGF--DNRAKLAA 614
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1405 LAIRLQEAAEAMGVANARNASLERARHQLQlELGDALSDLGKVRSaaARLDQKQLQsgKALADWKQKHEEsqalLDASQK 1484
Cdd:COG4913   615 LEAELAELEEELAEAEERLEALEAELDALQ-ERREALQRLAEYSW--DEIDVASAE--REIAELEAELER----LDASSD 685
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1485 EVQALSTELLKLKNTYEESIVGQETLRRENKNLQEEISNLTNQVREGTKNLTEMEKVKKLIEEEKTEVQVtLEETEGALE 1564
Cdd:COG4913   686 DLAALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLELRALLEERF-AAALGDAVE 764
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1565 RNESKILHFQLELLEAKAE-LERKLSEKdeeIENFRRKQQCTIDSLQSSLDSEAK-----SRIEVTRL---KKKMEEDLN 1635
Cdd:COG4913   765 RELRENLEERIDALRARLNrAEEELERA---MRAFNREWPAETADLDADLESLPEylallDRLEEDGLpeyEERFKELLN 841

                  ....*
gi 767926067 1636 EMELQ 1640
Cdd:COG4913   842 ENSIE 846
Myosin_N pfam02736
Myosin N-terminal SH3-like domain; This domain has an SH3-like fold. It is found at the ...
49-94 3.43e-11

Myosin N-terminal SH3-like domain; This domain has an SH3-like fold. It is found at the N-terminus of many but not all myosins. The function of this domain is unknown.


Pssm-ID: 460670  Cd Length: 45  Bit Score: 59.75  E-value: 3.43e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 767926067    49 DGKKKCWIPDGENAYIEAEVKgSEDDGTVIVETADGESLSIKEDKI 94
Cdd:pfam02736    1 DAKKLVWVPDPKEGFVKGEIK-EEEGDKVTVETEDGKTVTVKKDDV 45
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
911-1551 4.67e-11

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 68.17  E-value: 4.67e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  911 ANVEEQCEWLIKSKIQLEARVKELSERVEEEEEINSELTARGRKLEdecfELKKEIDDLETMLVKSEKEKRTTEHKVKNL 990
Cdd:PRK03918  189 ENIEELIKEKEKELEEVLREINEISSELPELREELEKLEKEVKELE----ELKEEIEELEKELESLEGSKRKLEEKIREL 264
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  991 TEEVEFLNEDISKLNRAAKVVQEahqqtLDDLHMEEEKLSSLSKANLKLEQQVDELEGALEQERKarmNCERELHKLEGN 1070
Cdd:PRK03918  265 EERIEELKKEIEELEEKVKELKE-----LKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEIN---GIEERIKELEEK 336
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1071 LKLNRESMENLESSQRHLaEELRKKELELSQMNSKVENEKGLVAQLQ-KTVKELQTQIKDLKEKLEAERTTRAKMERERA 1149
Cdd:PRK03918  337 EERLEELKKKLKELEKRL-EELEERHELYEEAKAKKEELERLKKRLTgLTPEKLEKELEELEKAKEEIEEEISKITARIG 415
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1150 DLTQDLADLNERLEEVggsslaqleitKKQETKFQKLHRDMEeatlhfETTSASLKKRHADSLAELEGQVENLQQVKQKL 1229
Cdd:PRK03918  416 ELKKEIKELKKAIEEL-----------KKAKGKCPVCGRELT------EEHRKELLEEYTAELKRIEKELKEIEEKERKL 478
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1230 EKDKSdlqlEVDDLLTRVEQMTRAKANAEKLCTLYEERLHEATAKLDKVTQLANDLAAQKTKLWSESGEFLRRLEEKEAL 1309
Cdd:PRK03918  479 RKELR----ELEKVLKKESELIKLKELAEQLKELEEKLKKYNLEELEKKAEEYEKLKEKLIKLKGEIKSLKKELEKLEEL 554
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1310 INQLsREKSNFTRQIEDLRGQLEKEtksqsalahalqkaqrdcdLLREQYEEEQEVKAELhRTLSKVNAEMVQWRmkyen 1389
Cdd:PRK03918  555 KKKL-AELEKKLDELEEELAELLKE-------------------LEELGFESVEELEERL-KELEPFYNEYLELK----- 608
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1390 NVIQRTEDLEDAKKELAIRLQEAAEAMGVANARnasLERARHQLQlELGDALSDlgkvrSAAARLDQKQLQSGKALADWK 1469
Cdd:PRK03918  609 DAEKELEREEKELKKLEEELDKAFEELAETEKR---LEELRKELE-ELEKKYSE-----EEYEELREEYLELSRELAGLR 679
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1470 QKHEESQALLDASQKEVQALSTELLKLKNtYEESIVGQETLRRENKNLQEEISNLTNQVREGTknLTEMEKVKKLIEEEK 1549
Cdd:PRK03918  680 AELEELEKRREEIKKTLEKLKEELEEREK-AKKELEKLEKALERVEELREKVKKYKALLKERA--LSKVGEIASEIFEEL 756

                  ..
gi 767926067 1550 TE 1551
Cdd:PRK03918  757 TE 758
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
1021-1761 6.11e-11

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 68.07  E-value: 6.11e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1021 DLHMEEEKLSSLSKANLKLEQQVDELEGALEQERKArmNCERELHKLEGNLKLNRESMENLeSSQRHLAEELRKKELELS 1100
Cdd:TIGR00618  187 AKKKSLHGKAELLTLRSQLLTLCTPCMPDTYHERKQ--VLEKELKHLREALQQTQQSHAYL-TQKREAQEEQLKKQQLLK 263
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1101 QMNSKVENEKGLVAQLQKTVKELQTQIKDLKEKLEAERTTrakmereradltqdladlnerleevggsslaqlEITKKQE 1180
Cdd:TIGR00618  264 QLRARIEELRAQEAVLEETQERINRARKAAPLAAHIKAVT---------------------------------QIEQQAQ 310
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1181 TKFQKLHRDMEEATLHFETTSASLKKRhadslAELEGQVENLQQVKQKLEKdksdLQLEVDDLLTRVEQMTRAKANaekl 1260
Cdd:TIGR00618  311 RIHTELQSKMRSRAKLLMKRAAHVKQQ-----SSIEEQRRLLQTLHSQEIH----IRDAHEVATSIREISCQQHTL---- 377
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1261 ctlyEERLHEATAKLDKVTQLANDLAAQKTKLWSESGEFLRRLEEKEALINQLSREKSNFTRQIEDLRGQ---LEKETKS 1337
Cdd:TIGR00618  378 ----TQHIHTLQQQKTTLTQKLQSLCKELDILQREQATIDTRTSAFRDLQGQLAHAKKQQELQQRYAELCaaaITCTAQC 453
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1338 QSALAHALQKAQRDcdlLREQYEEEQEVKaelhrTLSKVNAEMVQWRMKYENNVIQRTEDLEDAKKELAIRLQEAAEAmG 1417
Cdd:TIGR00618  454 EKLEKIHLQESAQS---LKEREQQLQTKE-----QIHLQETRKKAVVLARLLELQEEPCPLCGSCIHPNPARQDIDNP-G 524
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1418 VANARNASLERARHQLQLELGDALSDLGKVRSAAARLDQKQLQSGKALADWKQKHEESQALLDASQKEVQALSTELLKLK 1497
Cdd:TIGR00618  525 PLTRRMQRGEQTYAQLETSEEDVYHQLTSERKQRASLKEQMQEIQQSFSILTQCDNRSKEDIPNLQNITVRLQDLTEKLS 604
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1498 ntyEESIVGQETLRRENKNLQEEISNLTNQVREGTKnltEMEKVKKLIEEEKTEVQVTLEETEGALERneskILHFQLEL 1577
Cdd:TIGR00618  605 ---EAEDMLACEQHALLRKLQPEQDLQDVRLHLQQC---SQELALKLTALHALQLTLTQERVREHALS----IRVLPKEL 674
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1578 LEAKAELERKLSEKDEEIENFRRKQQCTIDSLQSSLDSEAKSRIEVTRLKKKMEEDLNEMELQLSCANRQVSEATKSLG- 1656
Cdd:TIGR00618  675 LASRQLALQKMQSEKEQLTYWKEMLAQCQTLLRELETHIEEYDREFNEIENASSSLGSDLAAREDALNQSLKELMHQARt 754
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1657 QLQIQIKDLQMQLDDST---QLNSDLKEQVAVAERRNSLLQSELEDLRSLQEQTERGRRLSEEELLEATERINLFYTQNT 1733
Cdd:TIGR00618  755 VLKARTEAHFNNNEEVTaalQTGAELSHLAAEIQFFNRLREEDTHLLKTLEAEIGQEIPSDEDILNLQCETLVQEEEQFL 834
                          730       740
                   ....*....|....*....|....*...
gi 767926067  1734 SLLSQKKKLEADVARMQKEAEEVVQECQ 1761
Cdd:TIGR00618  835 SRLEEKSATLGEITHQLLKYEECSKQLA 862
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
946-1257 6.71e-11

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 67.79  E-value: 6.71e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   946 SELTARGRKLEDECFELKKEIDDLETMLVKSEKEKRTTEHKVKNLTEEVEFLNEDISKLNRAAKVVQEAHQQTLDDLHME 1025
Cdd:TIGR02169  691 SSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEARIEEL 770
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1026 EEKLSSLSKANLKLE-----QQVDELEGALEQERKARMNCERELHKLEGNLKLNRESMENLESSQRHLAEELRKKELELS 1100
Cdd:TIGR02169  771 EEDLHKLEEALNDLEarlshSRIPEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIK 850
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1101 QMNSKVENEKGLVAQLQKTVKELQTQIKDLKEKLEAERTTRAKMERERADLTQDLADLN---ERLEEVGGSSLAQLEITK 1177
Cdd:TIGR02169  851 SIEKEIENLNGKKEELEEELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEELEaqiEKKRKRLSELKAKLEALE 930
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1178 KQETKFQKLHRDMEE---ATLHFETTSASLKKRHADSLA----------ELEGQVENLQQVKQKLEKdksdLQLEVDDLL 1244
Cdd:TIGR02169  931 EELSEIEDPKGEDEEipeEELSLEDVQAELQRVEEEIRAlepvnmlaiqEYEEVLKRLDELKEKRAK----LEEERKAIL 1006
                          330
                   ....*....|...
gi 767926067  1245 TRVEQMTRAKANA 1257
Cdd:TIGR02169 1007 ERIEEYEKKKREV 1019
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
1618-1933 6.79e-11

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 67.65  E-value: 6.79e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1618 KSRIEVTRLK-KKMEEDLN-------EMELQLSCANRQVSEATKSLgQLQIQIKDLQMQLddstQLNSD--LKEQVAVAE 1687
Cdd:COG1196   171 KERKEEAERKlEATEENLErledilgELERQLEPLERQAEKAERYR-ELKEELKELEAEL----LLLKLreLEAELEELE 245
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1688 RRNSLLQSELEDLRSLQEQTERGRRLSEEELLEATERINLFYTQNTSLLSQKKKLEADVARMQKEAEEVVQECQNAEEKA 1767
Cdd:COG1196   246 AELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEEL 325
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1768 KKAAIEAANLSEELKKKQDTIAHLERTRENMEQTITDLQKRLAEAEQMALMGSRKQIQKLESRVRELEGELEGEIRRSAE 1847
Cdd:COG1196   326 AELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEEL 405
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1848 AQRGARRLERcIKELTYQAEEDKKNLSRMQTQMDKLQLKVQNYKQQVEVAETQANQYLSKYKKQQHELNEVKERAEVAES 1927
Cdd:COG1196   406 EEAEEALLER-LERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLE 484

                  ....*.
gi 767926067 1928 QVNKLK 1933
Cdd:COG1196   485 ELAEAA 490
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
864-1135 1.60e-10

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 66.20  E-value: 1.60e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   864 LKEECAQLQKALEKSEFQREELKAKQVSLTQEKNDLILQLQAEQETLANVEEQCEWLIKSKIQLEARVKELSERVEEEEE 943
Cdd:TIGR04523  361 KQRELEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIERLKETIIKNNS 440
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   944 INSELTARGRKLEDECFELKKEIDDLETMLVKSEKEKRTTEHKVKNLTEEVEFLNEDISKLNRAAKVVQEAHQQTLDDLH 1023
Cdd:TIGR04523  441 EIKDLTNQDSVKELIIKNLDNTRESLETQLKVLSRSINKIKQNLEQKQKELKSKEKELKKLNEEKKELEEKVKDLTKKIS 520
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1024 MEEEKLSSLSKANLKLEQQVDELEGALEQ--ERKARMNCERELHKLEGNLKLNRESMENLESSQRHLAEELRKKELELSQ 1101
Cdd:TIGR04523  521 SLKEKIEKLESEKKEKESKISDLEDELNKddFELKKENLEKEIDEKNKEIEELKQTQKSLKKKQEEKQELIDQKEKEKKD 600
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|.
gi 767926067  1102 MNSKVENEKGLVAQLQKTV-------KELQTQIKDLKEKLE 1135
Cdd:TIGR04523  601 LIKEIEEKEKKISSLEKELekakkenEKLSSIIKNIKSKKN 641
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
1510-1945 2.64e-10

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 65.43  E-value: 2.64e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1510 LRRENKNLQEEISNLTNQVREGTKNLTEMEKVKKLIEEEKTEVQVTLEETEGALERNESKILHFQLELLEAKAELE---- 1585
Cdd:TIGR04523  223 LKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQNKIKKQLSEKQKELEQNNKKIKELEKQLNQLKSEISdlnn 302
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1586 --------------RKLSEKDEEIENFRRKQQCTIDSLQSSLDSEAKSRIEVTRLKKKMEEDLNEMELQLSCANRQVSEA 1651
Cdd:TIGR04523  303 qkeqdwnkelkselKNQEKKLEEIQNQISQNNKIISQLNEQISQLKKELTNSESENSEKQRELEEKQNEIEKLKKENQSY 382
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1652 TKSLGQLQIQIKDLQMQLDDSTQLNSDLKEQVAVAERRNSLLQSELEDLRSLQEQTERGRRLSEEELLEATERINLFYTQ 1731
Cdd:TIGR04523  383 KQEIKNLESQINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVKELIIKNLDNT 462
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1732 NTSLLSQKKKLEADVARMQKEAEEVVQECQNAEEKAKKAAIEAANLSEELKKKQDTIAHLERTRENMEQTITDLQKRLAE 1811
Cdd:TIGR04523  463 RESLETQLKVLSRSINKIKQNLEQKQKELKSKEKELKKLNEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEKESKISD 542
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1812 AEQMAL-MGSRKQIQKLESRVRelegELEGEIRRSAEAQRGARRLERCIKELTYQAEEDKKNLSRmqtQMDKLQLKVQNY 1890
Cdd:TIGR04523  543 LEDELNkDDFELKKENLEKEID----EKNKEIEELKQTQKSLKKKQEEKQELIDQKEKEKKDLIK---EIEEKEKKISSL 615
                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 767926067  1891 KQQVEVAETQANQYLSKYKKQQHELNEVKERAEVAESQVNKLKIKAREFGKKVQE 1945
Cdd:TIGR04523  616 EKELEKAKKENEKLSSIIKNIKSKKNKLKQEVKQIKETIKEIRNKWPEIIKKIKE 670
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1579-1820 4.66e-10

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 63.63  E-value: 4.66e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1579 EAKAELERKLSEKDEEIENfrrkqqctidsLQSSLDSEAKSRIEVTRLKKKMEEDLNEMELQLSCANRQVSEATKSLGQL 1658
Cdd:COG4942    20 DAAAEAEAELEQLQQEIAE-----------LEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAEL 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1659 QIQIKDLQMQLDdstQLNSDLKEQVAVAERRNSllQSELEDLRSLQE--QTERGRRLSEEELLEATERINLFYTQNTSLL 1736
Cdd:COG4942    89 EKEIAELRAELE---AQKEELAELLRALYRLGR--QPPLALLLSPEDflDAVRRLQYLKYLAPARREQAEELRADLAELA 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1737 SQKKKLEADVARMQKEAEEVVQECQNAEEKAKKAAIEAANLSEELKKKQDTIAHLERTRENMEQTITDLQKRLAEAEQMA 1816
Cdd:COG4942   164 ALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERT 243

                  ....
gi 767926067 1817 LMGS 1820
Cdd:COG4942   244 PAAG 247
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
1456-1933 4.95e-10

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 65.14  E-value: 4.95e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1456 QKQLQSGKALADwKQKHEESQALLDAsQKEVQALSTELLKLKNTYEESIVGQETLRRENKNLQEEISNLTNQVREGTKNL 1535
Cdd:pfam15921   91 QRRLNESNELHE-KQKFYLRQSVIDL-QTKLQEMQMERDAMADIRRRESQSQEDLRNQLQNTVHELEAAKCLKEDMLEDS 168
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1536 -TEMEKVKKL------IEEEKTEVQVTLEETEGA--LERNESKILHFQlellEAKAELERKLSEKDEEIENFRRKQQCTI 1606
Cdd:pfam15921  169 nTQIEQLRKMmlshegVLQEIRSILVDFEEASGKkiYEHDSMSTMHFR----SLGSAISKILRELDTEISYLKGRIFPVE 244
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1607 DSLQSsLDSEAKSRIEV--TRLKKKMEEDLNEMELQLSCANRQVSEATKSLGQLQIQIKDLQMQLDDStqlNSDLKEQVA 1684
Cdd:pfam15921  245 DQLEA-LKSESQNKIELllQQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQLEIIQEQARNQ---NSMYMRQLS 320
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1685 VAERRNSLLQSELEDLRSLQE----QTERGRRLSEEELLEATERINLFYTQNTSLLSQKKKLEADVARMQKEAEevVQEC 1760
Cdd:pfam15921  321 DLESTVSQLRSELREAKRMYEdkieELEKQLVLANSELTEARTERDQFSQESGNLDDQLQKLLADLHKREKELS--LEKE 398
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1761 QNAeekakkaaieaaNLSEELKKKQDTIAHLERTRE--NMEqtitdlqkrlaeaeqmalmgsrkqIQKLESRVRELEGEL 1838
Cdd:pfam15921  399 QNK------------RLWDRDTGNSITIDHLRRELDdrNME------------------------VQRLEALLKAMKSEC 442
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1839 EGEIRRSAEAQRGARRLERCIKELTYQAEEDKKNLSRMQTQMDKLQLKVQNYKQQVEVAETQANQYLSKYKKQQHELNEV 1918
Cdd:pfam15921  443 QGQMERQMAAIQGKNESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTLESSERTVSDLTASLQEKERAIEATNAEITKL 522
                          490
                   ....*....|....*
gi 767926067  1919 KERAEVAESQVNKLK 1933
Cdd:pfam15921  523 RSRVDLKLQELQHLK 537
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
883-1569 6.56e-10

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 64.47  E-value: 6.56e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   883 EELKAKQVSLTQEKNDLILQLQAEQETLANVEEQcewlIKSKIQLEARVKELSER-VEEEEEINSELTARGRKLEDECFE 961
Cdd:pfam12128  216 SRLNRQQVEHWIRDIQAIAGIMKIRPEFTKLQQE----FNTLESAELRLSHLHFGyKSDETLIASRQEERQETSAELNQL 291
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   962 LKKEIDDLETMLVKSEKEKRTTEHKVKNLTEEVEFLNEDISKLNRAAKVVQEAHQQTLDDLHMEEEKLSSLSKANLKLEQ 1041
Cdd:pfam12128  292 LRTLDDQWKEKRDELNGELSAADAAVAKDRSELEALEDQHGAFLDADIETAAADQEQLPSWQSELENLEERLKALTGKHQ 371
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1042 QVDELEGALEQERKARmnCERELHKLEGNLKLNRES-----------MENLESSQRH-LAEELRKKELELSQMNSKVENE 1109
Cdd:pfam12128  372 DVTAKYNRRRSKIKEQ--NNRDIAGIKDKLAKIREArdrqlavaeddLQALESELREqLEAGKLEFNEEEYRLKSRLGEL 449
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1110 KGLVAQLQKTvKELQTQIKDLKEKLEAERTTRAKMERERADLTQDLADLNERLEEvGGSSLAQLEI-TKKQETKFQKLHR 1188
Cdd:pfam12128  450 KLRLNQATAT-PELLLQLENFDERIERAREEQEAANAEVERLQSELRQARKRRDQ-ASEALRQASRrLEERQSALDELEL 527
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1189 DMEEAT---LHFETTSASLKKRHADSLAELE----------------GQVENLQQVKQKLEK-DKSDLQLEVDDLLTRVE 1248
Cdd:pfam12128  528 QLFPQAgtlLHFLRKEAPDWEQSIGKVISPEllhrtdldpevwdgsvGGELNLYGVKLDLKRiDVPEWAASEEELRERLD 607
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1249 QMTRAKANAEKLCTLYEERLHEATAKLDKVtQLANDLAAQKTKlwsESGEFLRRL-EEKEALINQLSREKSNFTRQIEDL 1327
Cdd:pfam12128  608 KAEEALQSAREKQAAAEEQLVQANGELEKA-SREETFARTALK---NARLDLRRLfDEKQSEKDKKNKALAERKDSANER 683
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1328 RGQLEKETKsQSALAHALQKAQRDcDLLREQYEEEQEVKAELHRTLSKVNAEMVQWRMKYENNVIQRTEDLE-DAKKELA 1406
Cdd:pfam12128  684 LNSLEAQLK-QLDKKHQAWLEEQK-EQKREARTEKQAYWQVVEGALDAQLALLKAAIAARRSGAKAELKALEtWYKRDLA 761
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1407 irlqeaaeAMGVANARNASLERARHqlqlELGDALSDLGKVRSAAARLDQKQLQSgkaladWKQKHEESQALLDASQKEV 1486
Cdd:pfam12128  762 --------SLGVDPDVIAKLKREIR----TLERKIERIAVRRQEVLRYFDWYQET------WLQRRPRLATQLSNIERAI 823
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1487 QALSTELLKLkntyeesivgQETLRRENKNLQEEISNLTNQVREGTKNLT----EMEKVKKLIEEEKTE-VQVTLEETEG 1561
Cdd:pfam12128  824 SELQQQLARL----------IADTKLRRAKLEMERKASEKQQVRLSENLRglrcEMSKLATLKEDANSEqAQGSIGERLA 893

                   ....*...
gi 767926067  1562 ALERNESK 1569
Cdd:pfam12128  894 QLEDLKLK 901
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1026-1502 7.65e-10

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 64.02  E-value: 7.65e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1026 EEKLSSLSKANLKLEQQVDELEGALEQERKARMNCERELHKLEGNLKLNRESMENLESSQRHLAEELRKKELELSQMNSK 1105
Cdd:COG4717    52 EKEADELFKPQGRKPELNLKELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQLLPLY 131
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1106 VENEkglvaQLQKTVKELQTQIKDLKEKLEAERTTRAKMERERADLTQDLADLNERLEEVGGSSLAQLEITKKQETKFQK 1185
Cdd:COG4717   132 QELE-----ALEAELAELPERLEELEERLEELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQ 206
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1186 LHRDMEEAtlhfettsaslkkrhadsLAELEGQVENLQQVKQKLEKDKSDLQLEvdDLLTRVEQMTRAKANAEKLCTLYE 1265
Cdd:COG4717   207 RLAELEEE------------------LEEAQEELEELEEELEQLENELEAAALE--ERLKEARLLLLIAAALLALLGLGG 266
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1266 ERLHEATAKLDKVTQLANDLAAQKTKLWSESGEFLRRLEEKEALINQLSREKSNFTRQIEDLRGQLEKETKSQSALAHAL 1345
Cdd:COG4717   267 SLLSLILTIAGVLFLVLGLLALLFLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRI 346
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1346 QKAQRDCDLLREQYEE--EQEVKAELHRTLSKVNAEMV-QWRMKYENnvIQRTEDLEDAKKELAIRLQEAAEAMGVANAR 1422
Cdd:COG4717   347 EELQELLREAEELEEElqLEELEQEIAALLAEAGVEDEeELRAALEQ--AEEYQELKEELEELEEQLEELLGELEELLEA 424
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1423 N--ASLERARHQLQLELGDALSDLGKVRSAAARLDQ--KQLQSGKALADWKQKHEESQALLDASQKEVQALSTELLKLKN 1498
Cdd:COG4717   425 LdeEELEEELEELEEELEELEEELEELREELAELEAelEQLEEDGELAELLQELEELKAELRELAEEWAALKLALELLEE 504

                  ....
gi 767926067 1499 TYEE 1502
Cdd:COG4717   505 AREE 508
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
855-1266 8.33e-10

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 64.29  E-value: 8.33e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  855 SEVGEEVAGLKEECAQLQKALEKSEFQREELKAKQVSLTQEKNDLILQLQAeqetlanVEEQCEWLIKSKIQLEARVKel 934
Cdd:PRK02224  289 EELEEERDDLLAEAGLDDADAEAVEARREELEDRDEELRDRLEECRVAAQA-------HNEEAESLREDADDLEERAE-- 359
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  935 sERVEEEEEINSELTARGRKLED---ECFELKKEIDDLETMLVKSEKEKRTTEHKVKNLTEEVEFLNEDI----SKLNRA 1007
Cdd:PRK02224  360 -ELREEAAELESELEEAREAVEDrreEIEELEEEIEELRERFGDAPVDLGNAEDFLEELREERDELREREaeleATLRTA 438
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1008 AKVVQEA--------------------HQQTLDDlhmEEEKLSSLSKANLKLEQQVDELEGALEQERKARmNCERELHKL 1067
Cdd:PRK02224  439 RERVEEAealleagkcpecgqpvegspHVETIEE---DRERVEELEAELEDLEEEVEEVEERLERAEDLV-EAEDRIERL 514
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1068 EGNLKLNRESMENLESS---QRHLAEELRKKELEL-SQMNSKVE--NEKGLVAQ-LQKTVKELQTQIKDLKEKLEAERTT 1140
Cdd:PRK02224  515 EERREDLEELIAERRETieeKRERAEELRERAAELeAEAEEKREaaAEAEEEAEeAREEVAELNSKLAELKERIESLERI 594
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1141 RAKMErERADLTQDLADLNERLEEVGGSSLAQLEITKKQETKFQKLHRDMEEATLhfeTTSASLKKRHADSLAELEGQVE 1220
Cdd:PRK02224  595 RTLLA-AIADAEDEIERLREKREALAELNDERRERLAEKRERKRELEAEFDEARI---EEAREDKERAEEYLEQVEEKLD 670
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*.
gi 767926067 1221 NLQQVKQKLEKDKSDLQLEVDDLLTRVEQMTRAKANAEKLCTLYEE 1266
Cdd:PRK02224  671 ELREERDDLQAEIGAVENELEELEELRERREALENRVEALEALYDE 716
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
1112-1504 8.35e-10

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 64.20  E-value: 8.35e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1112 LVAQLQKTVKELQTQIKDLKEKLEAERTTRAKMERERADLTQDLADLNERLEEVGGSSLAQLEITKKQEtkfqklhrDME 1191
Cdd:COG3096   286 RALELRRELFGARRQLAEEQYRLVEMARELEELSARESDLEQDYQAASDHLNLVQTALRQQEKIERYQE--------DLE 357
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1192 EATLHFETTSASLKKRHaDSLAELEGQVENLQQVKQKLEKDKSDLQLEVDDLLTRV---EQMTRAKANAEKLCTL----- 1263
Cdd:COG3096   358 ELTERLEEQEEVVEEAA-EQLAEAEARLEAAEEEVDSLKSQLADYQQALDVQQTRAiqyQQAVQALEKARALCGLpdltp 436
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1264 --YEERLHEATAKLDKVTQLANDLaAQKTKLWSES-GEFLRRLEEKEALINQLSREKSNFTRQiedlrgQLEKETKSQSA 1340
Cdd:COG3096   437 enAEDYLAAFRAKEQQATEEVLEL-EQKLSVADAArRQFEKAYELVCKIAGEVERSQAWQTAR------ELLRRYRSQQA 509
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1341 LAHALQKAQRDCDLLREQYEEEQEVKAELHRtLSKvnaemvqwRMKYEnnvIQRTEDLEDAKKELAIRLQEAAEAMGVAN 1420
Cdd:COG3096   510 LAQRLQQLRAQLAELEQRLRQQQNAERLLEE-FCQ--------RIGQQ---LDAAEELEELLAELEAQLEELEEQAAEAV 577
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1421 ARNASLERARHQLQLELGdALSDLGKV-RSAAARLDQKQLQSGKALADWKQKHEESQALLDAsQKEVQALSTELLKLKNT 1499
Cdd:COG3096   578 EQRSELRQQLEQLRARIK-ELAARAPAwLAAQDALERLREQSGEALADSQEVTAAMQQLLER-EREATVERDELAARKQA 655

                  ....*
gi 767926067 1500 YEESI 1504
Cdd:COG3096   656 LESQI 660
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
853-1259 1.16e-09

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 63.50  E-value: 1.16e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   853 KSSEVGEEVAGLKEECAQLQKALEKSEFQREELKAKQVSLTQ------EKNDLILQLQAEQETLANVEEQcEWLIKSKIQ 926
Cdd:TIGR04523  237 KQQEINEKTTEISNTQTQLNQLKDEQNKIKKQLSEKQKELEQnnkkikELEKQLNQLKSEISDLNNQKEQ-DWNKELKSE 315
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   927 LEARVKELSERVEEEEEINSELTargrKLEDECFELKKEIDDLETMLVKSEKEKRTTEHKVKNLTEEVEFLNEDISKLNR 1006
Cdd:TIGR04523  316 LKNQEKKLEEIQNQISQNNKIIS----QLNEQISQLKKELTNSESENSEKQRELEEKQNEIEKLKKENQSYKQEIKNLES 391
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1007 AAKVVQEAHQQTLDDLHMEEEKLSSLSKANLKLEQQVDELEGALEQERKARMNCERELHKLE---GNLKLNRESMEN--- 1080
Cdd:TIGR04523  392 QINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVKEliiKNLDNTRESLETqlk 471
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1081 -LESSQRHLAEELRKKELELSQMNSKVENEKGLVAQLQKTVKELQTQIKDLKEKLEAERTTRAKMERERADLTQDLADLN 1159
Cdd:TIGR04523  472 vLSRSINKIKQNLEQKQKELKSKEKELKKLNEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEKESKISDLEDELNKDD 551
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1160 ERLeevggsslaqleitKKQETKFQKLHRDMEEATLHFETTSaslkkrhadslaeLEGQVENLQQVKQKLEKDKSDLQLE 1239
Cdd:TIGR04523  552 FEL--------------KKENLEKEIDEKNKEIEELKQTQKS-------------LKKKQEEKQELIDQKEKEKKDLIKE 604
                          410       420
                   ....*....|....*....|
gi 767926067  1240 VDDLLTRVEQMTRAKANAEK 1259
Cdd:TIGR04523  605 IEEKEKKISSLEKELEKAKK 624
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1089-1302 1.45e-09

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 62.09  E-value: 1.45e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1089 AEELRKKELELSQMNSKVENEKGLVAQLQKTVKELQTQIKDLKEKLEAERTTRAKMERERADLTQDLADLNERLEEVGGS 1168
Cdd:COG4942    19 ADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAE 98
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1169 SLAQLEITKKQETKFQKLHR-DMEEATLHFETTSASLKKRH---------ADSLAELEGQVENLQQVKQKLEKDKSDLQL 1238
Cdd:COG4942    99 LEAQKEELAELLRALYRLGRqPPLALLLSPEDFLDAVRRLQylkylaparREQAEELRADLAELAALRAELEAERAELEA 178
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767926067 1239 EVDDLLTRVEQMTRAKANAEKLCTLYEERLHEATAKLDKVTQLANDLAAQKTKLWSESGEFLRR 1302
Cdd:COG4942   179 LLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAER 242
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
859-1338 2.19e-09

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 62.75  E-value: 2.19e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  859 EEVAGLKEECAQLQKALEKSEFQREELK-------AKQVSLTQEKNDLILQLQAEQETLANVEEQCEWLIKSKIQLEARV 931
Cdd:PRK02224  251 EELETLEAEIEDLRETIAETEREREELAeevrdlrERLEELEEERDDLLAEAGLDDADAEAVEARREELEDRDEELRDRL 330
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  932 KELSERVEEEEEINSELTARGRKLEDECFELKKEIDDLETMLVKSEKEKRTTEHKVKNLTEEVEFLNE---DISKLNRAA 1008
Cdd:PRK02224  331 EECRVAAQAHNEEAESLREDADDLEERAEELREEAAELESELEEAREAVEDRREEIEELEEEIEELRErfgDAPVDLGNA 410
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1009 KVVQEAHQQTLDDLHME----EEKLSSLSKANLKLEQQVDE---------LEG-----ALEQERKARMNCERELHKLEgn 1070
Cdd:PRK02224  411 EDFLEELREERDELREReaelEATLRTARERVEEAEALLEAgkcpecgqpVEGsphveTIEEDRERVEELEAELEDLE-- 488
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1071 lkLNRESMEN-LESsqrhlAEELRKKELELSQMNSKVENEKGLVAQLQKTVKELQTQIKDL---KEKLEAE----RTTRA 1142
Cdd:PRK02224  489 --EEVEEVEErLER-----AEDLVEAEDRIERLEERREDLEELIAERRETIEEKRERAEELrerAAELEAEaeekREAAA 561
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1143 KMERERADLTQDLADLNERLEEVgGSSLAQLEITKKQETKFQKLHRDMEEatlhfettsasLKKRHADsLAELEGQVEnl 1222
Cdd:PRK02224  562 EAEEEAEEAREEVAELNSKLAEL-KERIESLERIRTLLAAIADAEDEIER-----------LREKREA-LAELNDERR-- 626
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1223 QQVKQKLEKdKSDLQLEVDDllTRVEQMTRAKANAEKLCTLYEERLHEATAKLDKvtqLANDLAAQKTKLwsESGEFLRr 1302
Cdd:PRK02224  627 ERLAEKRER-KRELEAEFDE--ARIEEAREDKERAEEYLEQVEEKLDELREERDD---LQAEIGAVENEL--EELEELR- 697
                         490       500       510
                  ....*....|....*....|....*....|....*...
gi 767926067 1303 lEEKEALINQLSREKS--NFTRQIEDLRGQLEKETKSQ 1338
Cdd:PRK02224  698 -ERREALENRVEALEAlyDEAEELESMYGDLRAELRQR 734
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
1511-1868 3.01e-09

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 62.06  E-value: 3.01e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1511 RRENKNLQEEISNLTNQ--VREGTKNLTEMEKVKKLIEEEKTEVQVTLEETEGALERNESKILHFQLELLEAKAELERKL 1588
Cdd:pfam17380  239 RKESFNLAEDVTTMTPEytVRYNGQTMTENEFLNQLLHIVQHQKAVSERQQQEKFEKMEQERLRQEKEEKAREVERRRKL 318
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1589 SEKdEEIENFRRKQQCTIDSLQSSLDSEAKSRIEVTRL--KKKMEEDLNEMELQLSCanrqvsEATKSLGQLQIQIKDLQ 1666
Cdd:pfam17380  319 EEA-EKARQAEMDRQAAIYAEQERMAMERERELERIRQeeRKRELERIRQEEIAMEI------SRMRELERLQMERQQKN 391
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1667 MQLDDSTQLNSDLKEQVAVAERRNSLLQSELEDLRSLQEQT-ERGRRLSEEELLEATERINLFYTQNTSLLSQKKKLEAD 1745
Cdd:pfam17380  392 ERVRQELEAARKVKILEEERQRKIQQQKVEMEQIRAEQEEArQREVRRLEEERAREMERVRLEEQERQQQVERLRQQEEE 471
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1746 VARMQKEAEEVVQECQNAEEKAKKAaieaanLSEELKKKQDTIAHLERTRENMEQTITDLQKRLAEAEQ--MALMGSRKQ 1823
Cdd:pfam17380  472 RKRKKLELEKEKRDRKRAEEQRRKI------LEKELEERKQAMIEEERKRKLLEKEMEERQKAIYEEERrrEAEEERRKQ 545
                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*
gi 767926067  1824 IQKLESRVRELEGELEGEIRRSAEAQRGARRLERCIKELTYQAEE 1868
Cdd:pfam17380  546 QEMEERRRIQEQMRKATEERSRLEAMEREREMMRQIVESEKARAE 590
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
859-1404 3.06e-09

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 61.96  E-value: 3.06e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   859 EEVAGLKEECAQLQKALEKSEFQREELKAKQVSLTQEKNDLILQLQAEQETLANVEEQCEWLIKSKIQLEARVKELSERV 938
Cdd:TIGR04523   75 NKIKILEQQIKDLNDKLKKNKDKINKLNSDLSKINSEIKNDKEQKNKLEVELNKLEKQKKENKKNIDKFLTEIKKKEKEL 154
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   939 EEEEEINSELTARGRKLEDECFELKKEIDDLETMLVKSEKEKRTTEHKV----------KNLTEEVEFLNEDISKLNRAA 1008
Cdd:TIGR04523  155 EKLNNKYNDLKKQKEELENELNLLEKEKLNIQKNIDKIKNKLLKLELLLsnlkkkiqknKSLESQISELKKQNNQLKDNI 234
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1009 KVVQEAHQQTLDDLHMEEEKLSSLSKANLKLEQQVDELEGALEQERKARMNCERELHKLEGNLK-LNRESMEN----LES 1083
Cdd:TIGR04523  235 EKKQQEINEKTTEISNTQTQLNQLKDEQNKIKKQLSEKQKELEQNNKKIKELEKQLNQLKSEISdLNNQKEQDwnkeLKS 314
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1084 SQRHLAEELRKKELELSQMNSKVENEKGLVAQLQKTVKELQTQIKDLKEKLEAERTTRAKMERERADLTQDLADLNERLE 1163
Cdd:TIGR04523  315 ELKNQEKKLEEIQNQISQNNKIISQLNEQISQLKKELTNSESENSEKQRELEEKQNEIEKLKKENQSYKQEIKNLESQIN 394
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1164 EVGGSSLAQLEITKKQETKFQKLHRDMEEatlhfettsasLKKRHADslaeLEGQVENLQQVKQKLEKDKSDLQLEVDDL 1243
Cdd:TIGR04523  395 DLESKIQNQEKLNQQKDEQIKKLQQEKEL-----------LEKEIER----LKETIIKNNSEIKDLTNQDSVKELIIKNL 459
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1244 LTRVEQMTRAKANAEKLCTLYEERLHEATAKLDKVTQLANDLAAQKTKLWSESGEFLRRLEEKEALINQLSREKSNFTRQ 1323
Cdd:TIGR04523  460 DNTRESLETQLKVLSRSINKIKQNLEQKQKELKSKEKELKKLNEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEKESK 539
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1324 IEDLRGQLEK--ETKSQSALAHALQKAQRDCDLLREQYEE---EQEVKAELHRTLSKVNAEMVQWRMKYENNVIQRTEDL 1398
Cdd:TIGR04523  540 ISDLEDELNKddFELKKENLEKEIDEKNKEIEELKQTQKSlkkKQEEKQELIDQKEKEKKDLIKEIEEKEKKISSLEKEL 619

                   ....*.
gi 767926067  1399 EDAKKE 1404
Cdd:TIGR04523  620 EKAKKE 625
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
961-1601 1.59e-08

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 59.93  E-value: 1.59e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  961 ELKKEIDDLETMlvksEKEKRTTEHKVKNLTEEVEfLNEDISKLnRAAKVVQEAHQQTLDDLHmEEEKLSSLSKANLKLE 1040
Cdd:COG4913   229 ALVEHFDDLERA----HEALEDAREQIELLEPIRE-LAERYAAA-RERLAELEYLRAALRLWF-AQRRLELLEAELEELR 301
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1041 QQVDELEGALEQERKARMNCERELHKLEGNL-KLNRESMENLESSQRHLAEELRKKELELSQMNSKVENEKGLVAQLQKT 1119
Cdd:COG4913   302 AELARLEAELERLEARLDALREELDELEAQIrGNGGDRLEQLEREIERLERELEERERRRARLEALLAALGLPLPASAEE 381
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1120 VKELQTQIKDLKEKLEAERttrAKMERERADLTQDLADLNERLEEVggssLAQLEITKKQET----KFQKLHRDMEEATl 1195
Cdd:COG4913   382 FAALRAEAAALLEALEEEL---EALEEALAEAEAALRDLRRELREL----EAEIASLERRKSnipaRLLALRDALAEAL- 453
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1196 hfettsaSLKKRHADSLAEL----------EGQVE---------------NLQQVKQKLE--KDKSDLQLEVDDLLTRVE 1248
Cdd:COG4913   454 -------GLDEAELPFVGELievrpeeerwRGAIErvlggfaltllvppeHYAAALRWVNrlHLRGRLVYERVRTGLPDP 526
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1249 QMTRAKAN--AEKLctlyEERLHEATA-------------KLDKVTQLAN-DLAAQKTKLWSESGEF------------- 1299
Cdd:COG4913   527 ERPRLDPDslAGKL----DFKPHPFRAwleaelgrrfdyvCVDSPEELRRhPRAITRAGQVKGNGTRhekddrrrirsry 602
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1300 ------LRRLEEKEALINQLSREKSNFTRQIEDLRGQLEketksqsalahALQKAQRDCDLLREQYEEEQEVkAELHRTL 1373
Cdd:COG4913   603 vlgfdnRAKLAALEAELAELEEELAEAEERLEALEAELD-----------ALQERREALQRLAEYSWDEIDV-ASAEREI 670
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1374 SKVNAEMvqwrmkyennviqrtEDLEDAKKELairlqeaaeamgvanarnASLERARHQLQLELGDALSDLGKVRSAAAR 1453
Cdd:COG4913   671 AELEAEL---------------ERLDASSDDL------------------AALEEQLEELEAELEELEEELDELKGEIGR 717
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1454 LDQKqlqsgkaLADWKQKHEESQALLDASQKEVQALSTELLklkNTYEESIVGQETLRRENKNLQEEISNLTNQVREGTK 1533
Cdd:COG4913   718 LEKE-------LEQAEEELDELQDRLEAAEDLARLELRALL---EERFAAALGDAVERELRENLEERIDALRARLNRAEE 787
                         650       660       670       680       690       700       710
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767926067 1534 NLTE-MEKVKKLIEEEKTEVQVTLEETEGALERneskilHFQLE---LLEAKAELERKLSE-KDEEIENFRRK 1601
Cdd:COG4913   788 ELERaMRAFNREWPAETADLDADLESLPEYLAL------LDRLEedgLPEYEERFKELLNEnSIEFVADLLSK 854
PTZ00121 PTZ00121
MAEBL; Provisional
1246-1933 1.82e-08

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 60.15  E-value: 1.82e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1246 RVEQMTRAKA--NAEKLCTLYEERLHEATAKLDKVTQLANDLAAQKTKLWSES--GEFLRRLEEkealinqlSREKSNFT 1321
Cdd:PTZ00121 1171 KAEDAKKAEAarKAEEVRKAEELRKAEDARKAEAARKAEEERKAEEARKAEDAkkAEAVKKAEE--------AKKDAEEA 1242
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1322 RQIEDLRGQLEKETKSQSALAH-----ALQKAQ--RDCDLLREQyeEEQEVKAELHRTLSKVNAEMVQWRMKYENNVIQR 1394
Cdd:PTZ00121 1243 KKAEEERNNEEIRKFEEARMAHfarrqAAIKAEeaRKADELKKA--EEKKKADEAKKAEEKKKADEAKKKAEEAKKADEA 1320
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1395 TEDLEDAKKELAIRLQEAAEAMGVANARNASLERARHQLQLELGDALSDLGKVRSAaarldQKQLQSGKALADWKQKHEE 1474
Cdd:PTZ00121 1321 KKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEA-----KKKADAAKKKAEEKKKADE 1395
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1475 SQALLDASQKEVQALSTELLKLKNTYEESIVGQETLRRENKNLQEEISNLTNQVREGTKNLTEMEKVKKLIEEEKTevqv 1554
Cdd:PTZ00121 1396 AKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKK---- 1471
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1555 TLEETEGALERNESKILHFQLELLEAKAELERKLSEKDEEIENFRRKQQC-TIDSLQSSLDSEAKSRIEVTRLKKKMEED 1633
Cdd:PTZ00121 1472 ADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAkKADEAKKAEEAKKADEAKKAEEKKKADEL 1551
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1634 LNEMELQLSCANRQVSEATK-------SLGQLQIQIKDLQMQLDDSTQLNSDLKEQVAVAERRNSLLQSELEDLRSLQE- 1705
Cdd:PTZ00121 1552 KKAEELKKAEEKKKAEEAKKaeedknmALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEe 1631
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1706 --QTERGRRLSEEELLEATERINLFYTQNTSLLSQKKKLEADvarmQKEAEEVVQEcqnaEEKAKKAAIEAANLSEELKK 1783
Cdd:PTZ00121 1632 kkKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEED----KKKAEEAKKA----EEDEKKAAEALKKEAEEAKK 1703
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1784 KQDTIAHLERTRENMEQTITDLQKRLAEAEQMALMGSRKQIQKLESRVRELEGELEGEIRRSAEAQRGARRLErciKELT 1863
Cdd:PTZ00121 1704 AEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKE---KEAV 1780
                         650       660       670       680       690       700       710
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1864 YQAEEDKKNLSRMQTQMDKLQLKVQNYKQQVEvAETQANQYLSKYKkqQHELNEVKERAEVAESQVNKLK 1933
Cdd:PTZ00121 1781 IEEELDEEDEKRRMEVDKKIKDIFDNFANIIE-GGKEGNLVINDSK--EMEDSAIKEVADSKNMQLEEAD 1847
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
1545-1923 2.07e-08

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 59.67  E-value: 2.07e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1545 IEEEKTEVQVTLEETEGALERNESKILHFQLelleakAELERKLSEKDEEIENF---RRKQQCTIDSLQSSLDSEAKSRI 1621
Cdd:PRK02224  178 VERVLSDQRGSLDQLKAQIEEKEEKDLHERL------NGLESELAELDEEIERYeeqREQARETRDEADEVLEEHEERRE 251
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1622 EVTRLK---KKMEEDLNEMELQLSCANRQVSEATKSLGQLQIQIKDL--QMQLDDStqlnsdlkEQVAVAERRnsllqse 1696
Cdd:PRK02224  252 ELETLEaeiEDLRETIAETEREREELAEEVRDLRERLEELEEERDDLlaEAGLDDA--------DAEAVEARR------- 316
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1697 lEDLRSLQEQTErgrrlseEELLEATERINLFYTQNTSLLSQKKKLEADVARMQKEAEEVVQECQNAEEKAKKAAIEAAN 1776
Cdd:PRK02224  317 -EELEDRDEELR-------DRLEECRVAAQAHNEEAESLREDADDLEERAEELREEAAELESELEEAREAVEDRREEIEE 388
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1777 LSEELKKKQDTIA-----------HLERTREN----------MEQTITDLQKRLAEAEQM-------------------- 1815
Cdd:PRK02224  389 LEEEIEELRERFGdapvdlgnaedFLEELREErdelrereaeLEATLRTARERVEEAEALleagkcpecgqpvegsphve 468
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1816 ALMGSRKQIQKLESR---VRELEGELEGEIRRSAEAQRGARRLERC----------IKELTYQAEEDKKNLSRMQTQMDK 1882
Cdd:PRK02224  469 TIEEDRERVEELEAEledLEEEVEEVEERLERAEDLVEAEDRIERLeerredleelIAERRETIEEKRERAEELRERAAE 548
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 767926067 1883 LQLKVQNYKQQVEVAETQANQYLSKYKKQQHELNEVKERAE 1923
Cdd:PRK02224  549 LEAEAEEKREAAAEAEEEAEEAREEVAELNSKLAELKERIE 589
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1007-1235 2.57e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 58.24  E-value: 2.57e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1007 AAKVVQEAHQQTLDDLhmeEEKLSSLSKANLKLEQQVDELEGALEQERKARMNCERELHKLEGNLKLNRESMENLESSQR 1086
Cdd:COG4942    17 AQADAAAEAEAELEQL---QQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIA 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1087 HLAEELRKKELELS------QMNSKVENEKGLVAQ------------LQKTVKELQTQIKDLKEKLEAERTTRAKMERER 1148
Cdd:COG4942    94 ELRAELEAQKEELAellralYRLGRQPPLALLLSPedfldavrrlqyLKYLAPARREQAEELRADLAELAALRAELEAER 173
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1149 ADLTQDLADLNERLEEvggssLAQLEitKKQETKFQKLHRDmeeatlhfettsaslKKRHADSLAELEGQVENLQQVKQK 1228
Cdd:COG4942   174 AELEALLAELEEERAA-----LEALK--AERQKLLARLEKE---------------LAELAAELAELQQEAEELEALIAR 231

                  ....*..
gi 767926067 1229 LEKDKSD 1235
Cdd:COG4942   232 LEAEAAA 238
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1186-1827 3.17e-08

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 59.16  E-value: 3.17e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1186 LHRDMEEAtlhfettsaslkKRHADSLAELEGQVENLQQVKQKLEkdksdlqlEVDDLLTRVEQMTRAKANAeklctLYE 1265
Cdd:COG4913   240 AHEALEDA------------REQIELLEPIRELAERYAAARERLA--------ELEYLRAALRLWFAQRRLE-----LLE 294
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1266 ERLHEATAKLDKVTQLANDLAAQKTKLwsesgeflrrLEEKEALINQLSrekSNFTRQIEDLRGQLEKETKSQSALAHAL 1345
Cdd:COG4913   295 AELEELRAELARLEAELERLEARLDAL----------REELDELEAQIR---GNGGDRLEQLEREIERLERELEERERRR 361
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1346 QKAQRDCDLLREQYEEEQEVKAELHRTLSKVNAEMVQWRMKYENNVIQRTEDLEDAKKELAIRLQEAAEAMGVANARNAS 1425
Cdd:COG4913   362 ARLEALLAALGLPLPASAEEFAALRAEAAALLEALEEELEALEEALAEAEAALRDLRRELRELEAEIASLERRKSNIPAR 441
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1426 LERARHQLQLELGDALSDL---------------------GKVRSAAARL--DQKQLqsgKALADW----KQKH------ 1472
Cdd:COG4913   442 LLALRDALAEALGLDEAELpfvgelievrpeeerwrgaieRVLGGFALTLlvPPEHY---AAALRWvnrlHLRGrlvyer 518
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1473 -EESQALLDASQKEVQALSTELLKLKNTYE---ESIVGQ----------ETLRRENKNLQEE--IS--------NLTNQV 1528
Cdd:COG4913   519 vRTGLPDPERPRLDPDSLAGKLDFKPHPFRawlEAELGRrfdyvcvdspEELRRHPRAITRAgqVKgngtrhekDDRRRI 598
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1529 RE----GTKNLtemEKVKKLiEEEKTEVQVTLEETEGALERNESkilhfQLELLEAKAELERKLSEKDEEIENFRRKQQc 1604
Cdd:COG4913   599 RSryvlGFDNR---AKLAAL-EAELAELEEELAEAEERLEALEA-----ELDALQERREALQRLAEYSWDEIDVASAER- 668
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1605 TIDSLQSSLDSEAKSRIEVTRLKKKMEE---DLNEMELQLSCANRQVSEATKSLGQLQIQIKDLQMQLDD-----STQLN 1676
Cdd:COG4913   669 EIAELEAELERLDASSDDLAALEEQLEEleaELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAaedlaRLELR 748
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1677 SDLKEQVAVAERRNSlLQSELEDLRSLQEQTERGRRLSEEELLEATERINLFYTQNTSLLSqkkkleADVArmqkEAEEV 1756
Cdd:COG4913   749 ALLEERFAAALGDAV-ERELRENLEERIDALRARLNRAEEELERAMRAFNREWPAETADLD------ADLE----SLPEY 817
                         650       660       670       680       690       700       710
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767926067 1757 VQECQNAEekakkaaieaanlSEELKKKQDTIAhlERTRENMEQTITDLQKRLAEAEQMAlmgsRKQIQKL 1827
Cdd:COG4913   818 LALLDRLE-------------EDGLPEYEERFK--ELLNENSIEFVADLLSKLRRAIREI----KERIDPL 869
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1266-1895 3.38e-08

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 58.92  E-value: 3.38e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1266 ERLHEATAKLDKVTQLANDLAAQKTKLWSESGEFLRRLEEKEALINQLSREKSNFTRQIEDLRGQLEKetksqsalahaL 1345
Cdd:PRK03918  158 DDYENAYKNLGEVIKEIKRRIERLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREELEK-----------L 226
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1346 QKAQRDCDLLREQYEEEQEVKAELHRTLSKVNAEMVQWRmKYENNVIQRTEDLEDAKKELAiRLQEAAEAMGVANARNAS 1425
Cdd:PRK03918  227 EKEVKELEELKEEIEELEKELESLEGSKRKLEEKIRELE-ERIEELKKEIEELEEKVKELK-ELKEKAEEYIKLSEFYEE 304
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1426 LERARHQLQLELGD----------ALSDLGKVRSAAARLDQKQLQSGKALADWKQKHEESQALLdASQKEVQALSTELL- 1494
Cdd:PRK03918  305 YLDELREIEKRLSRleeeingieeRIKELEEKEERLEELKKKLKELEKRLEELEERHELYEEAK-AKKEELERLKKRLTg 383
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1495 ----KLKNTYEESIVGQETLRRENKNLQEEISNLTNQVREGTKNLTEMEKVKKLIEEEKTEVqvTLEETEGALERNESKI 1570
Cdd:PRK03918  384 ltpeKLEKELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKKAKGKCPVCGREL--TEEHRKELLEEYTAEL 461
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1571 LHFQLELLEAKaELERKLSEKDEEIENFRRKQqctidslqssldSEAKSRIEVTRLKKKMEEDLNEMELQ-LSCANRQVS 1649
Cdd:PRK03918  462 KRIEKELKEIE-EKERKLRKELRELEKVLKKE------------SELIKLKELAEQLKELEEKLKKYNLEeLEKKAEEYE 528
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1650 EATKSLGQLQIQIKDLQMQLDDSTQLNSDLKEqvavAERRNSLLQSELEDLrsLQEQTERGRRlSEEELLEATERINLFY 1729
Cdd:PRK03918  529 KLKEKLIKLKGEIKSLKKELEKLEELKKKLAE----LEKKLDELEEELAEL--LKELEELGFE-SVEELEERLKELEPFY 601
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1730 TQNTSLLSQKKKLEADVARMQKEAEEvvqecqnaeekakkaaieaanlseelkkkqdtiahLERTRENMEQTITDLQKRL 1809
Cdd:PRK03918  602 NEYLELKDAEKELEREEKELKKLEEE-----------------------------------LDKAFEELAETEKRLEELR 646
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1810 AEAEQMALMGSRKQIQKLESRVRELEGELEGEIRRSAEAQRGARRLERCIKELTYQAEEDKK------NLSRMQTQMDKL 1883
Cdd:PRK03918  647 KELEELEKKYSEEEYEELREEYLELSRELAGLRAELEELEKRREEIKKTLEKLKEELEEREKakkeleKLEKALERVEEL 726
                         650
                  ....*....|..
gi 767926067 1884 QLKVQNYKQQVE 1895
Cdd:PRK03918  727 REKVKKYKALLK 738
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
853-1223 3.64e-08

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 58.90  E-value: 3.64e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  853 KSSEVGEEVAGLKEECAQLQKALEKSEFQREELKAKQVSLTQEKNDLILQLQAEQETLANVEEQCEWLIKSKIQLEARVK 932
Cdd:PRK02224  357 RAEELREEAAELESELEEAREAVEDRREEIEELEEEIEELRERFGDAPVDLGNAEDFLEELREERDELREREAELEATLR 436
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  933 ELSERVEEeeeiNSELTARGRKLE-----------DECFELKKEIDDLETMLVKSEKEKRTTEHKVKNLTEEVEFLNEDI 1001
Cdd:PRK02224  437 TARERVEE----AEALLEAGKCPEcgqpvegsphvETIEEDRERVEELEAELEDLEEEVEEVEERLERAEDLVEAEDRIE 512
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1002 SKLNRAAKVVQ--EAHQQTLDDlhmEEEKLSSLSKANLKLEQQVDELEGALEQERKARMNCERELHKLEGNLKLNRESME 1079
Cdd:PRK02224  513 RLEERREDLEEliAERRETIEE---KRERAEELRERAAELEAEAEEKREAAAEAEEEAEEAREEVAELNSKLAELKERIE 589
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1080 NLESSqRHLAEELRKKELELSQMNSKVENEKGLVAQLQKTVKELQTQIKDLKEKLEAERTTRAKMERERA-----DLTQD 1154
Cdd:PRK02224  590 SLERI-RTLLAAIADAEDEIERLREKREALAELNDERRERLAEKRERKRELEAEFDEARIEEAREDKERAeeyleQVEEK 668
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767926067 1155 LADLNER----LEEVGG--SSLAQLEITKKQETKFQKLHRDMEeaTLHFETTsaSLKKRHADSLAELEGQ-VENLQ 1223
Cdd:PRK02224  669 LDELREErddlQAEIGAveNELEELEELRERREALENRVEALE--ALYDEAE--ELESMYGDLRAELRQRnVETLE 740
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
1091-1298 5.25e-08

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 57.15  E-value: 5.25e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1091 ELRKKELELSQMNSKVENEKGLVAQLQKTVKELQTQIKDLKEKLEAERTTRAKMERERADLTQDLADLNERLEE------ 1164
Cdd:COG3883    17 QIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGEraraly 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1165 VGGSSLAQLE--------------------ITKKQETKFQKLHRDMEEAtlhfettsASLKKRHADSLAELEGQVENLQQ 1224
Cdd:COG3883    97 RSGGSVSYLDvllgsesfsdfldrlsalskIADADADLLEELKADKAEL--------EAKKAELEAKLAELEALKAELEA 168
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767926067 1225 VKQKLEKDKSDLQLEVDDLLTRVEQMTRAKANAEKLCTLYEERLHEATAKLDKVTQLANDLAAQKTKLWSESGE 1298
Cdd:COG3883   169 AKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA 242
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
986-1193 7.06e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 56.70  E-value: 7.06e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  986 KVKNLTEEVEFLNEDISKLNRAAKVVQEAHQQTLDDLHMEEEKLSSLSKANLKLEQQVDELEGALEQERKARMNCERELH 1065
Cdd:COG4942    21 AAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELE 100
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1066 KLEGNL--------KLNRESMENLESSQRHLAEELRKKELelsqMNSKVENEKGLVAQLQKTVKELQTQIKDLKEKLEAE 1137
Cdd:COG4942   101 AQKEELaellralyRLGRQPPLALLLSPEDFLDAVRRLQY----LKYLAPARREQAEELRADLAELAALRAELEAERAEL 176
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 767926067 1138 RTTRAKMERERADLTQDLADLNERLEEVGG---SSLAQLEITKKQETKFQKLHRDMEEA 1193
Cdd:COG4942   177 EALLAELEEERAALEALKAERQKLLARLEKelaELAAELAELQQEAEELEALIARLEAE 235
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
859-1285 7.78e-08

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 57.47  E-value: 7.78e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  859 EEVAGLKEECAQLQKALEKSEFQREELKAKQVSLTQEKNDL--ILQLQAEQETLANVEEQCEWLIKSKIQLEARVKELSE 936
Cdd:COG4717    81 KEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLekLLQLLPLYQELEALEAELAELPERLEELEERLEELRE 160
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  937 RVEEEEEINSELTARGRKLEDEC----FELKKEIDDLETMLVKSEKEKRTTEHKVKNLTEEVEFLNEDISKLNRAAKVVQ 1012
Cdd:COG4717   161 LEEELEELEAELAELQEELEELLeqlsLATEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAA 240
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1013 EAHQ-----------------QTLDDLHMEEEK----------------LSSLSKANLKLEQQVDELEGALEQERKARMN 1059
Cdd:COG4717   241 LEERlkearlllliaaallalLGLGGSLLSLILtiagvlflvlgllallFLLLAREKASLGKEAEELQALPALEELEEEE 320
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1060 CERELHKLEGNLKLNRESMENLESSQRHLAEELRKKELELSQmnskvenekglvAQLQKTVKELQTQIKDLKEKLEAERT 1139
Cdd:COG4717   321 LEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEE------------LQLEELEQEIAALLAEAGVEDEEELR 388
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1140 TRAKMERERADLTQDLADLNERLEEVGGSSLAQLEITKKQ--ETKFQKLHRDMEEAtlhfettsASLKKRHADSLAELEG 1217
Cdd:COG4717   389 AALEQAEEYQELKEELEELEEQLEELLGELEELLEALDEEelEEELEELEEELEEL--------EEELEELREELAELEA 460
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767926067 1218 QVENLQQvkqklEKDKSDLQLEVDDLLTRVEQMTRAKANAEKLCTLYEERLHEAT-AKLDKVTQLANDL 1285
Cdd:COG4717   461 ELEQLEE-----DGELAELLQELEELKAELRELAEEWAALKLALELLEEAREEYReERLPPVLERASEY 524
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1627-1854 9.51e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 56.31  E-value: 9.51e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1627 KKKMEEDLNEMELQLSCANRQVSEATKSLGQLQIQIKDLQMQLDDSTQLNSDLKEQVAVAERRNSLLQSELEDLR-SLQE 1705
Cdd:COG4942    22 AAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRaELEA 101
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1706 QTER-GRRLSEEELLEATERINLFYTQNTSLLSQK--KKLEADVARMQKEAEEVVQECQNAEEKAKKAAIEAANLSEELK 1782
Cdd:COG4942   102 QKEElAELLRALYRLGRQPPLALLLSPEDFLDAVRrlQYLKYLAPARREQAEELRADLAELAALRAELEAERAELEALLA 181
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767926067 1783 KKQDTIAHLERTRENMEQTITDLQKRLAEAEQmALMGSRKQIQKLESRVRELEGELEGEIRRSAEAQRGARR 1854
Cdd:COG4942   182 ELEEERAALEALKAERQKLLARLEKELAELAA-ELAELQQEAEELEALIARLEAEAAAAAERTPAAGFAALK 252
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
865-1516 1.31e-07

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 56.90  E-value: 1.31e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   865 KEECAQLQKALEKSEFQREELKAKQVSLTQEKNDLILQLQAEQETLANVEEQcEWLIKSKIQLEARVKELSERVEEEEEI 944
Cdd:TIGR00618  292 AAPLAAHIKAVTQIEQQAQRIHTELQSKMRSRAKLLMKRAAHVKQQSSIEEQ-RRLLQTLHSQEIHIRDAHEVATSIREI 370
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   945 NS---ELTARGRKLEDEcfelkKEIDDLETMLVKSEKEKRTTE-HKVKNLTEEVEFLNEDISKLN-------RAAKVVQE 1013
Cdd:TIGR00618  371 SCqqhTLTQHIHTLQQQ-----KTTLTQKLQSLCKELDILQREqATIDTRTSAFRDLQGQLAHAKkqqelqqRYAELCAA 445
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1014 AHQQTLDDLHMEEEKLSSLSKANLKLEQQVDELEGALEQerkarmncERELHKLEGNLKlnresmENLESSQRHLAEELR 1093
Cdd:TIGR00618  446 AITCTAQCEKLEKIHLQESAQSLKEREQQLQTKEQIHLQ--------ETRKKAVVLARL------LELQEEPCPLCGSCI 511
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1094 KKELELSQMNSKVENEKgLVAQLQKTVKELQTQIKDLKEKLEAERTTRAKMERERADLTQDLADLNERLEEVGgsslAQL 1173
Cdd:TIGR00618  512 HPNPARQDIDNPGPLTR-RMQRGEQTYAQLETSEEDVYHQLTSERKQRASLKEQMQEIQQSFSILTQCDNRSK----EDI 586
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1174 EITKKQETKFQKL--HRDMEEATLHFETTSASLKKRHADSLAELEGQVENLQQVKQKLEKDKSDLQLEvddlLTRVEQMT 1251
Cdd:TIGR00618  587 PNLQNITVRLQDLteKLSEAEDMLACEQHALLRKLQPEQDLQDVRLHLQQCSQELALKLTALHALQLT----LTQERVRE 662
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1252 RAKANAEKLCTLYEERLHEATAKLDKVTQLANDLAAQKTKLwsesgEFLRRLEEKEALINQLSREKSNFTR-QIEDLRGQ 1330
Cdd:TIGR00618  663 HALSIRVLPKELLASRQLALQKMQSEKEQLTYWKEMLAQCQ-----TLLRELETHIEEYDREFNEIENASSsLGSDLAAR 737
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1331 LEketksqsALAHALQKAQRDCDLLREQYEEEQEVKAELHRTLSKVNAEMVQWRMKYENNVIQRTEDLEDAKKELAIRLQ 1410
Cdd:TIGR00618  738 ED-------ALNQSLKELMHQARTVLKARTEAHFNNNEEVTAALQTGAELSHLAAEIQFFNRLREEDTHLLKTLEAEIGQ 810
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1411 EAAEAMGVANARNASLERARHQLQLELGDALSDLGKVRSAAARLDQKQLQSGKALADWKQKHEESQALLDASQKEVQALS 1490
Cdd:TIGR00618  811 EIPSDEDILNLQCETLVQEEEQFLSRLEEKSATLGEITHQLLKYEECSKQLAQLTQEQAKIIQLSDKLNGINQIKIQFDG 890
                          650       660       670
                   ....*....|....*....|....*....|....*...
gi 767926067  1491 TELLK------------LKNTYEESIVGQETLRRENKN 1516
Cdd:TIGR00618  891 DALIKflheitlyanvrLANQSEGRFHGRYADSHVNAR 928
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1039-1278 1.59e-07

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 56.85  E-value: 1.59e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1039 LEQQVDELEGALEQERKARMNCERELHKLEGNLKLNRESMENLESSQRH--LAEELRKKELELSQmnskVENEKGLVAQL 1116
Cdd:COG4913   615 LEAELAELEEELAEAEERLEALEAELDALQERREALQRLAEYSWDEIDVasAEREIAELEAELER----LDASSDDLAAL 690
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1117 QKTVKELQTQIKDLKEKLEAERTTRAKMERERADLTQDLADLNERLEEVGGSS-----------LAQLEITKKQETKFQK 1185
Cdd:COG4913   691 EEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLArlelralleerFAAALGDAVERELREN 770
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1186 LHRDMEEATLHFETTSASL-------KKRHADSLAELEGQVENLQQVKQKLEkdksdlQLEVDDLLTRVEQMTRAKANAE 1258
Cdd:COG4913   771 LEERIDALRARLNRAEEELeramrafNREWPAETADLDADLESLPEYLALLD------RLEEDGLPEYEERFKELLNENS 844
                         250       260
                  ....*....|....*....|....*
gi 767926067 1259 K-----LCTLYEERLHEATAKLDKV 1278
Cdd:COG4913   845 IefvadLLSKLRRAIREIKERIDPL 869
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
853-1242 1.64e-07

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 56.61  E-value: 1.64e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   853 KSSEVGEEVAGLKEECAQLQKALEKSEFQREELKAKQVSLTQEKNDLILQLQAEQETLANVEEQCEWLIKSKIQLEARVK 932
Cdd:TIGR02169  710 ELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEEALNDLEARLS 789
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   933 ELSERveeeeeinsELTARGRKLEDECFELKKEIDDLETMLVKSEKEKRTTEHKVKNLTEEVEFLNEDISklnraakvvq 1012
Cdd:TIGR02169  790 HSRIP---------EIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIK---------- 850
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1013 eahqqtlddlhMEEEKLSSLSKANLKLEQQVDELEGALEQERKARMNCERELHKLEgnlklnrESMENLESSQRHLAEEL 1092
Cdd:TIGR02169  851 -----------SIEKEIENLNGKKEELEEELEELEAALRDLESRLGDLKKERDELE-------AQLRELERKIEELEAQI 912
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1093 RKKELELSQMNSKVENEKGLVAQLQKTVKELQtqiKDLKEKLEAErttraKMERERADLTQDLadlnERLEEVGGSSLAQ 1172
Cdd:TIGR02169  913 EKKRKRLSELKAKLEALEEELSEIEDPKGEDE---EIPEEELSLE-----DVQAELQRVEEEI----RALEPVNMLAIQE 980
                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767926067  1173 LEITKKQETKFQ-KLHRDMEEATLHFETTSASLKKRHADSLAELEGQVENLQQVKQKLEKDKSDLQLEVDD 1242
Cdd:TIGR02169  981 YEEVLKRLDELKeKRAKLEEERKAILERIEEYEKKKREVFMEAFEAINENFNEIFAELSGGTGELILENPD 1051
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1061-1259 1.87e-07

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 55.54  E-value: 1.87e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1061 ERELHKLEGNLKLNRESMENLESSQRHLAEELRKKELELSQMNSKVENEKGLVAQLQKTVKELQTQIKDLKEKLEAERTT 1140
Cdd:COG4942    26 EAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQKEE 105
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1141 RAKM--------ERERADL---TQDLADLNERLEEVGGSSLAQLEITKKQETKFQKLHRDMEEATLHFETTSAsLKKRHA 1209
Cdd:COG4942   106 LAELlralyrlgRQPPLALllsPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELEA-LLAELE 184
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 767926067 1210 DSLAELEGQVENLQQVKQKLEKDKSDLQLEVDDLLTRVEQMTRAKANAEK 1259
Cdd:COG4942   185 EERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEA 234
mukB PRK04863
chromosome partition protein MukB;
1318-1724 2.19e-07

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 56.50  E-value: 2.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1318 SNFTRQIEDLRGQLEKETKSQSALAHA---LQKAQRDCDLLREQYEEEQEVKAELHRTLSKVNAEM--VQWRMKYENNVI 1392
Cdd:PRK04863  272 ADYMRHANERRVHLEEALELRRELYTSrrqLAAEQYRLVEMARELAELNEAESDLEQDYQAASDHLnlVQTALRQQEKIE 351
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1393 QRTEDLEdakkELAIRLQEAAEAMGVANARNASLERarhqlqlelgdalsdlgkvRSAAARLDQKQLQSGkaLADWKQKH 1472
Cdd:PRK04863  352 RYQADLE----ELEERLEEQNEVVEEADEQQEENEA-------------------RAEAAEEEVDELKSQ--LADYQQAL 406
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1473 EESQALLDASQKEVQAL--STELLKLKNTYEESIVG-QETLRRENKNLQEEISNLTNQVREGTKNLTEMEKVKKLI---- 1545
Cdd:PRK04863  407 DVQQTRAIQYQQAVQALerAKQLCGLPDLTADNAEDwLEEFQAKEQEATEELLSLEQKLSVAQAAHSQFEQAYQLVrkia 486
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1546 -EEEKTEVQVTLEETEGALErnESKILHFQLELLEAK-AELERKLSEKDEEIENFRRKQQctidSLQSSLDSEAksriEV 1623
Cdd:PRK04863  487 gEVSRSEAWDVARELLRRLR--EQRHLAEQLQQLRMRlSELEQRLRQQQRAERLLAEFCK----RLGKNLDDED----EL 556
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1624 TRLKKKMEEDLNEMELQLSCANRQVSEATKSLGQLQIQIKDLQ------MQLDDS-TQLNSDLKEQVAVAERRNSLLQSE 1696
Cdd:PRK04863  557 EQLQEELEARLESLSESVSEARERRMALRQQLEQLQARIQRLAarapawLAAQDAlARLREQSGEEFEDSQDVTEYMQQL 636
                         410       420
                  ....*....|....*....|....*...
gi 767926067 1697 LEDLRSLQEQTERGRRlSEEELLEATER 1724
Cdd:PRK04863  637 LERERELTVERDELAA-RKQALDEEIER 663
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
980-1195 2.22e-07

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 56.18  E-value: 2.22e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  980 KRTTEHKVKNLTEEVEFLNEdisKLNRAAKVVQEAhQQTLDDLhMEEEKLSSLSKANLKLEQQVDELEGALEQERKARMN 1059
Cdd:COG3206   163 EQNLELRREEARKALEFLEE---QLPELRKELEEA-EAALEEF-RQKNGLVDLSEEAKLLLQQLSELESQLAEARAELAE 237
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1060 CERELHKLEGNLKLNRESMENLESSQ--RHLAEELRKKELELSQMNSKVENEKGLVAQLQKTVKELQTQIKDLKEKLEAE 1137
Cdd:COG3206   238 AEARLAALRAQLGSGPDALPELLQSPviQQLRAQLAELEAELAELSARYTPNHPDVIALRAQIAALRAQLQQEAQRILAS 317
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767926067 1138 -RTTRAKMERERADLTQDLADLNERLEEVGGSSLAQLEITKKQETK---FQKLHRDMEEATL 1195
Cdd:COG3206   318 lEAELEALQAREASLQAQLAQLEARLAELPELEAELRRLEREVEVArelYESLLQRLEEARL 379
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
1082-1250 2.69e-07

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 53.78  E-value: 2.69e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1082 ESSQRHLaEELRKKELELSQMNSKVENEKGLVAQLQKTVKELQTQIKDLKEKLEAERTTRAKMERERADLTQDLADLNER 1161
Cdd:COG1579     3 PEDLRAL-LDLQELDSELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQ 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1162 LEEVggSSLAQLEITKKQETKFQKLHRDMEEATLHFETTSASLKKRHADSLAELEGQVENLQQVKQKLEKDKSDLQLEVD 1241
Cdd:COG1579    82 LGNV--RNNKEYEALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELE 159

                  ....*....
gi 767926067 1242 DLLTRVEQM 1250
Cdd:COG1579   160 ELEAEREEL 168
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
1327-1727 4.02e-07

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 55.34  E-value: 4.02e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1327 LRGQLEKETKSQSALAhaLQKAQRDCdllREQYEEEQEVKAELHRTLSKVNA----------------EMVQWRMKYENN 1390
Cdd:COG3096   274 MRHANERRELSERALE--LRRELFGA---RRQLAEEQYRLVEMARELEELSAresdleqdyqaasdhlNLVQTALRQQEK 348
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1391 VIQRTEDLEdakkELAIRLQEAAEAmgvanARNASLERARHQLQLElgdalsdlgkvrsaAARLDQKQLQSGkaLADWKQ 1470
Cdd:COG3096   349 IERYQEDLE----ELTERLEEQEEV-----VEEAAEQLAEAEARLE--------------AAEEEVDSLKSQ--LADYQQ 403
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1471 KHEESQALLDASQKEVQAL--STELLKLKNTYEESIVG-QETLRRENKNLQEEISNLTNQVREGTKNLTEMEKVKKLIEE 1547
Cdd:COG3096   404 ALDVQQTRAIQYQQAVQALekARALCGLPDLTPENAEDyLAAFRAKEQQATEEVLELEQKLSVADAARRQFEKAYELVCK 483
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1548 EKTEVqvtleETEGALER--------NESKILHFQLELLEAK-AELERKLSEKdeeiENFRRKQQctidSLQSSLDSEAK 1618
Cdd:COG3096   484 IAGEV-----ERSQAWQTarellrryRSQQALAQRLQQLRAQlAELEQRLRQQ----QNAERLLE----EFCQRIGQQLD 550
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1619 SRIEVTRLKKKMEEDLNEMELQLSCANRQVSEATKSLGQLQIQIKDLQMQ----LDDSTQLNSdLKEQVAVAerrnsllq 1694
Cdd:COG3096   551 AAEELEELLAELEAQLEELEEQAAEAVEQRSELRQQLEQLRARIKELAARapawLAAQDALER-LREQSGEA-------- 621
                         410       420       430
                  ....*....|....*....|....*....|....*....
gi 767926067 1695 seLEDLRSLQE------QTERGRRLSEEELLEATERINL 1727
Cdd:COG3096   622 --LADSQEVTAamqqllEREREATVERDELAARKQALES 658
PRK01156 PRK01156
chromosome segregation protein; Provisional
954-1545 4.27e-07

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 55.29  E-value: 4.27e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  954 KLEDECFELKKEIDDLE---TMLVKSEKEKRTTEHKVKNLTEEVEFLNEDISKLNRAAKVVQEAHQQTLDDLHMEEE--- 1027
Cdd:PRK01156  163 SLERNYDKLKDVIDMLRaeiSNIDYLEEKLKSSNLELENIKKQIADDEKSHSITLKEIERLSIEYNNAMDDYNNLKSaln 242
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1028 KLSSLSKANLKLEQQVDELEGALEQErkarmncERELHKLEGnlkLNRESMENLESSQRHLAEELRKKELELSQMNSKVE 1107
Cdd:PRK01156  243 ELSSLEDMKNRYESEIKTAESDLSME-------LEKNNYYKE---LEERHMKIINDPVYKNRNYINDYFKYKNDIENKKQ 312
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1108 NEKGLVAQLQKtvkeLQTQIKDLKEkLEAERTTRAKMERERADLTQDLADLNERlEEVGGSSLAQLEITKKQETKFQKLH 1187
Cdd:PRK01156  313 ILSNIDAEINK----YHAIIKKLSV-LQKDYNDYIKKKSRYDDLNNQILELEGY-EMDYNSYLKSIESLKKKIEEYSKNI 386
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1188 RDM----EEATLHFETTSASLKKRHAD---SLAELEGQVENLQQVKQKLEKDKSDLQLEVDDLLTR----VEQMTRAKAN 1256
Cdd:PRK01156  387 ERMsafiSEILKIQEIDPDAIKKELNEinvKLQDISSKVSSLNQRIRALRENLDELSRNMEMLNGQsvcpVCGTTLGEEK 466
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1257 AEKLCTLYEERLHEATAKLDKVTQLANDLAAQKTKLWSesgeFLRRLEEKEAlinqlsREKSNFTRQIEDLRGQLEKETK 1336
Cdd:PRK01156  467 SNHIINHYNEKKSRLEEKIREIEIEVKDIDEKIVDLKK----RKEYLESEEI------NKSINEYNKIESARADLEDIKI 536
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1337 SQSALAHALQKAQR--------DCDLLREQYEEEQEVKAELhrtlSKVNAEMVQWRmkyENNVIQRTEDLEDAKKELAIR 1408
Cdd:PRK01156  537 KINELKDKHDKYEEiknrykslKLEDLDSKRTSWLNALAVI----SLIDIETNRSR---SNEIKKQLNDLESRLQEIEIG 609
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1409 LQEaaeamgVANARNASLERARHQLQLeLGDALSDLGKVRSAAARLdQKQLQSGKALADWKQKHEESQALLDASQKEVQa 1488
Cdd:PRK01156  610 FPD------DKSYIDKSIREIENEANN-LNNKYNEIQENKILIEKL-RGKIDNYKKQIAEIDSIIPDLKEITSRINDIE- 680
                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 767926067 1489 lsTELLKLKNTYEESIVGQETLRRENKNLQEEISNLTNQVREGTKNLTEMEKVKKLI 1545
Cdd:PRK01156  681 --DNLKKSRKALDDAKANRARLESTIEILRTRINELSDRINDINETLESMKKIKKAI 735
PTZ00121 PTZ00121
MAEBL; Provisional
1261-1946 4.30e-07

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 55.53  E-value: 4.30e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1261 CTLYEERLHEATAKLDKVTQLANDLAAQKTKLWSESGEFLRRLEEKEalINQLSREKSNFTR-----QIEDLRG------ 1329
Cdd:PTZ00121 1000 CVIDKENHFSFTALTANTIDFNQNFNIEKIEELTEYGNNDDVLKEKD--IIDEDIDGNHEGKaeakaHVGQDEGlkpsyk 1077
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1330 ----QLEKETKSQSALAHALQKAQRDCDLLREQYEEEQEVKAELHRTLSKVNAEMVqwRMKYENNVIQRTEDLEDAKK-E 1404
Cdd:PTZ00121 1078 dfdfDAKEDNRADEATEEAFGKAEEAKKTETGKAEEARKAEEAKKKAEDARKAEEA--RKAEDARKAEEARKAEDAKRvE 1155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1405 LAIRLQEAAEAMGVANARNAS-LERARHQLQLELGDALSDLGKVRSA-AARLDQKQLQSGKAL-ADWKQKHEESQALLDA 1481
Cdd:PTZ00121 1156 IARKAEDARKAEEARKAEDAKkAEAARKAEEVRKAEELRKAEDARKAeAARKAEEERKAEEARkAEDAKKAEAVKKAEEA 1235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1482 SQKEVQALSTEllKLKNTYE----ESIVGQETLRRENKNLQEEisnltnqvREGTKNLTEMEKVKKLIEEEKTEVQVTLE 1557
Cdd:PTZ00121 1236 KKDAEEAKKAE--EERNNEEirkfEEARMAHFARRQAAIKAEE--------ARKADELKKAEEKKKADEAKKAEEKKKAD 1305
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1558 ETEG-ALERNESKILHFQLELLEAKAE-LERKLSEKDEEIENFRRKQQCTIDSLQSSLDSEAKSRIEVTRLKKKMEEDLN 1635
Cdd:PTZ00121 1306 EAKKkAEEAKKADEAKKKAEEAKKKADaAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKK 1385
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1636 EMElqlscANRQVSEATKSLGQLQIQIKDLQMQldDSTQLNSDLKEQVAVAERRNSLLQSELEDLRSLQEQTERG--RRL 1713
Cdd:PTZ00121 1386 KAE-----EKKKADEAKKKAEEDKKKADELKKA--AAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAeeAKK 1458
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1714 SEEELLEATERinlfytQNTSLLSQKKKLEADVARMQKEAEEVVQECQNAEEKAKKAAIEAANLSEELKKKQDTIAHLER 1793
Cdd:PTZ00121 1459 AEEAKKKAEEA------KKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEE 1532
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1794 TRENMEQTITDLQKRLAEAEQMALMGSRKQIQKLESRvRELEGELEGEIRRSAEAQRGArrlERCIKELTYQAEEDKKNL 1873
Cdd:PTZ00121 1533 AKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEA-KKAEEDKNMALRKAEEAKKAE---EARIEEVMKLYEEEKKMK 1608
                         650       660       670       680       690       700       710
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767926067 1874 SRMQTQMDKLQLKVQNYKQQVEVAEtqanqylsKYKKQQHELNEVKERAEVAESQVNKLKIKAREFGKKVQEE 1946
Cdd:PTZ00121 1609 AEEAKKAEEAKIKAEELKKAEEEKK--------KVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEED 1673
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
1301-1928 6.59e-07

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 54.84  E-value: 6.59e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1301 RRLEEKEALINQLSREKSNFTRQIEDLRGQLEKETKSQSAlahALQKAQRDCDLLREQYEEEQEVKAELHrtlsKVNAEM 1380
Cdd:pfam12128  276 SRQEERQETSAELNQLLRTLDDQWKEKRDELNGELSAADA---AVAKDRSELEALEDQHGAFLDADIETA----AADQEQ 348
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1381 V-QWRMKYENnVIQRTEDLEDAKKELAIRLQEAAEAMGVANAR-----NASLERARHQLQLELGDALSDLGKVRSAAarl 1454
Cdd:pfam12128  349 LpSWQSELEN-LEERLKALTGKHQDVTAKYNRRRSKIKEQNNRdiagiKDKLAKIREARDRQLAVAEDDLQALESEL--- 424
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1455 dQKQLQSGKA-LADWKQKHEESQALLDASQKEVQALSTELLKLKNTYEESIVGQETLRRENKnlqeEISNLTNQVREGTK 1533
Cdd:pfam12128  425 -REQLEAGKLeFNEEEYRLKSRLGELKLRLNQATATPELLLQLENFDERIERAREEQEAANA----EVERLQSELRQARK 499
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1534 NLTEMEKVKKLIEEEKTEVQVTLEETEGALERNESKILHF----------QLELLEAKAELERklSEKDEEIENFRRKQQ 1603
Cdd:pfam12128  500 RRDQASEALRQASRRLEERQSALDELELQLFPQAGTLLHFlrkeapdweqSIGKVISPELLHR--TDLDPEVWDGSVGGE 577
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1604 CTIDSLQssLDSEAKSRIEVTRLKKKMEEDLNEMELQLSCANRQVSEATKSLGQLQIQIKDLQMQLDDSTQL--NSDLKE 1681
Cdd:pfam12128  578 LNLYGVK--LDLKRIDVPEWAASEEELRERLDKAEEALQSAREKQAAAEEQLVQANGELEKASREETFARTAlkNARLDL 655
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1682 QVAVAERRNSLLQseledlrsLQEQTERGRRLSEEEL--LEATERINLFYTQNTSLLSQKKKLEADVARMQK----EAEE 1755
Cdd:pfam12128  656 RRLFDEKQSEKDK--------KNKALAERKDSANERLnsLEAQLKQLDKKHQAWLEEQKEQKREARTEKQAYwqvvEGAL 727
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1756 VVQECQNAEEKAKKAAIEAANLSE-------ELKKK---QDTIAHLERTRENMEQTITDLQKRLAEAEQMalmgsRKQIQ 1825
Cdd:pfam12128  728 DAQLALLKAAIAARRSGAKAELKAletwykrDLASLgvdPDVIAKLKREIRTLERKIERIAVRRQEVLRY-----FDWYQ 802
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1826 KLESRVRELEGELEGEIRRSAEAQRGarrlercikELTYQAEEDKKNLSRMQTQMDKLQlkvqnyKQQVEVAETqanqyL 1905
Cdd:pfam12128  803 ETWLQRRPRLATQLSNIERAISELQQ---------QLARLIADTKLRRAKLEMERKASE------KQQVRLSEN-----L 862
                          650       660
                   ....*....|....*....|...
gi 767926067  1906 SKYKKQQHELNEVKERAEVAESQ 1928
Cdd:pfam12128  863 RGLRCEMSKLATLKEDANSEQAQ 885
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
864-1163 6.99e-07

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 54.36  E-value: 6.99e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   864 LKEECAQLQKALEKSEFQREELKAKQVSLTQEKndlilQLQAEQETLAnVEEQCEWlikSKIQLEARVKELSERVEEEEE 943
Cdd:pfam17380  301 LRQEKEEKAREVERRRKLEEAEKARQAEMDRQA-----AIYAEQERMA-MEREREL---ERIRQEERKRELERIRQEEIA 371
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   944 INSEltaRGRKLEDECFELKKEIDDLETMLVKSEKEKRTTEHKVKNLTEEveflnedISKLNRAAKVVQEAHQQTLDDLH 1023
Cdd:pfam17380  372 MEIS---RMRELERLQMERQQKNERVRQELEAARKVKILEEERQRKIQQQ-------KVEMEQIRAEQEEARQREVRRLE 441
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1024 MEEEK-LSSLSKANLKLEQQVDELEGALEQERKARMNCERELHKLEGNLKLNRESMEN-LESSQRHLAEELRK-----KE 1096
Cdd:pfam17380  442 EERAReMERVRLEEQERQQQVERLRQQEEERKRKKLELEKEKRDRKRAEEQRRKILEKeLEERKQAMIEEERKrklleKE 521
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767926067  1097 LELSQMNSKVENEKGLVAQLQKTVKELQT--QIKDLKEKLEAERTTRAKMERERADLTQDLADLNERLE 1163
Cdd:pfam17380  522 MEERQKAIYEEERRREAEEERRKQQEMEErrRIQEQMRKATEERSRLEAMEREREMMRQIVESEKARAE 590
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1602-1815 8.11e-07

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 53.61  E-value: 8.11e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1602 QQCTIDSLQSSLDSEAKSRIEVTRLKKKMEEDLNEMELQLSCANRQVSEATKSLGQLQIQIKDLQMQLddstqlnSDLKE 1681
Cdd:COG4942    18 QADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAEL-------AELEK 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1682 QVAVAERRNSLLQSELED-LRSLQEQTERGR---RLSEEELLEATERINLFYTQNTSLLSQKKKLEADVARMQKEAEEVV 1757
Cdd:COG4942    91 EIAELRAELEAQKEELAElLRALYRLGRQPPlalLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELE 170
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 767926067 1758 QECQNAEEKAKKAAIEAANLSEELKKKQDTIAHLERTRENMEQTITDLQKRLAEAEQM 1815
Cdd:COG4942   171 AERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEAL 228
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1117-1368 8.47e-07

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 53.61  E-value: 8.47e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1117 QKTVKELQTQIKDLKEKLEAERTTRAKMERERADLTQDLADLNERLEEVggsslaqleitkkqetkfQKLHRDMEEATLH 1196
Cdd:COG4942    19 ADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAAL------------------ARRIRALEQELAA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1197 FETTSASLKKRHADSLAELEGQVENLQQVKQKLEKDKSDLQLEvddLLTRVEQMTRAKANAEKLCTLYEERLheatAKLD 1276
Cdd:COG4942    81 LEAELAELEKEIAELRAELEAQKEELAELLRALYRLGRQPPLA---LLLSPEDFLDAVRRLQYLKYLAPARR----EQAE 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1277 KVTQLANDLAAQKTKLWSESGEFLRRLEEKEALINQLSREKSnftrQIEDLRGQLEKETKSQSALAHALQKAQRDCDLLR 1356
Cdd:COG4942   154 ELRADLAELAALRAELEAERAELEALLAELEEERAALEALKA----ERQKLLARLEKELAELAAELAELQQEAEELEALI 229
                         250
                  ....*....|..
gi 767926067 1357 EQYEEEQEVKAE 1368
Cdd:COG4942   230 ARLEAEAAAAAE 241
PRK11281 PRK11281
mechanosensitive channel MscK;
1337-1706 9.54e-07

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 54.15  E-value: 9.54e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1337 SQSALAHALQKA--------QRDCDLLREQYEEEQEVKA---ELHRTLS------KVNAEMVQwrmkYENNVIQRTEDLE 1399
Cdd:PRK11281   22 LSSAFARAASNGdlpteadvQAQLDALNKQKLLEAEDKLvqqDLEQTLAlldkidRQKEETEQ----LKQQLAQAPAKLR 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1400 DAKKELAiRLQEAAEAMGVANARNASLErarhQLQLELGDALSDLGKVRSAAARLDQKqlqsgkaLADWKQKHEESQALL 1479
Cdd:PRK11281   98 QAQAELE-ALKDDNDEETRETLSTLSLR----QLESRLAQTLDQLQNAQNDLAEYNSQ-------LVSLQTQPERAQAAL 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1480 DASQKEVQALSTELLKLKntyeesiVGQETLRRENKN-LQEEISNLTNQVREGTKNLtemekvkklieEEKTEVQVTLEE 1558
Cdd:PRK11281  166 YANSQRLQQIRNLLKGGK-------VGGKALRPSQRVlLQAEQALLNAQNDLQRKSL-----------EGNTQLQDLLQK 227
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1559 tegalerneskilhfQLELLEAK-AELERKLSEKDEEIENFRRKQ-QCTIDSLQSSldsEAKSRIEVTRLKKKmEEDLNe 1636
Cdd:PRK11281  228 ---------------QRDYLTARiQRLEHQLQLLQEAINSKRLTLsEKTVQEAQSQ---DEAARIQANPLVAQ-ELEIN- 287
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1637 meLQLSCANRQVSEATKSLGQLQIQIKDlqmQLDDSTQLNSDLKEQVAVAerRNSLLQSeledlRSLQEQ 1706
Cdd:PRK11281  288 --LQLSQRLLKATEKLNTLTQQNLRVKN---WLDRLTQSERNIKEQISVL--KGSLLLS-----RILYQQ 345
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
1096-1340 1.02e-06

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 53.30  E-value: 1.02e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1096 ELELSQMNSKVENEKGLVAQLQKTVKELQTQIKDLKEKLEAERTTRAKMERERADLTQDLADLNERLEEvggsslaqlei 1175
Cdd:COG3883    15 DPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEE----------- 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1176 tkkQETKFQKLHRDMEEATLHFETTSASLKkrhADSLAELEGQVENLQQV----KQKLEKDKSDlQLEVDDLLTRVEQmt 1251
Cdd:COG3883    84 ---RREELGERARALYRSGGSVSYLDVLLG---SESFSDFLDRLSALSKIadadADLLEELKAD-KAELEAKKAELEA-- 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1252 rAKANAEKLCTLYEERLHEATAKLDKVTQLANDLAAQKTKLWSESGEFLRRLEEKEALINQLSREKSNFTRQIEDLRGQL 1331
Cdd:COG3883   155 -KLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAA 233

                  ....*....
gi 767926067 1332 EKETKSQSA 1340
Cdd:COG3883   234 AAAAAAAAA 242
mukB PRK04863
chromosome partition protein MukB;
1067-1927 1.08e-06

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 54.19  E-value: 1.08e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1067 LEGNLKLNRESMENLESSQRHlaEELRKKELELSQMNS-----KVENEK----GLVAQLQKTVKELQTQIKDLKEKLEAE 1137
Cdd:PRK04863  235 MEAALRENRMTLEAIRVTQSD--RDLFKHLITESTNYVaadymRHANERrvhlEEALELRRELYTSRRQLAAEQYRLVEM 312
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1138 RTTRAKMERERADLTQDLADLNERLEEVGGSSLAQLEITKKQEtkfqklhrDMEEATLHFETtSASLKKRHADSLAELEG 1217
Cdd:PRK04863  313 ARELAELNEAESDLEQDYQAASDHLNLVQTALRQQEKIERYQA--------DLEELEERLEE-QNEVVEEADEQQEENEA 383
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1218 QVENLQQVKQKLEKDKSDLQLEVDDLLTRVEQMTRAKA---NAEKLCTL-------YEERLHEATAKLDKVTQLANDLA- 1286
Cdd:PRK04863  384 RAEAAEEEVDELKSQLADYQQALDVQQTRAIQYQQAVQaleRAKQLCGLpdltadnAEDWLEEFQAKEQEATEELLSLEq 463
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1287 ------------AQKTKL-------------WSESGEFLRRLEEKEALINQLSREKsnftRQIEDLRGQLEKETKSQSAL 1341
Cdd:PRK04863  464 klsvaqaahsqfEQAYQLvrkiagevsrseaWDVARELLRRLREQRHLAEQLQQLR----MRLSELEQRLRQQQRAERLL 539
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1342 AHALQKAQRDCDL--LREQYEEEQEVKAElhrTLSKVNAEMVQWRMkyennviqrteDLEDAKKELAIRLQeaaeamgva 1419
Cdd:PRK04863  540 AEFCKRLGKNLDDedELEQLQEELEARLE---SLSESVSEARERRM-----------ALRQQLEQLQARIQ--------- 596
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1420 naRNASLERARHQLQlelgDALSDLGKvrsaaarldqkqlQSGKALADwkqkheesqalldaSQKEVQALSTELLKLKNT 1499
Cdd:PRK04863  597 --RLAARAPAWLAAQ----DALARLRE-------------QSGEEFED--------------SQDVTEYMQQLLEREREL 643
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1500 YEESivgqETLRRENKNLQEEISNLTNqvREGTknltEMEKVKKLIE----EEKTEV--QVTLEE---TEGALERNESKI 1570
Cdd:PRK04863  644 TVER----DELAARKQALDEEIERLSQ--PGGS----EDPRLNALAErfggVLLSEIydDVSLEDapyFSALYGPARHAI 713
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1571 LHFQLELLEAK----------------------------AELER----KLSEKDEEIENF-------RRKQQCTIDSLQS 1611
Cdd:PRK04863  714 VVPDLSDAAEQlagledcpedlyliegdpdsfddsvfsvEELEKavvvKIADRQWRYSRFpevplfgRAAREKRIEQLRA 793
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1612 SLDSE----AKSRIEVTRLKKkMEEDLNEM-------------ELQLSCANRQVSEATKSLGQLQIQIKDLQMQLDdstq 1674
Cdd:PRK04863  794 EREELaeryATLSFDVQKLQR-LHQAFSRFigshlavafeadpEAELRQLNRRRVELERALADHESQEQQQRSQLE---- 868
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1675 lnsDLKEQVavaerrnSLLQsELEDLRSLQEQTERGRRLSE-EELLEATERINLFYTQNTSLLSQKKKLEADVARMQKEA 1753
Cdd:PRK04863  869 ---QAKEGL-------SALN-RLLPRLNLLADETLADRVEEiREQLDEAEEAKRFVQQHGNALAQLEPIVSVLQSDPEQF 937
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1754 EEVVQECQNAEEKAKKAAIEAANLSEELKKK-----QDTIAHLERTRENMEQtitdLQKRLAEAEQMALMgSRKQIQKLE 1828
Cdd:PRK04863  938 EQLKQDYQQAQQTQRDAKQQAFALTEVVQRRahfsyEDAAEMLAKNSDLNEK----LRQRLEQAEQERTR-AREQLRQAQ 1012
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1829 SRVRELEGELEGEIRRSAEAQRGARRLERCIKELTYQAEEDKKnlSRMQTQMDKLQlkvqnykQQVEVAETQANQYLSKY 1908
Cdd:PRK04863 1013 AQLAQYNQVLASLKSSYDAKRQMLQELKQELQDLGVPADSGAE--ERARARRDELH-------ARLSANRSRRNQLEKQL 1083
                         970
                  ....*....|....*....
gi 767926067 1909 KKQQHELNEVKERAEVAES 1927
Cdd:PRK04863 1084 TFCEAEMDNLTKKLRKLER 1102
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
861-1215 1.24e-06

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 53.77  E-value: 1.24e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  861 VAGLKEECAQLQKALEKSEFQREELKAKQVSLTQEKNDL--ILQLQAEQETLANVEEQCEwlikskiQLEARVKELSERv 938
Cdd:COG4913   612 LAALEAELAELEEELAEAEERLEALEAELDALQERREALqrLAEYSWDEIDVASAEREIA-------ELEAELERLDAS- 683
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  939 eeeeeiNSELTARGRKLEdecfELKKEIDDLETMLVKSEKEKRTTEHKVKNLTEEVEFLNEdisKLNRAAKVVQEAHQQT 1018
Cdd:COG4913   684 ------SDDLAALEEQLE----ELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQD---RLEAAEDLARLELRAL 750
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1019 LDDLHMEEEKLSSLSKANLKLEQQVDELEGALEQERKARMNCERELHKLEGNLKLN-RESMENLESSQRHLaEELRKKEL 1097
Cdd:COG4913   751 LEERFAAALGDAVERELRENLEERIDALRARLNRAEEELERAMRAFNREWPAETADlDADLESLPEYLALL-DRLEEDGL 829
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1098 ElsqmnskvenekglvaqlqktvkELQTQIKDLKEKLEAERTTR--AKMERERADLTQDLADLNERLEEV---GGSSLaQ 1172
Cdd:COG4913   830 P-----------------------EYEERFKELLNENSIEFVADllSKLRRAIREIKERIDPLNDSLKRIpfgPGRYL-R 885
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 767926067 1173 LEITKKQETKFQKLHRDMEEATLHFETTSASLKKRHADSLAEL 1215
Cdd:COG4913   886 LEARPRPDPEVREFRQELRAVTSGASLFDEELSEARFAALKRL 928
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
974-1172 1.47e-06

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 52.91  E-value: 1.47e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  974 VKSEKEKRTTEHKVKNLTEEVEFLNEDISKLNRAAKVVQEAHQQTLDDLHMEEEKLSSLSKANLKLEQQVDELEGALEQE 1053
Cdd:COG3883    12 AFADPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGER 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1054 RKARMNCERELHKLE-----GNLK--LNR-ESMENLESSQRHLAEELRKKELELSQMNSKVENEKG----LVAQLQKTVK 1121
Cdd:COG3883    92 ARALYRSGGSVSYLDvllgsESFSdfLDRlSALSKIADADADLLEELKADKAELEAKKAELEAKLAeleaLKAELEAAKA 171
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 767926067 1122 ELQTQIKDLKEKLEAERTTRAKMERERADLTQDLADLNERLEEVGGSSLAQ 1172
Cdd:COG3883   172 ELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAA 222
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
1287-1946 1.57e-06

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 53.19  E-value: 1.57e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1287 AQKTKLWSESGEFLRR-----LEEKEALINQLSREKSNFTRQIEDLRGQLEKETKSQSALAHALQKAQRDCDLLRE---- 1357
Cdd:pfam05483   87 AEKIKKWKVSIEAELKqkenkLQENRKIIEAQRKAIQELQFENEKVSLKLEEEIQENKDLIKENNATRHLCNLLKEtcar 166
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1358 ------QYEEEQEVKAELHRTLSKVNAEMVqwrMKYENNVIQRtedlEDAKKELAIRLQEAAEAMG-VANARNASLERAR 1430
Cdd:pfam05483  167 saektkKYEYEREETRQVYMDLNNNIEKMI---LAFEELRVQA----ENARLEMHFKLKEDHEKIQhLEEEYKKEINDKE 239
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1431 HQLQLELGDALSDLGKVRSAAARLDQKQLQSGKALADWKQKHEEsqalLDASQKEVQALSTELLKLKNTYEESIVGQETL 1510
Cdd:pfam05483  240 KQVSLLLIQITEKENKMKDLTFLLEESRDKANQLEEKTKLQDEN----LKELIEKKDHLTKELEDIKMSLQRSMSTQKAL 315
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1511 RRENKNLQEEISNLTNQVREGTKNLTEMEKVKKLIEEEKTEVQVTLEE----TEGALERNESKILHFQLELLEAKAELEr 1586
Cdd:pfam05483  316 EEDLQIATKTICQLTEEKEAQMEELNKAKAAHSFVVTEFEATTCSLEEllrtEQQRLEKNEDQLKIITMELQKKSSELE- 394
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1587 klsekdeEIENFRRKQQCTIDSLQSSLdSEAKSRIEVTRLKKKMEEDLNEMELQLscanrqvseatksLGQLQIQIKDLQ 1666
Cdd:pfam05483  395 -------EMTKFKNNKEVELEELKKIL-AEDEKLLDEKKQFEKIAEELKGKEQEL-------------IFLLQAREKEIH 453
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1667 mqlddstqlnsDLKEQVAVAERRNSLLQSELEDLRSLQEQtergRRLSEEELLEATERI---NLFYTQNTS-LLSQKKKL 1742
Cdd:pfam05483  454 -----------DLEIQLTAIKTSEEHYLKEVEDLKTELEK----EKLKNIELTAHCDKLlleNKELTQEASdMTLELKKH 518
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1743 EADVARMQKEAEEVVQECQNAEEKAKKAAIEAANLSEELKKKQDTI-AHLERTRENmeqtitdlqkrlAEAEQMALMGSR 1821
Cdd:pfam05483  519 QEDIINCKKQEERMLKQIENLEEKEMNLRDELESVREEFIQKGDEVkCKLDKSEEN------------ARSIEYEVLKKE 586
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1822 KQIQKLESRVRELEGELEGEIRRSAEAQRGARRLERcikeltyQAEEDKKNLSRMQTQMDKLQLKVQNYKQQVEVAETQA 1901
Cdd:pfam05483  587 KQMKILENKCNNLKKQIENKNKNIEELHQENKALKK-------KGSAENKQLNAYEIKVNKLELELASAKQKFEEIIDNY 659
                          650       660       670       680
                   ....*....|....*....|....*....|....*....|....*
gi 767926067  1902 NQYLSKYKKQQHELNEVKERAEVAESQVNKLKikaREFGKKVQEE 1946
Cdd:pfam05483  660 QKEIEDKKISEEKLLEEVEKAKAIADEAVKLQ---KEIDKRCQHK 701
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1534-1715 2.08e-06

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 52.71  E-value: 2.08e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1534 NLTEMEKVKKLIEEEKTEVQVTLEETEGALE--RNESKILHFQLE---LLEAKAELERKLSEKDEEIENFRRKqqctIDS 1608
Cdd:COG3206   169 RREEARKALEFLEEQLPELRKELEEAEAALEefRQKNGLVDLSEEaklLLQQLSELESQLAEARAELAEAEAR----LAA 244
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1609 LQSSLDS--EAKSRIEVTRLKKKMEEDLNEMELQLSCANRQVSEATKSLGQLQIQIKDLQMQLDDSTQ-LNSDLKEQVAV 1685
Cdd:COG3206   245 LRAQLGSgpDALPELLQSPVIQQLRAQLAELEAELAELSARYTPNHPDVIALRAQIAALRAQLQQEAQrILASLEAELEA 324
                         170       180       190
                  ....*....|....*....|....*....|.
gi 767926067 1686 AERRNSLLQSELEDLRS-LQEQTERGRRLSE 1715
Cdd:COG3206   325 LQAREASLQAQLAQLEArLAELPELEAELRR 355
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
926-1164 2.35e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 52.07  E-value: 2.35e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  926 QLEARVKelserveeeeeinsELTARGRKLEDECFELKKEIDDLETMLVKSEKEKRTTEHKVKNLTEEVEFLNEDISKLN 1005
Cdd:COG4942    24 EAEAELE--------------QLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELE 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1006 RAAKVVQEahqqtldDLHMEEEKLSSLSKANLKLEQQvDELEGALEQERKARMncERELHKLEGNLKLNRESMENLESSQ 1085
Cdd:COG4942    90 KEIAELRA-------ELEAQKEELAELLRALYRLGRQ-PPLALLLSPEDFLDA--VRRLQYLKYLAPARREQAEELRADL 159
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767926067 1086 RHLAEELRKKELELSQMNSKVENEKGLVAQLQKTVKELQTQIKDLKEKLEAERTTRAKMERERADLTQDLADLNERLEE 1164
Cdd:COG4942   160 AELAALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAA 238
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1210-1600 2.56e-06

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 52.46  E-value: 2.56e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1210 DSLAELEGQVENLQQVKQKLEKDKSDLQLEVDDLLTRVEQMTRAKANAEklctlYEERLHEATAKLDkvtqlandlaaqk 1289
Cdd:COG4717    81 KEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQLLP-----LYQELEALEAELA------------- 142
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1290 tklwsESGEFLRRLEEKEALINQLSREKSNFTRQIEDLRGQLEKETKSQSALAH-ALQKAQRDCDLLREQYEEEQEVKAE 1368
Cdd:COG4717   143 -----ELPERLEELEERLEELRELEEELEELEAELAELQEELEELLEQLSLATEeELQDLAEELEELQQRLAELEEELEE 217
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1369 LHRTLSKVNAEMVQWRMKYENNVIQRT----------------------------------------------EDLEDAK 1402
Cdd:COG4717   218 AQEELEELEEELEQLENELEAAALEERlkearlllliaaallallglggsllsliltiagvlflvlgllallfLLLAREK 297
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1403 KELAIRLQEAAEAMGVANARNASLERARHQLQLELGDALSDLGKVRSAAARLDQKQLQsgkaladwkQKHEESQALLDAS 1482
Cdd:COG4717   298 ASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLRE---------AEELEEELQLEEL 368
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1483 QKEVQALsteLLKLKNTYEESIVGQETLRRENKNLQEEISNLTNQVREGTKNLTEMEKV--KKLIEEEKTEVQVTLEETE 1560
Cdd:COG4717   369 EQEIAAL---LAEAGVEDEEELRAALEQAEEYQELKEELEELEEQLEELLGELEELLEAldEEELEEELEELEEELEELE 445
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|..
gi 767926067 1561 GALERNESKI--LHFQLELLEAKAELERKLSEKDEEIENFRR 1600
Cdd:COG4717   446 EELEELREELaeLEAELEQLEEDGELAELLQELEELKAELRE 487
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
1446-1933 3.24e-06

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 52.28  E-value: 3.24e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1446 KVRSAAARLDQKQLQSGKALADWKQKHEESQALLDASQKEVQALSTELLKLKNTyEESIVGQETLRRENKNLQEEISNLT 1525
Cdd:TIGR00618  188 KKKSLHGKAELLTLRSQLLTLCTPCMPDTYHERKQVLEKELKHLREALQQTQQS-HAYLTQKREAQEEQLKKQQLLKQLR 266
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1526 NQVREGTKNLTEMEKVKKLIEEEKTEVQVTLEETegALERNESKILHFQLELLEAKAELERKLSEKDEEIENfRRKQQCT 1605
Cdd:TIGR00618  267 ARIEELRAQEAVLEETQERINRARKAAPLAAHIK--AVTQIEQQAQRIHTELQSKMRSRAKLLMKRAAHVKQ-QSSIEEQ 343
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1606 IDSLQSSLDSEAKSRIEVTRLKKKMEEDLNEMEL-----QLSCANRQVSEATKSLGQLQIQIKDLQMQLDDSTQLNSDLK 1680
Cdd:TIGR00618  344 RRLLQTLHSQEIHIRDAHEVATSIREISCQQHTLtqhihTLQQQKTTLTQKLQSLCKELDILQREQATIDTRTSAFRDLQ 423
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1681 EQVAVAERRNSLLQSELEDLRSLQEQTERGRRLSEEELLEATERinlfYTQNTSLLSQKKKLEADVARMQKEAEEVVQEC 1760
Cdd:TIGR00618  424 GQLAHAKKQQELQQRYAELCAAAITCTAQCEKLEKIHLQESAQS----LKEREQQLQTKEQIHLQETRKKAVVLARLLEL 499
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1761 QNAE---EKAKKAAIEAANLSEELKKKQDTIAHLERTRENMEQTITDLqkrlaEAEQMALMGSRKQIQKLESRVRELEGE 1837
Cdd:TIGR00618  500 QEEPcplCGSCIHPNPARQDIDNPGPLTRRMQRGEQTYAQLETSEEDV-----YHQLTSERKQRASLKEQMQEIQQSFSI 574
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1838 LEGEIRRSAEAQRGARRL-ERCIKELTYQAEEDKKNLSRMQTQMDKLQLKVQNYKQQVEVAETQANQYLSKYKKQQHELN 1916
Cdd:TIGR00618  575 LTQCDNRSKEDIPNLQNItVRLQDLTEKLSEAEDMLACEQHALLRKLQPEQDLQDVRLHLQQCSQELALKLTALHALQLT 654
                          490
                   ....*....|....*..
gi 767926067  1917 EVKERAEVAESQVNKLK 1933
Cdd:TIGR00618  655 LTQERVREHALSIRVLP 671
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
1400-1932 3.64e-06

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 52.13  E-value: 3.64e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1400 DAKKELAIRLQEAAEAMGVANARNASLERARHqLQLELGDALSDLGKVRSAAARLDQKQLQSGKALADWKQKHEESQALL 1479
Cdd:pfam10174   40 ELKKERALRKEEAARISVLKEQYRVTQEENQH-LQLTIQALQDELRAQRDLNQLLQQDFTTSPVDGEDKFSTPELTEENF 118
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1480 DASQKEVQALSTELLKLKNTYEE---SIVGQ--------ETLRRENKNLQ---------EEISNLTNQVREGTKNLTEME 1539
Cdd:pfam10174  119 RRLQSEHERQAKELFLLRKTLEEmelRIETQkqtlgardESIKKLLEMLQskglpkksgEEDWERTRRIAEAEMQLGHLE 198
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1540 KVKKLIEEEKTEVQVTLE-ETEGALERNESKILHFQLELLEAK-AELERKLSEKDEEIEnfrrkqqctidSLQSSLDSEA 1617
Cdd:pfam10174  199 VLLDQKEKENIHLREELHrRNQLQPDPAKTKALQTVIEMKDTKiSSLERNIRDLEDEVQ-----------MLKTNGLLHT 267
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1618 KSRievtrlkkkmEEDLNEMELQLSCAN---RQVSEATKSLGQLQIQIKDLQMQLDDSTQLNSD-------LKEQVAVAE 1687
Cdd:pfam10174  268 EDR----------EEEIKQMEVYKSHSKfmkNKIDQLKQELSKKESELLALQTKLETLTNQNSDckqhievLKESLTAKE 337
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1688 RRNSLLQSELEDLRS--------LQEQTERGRRLSEE------------ELLEATER-INLFYTQNTSLLSQKKkleaDV 1746
Cdd:pfam10174  338 QRAAILQTEVDALRLrleekesfLNKKTKQLQDLTEEkstlageirdlkDMLDVKERkINVLQKKIENLQEQLR----DK 413
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1747 ARMQKEAEEVVQECQnaeekakkaaIEAANLSEELKKKQDTIAHLERTRENM-EQTITDLQKRLAEAEQMalmgsRKQIQ 1825
Cdd:pfam10174  414 DKQLAGLKERVKSLQ----------TDSSNTDTALTTLEEALSEKERIIERLkEQREREDRERLEELESL-----KKENK 478
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1826 KLESRVRELEGELEG--------EIRRSAEAQRGARRLERcIKELTYQAEEDKKNLSRMQTQMDKlqlkvqnyKQQVEVA 1897
Cdd:pfam10174  479 DLKEKVSALQPELTEkesslidlKEHASSLASSGLKKDSK-LKSLEIAVEQKKEECSKLENQLKK--------AHNAEEA 549
                          570       580       590
                   ....*....|....*....|....*....|....*
gi 767926067  1898 ETQANQYLSKYKKQQHELNEVKERAEVAESQVNKL 1932
Cdd:pfam10174  550 VRTNPEINDRIRLLEQEVARYKEESGKAQAEVERL 584
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
1424-1925 3.77e-06

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 52.13  E-value: 3.77e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1424 ASLERARHQLQLELgDALSDLGKVRSAAARLDQKQLQSGKALADW-KQKHEESQALLDASQKEVQALSTELLKLKNTYEE 1502
Cdd:pfam10174  243 SSLERNIRDLEDEV-QMLKTNGLLHTEDREEEIKQMEVYKSHSKFmKNKIDQLKQELSKKESELLALQTKLETLTNQNSD 321
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1503 SI----VGQETLRRENKN---LQEEISNLTNQVREGTKNLTEMEKVKKLIEEEKTEVQVTLEETEGALERNESKILhfql 1575
Cdd:pfam10174  322 CKqhieVLKESLTAKEQRaaiLQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKSTLAGEIRDLKDMLDVKERKIN---- 397
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1576 eLLEAKAE-LERKLSEKDEEIENFRRKQQ------CTIDSLQSSLDsEA---KSRIeVTRLKKKME-EDLNEMElqlsca 1644
Cdd:pfam10174  398 -VLQKKIEnLQEQLRDKDKQLAGLKERVKslqtdsSNTDTALTTLE-EAlseKERI-IERLKEQRErEDRERLE------ 468
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1645 nrQVSEATKSLGQLQIQIKDLQMQLDDSTQLNSDLKEQVAVAERRNSLLQSELEDLR-SLQEQTERGRRLseEELLEATE 1723
Cdd:pfam10174  469 --ELESLKKENKDLKEKVSALQPELTEKESSLIDLKEHASSLASSGLKKDSKLKSLEiAVEQKKEECSKL--ENQLKKAH 544
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1724 RINLFYTQNTSLLSQKKKLEADVARMQKEAeevvqecqnaeekakkaaieaanlseelKKKQDTIAHLERTRENMEQTIT 1803
Cdd:pfam10174  545 NAEEAVRTNPEINDRIRLLEQEVARYKEES----------------------------GKAQAEVERLLGILREVENEKN 596
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1804 DLQKRLAEAEQMALmgsrKQIQKLESRVRELEGELEGEIRRSAEAQRGARRLERCIKE--LTYQAEEDKKNLSRMQTQMD 1881
Cdd:pfam10174  597 DKDKKIAELESLTL----RQMKEQNKKVANIKHGQQEMKKKGAQLLEEARRREDNLADnsQQLQLEELMGALEKTRQELD 672
                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....
gi 767926067  1882 KLQLKVQNYKQQVEVAETQANQYLSKYKKQQHELNEVKERAEVA 1925
Cdd:pfam10174  673 ATKARLSSTQQSLAEKDGHLTNLRAERRKQLEEILEMKQEALLA 716
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1238-1863 4.08e-06

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 52.22  E-value: 4.08e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1238 LEVDDLLTRVEQMtraKANAEKLctlyeERLHEATAKL-DKVTQLA--NDLAAQKTKLWsesgeflRRLEEKEALINQLS 1314
Cdd:COG4913   218 LEEPDTFEAADAL---VEHFDDL-----ERAHEALEDArEQIELLEpiRELAERYAAAR-------ERLAELEYLRAALR 282
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1315 REKSnfTRQIEDLRGQLEketksqsALAHALQKAQRDCDLLREQYEEEQEVKAELHRTLSKVNaemvqwrmkyennviqr 1394
Cdd:COG4913   283 LWFA--QRRLELLEAELE-------ELRAELARLEAELERLEARLDALREELDELEAQIRGNG----------------- 336
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1395 TEDLEDAKKELAirlqeaaeamgvanarnaslerarhQLQLELGDALSDLGKVRSAAARLDQKQLQSGKALAdwkqkhee 1474
Cdd:COG4913   337 GDRLEQLEREIE-------------------------RLERELEERERRRARLEALLAALGLPLPASAEEFA-------- 383
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1475 sqALLDASQKEVQALSTELLKLKNTYEESIVGQETLRRENKNLQEEISNLtnqvREGTKNLT-EMEKVKKLIEEE--KTE 1551
Cdd:COG4913   384 --ALRAEAAALLEALEEELEALEEALAEAEAALRDLRRELRELEAEIASL----ERRKSNIPaRLLALRDALAEAlgLDE 457
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1552 ---------VQVTLEET--EGALERneskILH-FQLELLeAKAELERKLSEKdeeIENFRRKQQCTIDSLQSSLDSEAKS 1619
Cdd:COG4913   458 aelpfvgelIEVRPEEErwRGAIER----VLGgFALTLL-VPPEHYAAALRW---VNRLHLRGRLVYERVRTGLPDPERP 529
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1620 RIEVTRLKKKMEEDLN------EMEL-------------QLSCANRQVSEA--TKSLGQLQiqikdlqmQLDDSTQLNSD 1678
Cdd:COG4913   530 RLDPDSLAGKLDFKPHpfrawlEAELgrrfdyvcvdspeELRRHPRAITRAgqVKGNGTRH--------EKDDRRRIRSR 601
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1679 -------------LKEQVAVAERRNSLLQSELEDLRSLQEQTERGRRLSEEELLEATERINLFYTQNT--SLLSQKKKLE 1743
Cdd:COG4913   602 yvlgfdnraklaaLEAELAELEEELAEAEERLEALEAELDALQERREALQRLAEYSWDEIDVASAEREiaELEAELERLD 681
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1744 A---DVARMQKEAEEVVQEcqnaeekakkaaieAANLSEELKKKQDTIAHLERTRENMEQTITDLQKRLAEAEQMALMGS 1820
Cdd:COG4913   682 AssdDLAALEEQLEELEAE--------------LEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLEL 747
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|....*.
gi 767926067 1821 RkqiQKLESRVRELEG-ELEGEIRRSAEAQRGA--RRLERCIKELT 1863
Cdd:COG4913   748 R---ALLEERFAAALGdAVERELRENLEERIDAlrARLNRAEEELE 790
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1582-1814 4.43e-06

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 51.94  E-value: 4.43e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1582 AELERKLSEKDEEIENFRRKQQctidslqsSLDSEAKSRIEVTRLKKkMEEDLNEMELQLSCANRQVSEATKSLGQLQIQ 1661
Cdd:COG3206   185 PELRKELEEAEAALEEFRQKNG--------LVDLSEEAKLLLQQLSE-LESQLAEARAELAEAEARLAALRAQLGSGPDA 255
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1662 IKDLQmqlddSTQLNSDLKEQVAVAERRNSLLQSEL----EDLRSLQEQTERGRRLSEEELLEATERINlfyTQNTSLLS 1737
Cdd:COG3206   256 LPELL-----QSPVIQQLRAQLAELEAELAELSARYtpnhPDVIALRAQIAALRAQLQQEAQRILASLE---AELEALQA 327
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767926067 1738 QKKKLEADVARMQKEAEEvvqecqnaeekakkaaieaanlseeLKKKQDTIAHLERTRENMEQTITDLQKRLAEAEQ 1814
Cdd:COG3206   328 REASLQAQLAQLEARLAE-------------------------LPELEAELRRLEREVEVARELYESLLQRLEEARL 379
Crescentin pfam19220
Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament ...
1020-1308 5.44e-06

Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament proteins, named crescentin, whose cytoskeletal function is required for the vibrioid and helical shapes of Caulobacter crescentus. Without crescentin, the cells adopt a straight-rod morphology. Crescentin has characteriztic features of IF proteins including the ability to assemble into filaments in vitro without energy or cofactor requirements. In vivo, crescentin forms a helical structure that colocalizes with the inner cell curvatures beneath the cytoplasmic membrane.


Pssm-ID: 437057 [Multi-domain]  Cd Length: 401  Bit Score: 50.84  E-value: 5.44e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1020 DDLHMEEEKLSSLSKANLKLEQQVDELEGALEQERKARMNCERELHKLEGNLKLNRESMENLESSQRHLAEELRKKELEL 1099
Cdd:pfam19220   27 ADFSQLIEPIEAILRELPQAKSRLLELEALLAQERAAYGKLRRELAGLTRRLSAAEGELEELVARLAKLEAALREAEAAK 106
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1100 SQMNSKVENEKGLVAQLQKTVKELQTQIKDLKEKLEAERTTRAKMERERADLTQDLADLNERLEEVGGSSLAQLEITKKQ 1179
Cdd:pfam19220  107 EELRIELRDKTAQAEALERQLAAETEQNRALEEENKALREEAQAAEKALQRAEGELATARERLALLEQENRRLQALSEEQ 186
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1180 ETKFQKLHRDMEEatlhFETTSASLKKRhadsLAELEGQVENLQQVKQK----LEKDKSDLQLEVDDLLTRVEQMTRAKA 1255
Cdd:pfam19220  187 AAELAELTRRLAE----LETQLDATRAR----LRALEGQLAAEQAERERaeaqLEEAVEAHRAERASLRMKLEALTARAA 258
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|...
gi 767926067  1256 NAEKLCTLYEERLHEATAKLDKVTQLANDLAAQKTKLwsesgefLRRLEEKEA 1308
Cdd:pfam19220  259 ATEQLLAEARNQLRDRDEAIRAAERRLKEASIERDTL-------ERRLAGLEA 304
Motor_domain cd01363
Myosin and Kinesin motor domain; Myosin and Kinesin motor domain. These ATPases belong to the ...
596-687 5.82e-06

Myosin and Kinesin motor domain; Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes. Some of the names do not match with what is given in the sequence list. This is because they are based on the current nomenclature by Kollmar/Sebe-Pedros.


Pssm-ID: 276814 [Multi-domain]  Cd Length: 170  Bit Score: 48.50  E-value: 5.82e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  596 GVVPY---NISGWLEKNKDLLNETVVAVFQKSSNRLLAslfenymstdsAIPFGEKKR-----------KKGASFQTVAS 661
Cdd:cd01363    71 GVIPYlasVAFNGINKGETEGWVYLTEITVTLEDQILQ-----------ANPILEAFGnakttrnenssRFGKFIEILLD 139
                          90       100       110
                  ....*....|....*....|....*....|.
gi 767926067  662 L-----HKENLNKLMTNLKSTAPHFVRCINP 687
Cdd:cd01363   140 IagfeiINESLNTLMNVLRATRPHFVRCISP 170
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1470-1689 6.24e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 50.53  E-value: 6.24e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1470 QKHEESQALLDASQKEVQALSTELLKLKNTyeesivgQETLRRENKNLQEEISNLTNQVREGTKNLTEMEKVKKLIEEEK 1549
Cdd:COG4942    20 DAAAEAEAELEQLQQEIAELEKELAALKKE-------EKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEI 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1550 TEVQVTLEETEGALERNESKI----LHFQLELL---EAKAELERKLsEKDEEIENFRRKQqctIDSLQSSLDSEAKSRIE 1622
Cdd:COG4942    93 AELRAELEAQKEELAELLRALyrlgRQPPLALLlspEDFLDAVRRL-QYLKYLAPARREQ---AEELRADLAELAALRAE 168
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767926067 1623 VTRLKKKMEEDLNEMELQLSCANRQVSEATKSLGQLQIQIKDLQMQLDDSTQLNSDLKEQVAVAERR 1689
Cdd:COG4942   169 LEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAE 235
HCR pfam07111
Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha ...
1130-1893 8.17e-06

Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha helical coiled-coil rod HCR proteins. The function of HCR is unknown but it has been implicated in psoriasis in humans and is thought to affect keratinocyte proliferation.


Pssm-ID: 284517 [Multi-domain]  Cd Length: 749  Bit Score: 50.91  E-value: 8.17e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1130 LKEKLEAERTTRAKMERERADLTQDLADLNERLEEVGGSSLAQ-LEITKKQetkFQKLHRDMEEATLHFETTsaslkkrh 1208
Cdd:pfam07111   21 LERRLDTQRPTVTMWEQDVSGDGQGPGRRGRSLELEGSQALSQqAELISRQ---LQELRRLEEEVRLLRETS-------- 89
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1209 adslaelegqvenLQQvKQKLEKDKSDLqlevdDLLTRVEQMTRAKAnaeklctlyeERLHEATAKLDKVTQlanDLAAQ 1288
Cdd:pfam07111   90 -------------LQQ-KMRLEAQAMEL-----DALAVAEKAGQAEA----------EGLRAALAGAEMVRK---NLEEG 137
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1289 KTKlwsESGEFLRRLEEKEALINQLSREK-SNFTRQIEDLRGQLEKETKSQSALAHALQKAQRDCDLLREQY---EEEQE 1364
Cdd:pfam07111  138 SQR---ELEEIQRLHQEQLSSLTQAHEEAlSSLTSKAEGLEKSLNSLETKRAGEAKQLAEAQKEAELLRKQLsktQEELE 214
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1365 VKAELHRTLSKVNAEMVQWRMKYENNVIQRTEDLEDAK--KELAIRLQEAAEAMGVanaRNASLErarHQLQLElgdals 1442
Cdd:pfam07111  215 AQVTLVESLRKYVGEQVPPEVHSQTWELERQELLDTMQhlQEDRADLQATVELLQV---RVQSLT---HMLALQ------ 282
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1443 dlgkvrsaAARLDQKQLQSGKALADWKQKheeSQALLDASQKEVQALSTELLKLKNTYEESIvgqetlrrenKNLQEEIS 1522
Cdd:pfam07111  283 --------EEELTRKIQPSDSLEPEFPKK---CRSLLNRWREKVFALMVQLKAQDLEHRDSV----------KQLRGQVA 341
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1523 NLTNQVregTKNLTEMEKVKKLIEEEKTEVQVtleetegalERNESKILHFQL-ELLEAKAELERKLSEKDEEIENFRRK 1601
Cdd:pfam07111  342 ELQEQV---TSQSQEQAILQRALQDKAAEVEV---------ERMSAKGLQMELsRAQEARRRQQQQTASAEEQLKFVVNA 409
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1602 QQCTIDSLQSSLDSEAKSRIEVTRLKKKMEEDLNEMELQLSCANRQVseatkSLGQLQIQIKDLQmqlDDSTQLNSDLKE 1681
Cdd:pfam07111  410 MSSTQIWLETTMTRVEQAVARIPSLSNRLSYAVRKVHTIKGLMARKV-----ALAQLRQESCPPP---PPAPPVDADLSL 481
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1682 QVAVAERRNSLLQSELE-DLRSLQEQTERGRRLSEEELLEaterinlfytqntsLLSQKKKLEADVARMQKEAEEVVQEC 1760
Cdd:pfam07111  482 ELEQLREERNRLDAELQlSAHLIQQEVGRAREQGEAERQQ--------------LSEVAQQLEQELQRAQESLASVGQQL 547
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1761 QNAEEKAKKAAIEAANLSEELKKKQDTI--AHLERTRE---NMEQTITDLQKRLAEA--EQMALMGSRKQIQK--LESRV 1831
Cdd:pfam07111  548 EVARQGQQESTEEAASLRQELTQQQEIYgqALQEKVAEvetRLREQLSDTKRRLNEArrEQAKAVVSLRQIQHraTQEKE 627
                          730       740       750       760       770       780
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767926067  1832 RELEGELEGEIRRSAEAQRGARRLercikeltyQAEEDKKNLSRMQTQMDKLqlkVQNYKQQ 1893
Cdd:pfam07111  628 RNQELRRLQDEARKEEGQRLARRV---------QELERDKNLMLATLQQEGL---LSRYKQQ 677
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1265-1488 9.48e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 50.15  E-value: 9.48e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1265 EERLHEATAKLDKVTQLANDLAAQKTKLWSESGEFLRRLEEKEALINQLSREKSNFTRQIEDLRGQLEKETKSQSALAHA 1344
Cdd:COG4942    26 EAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQKEE 105
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1345 LQKaqrdcdLLREQYEEEQEVKAELhrTLSKVNAEMVQWRMKYENNVIQ----RTEDLEDAKKELAIRLQEAAEAMGVAN 1420
Cdd:COG4942   106 LAE------LLRALYRLGRQPPLAL--LLSPEDFLDAVRRLQYLKYLAParreQAEELRADLAELAALRAELEAERAELE 177
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767926067 1421 ARNASLERARHQLQLELGDAlsdlgkvRSAAARLDQKQLQSGKALADWKQKHEESQALLDASQKEVQA 1488
Cdd:COG4942   178 ALLAELEEERAALEALKAER-------QKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAA 238
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1750-1945 1.22e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 49.76  E-value: 1.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1750 QKEAEEVVQECQNAEEKAKKAAIEAANLSEELKKKQDTIAHLERTRENMEQTITDLQKRLAEAEqmalmgsrKQIQKLES 1829
Cdd:COG4942    26 EAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELE--------KEIAELRA 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1830 RVRELEGELEGEIRR------------------SAEAQRGARRLERCIKELTYQAEEDKKNLSRMQTQMDKLQLKVQNYK 1891
Cdd:COG4942    98 ELEAQKEELAELLRAlyrlgrqpplalllspedFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELE 177
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 767926067 1892 QQVEVAETQANQYLSKYKKQQHELNEVKERAEVAESQVNKLKIKAREFGKKVQE 1945
Cdd:COG4942   178 ALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIAR 231
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
1049-1814 1.56e-05

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 50.34  E-value: 1.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1049 ALEQERKARMNceRELHKLEGnlklnRESM--ENLESSQRHLA---------EELRKKELELSQMNSKVENEKGLVAQL- 1116
Cdd:COG3096   302 AEEQYRLVEMA--RELEELSA-----RESDleQDYQAASDHLNlvqtalrqqEKIERYQEDLEELTERLEEQEEVVEEAa 374
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1117 -------------QKTVKELQTQIKDLKEKLEAERT------------TRAKMERERADLTQD-----LADLNERLEEVG 1166
Cdd:COG3096   375 eqlaeaearleaaEEEVDSLKSQLADYQQALDVQQTraiqyqqavqalEKARALCGLPDLTPEnaedyLAAFRAKEQQAT 454
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1167 gSSLAQLEitkkqetkfQKLhRDMEEATLHFETTSASLKKrhadslaeLEGQVENLQ--QVKQKLEKDKSDLQLevddLL 1244
Cdd:COG3096   455 -EEVLELE---------QKL-SVADAARRQFEKAYELVCK--------IAGEVERSQawQTARELLRRYRSQQA----LA 511
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1245 TRVEQMTRAKANAEKLctlyEERLHEATAKLDKVTQLANDLAAQKTKLWSESGEFLRRLEEKEALINQLSREKSNFTRQI 1324
Cdd:COG3096   512 QRLQQLRAQLAELEQR----LRQQQNAERLLEEFCQRIGQQLDAAEELEELLAELEAQLEELEEQAAEAVEQRSELRQQL 587
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1325 EDLRGQLEKETKSQSALAHALQKAQRDCDLLREQYEEEQEVKAELHRTLSKVNAEMVQwrmkyENNVIQRTEDLEDAKKE 1404
Cdd:COG3096   588 EQLRARIKELAARAPAWLAAQDALERLREQSGEALADSQEVTAAMQQLLEREREATVE-----RDELAARKQALESQIER 662
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1405 LA-------IRLQEAAEAMG----------------------VANARNA----SLERARHQLQlELGDALSDL----GKV 1447
Cdd:COG3096   663 LSqpggaedPRLLALAERLGgvllseiyddvtledapyfsalYGPARHAivvpDLSAVKEQLA-GLEDCPEDLylieGDP 741
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1448 RSAAARLDQKQLQSGKALA-----DWKQKHEESQALLD--ASQKEVQALSTELLKLKNTYEESIVGQETLRRENKNLQEE 1520
Cdd:COG3096   742 DSFDDSVFDAEELEDAVVVklsdrQWRYSRFPEVPLFGraAREKRLEELRAERDELAEQYAKASFDVQKLQRLHQAFSQF 821
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1521 ISNLTNQVREGtknltEMEKVKKLIEEEKTEVQVTLEETEGALERNESKILHF--QLELLEAKAELERKLSEKD--EEIE 1596
Cdd:COG3096   822 VGGHLAVAFAP-----DPEAELAALRQRRSELERELAQHRAQEQQLRQQLDQLkeQLQLLNKLLPQANLLADETlaDRLE 896
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1597 NFRRKQQCTIDSlQSSLDSEAKSRIEVTRLKKKMEED-LNEMELQLscanrQVSEATKSLGQLQIQIKDLQ--MQ----- 1668
Cdd:COG3096   897 ELREELDAAQEA-QAFIQQHGKALAQLEPLVAVLQSDpEQFEQLQA-----DYLQAKEQQRRLKQQIFALSevVQrrphf 970
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1669 -LDDSTQL---NSDLKEQvavaerrnsllqseledLRSLQEQTERGRRLSEEELLEATERinlfYTQNTSLLSQKKKLEA 1744
Cdd:COG3096   971 sYEDAVGLlgeNSDLNEK-----------------LRARLEQAEEARREAREQLRQAQAQ----YSQYNQVLASLKSSRD 1029
                         810       820       830       840       850       860       870
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767926067 1745 DVARMQKEAEEVVQE--CQNAEEKAKKAAIEAANLSEELKKKQDTIAHLERTRENMEQTITDLQKRLAEAEQ 1814
Cdd:COG3096  1030 AKQQTLQELEQELEElgVQADAEAEERARIRRDELHEELSQNRSRRSQLEKQLTRCEAEMDSLQKRLRKAER 1101
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
1638-1814 2.20e-05

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 49.06  E-value: 2.20e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1638 ELQLSCANRQVSEATKSLGQLQIQIKDLQMQLDDSTQLNSDLKEQVAVAERRNSLLQSELEDLRS-LQEQTER-GRRLSE 1715
Cdd:COG3883    15 DPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAeIEERREElGERARA 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1716 -----------EELLEAT---------ERINLFYTQNTSLLSQKKKLEADVARMQKEAEEVVQECQNaeeKAKKAAIEAA 1775
Cdd:COG3883    95 lyrsggsvsylDVLLGSEsfsdfldrlSALSKIADADADLLEELKADKAELEAKKAELEAKLAELEA---LKAELEAAKA 171
                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 767926067 1776 NLSEELKKKQDTIAHLERTRENMEQTITDLQKRLAEAEQ 1814
Cdd:COG3883   172 ELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEA 210
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1512-1926 2.20e-05

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 49.38  E-value: 2.20e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1512 RENKNLQEEISNLTNQVREgtknLTEMEKVKKLIEEEKTEVQVTLEETEGALERNESKILHFqlELLEAKAELERKLSEK 1591
Cdd:COG4717    71 KELKELEEELKEAEEKEEE----YAELQEELEELEEELEELEAELEELREELEKLEKLLQLL--PLYQELEALEAELAEL 144
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1592 DEEIENFRRKQQctidslqssldseakSRIEVTRLKKKMEEDLNEMELQLSCANRQVSEATKSlgqlqiQIKDLQMQLDD 1671
Cdd:COG4717   145 PERLEELEERLE---------------ELRELEEELEELEAELAELQEELEELLEQLSLATEE------ELQDLAEELEE 203
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1672 STQLNSDLKEQVAVAERRNSLLQSELEDLRSLQEQTERGRRLSEEE-LLEATERINLFYTQNTSLLSQKKKLEADVA--- 1747
Cdd:COG4717   204 LQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERLKEARlLLLIAAALLALLGLGGSLLSLILTIAGVLFlvl 283
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1748 -----------RMQKEAEEVVQECQNAEEKAKKAAIEAANLSEELKKKQD-TIAHLERTRENMEQTITDLQKRLAEAEQM 1815
Cdd:COG4717   284 gllallflllaREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDlSPEELLELLDRIEELQELLREAEELEEEL 363
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1816 ALMGSRKQIQKLesrVRELEGELEGEIRRSAEAQRGARRLERCIKELTYQAEEDKKNLSRMQTQMDK--LQLKVQNYKQQ 1893
Cdd:COG4717   364 QLEELEQEIAAL---LAEAGVEDEEELRAALEQAEEYQELKEELEELEEQLEELLGELEELLEALDEeeLEEELEELEEE 440
                         410       420       430
                  ....*....|....*....|....*....|...
gi 767926067 1894 VEVAETQANQYLSKYKKQQHELNEVKERAEVAE 1926
Cdd:COG4717   441 LEELEEELEELREELAELEAELEQLEEDGELAE 473
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
860-1140 2.23e-05

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 49.72  E-value: 2.23e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   860 EVAGLKEECAQLQKAL-EKSEFQR--EELKAKQvsltqekNDLILQLQAEQETLANVEEQCEWLIKSKIQLEARVKELSE 936
Cdd:pfam05483  406 ELEELKKILAEDEKLLdEKKQFEKiaEELKGKE-------QELIFLLQAREKEIHDLEIQLTAIKTSEEHYLKEVEDLKT 478
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   937 RVEEEEEINSELTARGRKLEDECFELKKEIDDLETMLVKSEKEKRTTEHKVKNLTEEVEFLNEDISKLNRAAKVVQEAHQ 1016
Cdd:pfam05483  479 ELEKEKLKNIELTAHCDKLLLENKELTQEASDMTLELKKHQEDIINCKKQEERMLKQIENLEEKEMNLRDELESVREEFI 558
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1017 QTLDD----LHMEEEKLSSLSKANLKLEQQVDELEGALEQERKARMNCERELHKL-EGNLKLNRESmeNLESSQRHLAE- 1090
Cdd:pfam05483  559 QKGDEvkckLDKSEENARSIEYEVLKKEKQMKILENKCNNLKKQIENKNKNIEELhQENKALKKKG--SAENKQLNAYEi 636
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|
gi 767926067  1091 ELRKKELELSQMNSKVENekgLVAQLQKTVKELQTQIKDLKEKLEAERTT 1140
Cdd:pfam05483  637 KVNKLELELASAKQKFEE---IIDNYQKEIEDKKISEEKLLEEVEKAKAI 683
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
1113-1434 2.43e-05

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 49.35  E-value: 2.43e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1113 VAQLQKTVKELQTQIKdlKEKLEAERTTRAKMERERAdltqdlADLNERLEEVGGSSLAQLEitkKQETKFQKLHRDMEE 1192
Cdd:pfam17380  277 IVQHQKAVSERQQQEK--FEKMEQERLRQEKEEKARE------VERRRKLEEAEKARQAEMD---RQAAIYAEQERMAME 345
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1193 ATLHFETTSASLKKRHADSLAELEGQVEnLQQVKQkLEKdksdLQLEVDDLLTRVEQMTRAkanAEKLCTLYEERLHeat 1272
Cdd:pfam17380  346 RERELERIRQEERKRELERIRQEEIAME-ISRMRE-LER----LQMERQQKNERVRQELEA---ARKVKILEEERQR--- 413
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1273 akldKVTQLANDLAAQKTKLWSESGEFLRRLEEKEAL-INQLSREKSNFTRQIEDLRGQLEKETKSQSalahALQKAQRD 1351
Cdd:pfam17380  414 ----KIQQQKVEMEQIRAEQEEARQREVRRLEEERAReMERVRLEEQERQQQVERLRQQEEERKRKKL----ELEKEKRD 485
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1352 CDLLREQYEE--EQEVKAELHRTLSKVNA-EMVQWRMKYENNVI----QRTEDLEDAKKELAI----RLQEAAEAMGVAN 1420
Cdd:pfam17380  486 RKRAEEQRRKilEKELEERKQAMIEEERKrKLLEKEMEERQKAIyeeeRRREAEEERRKQQEMeerrRIQEQMRKATEER 565
                          330
                   ....*....|....
gi 767926067  1421 ARNASLERARHQLQ 1434
Cdd:pfam17380  566 SRLEAMEREREMMR 579
PLN03229 PLN03229
acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Provisional
953-1276 2.70e-05

acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Provisional


Pssm-ID: 178768 [Multi-domain]  Cd Length: 762  Bit Score: 49.47  E-value: 2.70e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  953 RKLEDECFELKKEIDDLETMLVKS---------EKEKRTTEHKVKN------LTEEVEFLNEDISKLNRAAKVVQEAHQQ 1017
Cdd:PLN03229  432 RELEGEVEKLKEQILKAKESSSKPselalnemiEKLKKEIDLEYTEaviamgLQERLENLREEFSKANSQDQLMHPVLME 511
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1018 TLDDLHMEEEKLSSLSKANLKLEQQVDELEGALEQERKARMNCERELHKLEGNLKLnRESMENLESSQRHlaeELRKKEL 1097
Cdd:PLN03229  512 KIEKLKDEFNKRLSRAPNYLSLKYKLDMLNEFSRAKALSEKKSKAEKLKAEINKKF-KEVMDRPEIKEKM---EALKAEV 587
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1098 ELSQMNSKVENEKGLVAQLQKTVKELQTQIKDLKEK--LEAERTTRAKMERERADLTQDLADLNERLEEvggsslaqlEI 1175
Cdd:PLN03229  588 ASSGASSGDELDDDLKEKVEKMKKEIELELAGVLKSmgLEVIGVTKKNKDTAEQTPPPNLQEKIESLNE---------EI 658
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1176 TKKQE--TKFQKLHRDMEEATLHFETTSASLKKRHADSLAELEgqvenlQQVKQKLEK--DKSDLQLEVDDLltRVEQMT 1251
Cdd:PLN03229  659 NKKIErvIRSSDLKSKIELLKLEVAKASKTPDVTEKEKIEALE------QQIKQKIAEalNSSELKEKFEEL--EAELAA 730
                         330       340
                  ....*....|....*....|....*
gi 767926067 1252 RAKANAEKLCTLYEERLHEATAKLD 1276
Cdd:PLN03229  731 ARETAAESNGSLKNDDDKEEDSKED 755
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1405-1620 2.96e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 48.61  E-value: 2.96e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1405 LAIRLQEAAEAMGVANARNASLERARHQLQLELGDALSDLGKVRSAAARLDQKQLQSGKALADWKQKHEESQALLDASQK 1484
Cdd:COG4942    11 LALAAAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEK 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1485 EVQALSTELLKLKNTYEESIVGQETLRREN------------------KNLQEEISNLTNQVREGTKNLTEMEKVKKLIE 1546
Cdd:COG4942    91 EIAELRAELEAQKEELAELLRALYRLGRQPplalllspedfldavrrlQYLKYLAPARREQAEELRADLAELAALRAELE 170
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767926067 1547 EEKTEVQVTLEETEGALERNESKilhfQLELLEAKAELERKLSEKDEEIENFRRKQQcTIDSLQSSLDSEAKSR 1620
Cdd:COG4942   171 AERAELEALLAELEEERAALEAL----KAERQKLLARLEKELAELAAELAELQQEAE-ELEALIARLEAEAAAA 239
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1299-1717 4.99e-05

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 48.23  E-value: 4.99e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1299 FLRRLE-EKEALINQLSREKSNFTRQIEDLRGQLEKETKSQSALAHALQKAQRdcdlLREQYEEEQEVKAELHRTLSKVN 1377
Cdd:COG4717    47 LLERLEkEADELFKPQGRKPELNLKELKELEEELKEAEEKEEEYAELQEELEE----LEEELEELEAELEELREELEKLE 122
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1378 AEMVQWRmkyennVIQRTEDLEDAKKELAIRLQEAAEAMGVANARNASLERARHQLQlELGDALSDLGKVRSAAARLDQK 1457
Cdd:COG4717   123 KLLQLLP------LYQELEALEAELAELPERLEELEERLEELRELEEELEELEAELA-ELQEELEELLEQLSLATEEELQ 195
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1458 QLQsgKALADWKQKHEESQALLDASQKEVQALSTELLKLKNTYEE------------------SIVGQETLRRENKNLQE 1519
Cdd:COG4717   196 DLA--EELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAaaleerlkearlllliaaALLALLGLGGSLLSLIL 273
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1520 EISNL------------TNQVREGTKNLTEMEKVKKLIEEEKTEvQVTLEETEGALERNESKILHFQLELLEAKAELERK 1587
Cdd:COG4717   274 TIAGVlflvlgllallfLLLAREKASLGKEAEELQALPALEELE-EEELEELLAALGLPPDLSPEELLELLDRIEELQEL 352
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1588 LSEKDE-----EIENFRRKQQCTIDSLQSSLDSEAKSRIEVTRLKKKMEEDLNEMELQLSCANRQVSE--ATKSLGQLQI 1660
Cdd:COG4717   353 LREAEEleeelQLEELEQEIAALLAEAGVEDEEELRAALEQAEEYQELKEELEELEEQLEELLGELEEllEALDEEELEE 432
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 767926067 1661 QIKDLQMQLDDSTQLNSDLKEQVAVAERRNSLLQSELEDLRSLQEQTERGRRLSEEE 1717
Cdd:COG4717   433 ELEELEEELEELEEELEELREELAELEAELEQLEEDGELAELLQELEELKAELRELA 489
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1644-1868 5.99e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 47.45  E-value: 5.99e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1644 ANRQVSEATKSLGQLQIQIKDLQMQLDDSTQLNSDLKEQVAVAERRNSLLQSELEDLrslqeqtERGRRLSEEELLEATE 1723
Cdd:COG4942    18 QADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRAL-------EQELAALEAELAELEK 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1724 RINlfyTQNTSLLSQKKKLEADVARMQKEAE----------EVVQECQNAEEKAKKAAIEAANLSEELKKKQDTIAHLER 1793
Cdd:COG4942    91 EIA---ELRAELEAQKEELAELLRALYRLGRqpplalllspEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRA 167
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767926067 1794 TRENMEQTITDLQKRLaEAEQMALMGSRKQIQKLESRVRELEGELEGEIrrsAEAQRGARRLERCIKELTYQAEE 1868
Cdd:COG4942   168 ELEAERAELEALLAEL-EEERAALEALKAERQKLLARLEKELAELAAEL---AELQQEAEELEALIARLEAEAAA 238
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
1535-1631 7.03e-05

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 47.93  E-value: 7.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1535 LTEMEKVKKLIEEEKTEVQVTLEETEGALERNESKILHFQLELLEA-KAELERKLSEKDEEIENFRRKqqctIDSLQSSL 1613
Cdd:COG2433   382 LEELIEKELPEEEPEAEREKEHEERELTEEEEEIRRLEEQVERLEAeVEELEAELEEKDERIERLERE----LSEARSEE 457
                          90
                  ....*....|....*...
gi 767926067 1614 DSEAKSRIEVTRLKKKME 1631
Cdd:COG2433   458 RREIRKDREISRLDREIE 475
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
977-1143 7.09e-05

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 46.46  E-value: 7.09e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  977 EKEKRTTEHKVKNLTEEVEFLNEDISKLNRAAkvvqEAHQQTLDDLHMEEEKLSSLSKAnlkLEQQVDELEGALEQERKA 1056
Cdd:COG1579    16 DSELDRLEHRLKELPAELAELEDELAALEARL----EAAKTELEDLEKEIKRLELEIEE---VEARIKKYEEQLGNVRNN 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1057 RmncerELHKLEGNLKLNRESMENLESSQRHLAEELRKKELELSQMNSKVENEKGLVAQLQKTVKELQTQIKDLKEKLEA 1136
Cdd:COG1579    89 K-----EYEALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELEA 163

                  ....*..
gi 767926067 1137 ERTTRAK 1143
Cdd:COG1579   164 EREELAA 170
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
866-1342 8.25e-05

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 47.51  E-value: 8.25e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   866 EECAQLQKALEKSEFqreeLKAKQVSLTQE---KNDLILQLQAEQETLANVEEQCEWLIK-------SKIQ----LEARV 931
Cdd:pfam10174  272 EEIKQMEVYKSHSKF----MKNKIDQLKQElskKESELLALQTKLETLTNQNSDCKQHIEvlkesltAKEQraaiLQTEV 347
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   932 KELSERVEEEEEINSELTARGRKLEDECFELKKEIDDLETMLVKSEKEKRTTEHKVKNLTEEVEFLNEDISKLNRAAKVV 1011
Cdd:pfam10174  348 DALRLRLEEKESFLNKKTKQLQDLTEEKSTLAGEIRDLKDMLDVKERKINVLQKKIENLQEQLRDKDKQLAGLKERVKSL 427
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1012 QEAHQQTLDDLHMEEEKLSSLSKANLKLEQQVDELEGA----LEQERKARMNCERELHKLEGNLKLNRESMENLESSQRH 1087
Cdd:pfam10174  428 QTDSSNTDTALTTLEEALSEKERIIERLKEQREREDRErleeLESLKKENKDLKEKVSALQPELTEKESSLIDLKEHASS 507
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1088 LAEELRKKELELSQMNSKVENEKglvaqlqKTVKELQTQIKDLKEKLEAERTTRAKMERERAdLTQDLAdlneRLEEVGG 1167
Cdd:pfam10174  508 LASSGLKKDSKLKSLEIAVEQKK-------EECSKLENQLKKAHNAEEAVRTNPEINDRIRL-LEQEVA----RYKEESG 575
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1168 SSLAQLEitkkqetKFQKLHRDMEEATLHFETTSASLKKRHADSLAELEGQVENLQQVKQKLEKDKSDLQLEVddlltRV 1247
Cdd:pfam10174  576 KAQAEVE-------RLLGILREVENEKNDKDKKIAELESLTLRQMKEQNKKVANIKHGQQEMKKKGAQLLEEA-----RR 643
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1248 EQMTRAKANAEKlctlyeeRLHEATAKLDKVTQlanDLAAQKTKLWSESgeflRRLEEKEALINQLSREKsnftrqiedl 1327
Cdd:pfam10174  644 REDNLADNSQQL-------QLEELMGALEKTRQ---ELDATKARLSSTQ----QSLAEKDGHLTNLRAER---------- 699
                          490
                   ....*....|....*..
gi 767926067  1328 RGQLEK--ETKSQSALA 1342
Cdd:pfam10174  700 RKQLEEilEMKQEALLA 716
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
1323-1932 8.80e-05

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 47.73  E-value: 8.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1323 QIEDLRGQLE-KETKSQSALAHALQKAQRDCDLLREQYEEEQEVKAELHRTLSKVNAEMVQWRmkyennviQRTEDLEDA 1401
Cdd:PRK02224  188 SLDQLKAQIEeKEEKDLHERLNGLESELAELDEEIERYEEQREQARETRDEADEVLEEHEERR--------EELETLEAE 259
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1402 KKELAIRLQEAAEAMGVANARNASLERARHQLQLELGDALSDLGKVRSAAARLDQKQLQSGKALADWKQKHEESQALLDA 1481
Cdd:PRK02224  260 IEDLRETIAETEREREELAEEVRDLRERLEELEEERDDLLAEAGLDDADAEAVEARREELEDRDEELRDRLEECRVAAQA 339
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1482 SQKEVQALSTELLKLKNTYEEsivgqetLRRENKNLQEEISNLTNQVREGTKNLTEMEKVKKLIEEEKTEVQVTLEETEG 1561
Cdd:PRK02224  340 HNEEAESLREDADDLEERAEE-------LREEAAELESELEEAREAVEDRREEIEELEEEIEELRERFGDAPVDLGNAED 412
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1562 ALE--RNESKILHFQLELLEAKAELERKLSEKDEEIENFRRKQQCTidslQSSLDSEAKSRIEVTRLKK-KMEEDLNEME 1638
Cdd:PRK02224  413 FLEelREERDELREREAELEATLRTARERVEEAEALLEAGKCPECG----QPVEGSPHVETIEEDRERVeELEAELEDLE 488
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1639 LQLSCANRQVSEAtKSLGQLQIQIKDLQMQLDDSTQLnsdlkeqvaVAERRNSLlqseledlrslQEQTERGRRLSEEel 1718
Cdd:PRK02224  489 EEVEEVEERLERA-EDLVEAEDRIERLEERREDLEEL---------IAERRETI-----------EEKRERAEELRER-- 545
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1719 leaterinlfytqntsllsqKKKLEADVARMQKEAEEVVQECQnaeekakKAAIEAANLSEELKKKQDTIAHLER----- 1793
Cdd:PRK02224  546 --------------------AAELEAEAEEKREAAAEAEEEAE-------EAREEVAELNSKLAELKERIESLERirtll 598
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1794 -TRENMEQTITDLQKRLaeaEQMALMGSRKQIQKLESRVRELEGELEGEIRRSAEAQRGARRLErcikelTYQAEEDKKn 1872
Cdd:PRK02224  599 aAIADAEDEIERLREKR---EALAELNDERRERLAEKRERKRELEAEFDEARIEEAREDKERAE------EYLEQVEEK- 668
                         570       580       590       600       610       620
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1873 LSRMQTQMDKLQLKVQNYKQQVEvaetqanqylskykkqqhELNEVKERAEVAESQVNKL 1932
Cdd:PRK02224  669 LDELREERDDLQAEIGAVENELE------------------ELEELRERREALENRVEAL 710
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
1302-1810 9.25e-05

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 47.43  E-value: 9.25e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1302 RLEEKEALINQLSREKSNftRQIEDLRGQLEKETKSQSALAHALQKAQRDCDLL-REQYEEEQEVKAElhrTLSKVNAEM 1380
Cdd:pfam05557    3 ELIESKARLSQLQNEKKQ--MELEHKRARIELEKKASALKRQLDRESDRNQELQkRIRLLEKREAEAE---EALREQAEL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1381 VQWRMKYENNVIQRTEDLEDakkelaiRLQEAAEAMGVANARNASLERARHQLQLELGDALSDLGKVRsaaarlDQKQLQ 1460
Cdd:pfam05557   78 NRLKKKYLEALNKKLNEKES-------QLADAREVISCLKNELSELRRQIQRAELELQSTNSELEELQ------ERLDLL 144
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1461 SGKAladwkQKHEESQALLDASQKEvqaLSTELLKLKnTYEESIVGQETLRRENKNLQEEISNLTN------QVREGTKN 1534
Cdd:pfam05557  145 KAKA-----SEAEQLRQNLEKQQSS---LAEAEQRIK-ELEFEIQSQEQDSEIVKNSKSELARIPElekeleRLREHNKH 215
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1535 LTEMEKVKKLIEEEKTEVQVTLEETEGAlerneskilhfqlelLEAKAELERKLSEKDEEIENFRRKQQCTIDSLQSsld 1614
Cdd:pfam05557  216 LNENIENKLLLKEEVEDLKRKLEREEKY---------------REEAATLELEKEKLEQELQSWVKLAQDTGLNLRS--- 277
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1615 SEAKSRievtRLKKKMEEDLNEMElQLSCANRQVSEATKSLGQLQIQIKDLQMQLDDSTQLNSDLKEQVAVAERRNSLLQ 1694
Cdd:pfam05557  278 PEDLSR----RIEQLQQREIVLKE-ENSSLTSSARQLEKARRELEQELAQYLKKIEDLNKKLKRHKALVRRLQRRVLLLT 352
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1695 SELEDLRSLQE-------QTERGRRLSeEELLEATERINLFYTQNTSLLSQKKKLEADVARMQKEAEEVVQECQNAEEKA 1767
Cdd:pfam05557  353 KERDGYRAILEsydkeltMSNYSPQLL-ERIEEAEDMTQKMQAHNEEMEAQLSVAEEELGGYKQQAQTLERELQALRQQE 431
                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....
gi 767926067  1768 KKAAIEAANLS-EELKKKQDtiaHLERTRENMEQTITDLQKRLA 1810
Cdd:pfam05557  432 SLADPSYSKEEvDSLRRKLE---TLELERQRLREQKNELEMELE 472
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
871-1363 1.20e-04

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 47.07  E-value: 1.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  871 LQKALEKsefQREELKAKQVSLTQEKNDLILQLQAEQETLANVEEQCEWLIKSKIQLEARVKelserveeeeeinsELTA 950
Cdd:COG4717    47 LLERLEK---EADELFKPQGRKPELNLKELKELEEELKEAEEKEEEYAELQEELEELEEELE--------------ELEA 109
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  951 RGRKLEDECFELKKEIDDLETMLVKSEKEKRTTE--HKVKNLTEEVEFLNEDISKLNRAAKVVQEAHQQ----TLDDLHM 1024
Cdd:COG4717   110 ELEELREELEKLEKLLQLLPLYQELEALEAELAElpERLEELEERLEELRELEEELEELEAELAELQEEleelLEQLSLA 189
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1025 EEEKLSSLSKANLKLEQQVDELEGALEQERKARMNCERELHKLEGNLKLNRESMENLESSQRHLAEELRKKELELSQMNS 1104
Cdd:COG4717   190 TEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERLKEARLLLLIAAALLALLGLGGSLL 269
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1105 KVENEKGLVAQLQKTVKELQTQIKDLKEKLEAERTTRAKMERERADLTQdlADLNERLEEVGGSSLAQLEITKKQETKFQ 1184
Cdd:COG4717   270 SLILTIAGVLFLVLGLLALLFLLLAREKASLGKEAEELQALPALEELEE--EELEELLAALGLPPDLSPEELLELLDRIE 347
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1185 KLHRDMEEAT---------LHFETTSASLKKRHADSLAELEGQVENLQQvKQKLEKDKSDLQLEVDDLLTRVEQMtRAKA 1255
Cdd:COG4717   348 ELQELLREAEeleeelqleELEQEIAALLAEAGVEDEEELRAALEQAEE-YQELKEELEELEEQLEELLGELEEL-LEAL 425
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1256 NAEKLctlyEERLHEATAKLDKVTQLANDLAAQKTKLWSEsgefLRRLEEKEALinqlsrekSNFTRQIEDLRGQLEKET 1335
Cdd:COG4717   426 DEEEL----EEELEELEEELEELEEELEELREELAELEAE----LEQLEEDGEL--------AELLQELEELKAELRELA 489
                         490       500
                  ....*....|....*....|....*...
gi 767926067 1336 KSQSALAHALQKAQRdcdlLREQYEEEQ 1363
Cdd:COG4717   490 EEWAALKLALELLEE----AREEYREER 513
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1209-1453 1.26e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 46.68  E-value: 1.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1209 ADSLAELEGQVENLQQVKQKLEKDKSDLQLEVDDLLTRVEQMTRAKANAEKLCTLYEERLHEATAKLDKVTQLANDLAAQ 1288
Cdd:COG4942    19 ADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAE 98
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1289 KTKLWSESGEFLR---RLEEKEALINQLSREKSNftrQIEDLRGQLEKETKSQSALAHALQKAQRDCDLLREQYEEEQEV 1365
Cdd:COG4942    99 LEAQKEELAELLRalyRLGRQPPLALLLSPEDFL---DAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAE 175
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1366 KAELhrtlskvnaemvqwrmkyENNVIQRTEDLEDAKKELAIRLQEAAEAMGVANARNASLERARHQLQlelgDALSDLG 1445
Cdd:COG4942   176 LEAL------------------LAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELE----ALIARLE 233

                  ....*...
gi 767926067 1446 KVRSAAAR 1453
Cdd:COG4942   234 AEAAAAAE 241
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
1576-1928 1.34e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 46.97  E-value: 1.34e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1576 ELLEAKAELERKLSEKDEEIENFRRKQQctidslqssldsEAKSRIEVTRLK-KKMEEDLNEMELQLSCANRQVSEATKS 1654
Cdd:TIGR02168  148 EIIEAKPEERRAIFEEAAGISKYKERRK------------ETERKLERTRENlDRLEDILNELERQLKSLERQAEKAERY 215
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1655 LgQLQIQIKDLQMQLddstqLNSDLKEQVAVAERrnslLQSELEDLRSLQEQTERGRRLSEEELLEaterinlfytqnts 1734
Cdd:TIGR02168  216 K-ELKAELRELELAL-----LVLRLEELREELEE----LQEELKEAEEELEELTAELQELEEKLEE-------------- 271
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1735 LLSQKKKLEADVARMQKEAEEVVQECQNAEEKAKKAAIEAANLSEELKKKQDTIAHLERTRENMEQTITDLQKRLAEAEq 1814
Cdd:TIGR02168  272 LRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELK- 350
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1815 malmgsrkqiqklesrvreleGELEGEIRRSAEAQRGARRLERCIKELTYQAEEDKKNLSRMQTQMDKLQLKVQNYKQQV 1894
Cdd:TIGR02168  351 ---------------------EELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARL 409
                          330       340       350
                   ....*....|....*....|....*....|....
gi 767926067  1895 EvaetQANQYLSKYKKQQHELNEVKERAEVAESQ 1928
Cdd:TIGR02168  410 E----RLEDRRERLQQEIEELLKKLEEAELKELQ 439
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
1439-1629 1.37e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 45.69  E-value: 1.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1439 DALSDLGKVRSAAARLDQKQLQSGKALADWKQKHEESQALLDASQKEVQALSTELLKLKNTYEESivgqETLRRENKNLQ 1518
Cdd:COG1579     7 RALLDLQELDSELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEV----EARIKKYEEQL 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1519 EEISNlTNQVREGTKNLTEMEKVKKLIEEEKTEVQVTLEETEGALERNESKILHFQLELLEAKAELERKLSEKDEEIENF 1598
Cdd:COG1579    83 GNVRN-NKEYEALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEEL 161
                         170       180       190
                  ....*....|....*....|....*....|.
gi 767926067 1599 RRKqqctIDSLQSSLDSEAKSRIEVTRLKKK 1629
Cdd:COG1579   162 EAE----REELAAKIPPELLALYERIRKRKN 188
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1482-1946 1.37e-04

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 46.98  E-value: 1.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1482 SQKEVQALSTELLKLKNTYEESIVGQETLRRENKNLQEEISNLTNQVREGTKNLTEMEKVKKLIEEEKTEVQVTLEETEG 1561
Cdd:PRK03918  163 AYKNLGEVIKEIKRRIERLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREELEKLEKEVKELEELKEEIEE 242
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1562 aLERNESKILHFQLELLEAKAELERKLSEKDEEIENFRRKQQCTidslqSSLDSEAKSRIEVTRLKKKMEEDLNEMELQL 1641
Cdd:PRK03918  243 -LEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKEL-----KELKEKAEEYIKLSEFYEEYLDELREIEKRL 316
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1642 SCANRQVSEatkslgqLQIQIKDLQmqlDDSTQLNSDLKEQVAVAERRNSLLQS--ELEDLRSLQEQTERGR-RLSEEEL 1718
Cdd:PRK03918  317 SRLEEEING-------IEERIKELE---EKEERLEELKKKLKELEKRLEELEERheLYEEAKAKKEELERLKkRLTGLTP 386
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1719 LEATERINLFYTQNTSLLSQKKKLEADVARMQKEAEEVVQECQNAEEKAKKAAIEAANLSEE-----LKKKQDTIAHLER 1793
Cdd:PRK03918  387 EKLEKELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKKAKGKCPVCGRELTEEhrkelLEEYTAELKRIEK 466
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1794 TRENMEQTITDLQKRLAEAEQMALMGSR--------KQIQKLESR------------------VRELEGELEGEIRRSAE 1847
Cdd:PRK03918  467 ELKEIEEKERKLRKELRELEKVLKKESEliklkelaEQLKELEEKlkkynleelekkaeeyekLKEKLIKLKGEIKSLKK 546
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1848 AQRGARRLERCIKELTYQAEEDKKNLSRMQTQMDKLQLK-VQNYKQQVEVAETQANQYLS-------------KYKKQQH 1913
Cdd:PRK03918  547 ELEKLEELKKKLAELEKKLDELEEELAELLKELEELGFEsVEELEERLKELEPFYNEYLElkdaekelereekELKKLEE 626
                         490       500       510
                  ....*....|....*....|....*....|...
gi 767926067 1914 ELNEVKERAEVAESQVNKLKIKAREFGKKVQEE 1946
Cdd:PRK03918  627 ELDKAFEELAETEKRLEELRKELEELEKKYSEE 659
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1734-1931 1.45e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 46.30  E-value: 1.45e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1734 SLLSQKKKLEADVARMQKEAEEVVQECQNAEEKAKKAAIEAANLSEELKKKQDTIAHLERTRENMEQTITDLQKRLAE-- 1811
Cdd:COG4942    31 QLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQKEELAEll 110
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1812 --------AEQMALMGSRKQIQKLESRVRELEGELEGEIRRSAEAQRGARRLERCIKELTYQAEEDKKNLSRMQTQMDKL 1883
Cdd:COG4942   111 ralyrlgrQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELEALLAELEEERAAL 190
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 767926067 1884 QLKVQNYKQQVEVAETQANQY---LSKYKKQQHELNEVKERAEVAESQVNK 1931
Cdd:COG4942   191 EALKAERQKLLARLEKELAELaaeLAELQQEAEELEALIARLEAEAAAAAE 241
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
1455-1654 1.47e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 46.36  E-value: 1.47e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1455 DQKQLQSGKALADWKQKHEESQALLDASQKEVQALSTELLKLKNTYEESIVGQETLRRENKNLQEEISNLTNQVRE---- 1530
Cdd:COG3883    15 DPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGErara 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1531 ---------------GTKNLTE----MEKVKKLIEEEKTEVQvTLEETEGALERNESKILHFQLELLEAKAELERKLSEK 1591
Cdd:COG3883    95 lyrsggsvsyldvllGSESFSDfldrLSALSKIADADADLLE-ELKADKAELEAKKAELEAKLAELEALKAELEAAKAEL 173
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767926067 1592 DEEIEnfrrKQQCTIDSLQSSLDSEAKSRIEVTRLKKKMEEDLNEMELQLSCANRQVSEATKS 1654
Cdd:COG3883   174 EAQQA----EQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAA 232
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
1045-1185 1.50e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 45.30  E-value: 1.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1045 ELEGALEQERKARMNCERELHKLEGNLKLNRESMENLESSQRHLAEELRKKELELSQMNSKVENEKGL------------ 1112
Cdd:COG1579    14 ELDSELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQlgnvrnnkeyea 93
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767926067 1113 ----VAQLQKTVKELQTQIKDLKEKLEAERTTRAKMERERADLTQDLADLNERLEEVGGSSLAQLEITKKQETKFQK 1185
Cdd:COG1579    94 lqkeIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELEAEREELAA 170
HEC1 COG5185
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
945-1328 1.50e-04

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 46.87  E-value: 1.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  945 NSELTARGRKLEDECFELKKEIDDLETMLVKSEKEKRTTEHKVKNLT--------EEVEFLNEDISKLNRAAKVVQEAHQ 1016
Cdd:COG5185   156 VETGIIKDIFGKLTQELNQNLKKLEIFGLTLGLLKGISELKKAEPSGtvnsikesETGNLGSESTLLEKAKEIINIEEAL 235
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1017 QTLDDLHMEEEKLsslskanlklEQQVDELEGALEQERKARMNCERELHKLEGNLKLNREsmeNLESSQRHLAEELRKKE 1096
Cdd:COG5185   236 KGFQDPESELEDL----------AQTSDKLEKLVEQNTDLRLEKLGENAESSKRLNENAN---NLIKQFENTKEKIAEYT 302
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1097 LELSQMNSKVENEK-----GLVAQLQKTVKELQTQIKDLKEKLE------AERTTRAKMERERADLTQDLADLNERLEEV 1165
Cdd:COG5185   303 KSIDIKKATESLEEqlaaaEAEQELEESKRETETGIQNLTAEIEqgqeslTENLEAIKEEIENIVGEVELSKSSEELDSF 382
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1166 GgsslAQLEITKKqetKFQKLHRDMEEATLHFETTSASLKKRHADSLAELEGQVENL-------QQVKQKLEKDKSDLQL 1238
Cdd:COG5185   383 K----DTIESTKE---SLDEIPQNQRGYAQEILATLEDTLKAADRQIEELQRQIEQAtssneevSKLLNELISELNKVMR 455
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1239 EVDDLLTRVEQMTRAKANAEKLCTLYEerlheataKLDKVTQLANDLAAQKTKLWSESGEFLRRLEEKEALINQLSREKS 1318
Cdd:COG5185   456 EADEESQSRLEEAYDEINRSVRSKKED--------LNEELTQIESRVSTLKATLEKLRAKLERQLEGVRSKLDQVAESLK 527
                         410
                  ....*....|
gi 767926067 1319 NFTRQIEDLR 1328
Cdd:COG5185   528 DFMRARGYAH 537
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
898-1401 1.53e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 46.83  E-value: 1.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  898 DLILQLQAEQETLANVEEQCEWLIKSKIQLEA--RVKELSERVEEEEEINsELTARGRKLEDECFELKKEIDDLETMLVK 975
Cdd:COG4913   242 EALEDAREQIELLEPIRELAERYAAARERLAEleYLRAALRLWFAQRRLE-LLEAELEELRAELARLEAELERLEARLDA 320
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  976 SEKEKRTTEHKVKNL-TEEVEFLNEDISKLNRAAKVVQEAH---QQTLDDLHMEE-------EKLSSLSKANL------- 1037
Cdd:COG4913   321 LREELDELEAQIRGNgGDRLEQLEREIERLERELEERERRRarlEALLAALGLPLpasaeefAALRAEAAALLealeeel 400
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1038 -KLEQQVDELEGALEQERKARMNCERELHKLEGNLKLNRESMENLessQRHLAEELRKKEL------ELSQMNSKVENEK 1110
Cdd:COG4913   401 eALEEALAEAEAALRDLRRELRELEAEIASLERRKSNIPARLLAL---RDALAEALGLDEAelpfvgELIEVRPEEERWR 477
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1111 G-------------LV-----AQLQKTVKELqtqikDLKEKL--EAERTTRAKMERERADlTQDLAD------------L 1158
Cdd:COG4913   478 GaiervlggfaltlLVppehyAAALRWVNRL-----HLRGRLvyERVRTGLPDPERPRLD-PDSLAGkldfkphpfrawL 551
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1159 NERLEEVGG----SSLAQLE-----IT-----KKQETKFQKLHRDMEEATLHFETTSASLKKRHADSLAELEGQVENLQQ 1224
Cdd:COG4913   552 EAELGRRFDyvcvDSPEELRrhpraITragqvKGNGTRHEKDDRRRIRSRYVLGFDNRAKLAALEAELAELEEELAEAEE 631
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1225 VKQKLEKDKSDLQlEVDDLLTRVEQMTRAKANAEKLctlyEERLHEATAKLDKVTQLANDLAA---QKTKLWSESGEFLR 1301
Cdd:COG4913   632 RLEALEAELDALQ-ERREALQRLAEYSWDEIDVASA----EREIAELEAELERLDASSDDLAAleeQLEELEAELEELEE 706
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1302 RLEEKEALINQLSREKSNFTRQIEDLRGQLEKETKSQSA---------LAHALQKAQRdcDLLREQYEEEQEV-KAELHR 1371
Cdd:COG4913   707 ELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLelralleerFAAALGDAVE--RELRENLEERIDAlRARLNR 784
                         570       580       590
                  ....*....|....*....|....*....|
gi 767926067 1372 TLSKVNAEMVQWRMKYENNVIQRTEDLEDA 1401
Cdd:COG4913   785 AEEELERAMRAFNREWPAETADLDADLESL 814
PRK01156 PRK01156
chromosome segregation protein; Provisional
1210-1815 2.16e-04

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 46.43  E-value: 2.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1210 DSLAELEGQVENLQQVKQKLEKDKSDL-----QLEVD-----DLLTRVEQMTRAKANAEKLCTLYEERLHEATAKLDKVT 1279
Cdd:PRK01156  173 DVIDMLRAEISNIDYLEEKLKSSNLELenikkQIADDekshsITLKEIERLSIEYNNAMDDYNNLKSALNELSSLEDMKN 252
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1280 QLANDLAAQKTKL---------WSESGEFLRRLEEKEALINQLS-REKSNFTRQIEDLRgQLEKETKSQSALAHALQKAQ 1349
Cdd:PRK01156  253 RYESEIKTAESDLsmeleknnyYKELEERHMKIINDPVYKNRNYiNDYFKYKNDIENKK-QILSNIDAEINKYHAIIKKL 331
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1350 RDCDLLREQYEEEQEVKAELHRTLSkvnaEMVQWRMKYE---NNVIQRTEDLEDAKKELAIRLQEAAEAMGVANARNASL 1426
Cdd:PRK01156  332 SVLQKDYNDYIKKKSRYDDLNNQIL----ELEGYEMDYNsylKSIESLKKKIEEYSKNIERMSAFISEILKIQEIDPDAI 407
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1427 ERARHQLQLELGDALSDLGKVRsaaarldqkqlQSGKALADWKQKHEESQALLDAsQKEVQALSTELlklkntyeesivG 1506
Cdd:PRK01156  408 KKELNEINVKLQDISSKVSSLN-----------QRIRALRENLDELSRNMEMLNG-QSVCPVCGTTL------------G 463
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1507 QETLRRENKNLQEEISNLTNQVREgtknlteMEKVKKLIEEEKTEVQVTLEETEGAlerneskilhfQLELLEAKaelER 1586
Cdd:PRK01156  464 EEKSNHIINHYNEKKSRLEEKIRE-------IEIEVKDIDEKIVDLKKRKEYLESE-----------EINKSINE---YN 522
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1587 KLSEKDEEIENFRrkqqctiDSLQSSLDSEAKSRIEVTRLKKKMEEDLNEMELQLSCANRQVSeatkslgqlQIQIKDLQ 1666
Cdd:PRK01156  523 KIESARADLEDIK-------IKINELKDKHDKYEEIKNRYKSLKLEDLDSKRTSWLNALAVIS---------LIDIETNR 586
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1667 MQLDDstqlnsdLKEQVAVAERRNSLLQSELEDLRSLqeqTERGRRLSEEELLEATERINLFYTQNTSLLSQKKKLE--- 1743
Cdd:PRK01156  587 SRSNE-------IKKQLNDLESRLQEIEIGFPDDKSY---IDKSIREIENEANNLNNKYNEIQENKILIEKLRGKIDnyk 656
                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767926067 1744 ---ADVARMQKEAEEVVQECQNAEEKAKKAAIEAANLSEELKKKQDTIAHLERTRENMEQTITDLQKRLAEAEQM 1815
Cdd:PRK01156  657 kqiAEIDSIIPDLKEITSRINDIEDNLKKSRKALDDAKANRARLESTIEILRTRINELSDRINDINETLESMKKI 731
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
1413-1603 2.27e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 45.59  E-value: 2.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1413 AEAMGVANARNASLERARHQLQLELGDALSDLGKVRSAAARLDQKQLQSGKALADWKQKHEESQALLDASQKEVQALSTE 1492
Cdd:COG3883     1 ALALALAAPTPAFADPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1493 LLKLKNTYEESIVG-QETLRREN--------KNLQEEISNLTNQVREGTKNLTEMEKVKKLIEEektevqvtLEETEGAL 1563
Cdd:COG3883    81 IEERREELGERARAlYRSGGSVSyldvllgsESFSDFLDRLSALSKIADADADLLEELKADKAE--------LEAKKAEL 152
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 767926067 1564 ERNESKILHFQLELLEAKAELERKLSEKDEEIENFRRKQQ 1603
Cdd:COG3883   153 EAKLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEA 192
PRK01156 PRK01156
chromosome segregation protein; Provisional
1042-1600 2.56e-04

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 46.05  E-value: 2.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1042 QVDELEGALEQERKARMNCERELHKLEGNLKLNRESMENLE---SSQRHLAEELRKKELELSQMNSKVENEKGLVAQLQK 1118
Cdd:PRK01156  139 EMDSLISGDPAQRKKILDEILEINSLERNYDKLKDVIDMLRaeiSNIDYLEEKLKSSNLELENIKKQIADDEKSHSITLK 218
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1119 TVKELQTQIKDLKEK----------LEAERTTRAKMERERADLTQDLADLNERLEEVGGSSLAQLEITKKQETK------ 1182
Cdd:PRK01156  219 EIERLSIEYNNAMDDynnlksalneLSSLEDMKNRYESEIKTAESDLSMELEKNNYYKELEERHMKIINDPVYKnrnyin 298
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1183 -FQKLHRDMEEATLHFETTSASLKKRHADSLAELEGQVENLQQVKQKLEKDksDLQLEVDDLLTRVEQMTRAKANAEKLC 1261
Cdd:PRK01156  299 dYFKYKNDIENKKQILSNIDAEINKYHAIIKKLSVLQKDYNDYIKKKSRYD--DLNNQILELEGYEMDYNSYLKSIESLK 376
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1262 TLYEERLHEATAKLDKVTQLANDLAAQKTKLWSESGEFLRRLEEKEALINQLSREKSNFTRQIEDLRGQLE--------- 1332
Cdd:PRK01156  377 KKIEEYSKNIERMSAFISEILKIQEIDPDAIKKELNEINVKLQDISSKVSSLNQRIRALRENLDELSRNMEmlngqsvcp 456
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1333 ------KETKSQSALAHALQKAQR---DCDLLREQYEEEQEVKAELHRTLSKVNAEMVQWRMKYENNVIQRTEDLEDAKK 1403
Cdd:PRK01156  457 vcgttlGEEKSNHIINHYNEKKSRleeKIREIEIEVKDIDEKIVDLKKRKEYLESEEINKSINEYNKIESARADLEDIKI 536
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1404 ELAiRLQEAAEAMGVANARNASLErarhqlqleLGDalsdlgkvrsaaarLDQKQLQSGKALAdwkqkhEESQALLDASQ 1483
Cdd:PRK01156  537 KIN-ELKDKHDKYEEIKNRYKSLK---------LED--------------LDSKRTSWLNALA------VISLIDIETNR 586
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1484 KEVQALSTELLKLKNTYEESIVGQETLRRENKN----LQEEISNLTNQVREGTKNLTEMEKVKKLIE------------- 1546
Cdd:PRK01156  587 SRSNEIKKQLNDLESRLQEIEIGFPDDKSYIDKsireIENEANNLNNKYNEIQENKILIEKLRGKIDnykkqiaeidsii 666
                         570       580       590       600       610       620
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767926067 1547 EEKTEVQVTLEETEGALERNESKILHFQLELLEAKA----------ELERKLSEKDEEIENFRR 1600
Cdd:PRK01156  667 PDLKEITSRINDIEDNLKKSRKALDDAKANRARLEStieilrtrinELSDRINDINETLESMKK 730
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
1476-1707 2.97e-04

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 45.66  E-value: 2.97e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1476 QALLDASQKE----VQALSTELLKLKNTYEESIVGQETLRRENKNLQEEISNLTNQVREGTKNLTEMEKVKKLIE----- 1546
Cdd:pfam07888   33 QNRLEECLQEraelLQAQEAANRQREKEKERYKRDREQWERQRRELESRVAELKEELRQSREKHEELEEKYKELSassee 112
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1547 --EEKTEVQVTLEETEGALERNESKILHFQLELLEAKAELERkLSEKDEEIENFRRKQQCTIDSLQSSLDSeakSRIEVT 1624
Cdd:pfam07888  113 lsEEKDALLAQRAAHEARIRELEEDIKTLTQRVLERETELER-MKERAKKAGAQRKEEEAERKQLQAKLQQ---TEEELR 188
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1625 RLKKKMEEDLNEMELQLSCANRQVSEATKsLGQLQIQIKDLQMQLDDSTQLNSDLKEQVAVAERRNSLLQSELEDLRSLQ 1704
Cdd:pfam07888  189 SLSKEFQELRNSLAQRDTQVLQLQDTITT-LTQKLTTAHRKEAENEALLEELRSLQERLNASERKVEGLGEELSSMAAQR 267

                   ...
gi 767926067  1705 EQT 1707
Cdd:pfam07888  268 DRT 270
46 PHA02562
endonuclease subunit; Provisional
927-1190 3.21e-04

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 45.78  E-value: 3.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  927 LEARVKELSERVEEEEEINSELTARGRKLEDECFELKKEIddletmlvKSEKEKRTTEhkVKNLTEEVEFLNEDISKLNR 1006
Cdd:PHA02562  193 IQQQIKTYNKNIEEQRKKNGENIARKQNKYDELVEEAKTI--------KAEIEELTDE--LLNLVMDIEDPSAALNKLNT 262
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1007 AAKVVQEAHQQTLDDLHMEEE---------KLSSLSKANLKLEQQVDELEGALEQERKARMNcerelhklegnlklnres 1077
Cdd:PHA02562  263 AAAKIKSKIEQFQKVIKMYEKggvcptctqQISEGPDRITKIKDKLKELQHSLEKLDTAIDE------------------ 324
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1078 menlESSQRHLAEELRKKELELsqmNSKVENEKGLVAQLQKTVKELQTQIKDLKEkleaerttrakmerERADLTQDLAD 1157
Cdd:PHA02562  325 ----LEEIMDEFNEQSKKLLEL---KNKISTNKQSLITLVDKAKKVKAAIEELQA--------------EFVDNAEELAK 383
                         250       260       270
                  ....*....|....*....|....*....|...
gi 767926067 1158 LNERLEEVggsslaqleITKKQETKFQKLHRDM 1190
Cdd:PHA02562  384 LQDELDKI---------VKTKSELVKEKYHRGI 407
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
1265-1492 3.26e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 45.21  E-value: 3.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1265 EERLHEATAKLDKVTQLANDLAAQKTKLWSESGEFLRRLEEKEALINQLSREKSNFTRQIEDLRGQLEKETKSQSALAHA 1344
Cdd:COG3883    15 DPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGERARA 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1345 LQKAQRDCDLLrEQYEEEQEVKAELHRtlskvnAEMVQWRMKYENNVIQRT----EDLEDAKKELAIRLQEAAEAMGVAN 1420
Cdd:COG3883    95 LYRSGGSVSYL-DVLLGSESFSDFLDR------LSALSKIADADADLLEELkadkAELEAKKAELEAKLAELEALKAELE 167
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767926067 1421 ARNASLERARHQLQLELGDALSDLGKVRSAAARLDQKQLQSGKALADWKQKHEESQALLDASQKEVQALSTE 1492
Cdd:COG3883   168 AAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA 239
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
855-1165 3.35e-04

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 45.27  E-value: 3.35e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   855 SEVGEEVAGLKEECAQLQKALEKSEFQREELKAKQVSLTQEKNDLILQLQAEQETLANVEEQCEWLIKSKIQLEA----- 929
Cdd:pfam07888   76 RELESRVAELKEELRQSREKHEELEEKYKELSASSEELSEEKDALLAQRAAHEARIRELEEDIKTLTQRVLERETelerm 155
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   930 --RVKELSERVEEEEEINSELTARGRKLEDECFELKKEIDDLETMLVKSEKEKRTTEHKVKNLTEEV------EFLNEDI 1001
Cdd:pfam07888  156 keRAKKAGAQRKEEEAERKQLQAKLQQTEEELRSLSKEFQELRNSLAQRDTQVLQLQDTITTLTQKLttahrkEAENEAL 235
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1002 SKLNRAAKVVQEAHQQTLDDLHMEEEKLSS--------LSKANLKLEQQVDELEGALEQERKARMNCERELHKLEGNLKL 1073
Cdd:pfam07888  236 LEELRSLQERLNASERKVEGLGEELSSMAAqrdrtqaeLHQARLQAAQLTLQLADASLALREGRARWAQERETLQQSAEA 315
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1074 NRESMENLESSQRHLAEELRKKELELSQMNSKVENEKGL-VAQLQKTVKELQtqikDLKEKLEAERTTRAKMERERADLT 1152
Cdd:pfam07888  316 DKDRIEKLSAELQRLEERLQEERMEREKLEVELGREKDCnRVQLSESRRELQ----ELKASLRVAQKEKEQLQAEKQELL 391
                          330
                   ....*....|...
gi 767926067  1153 QDLADLNERLEEV 1165
Cdd:pfam07888  392 EYIRQLEQRLETV 404
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
853-1086 3.40e-04

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 45.78  E-value: 3.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  853 KSSEVGEEVAGLKEECAQLQKALEKSEFQREELKAKQ--VSLTQEKNDLILQLQAEQETLANVEEQcewliksKIQLEAR 930
Cdd:COG3206   169 RREEARKALEFLEEQLPELRKELEEAEAALEEFRQKNglVDLSEEAKLLLQQLSELESQLAEARAE-------LAEAEAR 241
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  931 VKELSERVEEEEEINSELTArgrklEDECFELKKEIDDLETMLvkSEKEKRTTEH--KVKNLTEEVEFLNEDISKlnRAA 1008
Cdd:COG3206   242 LAALRAQLGSGPDALPELLQ-----SPVIQQLRAQLAELEAEL--AELSARYTPNhpDVIALRAQIAALRAQLQQ--EAQ 312
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767926067 1009 KVVQEAHQQtlddlhmeeekLSSLSKANLKLEQQVDELEGALEQERKArmncERELHKLEGNLKLNRESMENLESSQR 1086
Cdd:COG3206   313 RILASLEAE-----------LEALQAREASLQAQLAQLEARLAELPEL----EAELRRLEREVEVARELYESLLQRLE 375
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
1681-1945 3.46e-04

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 45.83  E-value: 3.46e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1681 EQVAVAERRNSLLQSE----LEDLRSLQEQTERGRRLSEE-ELLEATERINlfytQNTSLLSQKKKLEADVARMQKEAEE 1755
Cdd:TIGR02169  180 EEVEENIERLDLIIDEkrqqLERLRREREKAERYQALLKEkREYEGYELLK----EKEALERQKEAIERQLASLEEELEK 255
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1756 VVQECQNAEEKAKKAAIEAANLSEELKKK--------QDTIAHLERTRENMEQTITDLQKRLAEAEQmALMGSRKQIQKL 1827
Cdd:TIGR02169  256 LTEEISELEKRLEEIEQLLEELNKKIKDLgeeeqlrvKEKIGELEAEIASLERSIAEKERELEDAEE-RLAKLEAEIDKL 334
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1828 ESRVRELEGELEGEIRRSAEAQRGARRLERCIKELTYQAEEDKKNLSRMQTQMDKLQLKVQNYKQQVEVAETQANQYLSK 1907
Cdd:TIGR02169  335 LAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETRDELKDYREKLEKLKREINELKRELDRLQEE 414
                          250       260       270
                   ....*....|....*....|....*....|....*...
gi 767926067  1908 YKKQQHELNEVKERAEVAESQVNKLKIKAREFGKKVQE 1945
Cdd:TIGR02169  415 LQRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKK 452
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1675-1909 3.55e-04

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 45.39  E-value: 3.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1675 LNSDLKEQVAVAERRNSLLQSELEDLRSLQEQTERGRR--LSEEELLEATERINLFYTQNTSLLSQKKKLEADVARMQKE 1752
Cdd:COG3206   162 LEQNLELRREEARKALEFLEEQLPELRKELEEAEAALEefRQKNGLVDLSEEAKLLLQQLSELESQLAEARAELAEAEAR 241
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1753 AEEVvqecqNAEEKAKKAAIEAANLSEELKKKQDTIAHLERTRENMEQTITDLQKRLAEAeqmalmgsRKQIQKLESRVR 1832
Cdd:COG3206   242 LAAL-----RAQLGSGPDALPELLQSPVIQQLRAQLAELEAELAELSARYTPNHPDVIAL--------RAQIAALRAQLQ 308
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767926067 1833 ELEGELEGEIRRSAEAqrgARRLERCIKELTYQAEEDKKNLSRMQTQMDKLQlkvqnykQQVEVAETQANQYLSKYK 1909
Cdd:COG3206   309 QEAQRILASLEAELEA---LQAREASLQAQLAQLEARLAELPELEAELRRLE-------REVEVARELYESLLQRLE 375
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
1779-1886 3.95e-04

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 45.23  E-value: 3.95e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1779 EELKKKQDTIAHLERTRENMEQTITDLQKRLAEAEQmalmgsrkQIQKLESRVRELEGELEGEIRRSAEAQRGAR---RL 1855
Cdd:COG2433   406 RELTEEEEEIRRLEEQVERLEAEVEELEAELEEKDE--------RIERLERELSEARSEERREIRKDREISRLDReieRL 477
                          90       100       110
                  ....*....|....*....|....*....|.
gi 767926067 1856 ERCIKELTYQAEEDKKNLSRMQtQMDKLQLK 1886
Cdd:COG2433   478 ERELEEERERIEELKRKLERLK-ELWKLEHS 507
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
853-1440 4.60e-04

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 45.21  E-value: 4.60e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   853 KSSEVGEEVAGLKEECAQLQKALEKSEFQREELKAKQVSLTQEKndlILQLQAEQETLANVEEQCEWLIKS-KIQLEARV 931
Cdd:pfam12128  295 LDDQWKEKRDELNGELSAADAAVAKDRSELEALEDQHGAFLDAD---IETAAADQEQLPSWQSELENLEERlKALTGKHQ 371
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   932 KELSERVEEEEEINSELTARGRKLEDECFELKKEIDDL----ETMLVKSEKEKRTT-EHKVKNLTEEVEFLNEDISKLnr 1006
Cdd:pfam12128  372 DVTAKYNRRRSKIKEQNNRDIAGIKDKLAKIREARDRQlavaEDDLQALESELREQlEAGKLEFNEEEYRLKSRLGEL-- 449
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1007 aaKVVQEAHQQTLDDLHMEEEKLSSLSKANLKLEQQVDELEGALEQERKARMNCERELHKL-EGNLKLNR------ESME 1079
Cdd:pfam12128  450 --KLRLNQATATPELLLQLENFDERIERAREEQEAANAEVERLQSELRQARKRRDQASEALrQASRRLEErqsaldELEL 527
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1080 NLESSQRHLAEELRKKELELSQMNSKV--------------ENEKGLVAQLQKTVKELQTQIKDLKEKLEAERTTRAKME 1145
Cdd:pfam12128  528 QLFPQAGTLLHFLRKEAPDWEQSIGKVispellhrtdldpeVWDGSVGGELNLYGVKLDLKRIDVPEWAASEEELRERLD 607
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1146 RERADLtQDLADLNERLEEVGGSSLAQLEITKKQET-----------KFQKLHRDMEEATLHFETTSASLKKRHADSLAE 1214
Cdd:pfam12128  608 KAEEAL-QSAREKQAAAEEQLVQANGELEKASREETfartalknarlDLRRLFDEKQSEKDKKNKALAERKDSANERLNS 686
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1215 LEGQVENL----QQVKQKLEKDKSDLQLEVDDLLTRVEQMTRAKANAEKLCTLYEERLHEATAKLDKvTQLANDLAAqkt 1290
Cdd:pfam12128  687 LEAQLKQLdkkhQAWLEEQKEQKREARTEKQAYWQVVEGALDAQLALLKAAIAARRSGAKAELKALE-TWYKRDLAS--- 762
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1291 klwsesgeflrrLEEKEALINQLSREKSNFTRQIEDLRGQLEKETKSQSALAHA-LQKAQRDCDLLREQYEEEQEVKAEL 1369
Cdd:pfam12128  763 ------------LGVDPDVIAKLKREIRTLERKIERIAVRRQEVLRYFDWYQETwLQRRPRLATQLSNIERAISELQQQL 830
                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767926067  1370 HRTLSKV---NAEMVQWRMKYENNVIQRTEDLEDAKKELA----IRL-QEAAEAMGVANARNASLERARHQLQLELGDA 1440
Cdd:pfam12128  831 ARLIADTklrRAKLEMERKASEKQQVRLSENLRGLRCEMSklatLKEdANSEQAQGSIGERLAQLEDLKLKRDYLSESV 909
Golgin_A5 pfam09787
Golgin subfamily A member 5; Members of this family of proteins are involved in maintaining ...
1463-1676 4.70e-04

Golgin subfamily A member 5; Members of this family of proteins are involved in maintaining Golgi structure. They stimulate the formation of Golgi stacks and ribbons, and are involved in intra-Golgi retrograde transport. Two main interactions have been characterized: one with RAB1A that has been activated by GTP-binding and another with isoform CASP of CUTL1.


Pssm-ID: 462900 [Multi-domain]  Cd Length: 305  Bit Score: 44.36  E-value: 4.70e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1463 KALADWKQKHE---ESQALLDASQKEVQALSTELLKLKNTYEESIVGQET--LRRENKNLQEEISNLTNQVRE-GTKNLT 1536
Cdd:pfam09787    7 QELADYKQKAArilQSKEKLIASLKEGSGVEGLDSSTALTLELEELRQERdlLREEIQKLRGQIQQLRTELQElEAQQQE 86
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1537 EMEKVKKLIEEEKTEVQVTL---EETEGALERNESKILHFQLELLEAKAELERKLSEKDEEIEnfRRKQQCTIDSLQSSL 1613
Cdd:pfam09787   87 EAESSREQLQELEEQLATERsarREAEAELERLQEELRYLEEELRRSKATLQSRIKDREAEIE--KLRNQLTSKSQSSSS 164
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767926067  1614 DSEAKSRIevtrlkKKMEEDLNEMELQLSCANRQVSEATKSLGQLQIQIKDLQMQLDDSTQLN 1676
Cdd:pfam09787  165 QSELENRL------HQLTETLIQKQTMLEALSTEKNSLVLQLERMEQQIKELQGEGSNGTSIN 221
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
954-1912 4.98e-04

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 45.43  E-value: 4.98e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   954 KLEDECFELKKEIDDLETMLVKSEKEKRTTEHKVKN-----LTEEVEFLNEDISK-LNRaakvvqeahqqTLDDLHMEEE 1027
Cdd:TIGR01612  697 KLDDLKSKIDKEYDKIQNMETATVELHLSNIENKKNelldiIVEIKKHIHGEINKdLNK-----------ILEDFKNKEK 765
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1028 KLSSLSKANLKLEQQVDELEGALeQERKARMNCERELHklegNLKlNRESMENLESSQRHLaEELRKKELELSQMNSKVE 1107
Cdd:TIGR01612  766 ELSNKINDYAKEKDELNKYKSKI-SEIKNHYNDQINID----NIK-DEDAKQNYDKSKEYI-KTISIKEDEIFKIINEMK 838
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1108 NEKGLVaqLQKTVKELQTQiKDLKEKLEAERTTRAKMERE-RADLTQDlaDLNERLEEVGGSSLAQLEITKKQETKFQKL 1186
Cdd:TIGR01612  839 FMKDDF--LNKVDKFINFE-NNCKEKIDSEHEQFAELTNKiKAEISDD--KLNDYEKKFNDSKSLINEINKSIEEEYQNI 913
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1187 H--RDMEEATLHFETTSASLKKRHADSLAELEGQVENLQQVKQK--LEKDKSDlQLEvddlltrvEQMTRAKANAEKLCT 1262
Cdd:TIGR01612  914 NtlKKVDEYIKICENTKESIEKFHNKQNILKEILNKNIDTIKESnlIEKSYKD-KFD--------NTLIDKINELDKAFK 984
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1263 lyEERLHEATAKLDKVTQLANDLaaqKTKLWSESGEFL-RRLEEKEALINQLSREKSNFTRQIEDLrgQLEKETKSQSAL 1341
Cdd:TIGR01612  985 --DASLNDYEAKNNELIKYFNDL---KANLGKNKENMLyHQFDEKEKATNDIEQKIEDANKNIPNI--EIAIHTSIYNII 1057
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1342 AHALQKAQRDCDLLREQYEEEQEVkaelhrtlSKVNAEMVQWRMKYENnviqrtedLEDAKKELAIRLQEaaeamgvana 1421
Cdd:TIGR01612 1058 DEIEKEIGKNIELLNKEILEEAEI--------NITNFNEIKEKLKHYN--------FDDFGKEENIKYAD---------- 1111
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1422 rnaslerarhqlqlelgdalsDLGKVRSAAARLDQKQLQSGKALADWKQKHE----ESQALLDASQKEV-QALSTELLKL 1496
Cdd:TIGR01612 1112 ---------------------EINKIKDDIKNLDQKIDHHIKALEEIKKKSEnyidEIKAQINDLEDVAdKAISNDDPEE 1170
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1497 KNTYEESIVgqeTLRRENKNLQEEISNLTNQVREGTKNLTEMEKVKKL-IEEEKTEVQVTLEETEGALERNESKIlhfql 1575
Cdd:TIGR01612 1171 IEKKIENIV---TKIDKKKNIYDEIKKLLNEIAEIEKDKTSLEEVKGInLSYGKNLGKLFLEKIDEEKKKSEHMI----- 1242
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1576 ELLEAKAELERKLSEKDEEIENFRRKQQCTIDSLQSSLDSEAKSRIEVTRLKKKME--EDLNEMELQLSCANRQVSEATk 1653
Cdd:TIGR01612 1243 KAMEAYIEDLDEIKEKSPEIENEMGIEMDIKAEMETFNISHDDDKDHHIISKKHDEniSDIREKSLKIIEDFSEESDIN- 1321
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1654 slgqlQIQiKDLQMQLDDSTQLNSDLKEQVA-VAERRNSL----LQSELEDLRSLQEQTERGRRLSEEElLEATERINLF 1728
Cdd:TIGR01612 1322 -----DIK-KELQKNLLDAQKHNSDINLYLNeIANIYNILklnkIKKIIDEVKEYTKEIEENNKNIKDE-LDKSEKLIKK 1394
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1729 YTQNTSLLSQKKKLEADVarmqkeAEEVVQEC-QNAEEKAKKAAIEAANLSEELKKKQDTIAHLERTRENMEQTITDLQK 1807
Cdd:TIGR01612 1395 IKDDINLEECKSKIESTL------DDKDIDECiKKIKELKNHILSEESNIDTYFKNADENNENVLLLFKNIEMADNKSQH 1468
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1808 RLAEAEQMALMGSRKQIQKLESRVRELEGELEGEIRRSAEAQRGARRLERCIKELT-----YQAEEDKKNLSRMQTQMDK 1882
Cdd:TIGR01612 1469 ILKIKKDNATNDHDFNINELKEHIDKSKGCKDEADKNAKAIEKNKELFEQYKKDVTellnkYSALAIKNKFAKTKKDSEI 1548
                          970       980       990
                   ....*....|....*....|....*....|
gi 767926067  1883 LQLKVQNYKQQVEVAETQANQYLSKYKKQQ 1912
Cdd:TIGR01612 1549 IIKEIKDAHKKFILEAEKSEQKIKEIKKEK 1578
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
1039-1565 8.16e-04

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 44.56  E-value: 8.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1039 LEQQVDELEGALEQERKArmncERELHKLEGNLKLNRESMENLEssqrHLAEELRKKELELSQmnsKVENEKGLVAQLQK 1118
Cdd:COG3096   517 LRAQLAELEQRLRQQQNA----ERLLEEFCQRIGQQLDAAEELE----ELLAELEAQLEELEE---QAAEAVEQRSELRQ 585
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1119 TVKELQTQIKDLKEKLEAERTTRAKMERERADLTQDLADLNERLEEVggSSLAQLE---ITKKQETKFQKLHRDMEEATL 1195
Cdd:COG3096   586 QLEQLRARIKELAARAPAWLAAQDALERLREQSGEALADSQEVTAAM--QQLLEREreaTVERDELAARKQALESQIERL 663
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1196 H-----FETTSASLKK-----------------------------RHADSLAELEGQVENLQQvkqkLEKDKSDLQL--- 1238
Cdd:COG3096   664 SqpggaEDPRLLALAErlggvllseiyddvtledapyfsalygpaRHAIVVPDLSAVKEQLAG----LEDCPEDLYLieg 739
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1239 ---EVDDLLTRVEQMTRA-----------------------KANAEKLCTLYEER--LHEATA-------KLDKVTQLAN 1283
Cdd:COG3096   740 dpdSFDDSVFDAEELEDAvvvklsdrqwrysrfpevplfgrAAREKRLEELRAERdeLAEQYAkasfdvqKLQRLHQAFS 819
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1284 DLAAQKTKLWSEsgeflrrlEEKEALINQLSREKSNFTRQIEDLRGQlekETKSQSALAHA------LQK---------- 1347
Cdd:COG3096   820 QFVGGHLAVAFA--------PDPEAELAALRQRRSELERELAQHRAQ---EQQLRQQLDQLkeqlqlLNKllpqanllad 888
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1348 ---AQRdCDLLREQYEEEQEVKAELHR---TLSKVnAEMVQwrmkyennVIQRT--------EDLEDAKKELAiRLQEAA 1413
Cdd:COG3096   889 etlADR-LEELREELDAAQEAQAFIQQhgkALAQL-EPLVA--------VLQSDpeqfeqlqADYLQAKEQQR-RLKQQI 957
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1414 EAMGVANARNASLERARHQLQLELGDALSDlgKVRSAAARLDQKQLQSGKALADWKQKHEESQALL-------DASQKEV 1486
Cdd:COG3096   958 FALSEVVQRRPHFSYEDAVGLLGENSDLNE--KLRARLEQAEEARREAREQLRQAQAQYSQYNQVLaslkssrDAKQQTL 1035
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1487 QALSTELLKLKNTYEESIVgqETLRRENKNLQEEISNLTNQVREGTKNLT----EMEKVKKLIEEEKTEVQVTLEETEGA 1562
Cdd:COG3096  1036 QELEQELEELGVQADAEAE--ERARIRRDELHEELSQNRSRRSQLEKQLTrceaEMDSLQKRLRKAERDYKQEREQVVQA 1113

                  ...
gi 767926067 1563 LER 1565
Cdd:COG3096  1114 KAG 1116
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
992-1138 8.78e-04

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 44.08  E-value: 8.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  992 EEV--EFLNEDISKLNRAAKVVQEAHQQTLDDlhmEEEKLSSLSKANLKLEQQVDELEGALEQerkarmnCERELHKLEG 1069
Cdd:COG2433   379 EEAleELIEKELPEEEPEAEREKEHEERELTE---EEEEIRRLEEQVERLEAEVEELEAELEE-------KDERIERLER 448
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767926067 1070 NLKLNRESMEnlessqrhlaEELRKKElELSQMNSKVENEKGLVAQLQKTVKELQTQIKDLKE--KLEAER 1138
Cdd:COG2433   449 ELSEARSEER----------REIRKDR-EISRLDREIERLERELEEERERIEELKRKLERLKElwKLEHSG 508
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
1115-1372 8.97e-04

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 44.15  E-value: 8.97e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1115 QLQKTVKELQ----TQIKDLKEKLEAERTTrakmereraDLTQDLADLNERLEEVGG-SSLAQLEITKKQETKFQKLhrd 1189
Cdd:PRK05771   17 YKDEVLEALHelgvVHIEDLKEELSNERLR---------KLRSLLTKLSEALDKLRSyLPKLNPLREEKKKVSVKSL--- 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1190 mEEATLHFETTSASLkkrhADSLAELEGQVENLQQVKQKLEKDKSDLQ------LEVDDLLTR-----------VEQMTR 1252
Cdd:PRK05771   85 -EELIKDVEEELEKI----EKEIKELEEEISELENEIKELEQEIERLEpwgnfdLDLSLLLGFkyvsvfvgtvpEDKLEE 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1253 AKANAEKLCTLYEERLHE------ATAK--LDKVTQLANDLAAQKTKLwSESGEFLRRLEEKEALINQLSREksnftrqI 1324
Cdd:PRK05771  160 LKLESDVENVEYISTDKGyvyvvvVVLKelSDEVEEELKKLGFERLEL-EEEGTPSELIREIKEELEEIEKE-------R 231
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 767926067 1325 EDLRGQLEKETKSqsalahaLQKAQRDCDLLREQYEEEQEVKAELHRT 1372
Cdd:PRK05771  232 ESLLEELKELAKK-------YLEELLALYEYLEIELERAEALSKFLKT 272
PRK11281 PRK11281
mechanosensitive channel MscK;
1475-1732 1.10e-03

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 44.13  E-value: 1.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1475 SQALLDASQKEVQA-LSTELLKLKNTyeesivgqETLRRENKNLQEEISNLTNQVREGTKNLTEMEKVKKLIEEEKTEvQ 1553
Cdd:PRK11281   50 KQKLLEAEDKLVQQdLEQTLALLDKI--------DRQKEETEQLKQQLAQAPAKLRQAQAELEALKDDNDEETRETLS-T 120
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1554 VTLEETEGALERNESKILHFQLELLEAKAEL-------ERKLSEKDEeieNFRRKQQctIDSLQSSLDSEAKSRIEVTRL 1626
Cdd:PRK11281  121 LSLRQLESRLAQTLDQLQNAQNDLAEYNSQLvslqtqpERAQAALYA---NSQRLQQ--IRNLLKGGKVGGKALRPSQRV 195
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1627 KKKMEE-------DLNEMELQ-----LSCANRQVSEATKSLGQLQIQIKDLQ-----MQLDDSTQLNSDLKE-QVAVAER 1688
Cdd:PRK11281  196 LLQAEQallnaqnDLQRKSLEgntqlQDLLQKQRDYLTARIQRLEHQLQLLQeainsKRLTLSEKTVQEAQSqDEAARIQ 275
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 767926067 1689 RNSLLQSELEdlrslqeqteRGRRLSEEeLLEATERINLFYTQN 1732
Cdd:PRK11281  276 ANPLVAQELE----------INLQLSQR-LLKATEKLNTLTQQN 308
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1645-1898 1.20e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 43.85  E-value: 1.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1645 NRQVSEATKSLGQLQIQIKDLQMQLDDSTQLNSDLKEQ---VAVAERRNSLLQsELEDLRSLQEQTERGRRLSEEELLEA 1721
Cdd:COG3206   167 ELRREEARKALEFLEEQLPELRKELEEAEAALEEFRQKnglVDLSEEAKLLLQ-QLSELESQLAEARAELAEAEARLAAL 245
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1722 TERINLFYTQNTSLLS--QKKKLEADVARMQKEAEEvvqecqnaeekakkaaieaanLSEELKKKQDTIAHLERTRENME 1799
Cdd:COG3206   246 RAQLGSGPDALPELLQspVIQQLRAQLAELEAELAE---------------------LSARYTPNHPDVIALRAQIAALR 304
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1800 QTITDLQKRLAEAEQMALMGSRKQIQKLESRVRelegELEGEIRRSAEAQRGARRLERcikeltyQAEEDKKNLSRMQTQ 1879
Cdd:COG3206   305 AQLQQEAQRILASLEAELEALQAREASLQAQLA----QLEARLAELPELEAELRRLER-------EVEVARELYESLLQR 373
                         250
                  ....*....|....*....
gi 767926067 1880 MDKLQLKVQNYKQQVEVAE 1898
Cdd:COG3206   374 LEEARLAEALTVGNVRVID 392
PRK09039 PRK09039
peptidoglycan -binding protein;
1062-1193 1.24e-03

peptidoglycan -binding protein;


Pssm-ID: 181619 [Multi-domain]  Cd Length: 343  Bit Score: 43.42  E-value: 1.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1062 RELHKLEGNLKLNRESMENLESSQRHLAEELRKKELELSQMnskveneKGLVAQLQKTVKELQTQIKDLKEKLEAERTTR 1141
Cdd:PRK09039   60 SQIAELADLLSLERQGNQDLQDSVANLRASLSAAEAERSRL-------QALLAELAGAGAAAEGRAGELAQELDSEKQVS 132
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 767926067 1142 AKMERERADLTQDLADLNERLEEVGGSSLAQLEITKKQETKFQKLHRDMEEA 1193
Cdd:PRK09039  133 ARALAQVELLNQQIAALRRQLAALEAALDASEKRDRESQAKIADLGRRLNVA 184
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
1631-1944 1.26e-03

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 44.01  E-value: 1.26e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1631 EEDLNEMELQLSCANRQVSEATKSLGQLQIQIKDLQMQLDDSTQLNSDLKEQVAVAERRNSLLQSELEDLRSlqeqterg 1710
Cdd:pfam01576   11 EEELQKVKERQQKAESELKELEKKHQQLCEEKNALQEQLQAETELCAEAEEMRARLAARKQELEEILHELES-------- 82
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1711 rRLSEEElleatERinlfytqNTSLLSQKKKLEADVARMQKEAEEVVQECQNAEEKAKKAAIEAANLSEELKKKQDTIAH 1790
Cdd:pfam01576   83 -RLEEEE-----ER-------SQQLQNEKKKMQQHIQDLEEQLDEEEAARQKLQLEKVTTEAKIKKLEEDILLLEDQNSK 149
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1791 LERTRENMEQTITDLQKRLAEAEQMALMGSrKQIQKLESRVRELEGELEGEIRRSAEAQRGARRLERCIKELTYQAEEDK 1870
Cdd:pfam01576  150 LSKERKLLEERISEFTSNLAEEEEKAKSLS-KLKNKHEAMISDLEERLKKEEKGRQELEKAKRKLEGESTDLQEQIAELQ 228
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767926067  1871 KNLSRMQTQMDKLQLKVQNYKQQVEVAETQANQYLSKYKKQQHELNEVKERAEVAESQVNKLKIKAREFGKKVQ 1944
Cdd:pfam01576  229 AQIAELRAQLAKKEEELQAALARLEEETAQKNNALKKIRELEAQISELQEDLESERAARNKAEKQRRDLGEELE 302
PLN02939 PLN02939
transferase, transferring glycosyl groups
871-1141 1.35e-03

transferase, transferring glycosyl groups


Pssm-ID: 215507 [Multi-domain]  Cd Length: 977  Bit Score: 43.74  E-value: 1.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  871 LQKALEKSEFQREELKAKQVSLTqeKNDLILQLQAEQEtlANVEEQCEWLIKSKIQLEARVKELSERVEEEEEINSELTA 950
Cdd:PLN02939  158 LEKILTEKEALQGKINILEMRLS--ETDARIKLAAQEK--IHVEILEEQLEKLRNELLIRGATEGLCVHSLSKELDVLKE 233
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  951 RGRKLEDECFELKKEID---DLETMLVKSEKEKRTTEHKVKNLTEEVEFLNEDISKLNRA------AKVvqEAHQQTLDD 1021
Cdd:PLN02939  234 ENMLLKDDIQFLKAELIevaETEERVFKLEKERSLLDASLRELESKFIVAQEDVSKLSPLqydcwwEKV--ENLQDLLDR 311
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1022 LHMEEEKLSSLSKANLKLEQQVDELEGALEqerkarmncerelhklEGNL-KLNRESMENLESSQRHLAEELRKKELEls 1100
Cdd:PLN02939  312 ATNQVEKAALVLDQNQDLRDKVDKLEASLK----------------EANVsKFSSYKVELLQQKLKLLEERLQASDHE-- 373
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 767926067 1101 qMNSKVEnekglvaQLQKTVKELQTQIKDLKEklEAERTTR 1141
Cdd:PLN02939  374 -IHSYIQ-------LYQESIKEFQDTLSKLKE--ESKKRSL 404
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
1463-1812 1.56e-03

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 43.89  E-value: 1.56e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1463 KALADWKQKHEESQALLDASQKEVQALSTELLKLKNTYEESIVGQETlrrenKNLQEEISNLTNQVR--------EGTKN 1534
Cdd:TIGR01612  620 KKAIDLKKIIENNNAYIDELAKISPYQVPEHLKNKDKIYSTIKSELS-----KIYEDDIDALYNELSsivkenaiDNTED 694
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1535 LTEMEKVKKLIEEEKTEVQ----VTLEETEGALERNESKILHFqleLLEAKAELERKLS-EKDEEIENFRRKQQctidSL 1609
Cdd:TIGR01612  695 KAKLDDLKSKIDKEYDKIQnmetATVELHLSNIENKKNELLDI---IVEIKKHIHGEINkDLNKILEDFKNKEK----EL 767
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1610 QSSLDSEAKSRIEVTRLKKKMEEDLNEMELQLSCANRQVSEATKSLGQLQIQIKDLQMQLDDSTQLNSDLK----EQVAV 1685
Cdd:TIGR01612  768 SNKINDYAKEKDELNKYKSKISEIKNHYNDQINIDNIKDEDAKQNYDKSKEYIKTISIKEDEIFKIINEMKfmkdDFLNK 847
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1686 AERRNSLLQSELEDLRSLQEQ-TERGRRLSEEElleATERINLF---YTQNTSLLSQ-KKKLEADVARMQ--KEAEEVVQ 1758
Cdd:TIGR01612  848 VDKFINFENNCKEKIDSEHEQfAELTNKIKAEI---SDDKLNDYekkFNDSKSLINEiNKSIEEEYQNINtlKKVDEYIK 924
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 767926067  1759 ECQNAEEKAKKAAIEAANLSEELKKKQDTIAH---LERTREN-MEQTITDLQKRLAEA 1812
Cdd:TIGR01612  925 ICENTKESIEKFHNKQNILKEILNKNIDTIKEsnlIEKSYKDkFDNTLIDKINELDKA 982
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
944-1319 1.60e-03

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 43.67  E-value: 1.60e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   944 INSELTARGRKLEDECFELKKEIDDLETMLVKSEKEKRTTEhkvKNLTEEVEFLNEDISKLNRAAKVVQEAHQQTLDdlH 1023
Cdd:pfam12128  630 ANGELEKASREETFARTALKNARLDLRRLFDEKQSEKDKKN---KALAERKDSANERLNSLEAQLKQLDKKHQAWLE--E 704
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1024 MEEEKLSSLSKANLKL----------EQQVDELEGALEQERKARMN-CERELHKLEGNLKLNRESMENLESSQRHLA--- 1089
Cdd:pfam12128  705 QKEQKREARTEKQAYWqvvegaldaqLALLKAAIAARRSGAKAELKaLETWYKRDLASLGVDPDVIAKLKREIRTLErki 784
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1090 EELRKKELELSQ----MNSKVENEK-GLVAQLQKTVKELQTQIKDLKEKLEAERTTRAKMERERADLTQDLADLNERLEE 1164
Cdd:pfam12128  785 ERIAVRRQEVLRyfdwYQETWLQRRpRLATQLSNIERAISELQQQLARLIADTKLRRAKLEMERKASEKQQVRLSENLRG 864
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1165 VggsslaQLEITKkqeTKFQKLHRDMEEATLHFETTSASLKkrhaDSLAELEGQVEnlqQVKQKLEKDKSDLQLEVDDLL 1244
Cdd:pfam12128  865 L------RCEMSK---LATLKEDANSEQAQGSIGERLAQLE----DLKLKRDYLSE---SVKKYVEHFKNVIADHSGSGL 928
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1245 TRVEQMTRAKA---NAEKLCTLYEERLheatakLDKVTQLANDLAAQKTKLWSESG--------EFLRRLEEKEALINQL 1313
Cdd:pfam12128  929 AETWESLREEDhyqNDKGIRLLDYRKL------VPYLEQWFDVRVPQSIMVLREQVsilgvdltEFYDVLADFDRRIASF 1002

                   ....*.
gi 767926067  1314 SREKSN 1319
Cdd:pfam12128 1003 SRELQR 1008
HCR pfam07111
Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha ...
780-1237 1.67e-03

Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha helical coiled-coil rod HCR proteins. The function of HCR is unknown but it has been implicated in psoriasis in humans and is thought to affect keratinocyte proliferation.


Pssm-ID: 284517 [Multi-domain]  Cd Length: 749  Bit Score: 43.59  E-value: 1.67e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   780 GFLGQLEAIRDERLSKVFTLFQARAQGKLMRIKFQKILEERDALILIQWNIRAFMAVKNWPWmrlFFKIKPLVKSSEVGE 859
Cdd:pfam07111  173 GLEKSLNSLETKRAGEAKQLAEAQKEAELLRKQLSKTQEELEAQVTLVESLRKYVGEQVPPE---VHSQTWELERQELLD 249
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   860 EVAGLKEECAQLQKALEKSEFQREELKAKqvsLTQEKNDLILQLQAEQETLANVEEQCEWLIKSkiqlearvkelseRVE 939
Cdd:pfam07111  250 TMQHLQEDRADLQATVELLQVRVQSLTHM---LALQEEELTRKIQPSDSLEPEFPKKCRSLLNR-------------WRE 313
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   940 EEEEINSELTARGRKLEDECFELKKEIDDLETMLVKSEKEKRTTEHKVKNLTEEVEFLNEDISKLNRAAKVVQEAHQQTL 1019
Cdd:pfam07111  314 KVFALMVQLKAQDLEHRDSVKQLRGQVAELQEQVTSQSQEQAILQRALQDKAAEVEVERMSAKGLQMELSRAQEARRRQQ 393
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1020 DDLHMEEEKL----SSLSKANLKLEQQVDELEGALEQ--ERKARMN-CERELHKLEGnLKLNRESMENLESSQRHLAEEL 1092
Cdd:pfam07111  394 QQTASAEEQLkfvvNAMSSTQIWLETTMTRVEQAVARipSLSNRLSyAVRKVHTIKG-LMARKVALAQLRQESCPPPPPA 472
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1093 RKKELELS-QMNSKVENEKGLVAQLQKTVKELQTQIKDLKEKLEAERTTRAK----MERERADLTQDLADLNERLEEV-- 1165
Cdd:pfam07111  473 PPVDADLSlELEQLREERNRLDAELQLSAHLIQQEVGRAREQGEAERQQLSEvaqqLEQELQRAQESLASVGQQLEVArq 552
                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767926067  1166 -------GGSSLAQlEITKKQETKFQKLHRDMEEATLHFETTSASLKKRHADSLAELEGQVENLQQVKQKLEKDKSDLQ 1237
Cdd:pfam07111  553 gqqesteEAASLRQ-ELTQQQEIYGQALQEKVAEVETRLREQLSDTKRRLNEARREQAKAVVSLRQIQHRATQEKERNQ 630
PRK01156 PRK01156
chromosome segregation protein; Provisional
860-1410 1.72e-03

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 43.35  E-value: 1.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  860 EVAGLKEECAQLQKALEKSEFQREELKAKQVSLTQEKNDL---ILQLQAEQETLANVEEQCEWLIKSKIQLEARVKELSE 936
Cdd:PRK01156  198 ELENIKKQIADDEKSHSITLKEIERLSIEYNNAMDDYNNLksaLNELSSLEDMKNRYESEIKTAESDLSMELEKNNYYKE 277
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  937 RVEEEEEINSELTARGRKLEDECFELKKEIDDLETMLvksekekrttehkvKNLTEEVeflnedisklnraakvvqeahq 1016
Cdd:PRK01156  278 LEERHMKIINDPVYKNRNYINDYFKYKNDIENKKQIL--------------SNIDAEI---------------------- 321
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1017 QTLDDLHMEEEKLSSLSKANLKLEQQVDELEGALEQERKARMNCERELHKLEGNLKLNRESMENLESSQRHLAEELRKKE 1096
Cdd:PRK01156  322 NKYHAIIKKLSVLQKDYNDYIKKKSRYDDLNNQILELEGYEMDYNSYLKSIESLKKKIEEYSKNIERMSAFISEILKIQE 401
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1097 LELSQMNSKVENEKGLVAQLQKTVKELQTQIKDLKEKLEAERTTRA------------------KMERERADLTQDLADL 1158
Cdd:PRK01156  402 IDPDAIKKELNEINVKLQDISSKVSSLNQRIRALRENLDELSRNMEmlngqsvcpvcgttlgeeKSNHIINHYNEKKSRL 481
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1159 NERLEEVggsslaQLEITKKQETKFQ--KLHRDMEEATLHFETTSASLKKRHADSLAELEGQVENLQQVKQKLEKDKSDL 1236
Cdd:PRK01156  482 EEKIREI------EIEVKDIDEKIVDlkKRKEYLESEEINKSINEYNKIESARADLEDIKIKINELKDKHDKYEEIKNRY 555
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1237 Q-LEVDDLLTRVEQMTRAKANAEKL-CTLYEERLHEATAKLDKVTQLANDLAAQKTKLWSESGEFLRRLEEKEALINQLS 1314
Cdd:PRK01156  556 KsLKLEDLDSKRTSWLNALAVISLIdIETNRSRSNEIKKQLNDLESRLQEIEIGFPDDKSYIDKSIREIENEANNLNNKY 635
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1315 REKSNFTRQIEDLRGQLEkETKSQSALAHALQKAQRDcdlLREQYEEEQEVKAELHRTLSKVNAEMVQWRMKYENNvIQR 1394
Cdd:PRK01156  636 NEIQENKILIEKLRGKID-NYKKQIAEIDSIIPDLKE---ITSRINDIEDNLKKSRKALDDAKANRARLESTIEIL-RTR 710
                         570
                  ....*....|....*.
gi 767926067 1395 TEDLEDAKKELAIRLQ 1410
Cdd:PRK01156  711 INELSDRINDINETLE 726
ClpA COG0542
ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein ...
1060-1172 1.80e-03

ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440308 [Multi-domain]  Cd Length: 836  Bit Score: 43.53  E-value: 1.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1060 CERELHKLEGNL-KLNRESMENLESSQRHLAEELRKKELELSQMNSKVENEKGLVAQLQKtvkelqtqikdLKEKLEAER 1138
Cdd:COG0542   416 LERRLEQLEIEKeALKKEQDEASFERLAELRDELAELEEELEALKARWEAEKELIEEIQE-----------LKEELEQRY 484
                          90       100       110
                  ....*....|....*....|....*....|....*
gi 767926067 1139 TTRAKMERERADLTQDLADLNERL-EEVGGSSLAQ 1172
Cdd:COG0542   485 GKIPELEKELAELEEELAELAPLLrEEVTEEDIAE 519
HAP1_N pfam04849
HAP1 N-terminal conserved region; This family represents an N-terminal conserved region found ...
1505-1724 1.82e-03

HAP1 N-terminal conserved region; This family represents an N-terminal conserved region found in several huntingtin-associated protein 1 (HAP1) homologs. HAP1 binds to huntingtin in a polyglutamine repeat-length-dependent manner. However, its possible role in the pathogenesis of Huntington's disease is unclear. This family also includes a similar N-terminal conserved region from hypothetical protein products of ALS2CR3 genes found in the human juvenile amyotrophic lateral sclerosis critical region 2q33-2q34.


Pssm-ID: 461455 [Multi-domain]  Cd Length: 309  Bit Score: 42.71  E-value: 1.82e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1505 VGQETLRReNKNLQEEISNLTNQVREGTKNLT----EMEKVKKLI-------EEEKTEvqvtlEETEGALERNESKILHF 1573
Cdd:pfam04849   88 IGQSLLKQ-NSVLTERNEALEEQLGSAREEILqlrhELSKKDDLLqiysndaEESETE-----SSCSTPLRRNESFSSLH 161
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1574 QLELLEAkaeLERKLSEKDEEIEnfrrkqqctidslqsSLDSEA-KSRIEVTRLKKKMEEDLNEMELQLSCANRQVSEAT 1652
Cdd:pfam04849  162 GCVQLDA---LQEKLRGLEEENL---------------KLRSEAsHLKTETDTYEEKEQQLMSDCVEQLSEANQQMAELS 223
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1653 KSLG--------------QLQIQIKDLQMQLDDSTQLNSDLKEQVAVAERRNSLLQSELEDLRSLQEQTERGRRLSEEEL 1718
Cdd:pfam04849  224 EELArkmeenlrqqeeitSLLAQIVDLQHKCKELGIENEELQQHLQASKEAQRQLTSELQELQDRYAECLGMLHEAQEEL 303

                   ....*.
gi 767926067  1719 LEATER 1724
Cdd:pfam04849  304 KELRKK 309
TOPEUc smart00435
DNA Topoisomerase I (eukaryota); DNA Topoisomerase I (eukaryota), DNA topoisomerase V, Vaccina ...
982-1134 2.09e-03

DNA Topoisomerase I (eukaryota); DNA Topoisomerase I (eukaryota), DNA topoisomerase V, Vaccina virus topoisomerase, Variola virus topoisomerase, Shope fibroma virus topoisomeras


Pssm-ID: 214661 [Multi-domain]  Cd Length: 391  Bit Score: 42.72  E-value: 2.09e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067    982 TTEHKVKNLTEEVEFLNEDISKLNRAAKVVqeA----HQQTLDDLHmeeeklsslSKANLKLEQQVDELEGALEQERKAR 1057
Cdd:smart00435  232 TLQEQLKELTAKDGNVAEKILAYNRANREV--AilcnHQRTVSKTH---------EKSMEKLQEKIKALKYQLKRLKKMI 300
                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767926067   1058 MNCERElhklegnlklnRESMENLESSQRHLAEELRKKELELSQMNSKVENEKGLVAQLQKTVKELQTQIKDlKEKL 1134
Cdd:smart00435  301 LLFEMI-----------SDLKRKLKSKFERDNEKLDAEVKEKKKEKKKEEKKKKQIERLEERIEKLEVQATD-KEEN 365
CCDC73 pfam15818
Coiled-coil domain-containing protein 73 family; CCDC73 is a family of eukaryotic coiled-coil ...
854-1223 2.09e-03

Coiled-coil domain-containing protein 73 family; CCDC73 is a family of eukaryotic coiled-coil containing proteins. The function is not known. The alternative name is sarcoma antigen NY-SAR-79.


Pssm-ID: 464893 [Multi-domain]  Cd Length: 1048  Bit Score: 43.40  E-value: 2.09e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   854 SSEVGE-EVAGLKEECaqlqKALEKSEFQREelkaKQVSLTQEKNDLILQLQAEQETLANVEEQCEWLIKSKIQL--EAR 930
Cdd:pfam15818   86 ATEIKEkEIEGLKETL----KALQVSKYSLQ----KKVSEMEQKLQLHLLAKEDHHKQLNEIEKYYATITGQFGLvkENH 157
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   931 VKELSERVEEEEeINSELTARGRKLEDECFELKKEIDDLETMLVKSekeKRTTEHKVK----NLTEEVEFLNEDISKLNR 1006
Cdd:pfam15818  158 GKLEQNVQEAIQ-LNKRLSALNKKQESEICSLKKELKKVTSDLIKS---KVTCQYKMGeeniNLTIKEQKFQELQERLNM 233
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1007 AAKVVQEAHQQTLddlHMEEEK---LSSLSKANLKLEQQVD---ELEGALEQERKARMNCERELHKLEGNLKLNRESMEN 1080
Cdd:pfam15818  234 ELELNKKINEEIT---HIQEEKqdiIISFQHMQQLLQQQTQantEMEAELKALKENNQTLERDNELQREKVKENEEKFLN 310
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1081 LESSQRHLAEELRKKELELSQMNSKVENEKGLVAQLQKTVKELQTQIKDLKEKLEAERttrakmereradlTQDLADLNe 1160
Cdd:pfam15818  311 LQNEHEKALGTWKKHVEELNGEINEIKNELSSLKETHIKLQEHYNKLCNQKKFEEDKK-------------FQNVPEVN- 376
                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767926067  1161 rlEEVGGSSLAQLEITKKQetKFQKLHRDMEEATLHFETTSASLKKRHADSLAELEGQVENLQ 1223
Cdd:pfam15818  377 --NENSEMSTEKSENLIIQ--KYNSEQEIREENTKSFCSDTEYRETEKKKGPPVEEIIIEDLQ 435
Mitofilin pfam09731
Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. ...
859-1147 2.16e-03

Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. Mitofilin is enriched in the narrow space between the inner boundary and the outer membranes, where it forms a homotypic interaction and assembles into a large multimeric protein complex. The first 78 amino acids contain a typical amino-terminal-cleavable mitochondrial presequence rich in positive-charged and hydroxylated residues and a membrane anchor domain. In addition, it has three centrally located coiled coil domains.


Pssm-ID: 430783 [Multi-domain]  Cd Length: 618  Bit Score: 42.82  E-value: 2.16e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   859 EEVAGLKEECAQLQKALEKSEFQREELKAKQVSLTQEKNDLILQLQaeqetlanveeqcEWLIKSKIQLEARVKELSERV 938
Cdd:pfam09731  173 AEISREKATDSALQKAEALAEKLKEVINLAKQSEEEAAPPLLDAAP-------------ETPPKLPEHLDNVEEKVEKAQ 239
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   939 EEEEEIN--SELTARGRKLEDEcfELKKEIDDLETMLVKSEKEKRTTEHK-VKNLTEEVEFLNEDISKLNRAAkvvQEAH 1015
Cdd:pfam09731  240 SLAKLVDqyKELVASERIVFQQ--ELVSIFPDIIPVLKEDNLLSNDDLNSlIAHAHREIDQLSKKLAELKKRE---EKHI 314
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1016 QQTLDDLHMEEEKLSSLSKANLKLEQQVDELEGALEQERKarmncerelhklegnLKLNRESMENL---------ESSQR 1086
Cdd:pfam09731  315 ERALEKQKEELDKLAEELSARLEEVRAADEAQLRLEFERE---------------REEIRESYEEKlrtelerqaEAHEE 379
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767926067  1087 HLAEELRKKELEL-----SQMNSKVENEKGLvaqLQKTVKELQTQIKDLKEKLEAerttRAKMERE 1147
Cdd:pfam09731  380 HLKDVLVEQEIELqreflQDIKEKVEEERAG---RLLKLNELLANLKGLEKATSS----HSEVEDE 438
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
1337-1562 2.41e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 42.51  E-value: 2.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1337 SQSALAHALQKAQRDCDLLREQYEEEQEVKAELHRTLSKVNAEMVQWRmKYENNVIQRTEDLEDAKKELAIRLQEAAEAM 1416
Cdd:COG3883     7 AAPTPAFADPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYN-ELQAELEALQAEIDKLQAEIAEAEAEIEERR 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1417 GVANARNASLERARHQLQL--------ELGDALSDLGKVRSAAARlDQKQLQSGKALadwKQKHEESQALLDASQKEVQA 1488
Cdd:COG3883    86 EELGERARALYRSGGSVSYldvllgseSFSDFLDRLSALSKIADA-DADLLEELKAD---KAELEAKKAELEAKLAELEA 161
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767926067 1489 LSTELLKLKNTYEESIVGQE----TLRRENKNLQEEISNLTNQVREGTKNLTEMEKVKKLIEEEKTEVQVTLEETEGA 1562
Cdd:COG3883   162 LKAELEAAKAELEAQQAEQEallaQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA 239
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
1436-1946 2.83e-03

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 42.73  E-value: 2.83e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1436 ELGDALSDLGKVRSAAARLDQKQLQSGKALADWKQKHEESQALLDASQKEVQALSTEL------------LKLKNTYEES 1503
Cdd:TIGR00606  320 ELVDCQRELEKLNKERRLLNQEKTELLVEQGRLQLQADRHQEHIRARDSLIQSLATRLeldgfergpfseRQIKNFHTLV 399
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1504 IVGQEtlrRENKNLQEEISNLTNQVREGTKNLTEmekvkklIEEEKTEVQVTLEETEGALERNESKILHFQLELLEAKAE 1583
Cdd:TIGR00606  400 IERQE---DEAKTAAQLCADLQSKERLKQEQADE-------IRDEKKGLGRTIELKKEILEKKQEELKFVIKELQQLEGS 469
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1584 LERKLSEKDEEIENFRRKQQCTIDSLQSSLDSEAKS----RIEVTRLKKKMEEDLNEMELQLSCANRQVSEATKSLGQLQ 1659
Cdd:TIGR00606  470 SDRILELDQELRKAERELSKAEKNSLTETLKKEVKSlqneKADLDRKLRKLDQEMEQLNHHTTTRTQMEMLTKDKMDKDE 549
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1660 iQIKDLQMQLDDS----------TQLNSD----LKEQVAVAERRNSLLQSELEDLRSLQEQTERGRRLSEEELLEateri 1725
Cdd:TIGR00606  550 -QIRKIKSRHSDEltsllgyfpnKKQLEDwlhsKSKEINQTRDRLAKLNKELASLEQNKNHINNELESKEEQLSS----- 623
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1726 nlfYTQNTSLLSQKKKLEADVARMQKEAEEVVQECQNAEEKAKKAAIEAANLSEELKKKQDTIAHLERTRENMEQTITDL 1805
Cdd:TIGR00606  624 ---YEDKLFDVCGSQDEESDLERLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEFISDL 700
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1806 QKRLAEAEQmalmgsrkQIQKLESRVRELEGELEGEIRRSAEAQRGARRLERCIKELTYQAEEDKKNLSRMQTQMDKLQL 1885
Cdd:TIGR00606  701 QSKLRLAPD--------KLKSTESELKKKEKRRDEMLGLAPGRQSIIDLKEKEIPELRNKLQKVNRDIQRLKNDIEEQET 772
                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767926067  1886 KVQNYKQQVEVAET-QANQYLSKYKKQQHELNEVKERAEVAESQVNKLKIKAREFGKKVQEE 1946
Cdd:TIGR00606  773 LLGTIMPEEESAKVcLTDVTIMERFQMELKDVERKIAQQAAKLQGSDLDRTVQQVNQEKQEK 834
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
859-1138 2.86e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 42.06  E-value: 2.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  859 EEVAGLKEECAQLQKALEKSEFQREELKAKQVSLTQEKNDLILQLQAEQETLANVEEQCEWLIKSKIQLEArvkelserv 938
Cdd:COG4942    27 AELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRA--------- 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  939 eeeeeinseltargrkledecfELKKEIDDLETMLVKSEKEKRTTEHKVKnlteeveFLNEDISKLNRAAKVVQEAHQQT 1018
Cdd:COG4942    98 ----------------------ELEAQKEELAELLRALYRLGRQPPLALL-------LSPEDFLDAVRRLQYLKYLAPAR 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1019 LDDLHMEEEKLSSLSKANLKLEQQVDELEGALEQerkarmncerelhklegnlklnresmenLESSQRHLAEELRKKELE 1098
Cdd:COG4942   149 REQAEELRADLAELAALRAELEAERAELEALLAE----------------------------LEEERAALEALKAERQKL 200
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 767926067 1099 LSQMNSKVENEKGLVAQLQKTVKELQTQIKDLKEKLEAER 1138
Cdd:COG4942   201 LARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAA 240
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1340-1570 2.93e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 42.06  E-value: 2.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1340 ALAHALQKAQRDCDLLREQYEEEQEVKAELHRTLSKVNAEMVQwrmkYENNVIQRTEDLEDAKKELAIRLQEAAEAMGVA 1419
Cdd:COG4942    17 AQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAA----LERRIAALARRIRALEQELAALEAELAELEKEI 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1420 NARNASLERARHQLQlELGDALSDLGKVRSAAARLDQKQLQSGKALADWkqkheeSQALLDASQKEVQALSTELLKLKNT 1499
Cdd:COG4942    93 AELRAELEAQKEELA-ELLRALYRLGRQPPLALLLSPEDFLDAVRRLQY------LKYLAPARREQAEELRADLAELAAL 165
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767926067 1500 YEESIVGQETLRRENKNLQEEISNLTNQVREGTKNLTEMEKVKKLIEEEKTEVQVTLEETEGALERNESKI 1570
Cdd:COG4942   166 RAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEA 236
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
1081-1396 3.00e-03

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 42.19  E-value: 3.00e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1081 LESSQRHLAEELRKKELELSQMNSKVENEKGLVAQLQKTVKELQTQIKDLKEKLEAERTTRAKMERERadltQDLADLNE 1160
Cdd:pfam07888   36 LEECLQERAELLQAQEAANRQREKEKERYKRDREQWERQRRELESRVAELKEELRQSREKHEELEEKY----KELSASSE 111
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1161 RLEEVGGSSLAQLEitkkqetkfqklhrDMEEATLHFETTSASLKKRHADSLAELE---GQVENLQQVKQKLEKDKSDLQ 1237
Cdd:pfam07888  112 ELSEEKDALLAQRA--------------AHEARIRELEEDIKTLTQRVLERETELErmkERAKKAGAQRKEEEAERKQLQ 177
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1238 LEvddLLTRVEQMTRAKANAEKLCTLYEERLHEATAKLDKVTQLANDLAAQKtklwsesgeflRRLEEKEALINQLS--R 1315
Cdd:pfam07888  178 AK---LQQTEEELRSLSKEFQELRNSLAQRDTQVLQLQDTITTLTQKLTTAH-----------RKEAENEALLEELRslQ 243
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1316 EKSNFT-RQIEDLRGQLEkETKSQSALAHA------LQKAQRDCDL--LREQYEEEQEVKAELHRTLSKvNAEMVQWRMK 1386
Cdd:pfam07888  244 ERLNASeRKVEGLGEELS-SMAAQRDRTQAelhqarLQAAQLTLQLadASLALREGRARWAQERETLQQ-SAEADKDRIE 321
                          330
                   ....*....|
gi 767926067  1387 YENNVIQRTE 1396
Cdd:pfam07888  322 KLSAELQRLE 331
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
1006-1165 3.11e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 42.62  E-value: 3.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1006 RAAKVVQEAHQQTLDDLHMEEEKLSSLSKANLKLEQQVDELEGALEQERKARMNCERELHKLEGNLKLNRESMENLESSQ 1085
Cdd:COG1196   651 LEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQL 730
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1086 RHLAEELRKKELELSQMNSKVENEKGL----VAQLQKTVKELQTQIKDL-------KEKLEAERTTRAKMERERADLTQD 1154
Cdd:COG1196   731 EAEREELLEELLEEEELLEEEALEELPeppdLEELERELERLEREIEALgpvnllaIEEYEELEERYDFLSEQREDLEEA 810
                         170
                  ....*....|.
gi 767926067 1155 LADLNERLEEV 1165
Cdd:COG1196   811 RETLEEAIEEI 821
COG4026 COG4026
Uncharacterized conserved protein, contains TOPRIM domain, potential nuclease [General ...
1447-1546 3.15e-03

Uncharacterized conserved protein, contains TOPRIM domain, potential nuclease [General function prediction only];


Pssm-ID: 443204 [Multi-domain]  Cd Length: 287  Bit Score: 41.64  E-value: 3.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1447 VRSAAARLDQKQLQSGKALADWKQKHEESQALLDASQKEVQALSTELLKLKNTYEESIVGQETLRRENKNLQEEISNLTN 1526
Cdd:COG4026   112 IKNAIIRAGLKSLQNIPEYNELREELLELKEKIDEIAKEKEKLTKENEELESELEELREEYKKLREENSILEEEFDNIKS 191
                          90       100
                  ....*....|....*....|
gi 767926067 1527 QVREGTKNLTEMEKvKKLIE 1546
Cdd:COG4026   192 EYSDLKSRFEELLK-KRLLE 210
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
1393-1744 3.22e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 42.42  E-value: 3.22e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1393 QRTEDLEDAKKElaiRLQEAAEAMGVANARNASLERARHQLQLELGdalsdlgkvRSAAARLDQKQLQSGKALADWKQKH 1472
Cdd:pfam17380  288 QQQEKFEKMEQE---RLRQEKEEKAREVERRRKLEEAEKARQAEMD---------RQAAIYAEQERMAMERERELERIRQ 355
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1473 EESQALLDASQKEVQALST------ELLKLKNTYEESIVGQETLRRENKNLQEEisnltNQVREGTKNLTEMEKVKKLIE 1546
Cdd:pfam17380  356 EERKRELERIRQEEIAMEIsrmrelERLQMERQQKNERVRQELEAARKVKILEE-----ERQRKIQQQKVEMEQIRAEQE 430
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1547 EEKT-EVQVTLEETEGALE--RNESKILHFQLELL-EAKAELERKLSEKDEEIENFRRKQQCTIDSLQSSLDSEAKSRIE 1622
Cdd:pfam17380  431 EARQrEVRRLEEERAREMErvRLEEQERQQQVERLrQQEEERKRKKLELEKEKRDRKRAEEQRRKILEKELEERKQAMIE 510
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1623 VTRLKKKMEEdlnEMElqlscanrqvseatkslgqlqiqikdlqmqlDDSTQLNSDLKEQVAVAERRNsllQSELEDLRS 1702
Cdd:pfam17380  511 EERKRKLLEK---EME-------------------------------ERQKAIYEEERRREAEEERRK---QQEMEERRR 553
                          330       340       350       360
                   ....*....|....*....|....*....|....*....|...
gi 767926067  1703 LQEQTergRRLSEEE-LLEATERINLFYTQNTSLLSQKKKLEA 1744
Cdd:pfam17380  554 IQEQM---RKATEERsRLEAMEREREMMRQIVESEKARAEYEA 593
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
1674-1946 3.28e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 42.42  E-value: 3.28e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1674 QLNSDLKEQVAVAERRNSLLQSELEDLRSLQEQTERGRRLSEEELLEATErinlfyTQNTSLLSQKKKLEADVARMQKEA 1753
Cdd:pfam17380  273 QLLHIVQHQKAVSERQQQEKFEKMEQERLRQEKEEKAREVERRRKLEEAE------KARQAEMDRQAAIYAEQERMAMER 346
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1754 EEVVQECQNAEEKAKKAAIEAANLSEELKKkqdtIAHLERTRENMEQTITDLQKRLAEAEQMALMGSRKQiqklesRVRE 1833
Cdd:pfam17380  347 ERELERIRQEERKRELERIRQEEIAMEISR----MRELERLQMERQQKNERVRQELEAARKVKILEEERQ------RKIQ 416
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1834 LEGELEGEIRRSAEA--QRGARRLErcikeltyqaEEDKKNLSRMQTQMDKLQLKVQNYKQQvEVAETQANQYLSKYKKQ 1911
Cdd:pfam17380  417 QQKVEMEQIRAEQEEarQREVRRLE----------EERAREMERVRLEEQERQQQVERLRQQ-EEERKRKKLELEKEKRD 485
                          250       260       270
                   ....*....|....*....|....*....|....*
gi 767926067  1912 QHELNEVKERAEVAESQVNKLKIKAREFGKKVQEE 1946
Cdd:pfam17380  486 RKRAEEQRRKILEKELEERKQAMIEEERKRKLLEK 520
Filament pfam00038
Intermediate filament protein;
1275-1590 3.51e-03

Intermediate filament protein;


Pssm-ID: 459643 [Multi-domain]  Cd Length: 313  Bit Score: 41.83  E-value: 3.51e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1275 LDKVTQLANDLAAQKTKLwsesgeflRRLEEKEAliNQLSREKSNFTRQIEDLRGQLEKETKSQSALAHALQKAQRDCDL 1354
Cdd:pfam00038   17 IDKVRFLEQQNKLLETKI--------SELRQKKG--AEPSRLYSLYEKEIEDLRRQLDTLTVERARLQLELDNLRLAAED 86
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1355 LREQYEEE----QEVKAELHrTLSKVNAEMVQWRMKYENNVIQRTEDLEDAKKelaIRLQEAAEAMGVANARNASLERaR 1430
Cdd:pfam00038   87 FRQKYEDElnlrTSAENDLV-GLRKDLDEATLARVDLEAKIESLKEELAFLKK---NHEEEVRELQAQVSDTQVNVEM-D 161
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1431 HQLQLELGDALSDLGKVRSAAARLDQKQLQsgkalADWKQKHEESQALLDASQKEVQALSTELLKLKNTYeesivgqETL 1510
Cdd:pfam00038  162 AARKLDLTSALAEIRAQYEEIAAKNREEAE-----EWYQSKLEELQQAAARNGDALRSAKEEITELRRTI-------QSL 229
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1511 RRENKNLQEEISNLTNQVREgtknltemekvkklieeektevqvtLEET-EGALERNESKILHFQLELLEAKAELERKLS 1589
Cdd:pfam00038  230 EIELQSLKKQKASLERQLAE-------------------------TEERyELQLADYQELISELEAELQETRQEMARQLR 284

                   .
gi 767926067  1590 E 1590
Cdd:pfam00038  285 E 285
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
947-1558 3.59e-03

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 42.73  E-value: 3.59e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   947 ELTARGRKLEDECFELKKEIDDLETMLVKS-------EKEKR-----TTEHKVKNLTEEVEFLNEDISKLNRAAKVVQE- 1013
Cdd:TIGR01612 1133 ALEEIKKKSENYIDEIKAQINDLEDVADKAisnddpeEIEKKienivTKIDKKKNIYDEIKKLLNEIAEIEKDKTSLEEv 1212
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1014 -----AHQQTLDDLHME---EEKLSS--LSKANLKLEQQVDELEGAlEQERKARMNCERELHKLEGNLKL-NRESMENLE 1082
Cdd:TIGR01612 1213 kginlSYGKNLGKLFLEkidEEKKKSehMIKAMEAYIEDLDEIKEK-SPEIENEMGIEMDIKAEMETFNIsHDDDKDHHI 1291
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1083 SSQRH--LAEELRKKELELSQMNS----------------------------------------KVENEKGLVAQLQKTV 1120
Cdd:TIGR01612 1292 ISKKHdeNISDIREKSLKIIEDFSeesdindikkelqknlldaqkhnsdinlylneianiynilKLNKIKKIIDEVKEYT 1371
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1121 KELQTQIKDLKEKLEAERTTRAKME--------RERADLTQDLADLNERLEEVGGSSLAQLEITKKQETKFQKLHRDMEE 1192
Cdd:TIGR01612 1372 KEIEENNKNIKDELDKSEKLIKKIKddinleecKSKIESTLDDKDIDECIKKIKELKNHILSEESNIDTYFKNADENNEN 1451
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1193 ATLHFETTS-ASLKKRHADSLAELEGQVE---NLQQVKQKLEKDKSdLQLEVDdlltrveqmtRAKANAEKLCTLYEERL 1268
Cdd:TIGR01612 1452 VLLLFKNIEmADNKSQHILKIKKDNATNDhdfNINELKEHIDKSKG-CKDEAD----------KNAKAIEKNKELFEQYK 1520
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1269 HEATAKLDKVTQLANDLAAQKTKlwsesgeflrrlEEKEALINQLSREKSNFTRQIEDLRGQLEKETKSQSALAHALQKa 1348
Cdd:TIGR01612 1521 KDVTELLNKYSALAIKNKFAKTK------------KDSEIIIKEIKDAHKKFILEAEKSEQKIKEIKKEKFRIEDDAAK- 1587
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1349 qrdcdllreqyeEEQEVKAELHRTLSKVNAEMVQWRM----KYENNVIQRTEDLEDAKKELAIRLQEAAEAmgvanarna 1424
Cdd:TIGR01612 1588 ------------NDKSNKAAIDIQLSLENFENKFLKIsdikKKINDCLKETESIEKKISSFSIDSQDTELK--------- 1646
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1425 slerarhqlqlELGDALSDLgkvrsaaarldQKQLQSgkaLADWKQKHEESQALLDASQKEVQALSTELLKLKNTYEESI 1504
Cdd:TIGR01612 1647 -----------ENGDNLNSL-----------QEFLES---LKDQKKNIEDKKKELDELDSEIEKIEIDVDQHKKNYEIGI 1701
                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767926067  1505 VgqETLRRENKNLQEEISNLTNQVREGTKNLTEMEKVKKL--------IEEEKTEVQVTLEE 1558
Cdd:TIGR01612 1702 I--EKIKEIAIANKEEIESIKELIEPTIENLISSFNTNDLegidpnekLEEYNTEIGDIYEE 1761
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1693-1930 3.59e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 42.59  E-value: 3.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1693 LQSELEDLRSLQEQTERGRRlsEEELLEATERINLFYTQNTSLLSQKKKLEA--DVARMQKEAEEVVQECQNaeekakka 1770
Cdd:COG4913   230 LVEHFDDLERAHEALEDARE--QIELLEPIRELAERYAAARERLAELEYLRAalRLWFAQRRLELLEAELEE-------- 299
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1771 aieaanLSEELKKKQDTIAHLERTRENMEQTITDLQKRLAEAEQmalmgsrKQIQKLEsrvreleGELEGEIRRSAEAQR 1850
Cdd:COG4913   300 ------LRAELARLEAELERLEARLDALREELDELEAQIRGNGG-------DRLEQLE-------REIERLERELEERER 359
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1851 GARRLERCIKELTYQAEEDKKNLSRMQTQMDKLQLKVQNYKQQVEVAETQANQYLSKYKKQQHELNEvkERAEVAESQVN 1930
Cdd:COG4913   360 RRARLEALLAALGLPLPASAEEFAALRAEAAALLEALEEELEALEEALAEAEAALRDLRRELRELEA--EIASLERRKSN 437
PRK10246 PRK10246
exonuclease subunit SbcC; Provisional
972-1677 3.87e-03

exonuclease subunit SbcC; Provisional


Pssm-ID: 182330 [Multi-domain]  Cd Length: 1047  Bit Score: 42.48  E-value: 3.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  972 MLVKSEKEKRTTEHKVKNLTEEVEFLNED-ISKLNRAAKVVQEAHQQTLDDLHMEEEKLSSLSKANlKLEQQVDELEGAL 1050
Cdd:PRK10246  188 MVFEQHKSARTELEKLQAQASGVALLTPEqVQSLTASLQVLTDEEKQLLTAQQQQQQSLNWLTRLD-ELQQEASRRQQAL 266
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1051 EQERKARMNCERELHKLEgnLKLNRESMENLESSQRHLAEELRKKELELSQMNSKVENEKGLVAQL----QKTVKELQTQ 1126
Cdd:PRK10246  267 QQALAAEEKAQPQLAALS--LAQPARQLRPHWERIQEQSAALAHTRQQIEEVNTRLQSTMALRARIrhhaAKQSAELQAQ 344
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1127 IKDLKEKLEAE-------------RTTRAKMERERADL---TQDLADLNERLEEVGGSSL--------AQLEITKKQETK 1182
Cdd:PRK10246  345 QQSLNTWLAEHdrfrqwnnelagwRAQFSQQTSDREQLrqwQQQLTHAEQKLNALPAITLtltadevaAALAQHAEQRPL 424
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1183 FQKLhrdmeeATLHfeTTSASLKKRhadsLAELEGQVENLQQVKQKLE----------KDKSDLQLEVDDLLTRVEQMT- 1251
Cdd:PRK10246  425 RQRL------VALH--GQIVPQQKR----LAQLQVAIQNVTQEQTQRNaalnemrqryKEKTQQLADVKTICEQEARIKd 492
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1252 ----RAKANAEKLCTLYEERLHEATAKLDKVTQLAN----DLAAQKTKLWSESGEFLRrlEEKEALINQLSREKSNFTRQ 1323
Cdd:PRK10246  493 leaqRAQLQAGQPCPLCGSTSHPAVEAYQALEPGVNqsrlDALEKEVKKLGEEGAALR--GQLDALTKQLQRDESEAQSL 570
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1324 IEDLRGQLEKETKSQSALAHALQKAQRDCDLLREQYEEEQEVK--AELHRTLSKVNAEMVQWRmKYENNVIQRTEDLEDA 1401
Cdd:PRK10246  571 RQEEQALTQQWQAVCASLNITLQPQDDIQPWLDAQEEHERQLRllSQRHELQGQIAAHNQQII-QYQQQIEQRQQQLLTA 649
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1402 KKELAIRLQEAAEAMGVANAR--NASLERARHQLQLELGDALSDLGKVRSAAARLDQKQLQSGKALAD-WKQKHEESQAL 1478
Cdd:PRK10246  650 LAGYALTLPQEDEEASWLATRqqEAQSWQQRQNELTALQNRIQQLTPLLETLPQSDDLPHSEETVALDnWRQVHEQCLSL 729
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1479 ldasQKEVQALSTELLKLKNTYEESIVgQETLRRENKNLQEEISNLTNQVREGTknLTEMEKVKKLIEEEKTEVQVTLEE 1558
Cdd:PRK10246  730 ----HSQLQTLQQQDVLEAQRLQKAQA-QFDTALQASVFDDQQAFLAALLDEET--LTQLEQLKQNLENQRQQAQTLVTQ 802
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1559 TEGALERNeskilhfqlelleakaelerklsekdeeienfrrkQQCTIDSLQSSLDSEaKSRIEVTRLKKKMEEDLN--- 1635
Cdd:PRK10246  803 TAQALAQH-----------------------------------QQHRPDGLDLTVTVE-QIQQELAQLAQQLRENTTrqg 846
                         730       740       750       760
                  ....*....|....*....|....*....|....*....|..
gi 767926067 1636 EMELQLscanRQVSEATKSLGQLQIQIKDLQMQLDDSTQLNS 1677
Cdd:PRK10246  847 EIRQQL----KQDADNRQQQQALMQQIAQATQQVEDWGYLNS 884
ATG17_like pfam04108
Autophagy protein ATG17-like domain; This domain is found in the autophagy-related proteins ...
1076-1375 3.88e-03

Autophagy protein ATG17-like domain; This domain is found in the autophagy-related proteins ATG17 and ATG11, conserved across eukaryotes. ATG17 forms a complex with ATG29 and ATG31, critical for both PAS (preautophagosomal structure) formation and autophagy. Together with ATG13, it is required for ATG1 kinase activation. ATG11 is a scaffold protein required for the cytoplasm-to-vacuole targeting (Cvt) pathway during starvation and to recruit ATG proteins to the pre-autophagosome. It is also required for ATG1 kinase activation. In many eukaryotes, ATG11 (the orthologue in mammals is RB1-inducible coiled-coil protein 1 (RB1CC1) and in S. pombe is Taz1-interacting factor 1 (taf1)) is essential for bulk autophagy, except in S.cerevisiae. ATG17 and ATG11 are large similar proteins, both predicted to be almost entirely helical, containing conserved coiled-coil regions and lack obvious functional motifs.


Pssm-ID: 427715 [Multi-domain]  Cd Length: 360  Bit Score: 41.60  E-value: 3.88e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1076 ESMENLESSQRHLAEELRKKELELSQMNSKVENekgLVAQLQKTVKELQTQIKDLKEKLEaerttraKMERERADLTQDL 1155
Cdd:pfam04108    3 SSAQDLCRWANELLTDARSLLEELVVLLAKIAF---LRRGLSVQLANLEKVREGLEKVLN-------ELKKDFKQLLKDL 72
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1156 ADLNERLEEVggsslaqLEITKKQETKFQKLHRDMEEATLH-F--ETTSASLKKRHADSLAELEGQVENLQQVKQKLEKD 1232
Cdd:pfam04108   73 DAALERLEET-------LDKLRNTPVEPALPPGEEKQKTLLdFidEDSVEILRDALKELIDELQAAQESLDSDLKRFDDD 145
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1233 KSDLQLEVDDLLTRveqmTRAKANAEKLCTLYEERLHEATAKLDKVTQLANDLAAQKTKLWSESGEFLRRLEEKEALINQ 1312
Cdd:pfam04108  146 LRDLQKELESLSSP----SESISLIPTLLKELESLEEEMASLLESLTNHYDQCVTAVKLTEGGRAEMLEVLENDARELDD 221
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767926067  1313 LSREKSNFTRQIEDLRGQLEKETKSQSALAHALQKAQRDCDLLREQYEEEQEVKAELHRTLSK 1375
Cdd:pfam04108  222 VVPELQDRLDEMENNYERLQKLLEQKNSLIDELLSALQLIAEIQSRLPEYLAALKEFEERWEE 284
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1144-1361 3.92e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 42.31  E-value: 3.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1144 MERERADLTQDLADLNERLEEVGgsslAQLEITKKQETKFQKLHR--DMEEATLHFETTSASLKKRHADSLAELEGQVEN 1221
Cdd:COG3206   166 LELRREEARKALEFLEEQLPELR----KELEEAEAALEEFRQKNGlvDLSEEAKLLLQQLSELESQLAEARAELAEAEAR 241
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1222 LQQVKQKLEKDKSDLQLEVDDllTRVEQMTRAKANAEKLCTLYEERLheaTAKLDKVTQLANDLAAQKTKLWSESGeflR 1301
Cdd:COG3206   242 LAALRAQLGSGPDALPELLQS--PVIQQLRAQLAELEAELAELSARY---TPNHPDVIALRAQIAALRAQLQQEAQ---R 313
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1302 RLEEKEALINQLSREKSNFTRQIEDLRGQLeketKSQSALAHALQKAQRDCDLLREQYEE 1361
Cdd:COG3206   314 ILASLEAELEALQAREASLQAQLAQLEARL----AELPELEAELRRLEREVEVARELYES 369
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
859-1305 3.93e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 42.21  E-value: 3.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  859 EEVAGLKEECAQLQKALEKSEFQREELKAKQ--------VSLTQEKNDLILQLQAEQETLANVEEQCEWL----IKSKIQ 926
Cdd:COG4913   302 AELARLEAELERLEARLDALREELDELEAQIrgnggdrlEQLEREIERLERELEERERRRARLEALLAALglplPASAEE 381
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  927 LEARVKELSERVEEEEEINSELTARGRKLEDECFELKKEIDDLetmlvksEKEKRTTEHKVKNLTEEVEF----LNEDIS 1002
Cdd:COG4913   382 FAALRAEAAALLEALEEELEALEEALAEAEAALRDLRRELREL-------EAEIASLERRKSNIPARLLAlrdaLAEALG 454
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1003 KLNRAAKVVQEAHQQTLDD----------LH-------MEEEKLSSLSKA--NLKLEQQVDELEGALEQERKARMNCERE 1063
Cdd:COG4913   455 LDEAELPFVGELIEVRPEEerwrgaiervLGgfaltllVPPEHYAAALRWvnRLHLRGRLVYERVRTGLPDPERPRLDPD 534
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1064 --LHKLEG---------NLKLNR-------ESMENLESSQRHLAEE-LRKKELELSQMNSKVENEKGLV---------AQ 1115
Cdd:COG4913   535 slAGKLDFkphpfrawlEAELGRrfdyvcvDSPEELRRHPRAITRAgQVKGNGTRHEKDDRRRIRSRYVlgfdnraklAA 614
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1116 LQKTVKELQTQIKDLKEKLEAERTTRAKMeRERADLTQDLADLNERLEEVGGsslAQLEITKKQETKfqklhRDMEEATL 1195
Cdd:COG4913   615 LEAELAELEEELAEAEERLEALEAELDAL-QERREALQRLAEYSWDEIDVAS---AEREIAELEAEL-----ERLDASSD 685
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1196 HFETtsasLKKRhadsLAELEGQVENLQQVKQKLEKDKSDLQLEVDDLLTRVEQMTRAKANAEKLCTLY-----EERLHE 1270
Cdd:COG4913   686 DLAA----LEEQ----LEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLElrallEERFAA 757
                         490       500       510
                  ....*....|....*....|....*....|....*...
gi 767926067 1271 ATAKL---DKVTQLANDLAAQKTKLWSESGEFLRRLEE 1305
Cdd:COG4913   758 ALGDAverELRENLEERIDALRARLNRAEEELERAMRA 795
CusB_dom_1 pfam00529
Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli ...
1039-1176 4.35e-03

Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli can be divided into four different domains, the first three domains of the protein are mostly beta-strands and the fourth forms an all alpha-helical domain. This entry represents the first beta-domain (domain 1) of CusB and it is formed by the N and C-terminal ends of the polypeptide (residues 89-102 and 324-385). CusB is part of the copper-transporting efflux system CusCFBA. This domain can also be found in other membrane-fusion proteins, such as HlyD, MdtN, MdtE and AaeA. HlyD is a component of the prototypical alpha-haemolysin (HlyA) bacterial type I secretion system, along with the other components HlyB and TolC. HlyD is anchored in the cytoplasmic membrane by a single transmembrane domain and has a large periplasmic domain within the carboxy-terminal 100 amino acids, HlyB and HlyD form a stable complex that binds the recombinant protein bearing a C-terminal HlyA signal sequence and ATP in the cytoplasm. HlyD, HlyB and TolC combine to form the three-component ABC transporter complex that forms a trans-membrane channel or pore through which HlyA can be transferred directly to the extracellular medium. Cutinase has been shown to be transported effectively through this pore.


Pssm-ID: 425733 [Multi-domain]  Cd Length: 322  Bit Score: 41.25  E-value: 4.35e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1039 LEQQVDELEGALEQERKARMNCERE---LHKLEGNLKLNRESMENLESSQRHLAEELRKKELELSQMNS----------- 1104
Cdd:pfam00529   56 YQAALDSAEAQLAKAQAQVARLQAEldrLQALESELAISRQDYDGATAQLRAAQAAVKAAQAQLAQAQIdlarrrvlapi 135
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767926067  1105 ------KVENEKGLVAQLQKTVKELQTQI-KDLKEKLEAERTTRAKMERERADLTQDLADLNERLEEVgGSSLAQLEIT 1176
Cdd:pfam00529  136 ggisreSLVTAGALVAQAQANLLATVAQLdQIYVQITQSAAENQAEVRSELSGAQLQIAEAEAELKLA-KLDLERTEIR 213
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1393-1621 4.36e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 41.67  E-value: 4.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1393 QRTEDLEDAKKELAIRLQEAAEAMGVANARNASLERARHQLQLELGDALSDL----GKVRSAAARLDQKQLQSGKALADW 1468
Cdd:COG4942    20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIraleQELAALEAELAELEKEIAELRAEL 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1469 KQKHEESQALLDASQKEVQALSTELLKLKNTYEESIVGQETLRRENKNLQEEISNLTNQVREGTKNLTEMEKVKKLIEEE 1548
Cdd:COG4942   100 EAQKEELAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELEAL 179
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767926067 1549 KTEVQVTLEETEGALERNESKILHFQLELLEAK---AELERKLSEKDEEIENFRRKQQCTIDSLQSSLDSEAKSRI 1621
Cdd:COG4942   180 LAELEEERAALEALKAERQKLLARLEKELAELAaelAELQQEAEELEALIARLEAEAAAAAERTPAAGFAALKGKL 255
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
894-1250 4.48e-03

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 41.80  E-value: 4.48e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   894 QEKNDLilqLQAEQETLANVEEQCEWLIKSKIQLEARVKELSERVEEEEEI-------NSELTARGRKLEDECFELKKEI 966
Cdd:pfam07888   41 QERAEL---LQAQEAANRQREKEKERYKRDREQWERQRRELESRVAELKEElrqsrekHEELEEKYKELSASSEELSEEK 117
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   967 DDLETMLVKSEKEKRTTEHKVKNLTE-------EVEFLNEDISKLNRAAKVVQEAHQQTLDDLHMEEEKLSSLSKANLKL 1039
Cdd:pfam07888  118 DALLAQRAAHEARIRELEEDIKTLTQrvleretELERMKERAKKAGAQRKEEEAERKQLQAKLQQTEEELRSLSKEFQEL 197
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1040 EQQVDELEGALEQERKARMNCERELHKLEGNLKLNRESMENLESSQRHLAEELRKKEL---ELSQMNSKVENEKGLVAQL 1116
Cdd:pfam07888  198 RNSLAQRDTQVLQLQDTITTLTQKLTTAHRKEAENEALLEELRSLQERLNASERKVEGlgeELSSMAAQRDRTQAELHQA 277
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1117 QKTVKELQTQIKDLKEKLEAERTTRAKmerERADLTQDLADLNERLEevggsslaqleitkKQETKFQKLHRDMEEATLH 1196
Cdd:pfam07888  278 RLQAAQLTLQLADASLALREGRARWAQ---ERETLQQSAEADKDRIE--------------KLSAELQRLEERLQEERME 340
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 767926067  1197 FETTSASLKKRHADSLAELEGQVENLQQVKQKL---EKDKSDLQLEVDDLLTRVEQM 1250
Cdd:pfam07888  341 REKLEVELGREKDCNRVQLSESRRELQELKASLrvaQKEKEQLQAEKQELLEYIRQL 397
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
1465-1711 4.56e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 41.74  E-value: 4.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1465 LADWKQKHEESQALLDASQKEVQALSTELLKLKNTYEESIVGQETLRRENKNLQEEISNLTNQVREGTKNLTEMEKVKKL 1544
Cdd:COG3883    18 IQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGERARALYR 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1545 IEEEKTEVQVTL--EETEGALERNE--SKILHFQLELLEAKAELERKLSEKDEEIENfrrkqqctidslqssldseaksr 1620
Cdd:COG3883    98 SGGSVSYLDVLLgsESFSDFLDRLSalSKIADADADLLEELKADKAELEAKKAELEA----------------------- 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1621 ievtrLKKKMEEDLNEMELQLSCANRQVSEATKSLGQLQIQIKDLQMQLDdstqlnsDLKEQVAVAERRNSLLQSELEDL 1700
Cdd:COG3883   155 -----KLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLA-------ELEAELAAAEAAAAAAAAAAAAA 222
                         250
                  ....*....|.
gi 767926067 1701 RSLQEQTERGR 1711
Cdd:COG3883   223 AAAAAAAAAAA 233
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
918-1945 4.81e-03

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 42.35  E-value: 4.81e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   918 EWLIKSKI--QLEARVKELSERVEEEEEINSELTARGRKLEDECFELKKEIDDLETMLVKSEKE-------KRTTEHKVK 988
Cdd:TIGR01612  531 DQNIKAKLykEIEAGLKESYELAKNWKKLIHEIKKELEEENEDSIHLEKEIKDLFDKYLEIDDEiiyinklKLELKEKIK 610
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   989 NLTEEVEFLNEDISklnraAKVVQEAHQQTLDDL----------HME-EEKLSSLSKANLK--LEQQVDELEGALEQERK 1055
Cdd:TIGR01612  611 NISDKNEYIKKAID-----LKKIIENNNAYIDELakispyqvpeHLKnKDKIYSTIKSELSkiYEDDIDALYNELSSIVK 685
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1056 armncERELHKLEGNLKLnresmENLESSQRHLAEELRKKELELSQMN-SKVENEKGlvaQLQKTVKELQTQI-----KD 1129
Cdd:TIGR01612  686 -----ENAIDNTEDKAKL-----DDLKSKIDKEYDKIQNMETATVELHlSNIENKKN---ELLDIIVEIKKHIhgeinKD 752
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1130 LKEKLEAERTTRAKMERERADLTQDLADLN---ERLEEVGGSSLAQLEI--TKKQETKfqklhRDMEEATLHFETTSASl 1204
Cdd:TIGR01612  753 LNKILEDFKNKEKELSNKINDYAKEKDELNkykSKISEIKNHYNDQINIdnIKDEDAK-----QNYDKSKEYIKTISIK- 826
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1205 kkrhADSLAELEGQVENLQqvkqklekdksdlqlevDDLLTRVEQMTrakaNAEKLCTLYEERLHEATAKLdkVTQLAND 1284
Cdd:TIGR01612  827 ----EDEIFKIINEMKFMK-----------------DDFLNKVDKFI----NFENNCKEKIDSEHEQFAEL--TNKIKAE 879
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1285 LAAQKTKLWSesgeflRRLEEKEALINQLSREKSNFTRQIEDLRgQLEKETKSQSALAHALQKAQRDCDLLREQYeeEQE 1364
Cdd:TIGR01612  880 ISDDKLNDYE------KKFNDSKSLINEINKSIEEEYQNINTLK-KVDEYIKICENTKESIEKFHNKQNILKEIL--NKN 950
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1365 VKaelhrTLSKVNAEMVQWRMKYENNVIQRTEDLEDAKKELAIRLQEaaeamgvanARNASLERARHQLQLELGDalsdl 1444
Cdd:TIGR01612  951 ID-----TIKESNLIEKSYKDKFDNTLIDKINELDKAFKDASLNDYE---------AKNNELIKYFNDLKANLGK----- 1011
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1445 GKVRSAAARLDQKQlqsgKALADWKQKHEESQAllDASQKEVqALSTELLKLKNTYEESIvgQETLRRENKNLQEEIS-N 1523
Cdd:TIGR01612 1012 NKENMLYHQFDEKE----KATNDIEQKIEDANK--NIPNIEI-AIHTSIYNIIDEIEKEI--GKNIELLNKEILEEAEiN 1082
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1524 LT--NQVREGTKNLTEMEKVKklieEEKTEVQVTLEETEGALERNESKILHFQLELLEAKAELERKLSEKDEEIENFRRK 1601
Cdd:TIGR01612 1083 ITnfNEIKEKLKHYNFDDFGK----EENIKYADEINKIKDDIKNLDQKIDHHIKALEEIKKKSENYIDEIKAQINDLEDV 1158
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1602 QQCTIdSLQSSLDSEAKSRIEVTRLKKKmEEDLNEMELQLScanrQVSEATKSLGQLQiQIKDLQMQLDDStqLNSDLKE 1681
Cdd:TIGR01612 1159 ADKAI-SNDDPEEIEKKIENIVTKIDKK-KNIYDEIKKLLN----EIAEIEKDKTSLE-EVKGINLSYGKN--LGKLFLE 1229
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1682 QVAVAERRNS----LLQSELEDLRSLQEQTERGRRLSEEELLEATER--INLFYTQNTSLLSQKKKLEADVARMQKEAEE 1755
Cdd:TIGR01612 1230 KIDEEKKKSEhmikAMEAYIEDLDEIKEKSPEIENEMGIEMDIKAEMetFNISHDDDKDHHIISKKHDENISDIREKSLK 1309
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1756 VVQECQNAEEKAKKAAIEAANLSEELKKKQDTIAHLERTR--------ENMEQTITDLQKRLAEAEQM------ALMGSR 1821
Cdd:TIGR01612 1310 IIEDFSEESDINDIKKELQKNLLDAQKHNSDINLYLNEIAniynilklNKIKKIIDEVKEYTKEIEENnknikdELDKSE 1389
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1822 KQIQKLESRVrelegeLEGEIRRSAEAQRGARRLERCIKELTY-----------------QAEEDKKNLSRMQTQMDKLQ 1884
Cdd:TIGR01612 1390 KLIKKIKDDI------NLEECKSKIESTLDDKDIDECIKKIKElknhilseesnidtyfkNADENNENVLLLFKNIEMAD 1463
                         1050      1060      1070      1080      1090      1100
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767926067  1885 LKVQN-YKQQVEVAETQANQYLSKYKKQQHELNEVKERAEVAESQVNKLKIKAREFGKKVQE 1945
Cdd:TIGR01612 1464 NKSQHiLKIKKDNATNDHDFNINELKEHIDKSKGCKDEADKNAKAIEKNKELFEQYKKDVTE 1525
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
1721-1928 5.29e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 41.35  E-value: 5.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1721 ATERINLFYTQNTSLLSQKKKLEADVARMQKEAEEVVQECQNAEEKAKKAAIEAANLSEELKKKQdtiAHLERTRENMEQ 1800
Cdd:COG3883    14 ADPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAE---AEIEERREELGE 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1801 TITDLQKRLAEAEQM-ALMGSrKQIQKLESRVrelegeleGEIRRSAEAQRgaRRLERcIKELTYQAEEDKKNLSRMQTQ 1879
Cdd:COG3883    91 RARALYRSGGSVSYLdVLLGS-ESFSDFLDRL--------SALSKIADADA--DLLEE-LKADKAELEAKKAELEAKLAE 158
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 767926067 1880 MDKLQLKVQNYKQQVEVAETQANQYLSKYKKQQHELNEVKERAEVAESQ 1928
Cdd:COG3883   159 LEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAA 207
PRK09039 PRK09039
peptidoglycan -binding protein;
1210-1382 5.29e-03

peptidoglycan -binding protein;


Pssm-ID: 181619 [Multi-domain]  Cd Length: 343  Bit Score: 41.10  E-value: 5.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1210 DSLAELEGQVENLQQvKQKLEKD-KSDLQLEVDDLLTRVEQmtrAKANAEKLCTLYEERLHEATAKLDKVTQLANDLAAQ 1288
Cdd:PRK09039   53 SALDRLNSQIAELAD-LLSLERQgNQDLQDSVANLRASLSA---AEAERSRLQALLAELAGAGAAAEGRAGELAQELDSE 128
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1289 KTklwsESGEFLRRLEekeaLINQlsreksnftrQIEDLRGQLeketksqSALAHALQKAqrdcdllrEQYEEEQEVK-A 1367
Cdd:PRK09039  129 KQ----VSARALAQVE----LLNQ----------QIAALRRQL-------AALEAALDAS--------EKRDRESQAKiA 175
                         170
                  ....*....|....*
gi 767926067 1368 ELHRTLSKVNAEMVQ 1382
Cdd:PRK09039  176 DLGRRLNVALAQRVQ 190
HOOK pfam05622
HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from ...
888-1253 5.58e-03

HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from different eukaryotic organizms. The different members of the human gene family are HOOK1, HOOK2 and HOOK3. Different domains have been identified in the three human HOOK proteins, and it was demonstrated that the highly conserved NH2-domain mediates attachment to microtubules, whereas this central coiled-coil motif mediates homodimerization and the more divergent C-terminal domains are involved in binding to specific organelles (organelle-binding domains). It has been demonstrated that endogenous HOOK3 binds to Golgi membranes, whereas both HOOK1 and HOOK2 are localized to discrete but unidentified cellular structures. In mice the Hook1 gene is predominantly expressed in the testis. Hook1 function is necessary for the correct positioning of microtubular structures within the haploid germ cell. Disruption of Hook1 function in mice causes abnormal sperm head shape and fragile attachment of the flagellum to the sperm head. This entry includes the central coiled-coiled domain and the divergent C-terminal domain.


Pssm-ID: 461694 [Multi-domain]  Cd Length: 528  Bit Score: 41.60  E-value: 5.58e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   888 KQVSLTQEKNDLILQ----LQAEQETLANVEEQCEWLIKSKIQLEARVKELSERVEEEEEINSELTARGRKLEDECFELK 963
Cdd:pfam05622   21 QQVSLLQEEKNSLQQenkkLQERLDQLESGDDSGTPGGKKYLLLQKQLEQLQEENFRLETARDDYRIKCEELEKEVLELQ 100
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067   964 KEIDDL-----ETMLVKSEKEK-RTTEHKVKNLTEEVEFLN---EDISKLNRAAKVVQEAH----QQTLDdlHMEEEKLS 1030
Cdd:pfam05622  101 HRNEELtslaeEAQALKDEMDIlRESSDKVKKLEATVETYKkklEDLGDLRRQVKLLEERNaeymQRTLQ--LEEELKKA 178
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1031 SLSKANLKL-EQQVDELEGALEQERKARMNCERELHKLEGN---LKLNRESMENLESSQRHLAEELRKKELELSQMNSKV 1106
Cdd:pfam05622  179 NALRGQLETyKRQVQELHGKLSEESKKADKLEFEYKKLEEKleaLQKEKERLIIERDTLRETNEELRCAQLQQAELSQAD 258
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1107 ENEKGLVAQLQKTVKELQ-TQIKDLKEKLEAE----RTTRAKMERER-ADLTQDLADLNERLEEVGGSSLAQLEITKKQE 1180
Cdd:pfam05622  259 ALLSPSSDPGDNLAAEIMpAEIREKLIRLQHEnkmlRLGQEGSYRERlTELQQLLEDANRRKNELETQNRLANQRILELQ 338
                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767926067  1181 TKFQKLHRDMEEATLHFETTSASLKK--RHADSLAELEGQVENLQQVKQKLEKD-KSDLQLEVDDL---LTRVEQMTRA 1253
Cdd:pfam05622  339 QQVEELQKALQEQGSKAEDSSLLKQKleEHLEKLHEAQSELQKKKEQIEELEPKqDSNLAQKIDELqeaLRKKDEDMKA 417
mukB PRK04863
chromosome partition protein MukB;
859-1224 5.94e-03

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 41.87  E-value: 5.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  859 EEVAGLKEECAQLQKALEKSEFQREELKAKQVSLTQEKNDLILQLQAEQETLANV------EEQCEWLIKSKIQLEARVK 932
Cdd:PRK04863  286 EEALELRRELYTSRRQLAAEQYRLVEMARELAELNEAESDLEQDYQAASDHLNLVqtalrqQEKIERYQADLEELEERLE 365
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  933 ELSERVEEEEEINSELTARGRKLEDECFELKKEIDDLETMLvkSEKEKRTTE-HKVKNLTEEVEFLNEDISKLNRAAKVV 1011
Cdd:PRK04863  366 EQNEVVEEADEQQEENEARAEAAEEEVDELKSQLADYQQAL--DVQQTRAIQyQQAVQALERAKQLCGLPDLTADNAEDW 443
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1012 QE---AHQQTLDD-LHMEEEKLSSLSKANlkleqqvDELEGALEQERKARMNCERELHKLEGnlklnRESMENLESsQRH 1087
Cdd:PRK04863  444 LEefqAKEQEATEeLLSLEQKLSVAQAAH-------SQFEQAYQLVRKIAGEVSRSEAWDVA-----RELLRRLRE-QRH 510
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1088 LAEELRKKELELSQMNSKVENEKGLVAQLQKTVK-----------------ELQTQIKDLKEKLEAERTTRAKMERERAD 1150
Cdd:PRK04863  511 LAEQLQQLRMRLSELEQRLRQQQRAERLLAEFCKrlgknlddedeleqlqeELEARLESLSESVSEARERRMALRQQLEQ 590
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1151 LTQDLADL----------NERLEEVGGSSLAQLEITKKQETKFQKLHRDMEEATLHfettsaslKKRHADSLAELEGQVE 1220
Cdd:PRK04863  591 LQARIQRLaarapawlaaQDALARLREQSGEEFEDSQDVTEYMQQLLERERELTVE--------RDELAARKQALDEEIE 662

                  ....
gi 767926067 1221 NLQQ 1224
Cdd:PRK04863  663 RLSQ 666
PLN02939 PLN02939
transferase, transferring glycosyl groups
1389-1637 6.16e-03

transferase, transferring glycosyl groups


Pssm-ID: 215507 [Multi-domain]  Cd Length: 977  Bit Score: 41.81  E-value: 6.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1389 NNVIQRTEDLEDAKKELAIRLQEAAEAMGVANARNASLERARHQLQLELGDAL----SDLGKVRSAAARLD--------- 1455
Cdd:PLN02939  159 EKILTEKEALQGKINILEMRLSETDARIKLAAQEKIHVEILEEQLEKLRNELLirgaTEGLCVHSLSKELDvlkeenmll 238
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1456 QKQLQSGKALADWKQKHEES-------QALLDASQKEVQ----ALSTELLKLkntyeeSIVGQETLRRENKNLQEEISNL 1524
Cdd:PLN02939  239 KDDIQFLKAELIEVAETEERvfklekeRSLLDASLRELEskfiVAQEDVSKL------SPLQYDCWWEKVENLQDLLDRA 312
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1525 TNQVREGTKNLTEMEKVKKLIEEektevqvtLEETEGalERNESKILHFQLELLEAKAE-LERKLSEKDEEIENFRRKQQ 1603
Cdd:PLN02939  313 TNQVEKAALVLDQNQDLRDKVDK--------LEASLK--EANVSKFSSYKVELLQQKLKlLEERLQASDHEIHSYIQLYQ 382
                         250       260       270
                  ....*....|....*....|....*....|....
gi 767926067 1604 CTIDSLQSSLdseaKSRIEVTRlKKKMEEDLNEM 1637
Cdd:PLN02939  383 ESIKEFQDTL----SKLKEESK-KRSLEHPADDM 411
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
1255-1415 6.27e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 40.29  E-value: 6.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1255 ANAEKLCTLYEerLHEATAKLDKVTQLANDLAAQKTKLWSESGEFLRRLEEKEALINQLSREKSNFTRQIEDLRGQLEKE 1334
Cdd:COG1579     1 AMPEDLRALLD--LQELDSELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKY 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1335 TKSQS---------ALAHALQKAQRDCDLLREQYEEEQEVKAELHRTLSKVNAEMVQWRMKYENNVIQRTEDLEDAKKEL 1405
Cdd:COG1579    79 EEQLGnvrnnkeyeALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAEL 158
                         170
                  ....*....|
gi 767926067 1406 AIRLQEAAEA 1415
Cdd:COG1579   159 EELEAEREEL 168
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
954-1110 6.50e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 40.97  E-value: 6.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  954 KLEDECFELKKEIDDLETMLVKSEKEKRTTEHKVKNLTEEVEFLNEDISKLNRAAK----------VVQEAhqQTLDDLH 1023
Cdd:COG3883    41 ALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGERARALYrsggsvsyldVLLGS--ESFSDFL 118
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1024 MEEEKLSSLSKANLKLEQQVDELEGALEQERKARMNCERELHKLEGNLKLNRESMENLESSQRHLAEELRKKELELSQMN 1103
Cdd:COG3883   119 DRLSALSKIADADADLLEELKADKAELEAKKAELEAKLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQL 198

                  ....*..
gi 767926067 1104 SKVENEK 1110
Cdd:COG3883   199 AELEAEL 205
CAGE1 pfam15066
Cancer-associated gene protein 1 family; CAGE-1 is a family of proteins overexpressed in ...
1076-1231 6.52e-03

Cancer-associated gene protein 1 family; CAGE-1 is a family of proteins overexpressed in tumour tissues compared with surrounding tissues. CAGE-1 gene showed testis-specific expression among normal tissues and displayed wide expression in a variety of cancer cell lines and cancer tissues. CAGE-1 is predominantly expressed during post-meiotic stages. It localizes to the acrosomal matrix and acrosomal granule showing it to be a component of the acrosome of mammalian spermatids and spermatozoa.


Pssm-ID: 464481  Cd Length: 528  Bit Score: 41.36  E-value: 6.52e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1076 ESMENLESSQRHLA--EELRKKELELSQMNSKVENEKGLVAQLQKTVKELQTQ----------IKDLKEKLEAERTTRAK 1143
Cdd:pfam15066  302 QSFESLQPLEEDMAlnEVLQKLKHTNRKQQMQIQDLQCSNLYLEKKVKELQMKitkqqvfvdiINKLKENVEELIEDKYN 381
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1144 MERERADLTQDLADLNE-------RLEEVGGSSLA-QLEItKKQETKFQKLH-RDMEEatLHFETTSASLKKRHADSLAE 1214
Cdd:pfam15066  382 VILEKNDINKTLQNLQEilantqkHLQESRKEKETlQLEL-KKIKVNYVHLQeRYITE--MQQKNKSVSQCLEMDKTLSK 458
                          170
                   ....*....|....*..
gi 767926067  1215 LEGQVENLQQVKQKLEK 1231
Cdd:pfam15066  459 KEEEVERLQQLKGELEK 475
Lebercilin pfam15619
Ciliary protein causing Leber congenital amaurosis disease; Lebercilin is a family of ...
1016-1233 6.55e-03

Ciliary protein causing Leber congenital amaurosis disease; Lebercilin is a family of eukaryotic ciliary proteins. Mutations in the gene, LCA5, are implicated in the disease Leber congenital amaurosis. In photoreceptors, lebercilin is uniquely localized at the cilium that bridges the inner and outer segments. Lebercilin functions as an integral element of selective protein transport through photoreceptor cilia. Lebercilin specifically interacts with the intraflagellar transport (IFT), and disruption of IFT can lead to Leber congenital amaurosis.


Pssm-ID: 464776 [Multi-domain]  Cd Length: 193  Bit Score: 39.89  E-value: 6.55e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1016 QQTLDDLHMeeeKLSSLSKANLKLEQQVDELEGALEQERKARMNCERELHKLEGNLKLNRESMENLESSQRHLAEELRKK 1095
Cdd:pfam15619   17 QNELAELQS---KLEELRKENRLLKRLQKRQEKALGKYEGTESELPQLIARHNEEVRVLRERLRRLQEKERDLERKLKEK 93
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067  1096 ELELSQMNSKVenekglvAQLQKTVKElqtqiKDLkekleaerttrakmeRERADLTQDLADLNERLEEvggsslaqlei 1175
Cdd:pfam15619   94 EAELLRLRDQL-------KRLEKLSED-----KNL---------------AEREELQKKLEQLEAKLED----------- 135
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 767926067  1176 tkkQETKFQKLHRDMEEATLHFETTSASLKKRHADSLAELEGQVENLQQVKQKL-EKDK 1233
Cdd:pfam15619  136 ---KDEKIQDLERKLELENKSFRRQLAAEKKKHKEAQEEVKILQEEIERLQQKLkEKER 191
PRK01156 PRK01156
chromosome segregation protein; Provisional
1606-1934 8.35e-03

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 41.04  E-value: 8.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1606 IDSLQSSLDSeakSRIEVTRLKKKMEED---LNEMELQLSCANRQVSEATKSLGQLQIQIKDLQMQLDDSTQLNSDLKEQ 1682
Cdd:PRK01156  185 IDYLEEKLKS---SNLELENIKKQIADDeksHSITLKEIERLSIEYNNAMDDYNNLKSALNELSSLEDMKNRYESEIKTA 261
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1683 vavaerrNSLLQSELEDLRSLQEQTERGRRLSEEELLEATERINLFYTQNTSLLSQKKKLEADVARMQKEAE-----EVV 1757
Cdd:PRK01156  262 -------ESDLSMELEKNNYYKELEERHMKIINDPVYKNRNYINDYFKYKNDIENKKQILSNIDAEINKYHAiikklSVL 334
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1758 QECQNAEEKAKKAAIEAANLSEELKKKQD-------TIAHLERTRENMEQTITDLQKRLAEAEQMALMGS---------- 1820
Cdd:PRK01156  335 QKDYNDYIKKKSRYDDLNNQILELEGYEMdynsylkSIESLKKKIEEYSKNIERMSAFISEILKIQEIDPdaikkelnei 414
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1821 RKQIQKLESRV------RELEGELEGEIRRSAEAQRG--------------------------ARRLERCIKELTYQA-- 1866
Cdd:PRK01156  415 NVKLQDISSKVsslnqrIRALRENLDELSRNMEMLNGqsvcpvcgttlgeeksnhiinhynekKSRLEEKIREIEIEVkd 494
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1867 -EEDKKNLSRMQTQMDKLQL-KVQNYKQQVEVAETQanqyLSKYKKQQHELNEVKERAEVAESQVNKLKI 1934
Cdd:PRK01156  495 iDEKIVDLKKRKEYLESEEInKSINEYNKIESARAD----LEDIKIKINELKDKHDKYEEIKNRYKSLKL 560
PRK12704 PRK12704
phosphodiesterase; Provisional
1005-1135 8.80e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 40.92  E-value: 8.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1005 NRAAKVVQEAHQQtlddlhMEEEKlsslSKANLKLEQQVDELEGALEQERKARmncERELHKLEGNLKlNREsmENLESS 1084
Cdd:PRK12704   38 EEAKRILEEAKKE------AEAIK----KEALLEAKEEIHKLRNEFEKELRER---RNELQKLEKRLL-QKE--ENLDRK 101
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 767926067 1085 QrhlaEELRKKELELSQMNSKVENEKGLVAQLQKTVKELQTQikdLKEKLE 1135
Cdd:PRK12704  102 L----ELLEKREEELEKKEKELEQKQQELEKKEEELEELIEE---QLQELE 145
HEC1 COG5185
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
1212-1571 9.43e-03

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 40.71  E-value: 9.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1212 LAELEGQVENLQQVKQKLEKDKSDLQLEVDDLLTRVEQMTRAKANAEKLCTLYEERLHEATAKLDKVTQLANDLAAQKTK 1291
Cdd:COG5185   189 LKGISELKKAEPSGTVNSIKESETGNLGSESTLLEKAKEIINIEEALKGFQDPESELEDLAQTSDKLEKLVEQNTDLRLE 268
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1292 LWSESGEFLRRLEEkealinqlsrEKSNFTRQIEDLRGQLEKETKSQSALAHALQKaqrdcdllrEQYEEEQEVKAELHR 1371
Cdd:COG5185   269 KLGENAESSKRLNE----------NANNLIKQFENTKEKIAEYTKSIDIKKATESL---------EEQLAAAEAEQELEE 329
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1372 TLSKVNAEMVQWRMKYENNVIQRTEDLEDAKKEL-----AIRLQEAAEAMGVANARNASLERARHQLQLELGDALSD-LG 1445
Cdd:COG5185   330 SKRETETGIQNLTAEIEQGQESLTENLEAIKEEIenivgEVELSKSSEELDSFKDTIESTKESLDEIPQNQRGYAQEiLA 409
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1446 KVRSAAARLDQKQLQSGKALADWKQKHEESQALLDASQKEVQALSTEL--LKLKNTYEESIVGQETLRRENKNLQEEISN 1523
Cdd:COG5185   410 TLEDTLKAADRQIEELQRQIEQATSSNEEVSKLLNELISELNKVMREAdeESQSRLEEAYDEINRSVRSKKEDLNEELTQ 489
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 767926067 1524 LTNQVREGT----KNLTEMEKVKKLIEEEKTEVQVTLEETEGALERNESKIL 1571
Cdd:COG5185   490 IESRVSTLKatleKLRAKLERQLEGVRSKLDQVAESLKDFMRARGYAHILAL 541
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
1658-1929 9.96e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 40.66  E-value: 9.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1658 LQIQIKDLQMQLDDSTQLNSDLKEQVAVAERRNSLLQSELEDLRSLQEQTERGRRLSEEELLEATERINLFYTQNTSLLS 1737
Cdd:COG4372    29 LSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQE 108
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1738 QKKKLEADVARMQKEAEEVVQECQNAEEKAKKAAIEAANLSEELKKKQDTIAHLERTRENMEQTITDLQKRLAEAEQMAL 1817
Cdd:COG4372   109 EAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQELQALSEAEAEQALDEL 188
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926067 1818 MGSRKQIQKLESRVRELEGELEGEIRRSAEAQRGARRLERCIKELTYQAEEDKKNLSRMQTQMDKLQLKVQNYKQQVEVA 1897
Cdd:COG4372   189 LKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKEELLEEVILKEIEELELAIL 268
                         250       260       270
                  ....*....|....*....|....*....|..
gi 767926067 1898 ETQANQYLSKYKKQQHELNEVKERAEVAESQV 1929
Cdd:COG4372   269 VEKDTEEEELEIAALELEALEEAALELKLLAL 300
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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