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Conserved domains on  [gi|767939813|ref|XP_011512822|]
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omega-hydroxyceramide transacylase isoform X2 [Homo sapiens]

Protein Classification

patatin-like phospholipase domain-containing protein( domain architecture ID 27818)

patatin-like phospholipase domain-containing protein may function as a lipid acyl hydrolase, catalyzing the cleavage of fatty acids from membrane lipids

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Patatin_and_cPLA2 super family cl11396
Patatins and Phospholipases; Patatin-like phospholipase. This family consists of various ...
 1-293 0e+00

Patatins and Phospholipases; Patatin-like phospholipase. This family consists of various patatin glycoproteins from plants. The patatin protein accounts for up to 40% of the total soluble protein in potato tubers. Patatin is a storage protein, but it also has the enzymatic activity of a lipid acyl hydrolase, catalyzing the cleavage of fatty acids from membrane lipids. Members of this family have also been found in vertebrates. This family also includes the catalytic domain of cytosolic phospholipase A2 (PLA2; EC 3.1.1.4) hydrolyzes the sn-2-acyl ester bond of phospholipids to release arachidonic acid. At the active site, cPLA2 contains a serine nucleophile through which the catalytic mechanism is initiated. The active site is partially covered by a solvent-accessible flexible lid. cPLA2 displays interfacial activation as it exists in both "closed lid" and "open lid" forms.


The actual alignment was detected with superfamily member cd07219:

Pssm-ID: 416256  Cd Length: 382  Bit Score: 529.08  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939813   1 MVQMMRQFLYRVLPEDSYKVTTGKLHVSLTRLTDGENVVVSEFTSKEELIEALYCSCFVPVYCGLIPPTYRGVRYIDGGF 80
Cdd:cd07219   95 MVQMMRQFLYRVLPEDSYKVATGKLHVSLTRVTDGENVVVSEFTSKEELIEALYCSCFVPVYCGLIPPTYRGVRYIDGGF 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939813  81 TGMQPCAFWTDAITISTFSGQQDICPRDCPAIFHDFRMFNCSFQFSLENIARMTHALFPPDLVILHDYYYRGYEDAVLYL 160
Cdd:cd07219  175 TGMQPCSFWTDSITISTFSGQQDICPRDCPAIFHDFRIFNCSFQFSLENIARMTHALFPPDLMVLHDYYYRGYQDTVLYL 254

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939813 161 RRLNAVYLNSSSKRVIFPRVEVYCQielALGNECPERSQPSLRARQASLEGATQPHKEWVPKGDGRGSHGPPVSQPVQ-- 238
Cdd:cd07219  255 RRLNAVYLNSPSKRVIFPRVEVYCQ---ALGKECPQRSQPSLQDGQASLEESWQPHLARAPKGDGRGLHDPPLSPPLAap 331

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767939813 239 --TLEFTCESPVSAPVSPLEQPPAQplasstPLSLSGMPPVSFPAVHKPPSSTPGSS 293
Cdd:cd07219  332 esTAEWVVESPVSSPASPLESSPSL------PGSLTDLSPASLPAVHSLPSSTPGLS 382
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 195-399 2.74e-05

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.86  E-value: 2.74e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939813  195 PERSQPSLRARQASLEGATQPHKEWVPKGDGRGSHGPPVSQPVQTlefTCESPVSAPVSPLEQP--PAQPLASSTPLSLS 272
Cdd:PHA03247 2623 APDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRA---RRLGRAAQASSPPQRPrrRAARPTVGSLTSLA 2699

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939813  273 GMPPVSFPAVHKPPSSTPGSSLPTPPpglsplspqqQVQPSGSPARSLhsqAPTSPRPSLGPSTVGAPQTLPRSSLSAFP 352
Cdd:PHA03247 2700 DPPPPPPTPEPAPHALVSATPLPPGP----------AAARQASPALPA---APAPPAVPAGPATPGGPARPARPPTTAGP 2766

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 767939813  353 AQ--PPVEELGQEQPQAVALLVSSKPKSAVPLVHVKETVSKPYVTESPA 399
Cdd:PHA03247 2767 PApaPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPA 2815
 
Name Accession Description Interval E-value
Pat_PNPLA1 cd07219
Patatin-like phospholipase domain containing protein 1; Members of this family share a patatin ...
 1-293 0e+00

Patatin-like phospholipase domain containing protein 1; Members of this family share a patatin domain, initially discovered in potato tubers. Some members of PNPLA1 subfamily do not have the lipase consensus sequence Gly-X-Ser-X-Gly which is essential for hydrolase activity. This family includes PNPLA1 from Homo sapiens and Gallus gallus. Currently, there is no literature available on the physiological role, structure, or enzymatic activity of PNPLA1. It is expressed in various human tissues in low mRNA levels.


Pssm-ID: 132858  Cd Length: 382  Bit Score: 529.08  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939813   1 MVQMMRQFLYRVLPEDSYKVTTGKLHVSLTRLTDGENVVVSEFTSKEELIEALYCSCFVPVYCGLIPPTYRGVRYIDGGF 80
Cdd:cd07219   95 MVQMMRQFLYRVLPEDSYKVATGKLHVSLTRVTDGENVVVSEFTSKEELIEALYCSCFVPVYCGLIPPTYRGVRYIDGGF 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939813  81 TGMQPCAFWTDAITISTFSGQQDICPRDCPAIFHDFRMFNCSFQFSLENIARMTHALFPPDLVILHDYYYRGYEDAVLYL 160
Cdd:cd07219  175 TGMQPCSFWTDSITISTFSGQQDICPRDCPAIFHDFRIFNCSFQFSLENIARMTHALFPPDLMVLHDYYYRGYQDTVLYL 254

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939813 161 RRLNAVYLNSSSKRVIFPRVEVYCQielALGNECPERSQPSLRARQASLEGATQPHKEWVPKGDGRGSHGPPVSQPVQ-- 238
Cdd:cd07219  255 RRLNAVYLNSPSKRVIFPRVEVYCQ---ALGKECPQRSQPSLQDGQASLEESWQPHLARAPKGDGRGLHDPPLSPPLAap 331

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767939813 239 --TLEFTCESPVSAPVSPLEQPPAQplasstPLSLSGMPPVSFPAVHKPPSSTPGSS 293
Cdd:cd07219  332 esTAEWVVESPVSSPASPLESSPSL------PGSLTDLSPASLPAVHSLPSSTPGLS 382
PHA03378 PHA03378
EBNA-3B; Provisional
 230-355 2.12e-05

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 47.37  E-value: 2.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939813 230 GPPVSQPVQTLEFTCESPVSAPvSPLEQPPAQPLASSTPLSLSGM--PPVSFPAVHKPPSSTPGSSLPTPPPGLSPLSPQ 307
Cdd:PHA03378 680 GANTMLPIQWAPGTMQPPPRAP-TPMRPPAAPPGRAQRPAAATGRarPPAAAPGRARPPAAAPGRARPPAAAPGRARPPA 758

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767939813 308 QQVQPSGSPARSLHSQAPTSP---------RPSLGPSTVGAPQTLPRSSLSAFPAQP 355
Cdd:PHA03378 759 AAPGRARPPAAAPGAPTPQPPpqappapqqRPRGAPTPQPPPQAGPTSMQLMPRAAP 815
PHA03247 PHA03247
large tegument protein UL36; Provisional
 195-399 2.74e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.86  E-value: 2.74e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939813  195 PERSQPSLRARQASLEGATQPHKEWVPKGDGRGSHGPPVSQPVQTlefTCESPVSAPVSPLEQP--PAQPLASSTPLSLS 272
Cdd:PHA03247 2623 APDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRA---RRLGRAAQASSPPQRPrrRAARPTVGSLTSLA 2699

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939813  273 GMPPVSFPAVHKPPSSTPGSSLPTPPpglsplspqqQVQPSGSPARSLhsqAPTSPRPSLGPSTVGAPQTLPRSSLSAFP 352
Cdd:PHA03247 2700 DPPPPPPTPEPAPHALVSATPLPPGP----------AAARQASPALPA---APAPPAVPAGPATPGGPARPARPPTTAGP 2766

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 767939813  353 AQ--PPVEELGQEQPQAVALLVSSKPKSAVPLVHVKETVSKPYVTESPA 399
Cdd:PHA03247 2767 PApaPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPA 2815
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 200-398 2.89e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 46.68  E-value: 2.89e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939813  200 PSLRARQASLEGATQPHKEwvPKGDGRGSHGPPVSQPVQTLEFTCESPVSAPVSPLEQPPAqPLASSTPLSLSGMPPVSF 279
Cdd:pfam03154 310 PPGPSPAAPGQSQQRIHTP--PSQSQLQSQQPPREQPLPPAPLSMPHIKPPPTTPIPQLPN-PQSHKHPPHLSGPSPFQM 386

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939813  280 PA---------------VHKPPSSTP--------GSSLPTPPPGLSPLSPQQQVQPSGS---PARSLHSQAPTSPRPS-- 331
Cdd:pfam03154 387 NSnlppppalkplsslsTHHPPSAHPpplqlmpqSQQLPPPPAQPPVLTQSQSLPPPAAshpPTSGLHQVPSQSPFPQhp 466

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767939813  332 ---LGPSTVGAPQTLPRSSLSAFPA-QPPveelgQEQPQAVALLVSSKPKSAVPLVHVK-ETVSKPYVTESP 398
Cdd:pfam03154 467 fvpGGPPPITPPSGPPTSTSSAMPGiQPP-----SSASVSSSGPVPAAVSCPLPPVQIKeEALDEAEEPESP 533
RssA COG1752
Predicted acylesterase/phospholipase RssA, containd patatin domain [General function ...
 5-162 4.40e-05

Predicted acylesterase/phospholipase RssA, containd patatin domain [General function prediction only];


Pssm-ID: 441358 [Multi-domain]  Cd Length: 261  Bit Score: 44.89  E-value: 4.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939813   5 MRQFLYRVLPEDSYKVTTGKLHVSLTRLTDGENVVVSEFtskeELIEALYCSCFVPvycGLIPP-TYRGVRYIDGGFTGM 83
Cdd:COG1752   99 LRRLLERLLGDRDFEDLPIPLAVVATDLETGREVVFDSG----PLADAVRASAAIP---GVFPPvEIDGRLYVDGGVVNN 171

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939813  84 QP-------CAfwTDAITISTFSGQQDIcprdcPAIfhdFRMFNCSFQFSLENIARMTHALFPPDLVI--------LHDY 148
Cdd:COG1752  172 LPvdparalGA--DRVIAVDLNPPLRKL-----PSL---LDILGRALEIMFNSILRRELALEPADILIepdlsgisLLDF 241

                        170       180
                 ....*....|....*....|
gi 767939813 149 YYR------GYEDAVLYLRR 162
Cdd:COG1752  242 SRAeelieaGYEAARRALDE 261
Patatin pfam01734
Patatin-like phospholipase; This family consists of various patatin glycoproteins from plants. ...
 5-85 8.91e-05

Patatin-like phospholipase; This family consists of various patatin glycoproteins from plants. The patatin protein accounts for up to 40% of the total soluble protein in potato tubers. Patatin is a storage protein but it also has the enzymatic activity of lipid acyl hydrolase, catalysing the cleavage of fatty acids from membrane lipids. Members of this family have been found also in vertebrates.


Pssm-ID: 396341  Cd Length: 190  Bit Score: 43.37  E-value: 8.91e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939813    5 MRQFLYRVLPEDSYKVTTGKLHVSLTRLTDGENVVVSEFTSKEELIEALYCSCFVPVYcgLIPPTYRGVRYIDGGFTGMQ 84
Cdd:pfam01734 107 LEELAARLSLLLVVALRALLTVISTALGTRARILLPDDLDDDEDLADAVLASSALPGV--FPPVRLDGELYVDGGLVDNV 184


                  .
gi 767939813   85 P 85
Cdd:pfam01734 185 P 185
 
Name Accession Description Interval E-value
Pat_PNPLA1 cd07219
Patatin-like phospholipase domain containing protein 1; Members of this family share a patatin ...
 1-293 0e+00

Patatin-like phospholipase domain containing protein 1; Members of this family share a patatin domain, initially discovered in potato tubers. Some members of PNPLA1 subfamily do not have the lipase consensus sequence Gly-X-Ser-X-Gly which is essential for hydrolase activity. This family includes PNPLA1 from Homo sapiens and Gallus gallus. Currently, there is no literature available on the physiological role, structure, or enzymatic activity of PNPLA1. It is expressed in various human tissues in low mRNA levels.


Pssm-ID: 132858  Cd Length: 382  Bit Score: 529.08  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939813   1 MVQMMRQFLYRVLPEDSYKVTTGKLHVSLTRLTDGENVVVSEFTSKEELIEALYCSCFVPVYCGLIPPTYRGVRYIDGGF 80
Cdd:cd07219   95 MVQMMRQFLYRVLPEDSYKVATGKLHVSLTRVTDGENVVVSEFTSKEELIEALYCSCFVPVYCGLIPPTYRGVRYIDGGF 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939813  81 TGMQPCAFWTDAITISTFSGQQDICPRDCPAIFHDFRMFNCSFQFSLENIARMTHALFPPDLVILHDYYYRGYEDAVLYL 160
Cdd:cd07219  175 TGMQPCSFWTDSITISTFSGQQDICPRDCPAIFHDFRIFNCSFQFSLENIARMTHALFPPDLMVLHDYYYRGYQDTVLYL 254

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939813 161 RRLNAVYLNSSSKRVIFPRVEVYCQielALGNECPERSQPSLRARQASLEGATQPHKEWVPKGDGRGSHGPPVSQPVQ-- 238
Cdd:cd07219  255 RRLNAVYLNSPSKRVIFPRVEVYCQ---ALGKECPQRSQPSLQDGQASLEESWQPHLARAPKGDGRGLHDPPLSPPLAap 331

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767939813 239 --TLEFTCESPVSAPVSPLEQPPAQplasstPLSLSGMPPVSFPAVHKPPSSTPGSS 293
Cdd:cd07219  332 esTAEWVVESPVSSPASPLESSPSL------PGSLTDLSPASLPAVHSLPSSTPGLS 382
Pat_PNPLA_like cd07204
Patatin-like phospholipase domain containing protein family; Members of this family share a ...
 1-162 1.39e-97

Patatin-like phospholipase domain containing protein family; Members of this family share a patain domain, initially discovered in potato tubers. PNPLA protein members show non-specific hydrolase activity with a variety of substrates such as triacylglycerol, phospholipids, and retinylesters. It contains the lipase consensus sequence (Gly-X-Ser-X-Gly). Nomenclature of PNPLA family could be misleading as some of the mammalian members of this family show hydrolase, but no phospholipase activity.


Pssm-ID: 132843 [Multi-domain]  Cd Length: 243  Bit Score: 293.87  E-value: 1.39e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939813   1 MVQMMRQFLYRVLPEDSYKVTTGKLHVSLTRLTDGENVVVSEFTSKEELIEALYCSCFVPVYCGLIPPTYRGVRYIDGGF 80
Cdd:cd07204   82 LLKILRQGLEKILPDDAHELASGRLHISLTRVSDGENVLVSEFDSKEELIQALVCSCFIPFYCGLIPPKFRGVRYIDGGL 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939813  81 TGMQPCAFWTDAITISTFSGQQDICPRDCPAIFHDFRMFNCSFQFSLENIARMTHALFPPDLVILHDYYYRGYEDAVLYL 160
Cdd:cd07204  162 SDNLPILDDENTITVSPFSGESDICPQDKSSNLLEVNIANTSIQLSLENLYRLNRALFPPSLEILSRMCQQGYLDALRFL 241


                 ..
gi 767939813 161 RR 162
Cdd:cd07204  242 ER 243
Pat_PNPLA2 cd07220
Patatin-like phospholipase domain containing protein 2; PNPLA2 plays a key role in hydrolysis ...
 1-162 1.67e-66

Patatin-like phospholipase domain containing protein 2; PNPLA2 plays a key role in hydrolysis of stored triacylglecerols and is also known as adipose triglyceride lipase (ATGL). Members of this family share a patain domain, initially discovered in potato tubers. ATGL is expressed in white and brown adipose tissue in high mRNA levels. Mutations in PNPLA2 encoding adipose triglyceride lipase (ATGL) leads to neutral lipid storage disease (NLSD) which is characterized by the accumulation of triglycerides in multiple tissues. ATGL mutations are also commonly associated with severe forms of skeletal- and cardio-myopathy. This family includes patatin-like proteins: TTS-2.2 (transport-secretion protein 2.2), PNPLA2 (Patatin-like phospholipase domain-containing protein 2), and iPLA2-zeta (Calcium-independent phospholipase A2) from Homo sapiens.


Pssm-ID: 132859  Cd Length: 249  Bit Score: 213.84  E-value: 1.67e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939813   1 MVQMMRQFLYRVLPEDSYKVTTGKLHVSLTRLTDGENVVVSEFTSKEELIEALYCSCFVPVYCGLIPPTYRGVRYIDGGF 80
Cdd:cd07220   87 LVKILRDGLLRTLPENAHELASGRLGISLTRVSDGENVLVSDFNSKEELIQALVCSCFIPVYCGLIPPTLRGVRYVDGGI 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939813  81 TGMQPCAFWTDAITISTFSGQQDICPRDCPAIFHDFRMFNCSFQFSLENIARMTHALFPPDLVILHDYYYRGYEDAVLYL 160
Cdd:cd07220  167 SDNLPQYELKNTITVSPFSGESDICPRDSSTNFHELRFTNTSIQFNLRNLYRLSKALFPPEPQVLAEMCKQGYRDALRFL 246


                 ..
gi 767939813 161 RR 162
Cdd:cd07220  247 KE 248
Pat_iPLA2 cd07218
Calcium-independent phospholipase A2; Classified as Group IVA-1 PLA2; Calcium-independent ...
 5-166 2.01e-60

Calcium-independent phospholipase A2; Classified as Group IVA-1 PLA2; Calcium-independent phospholipase A2; otherwise known as Group IVA-1 PLA2. It contains the lipase consensus sequence (Gly-X-Ser-X-Gly);mutagenesis experiments confirm the role of this serine as a nucleophile. Some members of this group show triacylglycerol lipase activity (EC 3:1:1:3). Members include iPLA-1, iPLA-2, and iPLA-3 from Aedes aegypti and show acylglycerol transacylase/lipase activity. Also includes putative iPLA2-eta from Pediculus humanus corporis which shows patatin-like phospholipase activity.


Pssm-ID: 132857  Cd Length: 245  Bit Score: 197.95  E-value: 2.01e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939813   5 MRQFLYRVLPEDSYKVTTGKLHVSLTRLTDGENVVVSEFTSKEELIEALYCSCFVPVYCGLIPPTYRGVRYIDGGFTGMQ 84
Cdd:cd07218   85 LLEGLQKFLPDDAHERVSGRLHISLTRVSDGKNVIVSEFESREELLQALLCSCFIPVFSGLLPPKFRGVRYMDGGFSDNL 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939813  85 PcAFWTDAITISTFSGQQDICPRDCPAIFHDFRMFNCSFQFSLENIARMTHALFPPDLVILHDYYYRGYEDAVLYLRRLN 164
Cdd:cd07218  165 P-TLDENTITVSPFCGESDICPRDNSSQLFHINWANTSIELSRQNIYRLVRILFPPRPEVLSSLCQQGFDDALRFLHRNN 243


                 ..
gi 767939813 165 AV 166
Cdd:cd07218  244 LI 245
Pat_PNPLA3 cd07221
Patatin-like phospholipase domain containing protein 3; PNPLA3 is a triacylglycerol lipase ...
 1-160 2.35e-50

Patatin-like phospholipase domain containing protein 3; PNPLA3 is a triacylglycerol lipase that mediates triacylglycerol hydrolysis in adipocytes and is an indicator of the nutritional state. PNPLA3 is also known as adiponutrin (ADPN) or iPLA2-epsilon. Human adiponutrins are bound to the cell membrane of adipocytes and show transacylase, TG hydrolase, and PLA2 activity. This family includes patatin-like proteins: ADPN (adiponutrin) from mammals, PNPLA3 (Patatin-like phospholipase domain-containing protein 3), and iPLA2-epsilon (Calcium-independent phospholipase A2) from Homo sapiens.


Pssm-ID: 132860  Cd Length: 252  Bit Score: 171.88  E-value: 2.35e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939813   1 MVQMMRQFLYRVLPEDSYKVTTGKLHVSLTRLTDGENVVVSEFTSKEELIEALYCSCFVPVYCGLIPPTYRGVRYIDGGF 80
Cdd:cd07221   83 LSKHLRDGLQRHLPDNVHQLISGKMCISLTRVSDGENVLVSDFHSKDEVVDALVCSCFIPFFSGLIPPSFRGVRYVDGGV 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939813  81 TGMQPCAFWTDAITISTFSGQQDICPRDCPAIFHDFRMFNCSFQFSLENIARMTHALFPPDLVILHDYYYRGYEDAVLYL 160
Cdd:cd07221  163 SDNVPFFDAKTTITVSPFYGEYDICPKVKSTNFLHVDFTKLSLRLCTENLYLLTRALFPPDVKVLGEICLRGYLDAFRFL 242
Pat_PNPLA4 cd07222
Patatin-like phospholipase domain containing protein 4; PNPLA4, also known as GS2 (gene ...
 5-164 4.54e-50

Patatin-like phospholipase domain containing protein 4; PNPLA4, also known as GS2 (gene sequence-2), shows both lipase and transacylation activities. GS2 lipase is expressed in various tissues, predominantly in muscle and adipocytes tissue. It is also expressed in keratinocytes and shows retinyl ester hydrolase, acylglycerol, TG hydrolase, and PLA2 activity. This family includes patatin-like proteins: GS2 from mammals, PNPLA4 (Patatin-like phospholipase domain-containing protein 4), and iPLA2-eta (Calcium-independent phospholipase A2) from Homo sapiens.


Pssm-ID: 132861 [Multi-domain]  Cd Length: 246  Bit Score: 170.97  E-value: 4.54e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939813   5 MRQFLYRVLPEDSYKVTTGKLHVSLTRLTDGENVVVSEFTSKEELIEALYCSCFVPVYCGLIPPTYRGVRYIDGGFTGMQ 84
Cdd:cd07222   87 LRKGIESILPTDAHELANDRLHVSITNLKTRKNYLVSNFTSREDLIKVLLASCYVPVYAGLKPVEYKGQKWIDGGFTNSL 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939813  85 PCAFWTDAITISTFSGQQDICPRDCPAIFHDFRMFNCSFQFSLENIARMTHALFPPDLVILHDYYYRGYEDAVLYLRRLN 164
Cdd:cd07222  167 PVLPVGRTITVSPFSGRADICPQDKGQLDLYVRFANQDIMLSLANLVRLNQALFPPNRRKLESYYQMGFDDAVRFLKKEN 246
Pat_PNPLA5-mammals cd07223
Patatin-like phospholipase domain containing protein 5; PNPLA5, also known as GS2L (GS2-like), ...
 2-162 4.24e-39

Patatin-like phospholipase domain containing protein 5; PNPLA5, also known as GS2L (GS2-like), plays a role in regulation of adipocyte differentiation. PNPLA5 is expressed in brain tissue in high mRNA levels and low levels in liver tissue. There is no concrete evidence in support of the enzymatic activity of GS2L. This family includes patatin-like proteins: GS2L (GS2-like) and PNPLA5 (Patatin-like phospholipase domain-containing protein 5) reported exclusively in mammals.


Pssm-ID: 132862  Cd Length: 405  Bit Score: 146.21  E-value: 4.24e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939813   2 VQMMRQFLYRVLPEDSYKVTTGKLHVSLTRLTDGENVVVSEFTSKEELIEALYCSCFVPVYCGLIPPTYRGVRYIDGGFT 81
Cdd:cd07223   93 IEHIRQQLQESLPPNIHILASQRLGISMTRWPDGRNFIVTDFATRDELIQALICTLYFPFYCGIIPPEFRGERYIDGALS 172

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939813  82 GMQPCAFWTDAITISTFSGQQDICPRDCPAIFHDFRMFNCSFQFSLENIARMTHALFPPDLVILHDYYYRGYEDAVLYLR 161
Cdd:cd07223  173 NNLPFSDCPSTITVSPFHGTVDICPQSTSANLHELNAFNASFQISTRNFFLGLKCLIPPKPEVVADNCRQGYLDALRFLE 252


                 .
gi 767939813 162 R 162
Cdd:cd07223  253 R 253
Patatin cd07198
Patatin-like phospholipase; Patatin is a storage protein of the potato tuber that shows ...
 1-96 4.09e-33

Patatin-like phospholipase; Patatin is a storage protein of the potato tuber that shows Phospholipase A2 activity (PLA2; EC 3.1.1.4). Patatin catalyzes the nonspecific hydrolysis of phospholipids, glycolipids, sulfolipids, and mono- and diacylglycerols, thereby showing lipid acyl hydrolase activity. The active site includes an oxyanion hole with a conserved GGxR motif; it is found in almost all the members of this family. The catalytic dyad is formed by a serine and an aspartate. Patatin belongs to the alpha-beta hydrolase family which is identified by a characteristic nucleophile elbow with a consensus sequence of Sm-X-Nu-Sm (Sm = small residue, X = any residue and Nu = nucleophile). Members of this family have been found also in vertebrates. This family includes PNPLA (1-9), TGL (3-5), ExoU-like, and SDP1-like subfamilies. There are some additional hypothetical proteins included in this family.


Pssm-ID: 132837 [Multi-domain]  Cd Length: 172  Bit Score: 123.22  E-value: 4.09e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939813   1 MVQMMRQFLYRVLPEDSYKVTTGKLHVSLTRLTDGENVVVSeFTSKEELIEALYCSCFVPVYCGLIPPTYRGVRYIDGGF 80
Cdd:cd07198   77 LLGILRQPLLSALPDDAHEDASGKLFISLTRLTDGENVLVS-DTSKGELWSAVRASSSIPGYFGPVPLSFRGRRYGDGGL 155

                         90
                 ....*....|....*.
gi 767939813  81 TGMQPCAFWTDAITIS 96
Cdd:cd07198  156 SNNLPVAELGNTINVS 171
Patatin_and_cPLA2 cd01819
Patatins and Phospholipases; Patatin-like phospholipase. This family consists of various ...
 1-97 3.00e-22

Patatins and Phospholipases; Patatin-like phospholipase. This family consists of various patatin glycoproteins from plants. The patatin protein accounts for up to 40% of the total soluble protein in potato tubers. Patatin is a storage protein, but it also has the enzymatic activity of a lipid acyl hydrolase, catalyzing the cleavage of fatty acids from membrane lipids. Members of this family have also been found in vertebrates. This family also includes the catalytic domain of cytosolic phospholipase A2 (PLA2; EC 3.1.1.4) hydrolyzes the sn-2-acyl ester bond of phospholipids to release arachidonic acid. At the active site, cPLA2 contains a serine nucleophile through which the catalytic mechanism is initiated. The active site is partially covered by a solvent-accessible flexible lid. cPLA2 displays interfacial activation as it exists in both "closed lid" and "open lid" forms.


Pssm-ID: 132836 [Multi-domain]  Cd Length: 155  Bit Score: 92.86  E-value: 3.00e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939813   1 MVQMMRQFLYrvlpedsyKVTTGKLHVSLTRLTDGENVVVSEFTSKEELIEALYCSCFVPVYCGLIPP----------TY 70
Cdd:cd01819   52 LDNKPRQSLE--------EALSGKLWVSFTPVTAGENVLVSRFVSKEELIRALFASGSWPSYFGLIPPaelytsksnlKE 123

                         90       100       110
                 ....*....|....*....|....*....|..
gi 767939813  71 RGVRYIDGGFTGMQPCA-----FWTDAITIST 97
Cdd:cd01819  124 KGVRLVDGGVSNNLPAPvllrpGRGVTLTISP 155
Pat_like cd07224
Patatin-like phospholipase; Patatin-like phospholipase. This family consists of various ...
 4-162 2.37e-19

Patatin-like phospholipase; Patatin-like phospholipase. This family consists of various patatin glycoproteins from plants. The patatin protein accounts for up to 40% of the total soluble protein in potato tubers. Patatin is a storage protein, but it also has the enzymatic activity of lipid acyl hydrolase, catalysing the cleavage of fatty acids from membrane lipids. Members of this family have been found also in vertebrates.


Pssm-ID: 132863  Cd Length: 233  Bit Score: 87.01  E-value: 2.37e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939813   4 MMRQFLYRVLPEDSY-KVTTGKLHVSLTRL---TDGENVvvSEFTSKEELIEALYCSCFVPVYCGLIPPT-YRGVRYIDG 78
Cdd:cd07224   78 VLRDELDKTLPDDAHeRCNRGRIRVAVTQLfpvPRGLLV--SSFDSKSDLIDALLASCNIPGYLAPWPATmFRGKLCVDG 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939813  79 GFTGMQP-----------CAFWTDAITISTfsgqQDICPRDCPAifHDFRMFNCSFQfsleniarmthALFPPDLVILHD 147
Cdd:cd07224  156 GFALFIPpttaadrtvrvCPFPASRSSIKG----QNLDNDDTED--VPYSRRQLLNW-----------ALEPADDAMLLE 218

                        170
                 ....*....|....*
gi 767939813 148 YYYRGYEDAVLYLRR 162
Cdd:cd07224  219 LFNEGYKDANEWAKE 233
PHA03378 PHA03378
EBNA-3B; Provisional
 230-355 2.12e-05

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 47.37  E-value: 2.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939813 230 GPPVSQPVQTLEFTCESPVSAPvSPLEQPPAQPLASSTPLSLSGM--PPVSFPAVHKPPSSTPGSSLPTPPPGLSPLSPQ 307
Cdd:PHA03378 680 GANTMLPIQWAPGTMQPPPRAP-TPMRPPAAPPGRAQRPAAATGRarPPAAAPGRARPPAAAPGRARPPAAAPGRARPPA 758

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767939813 308 QQVQPSGSPARSLHSQAPTSP---------RPSLGPSTVGAPQTLPRSSLSAFPAQP 355
Cdd:PHA03378 759 AAPGRARPPAAAPGAPTPQPPpqappapqqRPRGAPTPQPPPQAGPTSMQLMPRAAP 815
PHA03247 PHA03247
large tegument protein UL36; Provisional
 195-369 2.50e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 47.24  E-value: 2.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939813  195 PERSQPSLRARQASLEGATQPhkeWVPKGDGRGSHGPPVSQPVQTLEFTCESPVSAPVSPLEQPPAQPLASSTPLSLSGM 274
Cdd:PHA03247 2781 RRLTRPAVASLSESRESLPSP---WDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVA 2857

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939813  275 P-------PVSFPAVHKP--PSSTPGSSLPtppPGLSPLSPQQQVQPSGSPARSLHSQAPTSPRPSLGPSTVGAPQTLPR 345
Cdd:PHA03247 2858 PggdvrrrPPSRSPAAKPaaPARPPVRRLA---RPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPP 2934

                         170       180
                  ....*....|....*....|....*
gi 767939813  346 S-SLSAFPAQPPVEELGQEQPQAVA 369
Cdd:PHA03247 2935 PpPRPQPPLAPTTDPAGAGEPSGAV 2959
PHA03247 PHA03247
large tegument protein UL36; Provisional
 195-399 2.74e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.86  E-value: 2.74e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939813  195 PERSQPSLRARQASLEGATQPHKEWVPKGDGRGSHGPPVSQPVQTlefTCESPVSAPVSPLEQP--PAQPLASSTPLSLS 272
Cdd:PHA03247 2623 APDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRA---RRLGRAAQASSPPQRPrrRAARPTVGSLTSLA 2699

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939813  273 GMPPVSFPAVHKPPSSTPGSSLPTPPpglsplspqqQVQPSGSPARSLhsqAPTSPRPSLGPSTVGAPQTLPRSSLSAFP 352
Cdd:PHA03247 2700 DPPPPPPTPEPAPHALVSATPLPPGP----------AAARQASPALPA---APAPPAVPAGPATPGGPARPARPPTTAGP 2766

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 767939813  353 AQ--PPVEELGQEQPQAVALLVSSKPKSAVPLVHVKETVSKPYVTESPA 399
Cdd:PHA03247 2767 PApaPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPA 2815
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 200-398 2.89e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 46.68  E-value: 2.89e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939813  200 PSLRARQASLEGATQPHKEwvPKGDGRGSHGPPVSQPVQTLEFTCESPVSAPVSPLEQPPAqPLASSTPLSLSGMPPVSF 279
Cdd:pfam03154 310 PPGPSPAAPGQSQQRIHTP--PSQSQLQSQQPPREQPLPPAPLSMPHIKPPPTTPIPQLPN-PQSHKHPPHLSGPSPFQM 386

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939813  280 PA---------------VHKPPSSTP--------GSSLPTPPPGLSPLSPQQQVQPSGS---PARSLHSQAPTSPRPS-- 331
Cdd:pfam03154 387 NSnlppppalkplsslsTHHPPSAHPpplqlmpqSQQLPPPPAQPPVLTQSQSLPPPAAshpPTSGLHQVPSQSPFPQhp 466

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767939813  332 ---LGPSTVGAPQTLPRSSLSAFPA-QPPveelgQEQPQAVALLVSSKPKSAVPLVHVK-ETVSKPYVTESP 398
Cdd:pfam03154 467 fvpGGPPPITPPSGPPTSTSSAMPGiQPP-----SSASVSSSGPVPAAVSCPLPPVQIKeEALDEAEEPESP 533
RssA COG1752
Predicted acylesterase/phospholipase RssA, containd patatin domain [General function ...
 5-162 4.40e-05

Predicted acylesterase/phospholipase RssA, containd patatin domain [General function prediction only];


Pssm-ID: 441358 [Multi-domain]  Cd Length: 261  Bit Score: 44.89  E-value: 4.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939813   5 MRQFLYRVLPEDSYKVTTGKLHVSLTRLTDGENVVVSEFtskeELIEALYCSCFVPvycGLIPP-TYRGVRYIDGGFTGM 83
Cdd:COG1752   99 LRRLLERLLGDRDFEDLPIPLAVVATDLETGREVVFDSG----PLADAVRASAAIP---GVFPPvEIDGRLYVDGGVVNN 171

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939813  84 QP-------CAfwTDAITISTFSGQQDIcprdcPAIfhdFRMFNCSFQFSLENIARMTHALFPPDLVI--------LHDY 148
Cdd:COG1752  172 LPvdparalGA--DRVIAVDLNPPLRKL-----PSL---LDILGRALEIMFNSILRRELALEPADILIepdlsgisLLDF 241

                        170       180
                 ....*....|....*....|
gi 767939813 149 YYR------GYEDAVLYLRR 162
Cdd:COG1752  242 SRAeelieaGYEAARRALDE 261
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 210-383 5.54e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 45.75  E-value: 5.54e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939813 210 EGATQPHKEWVPKGDGRGSHGPPVSQPVQTLEFTCESPVSAPVSPLEQPPAQPLASSTPlslsgmPPVSFPAVHKPPSST 289
Cdd:PRK07764 371 ERGLLARLERLERRLGVAGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAP------QPAPAPAPAPAPPSP 444

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939813 290 PGSSlptppPGLSPLSPQQQVQPSGSPARSLHSQAPTSPRPSLGPSTVGAPQTLPRSSLSAFPAQPP--VEELGQEQPQA 367
Cdd:PRK07764 445 AGNA-----PAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAGAddAATLRERWPEI 519

                        170
                 ....*....|....*.
gi 767939813 368 VALLVSSKPKSAVPLV 383
Cdd:PRK07764 520 LAAVPKRSRKTWAILL 535
PHA03247 PHA03247
large tegument protein UL36; Provisional
 195-399 6.14e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.70  E-value: 6.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939813  195 PERSQPSLRARQASLEGATQPHKEWVPKGDGRGSHGPPVSQPvqtleftceSPVSAPvsPLEQPPAQPLASSTPLSLSGM 274
Cdd:PHA03247 2575 PRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSP---------LPPDTH--APDPPPPSPSPAANEPDPHPP 2643

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939813  275 PPVSFPAVHKPPSSTPGSSLPtpppglsplspqQQVQPSGSPARSlhSQAPTSPRPSLGPSTVGA-------------PQ 341
Cdd:PHA03247 2644 PTVPPPERPRDDPAPGRVSRP------------RRARRLGRAAQA--SSPPQRPRRRAARPTVGSltsladpppppptPE 2709

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 767939813  342 TLPRSSLSAFPAQPPVEELGQEQPQAVALLVSSKPKSAVPLVHVKETVSKPYVTESPA 399
Cdd:PHA03247 2710 PAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPP 2767
Patatin pfam01734
Patatin-like phospholipase; This family consists of various patatin glycoproteins from plants. ...
 5-85 8.91e-05

Patatin-like phospholipase; This family consists of various patatin glycoproteins from plants. The patatin protein accounts for up to 40% of the total soluble protein in potato tubers. Patatin is a storage protein but it also has the enzymatic activity of lipid acyl hydrolase, catalysing the cleavage of fatty acids from membrane lipids. Members of this family have been found also in vertebrates.


Pssm-ID: 396341  Cd Length: 190  Bit Score: 43.37  E-value: 8.91e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939813    5 MRQFLYRVLPEDSYKVTTGKLHVSLTRLTDGENVVVSEFTSKEELIEALYCSCFVPVYcgLIPPTYRGVRYIDGGFTGMQ 84
Cdd:pfam01734 107 LEELAARLSLLLVVALRALLTVISTALGTRARILLPDDLDDDEDLADAVLASSALPGV--FPPVRLDGELYVDGGLVDNV 184


                  .
gi 767939813   85 P 85
Cdd:pfam01734 185 P 185
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
227-366 1.15e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 44.77  E-value: 1.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939813 227 GSHGPPVSQPVQTLEFTCESPVSAPvspleQPPAQPLASSTPLSLSGMPPVSFPavhkPPSSTPGSSLPTPPPGLSPlsp 306
Cdd:PRK14971 366 GDDASGGRGPKQHIKPVFTQPAAAP-----QPSAAAAASPSPSQSSAAAQPSAP----QSATQPAGTPPTVSVDPPA--- 433

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939813 307 QQQVQPSGSPARSLHSQ-------APTSPRPSLGPSTVGA---PQTLPRSSLSAFPAQPPVEELGQEQPQ 366
Cdd:PRK14971 434 AVPVNPPSTAPQAVRPAqfkeekkIPVSKVSSLGPSTLRPiqeKAEQATGNIKEAPTGTQKEIFTEEDLQ 503
PHA03247 PHA03247
large tegument protein UL36; Provisional
 230-366 2.07e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.16  E-value: 2.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939813  230 GPPVSQPVQtleftceSPVSAPVSPLEQPPAQPLASSTPlslsGMPPVSFPAVHKPPSSTPGSSLPTPPPGLSPLSPQQQ 309
Cdd:PHA03247 2765 GPPAPAPPA-------APAAGPPRRLTRPAVASLSESRE----SLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTS 2833

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 767939813  310 VQPSGSPARSLHSQAPTSPRPSLGPSTVGAPQTLPRSSLS--AFPAQPPVEELGQEQPQ 366
Cdd:PHA03247 2834 AQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAkpAAPARPPVRRLARPAVS 2892
PLN02217 PLN02217
probable pectinesterase/pectinesterase inhibitor
 259-390 3.20e-04

probable pectinesterase/pectinesterase inhibitor


Pssm-ID: 215130 [Multi-domain]  Cd Length: 670  Bit Score: 43.15  E-value: 3.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939813 259 PAQPLASSTPLSLSGMP--PVSFPAVHKPPSSTPGSSLPTPPPGLSPLSPQQQVQPSGSPARSLHSQAPTSPRPSLGPST 336
Cdd:PLN02217 540 PAQYIQGDAWIPGKGVPyiPGLFAGNPGSTNSTPTGSAASSNTTFSSDSPSTVVAPSTSPPAGHLGSPPATPSKIVSPST 619

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767939813 337 vgAPqtlPRSSLSAfpaqPPVEELGQEQPQAVALLVSSKPKSAVPLVHVKETVS 390
Cdd:PLN02217 620 --SP---PASHLGS----PSTTPSSPESSIKVASTETASPESSIKVASTESSVS 664
PHA03247 PHA03247
large tegument protein UL36; Provisional
 195-376 3.43e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.39  E-value: 3.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939813  195 PERSQPSLRAR-QASLEGATQPHKEWVPKGdgrgshGPPVSQPVQTL------EFTCESPVSAPVSPLEQP--------- 258
Cdd:PHA03247 2658 PGRVSRPRRARrLGRAAQASSPPQRPRRRA------ARPTVGSLTSLadppppPPTPEPAPHALVSATPLPpgpaaarqa 2731

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939813  259 -PAQPLASSTPLSLSGMPPVSFPAVHKPPSSTPGSSLPTPPPGLSPLSPQQQVQPSGSPARSLHSQAPTSPRPSLGPSTV 337
Cdd:PHA03247 2732 sPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAV 2811

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 767939813  338 GAPQ-TLPRSSLSAFPAQPPVEELGQEQPQAVALLVSSKP 376
Cdd:PHA03247 2812 LAPAaALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLP 2851
PHA03247 PHA03247
large tegument protein UL36; Provisional
 200-381 7.21e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.23  E-value: 7.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939813  200 PSLRARQASLEGATQPHKEWVPKGdgrgshGPPVSQPVQTLEFTCESPVSAPVSPLEQPPAQPL--------ASSTPLSL 271
Cdd:PHA03247 2754 PARPARPPTTAGPPAPAPPAAPAA------GPPRRLTRPAVASLSESRESLPSPWDPADPPAAVlapaaalpPAASPAGP 2827

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939813  272 SGMPPVSFPAVHKPPSSTP-------GSSLPTPPPGLSPLSPqqqvQPSGSPARSLHSQAPTSPRPSLGPSTvgAPQTLP 344
Cdd:PHA03247 2828 LPPPTSAQPTAPPPPPGPPppslplgGSVAPGGDVRRRPPSR----SPAAKPAAPARPPVRRLARPAVSRST--ESFALP 2901

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 767939813  345 RSSLSAFPA-QPPVEELGQEQPQAVALLVSSKPKSAVP 381
Cdd:PHA03247 2902 PDQPERPPQpQAPPPPQPQPQPPPPPQPQPPPPPPPRP 2939
PHA03247 PHA03247
large tegument protein UL36; Provisional
 195-402 9.56e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.85  E-value: 9.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939813  195 PERSQPSLrarqaSLEGATQPHKEWVPKGDGRGSHGPPVSQPVQTLEFTCESPVSAPVSPLEQPPAQPLASSTPLSlsgm 274
Cdd:PHA03247 2843 PGPPPPSL-----PLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQA---- 2913

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939813  275 PPVSFPAVHKPPSSTPGSSLPTPPPGLSPLSPQQQVQPSGSParslhsqAPTSPRPSLG---PSTVGAPQTL---PRSSL 348
Cdd:PHA03247 2914 PPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEP-------SGAVPQPWLGalvPGRVAVPRFRvpqPAPSR 2986

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939813  349 SAfPAQPPVEELGQEQPQ------AVALLVSSKPksavPLVHVKETVSKPYVTESPAEDS 402
Cdd:PHA03247 2987 EA-PASSTPPLTGHSLSRvsswasSLALHEETDP----PPVSLKQTLWPPDDTEDSDADS 3041
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 246-401 1.11e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 41.39  E-value: 1.11e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939813 246 SPVSAPVSPLEQPPAQPLASSTPLSLSGMPPVSFPAVHKPPSSTPgsslptpppglsplspQQQVQPSGSPARSLHSQAP 325
Cdd:PRK07994 363 APLPEPEVPPQSAAPAASAQATAAPTAAVAPPQAPAVPPPPASAP----------------QQAPAVPLPETTSQLLAAR 426

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939813 326 TSPRPSLGPSTVGAPQtlPRSSLSAFPAQPPVEELGQEQPQAVALLVSSKPKSAV------PLVHVKETVSKPYVTESPA 399
Cdd:PRK07994 427 QQLQRAQGATKAKKSE--PAAASRARPVNSALERLASVRPAPSALEKAPAKKEAYrwkatnPVEVKKEPVATPKALKKAL 504


                 ..
gi 767939813 400 ED 401
Cdd:PRK07994 505 EH 506
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 197-343 1.22e-03

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 41.56  E-value: 1.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939813  197 RSQPSLRARQASLEGATQPHKEWVPKGDGRGSHGPPVSQPVQTLEFTCESP----VSAPVSPLEQPPAQPLASSTPlsls 272
Cdd:pfam09770 204 RAQAKKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQqhpgQGHPVTILQRPQSPQPDPAQP---- 279

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767939813  273 GMPPVSFPAVHKPPsstPGSSLPT--------PPPGLSPLSPQQQVQPSGSPARSLHSQAPTSPRPslgPSTVGAPQTL 343
Cdd:pfam09770 280 SIQPQAQQFHQQPP---PVPVQPTqilqnpnrLSAARVGYPQNPQPGVQPAPAHQAHRQQGSFGRQ---APIITHPQQL 352
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 195-369 7.64e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 38.81  E-value: 7.64e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939813 195 PERSQPSLRARQASLEGATQPHKEWVPKGDGRGSHGPPVSQPVQTleftcESPVSAPVSPLEQPPAQPlasstplslSGM 274
Cdd:PRK07764 624 PAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDG-----WPAKAGGAAPAAPPPAPA---------PAA 689

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939813 275 PPVSFPAVHKPPSSTPGSSLPTPPPGLSPLSPQQQVQPSGSPARSLHSQAPTSPRPSLGPSTVGAPQTLPrsslsafPAQ 354
Cdd:PRK07764 690 PAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQPP-------PPP 762

                        170
                 ....*....|....*
gi 767939813 355 PPVEELGQEQPQAVA 369
Cdd:PRK07764 763 APAPAAAPAAAPPPS 777
PHA03378 PHA03378
EBNA-3B; Provisional
 257-366 7.72e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 38.89  E-value: 7.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939813 257 QPPAQPLASSTPLSLSGMPPVSFPAVHKPPSSTPGSSLPTPPPGLSPLSPQQQVQPSGSPARSLHSQAPTSPRPSLGPST 336
Cdd:PHA03378 668 QIGHIPYQPSPTGANTMLPIQWAPGTMQPPPRAPTPMRPPAAPPGRAQRPAAATGRARPPAAAPGRARPPAAAPGRARPP 747

                         90       100       110
                 ....*....|....*....|....*....|
gi 767939813 337 VGAPQTLPRSSLSAFPAQPPVEELGQEQPQ 366
Cdd:PHA03378 748 AAAPGRARPPAAAPGRARPPAAAPGAPTPQ 777
Pat_hypo_Ecoli_Z1214_like cd07209
Hypothetical patatin similar to Z1214 protein of Escherichia coli; Patatin-like phospholipase ...
 4-81 8.43e-03

Hypothetical patatin similar to Z1214 protein of Escherichia coli; Patatin-like phospholipase similar to Z1214 protein of Escherichia coli. This family predominantly consists of bacterial patatin glycoproteins and some representatives from eukaryotes and archaea. The patatin protein accounts for up to 40% of the total soluble protein in potato tubers. Patatin is a storage protein, but it also has the enzymatic activity of a lipid acyl hydrolase, catalyzing the cleavage of fatty acids from membrane lipids. Members of this family have also been found in vertebrates.


Pssm-ID: 132848 [Multi-domain]  Cd Length: 215  Bit Score: 37.66  E-value: 8.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939813   4 MMRQFLYRVLPEDS---YKVTTGKLHVSLTRLTDGENVVVSEfTSKEELIEALYCSCFVPVycGLIPPTYRGVRYIDGGF 80
Cdd:cd07209   67 FLRGLLDRALDFDTlrlLAILFAGLVIVAVNVLTGEPVYFDD-IPDGILPEHLLASAALPP--FFPPVEIDGRYYWDGGV 143


                 .
gi 767939813  81 T 81
Cdd:cd07209  144 V 144
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
246-400 9.78e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 38.32  E-value: 9.78e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939813 246 SPVSAPVSPlEQPPAQPLASSTPLSLSGMPPVSFPAVHKPPSSTPGSSLPTPPPGLSPLSPQQQVQPSGSPARSLHSQAP 325
Cdd:PRK12323 376 TAAAAPVAQ-PAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPAPAP 454

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767939813 326 TS--------PRPSLGPSTVGAPQTLPRSSLSAFPA-----QPPVEELGQEQPQAvallvSSKPKSAVPLVHVKETVSKP 392
Cdd:PRK12323 455 AAapaaaarpAAAGPRPVAAAAAAAPARAAPAAAPApadddPPPWEELPPEFASP-----APAQPDAAPAGWVAESIPDP 529


                 ....*...
gi 767939813 393 YVTESPAE 400
Cdd:PRK12323 530 ATADPDDA 537
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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