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Conserved domains on  [gi|767926417|ref|XP_011510998|]
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MORC family CW-type zinc finger protein 1 isoform X8 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Morc6_S5 super family cl39387
Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. ...
 12-213 8.19e-12

Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. Arabidopsis microrchidia (MORC) ATPase family proteins are conserved among plants and animals and are involved in transcriptional silencing. In Arabidopsis, MORC6/DMS11 was reported to function in the condensation of pericentromeric heterochromatin, thereby facilitating transcriptional silencing. Further studies demonstrate that MORC6 and its homologs MORC1 and MORC2 form a complex which associates with SUVH9, required for Pol V occupancy in the RdDM (RNA-directed DNA methylation) pathway.


The actual alignment was detected with superfamily member pfam17942:

Pssm-ID: 465579  Cd Length: 139  Bit Score: 63.33  E-value: 8.19e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926417   12 SFRAYTSVLYFN--PWMRIFIQAKRVKTKHLCYCLYRPRKYLYVTSSFKGAfkdevkkaEEAVKIAESILKEAqikvnqc 89
Cdd:pfam17942   2 SLRAYASILYLRlpPNFQIILRGKKVEHHNIADDLKYPEKITYKPQVGGGK--------EVVVITTIGFLKEA------- 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926417   90 drtslssakdvlqraledveaKQKNLkekqrelktartlslfYGVNVenrsqagmfiYSNNRLIKMHEKVGSQLKLKsll 169
Cdd:pfam17942  67 ---------------------PHINV----------------HGFNV----------YHKNRLIKPFWRVGNQAGSK--- 96

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 767926417  170 GAGVVGIvnipLEV--MEPSHNKQEFLNVQEYNHLLKVMGQYLVQY 213
Cdd:pfam17942  97 GRGVIGV----LEAnfIEPTHDKQDFERTSLYQRLEARLKQMLKEY 138
zf-CW pfam07496
CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four ...
 288-333 1.31e-11

CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by, and is predicted to be a "highly specialized mononuclear four-cysteine zinc finger...that plays a role in DNA binding and/or promoting protein-protein interactions in complicated eukaryotic processes including...chromatin methylation status and early embryonic development." Weak homology to pfam00628 further evidences these predictions (personal obs: C Yeats). Twelve different CW-domain-containing protein subfamilies are described, with different subfamilies being characteriztic of vertebrates, higher plants and other animals in which these domain is found.


:

Pssm-ID: 462181  Cd Length: 46  Bit Score: 60.01  E-value: 1.31e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 767926417  288 FIIQCDLCLKWRVLPSSTNyqEKEFFDIWICANNPNRLENSCHQVE 333
Cdd:pfam07496   1 YWVQCDSCLKWRRLPTEID--PYELPEPWYCSMNPDPKYNSCDAPE 44
 
Name Accession Description Interval E-value
Morc6_S5 pfam17942
Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. ...
 12-213 8.19e-12

Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. Arabidopsis microrchidia (MORC) ATPase family proteins are conserved among plants and animals and are involved in transcriptional silencing. In Arabidopsis, MORC6/DMS11 was reported to function in the condensation of pericentromeric heterochromatin, thereby facilitating transcriptional silencing. Further studies demonstrate that MORC6 and its homologs MORC1 and MORC2 form a complex which associates with SUVH9, required for Pol V occupancy in the RdDM (RNA-directed DNA methylation) pathway.


Pssm-ID: 465579  Cd Length: 139  Bit Score: 63.33  E-value: 8.19e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926417   12 SFRAYTSVLYFN--PWMRIFIQAKRVKTKHLCYCLYRPRKYLYVTSSFKGAfkdevkkaEEAVKIAESILKEAqikvnqc 89
Cdd:pfam17942   2 SLRAYASILYLRlpPNFQIILRGKKVEHHNIADDLKYPEKITYKPQVGGGK--------EVVVITTIGFLKEA------- 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926417   90 drtslssakdvlqraledveaKQKNLkekqrelktartlslfYGVNVenrsqagmfiYSNNRLIKMHEKVGSQLKLKsll 169
Cdd:pfam17942  67 ---------------------PHINV----------------HGFNV----------YHKNRLIKPFWRVGNQAGSK--- 96

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 767926417  170 GAGVVGIvnipLEV--MEPSHNKQEFLNVQEYNHLLKVMGQYLVQY 213
Cdd:pfam17942  97 GRGVIGV----LEAnfIEPTHDKQDFERTSLYQRLEARLKQMLKEY 138
zf-CW pfam07496
CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four ...
 288-333 1.31e-11

CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by, and is predicted to be a "highly specialized mononuclear four-cysteine zinc finger...that plays a role in DNA binding and/or promoting protein-protein interactions in complicated eukaryotic processes including...chromatin methylation status and early embryonic development." Weak homology to pfam00628 further evidences these predictions (personal obs: C Yeats). Twelve different CW-domain-containing protein subfamilies are described, with different subfamilies being characteriztic of vertebrates, higher plants and other animals in which these domain is found.


Pssm-ID: 462181  Cd Length: 46  Bit Score: 60.01  E-value: 1.31e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 767926417  288 FIIQCDLCLKWRVLPSSTNyqEKEFFDIWICANNPNRLENSCHQVE 333
Cdd:pfam07496   1 YWVQCDSCLKWRRLPTEID--PYELPEPWYCSMNPDPKYNSCDAPE 44
KpsE COG3524
Capsule polysaccharide export protein KpsE/RkpR [Cell wall/membrane/envelope biogenesis];
68-127 3.46e-03

Capsule polysaccharide export protein KpsE/RkpR [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442746 [Multi-domain]  Cd Length: 370  Bit Score: 40.60  E-value: 3.46e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767926417  68 AEEAVKIAESILKEAQIKVNQcdrtsLS--SAKDVLQRALEDVEAKQKNLKEKQRELKTART 127
Cdd:COG3524  149 PEDAQAIAEALLAESEELVNQ-----LSerAREDAVRFAEEEVERAEERLRDAREALLAFRN 205
 
Name Accession Description Interval E-value
Morc6_S5 pfam17942
Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. ...
 12-213 8.19e-12

Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. Arabidopsis microrchidia (MORC) ATPase family proteins are conserved among plants and animals and are involved in transcriptional silencing. In Arabidopsis, MORC6/DMS11 was reported to function in the condensation of pericentromeric heterochromatin, thereby facilitating transcriptional silencing. Further studies demonstrate that MORC6 and its homologs MORC1 and MORC2 form a complex which associates with SUVH9, required for Pol V occupancy in the RdDM (RNA-directed DNA methylation) pathway.


Pssm-ID: 465579  Cd Length: 139  Bit Score: 63.33  E-value: 8.19e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926417   12 SFRAYTSVLYFN--PWMRIFIQAKRVKTKHLCYCLYRPRKYLYVTSSFKGAfkdevkkaEEAVKIAESILKEAqikvnqc 89
Cdd:pfam17942   2 SLRAYASILYLRlpPNFQIILRGKKVEHHNIADDLKYPEKITYKPQVGGGK--------EVVVITTIGFLKEA------- 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926417   90 drtslssakdvlqraledveaKQKNLkekqrelktartlslfYGVNVenrsqagmfiYSNNRLIKMHEKVGSQLKLKsll 169
Cdd:pfam17942  67 ---------------------PHINV----------------HGFNV----------YHKNRLIKPFWRVGNQAGSK--- 96

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 767926417  170 GAGVVGIvnipLEV--MEPSHNKQEFLNVQEYNHLLKVMGQYLVQY 213
Cdd:pfam17942  97 GRGVIGV----LEAnfIEPTHDKQDFERTSLYQRLEARLKQMLKEY 138
zf-CW pfam07496
CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four ...
 288-333 1.31e-11

CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by, and is predicted to be a "highly specialized mononuclear four-cysteine zinc finger...that plays a role in DNA binding and/or promoting protein-protein interactions in complicated eukaryotic processes including...chromatin methylation status and early embryonic development." Weak homology to pfam00628 further evidences these predictions (personal obs: C Yeats). Twelve different CW-domain-containing protein subfamilies are described, with different subfamilies being characteriztic of vertebrates, higher plants and other animals in which these domain is found.


Pssm-ID: 462181  Cd Length: 46  Bit Score: 60.01  E-value: 1.31e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 767926417  288 FIIQCDLCLKWRVLPSSTNyqEKEFFDIWICANNPNRLENSCHQVE 333
Cdd:pfam07496   1 YWVQCDSCLKWRRLPTEID--PYELPEPWYCSMNPDPKYNSCDAPE 44
KpsE COG3524
Capsule polysaccharide export protein KpsE/RkpR [Cell wall/membrane/envelope biogenesis];
68-127 3.46e-03

Capsule polysaccharide export protein KpsE/RkpR [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442746 [Multi-domain]  Cd Length: 370  Bit Score: 40.60  E-value: 3.46e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767926417  68 AEEAVKIAESILKEAQIKVNQcdrtsLS--SAKDVLQRALEDVEAKQKNLKEKQRELKTART 127
Cdd:COG3524  149 PEDAQAIAEALLAESEELVNQ-----LSerAREDAVRFAEEEVERAEERLRDAREALLAFRN 205
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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