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Conserved domains on  [gi|767952746|ref|XP_011515240|]
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DENN domain-containing protein 3 isoform X17 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 91-153 8.33e-14

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


:

Pssm-ID: 129037  Cd Length: 69  Bit Score: 66.93  E-value: 8.33e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767952746    91 NCQIQQTTLQLLVSIFRDVKNHLNY------EHRVFNSEEFLKTRAPGDHQFYKQVLDTYMFHSFLKAR 153
Cdd:smart00801   1 NDEIREAFLRFFVNLFGGYRNFLRElrkepgPVITFDKESFLKSRPSSERPFLSKFLETQMFSQFIEER 69
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 675-776 5.49e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 52.34  E-value: 5.49e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767952746 675 HSFKVGTAKVNCMVMADQNQ-VWVGSEDSVIYIINVHSMSCNKQLTAHCSSVTDLI-VQDGQEapsnVYSCSMDGMVLVW 752
Cdd:cd00200    3 RTLKGHTGGVTCVAFSPDGKlLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAaSADGTY----LASGSSDKTIRLW 78

                         90       100
                 ....*....|....*....|....
gi 767952746 753 NVSTLQVTSRFQLPRGGLTSIRLH 776
Cdd:cd00200   79 DLETGECVRTLTGHTSYVSSVAFS 102
 
Name Accession Description Interval E-value
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 91-153 8.33e-14

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 129037  Cd Length: 69  Bit Score: 66.93  E-value: 8.33e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767952746    91 NCQIQQTTLQLLVSIFRDVKNHLNY------EHRVFNSEEFLKTRAPGDHQFYKQVLDTYMFHSFLKAR 153
Cdd:smart00801   1 NDEIREAFLRFFVNLFGGYRNFLRElrkepgPVITFDKESFLKSRPSSERPFLSKFLETQMFSQFIEER 69
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 675-776 5.49e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 52.34  E-value: 5.49e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767952746 675 HSFKVGTAKVNCMVMADQNQ-VWVGSEDSVIYIINVHSMSCNKQLTAHCSSVTDLI-VQDGQEapsnVYSCSMDGMVLVW 752
Cdd:cd00200    3 RTLKGHTGGVTCVAFSPDGKlLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAaSADGTY----LASGSSDKTIRLW 78

                         90       100
                 ....*....|....*....|....
gi 767952746 753 NVSTLQVTSRFQLPRGGLTSIRLH 776
Cdd:cd00200   79 DLETGECVRTLTGHTSYVSSVAFS 102
WD40 COG2319
WD40 repeat [General function prediction only];
660-773 6.36e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 49.52  E-value: 6.36e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767952746 660 GKVTVFNASSWTIhQHSFKVGTAKVNCMVMA-DQNQVWVGSEDSVIYIINVHSMSCNKQLTAHCSSVTDL-IVQDGQEap 737
Cdd:COG2319  268 GTVRLWDLATGEL-LRTLTGHSGGVNSVAFSpDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVaFSPDGKT-- 344

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 767952746 738 snVYSCSMDGMVLVWNVSTLQVTSRFQLPRGGLTSI 773
Cdd:COG2319  345 --LASGSDDGTVRLWDLATGELLRTLTGHTGAVTSV 378
dDENN pfam03455
dDENN domain; This region is always found associated with pfam02141. It is predicted to form a ...
 120-157 1.41e-04

dDENN domain; This region is always found associated with pfam02141. It is predicted to form a globular domain. Although not statistically supported it has been suggested that this domain may be similar to members of the Rho/Rac/Cdc42 GEF family. This N-terminal region of DENN folds into a longin module, consisting of a central antiparallel beta-sheet layered between helix H1 and helices H2 and H3 (strands S1-S5). Rab35 interacts with dDENN via residues in helix 1 and in the loop S3-S4.


Pssm-ID: 460925  Cd Length: 48  Bit Score: 40.25  E-value: 1.41e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 767952746  120 FNSEEFLKTRAPGDHQFYKQVLDTYMFHSFLKARLNRR 157
Cdd:pfam03455   1 FDKEAFLKSLPSDSRPFLSQFLETQMFNEFIEERLESS 38
 
Name Accession Description Interval E-value
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 91-153 8.33e-14

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 129037  Cd Length: 69  Bit Score: 66.93  E-value: 8.33e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767952746    91 NCQIQQTTLQLLVSIFRDVKNHLNY------EHRVFNSEEFLKTRAPGDHQFYKQVLDTYMFHSFLKAR 153
Cdd:smart00801   1 NDEIREAFLRFFVNLFGGYRNFLRElrkepgPVITFDKESFLKSRPSSERPFLSKFLETQMFSQFIEER 69
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 675-776 5.49e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 52.34  E-value: 5.49e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767952746 675 HSFKVGTAKVNCMVMADQNQ-VWVGSEDSVIYIINVHSMSCNKQLTAHCSSVTDLI-VQDGQEapsnVYSCSMDGMVLVW 752
Cdd:cd00200    3 RTLKGHTGGVTCVAFSPDGKlLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAaSADGTY----LASGSSDKTIRLW 78

                         90       100
                 ....*....|....*....|....
gi 767952746 753 NVSTLQVTSRFQLPRGGLTSIRLH 776
Cdd:cd00200   79 DLETGECVRTLTGHTSYVSSVAFS 102
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 638-842 2.04e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 50.41  E-value: 2.04e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767952746 638 GHLDPAEKVE--DAHPKLWCALSEGKVTVFNASS----WTIHQHsfkvgTAKVNCMVMADQNQVWVGS-EDSVIYIINVH 710
Cdd:cd00200   49 GHTGPVRDVAasADGTYLASGSSDKTIRLWDLETgecvRTLTGH-----TSYVSSVAFSPDGRILSSSsRDKTIKVWDVE 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767952746 711 SMSCNKQLTAHCSSVTDLIVQdgqeaPSN--VYSCSMDGMVLVWNVSTLQVTSRFQLPRGGLTSIRLHGGRLWCCTGNSI 788
Cdd:cd00200  124 TGKCLTTLRGHTDWVNSVAFS-----PDGtfVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSD 198

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 767952746 789 MVMKM----NGSLHQELKIEENFkdtstsflAFQLLPEEEQLWAACAGR-SEVYIWSLK 842
Cdd:cd00200  199 GTIKLwdlsTGKCLGTLRGHENG--------VNSVAFSPDGYLLASGSEdGTIRVWDLR 249
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 655-790 5.27e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 49.26  E-value: 5.27e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767952746 655 CALSEGKVTVFNASSW----TIHQHsfkvgTAKVNCM-VMADQNQVWVGSEDSVIYIINVHSMSCNKQLTAHCSSVTDLI 729
Cdd:cd00200  152 SSSQDGTIKLWDLRTGkcvaTLTGH-----TGEVNSVaFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVA 226

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767952746 730 VqdgqeAPSN--VYSCSMDGMVLVWNVSTLQVTSRFQLPRGGLTSIRLHGGRLWCCTG---NSIMV 790
Cdd:cd00200  227 F-----SPDGylLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGsadGTIRI 287
WD40 COG2319
WD40 repeat [General function prediction only];
660-773 6.36e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 49.52  E-value: 6.36e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767952746 660 GKVTVFNASSWTIhQHSFKVGTAKVNCMVMA-DQNQVWVGSEDSVIYIINVHSMSCNKQLTAHCSSVTDL-IVQDGQEap 737
Cdd:COG2319  268 GTVRLWDLATGEL-LRTLTGHSGGVNSVAFSpDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVaFSPDGKT-- 344

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 767952746 738 snVYSCSMDGMVLVWNVSTLQVTSRFQLPRGGLTSI 773
Cdd:COG2319  345 --LASGSDDGTVRLWDLATGELLRTLTGHTGAVTSV 378
WD40 COG2319
WD40 repeat [General function prediction only];
660-776 1.65e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 48.37  E-value: 1.65e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767952746 660 GKVTVFNASSWTIhQHSFKVGTAKVNCMVMA-DQNQVWVGSEDSVIYIINVHSMSCNKQLTAHCSSVTDLIV-QDGQEap 737
Cdd:COG2319  184 GTVRLWDLATGKL-LRTLTGHTGAVRSVAFSpDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFsPDGRL-- 260

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 767952746 738 snVYSCSMDGMVLVWNVSTLQVTSRFQLPRGGLTSIRLH 776
Cdd:COG2319  261 --LASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFS 297
WD40 COG2319
WD40 repeat [General function prediction only];
653-843 1.65e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 48.37  E-value: 1.65e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767952746 653 LWCALSEGKVTVFNASSWTIhQHSFKVGTAKVNCMVMA-DQNQVWVGSEDSVIYIINVHSMSCNKQLTAHCSSVTDL-IV 730
Cdd:COG2319  219 LASGSADGTVRLWDLATGKL-LRTLTGHSGSVRSVAFSpDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVaFS 297

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767952746 731 QDGQeapsNVYSCSMDGMVLVWNVSTLQVTSRFQLPRGGLTSIRLH--GGRL-WCCTGNSIMVMKMNGSlhQELKIEENF 807
Cdd:COG2319  298 PDGK----LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSpdGKTLaSGSDDGTVRLWDLATG--ELLRTLTGH 371

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 767952746 808 KDTSTSfLAFqlLPEEEQLWAACAGRSeVYIWSLKD 843
Cdd:COG2319  372 TGAVTS-VAF--SPDGRTLASGSADGT-VRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 658-753 2.70e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 46.94  E-value: 2.70e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767952746 658 SEGKVTVFNASSWTiHQHSFKVGTAKVNCmVMADQNQVWV--GSEDSVIYIINVHSMSCNKQLTAHCSSVTDL-IVQDGQ 734
Cdd:cd00200  197 SDGTIKLWDLSTGK-CLGTLRGHENGVNS-VAFSPDGYLLasGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLaWSPDGK 274

                         90
                 ....*....|....*....
gi 767952746 735 EapsnVYSCSMDGMVLVWN 753
Cdd:cd00200  275 R----LASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
660-776 2.71e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 47.60  E-value: 2.71e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767952746 660 GKVTVFNASSWTIhQHSFKVGTAKVNCMVM-ADQNQVWVGSEDSVIYIINVHSMSCNKQLTAHCSSVTDLIV-QDGQeap 737
Cdd:COG2319  142 GTVRLWDLATGKL-LRTLTGHSGAVTSVAFsPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFsPDGK--- 217

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 767952746 738 sNVYSCSMDGMVLVWNVSTLQVTSRFQLPRGGLTSIRLH 776
Cdd:COG2319  218 -LLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFS 255
dDENN pfam03455
dDENN domain; This region is always found associated with pfam02141. It is predicted to form a ...
 120-157 1.41e-04

dDENN domain; This region is always found associated with pfam02141. It is predicted to form a globular domain. Although not statistically supported it has been suggested that this domain may be similar to members of the Rho/Rac/Cdc42 GEF family. This N-terminal region of DENN folds into a longin module, consisting of a central antiparallel beta-sheet layered between helix H1 and helices H2 and H3 (strands S1-S5). Rab35 interacts with dDENN via residues in helix 1 and in the loop S3-S4.


Pssm-ID: 460925  Cd Length: 48  Bit Score: 40.25  E-value: 1.41e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 767952746  120 FNSEEFLKTRAPGDHQFYKQVLDTYMFHSFLKARLNRR 157
Cdd:pfam03455   1 FDKEAFLKSLPSDSRPFLSQFLETQMFNEFIEERLESS 38
WD40 COG2319
WD40 repeat [General function prediction only];
656-773 4.79e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 43.75  E-value: 4.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767952746 656 ALSEGKVTVFNASSwTIHQHSFKVGTAKVNCMVM-ADQNQVWVGSEDSVIYIINVHSMSCNKQLTAHCSSVTDLIV-QDG 733
Cdd:COG2319   96 ASADGTVRLWDLAT-GLLLRTLTGHTGAVRSVAFsPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFsPDG 174

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 767952746 734 QeapsNVYSCSMDGMVLVWNVSTLQVTSRFQLPRGGLTSI 773
Cdd:COG2319  175 K----LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV 210
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 714-788 5.24e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 40.01  E-value: 5.24e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767952746 714 CNKQLTAHCSSVTDLIVQDGQEapsNVYSCSMDGMVLVWNVSTLQVTSRFQLPRGGLTSIrlhggrLWCCTGNSI 788
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGK---LLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDV------AASADGTYL 66
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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