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Conserved domains on  [gi|1034591230|ref|XP_011520054|]
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uveal autoantigen with coiled-coil domains and ankyrin repeats isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
21-289 3.58e-38

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 145.10  E-value: 3.58e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230   21 FYNSALLMKLAQKGEGNLECNWKISDHAADWNKYDDRLMKAAERGDVEKVTSILAKKGVNPGKLDVEGRSVFHVVTSKGN 100
Cdd:COG0666     20 LLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGD 99

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  101 LECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHGASV 180
Cdd:COG0666    100 LEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADV 179

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  181 NAKDVDGRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLIKNGADISLLDALGHDSSYYA 260
Cdd:COG0666    180 NARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLA 259

                          250       260
                   ....*....|....*....|....*....
gi 1034591230  261 RIGDNLDILTLLKTASENTNKGRELWKKG 289
Cdd:COG0666    260 AAAGAALIVKLLLLALLLLAAALLDLLTL 288
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 565-1366 1.35e-19

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 95.89  E-value: 1.35e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  565 QLKDLKVKYEGASAEVGKLRNQIKQNEMivEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKL- 643
Cdd:TIGR02168  214 RYKELKAELRELELALLVLRLEELREEL--EELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELy 291

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  644 ALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQhvKPEEHEQVKSRLEqksgELGK 723
Cdd:TIGR02168  292 ALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEE--LKEELESLEAELE----ELEA 365

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  724 KITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEME 803
Cdd:TIGR02168  366 ELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAELKELQAELEEL 445

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  804 KLLLEndslsKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVP-- 881
Cdd:TIGR02168  446 EEELE-----ELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGLsg 520

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  882 --------VKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKD---------------KNEILKRNLENTQNQI 938
Cdd:TIGR02168  521 ilgvlselISVDEGYEAAIEAALGGRLQAVVVENLNAAKKAIAFLKQNElgrvtflpldsikgtEIQGNDREILKNIEGF 600

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  939 KAEYISLAEHEAK----MSSLSQSMRKVQD-SNAEILANYRKGQEEIVTL------------------HAEIKAQKKELD 995
Cdd:TIGR02168  601 LGVAKDLVKFDPKlrkaLSYLLGGVLVVDDlDNALELAKKLRPGYRIVTLdgdlvrpggvitggsaktNSSILERRREIE 680

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  996 TIQECIkvkyapivsfEECERKFKATEKELKDQLSEQTQKysvsEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSH 1075
Cdd:TIGR02168  681 ELEEKI----------EELEEKIAELEKALAELRKELEEL----EEELEQLRKELEELSRQISALRKDLARLEAEVEQLE 746

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1076 EMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEEL 1155
Cdd:TIGR02168  747 ERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERL 826

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1156 KSMQRCYEKEQQTVTKLHQLLE-----------NQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKL 1224
Cdd:TIGR02168  827 ESLERRIAATERRLEDLEEQIEelsedieslaaEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEELREL 906

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1225 QSEVQNTKQALKKLETRevvdLSKYKATKSDLETQISSLNEKLANL-NRKYEEVCEEVLHAKKKEISAKDEKELLHFSIE 1303
Cdd:TIGR02168  907 ESKRSELRRELEELREK----LAQLELRLEGLEVRIDNLQERLSEEySLTLEEAEALENKIEDDEEEARRRLKRLENKIK 982

                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034591230 1304 ----------QEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDV-ERLKQALNGLSQLTYTSG 1366
Cdd:TIGR02168  983 elgpvnlaaiEEYEELKERYDFLTAQKEDLTEAKETLEEAIEEIDREARERFKDTfDQVNENFQRVFPKLFGGG 1056
PLN02939 super family cl33600
transferase, transferring glycosyl groups
 271-623 1.11e-03

transferase, transferring glycosyl groups


The actual alignment was detected with superfamily member PLN02939:

Pssm-ID: 215507 [Multi-domain]  Cd Length: 977  Bit Score: 43.74  E-value: 1.11e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  271 LLKTASENTNKGRELWKKGPSLQQRNlTHMQDEVNVKSHQR-EHQNIQDLEI-ENEDLKERLRKIQQEQRI-LLDKVNGL 347
Cdd:PLN02939    65 LQSNTDENGQLENTSLRTVMELPQKS-TSSDDDHNRASMQRdEAIAAIDNEQqTNSKDGEQLSDFQLEDLVgMIQNAEKN 143

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  348 QLQLNEEVMVA-DDLE---SEREKL----------------KSLLAAKEKQHEESLRtiEALKNRFKYFESDHLGSGSHF 407
Cdd:PLN02939   144 ILLLNQARLQAlEDLEkilTEKEALqgkinilemrlsetdaRIKLAAQEKIHVEILE--EQLEKLRNELLIRGATEGLCV 221

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  408 SN--------RKEDMLLKQGQMYM----ADSQCTSPGIPAHMQSRSMLRPLELSLPSQTSYSENEILKkeLEAMRTFCES 475
Cdd:PLN02939   222 HSlskeldvlKEENMLLKDDIQFLkaelIEVAETEERVFKLEKERSLLDASLRELESKFIVAQEDVSK--LSPLQYDCWW 299

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  476 AKQDRLKLQNELAHKVAECKALALECERvkeDSDEQIKQLEDALKdvqkrmyesEGKVKQMQTHFLALkehltseaasgn 555
Cdd:PLN02939   300 EKVENLQDLLDRATNQVEKAALVLDQNQ---DLRDKVDKLEASLK---------EANVSKFSSYKVEL------------ 355

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034591230  556 hrlteeLKDQLKDLKVKYEGASAEVgklRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMERE 623
Cdd:PLN02939   356 ------LQQKLKLLEERLQASDHEI---HSYIQLYQESIKEFQDTLSKLKEESKKRSLEHPADDMPSE 414
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
21-289 3.58e-38

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 145.10  E-value: 3.58e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230   21 FYNSALLMKLAQKGEGNLECNWKISDHAADWNKYDDRLMKAAERGDVEKVTSILAKKGVNPGKLDVEGRSVFHVVTSKGN 100
Cdd:COG0666     20 LLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGD 99

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  101 LECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHGASV 180
Cdd:COG0666    100 LEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADV 179

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  181 NAKDVDGRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLIKNGADISLLDALGHDSSYYA 260
Cdd:COG0666    180 NARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLA 259

                          250       260
                   ....*....|....*....|....*....
gi 1034591230  261 RIGDNLDILTLLKTASENTNKGRELWKKG 289
Cdd:COG0666    260 AAAGAALIVKLLLLALLLLAAALLDLLTL 288
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 565-1366 1.35e-19

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 95.89  E-value: 1.35e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  565 QLKDLKVKYEGASAEVGKLRNQIKQNEMivEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKL- 643
Cdd:TIGR02168  214 RYKELKAELRELELALLVLRLEELREEL--EELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELy 291

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  644 ALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQhvKPEEHEQVKSRLEqksgELGK 723
Cdd:TIGR02168  292 ALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEE--LKEELESLEAELE----ELEA 365

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  724 KITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEME 803
Cdd:TIGR02168  366 ELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAELKELQAELEEL 445

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  804 KLLLEndslsKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVP-- 881
Cdd:TIGR02168  446 EEELE-----ELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGLsg 520

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  882 --------VKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKD---------------KNEILKRNLENTQNQI 938
Cdd:TIGR02168  521 ilgvlselISVDEGYEAAIEAALGGRLQAVVVENLNAAKKAIAFLKQNElgrvtflpldsikgtEIQGNDREILKNIEGF 600

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  939 KAEYISLAEHEAK----MSSLSQSMRKVQD-SNAEILANYRKGQEEIVTL------------------HAEIKAQKKELD 995
Cdd:TIGR02168  601 LGVAKDLVKFDPKlrkaLSYLLGGVLVVDDlDNALELAKKLRPGYRIVTLdgdlvrpggvitggsaktNSSILERRREIE 680

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  996 TIQECIkvkyapivsfEECERKFKATEKELKDQLSEQTQKysvsEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSH 1075
Cdd:TIGR02168  681 ELEEKI----------EELEEKIAELEKALAELRKELEEL----EEELEQLRKELEELSRQISALRKDLARLEAEVEQLE 746

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1076 EMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEEL 1155
Cdd:TIGR02168  747 ERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERL 826

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1156 KSMQRCYEKEQQTVTKLHQLLE-----------NQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKL 1224
Cdd:TIGR02168  827 ESLERRIAATERRLEDLEEQIEelsedieslaaEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEELREL 906

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1225 QSEVQNTKQALKKLETRevvdLSKYKATKSDLETQISSLNEKLANL-NRKYEEVCEEVLHAKKKEISAKDEKELLHFSIE 1303
Cdd:TIGR02168  907 ESKRSELRRELEELREK----LAQLELRLEGLEVRIDNLQERLSEEySLTLEEAEALENKIEDDEEEARRRLKRLENKIK 982

                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034591230 1304 ----------QEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDV-ERLKQALNGLSQLTYTSG 1366
Cdd:TIGR02168  983 elgpvnlaaiEEYEELKERYDFLTAQKEDLTEAKETLEEAIEEIDREARERFKDTfDQVNENFQRVFPKLFGGG 1056
PHA03095 PHA03095
ankyrin-like protein; Provisional
 68-251 1.76e-19

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 93.55  E-value: 1.76e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230   68 EKVTSILAKKGVNPGKLDVEGRSVFHV-VTSKG-NLECLNAILIHGVDITTSDTAGRNALHLAAKYGH--ALCLQKLLQY 143
Cdd:PHA03095   132 PKVIRLLLRKGADVNALDLYGMTPLAVlLKSRNaNVELLRLLIDAGADVYAVDDRFRSLLHHHLQSFKprARIVRELIRA 211

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  144 NCPTEHADLQGRTALHDAAM-ADCPSS-IQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNR 221
Cdd:PHA03095   212 GCDPAATDMLGNTPLHSMATgSSCKRSlVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGN 291

                          170       180       190
                   ....*....|....*....|....*....|
gi 1034591230  222 TALMLGCEYGCRDAVEVLIKNGADISLLDA 251
Cdd:PHA03095   292 TPLSLMVRNNNGRAVRAALAKNPSAETVAA 321
Ank_2 pfam12796
Ankyrin repeats (3 copies);
125-217 3.35e-18

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 80.93  E-value: 3.35e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  125 LHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHgASVNAKDvDGRTPLVLATQMSRPTICQ 204
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 1034591230  205 LLIDRGADVNSRD 217
Cdd:pfam12796   79 LLLEKGADINVKD 91
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
650-1239 1.60e-14

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 78.95  E-value: 1.60e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  650 EKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAqhvKPEEHEQVKSRLEQKSGELGKKITELT 729
Cdd:PRK03918   182 EKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREELEKLEKEVK---ELEELKEEIEELEKELESLEGSKRKLE 258

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  730 LKNQTLQKEIEKVYLDNKLLKEQAHNLtiemknhyvplkvsEDMKKSHDAIIddlnrKLLDVTQKYTEKKLEMEKLLlen 809
Cdd:PRK03918   259 EKIRELEERIEELKKEIEELEEKVKEL--------------KELKEKAEEYI-----KLSEFYEEYLDELREIEKRL--- 316

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  810 DSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCgEDQEKIHALTSENTNLKKMMSNQyvpvktheevk 889
Cdd:PRK03918   317 SRLEEEINGIEERIKELEEKEERLEELKKKLKELEKRLEELEERH-ELYEEAKAKKEELERLKKRLTGL----------- 384

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  890 mtlndTLAKTNRELLDVKKKFEDINQEFVKIKDKneilKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMrkVQDSNAEI 969
Cdd:PRK03918   385 -----TPEKLEKELEELEKAKEEIEEEISKITAR----IGELKKEIKELKKAIEELKKAKGKCPVCGREL--TEEHRKEL 453

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  970 LANYRKgqeEIvtlhAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFkATEKELKDQLSEQTQKYS-VSEEEVKKNKQ 1048
Cdd:PRK03918   454 LEEYTA---EL----KRIEKELKEIEEKERKLRKELRELEKVLKKESEL-IKLKELAEQLKELEEKLKkYNLEELEKKAE 525

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1049 ENDKLKKEIFTLQKDLRDktvlIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQ 1128
Cdd:PRK03918   526 EYEKLKEKLIKLKGEIKS----LKKELEKLEELKKKLAELEKKLDELEEELAELLKELEELGFESVEELEERLKELEPFY 601

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1129 KQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLEnQKNSSVPLAEHLQIKEAF---EKEVGIIKA 1205
Cdd:PRK03918   602 NEYLELKDAEKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELE-ELEKKYSEEEYEELREEYlelSRELAGLRA 680

                          570       580       590
                   ....*....|....*....|....*....|....
gi 1034591230 1206 SLREKEEESQNKMEEVSKLQSEVQNTKQALKKLE 1239
Cdd:PRK03918   681 ELEELEKRREEIKKTLEKLKEELEEREKAKKELE 714
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 462-1231 3.09e-11

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 68.22  E-value: 3.09e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  462 LKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLedalkdvQKRMYESEGKVKQMQTHFL 541
Cdd:pfam15921  122 MQMERDAMADIRRRESQSQEDLRNQLQNTVHELEAAKCLKEDMLEDSNTQIEQL-------RKMMLSHEGVLQEIRSILV 194

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  542 ALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIE-----ENKRLQKELS 616
Cdd:pfam15921  195 DFEEASGKKIYEHDSMSTMHFRSLGSAISKILRELDTEISYLKGRIFPVEDQLEALKSESQNKIElllqqHQDRIEQLIS 274

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  617 MCEMEREKKGRKVTEMEGQAKELSAKLalsipaekfENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKA 696
Cdd:pfam15921  275 EHEVEITGLTEKASSARSQANSIQSQL---------EIIQEQARNQNSMYMRQLSDLESTVSQLRSELREAKRMYEDKIE 345

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  697 KLAQHVKPEEHEQVKSRLE-----QKSGELGKKITELTLKNQTLQKEIEkvyldnkLLKEQAHNLTiemknhyvplkvse 771
Cdd:pfam15921  346 ELEKQLVLANSELTEARTErdqfsQESGNLDDQLQKLLADLHKREKELS-------LEKEQNKRLW-------------- 404

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  772 DMKKSHDAIIDDLNRKLldvtqkytekklemeklllenDSLSKDVSRLETVfvppekhekeIIALKSNIV-ELKKQLSEL 850
Cdd:pfam15921  405 DRDTGNSITIDHLRREL---------------------DDRNMEVQRLEAL----------LKAMKSECQgQMERQMAAI 453

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  851 KKKcGEDQEKIHALTSENTNLKKMMSnqyvpvKTHEEV---KMTLND---TLAKTNRELLDVKKKFEDINQEFVKIKDKN 924
Cdd:pfam15921  454 QGK-NESLEKVSSLTAQLESTKEMLR------KVVEELtakKMTLESserTVSDLTASLQEKERAIEATNAEITKLRSRV 526

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  925 EILKRNLENTQNQikAEYISLAEHEAKMSSLSQSMRkvqDSNAEILANYRKGQEEIVTLHAEIK-AQKKELDTIQECIKV 1003
Cdd:pfam15921  527 DLKLQELQHLKNE--GDHLRNVQTECEALKLQMAEK---DKVIEILRQQIENMTQLVGQHGRTAgAMQVEKAQLEKEIND 601

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1004 KYAPIVSFEECERKFKATEKELKDQLS----EQTQKYSVSEEE---VKKNKQENDKLKKEIFTLQKDLRDKTVLIE---- 1072
Cdd:pfam15921  602 RRLELQEFKILKDKKDAKIRELEARVSdlelEKVKLVNAGSERlraVKDIKQERDQLLNEVKTSRNELNSLSEDYEvlkr 681

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1073 ----KSHEMERAlsrkTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHvplEQVEALKKSlngtI 1148
Cdd:pfam15921  682 nfrnKSEEMETT----TNKLKMQLKSAQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKR---GQIDALQSK----I 750

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1149 ENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEK---------EVGIIKASLREKEEESQNKME 1219
Cdd:pfam15921  751 QFLEEAMTNANKEKHFLKEEKNKLSQELSTVATEKNKMAGELEVLRSQERrlkekvanmEVALDKASLQFAECQDIIQRQ 830

                          810
                   ....*....|..
gi 1034591230 1220 EVSKLQSEVQNT 1231
Cdd:pfam15921  831 EQESVRLKLQHT 842
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1061-1434 9.80e-10

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 63.42  E-value: 9.80e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1061 QKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEAL 1140
Cdd:COG1196    221 ELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARL 300

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1141 KKSLNGTIENLKEELKSMQRcYEKEQQTVTKLHQLLENQknssvpLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEE 1220
Cdd:COG1196    301 EQDIARLEERRRELEERLEE-LEEELAELEEELEELEEE------LEELEEELEEAEEELEEAEAELAEAEEALLEAEAE 373

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1221 VSKLQSEVQNTKQALKKLETREVVDLSKYKAtksdLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAkdekellhf 1300
Cdd:COG1196    374 LAEAEEELEELAEELLEALRAAAELAAQLEE----LEEAEEALLERLERLEEELEELEEALAELEEEEEEE--------- 440

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1301 siEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTytsgnpTKRQSQLIDTLQ 1380
Cdd:COG1196    441 --EEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAE------ADYEGFLEGVKA 512

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1034591230 1381 HQVKSLEQQLADADRQHQEVIAIYRTHLLSAAQGHMDEDVQEALLQIIQMRQGL 1434
Cdd:COG1196    513 ALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEYL 566
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 125-253 2.83e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 51.94  E-value: 2.83e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  125 LHLAAKYGHALCLQKLLQYNcpteHADLQ-----GRTALHDAAMADCPSSIQLLCDhgasvNAKDV----------DGRT 189
Cdd:cd22192     21 LLLAAKENDVQAIKKLLKCP----SCDLFqrgalGETALHVAALYDNLEAAVVLME-----AAPELvnepmtsdlyQGET 91

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034591230  190 PLVLATQMSRPTICQLLIDRGADVNSRD------KQNRTALMLGCEY--------GCRDAVEVLIKNGADISLLDALG 253
Cdd:cd22192     92 ALHIAVVNQNLNLVRELIARGADVVSPRatgtffRPGPKNLIYYGEHplsfaacvGNEEIVRLLIEHGADIRAQDSLG 169
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 768-1141 3.61e-05

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 48.47  E-value: 3.61e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  768 KVSEDMKKSHDAIIDDLNRKLLDVTQKYTeKKLEMEKLLLENDSLSKDVSRLETVFvppEKHEKEIIALKSNIVELKKQL 847
Cdd:NF033838    73 EIQKSLDKRKHTQNVALNKKLSDIKTEYL-YELNVLKEKSEAELTSKTKKELDAAF---EQFKKDTLEPGKKVAEATKKV 148

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  848 SELKKKCGEDQEKIHALTSENTnlkkmmsnqyvpVKTHEEVKMTLNDTLAKTNRELLDVKKKF----EDINQEFVKIKDK 923
Cdd:NF033838   149 EEAEKKAKDQKEEDRRNYPTNT------------YKTLELEIAESDVEVKKAELELVKEEAKEprdeEKIKQAKAKVESK 216

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  924 NEILKRnLENTQNQIKAeyislAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKV 1003
Cdd:NF033838   217 KAEATR-LEKIKTDREK-----AEEEAKRRADAKLKEAVEKNVATSEQDKPKRRAKRGVLGEPATPDKKENDAKSSDSSV 290

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1004 --------KYAPIVSFEECERKFKATEKELKDQLSEQTQKY----------SVSEEEVKKNKQENDKLKKEiftlQKDLR 1065
Cdd:NF033838   291 geetlpspSLKPEKKVAEAEKKVEEAKKKAKDQKEEDRRNYptntyktlelEIAESDVKVKEAELELVKEE----AKEPR 366

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1066 DKTVLIEKSHEMERALSRKT------DELNKQLKDLSQKYTEVKNVKEKLVEEnaKQTSEILAVQNLLQKQHVPLEQVEA 1139
Cdd:NF033838   367 NEEKIKQAKAKVESKKAEATrlekikTDRKKAEEEAKRKAAEEDKVKEKPAEQ--PQPAPAPQPEKPAPKPEKPAEQPKA 444


                   ..
gi 1034591230 1140 LK 1141
Cdd:NF033838   445 EK 446
PLN02939 PLN02939
transferase, transferring glycosyl groups
 271-623 1.11e-03

transferase, transferring glycosyl groups


Pssm-ID: 215507 [Multi-domain]  Cd Length: 977  Bit Score: 43.74  E-value: 1.11e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  271 LLKTASENTNKGRELWKKGPSLQQRNlTHMQDEVNVKSHQR-EHQNIQDLEI-ENEDLKERLRKIQQEQRI-LLDKVNGL 347
Cdd:PLN02939    65 LQSNTDENGQLENTSLRTVMELPQKS-TSSDDDHNRASMQRdEAIAAIDNEQqTNSKDGEQLSDFQLEDLVgMIQNAEKN 143

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  348 QLQLNEEVMVA-DDLE---SEREKL----------------KSLLAAKEKQHEESLRtiEALKNRFKYFESDHLGSGSHF 407
Cdd:PLN02939   144 ILLLNQARLQAlEDLEkilTEKEALqgkinilemrlsetdaRIKLAAQEKIHVEILE--EQLEKLRNELLIRGATEGLCV 221

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  408 SN--------RKEDMLLKQGQMYM----ADSQCTSPGIPAHMQSRSMLRPLELSLPSQTSYSENEILKkeLEAMRTFCES 475
Cdd:PLN02939   222 HSlskeldvlKEENMLLKDDIQFLkaelIEVAETEERVFKLEKERSLLDASLRELESKFIVAQEDVSK--LSPLQYDCWW 299

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  476 AKQDRLKLQNELAHKVAECKALALECERvkeDSDEQIKQLEDALKdvqkrmyesEGKVKQMQTHFLALkehltseaasgn 555
Cdd:PLN02939   300 EKVENLQDLLDRATNQVEKAALVLDQNQ---DLRDKVDKLEASLK---------EANVSKFSSYKVEL------------ 355

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034591230  556 hrlteeLKDQLKDLKVKYEGASAEVgklRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMERE 623
Cdd:PLN02939   356 ------LQQKLKLLEERLQASDHEI---HSYIQLYQESIKEFQDTLSKLKEESKKRSLEHPADDMPSE 414
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 457-754 2.65e-03

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 42.31  E-value: 2.65e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  457 SENEILKKELEAMRTFCESAKQDRLklqnELAHKVAECKALALECERVKEDSDEQIKQ--LEDALKDVQKRMYESEGKVK 534
Cdd:NF033838   111 SEAELTSKTKKELDAAFEQFKKDTL----EPGKKVAEATKKVEEAEKKAKDQKEEDRRnyPTNTYKTLELEIAESDVEVK 186

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  535 QMQTHFLALKEHLTSEaasgnhrlteelKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGklIEENKRLQKE 614
Cdd:NF033838   187 KAELELVKEEAKEPRD------------EEKIKQAKAKVESKKAEATRLEKIKTDREKAEEEAKRRAD--AKLKEAVEKN 252

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  615 LSMCEMEREKKGRKVTEMEGQA----KELSAKLALSIPAEkfENMKS-SLSNE--VNEKAKKLVEMER------------ 675
Cdd:NF033838   253 VATSEQDKPKRRAKRGVLGEPAtpdkKENDAKSSDSSVGE--ETLPSpSLKPEkkVAEAEKKVEEAKKkakdqkeedrrn 330

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  676 ---------EHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKkiteltlknqtlqkeIEKVYLDN 746
Cdd:NF033838   331 yptntyktlELEIAESDVKVKEAELELVKEEAKEPRNEEKIKQAKAKVESKKAEATR---------------LEKIKTDR 395


                   ....*...
gi 1034591230  747 KLLKEQAH 754
Cdd:NF033838   396 KKAEEEAK 403
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 50-285 4.62e-03

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 41.61  E-value: 4.62e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230   50 DWNKYDDRLMKAAERGDVekvtSILAKKGVNPGKLDVE-----GRSVFHVVTSKGNLECLNAILI-HGVDITTSDTAgrn 123
Cdd:TIGR00870   13 PLSDEEKAFLPAAERGDL----ASVYRDLEEPKKLNINcpdrlGRSALFVAAIENENLELTELLLnLSCRGAVGDTL--- 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  124 aLHLAAKyghalclqkllqyncptEHADLQGRTALHDAAMADCPSSIQLlcdhgasVNAKDVD----GRTPLVLATQMSR 199
Cdd:TIGR00870   86 -LHAISL-----------------EYVDAVEAILLHLLAAFRKSGPLEL-------ANDQYTSeftpGITALHLAAHRQN 140

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  200 PTICQLLIDRGADVNSR-------DKQNRTALMLGcEY--------GCRDAVEVLIKNGADISLLDALGHdssyyarigd 264
Cdd:TIGR00870  141 YEIVKLLLERGASVPARacgdffvKSQGVDSFYHG-ESplnaaaclGSPSIVALLSEDPADILTADSLGN---------- 209

                          250       260
                   ....*....|....*....|.
gi 1034591230  265 nlDILTLLKTASENTNKGREL 285
Cdd:TIGR00870  210 --TLLHLLVMENEFKAEYEEL 228
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 310-741 4.75e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 41.46  E-value: 4.75e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  310 QREHQNIQDLEIENEDLKERLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIEAL 389
Cdd:COG1196    396 AELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALL 475

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  390 KNrfkyfESDHLGSGSHFSNRKEDMLLKQGQMYMADSQctSPGIPAHMQSRSMLRPLELSLPSQTSYSENEILKKELEAM 469
Cdd:COG1196    476 EA-----ALAELLEELAEAAARLLLLLEAEADYEGFLE--GVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAAL 548

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  470 RTFCESAKQDRLKLQNEL-AHKVAECKALALECERVKEDSDEQIKQLED----ALKDVQKRMYESEGKVKQMQTHFLALK 544
Cdd:COG1196    549 QNIVVEDDEVAAAAIEYLkAAKAGRATFLPLDKIRARAALAAALARGAIgaavDLVASDLREADARYYVLGDTLLGRTLV 628

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  545 EHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREK 624
Cdd:COG1196    629 AARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERE 708

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  625 KGRKVTEMEGQAKELSAKL-ALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELE-----NVKAkl 698
Cdd:COG1196    709 LAEAEEERLEEELEEEALEeQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELERLEREIEalgpvNLLA-- 786

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|...
gi 1034591230  699 aqhvkPEEHEQVKSRLEqksgelgkkitELTLKNQTLQKEIEK 741
Cdd:COG1196    787 -----IEEYEELEERYD-----------FLSEQREDLEEARET 813
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
21-289 3.58e-38

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 145.10  E-value: 3.58e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230   21 FYNSALLMKLAQKGEGNLECNWKISDHAADWNKYDDRLMKAAERGDVEKVTSILAKKGVNPGKLDVEGRSVFHVVTSKGN 100
Cdd:COG0666     20 LLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGD 99

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  101 LECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHGASV 180
Cdd:COG0666    100 LEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADV 179

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  181 NAKDVDGRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLIKNGADISLLDALGHDSSYYA 260
Cdd:COG0666    180 NARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLA 259

                          250       260
                   ....*....|....*....|....*....
gi 1034591230  261 RIGDNLDILTLLKTASENTNKGRELWKKG 289
Cdd:COG0666    260 AAAGAALIVKLLLLALLLLAAALLDLLTL 288
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
41-281 2.47e-37

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 142.79  E-value: 2.47e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230   41 NWKISDHAADWNKYDDRLMKAAERGDVEKVTSILAKKGVNPGKLDVEGRSVFHVVTSKGNLECLNAILIHGVDITTSDTA 120
Cdd:COG0666      7 LLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDG 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  121 GRNALHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRP 200
Cdd:COG0666     87 GNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNL 166

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  201 TICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLIKNGADISLLDALGHDSSYYARIGDNLDILTLLKTASENTN 280
Cdd:COG0666    167 EIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLN 246


                   .
gi 1034591230  281 K 281
Cdd:COG0666    247 A 247
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
73-272 3.99e-29

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 118.90  E-value: 3.99e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230   73 ILAKKGVNPGKLDVEGRSVFHVVTSKGNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHADL 152
Cdd:COG0666      6 LLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDD 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  153 QGRTALHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGC 232
Cdd:COG0666     86 GGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGN 165

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 1034591230  233 RDAVEVLIKNGADISLLDALGHDSSYYARIGDNLDILTLL 272
Cdd:COG0666    166 LEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLL 205
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
22-224 2.09e-21

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 96.18  E-value: 2.09e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230   22 YNSALLMKLAQKGegNLECNWKISDHAADWNKYDDR----LMKAAERGDVEKVTsILAKKGVNPGKLDVEGRSVFHVVTS 97
Cdd:COG0666     86 GGNTLLHAAARNG--DLEIVKLLLEAGADVNARDKDgetpLHLAAYNGNLEIVK-LLLEAGADVNAQDNDGNTPLHLAAA 162

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230   98 KGNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHG 177
Cdd:COG0666    163 NGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAG 242

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*..
gi 1034591230  178 ASVNAKDVDGRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTAL 224
Cdd:COG0666    243 ADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 565-1366 1.35e-19

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 95.89  E-value: 1.35e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  565 QLKDLKVKYEGASAEVGKLRNQIKQNEMivEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKL- 643
Cdd:TIGR02168  214 RYKELKAELRELELALLVLRLEELREEL--EELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELy 291

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  644 ALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQhvKPEEHEQVKSRLEqksgELGK 723
Cdd:TIGR02168  292 ALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEE--LKEELESLEAELE----ELEA 365

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  724 KITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEME 803
Cdd:TIGR02168  366 ELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAELKELQAELEEL 445

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  804 KLLLEndslsKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVP-- 881
Cdd:TIGR02168  446 EEELE-----ELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGLsg 520

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  882 --------VKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKD---------------KNEILKRNLENTQNQI 938
Cdd:TIGR02168  521 ilgvlselISVDEGYEAAIEAALGGRLQAVVVENLNAAKKAIAFLKQNElgrvtflpldsikgtEIQGNDREILKNIEGF 600

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  939 KAEYISLAEHEAK----MSSLSQSMRKVQD-SNAEILANYRKGQEEIVTL------------------HAEIKAQKKELD 995
Cdd:TIGR02168  601 LGVAKDLVKFDPKlrkaLSYLLGGVLVVDDlDNALELAKKLRPGYRIVTLdgdlvrpggvitggsaktNSSILERRREIE 680

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  996 TIQECIkvkyapivsfEECERKFKATEKELKDQLSEQTQKysvsEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSH 1075
Cdd:TIGR02168  681 ELEEKI----------EELEEKIAELEKALAELRKELEEL----EEELEQLRKELEELSRQISALRKDLARLEAEVEQLE 746

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1076 EMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEEL 1155
Cdd:TIGR02168  747 ERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERL 826

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1156 KSMQRCYEKEQQTVTKLHQLLE-----------NQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKL 1224
Cdd:TIGR02168  827 ESLERRIAATERRLEDLEEQIEelsedieslaaEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEELREL 906

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1225 QSEVQNTKQALKKLETRevvdLSKYKATKSDLETQISSLNEKLANL-NRKYEEVCEEVLHAKKKEISAKDEKELLHFSIE 1303
Cdd:TIGR02168  907 ESKRSELRRELEELREK----LAQLELRLEGLEVRIDNLQERLSEEySLTLEEAEALENKIEDDEEEARRRLKRLENKIK 982

                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034591230 1304 ----------QEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDV-ERLKQALNGLSQLTYTSG 1366
Cdd:TIGR02168  983 elgpvnlaaiEEYEELKERYDFLTAQKEDLTEAKETLEEAIEEIDREARERFKDTfDQVNENFQRVFPKLFGGG 1056
PHA03095 PHA03095
ankyrin-like protein; Provisional
 68-251 1.76e-19

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 93.55  E-value: 1.76e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230   68 EKVTSILAKKGVNPGKLDVEGRSVFHV-VTSKG-NLECLNAILIHGVDITTSDTAGRNALHLAAKYGH--ALCLQKLLQY 143
Cdd:PHA03095   132 PKVIRLLLRKGADVNALDLYGMTPLAVlLKSRNaNVELLRLLIDAGADVYAVDDRFRSLLHHHLQSFKprARIVRELIRA 211

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  144 NCPTEHADLQGRTALHDAAM-ADCPSS-IQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNR 221
Cdd:PHA03095   212 GCDPAATDMLGNTPLHSMATgSSCKRSlVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGN 291

                          170       180       190
                   ....*....|....*....|....*....|
gi 1034591230  222 TALMLGCEYGCRDAVEVLIKNGADISLLDA 251
Cdd:PHA03095   292 TPLSLMVRNNNGRAVRAALAKNPSAETVAA 321
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
104-272 1.05e-18

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 88.47  E-value: 1.05e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  104 LNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHGASVNAK 183
Cdd:COG0666      4 LLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAK 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  184 DVDGRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLIKNGADISLLDALGHDSSYYARIG 263
Cdd:COG0666     84 DDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAAN 163


                   ....*....
gi 1034591230  264 DNLDILTLL 272
Cdd:COG0666    164 GNLEIVKLL 172
Ank_2 pfam12796
Ankyrin repeats (3 copies);
125-217 3.35e-18

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 80.93  E-value: 3.35e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  125 LHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHgASVNAKDvDGRTPLVLATQMSRPTICQ 204
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 1034591230  205 LLIDRGADVNSRD 217
Cdd:pfam12796   79 LLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
92-184 3.36e-17

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 77.85  E-value: 3.36e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230   92 FHVVTSKGNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEhaDLQGRTALHDAAMADCPSSIQ 171
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNL--KDNGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 1034591230  172 LLCDHGASVNAKD 184
Cdd:pfam12796   79 LLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
158-250 2.10e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 75.54  E-value: 2.10e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  158 LHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLIDRgADVNSRDkQNRTALMLGCEYGCRDAVE 237
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 1034591230  238 VLIKNGADISLLD 250
Cdd:pfam12796   79 LLLEKGADINVKD 91
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 792-1434 1.57e-15

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 82.41  E-value: 1.57e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  792 TQKYTEKKLEMEKLLLENDSLSKD--VSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENT 869
Cdd:TIGR02168  212 AERYKELKAELRELELALLVLRLEelREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELY 291

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  870 NLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHE 949
Cdd:TIGR02168  292 ALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELE 371

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  950 AKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVS--FEECERKFKATEKELKD 1027
Cdd:TIGR02168  372 SRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEaeLKELQAELEELEEELEE 451

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1028 QLSEQTQKysvsEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKE 1107
Cdd:TIGR02168  452 LQEELERL----EEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGLSGILGVLSE 527

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1108 KL-VEENAKQTSEIL---AVQNLL-QKQHVPLEQVEALKKSLNG-------------TIENLKEELKSMQRCYEKEQ--- 1166
Cdd:TIGR02168  528 LIsVDEGYEAAIEAAlggRLQAVVvENLNAAKKAIAFLKQNELGrvtflpldsikgtEIQGNDREILKNIEGFLGVAkdl 607

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1167 -QTVTKLHQLLENQKNSSVP---LAEHLQIKEAFEKEVGII--------------------KASLREKEEESQNKMEEVS 1222
Cdd:TIGR02168  608 vKFDPKLRKALSYLLGGVLVvddLDNALELAKKLRPGYRIVtldgdlvrpggvitggsaktNSSILERRREIEELEEKIE 687

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1223 KLQSEVQNTKQALKKLETREV---VDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLH 1299
Cdd:TIGR02168  688 ELEEKIAELEKALAELRKELEeleEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELE 767

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1300 FSI-----------------EQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLt 1362
Cdd:TIGR02168  768 ERLeeaeeelaeaeaeieelEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQ- 846

                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034591230 1363 ytsgnpTKRQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIYRT-----HLLSAAQGHMDEDVQEALLQIIQMRQGL 1434
Cdd:TIGR02168  847 ------IEELSEDIESLAAEIEELEELIEELESELEALLNERASleealALLRSELEELSEELRELESKRSELRREL 917
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 709-1347 2.31e-15

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 81.61  E-value: 2.31e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  709 QVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKL 788
Cdd:TIGR04523  117 EQKNKLEVELNKLEKQKKENKKNIDKFLTEIKKKEKELEKLNNKYNDLKKQKEELENELNLLEKEKLNIQKNIDKIKNKL 196

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  789 LDVTQKYTEKKLEMEKllleNDSLSKDVSRLEtvfvppekheKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSEN 868
Cdd:TIGR04523  197 LKLELLLSNLKKKIQK----NKSLESQISELK----------KQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQ 262

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  869 TNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKfedinqefvKIKDKNEILKRNLENTQNQIKAEYISLAEH 948
Cdd:TIGR04523  263 NKIKKQLSEKQKELEQNNKKIKELEKQLNQLKSEISDLNNQ---------KEQDWNKELKSELKNQEKKLEEIQNQISQN 333

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  949 EAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQ 1028
Cdd:TIGR04523  334 NKIISQLNEQISQLKKELTNSESENSEKQRELEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQ 413

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1029 LSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKshemeraLSRKTDELNKQLKDLSQKYTEVKNVKEK 1108
Cdd:TIGR04523  414 IKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVKELIIKN-------LDNTRESLETQLKVLSRSINKIKQNLEQ 486

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1109 LVEENAKQTSEILAVQNLlqkqhvpleqvealKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKnssvplae 1188
Cdd:TIGR04523  487 KQKELKSKEKELKKLNEE--------------KKELEEKVKDLTKKISSLKEKIEKLESEKKEKESKISDLE-------- 544

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1189 hlqiKEAFEKEVGIIKASLrekEEESQNKMEEVSKLQSEVQNTKQALKKLETrevvDLSKYKATKSDLETQISSLNEKLA 1268
Cdd:TIGR04523  545 ----DELNKDDFELKKENL---EKEIDEKNKEIEELKQTQKSLKKKQEEKQE----LIDQKEKEKKDLIKEIEEKEKKIS 613

                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034591230 1269 NLNRKYEEVCEEvlhaKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIeakdNKITELLND 1347
Cdd:TIGR04523  614 SLEKELEKAKKE----NEKLSSIIKNIKSKKNKLKQEVKQIKETIKEIRNKWPEIIKKIKESKTKI----DDIIELMKD 684
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
650-1239 1.60e-14

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 78.95  E-value: 1.60e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  650 EKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAqhvKPEEHEQVKSRLEQKSGELGKKITELT 729
Cdd:PRK03918   182 EKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREELEKLEKEVK---ELEELKEEIEELEKELESLEGSKRKLE 258

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  730 LKNQTLQKEIEKVYLDNKLLKEQAHNLtiemknhyvplkvsEDMKKSHDAIIddlnrKLLDVTQKYTEKKLEMEKLLlen 809
Cdd:PRK03918   259 EKIRELEERIEELKKEIEELEEKVKEL--------------KELKEKAEEYI-----KLSEFYEEYLDELREIEKRL--- 316

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  810 DSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCgEDQEKIHALTSENTNLKKMMSNQyvpvktheevk 889
Cdd:PRK03918   317 SRLEEEINGIEERIKELEEKEERLEELKKKLKELEKRLEELEERH-ELYEEAKAKKEELERLKKRLTGL----------- 384

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  890 mtlndTLAKTNRELLDVKKKFEDINQEFVKIKDKneilKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMrkVQDSNAEI 969
Cdd:PRK03918   385 -----TPEKLEKELEELEKAKEEIEEEISKITAR----IGELKKEIKELKKAIEELKKAKGKCPVCGREL--TEEHRKEL 453

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  970 LANYRKgqeEIvtlhAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFkATEKELKDQLSEQTQKYS-VSEEEVKKNKQ 1048
Cdd:PRK03918   454 LEEYTA---EL----KRIEKELKEIEEKERKLRKELRELEKVLKKESEL-IKLKELAEQLKELEEKLKkYNLEELEKKAE 525

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1049 ENDKLKKEIFTLQKDLRDktvlIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQ 1128
Cdd:PRK03918   526 EYEKLKEKLIKLKGEIKS----LKKELEKLEELKKKLAELEKKLDELEEELAELLKELEELGFESVEELEERLKELEPFY 601

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1129 KQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLEnQKNSSVPLAEHLQIKEAF---EKEVGIIKA 1205
Cdd:PRK03918   602 NEYLELKDAEKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELE-ELEKKYSEEEYEELREEYlelSRELAGLRA 680

                          570       580       590
                   ....*....|....*....|....*....|....
gi 1034591230 1206 SLREKEEESQNKMEEVSKLQSEVQNTKQALKKLE 1239
Cdd:PRK03918   681 ELEELEKRREEIKKTLEKLKEELEEREKAKKELE 714
PTZ00121 PTZ00121
MAEBL; Provisional
 486-1293 1.71e-14

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 79.41  E-value: 1.71e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  486 ELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKehltseaASGNHRLTEELKDQ 565
Cdd:PTZ00121  1167 EEARKAEDAKKAEAARKAEEVRKAEELRKAEDARKAEAARKAEEERKAEEARKAEDAKK-------AEAVKKAEEAKKDA 1239

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  566 LKDLKVKYEGASAEVGKLRN-QIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLA 644
Cdd:PTZ00121  1240 EEAKKAEEERNNEEIRKFEEaRMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKADEAKKKAEEAKKADE 1319

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  645 LSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKK 724
Cdd:PTZ00121  1320 AKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKK 1399

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  725 ITELTLKNQTLQKEIEKvyldnKLLKEQAHNLTIEMKnhyvplKVSEDMKKSHDAIIDDLNRKLLDVTQKYTE--KKLEM 802
Cdd:PTZ00121  1400 AEEDKKKADELKKAAAA-----KKKADEAKKKAEEKK------KADEAKKKAEEAKKADEAKKKAEEAKKAEEakKKAEE 1468

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  803 EKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNiVELKKQLSELKKkcGEDQEKIHALTSENTNLKKMMSNQYVPV 882
Cdd:PTZ00121  1469 AKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKA-AEAKKKADEAKK--AEEAKKADEAKKAEEAKKADEAKKAEEK 1545

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  883 KTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKV 962
Cdd:PTZ00121  1546 KKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEEL 1625

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  963 QDSNAEilanyRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEEcERKFKAteKELKDQLSEQTQKysvsEEE 1042
Cdd:PTZ00121  1626 KKAEEE-----KKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAE-EDKKKA--EEAKKAEEDEKKA----AEA 1693

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1043 VKKNKQEndklKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKnvkeklVEENAKQTSEILA 1122
Cdd:PTZ00121  1694 LKKEAEE----AKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEAK------KDEEEKKKIAHLK 1763

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1123 VQNLLQKQHVPLEQVEALKKSLNgtienlKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGI 1202
Cdd:PTZ00121  1764 KEEEKKAEEIRKEKEAVIEEELD------EEDEKRRMEVDKKIKDIFDNFANIIEGGKEGNLVINDSKEMEDSAIKEVAD 1837

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1203 IKASLREKEEESQNKMEEVSKLQSEVQNTKQALKK--------LETREVVDLSKyKATKSDLETQISSLNEKLAN----- 1269
Cdd:PTZ00121  1838 SKNMQLEEADAFEKHKFNKNNENGEDGNKEADFNKekdlkeddEEEIEEADEIE-KIDKDDIEREIPNNNMAGKNndiid 1916

                          810       820       830
                   ....*....|....*....|....*....|..
gi 1034591230 1270 --------LNRKYEEVCEEVLHAKKKEISAKD 1293
Cdd:PTZ00121  1917 dkldkdeyIKRDAEETREEIIKISKKDMCIND 1948
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
560-1160 8.68e-14

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 76.64  E-value: 8.68e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  560 EELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEF---KRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQA 636
Cdd:PRK03918   203 EEVLREINEISSELPELREELEKLEKEVKELEELKEEIeelEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKV 282

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  637 KELsaklalsipaekfenmksslsNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLaqhvkpEEHEQVKSRLEQ 716
Cdd:PRK03918   283 KEL---------------------KELKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEI------NGIEERIKELEE 335

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  717 KSGELGkkitELTLKNQTLQKEIEKVYLDNKLLkEQAHNLTIEMKNHyvplkvsedMKKSHDAIIDDLNRKLLDVTQKYT 796
Cdd:PRK03918   336 KEERLE----ELKKKLKELEKRLEELEERHELY-EEAKAKKEELERL---------KKRLTGLTPEKLEKELEELEKAKE 401

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  797 EKKLEMEKLllendslskdvsrletvfvppekhEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTnlKKMMS 876
Cdd:PRK03918   402 EIEEEISKI------------------------TARIGELKKEIKELKKAIEELKKAKGKCPVCGRELTEEHR--KELLE 455

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  877 NQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDiNQEFVKIKDKNEILKrNLENTQNQIKAEYISLAEHEakmssls 956
Cdd:PRK03918   456 EYTAELKRIEKELKEIEEKERKLRKELRELEKVLKK-ESELIKLKELAEQLK-ELEEKLKKYNLEELEKKAEE------- 526

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  957 qsmrkvqdsnaeilanYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKyapivsfEECERKFKATEKELKDQLSEQTQKY 1036
Cdd:PRK03918   527 ----------------YEKLKEKLIKLKGEIKSLKKELEKLEELKKKL-------AELEKKLDELEEELAELLKELEELG 583

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1037 SVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKL-VEENAK 1115
Cdd:PRK03918   584 FESVEELEERLKELEPFYNEYLELKDAEKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELEELEKKYsEEEYEE 663

                          570       580       590       600
                   ....*....|....*....|....*....|....*....|....*
gi 1034591230 1116 QTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQR 1160
Cdd:PRK03918   664 LREEYLELSRELAGLRAELEELEKRREEIKKTLEKLKEELEEREK 708
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 325-1157 1.09e-13

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 76.63  E-value: 1.09e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  325 DLKERLRKIQQeqRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFESDHLGSG 404
Cdd:TIGR02168  217 ELKAELRELEL--ALLVLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALA 294

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  405 SHFSNRKEDMLLKQGQMYMADSQctspgipahmqsrsmlrPLELSLPSQTSYSENEILKKELEAMRTFCESAKQDRLKLQ 484
Cdd:TIGR02168  295 NEISRLEQQKQILRERLANLERQ-----------------LEELEAQLEELESKLDELAEELAELEEKLEELKEELESLE 357

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  485 NELAHKVAECKALalecERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTseaasgnhRLTEELKD 564
Cdd:TIGR02168  358 AELEELEAELEEL----ESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRE--------RLQQEIEE 425

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  565 QLKDLKvkyegasaevgklRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLA 644
Cdd:TIGR02168  426 LLKKLE-------------EAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLD 492

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  645 LsipAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIR---QLKRELENVKAKLAQHVKPEEHEQVKSRLE-QKSGE 720
Cdd:TIGR02168  493 S---LERLQENLEGFSEGVKALLKNQSGLSGILGVLSELISvdeGYEAAIEAALGGRLQAVVVENLNAAKKAIAfLKQNE 569

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  721 LGKkiteLTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKK--SHDAIIDDLN-----RKLLD--- 790
Cdd:TIGR02168  570 LGR----VTFLPLDSIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSYllGGVLVVDDLDnalelAKKLRpgy 645

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  791 --VT--------------------QKYTEKKLEMEKLLLENDSLSKDVSRLETVFvppEKHEKEIIALKSNIVELKKQLS 848
Cdd:TIGR02168  646 riVTldgdlvrpggvitggsaktnSSILERRREIEELEEKIEELEEKIAELEKAL---AELRKELEELEEELEQLRKELE 722

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  849 ELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILK 928
Cdd:TIGR02168  723 ELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALR 802

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  929 RNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKY--- 1005
Cdd:TIGR02168  803 EALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLner 882

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1006 ----APIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDK-TVLIEKSHEMERA 1080
Cdd:TIGR02168  883 asleEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERLSEEySLTLEEAEALENK 962

                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034591230 1081 LSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEilavQNLLQKQHvplEQVEALKKSLNGTIENLKEELKS 1157
Cdd:TIGR02168  963 IEDDEEEARRRLKRLENKIKELGPVNLAAIEEYEELKER----YDFLTAQK---EDLTEAKETLEEAIEEIDREARE 1032
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 95-246 1.12e-13

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 76.06  E-value: 1.12e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230   95 VTSKGNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADCPSSIQLLC 174
Cdd:PLN03192   532 VASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILY 611

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034591230  175 dHGASVNAKDVDGRTpLVLATQMSRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLIKNGADI 246
Cdd:PLN03192   612 -HFASISDPHAAGDL-LCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADV 681
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
906-1400 2.21e-13

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 75.10  E-value: 2.21e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  906 VKKKFEDINQEFVKIKDKNEILKRNLENtqnqIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHA 985
Cdd:PRK03918   198 KEKELEEVLREINEISSELPELREELEK----LEKEVKELEELKEEIEELEKELESLEGSKRKLEEKIRELEERIEELKK 273

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  986 EIKAQKKELDTIQEcIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKkEIFTLQKDLR 1065
Cdd:PRK03918   274 EIEELEEKVKELKE-LKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKELEEKEERLE-ELKKKLKELE 351

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1066 DKTVLIEKSHE--------MERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQV 1137
Cdd:PRK03918   352 KRLEELEERHElyeeakakKEELERLKKRLTGLTPEKLEKELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEEL 431

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1138 EA-------------------LKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEK 1198
Cdd:PRK03918   432 KKakgkcpvcgrelteehrkeLLEEYTAELKRIEKELKEIEEKERKLRKELRELEKVLKKESELIKLKELAEQLKELEEK 511

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1199 EVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLEtrevvdlsKYKATKSDLETQISSLNEKLANLNRKYEEV- 1277
Cdd:PRK03918   512 LKKYNLEELEKKAEEYEKLKEKLIKLKGEIKSLKKELEKLE--------ELKKKLAELEKKLDELEEELAELLKELEELg 583

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1278 --CEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELL-----NDVER 1350
Cdd:PRK03918   584 feSVEELEERLKELEPFYNEYLELKDAEKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELEELEkkyseEEYEE 663

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1351 LKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEV 1400
Cdd:PRK03918   664 LREEYLELSRELAGLRAELEELEKRREEIKKTLEKLKEELEEREKAKKEL 713
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 502-1277 2.95e-13

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 75.10  E-value: 2.95e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  502 ERVKEDSDEQIKQL-------EDALK--DVQKRMYESEGKVkqmqtHFLALKEHLTSEAASGNHRltEELKDQLKDLKVK 572
Cdd:TIGR02169  187 ERLDLIIDEKRQQLerlrrerEKAERyqALLKEKREYEGYE-----LLKEKEALERQKEAIERQL--ASLEEELEKLTEE 259

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  573 YEGASAEVGKLRNQIKqnemivEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLA-LSIPAEK 651
Cdd:TIGR02169  260 ISELEKRLEEIEQLLE------ELNKKIKDLGEEEQLRVKEKIGELEAEIASLERSIAEKERELEDAEERLAkLEAEIDK 333

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  652 FENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVkpEEHEQVKSRLEQKSGELGKKITELTLK 731
Cdd:TIGR02169  334 LLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETR--DELKDYREKLEKLKREINELKRELDRL 411

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  732 NQTLQK-EIEKVYLDNKL--LKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLE 808
Cdd:TIGR02169  412 QEELQRlSEELADLNAAIagIEAKINELEEEKEDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQRE 491

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  809 NDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKC--------------------GEDQEKIHALTSEN 868
Cdd:TIGR02169  492 LAEAEAQARASEERVRGGRAVEEVLKASIQGVHGTVAQLGSVGERYataievaagnrlnnvvveddAVAKEAIELLKRRK 571

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  869 TN------LKKMMSNQYVPVKTHEE-------------------VKMTLNDTLA----KTNRELLD-------------- 905
Cdd:TIGR02169  572 AGratflpLNKMRDERRDLSILSEDgvigfavdlvefdpkyepaFKYVFGDTLVvediEAARRLMGkyrmvtlegelfek 651

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  906 --------VKKKFEDINQefVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQ 977
Cdd:TIGR02169  652 sgamtggsRAPRGGILFS--RSEPAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLE 729

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  978 EEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYsvSEEEVKKNKQENDKLKKEI 1057
Cdd:TIGR02169  730 QEEEKLKERLEELEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEEALNDLEARL--SHSRIPEIQAELSKLEEEV 807

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1058 FTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLsqkyTEVKNVKEKLVEENAKQTSEILAVqnlLQKQHVPLEQV 1137
Cdd:TIGR02169  808 SRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDL----KEQIKSIEKEIENLNGKKEELEEE---LEELEAALRDL 880

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1138 EALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSsvplaehlqiKEAFEKEVGIIKASLREKEEESQNK 1217
Cdd:TIGR02169  881 ESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAK----------LEALEEELSEIEDPKGEDEEIPEEE 950

                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1218 MEEvSKLQSEVQNTKQALKKLET----------REVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEV 1277
Cdd:TIGR02169  951 LSL-EDVQAELQRVEEEIRALEPvnmlaiqeyeEVLKRLDELKEKRAKLEEERKAILERIEEYEKKKREV 1019
PTZ00121 PTZ00121
MAEBL; Provisional
 646-1350 3.09e-13

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 75.18  E-value: 3.09e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  646 SIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKI 725
Cdd:PTZ00121  1075 SYKDFDFDAKEDNRADEATEEAFGKAEEAKKTETGKAEEARKAEEAKKKAEDARKAEEARKAEDARKAEEARKAEDAKRV 1154

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  726 TELTLKNQTLQKEIEKVYLDNKllKEQAHNLTIEMKNHYvPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKL 805
Cdd:PTZ00121  1155 EIARKAEDARKAEEARKAEDAK--KAEAARKAEEVRKAE-ELRKAEDARKAEAARKAEEERKAEEARKAEDAKKAEAVKK 1231

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  806 LLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNlkkmmsnqyvpvKTH 885
Cdd:PTZ00121  1232 AEEAKKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAK------------KAE 1299

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  886 EEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAeyislAEHEAKMSSLSQSMRKVQDS 965
Cdd:PTZ00121  1300 EKKKADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEA-----AADEAEAAEEKAEAAEKKKE 1374

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  966 NAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEK--ELKDQLSEQTQKYSVSEEEV 1043
Cdd:PTZ00121  1375 EAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKadEAKKKAEEAKKADEAKKKAE 1454

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1044 KKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERA---LSRKTDELNKQlKDLSQKYTEVKNVKEKLVEENAKQTSEI 1120
Cdd:PTZ00121  1455 EAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKaeeAKKKADEAKKA-AEAKKKADEAKKAEEAKKADEAKKAEEA 1533

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1121 LAVQNLLQKQHV----PLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAF 1196
Cdd:PTZ00121  1534 KKADEAKKAEEKkkadELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAK 1613

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1197 EKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEE 1276
Cdd:PTZ00121  1614 KAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEA 1693

                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034591230 1277 VCEEVLHAKKKEISAKDEKELLHfSIEQEIKDQKERCDKS--LTTITELQRRIQESAKQIEAKDNKITELLNDVER 1350
Cdd:PTZ00121  1694 LKKEAEEAKKAEELKKKEAEEKK-KAEELKKAEEENKIKAeeAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEK 1768
PTZ00121 PTZ00121
MAEBL; Provisional
 540-1337 3.20e-13

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 75.18  E-value: 3.20e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  540 FLALKEHLTSEAASGNHRLTEELKdQLKDLKVKYEGASAEVGKLRNQIKQNEmivEEFKRDEGKLIEENKRLQKELSMCE 619
Cdd:PTZ00121  1081 FDAKEDNRADEATEEAFGKAEEAK-KTETGKAEEARKAEEAKKKAEDARKAE---EARKAEDARKAEEARKAEDAKRVEI 1156

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  620 MEREKKGRKVTEMEG--QAKELSAklalsipAEKFENMKSSLSNEVNEKAKKLVEMER-EHEKSLSEIRQLKRELENVKA 696
Cdd:PTZ00121  1157 ARKAEDARKAEEARKaeDAKKAEA-------ARKAEEVRKAEELRKAEDARKAEAARKaEEERKAEEARKAEDAKKAEAV 1229

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  697 KLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEI--EKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMK 774
Cdd:PTZ00121  1230 KKAEEAKKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIkaEEARKADELKKAEEKKKADEAKKAEEKKKADEAKK 1309

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  775 KSHDAiiddlnRKLLDVTQKYTEKKLEMEKLLLENDSLSKdvsRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKC 854
Cdd:PTZ00121  1310 KAEEA------KKADEAKKKAEEAKKKADAAKKKAEEAKK---AAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKA 1380

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  855 GEDQEKIHALTSENTNLKKMMSNQyvpvKTHEEVKMTlndtlAKTNRELLDVKKKFEDinqefvkiKDKNEILKRNLENT 934
Cdd:PTZ00121  1381 DAAKKKAEEKKKADEAKKKAEEDK----KKADELKKA-----AAAKKKADEAKKKAEE--------KKKADEAKKKAEEA 1443

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  935 QnqiKAEYISLAEHEAKMSSlsqsmrkvqdsNAEILANYRKGQEEIVTlHAEIKAQKKELDTIQECIKVKYApivsfeec 1014
Cdd:PTZ00121  1444 K---KADEAKKKAEEAKKAE-----------EAKKKAEEAKKADEAKK-KAEEAKKADEAKKKAEEAKKKAD-------- 1500

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1015 ERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKd 1094
Cdd:PTZ00121  1501 EAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMA- 1579

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1095 lSQKYTEVKNVKEKLVEENAKQTSEILAVQ-NLLQKQHVPLEQVEALKKSlngtienlKEELKSMQRCYEKEQQTVTKLH 1173
Cdd:PTZ00121  1580 -LRKAEEAKKAEEARIEEVMKLYEEEKKMKaEEAKKAEEAKIKAEELKKA--------EEEKKKVEQLKKKEAEEKKKAE 1650

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1174 QLLENQKNSSVPlAEHLQIKEAFEKEvgiiKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATK 1253
Cdd:PTZ00121  1651 ELKKAEEENKIK-AAEEAKKAEEDKK----KAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAE 1725

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1254 SDLETQISSLNEKLANLNRKYEEvceevlhAKKKEisaKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQ 1333
Cdd:PTZ00121  1726 EENKIKAEEAKKEAEEDKKKAEE-------AKKDE---EEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRME 1795


                   ....
gi 1034591230 1334 IEAK 1337
Cdd:PTZ00121  1796 VDKK 1799
PHA03095 PHA03095
ankyrin-like protein; Provisional
 65-265 4.15e-13

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 73.52  E-value: 4.15e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230   65 GDVEKVTSILAKKGVNPGKLDVEGRSVFHVVTSKGNLECLNAILI-HGVDITTSDTAGRNALH--LAAKYGHALCLQKLL 141
Cdd:PHA03095    60 EKVKDIVRLLLEAGADVNAPERCGFTPLHLYLYNATTLDVIKLLIkAGADVNAKDKVGRTPLHvyLSGFNINPKVIRLLL 139

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  142 QYNCPTEHADLQGRTALH------DAamadCPSSIQLLCDHGASVNAKDVDGRTPL--VLATQMSRPTICQLLIDRGADV 213
Cdd:PHA03095   140 RKGADVNALDLYGMTPLAvllksrNA----NVELLRLLIDAGADVYAVDDRFRSLLhhHLQSFKPRARIVRELIRAGCDP 215

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1034591230  214 NSRDKQNRTALMLGCEYG-CRDA-VEVLIKNGADISLLDALGHDSSYYARIGDN 265
Cdd:PHA03095   216 AATDMLGNTPLHSMATGSsCKRSlVLPLLIAGISINARNRYGQTPLHYAAVFNN 269
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 571-1349 8.21e-13

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 73.56  E-value: 8.21e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  571 VKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKG----RKVTEMEGQAKELSAKLA-L 645
Cdd:TIGR02169  170 RKKEKALEELEEVEENIERLDLIIDEKRQQLERLRREREKAERYQALLKEKREYEGyellKEKEALERQKEAIERQLAsL 249

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  646 SIPAEKFENMKSSLSNEVNEKAKKLVEMERE-HEKSLSEIRQLKRELENVKAKLAQHV-KPEEHEQVKSRLEQKSGELGK 723
Cdd:TIGR02169  250 EEELEKLTEEISELEKRLEEIEQLLEELNKKiKDLGEEEQLRVKEKIGELEAEIASLErSIAEKERELEDAEERLAKLEA 329

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  724 KITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLK-VSEDMKKSHDAIiDDLNRKLLDVTQKYTEKKLEM 802
Cdd:TIGR02169  330 EIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEeVDKEFAETRDEL-KDYREKLEKLKREINELKREL 408

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  803 EKLLLENDSLSKDVSRletvfvppekHEKEIIALKSNIVELKKQLSELkkkcgedQEKIHALTSENTNLKKMMSNQYVPV 882
Cdd:TIGR02169  409 DRLQEELQRLSEELAD----------LNAAIAGIEAKINELEEEKEDK-------ALEIKKQEWKLEQLAADLSKYEQEL 471

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  883 KTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIkAEYISLAEHEAKMSSLSQSMR-- 960
Cdd:TIGR02169  472 YDLKEEYDRVEKELSKLQRELAEAEAQARASEERVRGGRAVEEVLKASIQGVHGTV-AQLGSVGERYATAIEVAAGNRln 550

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  961 -------KVQDSNAEILANYRKGQEEIVTLHaEIKAQKKELDTIQECIKVKYApiVSFEECERKFkatekelkdqlsEQT 1033
Cdd:TIGR02169  551 nvvveddAVAKEAIELLKRRKAGRATFLPLN-KMRDERRDLSILSEDGVIGFA--VDLVEFDPKY------------EPA 615

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1034 QKYSVSEEEVKKNKQENDKL--KKEIFTLQKDLRDKTVLIEKSH--------------EMERALSRKTDELNKQLKDLSQ 1097
Cdd:TIGR02169  616 FKYVFGDTLVVEDIEAARRLmgKYRMVTLEGELFEKSGAMTGGSraprggilfsrsepAELQRLRERLEGLKRELSSLQS 695

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1098 KYTEVKN-VKEKL--VEENAKQTSEILAVQNLLQKQHVP----LEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVT 1170
Cdd:TIGR02169  696 ELRRIENrLDELSqeLSDASRKIGEIEKEIEQLEQEEEKlkerLEELEEDLSSLEQEIENVKSELKELEARIEELEEDLH 775

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1171 KLHQLLEN--QKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREvvdlSK 1248
Cdd:TIGR02169  776 KLEEALNDleARLSHSRIPEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQI----KS 851

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1249 YKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKEllhfSIEQEIKDQKERCDKSLTTITELQRRIQ 1328
Cdd:TIGR02169  852 IEKEIENLNGKKEELEEELEELEAALRDLESRLGDLKKERDELEAQLR----ELERKIEELEAQIEKKRKRLSELKAKLE 927

                          810       820
                   ....*....|....*....|.
gi 1034591230 1329 ESAKQIEAKDNKITELLNDVE 1349
Cdd:TIGR02169  928 ALEEELSEIEDPKGEDEEIPE 948
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 328-1160 1.03e-12

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 73.17  E-value: 1.03e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  328 ERLRKIQQEQRilldkvnglQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIEALknrfkyfESDHLGSGSHF 407
Cdd:TIGR02168  213 ERYKELKAELR---------ELELALLVLRLEELREELEELQEELKEAEEELEELTAELQEL-------EEKLEELRLEV 276

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  408 SNRKEDMLLKQGQMYMADSQCT--SPGIPAHMQSRSMLR--PLELSLPSQTSYSENEILKKELEAMRTFCESAKQDRLKL 483
Cdd:TIGR02168  277 SELEEEIEELQKELYALANEISrlEQQKQILRERLANLErqLEELEAQLEELESKLDELAEELAELEEKLEELKEELESL 356

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  484 QNELAHKVAECKALalecERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTseaasgnhRLTEELK 563
Cdd:TIGR02168  357 EAELEELEAELEEL----ESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRE--------RLQQEIE 424

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  564 DQLKDLKvkyegasaevgklRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKL 643
Cdd:TIGR02168  425 ELLKKLE-------------EAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARL 491

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  644 ALsipAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIR---QLKRELENVKAKLAQHVKPEEHEQVKSRLE-QKSG 719
Cdd:TIGR02168  492 DS---LERLQENLEGFSEGVKALLKNQSGLSGILGVLSELISvdeGYEAAIEAALGGRLQAVVVENLNAAKKAIAfLKQN 568

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  720 ELGKkiteLTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKK--SHDAIIDDLnrklldvtqkytE 797
Cdd:TIGR02168  569 ELGR----VTFLPLDSIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSYllGGVLVVDDL------------D 632

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  798 KKLEMEKLLLENDSL-SKDVSRLETVFVPPEKHEKEiialKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMS 876
Cdd:TIGR02168  633 NALELAKKLRPGYRIvTLDGDLVRPGGVITGGSAKT----NSSILERRREIEELEEKIEELEEKIAELEKALAELRKELE 708

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  877 NQyvpvkthEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKA-------EYISLAEHE 949
Cdd:TIGR02168  709 EL-------EEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEEleerleeAEEELAEAE 781

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  950 AKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQL 1029
Cdd:TIGR02168  782 AEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEI 861

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1030 SEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVK----NV 1105
Cdd:TIGR02168  862 EELEELIEELESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEvridNL 941

                          810       820       830       840       850
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1034591230 1106 KEKLVEEnakqtseilavqnllqkQHVPLEQVEALKKSLNGTIENLKEELKSMQR 1160
Cdd:TIGR02168  942 QERLSEE-----------------YSLTLEEAEALENKIEDDEEEARRRLKRLEN 979
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 68-255 2.32e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 70.76  E-value: 2.32e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230   68 EKVTSILaKKGVNPGKLDVEGRSVFHVVTSKGNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPT 147
Cdd:PHA02874   105 DMIKTIL-DCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYA 183

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  148 EHADLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRPTIcQLLIDrGADVNSRDKQNRTALMLG 227
Cdd:PHA02874   184 NVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNRSAI-ELLIN-NASINDQDIDGSTPLHHA 261

                          170       180
                   ....*....|....*....|....*....
gi 1034591230  228 CEYGC-RDAVEVLIKNGADISLLDALGHD 255
Cdd:PHA02874   262 INPPCdIDIIDILLYHKADISIKDNKGEN 290
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
480-1024 2.45e-12

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 72.02  E-value: 2.45e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  480 RLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEaasgnhRLT 559
Cdd:PRK03918   229 EVKELEELKEEIEELEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKELKELKEKAEEYIKLS------EFY 302

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  560 EELKDQLKDLKVKYEGASAEVGKLRNQIKQnemiVEEFKRDEGKLIEENKRLQKELSMCEmEREKKGRKVTEMEGQAKEL 639
Cdd:PRK03918   303 EEYLDELREIEKRLSRLEEEINGIEERIKE----LEEKEERLEELKKKLKELEKRLEELE-ERHELYEEAKAKKEELERL 377

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  640 SAKLAlSIPAEKFENMKSSLSN---EVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAK---LAQHVKPEEHEQVKSR 713
Cdd:PRK03918   378 KKRLT-GLTPEKLEKELEELEKakeEIEEEISKITARIGELKKEIKELKKAIEELKKAKGKcpvCGRELTEEHRKELLEE 456

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  714 LEQKSGELGKKITELTLKNQTLQKEIEKVylDNKLLKEQAhnlTIEMKNHYVPLKVSEDMKKSHDAiiddlnrklldvtQ 793
Cdd:PRK03918   457 YTAELKRIEKELKEIEEKERKLRKELREL--EKVLKKESE---LIKLKELAEQLKELEEKLKKYNL-------------E 518

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  794 KYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQ-EKIHALTSENTNLK 872
Cdd:PRK03918   519 ELEKKAEEYEKLKEKLIKLKGEIKSLKKELEKLEELKKKLAELEKKLDELEEELAELLKELEELGfESVEELEERLKELE 598

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  873 KMMsNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNL-ENTQNQIKAEYISLAEHEAK 951
Cdd:PRK03918   599 PFY-NEYLELKDAEKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELEELEKKYsEEEYEELREEYLELSRELAG 677

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034591230  952 MSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQEcikvkyapivsFEECERKFKATEKE 1024
Cdd:PRK03918   678 LRAELEELEKRREEIKKTLEKLKEELEEREKAKKELEKLEKALERVEE-----------LREKVKKYKALLKE 739
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 510-1306 6.54e-12

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 70.85  E-value: 6.54e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  510 EQIKQLEDALKDVQKRMYESegKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQ 589
Cdd:TIGR01612  974 DKINELDKAFKDASLNDYEA--KNNELIKYFNDLKANLGKNKENMLYHQFDEKEKATNDIEQKIEDANKNIPNIEIAIHT 1051

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  590 NEM-IVEEFKRDEGKLIEE-NKRLQKE--LSMCEMEREKKGRKVTEMEGQAKELSAKLALSIpaEKFENMKSSLSNEVNE 665
Cdd:TIGR01612 1052 SIYnIIDEIEKEIGKNIELlNKEILEEaeINITNFNEIKEKLKHYNFDDFGKEENIKYADEI--NKIKDDIKNLDQKIDH 1129

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  666 KAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQ----VKSRLEQKSG---ELGKKITELTL--KNQTLQ 736
Cdd:TIGR01612 1130 HIKALEEIKKKSENYIDEIKAQINDLEDVADKAISNDDPEEIEKkienIVTKIDKKKNiydEIKKLLNEIAEieKDKTSL 1209

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  737 KEIEKVYLD-----NKLLKEQAHnltiEMKnhyvplKVSEDMKKSHDAIIDDLNrkllDVTQKYTEKKLEMEKLLLENds 811
Cdd:TIGR01612 1210 EEVKGINLSygknlGKLFLEKID----EEK------KKSEHMIKAMEAYIEDLD----EIKEKSPEIENEMGIEMDIK-- 1273

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  812 lskdvSRLETVFVPPEKHEKEIIALKSNivelKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMT 891
Cdd:TIGR01612 1274 -----AEMETFNISHDDDKDHHIISKKH----DENISDIREKSLKIIEDFSEESDINDIKKELQKNLLDAQKHNSDINLY 1344

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  892 LNDTLAKTN-RELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKA--EYISLAEHEAKMSSLSQSmrkvQDSNaE 968
Cdd:TIGR01612 1345 LNEIANIYNiLKLNKIKKIIDEVKEYTKEIEENNKNIKDELDKSEKLIKKikDDINLEECKSKIESTLDD----KDID-E 1419

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  969 ILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIvsfEECERKFKATEKELKD-----------QLSEQTQKYS 1037
Cdd:TIGR01612 1420 CIKKIKELKNHILSEESNIDTYFKNADENNENVLLLFKNI---EMADNKSQHILKIKKDnatndhdfninELKEHIDKSK 1496

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1038 VSEEEVKKNKQENDKlKKEIFTLQKdlRDKTVLIEKSHEMEralsrKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQT 1117
Cdd:TIGR01612 1497 GCKDEADKNAKAIEK-NKELFEQYK--KDVTELLNKYSALA-----IKNKFAKTKKDSEIIIKEIKDAHKKFILEAEKSE 1568

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1118 SEIlavqNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQrcyekeqqtvTKLHQLLENQKNSSVPLAEhlqiKEAFE 1197
Cdd:TIGR01612 1569 QKI----KEIKKEKFRIEDDAAKNDKSNKAAIDIQLSLENFE----------NKFLKISDIKKKINDCLKE----TESIE 1630

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1198 KEVGIIkaSLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETRevvdlskyKATKSDLETQISSLNEKLANLNRKYE-- 1275
Cdd:TIGR01612 1631 KKISSF--SIDSQDTELKENGDNLNSLQEFLESLKDQKKNIEDK--------KKELDELDSEIEKIEIDVDQHKKNYEig 1700

                          810       820       830
                   ....*....|....*....|....*....|...
gi 1034591230 1276 --EVCEEVLHAKKKEISAKdeKELLHFSIEQEI 1306
Cdd:TIGR01612 1701 iiEKIKEIAIANKEEIESI--KELIEPTIENLI 1731
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 674-1353 6.63e-12

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 70.43  E-value: 6.63e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  674 EREHEKSLSEIRQLKRELENVKAKLAQHVKPE-EHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQ 752
Cdd:TIGR04523   32 DTEEKQLEKKLKTIKNELKNKEKELKNLDKNLnKDEEKINNSNNKIKILEQQIKDLNDKLKKNKDKINKLNSDLSKINSE 111

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  753 AHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLldvtqkyTEKKLEMEKLLLENDSLSKDVSRLETVFvppEKHEKE 832
Cdd:TIGR04523  112 IKNDKEQKNKLEVELNKLEKQKKENKKNIDKFLTEI-------KKKEKELEKLNNKYNDLKKQKEELENEL---NLLEKE 181

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  833 IIALKSNIVELKKQLSELKKKCGEDQEKIH---ALTSENTNLKKMMSNqyvpvktheevkmtLNDTLAKTNRELLDVKKK 909
Cdd:TIGR04523  182 KLNIQKNIDKIKNKLLKLELLLSNLKKKIQknkSLESQISELKKQNNQ--------------LKDNIEKKQQEINEKTTE 247

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  910 FEDINQEFVKIKDKNEILKRNLENTQNQIKaeyislaEHEAKMSSLSQsmrKVQDSNAEILA-NYRKGQEEIVTLHAEIK 988
Cdd:TIGR04523  248 ISNTQTQLNQLKDEQNKIKKQLSEKQKELE-------QNNKKIKELEK---QLNQLKSEISDlNNQKEQDWNKELKSELK 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  989 AQKKELDTIQECIKVKYAPIVSFEECERKFKATEK-------ELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQ 1061
Cdd:TIGR04523  318 NQEKKLEEIQNQISQNNKIISQLNEQISQLKKELTnsesensEKQRELEEKQNEIEKLKKENQSYKQEIKNLESQINDLE 397

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1062 KDLRDKTVLiekshemeralsrkTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEIlavQNLLQKQHVpleqVEALK 1141
Cdd:TIGR04523  398 SKIQNQEKL--------------NQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSEI---KDLTNQDSV----KELII 456

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1142 KSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNkmeEV 1221
Cdd:TIGR04523  457 KNLDNTRESLETQLKVLSRSINKIKQNLEQKQKELKSKEKELKKLNEEKKELEEKVKDLTKKISSLKEKIEKLES---EK 533

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1222 SKLQSEVQNTKQALKKLETRevvdlskykATKSDLETQISSLNEKLanlnrkyeevcEEVLHAKKKEISAKDEKELLHFS 1301
Cdd:TIGR04523  534 KEKESKISDLEDELNKDDFE---------LKKENLEKEIDEKNKEI-----------EELKQTQKSLKKKQEEKQELIDQ 593

                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1034591230 1302 IEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQ 1353
Cdd:TIGR04523  594 KEKEKKDLIKEIEEKEKKISSLEKELEKAKKENEKLSSIIKNIKSKKNKLKQ 645
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 7-290 1.25e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 69.32  E-value: 1.25e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230    7 IILNVSCISCVLGRFYNSALLMKLAQKGEGNLECNWKISDHAADWNKyddrLMKAAERGDVEKVTSILAKKGVNPGKLDV 86
Cdd:PHA02876   101 IILDIKYASIILNKHKLDEACIHILKEAISGNDIHYDKINESIEYMK----LIKERIQQDELLIAEMLLEGGADVNAKDI 176

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230   87 EGRSVFHVVTSKGNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDaamADC 166
Cdd:PHA02876   177 YCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSNINKNDLSLLKAIRN---EDL 253

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  167 PSSIqLLCDHGASVNAKDVDGRTPLVLATQMsrPTICQL---LIDRGADVNSRDKQNRTALMLGCEYGC-RDAVEVLIKN 242
Cdd:PHA02876   254 ETSL-LLYDAGFSVNSIDDCKNTPLHHASQA--PSLSRLvpkLLERGADVNAKNIKGETPLYLMAKNGYdTENIRTLIML 330

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*....
gi 1034591230  243 GADISLLDALGHDSSYYARIGD-NLDILTLLKTASENTNkGRELWKKGP 290
Cdd:PHA02876   331 GADVNAADRLYITPLHQASTLDrNKDIVITLLELGANVN-ARDYCDKTP 378
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 462-1231 3.09e-11

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 68.22  E-value: 3.09e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  462 LKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLedalkdvQKRMYESEGKVKQMQTHFL 541
Cdd:pfam15921  122 MQMERDAMADIRRRESQSQEDLRNQLQNTVHELEAAKCLKEDMLEDSNTQIEQL-------RKMMLSHEGVLQEIRSILV 194

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  542 ALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIE-----ENKRLQKELS 616
Cdd:pfam15921  195 DFEEASGKKIYEHDSMSTMHFRSLGSAISKILRELDTEISYLKGRIFPVEDQLEALKSESQNKIElllqqHQDRIEQLIS 274

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  617 MCEMEREKKGRKVTEMEGQAKELSAKLalsipaekfENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKA 696
Cdd:pfam15921  275 EHEVEITGLTEKASSARSQANSIQSQL---------EIIQEQARNQNSMYMRQLSDLESTVSQLRSELREAKRMYEDKIE 345

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  697 KLAQHVKPEEHEQVKSRLE-----QKSGELGKKITELTLKNQTLQKEIEkvyldnkLLKEQAHNLTiemknhyvplkvse 771
Cdd:pfam15921  346 ELEKQLVLANSELTEARTErdqfsQESGNLDDQLQKLLADLHKREKELS-------LEKEQNKRLW-------------- 404

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  772 DMKKSHDAIIDDLNRKLldvtqkytekklemeklllenDSLSKDVSRLETVfvppekhekeIIALKSNIV-ELKKQLSEL 850
Cdd:pfam15921  405 DRDTGNSITIDHLRREL---------------------DDRNMEVQRLEAL----------LKAMKSECQgQMERQMAAI 453

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  851 KKKcGEDQEKIHALTSENTNLKKMMSnqyvpvKTHEEV---KMTLND---TLAKTNRELLDVKKKFEDINQEFVKIKDKN 924
Cdd:pfam15921  454 QGK-NESLEKVSSLTAQLESTKEMLR------KVVEELtakKMTLESserTVSDLTASLQEKERAIEATNAEITKLRSRV 526

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  925 EILKRNLENTQNQikAEYISLAEHEAKMSSLSQSMRkvqDSNAEILANYRKGQEEIVTLHAEIK-AQKKELDTIQECIKV 1003
Cdd:pfam15921  527 DLKLQELQHLKNE--GDHLRNVQTECEALKLQMAEK---DKVIEILRQQIENMTQLVGQHGRTAgAMQVEKAQLEKEIND 601

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1004 KYAPIVSFEECERKFKATEKELKDQLS----EQTQKYSVSEEE---VKKNKQENDKLKKEIFTLQKDLRDKTVLIE---- 1072
Cdd:pfam15921  602 RRLELQEFKILKDKKDAKIRELEARVSdlelEKVKLVNAGSERlraVKDIKQERDQLLNEVKTSRNELNSLSEDYEvlkr 681

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1073 ----KSHEMERAlsrkTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHvplEQVEALKKSlngtI 1148
Cdd:pfam15921  682 nfrnKSEEMETT----TNKLKMQLKSAQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKR---GQIDALQSK----I 750

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1149 ENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEK---------EVGIIKASLREKEEESQNKME 1219
Cdd:pfam15921  751 QFLEEAMTNANKEKHFLKEEKNKLSQELSTVATEKNKMAGELEVLRSQERrlkekvanmEVALDKASLQFAECQDIIQRQ 830

                          810
                   ....*....|..
gi 1034591230 1220 EVSKLQSEVQNT 1231
Cdd:pfam15921  831 EQESVRLKLQHT 842
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 66-214 4.62e-11

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 66.61  E-value: 4.62e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230   66 DVEKVTSILAKKGVNPGKLDVEGRSVFHV--VTSKGNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHA------LCL 137
Cdd:PHA03100    84 DVKEIVKLLLEYGANVNAPDNNGITPLLYaiSKKSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIdlkilkLLI 163

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  138 QK------------LLQYNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQL 205
Cdd:PHA03100   164 DKgvdinaknrvnyLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKL 243


                   ....*....
gi 1034591230  206 LIDRGADVN 214
Cdd:PHA03100   244 LLNNGPSIK 252
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 502-1339 6.90e-11

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 67.45  E-value: 6.90e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  502 ERVKEDSDEQIKqledalkDVQKRMYES------------------EGKVKQMQTHFLALKEHLTSEAASgnhrlTEELK 563
Cdd:pfam15921   77 ERVLEEYSHQVK-------DLQRRLNESnelhekqkfylrqsvidlQTKLQEMQMERDAMADIRRRESQS-----QEDLR 144

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  564 DQLKDLKVKYEGA-SAEVGKLRNQIKQNEMIVEEFKRDEGKlieenkrLQKELSMCEMEREKKGRKVTEMEgqakelsak 642
Cdd:pfam15921  145 NQLQNTVHELEAAkCLKEDMLEDSNTQIEQLRKMMLSHEGV-------LQEIRSILVDFEEASGKKIYEHD--------- 208

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  643 lalSIPAEKFENMKSSLSnevnekaKKLVEMEREHEKSLSEIRQLKRELENVKAKlAQHVKPEEHEQVKSRLEQKSGELG 722
Cdd:pfam15921  209 ---SMSTMHFRSLGSAIS-------KILRELDTEISYLKGRIFPVEDQLEALKSE-SQNKIELLLQQHQDRIEQLISEHE 277

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  723 KKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVS--------EDMKKSHDAIIDDLNRKLLDVTQK 794
Cdd:pfam15921  278 VEITGLTEKASSARSQANSIQSQLEIIQEQARNQNSMYMRQLSDLESTvsqlrselREAKRMYEDKIEELEKQLVLANSE 357

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  795 YTEKKLEMEKLLLENDSLSkdvSRLETVFVPPEKHEKEIialksnivelkkQLSELKKKCGEDQEKIHALTSEntNLKKM 874
Cdd:pfam15921  358 LTEARTERDQFSQESGNLD---DQLQKLLADLHKREKEL------------SLEKEQNKRLWDRDTGNSITID--HLRRE 420

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  875 MSNQYVPVKTHEEVKMTL-NDTLAKTNRELLDVKKK---FEDINQEFVKIKDKNEILKRNLEntqnQIKAEYISLAEHEA 950
Cdd:pfam15921  421 LDDRNMEVQRLEALLKAMkSECQGQMERQMAAIQGKnesLEKVSSLTAQLESTKEMLRKVVE----ELTAKKMTLESSER 496

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  951 KMSSLSQSM----RKVQDSNAEIlanyRKGQEEIVTLHAEIKAQKKELDTIQECIKvkyapivsfeECER-KFKATEKE- 1024
Cdd:pfam15921  497 TVSDLTASLqekeRAIEATNAEI----TKLRSRVDLKLQELQHLKNEGDHLRNVQT----------ECEAlKLQMAEKDk 562

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1025 ----LKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDL----S 1096
Cdd:pfam15921  563 vieiLRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEINDRRLELQEFKILKDKKDAKIRELEARVSDLELEKVKLvnagS 642

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1097 QKYTEVKNVKE---KLVEENAKQTSEIlavQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKlh 1173
Cdd:pfam15921  643 ERLRAVKDIKQerdQLLNEVKTSRNEL---NSLSEDYEVLKRNFRNKSEEMETTTNKLKMQLKSAQSELEQTRNTLKS-- 717

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1174 qlLENQKNSSVPLAEHLQIK-EAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREvvdlSKYKAT 1252
Cdd:pfam15921  718 --MEGSDGHAMKVAMGMQKQiTAKRGQIDALQSKIQFLEEAMTNANKEKHFLKEEKNKLSQELSTVATEK----NKMAGE 791

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1253 KSDLETQISSLNEKLANLNRKYEEVCEEVlhAKKKEISAKDEKELLHFSIEQEIkDQKERCDKSLTTITELQRRIQESAK 1332
Cdd:pfam15921  792 LEVLRSQERRLKEKVANMEVALDKASLQF--AECQDIIQRQEQESVRLKLQHTL-DVKELQGPGYTSNSSMKPRLLQPAS 868


                   ....*..
gi 1034591230 1333 QIEAKDN 1339
Cdd:pfam15921  869 FTRTHSN 875
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 37-256 7.89e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 66.63  E-value: 7.89e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230   37 NLECNWKISDHAADWNKYDD----RLMKAAERGDVEKVTSILAKKGVNPGKLDVEGRSVFHVVTSKG-NLECLNAILIHG 111
Cdd:PHA02876   252 DLETSLLLYDAGFSVNSIDDckntPLHHASQAPSLSRLVPKLLERGADVNAKNIKGETPLYLMAKNGyDTENIRTLIMLG 331

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  112 VDITTSDTAGRNALHLAAKYG-HALCLQKLLQYNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDVDGRTP 190
Cdd:PHA02876   332 ADVNAADRLYITPLHQASTLDrNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTA 411

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034591230  191 LVLATQMSRP-TICQLLIDRGADVNSRDKQNRTALMLGCEYGCR-DAVEVLIKNGADIS---------LLDALGHDS 256
Cdd:PHA02876   412 LHFALCGTNPyMSVKTLIDRGANVNSKNKDLSTPLHYACKKNCKlDVIEMLLDNGADVNainiqnqypLLIALEYHG 488
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 509-1322 1.49e-10

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 65.81  E-value: 1.49e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  509 DEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSeaasgnhrlteeLKDQLKDLKvkyegasAEVGKLRNQIK 588
Cdd:TIGR04523   32 DTEEKQLEKKLKTIKNELKNKEKELKNLDKNLNKDEEKINN------------SNNKIKILE-------QQIKDLNDKLK 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  589 QNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLalsipaEKFENMKSSLSNEVNEKAK 668
Cdd:TIGR04523   93 KNKDKINKLNSDLSKINSEIKNDKEQKNKLEVELNKLEKQKKENKKNIDKFLTEI------KKKEKELEKLNNKYNDLKK 166

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  669 KLVEMEREHEKSLSEIRQLKRELENVKAKLAqhvKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKvyldnkl 748
Cdd:TIGR04523  167 QKEELENELNLLEKEKLNIQKNIDKIKNKLL---KLELLLSNLKKKIQKNKSLESQISELKKQNNQLKDNIEK------- 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  749 LKEQAHNLTIEMKNHYVPLKvseDMKKSHDAIIDDLNRKLLDVTQkyTEKKLemeklllenDSLSKDVSRLETVF--VPP 826
Cdd:TIGR04523  237 KQQEINEKTTEISNTQTQLN---QLKDEQNKIKKQLSEKQKELEQ--NNKKI---------KELEKQLNQLKSEIsdLNN 302

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  827 EKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNqyvpvktheevkmtLNDTLAKTNRELLDV 906
Cdd:TIGR04523  303 QKEQDWNKELKSELKNQEKKLEEIQNQISQNNKIISQLNEQISQLKKELTN--------------SESENSEKQRELEEK 368

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  907 KKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQsmrkvqdsnaeilaNYRKGQEEIVTLHAE 986
Cdd:TIGR04523  369 QNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQIKKLQQ--------------EKELLEKEIERLKET 434

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  987 IKAQKKELDTIQECIKVKyapivsfeecerkfKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLrd 1066
Cdd:TIGR04523  435 IIKNNSEIKDLTNQDSVK--------------ELIIKNLDNTRESLETQLKVLSRSINKIKQNLEQKQKELKSKEKEL-- 498

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1067 ktvliekshemeRALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPL--EQVEALKKSL 1144
Cdd:TIGR04523  499 ------------KKLNEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEKESKISDLEDELNKDDFELkkENLEKEIDEK 566

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1145 NGTIENLKEELKSMQRCYEKEQQtvtKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKL 1224
Cdd:TIGR04523  567 NKEIEELKQTQKSLKKKQEEKQE---LIDQKEKEKKDLIKEIEEKEKKISSLEKELEKAKKENEKLSSIIKNIKSKKNKL 643

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1225 QSEVQNTKQALKKLetrevvdlskyKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELL------ 1298
Cdd:TIGR04523  644 KQEVKQIKETIKEI-----------RNKWPEIIKKIKESKTKIDDIIELMKDWLKELSLHYKKYITRMIRIKDLpkleek 712

                          810       820
                   ....*....|....*....|....
gi 1034591230 1299 HFSIEQEIKDQKErCDKSLTTITE 1322
Cdd:TIGR04523  713 YKEIEKELKKLDE-FSKELENIIK 735
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 38-281 1.73e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 64.98  E-value: 1.73e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230   38 LECNWKISDHAADWNKYddrLMKAAERGDVEKVTSILaKKGVNPGKLDVEGRSVFHVVTSKGNLECLNAILIHGVDITTS 117
Cdd:PHA02874   111 LDCGIDVNIKDAELKTF---LHYAIKKGDLESIKMLF-EYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVK 186

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  118 DTAGRNALHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADcPSSIQLLCDHgASVNAKDVDGRTPLVLATQM 197
Cdd:PHA02874   187 DNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHN-RSAIELLINN-ASINDQDIDGSTPLHHAINP 264

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  198 S-RPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAV-------EVLIKNGADISLLDALGHDSsyyarIGDNLDIL 269
Cdd:PHA02874   265 PcDIDIIDILLYHKADISIKDNKGENPIDTAFKYINKDPVikdiianAVLIKEADKLKDSDFLEHIE-----IKDNKEFS 339

                          250
                   ....*....|..
gi 1034591230  270 TLLKTASENTNK 281
Cdd:PHA02874   340 DFIKECNEEIED 351
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 650-1396 1.90e-10

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 65.91  E-value: 1.90e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  650 EKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQlkrELENVKAKLAQHVKPEEHEQVKSRLEQKSGElgkkitelT 729
Cdd:pfam15921   74 EHIERVLEEYSHQVKDLQRRLNESNELHEKQKFYLRQ---SVIDLQTKLQEMQMERDAMADIRRRESQSQE--------D 142

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  730 LKNQtLQKEIEKVYLdNKLLKEQAhnltieMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKklemeklLLEN 809
Cdd:pfam15921  143 LRNQ-LQNTVHELEA-AKCLKEDM------LEDSNTQIEQLRKMMLSHEGVLQEIRSILVDFEEASGKK-------IYEH 207

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  810 DSLSKdvsrletvfvppeKHEKEIIALKSNIV-ELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQyvpvktHEEv 888
Cdd:pfam15921  208 DSMST-------------MHFRSLGSAISKILrELDTEISYLKGRIFPVEDQLEALKSESQNKIELLLQQ------HQD- 267

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  889 kmTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKrnlENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAE 968
Cdd:pfam15921  268 --RIEQLISEHEVEITGLTEKASSARSQANSIQSQLEIIQ---EQARNQNSMYMRQLSDLESTVSQLRSELREAKRMYED 342

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  969 ILANYRKgqeEIVTLHAEIKAQKKELDtiqecikvkyapivsfeecerKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQ 1048
Cdd:pfam15921  343 KIEELEK---QLVLANSELTEARTERD---------------------QFSQESGNLDDQLQKLLADLHKREKELSLEKE 398

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1049 ENDKL-------KKEIFTLQKDLRDKTVLIEKsheMERALSRKTDELNKQLKdlsQKYTEVKNVKEKLvEENAKQTSEIL 1121
Cdd:pfam15921  399 QNKRLwdrdtgnSITIDHLRRELDDRNMEVQR---LEALLKAMKSECQGQME---RQMAAIQGKNESL-EKVSSLTAQLE 471

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1122 AVQNLLQKQhvpLEQVEALKKSLNG---TIENLKEELKSMQRCYEKEQQTVTKLH-------QLLENQKNSsvplAEHLQ 1191
Cdd:pfam15921  472 STKEMLRKV---VEELTAKKMTLESserTVSDLTASLQEKERAIEATNAEITKLRsrvdlklQELQHLKNE----GDHLR 544

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1192 IKEAfekEVGIIKASLREKE---EESQNKMEEVSKLQSE-------VQNTKQALKKLETREVVDLSKYKATKSDLETQIS 1261
Cdd:pfam15921  545 NVQT---ECEALKLQMAEKDkviEILRQQIENMTQLVGQhgrtagaMQVEKAQLEKEINDRRLELQEFKILKDKKDAKIR 621

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1262 SLNEKLANLNRKyeevceevlhaKKKEISAKDEKELLHFSIEQE---IKDQKERCDKSLTTITE----LQRRIQESAKQI 1334
Cdd:pfam15921  622 ELEARVSDLELE-----------KVKLVNAGSERLRAVKDIKQErdqLLNEVKTSRNELNSLSEdyevLKRNFRNKSEEM 690

                          730       740       750       760       770       780       790
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034591230 1335 EAKDNKITELLNDVE-RLKQALNGLSQLTYTSGNPTK----RQSQL------IDTLQHQVKSLEQQLADADRQ 1396
Cdd:pfam15921  691 ETTTNKLKMQLKSAQsELEQTRNTLKSMEGSDGHAMKvamgMQKQItakrgqIDALQSKIQFLEEAMTNANKE 763
PHA03095 PHA03095
ankyrin-like protein; Provisional
 139-254 2.55e-10

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 64.66  E-value: 2.55e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  139 KLLQYNCPTEHADLQGRTALH---DAAMADCPSSIQLLCDHGASVNAKDVDGRTPL-VLATQMSRPTICQLLIDRGADVN 214
Cdd:PHA03095    32 RLLAAGADVNFRGEYGKTPLHlylHYSSEKVKDIVRLLLEAGADVNAPERCGFTPLhLYLYNATTLDVIKLLIKAGADVN 111

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1034591230  215 SRDKQNRTALMLGCEYGCRDA--VEVLIKNGADISLLDALGH 254
Cdd:PHA03095   112 AKDKVGRTPLHVYLSGFNINPkvIRLLLRKGADVNALDLYGM 153
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 73-249 2.58e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 64.24  E-value: 2.58e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230   73 ILAKKGVNPGKLDVEGRSVFHVVTSKGNLECLNAILIHGV---DITTSDtaGRNALHLAAKYGHALCLQKLLQYNCPTEH 149
Cdd:PHA02875    53 LLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKfadDVFYKD--GMTPLHLATILKKLDIMKLLIARGADPDI 130

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  150 ADLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTALM-LGC 228
Cdd:PHA02875   131 PNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCVAALcYAI 210

                          170       180
                   ....*....|....*....|.
gi 1034591230  229 EYGCRDAVEVLIKNGADISLL 249
Cdd:PHA02875   211 ENNKIDIVRLFIKRGADCNIM 231
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 978-1388 3.49e-10

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 64.66  E-value: 3.49e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  978 EEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKY-------SVSEEEVKKNKQEN 1050
Cdd:TIGR04523   40 KKLKTIKNELKNKEKELKNLDKNLNKDEEKINNSNNKIKILEQQIKDLNDKLKKNKDKInklnsdlSKINSEIKNDKEQK 119

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1051 DKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQ 1130
Cdd:TIGR04523  120 NKLEVELNKLEKQKKENKKNIDKFLTEIKKKEKELEKLNNKYNDLKKQKEELENELNLLEKEKLNIQKNIDKIKNKLLKL 199

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1131 HVPLEQVEALK---KSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNssvplaEHLQIKEAFEKevgiIKASL 1207
Cdd:TIGR04523  200 ELLLSNLKKKIqknKSLESQISELKKQNNQLKDNIEKKQQEINEKTTEISNTQT------QLNQLKDEQNK----IKKQL 269

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1208 REKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKY--------KATKSDLETQISSLNEKLANLNRKYEEVCE 1279
Cdd:TIGR04523  270 SEKQKELEQNNKKIKELEKQLNQLKSEISDLNNQKEQDWNKElkselknqEKKLEEIQNQISQNNKIISQLNEQISQLKK 349

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1280 EVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSL---TTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALN 1356
Cdd:TIGR04523  350 ELTNSESENSEKQRELEEKQNEIEKLKKENQSYKQEIKnleSQINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIE 429

                          410       420       430
                   ....*....|....*....|....*....|..
gi 1034591230 1357 GLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQ 1388
Cdd:TIGR04523  430 RLKETIIKNNSEIKDLTNQDSVKELIIKNLDN 461
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 799-1390 3.88e-10

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 64.75  E-value: 3.88e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  799 KLEMEKLLLENDSLSKDVSRleTVFVPPEKHEKEIIALKSNIVELKKQLSELK-------------KKCGED-----QEK 860
Cdd:pfam15921   73 KEHIERVLEEYSHQVKDLQR--RLNESNELHEKQKFYLRQSVIDLQTKLQEMQmerdamadirrreSQSQEDlrnqlQNT 150

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  861 IHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDV-----KKKFEDINQEFVKIKDKNEILKRNLENTQ 935
Cdd:pfam15921  151 VHELEAAKCLKEDMLEDSNTQIEQLRKMMLSHEGVLQEIRSILVDFeeasgKKIYEHDSMSTMHFRSLGSAISKILRELD 230

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  936 NQI---KAEYISLAEHEAKMSSLSQS-----MRKVQDSNAEILANYrkgQEEIVTLHAEIKAQKKELDTIQ---ECIKVK 1004
Cdd:pfam15921  231 TEIsylKGRIFPVEDQLEALKSESQNkiellLQQHQDRIEQLISEH---EVEITGLTEKASSARSQANSIQsqlEIIQEQ 307

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1005 YAPIVSFEECE-RKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQendkLKKEIFTLQKDLRDKtvLIEKSHEMERALSR 1083
Cdd:pfam15921  308 ARNQNSMYMRQlSDLESTVSQLRSELREAKRMYEDKIEELEKQLV----LANSELTEARTERDQ--FSQESGNLDDQLQK 381

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1084 KTDELNKQLKDLSQKytevKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYE 1163
Cdd:pfam15921  382 LLADLHKREKELSLE----KEQNKRLWDRDTGNSITIDHLRRELDDRNMEVQRLEALLKAMKSECQGQMERQMAAIQGKN 457

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1164 KEQQTVTKLHQLLENQKNSSVPLAEHLQIK----EAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLE 1239
Cdd:pfam15921  458 ESLEKVSSLTAQLESTKEMLRKVVEELTAKkmtlESSERTVSDLTASLQEKERAIEATNAEITKLRSRVDLKLQELQHLK 537

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1240 TrEVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQ---EIKDQKERCDKS 1316
Cdd:pfam15921  538 N-EGDHLRNVQTECEALKLQMAEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEINDrrlELQEFKILKDKK 616

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1317 LTTITELQRRIQ----ESAKQIEAKDNKI----------TELLNDVERLKQALNGLSQ----LTYTSGNPTKRQSQLIDT 1378
Cdd:pfam15921  617 DAKIRELEARVSdlelEKVKLVNAGSERLravkdikqerDQLLNEVKTSRNELNSLSEdyevLKRNFRNKSEEMETTTNK 696

                          650
                   ....*....|..
gi 1034591230 1379 LQHQVKSLEQQL 1390
Cdd:pfam15921  697 LKMQLKSAQSEL 708
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 92-272 8.04e-10

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 62.76  E-value: 8.04e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230   92 FHVVTSKGNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQK-----LLQYNCPTEHADLQGRTALHDAAMADC 166
Cdd:PHA03100    39 LYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYNLTDVKeivklLLEYGANVNAPDNNGITPLLYAISKKS 118

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  167 --PSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRPT--ICQLLIDRGADVN----------------SRDKQNRTALML 226
Cdd:PHA03100   119 nsYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIDlkILKLLIDKGVDINaknrvnyllsygvpinIKDVYGFTPLHY 198

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*.
gi 1034591230  227 GCEYGCRDAVEVLIKNGADISLLDALGHDSSYYARIGDNLDILTLL 272
Cdd:PHA03100   199 AVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLL 244
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 947-1298 8.07e-10

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 63.92  E-value: 8.07e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  947 EHEAKMSSLSQSMRKVQDSNAEILANYRK--GQEEIVTLHAEIKAQKKELDtiqecIKVKYAPIVSFEECERKFKATEKE 1024
Cdd:TIGR02168  176 ETERKLERTRENLDRLEDILNELERQLKSleRQAEKAERYKELKAELRELE-----LALLVLRLEELREELEELQEELKE 250

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1025 LKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKN 1104
Cdd:TIGR02168  251 AEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELES 330

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1105 VKEKLVEEnakqtseilavqnllqkqhvpLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSsv 1184
Cdd:TIGR02168  331 KLDELAEE---------------------LAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSK-- 387

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1185 pLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNtkQALKKLETRevvdLSKYKATKSDLETQISSLN 1264
Cdd:TIGR02168  388 -VAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEE--AELKELQAE----LEELEEELEELQEELERLE 460

                          330       340       350
                   ....*....|....*....|....*....|....
gi 1034591230 1265 EKLANLNRKYEEVCEEVLHAKKKEISAKDEKELL 1298
Cdd:TIGR02168  461 EALEELREELEEAEQALDAAERELAQLQARLDSL 494
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 932-1408 8.09e-10

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 63.59  E-value: 8.09e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  932 ENTQNQIKAEYISLAEHEAKMSSLSQSMRkVQDSNAEILANYRKGQEEIVTLHAEiKAQKKELDTIQECIKVKYAPIVSF 1011
Cdd:pfam05483  175 EYEREETRQVYMDLNNNIEKMILAFEELR-VQAENARLEMHFKLKEDHEKIQHLE-EEYKKEINDKEKQVSLLLIQITEK 252

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1012 EECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEI----FTLQKDLRDKTVLIEKSHEMERALSRKTDE 1087
Cdd:pfam05483  253 ENKMKDLTFLLEESRDKANQLEEKTKLQDENLKELIEKKDHLTKELedikMSLQRSMSTQKALEEDLQIATKTICQLTEE 332

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1088 LNKQLKDLSQKYTEVKNVKEKLveenakqTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYE---- 1163
Cdd:pfam05483  333 KEAQMEELNKAKAAHSFVVTEF-------EATTCSLEELLRTEQQRLEKNEDQLKIITMELQKKSSELEEMTKFKNnkev 405

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1164 --KEQQTVTKLHQLLENQKNSSVPLAEHLQIKE--------AFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKq 1233
Cdd:pfam05483  406 elEELKKILAEDEKLLDEKKQFEKIAEELKGKEqelifllqAREKEIHDLEIQLTAIKTSEEHYLKEVEDLKTELEKEK- 484

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1234 aLKKLETREVVDL-----SKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKD 1308
Cdd:pfam05483  485 -LKNIELTAHCDKlllenKELTQEASDMTLELKKHQEDIINCKKQEERMLKQIENLEEKEMNLRDELESVREEFIQKGDE 563

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1309 QKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQ 1388
Cdd:pfam05483  564 VKCKLDKSEENARSIEYEVLKKEKQMKILENKCNNLKKQIENKNKNIEELHQENKALKKKGSAENKQLNAYEIKVNKLEL 643

                          490       500
                   ....*....|....*....|
gi 1034591230 1389 QLADADRQHQEVIAIYRTHL 1408
Cdd:pfam05483  644 ELASAKQKFEEIIDNYQKEI 663
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 482-1159 9.36e-10

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 63.50  E-value: 9.36e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  482 KLQNELAHKVAECKAL---ALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNhrl 558
Cdd:TIGR04523   44 TIKNELKNKEKELKNLdknLNKDEEKINNSNNKIKILEQQIKDLNDKLKKNKDKINKLNSDLSKINSEIKNDKEQKN--- 120

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  559 teELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEgqaKE 638
Cdd:TIGR04523  121 --KLEVELNKLEKQKKENKKNIDKFLTEIKKKEKELEKLNNKYNDLKKQKEELENELNLLEKEKLNIQKNIDKIK---NK 195

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  639 LSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVkpEEHEQVKSRLEQKS 718
Cdd:TIGR04523  196 LLKLELLLSNLKKKIQKNKSLESQISELKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLK--DEQNKIKKQLSEKQ 273

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  719 GEL---GKKITELTLKNQTLQKEIEKvyLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKY 795
Cdd:TIGR04523  274 KELeqnNKKIKELEKQLNQLKSEISD--LNNQKEQDWNKELKSELKNQEKKLEEIQNQISQNNKIISQLNEQISQLKKEL 351

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  796 TEKKLEMEKLlleNDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMM 875
Cdd:TIGR04523  352 TNSESENSEK---QRELEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEI 428

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  876 SNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSL 955
Cdd:TIGR04523  429 ERLKETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESLETQLKVLSRSINKIKQNLEQKQKELKSKEKELKKLNEEKKEL 508

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  956 SQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIqecikvkyapivsfeecerkfkatekelkdqlsEQTQK 1035
Cdd:TIGR04523  509 EEKVKDLTKKISSLKEKIEKLESEKKEKESKISDLEDELNKD---------------------------------DFELK 555

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1036 YSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKshemeraLSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAK 1115
Cdd:TIGR04523  556 KENLEKEIDEKNKEIEELKQTQKSLKKKQEEKQELIDQ-------KEKEKKDLIKEIEEKEKKISSLEKELEKAKKENEK 628

                          650       660       670       680
                   ....*....|....*....|....*....|....*....|....
gi 1034591230 1116 QTSEIlavQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQ 1159
Cdd:TIGR04523  629 LSSII---KNIKSKKNKLKQEVKQIKETIKEIRNKWPEIIKKIK 669
PTZ00121 PTZ00121
MAEBL; Provisional
 348-932 9.75e-10

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 63.62  E-value: 9.75e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  348 QLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFESDHLGSGShfSNRKEDMLLKQGQMYMADSQ 427
Cdd:PTZ00121  1294 EAKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAE--AEAAADEAEAAEEKAEAAEK 1371

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  428 CTS----PGIPAHMQSRSMLRPLELSLPSQTSYSENEILKKELEAMRTFCESAKQ-------DRLKLQNELAHKVAECKA 496
Cdd:PTZ00121  1372 KKEeakkKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKaeekkkaDEAKKKAEEAKKADEAKK 1451

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  497 LALECERVKE--DSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTE-ELKDQLKDLKVKY 573
Cdd:PTZ00121  1452 KAEEAKKAEEakKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKaEEAKKADEAKKAE 1531

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  574 EGASAEVGKLRNQIKQNEMI--VEEFKR-DEGKLIEENKRLQKELSMC----EMEREKKGRKVTEMEGQAKELSAKLALS 646
Cdd:PTZ00121  1532 EAKKADEAKKAEEKKKADELkkAEELKKaEEKKKAEEAKKAEEDKNMAlrkaEEAKKAEEARIEEVMKLYEEEKKMKAEE 1611

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  647 IPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKIT 726
Cdd:PTZ00121  1612 AKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAA 1691

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  727 ELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIE-----MKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLE 801
Cdd:PTZ00121  1692 EALKKEAEEAKKAEELKKKEAEEKKKAEELKKAeeenkIKAEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAE 1771

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  802 ----MEKLLLENDSLSKDVSRLETVfvppekhEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSN 877
Cdd:PTZ00121  1772 eirkEKEAVIEEELDEEDEKRRMEV-------DKKIKDIFDNFANIIEGGKEGNLVINDSKEMEDSAIKEVADSKNMQLE 1844

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1034591230  878 QYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLE 932
Cdd:PTZ00121  1845 EADAFEKHKFNKNNENGEDGNKEADFNKEKDLKEDDEEEIEEADEIEKIDKDDIE 1899
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1061-1434 9.80e-10

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 63.42  E-value: 9.80e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1061 QKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEAL 1140
Cdd:COG1196    221 ELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARL 300

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1141 KKSLNGTIENLKEELKSMQRcYEKEQQTVTKLHQLLENQknssvpLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEE 1220
Cdd:COG1196    301 EQDIARLEERRRELEERLEE-LEEELAELEEELEELEEE------LEELEEELEEAEEELEEAEAELAEAEEALLEAEAE 373

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1221 VSKLQSEVQNTKQALKKLETREVVDLSKYKAtksdLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAkdekellhf 1300
Cdd:COG1196    374 LAEAEEELEELAEELLEALRAAAELAAQLEE----LEEAEEALLERLERLEEELEELEEALAELEEEEEEE--------- 440

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1301 siEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTytsgnpTKRQSQLIDTLQ 1380
Cdd:COG1196    441 --EEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAE------ADYEGFLEGVKA 512

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1034591230 1381 HQVKSLEQQLADADRQHQEVIAIYRTHLLSAAQGHMDEDVQEALLQIIQMRQGL 1434
Cdd:COG1196    513 ALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEYL 566
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 100-260 1.06e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 62.29  E-value: 1.06e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  100 NLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHGAS 179
Cdd:PHA02874   103 EKDMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAY 182

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  180 VNAKDVDGRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGcRDAVEVLIKNgADISLLDALGHDSSYY 259
Cdd:PHA02874   183 ANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHN-RSAIELLINN-ASINDQDIDGSTPLHH 260


                   .
gi 1034591230  260 A 260
Cdd:PHA02874   261 A 261
PTZ00121 PTZ00121
MAEBL; Provisional
 908-1353 2.42e-09

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 62.47  E-value: 2.42e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  908 KKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDsNAEILANYRKGQEEIVTLHAEI 987
Cdd:PTZ00121  1194 RKAEDARKAEAARKAEEERKAEEARKAEDAKKAEAVKKAEEAKKDAEEAKKAEEERN-NEEIRKFEEARMAHFARRQAAI 1272

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  988 KAQ-KKELDTIQECIKVKYAPIVSFEECERKF-----KATEKELKDQLSEQTQKYSVSEEEVKKNKQENdklKKEIFTLQ 1061
Cdd:PTZ00121  1273 KAEeARKADELKKAEEKKKADEAKKAEEKKKAdeakkKAEEAKKADEAKKKAEEAKKKADAAKKKAEEA---KKAAEAAK 1349

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1062 KDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKE--KLVEENAKQTSEILAVQNLLQKQHVPLEQVEA 1139
Cdd:PTZ00121  1350 AEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEakKKAEEDKKKADELKKAAAAKKKADEAKKKAEE 1429

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1140 LKKSlngtiENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQiKEAFEKEVGiikASLREKEEESQNKME 1219
Cdd:PTZ00121  1430 KKKA-----DEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAK-KKAEEAKKA---DEAKKKAEEAKKKAD 1500

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1220 EVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLnRKYEEV--CEEVLHAKKKEiSAKDEKEL 1297
Cdd:PTZ00121  1501 EAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADEL-KKAEELkkAEEKKKAEEAK-KAEEDKNM 1578

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1034591230 1298 LHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQ 1353
Cdd:PTZ00121  1579 ALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKK 1634
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 170-267 5.06e-09

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 60.68  E-value: 5.06e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  170 IQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLIKNGADISLL 249
Cdd:PTZ00322    98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQCHFEL 177

                           90
                   ....*....|....*...
gi 1034591230  250 DALGHDSSYYARIGDNLD 267
Cdd:PTZ00322   178 GANAKPDSFTGKPPSLED 195
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 464-1410 9.02e-09

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 60.45  E-value: 9.02e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  464 KELEAMRTFCESAKQD------RLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEgkvkQMQ 537
Cdd:TIGR00606  186 KALETLRQVRQTQGQKvqehqmELKYLKQYKEKACEIRDQITSKEAQLESSREIVKSYENELDPLKNRLKEIE----HNL 261

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  538 THFLALKEHLTSEAASGNHRltEELKDQLKDLKVK-YEGASAEVGKLrnqikqnemivEEFKRDEGKLIEENK-RLQKEL 615
Cdd:TIGR00606  262 SKIMKLDNEIKALKSRKKQM--EKDNSELELKMEKvFQGTDEQLNDL-----------YHNHQRTVREKERELvDCQREL 328

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  616 SMCEMEREKKGRKVTEMEGQAKELSAKlalsipAEKFENMKSSLSNEVNEKAKKL----VEMEREHEKSLSEIRQLKREL 691
Cdd:TIGR00606  329 EKLNKERRLLNQEKTELLVEQGRLQLQ------ADRHQEHIRARDSLIQSLATRLeldgFERGPFSERQIKNFHTLVIER 402

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  692 ENVKAKLAQHVKPEEHEQVKSRLEQKSG-ELGKKITELTLKNQTLQKEIEKVYLDNKllKEQAHNLTIEMKNhyvPLKVS 770
Cdd:TIGR00606  403 QEDEAKTAAQLCADLQSKERLKQEQADEiRDEKKGLGRTIELKKEILEKKQEELKFV--IKELQQLEGSSDR---ILELD 477

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  771 EDMKKSHdaiiddlnRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRletvfvppeKHEKEIIALKSNIVELKKQLSEL 850
Cdd:TIGR00606  478 QELRKAE--------RELSKAEKNSLTETLKKEVKSLQNEKADLDRKL---------RKLDQEMEQLNHHTTTRTQMEML 540

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  851 KKKCGEDQEKIHALTSENtnlkkmmSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKikdkneilkrn 930
Cdd:TIGR00606  541 TKDKMDKDEQIRKIKSRH-------SDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELAS----------- 602

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  931 LENTQNQIKAEYISLaehEAKMSSLSQSMRKVQDSNAEilanyrkgQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVS 1010
Cdd:TIGR00606  603 LEQNKNHINNELESK---EEQLSSYEDKLFDVCGSQDE--------ESDLERLKEEIEKSSKQRAMLAGATAVYSQFITQ 671

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1011 FEE--------CERKFKaTEKELKDQLSEQTQKYSV-------SEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSH 1075
Cdd:TIGR00606  672 LTDenqsccpvCQRVFQ-TEAELQEFISDLQSKLRLapdklksTESELKKKEKRRDEMLGLAPGRQSIIDLKEKEIPELR 750

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1076 EMERALSRKTDELNKQLKDlSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGT-------- 1147
Cdd:TIGR00606  751 NKLQKVNRDIQRLKNDIEE-QETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGSDLDrtvqqvnq 829

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1148 --------IENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEvgiikasLREKEEESQNKME 1219
Cdd:TIGR00606  830 ekqekqheLDTVVSKIELNRKLIQDQQEQIQHLKSKTNELKSEKLQIGTNLQRRQQFEEQ-------LVELSTEVQSLIR 902

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1220 EVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLAN-------LNRKYEEVCEEVLHAKKKEISA- 1291
Cdd:TIGR00606  903 EIKDAKEQDSPLETFLEKDQQEKEELISSKETSNKKAQDKVNDIKEKVKNihgymkdIENKIQDGKDDYLKQKETELNTv 982

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1292 ------------KDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELlnDVERLKQALNGLS 1359
Cdd:TIGR00606  983 naqleecekhqeKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRENELKEVEEELKQHLKEMGQM--QVLQMKQEHQKLE 1060

                          970       980       990      1000      1010
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1034591230 1360 QLTYTSGNPTK----RQSQLIDTLQHQVKSL-EQQLADADRQHQEVIAIYRTHLLS 1410
Cdd:TIGR00606 1061 ENIDLIKRNHVlalgRQKGYEKEIKHFKKELrEPQFRDAEEKYREMMIVMRTTELV 1116
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 668-1361 1.47e-08

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 59.60  E-value: 1.47e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  668 KKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKsgELGKKITELTLKNQTLQKEIEKVYLDNK 747
Cdd:pfam02463  169 RKKKEALKKLIEETENLAELIIDLEELKLQELKLKEQAKKALEYYQLKEK--LELEEEYLLYLDYLKLNEERIDLLQELL 246

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  748 LLKEQAHNLTI-EMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVfvpP 826
Cdd:pfam02463  247 RDEQEEIESSKqEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKE---K 323

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  827 EKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEE----VKMTLNDTLAKTNRE 902
Cdd:pfam02463  324 KKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESErlssAAKLKEEELELKSEE 403

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  903 LLDVKKKFEDINQEFVKIKDKNEILKRNLENTQ--NQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEI 980
Cdd:pfam02463  404 EKEAQLLLELARQLEDLLKEEKKEELEILEEEEesIELKQGKLTEEKEELEKQELKLLKDELELKKSEDLLKETQLVKLQ 483

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  981 VTLHAEIKAQKKELDTIQEC----------IKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQEN 1050
Cdd:pfam02463  484 EQLELLLSRQKLEERSQKESkarsglkvllALIKDGVGGRIISAHGRLGDLGVAVENYKVAISTAVIVEVSATADEVEER 563

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1051 DKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKT--DELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEI-------- 1120
Cdd:pfam02463  564 QKLVRALTELPLGARKLRLLIPKLKLPLKSIAVLEidPILNLAQLDKATLEADEDDKRAKVVEGILKDTELTklkesaka 643

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1121 --------------------LAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQK 1180
Cdd:pfam02463  644 kesglrkgvsleeglaekseVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEIKKKEQREKEELKKLKLEAEELL 723

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1181 NSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVV---DLSKYKATKSDLE 1257
Cdd:pfam02463  724 ADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKELAEEREKTEKLKveeEKEEKLKAQEEEL 803

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1258 TQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRR--IQESAKQIE 1335
Cdd:pfam02463  804 RALEEELKEEAELLEEEQLLIEQEEKIKEEELEELALELKEEQKLEKLAEEELERLEEEITKEELLQELllKEEELEEQK 883

                          730       740
                   ....*....|....*....|....*.
gi 1034591230 1336 AKDNKITELLNDVERLKQALNGLSQL 1361
Cdd:pfam02463  884 LKDELESKEEKEKEEKKELEEESQKL 909
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 314-1058 2.00e-08

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 59.31  E-value: 2.00e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  314 QNIQDLEIENEDLKE----RLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIEAL 389
Cdd:TIGR02169  198 QQLERLRREREKAERyqalLKEKREYEGYELLKEKEALERQKEAIERQLASLEEELEKLTEEISELEKRLEEIEQLLEEL 277

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  390 KNRFKyfesdHLGSGSHFSnRKEDMLLKQGQMYMADSQctspgipahmQSRSMLRPLELSLPSQTSYSENEILKKELEAM 469
Cdd:TIGR02169  278 NKKIK-----DLGEEEQLR-VKEKIGELEAEIASLERS----------IAEKERELEDAEERLAKLEAEIDKLLAEIEEL 341

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  470 RTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDE---QIKQLEDALKDVQKRMYESEGKVKQMQThflaLKEH 546
Cdd:TIGR02169  342 EREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAEtrdELKDYREKLEKLKREINELKRELDRLQE----ELQR 417

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  547 LTSEAASGNHRLtEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEME----- 621
Cdd:TIGR02169  418 LSEELADLNAAI-AGIEAKINELEEEKEDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQRElaeae 496

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  622 --------REKKGRKVTEMEGQ------------------------------------------------AKELSAKLAL 645
Cdd:TIGR02169  497 aqaraseeRVRGGRAVEEVLKAsiqgvhgtvaqlgsvgeryataievaagnrlnnvvveddavakeaielLKRRKAGRAT 576

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  646 SIPAEKFENMKSSLS----NEVNEKAKKLVEMEREHEKSLSEIRQ---LKRELENVKAKLAQ------------------ 700
Cdd:TIGR02169  577 FLPLNKMRDERRDLSilseDGVIGFAVDLVEFDPKYEPAFKYVFGdtlVVEDIEAARRLMGKyrmvtlegelfeksgamt 656

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  701 --HVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVyldNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHD 778
Cdd:TIGR02169  657 ggSRAPRGGILFSRSEPAELQRLRERLEGLKRELSSLQSELRRI---ENRLDELSQELSDASRKIGEIEKEIEQLEQEEE 733

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  779 A---IIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKH---------EKEIIALKSNIVELKKQ 846
Cdd:TIGR02169  734 KlkeRLEELEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEEALNDLEARlshsripeiQAELSKLEEEVSRIEAR 813

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  847 LSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEI 926
Cdd:TIGR02169  814 LREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEELEAALRDLESRLGDLKKERDE 893

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  927 LK---RNLENTQNQIKAEYISLAEHeakMSSLSQSMRKVQDSNAEILANYRKGQEE------IVTLHAEIKAQKKELDTI 997
Cdd:TIGR02169  894 LEaqlRELERKIEELEAQIEKKRKR---LSELKAKLEALEEELSEIEDPKGEDEEIpeeelsLEDVQAELQRVEEEIRAL 970

                          810       820       830       840       850       860
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034591230  998 QEcikVKYAPIVSFEECERKFkatekelkDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIF 1058
Cdd:TIGR02169  971 EP---VNMLAIQEYEEVLKRL--------DELKEKRAKLEEERKAILERIEEYEKKKREVF 1020
PRK01156 PRK01156
chromosome segregation protein; Provisional
 653-1274 2.42e-08

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 58.76  E-value: 2.42e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  653 ENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLaQHVKPEEHE-----QVKSRLEQKSGELGKKITE 727
Cdd:PRK01156   189 EEKLKSSNLELENIKKQIADDEKSHSITLKEIERLSIEYNNAMDDY-NNLKSALNElssleDMKNRYESEIKTAESDLSM 267

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  728 LTLKNQTLqKEIEKVYldNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNR-----KLLDVTQKYTEKKLEM 802
Cdd:PRK01156   268 ELEKNNYY-KELEERH--MKIINDPVYKNRNYINDYFKYKNDIENKKQILSNIDAEINKyhaiiKKLSVLQKDYNDYIKK 344

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  803 EKlllENDSLSKDVSRLETvfvppekHEKEIIALKSNIVELKKQLSELKKKcgedQEKIHALTSENtnLKKMMSNQYVPV 882
Cdd:PRK01156   345 KS---RYDDLNNQILELEG-------YEMDYNSYLKSIESLKKKIEEYSKN----IERMSAFISEI--LKIQEIDPDAIK 408

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  883 KTHEEVkmtlndtlaktNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLsqsMRKV 962
Cdd:PRK01156   409 KELNEI-----------NVKLQDISSKVSSLNQRIRALRENLDELSRNMEMLNGQSVCPVCGTTLGEEKSNHI---INHY 474

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  963 QDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQEcikvkyAPIVSFEECERKFKATEKELKD------QLSEQTQKY 1036
Cdd:PRK01156   475 NEKKSRLEEKIREIEIEVKDIDEKIVDLKKRKEYLES------EEINKSINEYNKIESARADLEDikikinELKDKHDKY 548

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1037 SVSEEEVKKNKQENDKLKKEIFTLQKDLRDkTVLIEkshemerALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQ 1116
Cdd:PRK01156   549 EEIKNRYKSLKLEDLDSKRTSWLNALAVIS-LIDIE-------TNRSRSNEIKKQLNDLESRLQEIEIGFPDDKSYIDKS 620

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1117 TSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSsvplaehlqikeaf 1196
Cdd:PRK01156   621 IREIENEANNLNNKYNEIQENKILIEKLRGKIDNYKKQIAEIDSIIPDLKEITSRINDIEDNLKKS-------------- 686

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1197 EKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETRE--VVDLSKYKAT--KSDLETQI-SSLNEKLANLN 1271
Cdd:PRK01156   687 RKALDDAKANRARLESTIEILRTRINELSDRINDINETLESMKKIKkaIGDLKRLREAfdKSGVPAMIrKSASQAMTSLT 766


                   ...
gi 1034591230 1272 RKY 1274
Cdd:PRK01156   767 RKY 769
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 307-1389 2.77e-08

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 58.91  E-value: 2.77e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  307 KSHQREHQNIQDLEIENEDLK------ERLRKIQQEQRILLDKVNGLQLQLNEEVMVAddlESEREKLKSLLAAKEKQHE 380
Cdd:TIGR01612  904 KSIEEEYQNINTLKKVDEYIKicentkESIEKFHNKQNILKEILNKNIDTIKESNLIE---KSYKDKFDNTLIDKINELD 980

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  381 E-----SLRTIEALKNRF-KYFESDHLGSGSHfsnrKEDMLLKQ------------GQMYMADSQCTSPGIPAHMQSRSM 442
Cdd:TIGR01612  981 KafkdaSLNDYEAKNNELiKYFNDLKANLGKN----KENMLYHQfdekekatndieQKIEDANKNIPNIEIAIHTSIYNI 1056

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  443 LRPLELSLPSQTSYSENEILKKELEAMRTFCESakQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDV 522
Cdd:TIGR01612 1057 IDEIEKEIGKNIELLNKEILEEAEINITNFNEI--KEKLKHYNFDDFGKEENIKYADEINKIKDDIKNLDQKIDHHIKAL 1134

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  523 QKRMYESEGKVKQMQTHFLALkEHLTSEAASGNHrlTEELKDQLKDLKVKYEGAS---AEVGKLRNQIKQNEMIVEEFKR 599
Cdd:TIGR01612 1135 EEIKKKSENYIDEIKAQINDL-EDVADKAISNDD--PEEIEKKIENIVTKIDKKKniyDEIKKLLNEIAEIEKDKTSLEE 1211

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  600 DEGKLIEENKRLQKE-LSMCEMEREKKGRKVTEMEGQAKEL------SAKLALSIPAEKFENMKSSLSNEVNEKAKKLVE 672
Cdd:TIGR01612 1212 VKGINLSYGKNLGKLfLEKIDEEKKKSEHMIKAMEAYIEDLdeikekSPEIENEMGIEMDIKAEMETFNISHDDDKDHHI 1291

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  673 MEREHEKSLSEIRQ--LKRELENVKAKLAQHVKPEEHEQVkSRLEQKSGELGKKITELT-----LKNQTLQKEIEKVYLD 745
Cdd:TIGR01612 1292 ISKKHDENISDIREksLKIIEDFSEESDINDIKKELQKNL-LDAQKHNSDINLYLNEIAniyniLKLNKIKKIIDEVKEY 1370

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  746 NKLLKEQAHNLTIEMKNHYVPLKVSED---MKKSHDAIIDDLNRKLLD-VTQKYTEKKLEMEKLLLENDSL-------SK 814
Cdd:TIGR01612 1371 TKEIEENNKNIKDELDKSEKLIKKIKDdinLEECKSKIESTLDDKDIDeCIKKIKELKNHILSEESNIDTYfknadenNE 1450

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  815 DVSRLETVFVPPEKHEKEIIALKS---------NIVELKKQLSElKKKCGEDQEKIHALTSENTNLKK-------MMSNQ 878
Cdd:TIGR01612 1451 NVLLLFKNIEMADNKSQHILKIKKdnatndhdfNINELKEHIDK-SKGCKDEADKNAKAIEKNKELFEqykkdvtELLNK 1529

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  879 YVPVKTHEEVKMTLNDTLAKTNrELLDVKKKF----EDINQEFVKIKDKNEILKRNLENTQNQIKAEY---ISLAEHEAK 951
Cdd:TIGR01612 1530 YSALAIKNKFAKTKKDSEIIIK-EIKDAHKKFileaEKSEQKIKEIKKEKFRIEDDAAKNDKSNKAAIdiqLSLENFENK 1608

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  952 MSSLSQSMRKVQDSNAEILANYRK-GQEEIVTLHAEIKAQKKELDTIQECIKvkyapivSFEECERKFKATEKELkDQLS 1030
Cdd:TIGR01612 1609 FLKISDIKKKINDCLKETESIEKKiSSFSIDSQDTELKENGDNLNSLQEFLE-------SLKDQKKNIEDKKKEL-DELD 1680

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1031 EQTQKYSVSEEEVKKNKQEN--DKLKKEIFTLQKDLRDKTVLIEKSheMERALS-------------RKTDELNKQLKDL 1095
Cdd:TIGR01612 1681 SEIEKIEIDVDQHKKNYEIGiiEKIKEIAIANKEEIESIKELIEPT--IENLISsfntndlegidpnEKLEEYNTEIGDI 1758

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1096 SQKYTEVKNV---------KEKLVEENAKQT-----SEILAVQNLLQKQHVPLEQVEAlkKSLNGTIENLKEELKSMQRC 1161
Cdd:TIGR01612 1759 YEEFIELYNIiagcletvsKEPITYDEIKNTrinaqNEFLKIIEIEKKSKSYLDDIEA--KEFDRIINHFKKKLDHVNDK 1836

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1162 YEKEQQTVTK----LHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQS----EVQNTkQ 1233
Cdd:TIGR01612 1837 FTKEYSKINEgfddISKSIENVKNSTDENLLFDILNKTKDAYAGIIGKKYYSYKDEAEKIFINISKLANsiniQIQNN-S 1915

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1234 ALKKLETREVVDLSKYKATKSDLETQISSlNEKLANLNRKYEEVCEEVLHA-KKKEISAKDEKELLHFSIEQEIKDQKER 1312
Cdd:TIGR01612 1916 GIDLFDNINIAILSSLDSEKEDTLKFIPS-PEKEPEIYTKIRDSYDTLLDIfKKSQDLHKKEQDTLNIIFENQQLYEKIQ 1994

                         1130      1140      1150      1160      1170      1180      1190
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034591230 1313 CDKSLttitelqrriQESAKQIEAKDNKItelLNDVERLKQALNGLSQLTYTSGN-PTKRQSQLIDTLQHQVKSLEQQ 1389
Cdd:TIGR01612 1995 ASNEL----------KDTLSDLKYKKEKI---LNDVKLLLHKFDELNKLSCDSQNyDTILELSKQDKIKEKIDNYEKE 2059
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 69-242 3.52e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 57.58  E-value: 3.52e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230   69 KVTSILAKKGVNPGKLDVE-GRSVFHVVTSKGNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPT 147
Cdd:PHA02878   148 EITKLLLSYGADINMKDRHkGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGAST 227

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  148 EHADLQGRTALHdAAMADCPSS--IQLLCDHGASVNAKD-VDGRTPLVLATQMSRPTicQLLIDRGADVNSRDKQNRTAL 224
Cdd:PHA02878   228 DARDKCGNTPLH-ISVGYCKDYdiLKLLLEHGVDVNAKSyILGLTALHSSIKSERKL--KLLLEYGADINSLNSYKLTPL 304

                          170
                   ....*....|....*....
gi 1034591230  225 -MLGCEYGCRDAVEVLIKN 242
Cdd:PHA02878   305 sSAVKQYLCINIGRILISN 323
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 458-851 8.15e-08

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 57.05  E-value: 8.15e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  458 ENEILKKeLEAMRTFCESAKQDRLKLQNELAHKvaeckalalecERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQ 537
Cdd:pfam15921  456 KNESLEK-VSSLTAQLESTKEMLRKVVEELTAK-----------KMTLESSERTVSDLTASLQEKERAIEATNAEITKLR 523

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  538 THF-LALKE--HLTSEAASGNHRLTEelkdqLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKE 614
Cdd:pfam15921  524 SRVdLKLQElqHLKNEGDHLRNVQTE-----CEALKLQMAEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKE 598

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  615 LSMCEMEREKKGRKVTEMEGQAKELSAKLAlsipaeKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENV 694
Cdd:pfam15921  599 INDRRLELQEFKILKDKKDAKIRELEARVS------DLELEKVKLVNAGSERLRAVKDIKQERDQLLNEVKTSRNELNSL 672

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  695 KaklaqhvkpEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIekvyldnkllkEQAHNLTIEMK-NHYVPLKVSEDM 773
Cdd:pfam15921  673 S---------EDYEVLKRNFRNKSEEMETTTNKLKMQLKSAQSEL-----------EQTRNTLKSMEgSDGHAMKVAMGM 732

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  774 KKSHDAI---IDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSrleTVFVPPEKHEKEIIALKSNIVELKKQLSEL 850
Cdd:pfam15921  733 QKQITAKrgqIDALQSKIQFLEEAMTNANKEKHFLKEEKNKLSQELS---TVATEKNKMAGELEVLRSQERRLKEKVANM 809


                   .
gi 1034591230  851 K 851
Cdd:pfam15921  810 E 810
Ank_4 pfam13637
Ankyrin repeats (many copies);
154-207 1.00e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 49.97  E-value: 1.00e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1034591230  154 GRTALHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLI 207
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PTZ00121 PTZ00121
MAEBL; Provisional
 273-938 1.01e-07

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 57.07  E-value: 1.01e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  273 KTASENTNKGRELWKKGPSLQQRN-LTHMQDEVNVKSHQREHQNIQDLEIENEDLK---ERLRKIQQEQRilldKVNGLQ 348
Cdd:PTZ00121  1322 KKAEEAKKKADAAKKKAEEAKKAAeAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKkkaDAAKKKAEEKK----KADEAK 1397

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  349 LQLNEEVMVADDLESEREKLKSLLAAKEKQhEESLRTIEALKNRFKYFESDHLGSGSHFSNRKEDMLLKQGQMYMADSqc 428
Cdd:PTZ00121  1398 KKAEEDKKKADELKKAAAAKKKADEAKKKA-EEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADE-- 1474

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  429 tspgipAHMQSRSMLRPLELSLPSQTSYSENEILKKELEAMRTFCESAKQDRLKLQNELahKVAECKALALECERVKEDS 508
Cdd:PTZ00121  1475 ------AKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEA--KKAEEAKKADEAKKAEEKK 1546

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  509 D-EQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASgnhRLTEELKDQLKDLKVKYEGA-SAEVGKLR-N 585
Cdd:PTZ00121  1547 KaDELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEA---RIEEVMKLYEEEKKMKAEEAkKAEEAKIKaE 1623

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  586 QIKQNEMI---VEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAklalsipAEKFENMKSSLSNE 662
Cdd:PTZ00121  1624 ELKKAEEEkkkVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKK-------AEEDEKKAAEALKK 1696

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  663 VNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKIteltlknQTLQKEIEKV 742
Cdd:PTZ00121  1697 EAEEAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEAKKDEEEKKKI-------AHLKKEEEKK 1769

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  743 YLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMK--KSHDAIIDDLNRKlldvTQKYTEKKLEMEKLLLENDSLSKDVSRLE 820
Cdd:PTZ00121  1770 AEEIRKEKEAVIEEELDEEDEKRRMEVDKKIKdiFDNFANIIEGGKE----GNLVINDSKEMEDSAIKEVADSKNMQLEE 1845

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  821 TVFVPPEKHEKEIIALKSNIvelKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPvktheevkmtlNDTLAKTN 900
Cdd:PTZ00121  1846 ADAFEKHKFNKNNENGEDGN---KEADFNKEKDLKEDDEEEIEEADEIEKIDKDDIEREIP-----------NNNMAGKN 1911

                          650       660       670
                   ....*....|....*....|....*....|....*...
gi 1034591230  901 RELLDVKkkfedinqefvkiKDKNEILKRNLENTQNQI 938
Cdd:PTZ00121  1912 NDIIDDK-------------LDKDEYIKRDAEETREEI 1936
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 99-280 1.10e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 56.15  E-value: 1.10e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230   99 GNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHGA 178
Cdd:PHA02875    13 GELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGK 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  179 SVNakDV---DGRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLIKNGADISLLDALGHD 255
Cdd:PHA02875    93 FAD--DVfykDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCT 170

                          170       180
                   ....*....|....*....|....*
gi 1034591230  256 SSYYARIGDNLDILTLLKTASENTN 280
Cdd:PHA02875   171 PLIIAMAKGDIAICKMLLDSGANID 195
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 892-1391 1.21e-07

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 56.48  E-value: 1.21e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  892 LNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILA 971
Cdd:COG1196    237 LEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEE 316

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  972 NYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQEND 1051
Cdd:COG1196    317 RLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAA 396

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1052 KLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKqh 1131
Cdd:COG1196    397 ELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAAL-- 474

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1132 vpLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHqLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASL---- 1207
Cdd:COG1196    475 --LEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAAL-LLAGLRGLAGAVAVLIGVEAAYEAALEAALAAAlqni 551

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1208 ---------REKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVD-------------------LSKYKATKSDLETQ 1259
Cdd:COG1196    552 vveddevaaAAIEYLKAAKAGRATFLPLDKIRARAALAAALARGAIGaavdlvasdlreadaryyvLGDTLLGRTLVAAR 631

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1260 ISSLNEKLANLNRKYEEV---CEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEA 1336
Cdd:COG1196    632 LEAALRRAVTLAGRLREVtleGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAE 711

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034591230 1337 KDNKITELLNDVERLKQALNGLSQ-----------LTYTSGNPTKRQSQLIDTLQHQVKSLEQQLA 1391
Cdd:COG1196    712 AEEERLEEELEEEALEEQLEAEREelleelleeeeLLEEEALEELPEPPDLEELERELERLEREIE 777
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
 652-920 1.51e-07

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 56.09  E-value: 1.51e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  652 FENMKSSLSNEVNEKAKKLVEMEREHeksLSEIRQLkRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLK 731
Cdd:PRK05771    33 IEDLKEELSNERLRKLRSLLTKLSEA---LDKLRSY-LPKLNPLREEKKKVSVKSLEELIKDVEEELEKIEKEIKELEEE 108

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  732 NQTLQKEIEKvYLDNKLLKEQAHNLTIEMKNHY-------VPLKVSEDMKKSHDAIIDDLNRKLLDVTQKY------TEK 798
Cdd:PRK05771   109 ISELENEIKE-LEQEIERLEPWGNFDLDLSLLLgfkyvsvFVGTVPEDKLEELKLESDVENVEYISTDKGYvyvvvvVLK 187

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  799 KL--EMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMS 876
Cdd:PRK05771   188 ELsdEVEEELKKLGFERLELEEEGTPSELIREIKEELEEIEKERESLLEELKELAKKYLEELLALYEYLEIELERAEALS 267

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034591230  877 NQ-----------YVPVKTHEEVKMTLNDTlakTNR----ELLDVKKKFEDI-----NQEFVKI 920
Cdd:PRK05771   268 KFlktdktfaiegWVPEDRVKKLKELIDKA---TGGsayvEFVEPDEEEEEVptklkNPKFIKP 328
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
925-1353 1.82e-07

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 55.82  E-value: 1.82e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  925 EILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVK 1004
Cdd:PRK02224   254 ETLEAEIEDLRETIAETEREREELAEEVRDLRERLEELEEERDDLLAEAGLDDADAEAVEARREELEDRDEELRDRLEEC 333

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1005 YAPIVSF-EECERKFKATE------KELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEM 1077
Cdd:PRK02224   334 RVAAQAHnEEAESLREDADdleeraEELREEAAELESELEEAREAVEDRREEIEELEEEIEELRERFGDAPVDLGNAEDF 413

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1078 ERALSRKTDELNKQLKDLSQKYTEVKNVKEK---LVE-----------ENAKQTSEILAVQNLLQKQHVPLEQVEALKKS 1143
Cdd:PRK02224   414 LEELREERDELREREAELEATLRTARERVEEaeaLLEagkcpecgqpvEGSPHVETIEEDRERVEELEAELEDLEEEVEE 493

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1144 LNGTIENLkEELKSMQRCYEKEQQTVTKLHQLLENQKNS----SVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKME 1219
Cdd:PRK02224   494 VEERLERA-EDLVEAEDRIERLEERREDLEELIAERRETieekRERAEELRERAAELEAEAEEKREAAAEAEEEAEEARE 572

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1220 EVSKLQSEVQNTKQALKKLETREVVDlskykATKSDLETQISSLNEKLANLNRKYEEVCEEVlhAKKKEISAKDEKELLH 1299
Cdd:PRK02224   573 EVAELNSKLAELKERIESLERIRTLL-----AAIADAEDEIERLREKREALAELNDERRERL--AEKRERKRELEAEFDE 645

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1034591230 1300 FSIEqEIKDQKERCDKSLTTITELQRRIQES----AKQIEAKDNKITELLNDVERLKQ 1353
Cdd:PRK02224   646 ARIE-EAREDKERAEEYLEQVEEKLDELREErddlQAEIGAVENELEELEELRERREA 702
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 827-1067 3.88e-07

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 54.00  E-value: 3.88e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  827 EKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNqyvpvktheevkmtLNDTLAKTNRELLDV 906
Cdd:COG4942     23 AEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRA--------------LEQELAALEAELAEL 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  907 KKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAE 986
Cdd:COG4942     89 EKEIAELRAELEAQKEELAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAE 168

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  987 IKAQKKELDTIQEcikvkyapivSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRD 1066
Cdd:COG4942    169 LEAERAELEALLA----------ELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAA 238


                   .
gi 1034591230 1067 K 1067
Cdd:COG4942    239 A 239
Ank_4 pfam13637
Ankyrin repeats (many copies);
88-141 6.85e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 47.27  E-value: 6.85e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1034591230   88 GRSVFHVVTSKGNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLL 141
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 299-1239 1.02e-06

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 53.51  E-value: 1.02e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  299 HMQDEVNVKSHQREHQN--IQDLEIENEDLKERLRKIQQEQRILldkvnglqLQLNEEVMVADDLESEREKLKSLLaaKE 376
Cdd:TIGR00606  221 EIRDQITSKEAQLESSReiVKSYENELDPLKNRLKEIEHNLSKI--------MKLDNEIKALKSRKKQMEKDNSEL--EL 290

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  377 KQHEESLRTIEALKNRFKYFESDHLGSGSHFS--------NRKEDMLLKQGQMYM----ADSQCTSPGIPAHMQSRSMLR 444
Cdd:TIGR00606  291 KMEKVFQGTDEQLNDLYHNHQRTVREKERELVdcqrelekLNKERRLLNQEKTELlveqGRLQLQADRHQEHIRARDSLI 370

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  445 pLELSLPSQTSYSENE-ILKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALAlecervkedsDEQIKQLEDALKDVQ 523
Cdd:TIGR00606  371 -QSLATRLELDGFERGpFSERQIKNFHTLVIERQEDEAKTAAQLCADLQSKERLK----------QEQADEIRDEKKGLG 439

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  524 KRMYESEGKVKQMQTHFLALKEHLTSEAASGNH--RLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMI-VEEFKRD 600
Cdd:TIGR00606  440 RTIELKKEILEKKQEELKFVIKELQQLEGSSDRilELDQELRKAERELSKAEKNSLTETLKKEVKSLQNEKAdLDRKLRK 519

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  601 EGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIP----AEKFENMKSSLSNEVNEKAKKLVEMERE 676
Cdd:TIGR00606  520 LDQEMEQLNHHTTTRTQMEMLTKDKMDKDEQIRKIKSRHSDELTSLLGyfpnKKQLEDWLHSKSKEINQTRDRLAKLNKE 599

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  677 HEKSLSEIRQLKRELENVKAKLaqhvkpeeheqvkSRLEQKSGEL-GKKITELTLKNqtLQKEIEKVYLDNKLLKEQAH- 754
Cdd:TIGR00606  600 LASLEQNKNHINNELESKEEQL-------------SSYEDKLFDVcGSQDEESDLER--LKEEIEKSSKQRAMLAGATAv 664

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  755 ------NLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFvppEK 828
Cdd:TIGR00606  665 ysqfitQLTDENQSCCPVCQRVFQTEAELQEFISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLAPGRQSII---DL 741

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  829 HEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVK--------MTLNDTLAKTN 900
Cdd:TIGR00606  742 KEKEIPELRNKLQKVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELKdverkiaqQAAKLQGSDLD 821

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  901 RELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQdsnaeilanyrKGQEEI 980
Cdd:TIGR00606  822 RTVQQVNQEKQEKQHELDTVVSKIELNRKLIQDQQEQIQHLKSKTNELKSEKLQIGTNLQRRQ-----------QFEEQL 890

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  981 VTLHAEikaqkkeldtIQECIKvkyapivSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTL 1060
Cdd:TIGR00606  891 VELSTE----------VQSLIR-------EIKDAKEQDSPLETFLEKDQQEKEELISSKETSNKKAQDKVNDIKEKVKNI 953

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1061 QKDLRDKTVLIEKSheMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLveENAKQTSEILAVQNLLQKQHVPLEQVEAL 1140
Cdd:TIGR00606  954 HGYMKDIENKIQDG--KDDYLKQKETELNTVNAQLEECEKHQEKINEDM--RLMRQDIDTQKIQERWLQDNLTLRKRENE 1029

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1141 KKSLNGTIENLKEELKSMQRCYEKeqQTVTKLHQLLENQKNSSVPLAEHLQikeAFEKEVGIIKASLREKeeESQNKMEE 1220
Cdd:TIGR00606 1030 LKEVEEELKQHLKEMGQMQVLQMK--QEHQKLEENIDLIKRNHVLALGRQK---GYEKEIKHFKKELREP--QFRDAEEK 1102

                          970
                   ....*....|....*....
gi 1034591230 1221 VSKLQSEVQNTKQALKKLE 1239
Cdd:TIGR00606 1103 YREMMIVMRTTELVNKDLD 1121
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 908-1122 1.63e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 52.07  E-value: 1.63e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  908 KKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEI 987
Cdd:COG4942     20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAEL 99

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  988 KAQKKE----LDTIQECIKVKY-APIVSFEECERKFKATE--KELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTL 1060
Cdd:COG4942    100 EAQKEElaelLRALYRLGRQPPlALLLSPEDFLDAVRRLQylKYLAPARREQAEELRADLAELAALRAELEAERAELEAL 179

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034591230 1061 QKDLRDK----TVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILA 1122
Cdd:COG4942    180 LAELEEEraalEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPA 245
PRK01156 PRK01156
chromosome segregation protein; Provisional
 799-1356 1.67e-06

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 52.98  E-value: 1.67e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  799 KLEMEKLLLEN--DSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMS 876
Cdd:PRK01156   163 SLERNYDKLKDviDMLRAEISNIDYLEEKLKSSNLELENIKKQIADDEKSHSITLKEIERLSIEYNNAMDDYNNLKSALN 242

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  877 NQyvpvktheevkMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLS 956
Cdd:PRK01156   243 EL-----------SSLEDMKNRYESEIKTAESDLSMELEKNNYYKELEERHMKIINDPVYKNRNYINDYFKYKNDIENKK 311

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  957 QSMRKVQDSNAEILANYRKgQEEIVTLHAEIKAQKKELDTIQECI------KVKYAPIV-SFEECERKFKATEKELKDQL 1029
Cdd:PRK01156   312 QILSNIDAEINKYHAIIKK-LSVLQKDYNDYIKKKSRYDDLNNQIlelegyEMDYNSYLkSIESLKKKIEEYSKNIERMS 390

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1030 SEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLK------DLSQKYTEvk 1103
Cdd:PRK01156   391 AFISEILKIQEIDPDAIKKELNEINVKLQDISSKVSSLNQRIRALRENLDELSRNMEMLNGQSVcpvcgtTLGEEKSN-- 468

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1104 NVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGtiENLKEelksmqrcYEKEQQTVTKLHQLLENQKNSS 1183
Cdd:PRK01156   469 HIINHYNEKKSRLEEKIREIEIEVKDIDEKIVDLKKRKEYLES--EEINK--------SINEYNKIESARADLEDIKIKI 538

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1184 VPLAE-HLQIKEAFEKEVGIIKASLREKEEESQNKMEEVS-----KLQSEVQNTKQALKKLETREVVDLSKYKATKSDLE 1257
Cdd:PRK01156   539 NELKDkHDKYEEIKNRYKSLKLEDLDSKRTSWLNALAVISlidieTNRSRSNEIKKQLNDLESRLQEIEIGFPDDKSYID 618

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1258 TQISSLNEKLANLNRKYEEVCE-----EVLHAK----KKEISAKDEkellhfsIEQEIKDQKERCDKSLTTITELQRRIQ 1328
Cdd:PRK01156   619 KSIREIENEANNLNNKYNEIQEnkiliEKLRGKidnyKKQIAEIDS-------IIPDLKEITSRINDIEDNLKKSRKALD 691

                          570       580
                   ....*....|....*....|....*...
gi 1034591230 1329 ESAKQIEAKDNKITELLNDVERLKQALN 1356
Cdd:PRK01156   692 DAKANRARLESTIEILRTRINELSDRIN 719
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 917-1389 2.14e-06

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 52.66  E-value: 2.14e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  917 FVKIKDKNEILKRNLENTQNQIKAeyisLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDT 996
Cdd:TIGR00618  367 IREISCQQHTLTQHIHTLQQQKTT----LTQKLQSLCKELDILQREQATIDTRTSAFRDLQGQLAHAKKQQELQQRYAEL 442

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  997 ----IQECIKVKYAPIVSFEECERKFKATEKELKD--QLSEQTQKYSVSEEEVKKNKQENDK-LKKEIFTLQKDLRDKTV 1069
Cdd:TIGR00618  443 caaaITCTAQCEKLEKIHLQESAQSLKEREQQLQTkeQIHLQETRKKAVVLARLLELQEEPCpLCGSCIHPNPARQDIDN 522

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1070 LIEKSHEMERALSRKT-------------DELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQ 1136
Cdd:TIGR00618  523 PGPLTRRMQRGEQTYAqletseedvyhqlTSERKQRASLKEQMQEIQQSFSILTQCDNRSKEDIPNLQNITVRLQDLTEK 602

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1137 VEALKKSLNGTIENLKEELK----------SMQRCYEKEQQTVTKLHQLLENQKNSSVplAEHLQIKEAFEKEVGiikAS 1206
Cdd:TIGR00618  603 LSEAEDMLACEQHALLRKLQpeqdlqdvrlHLQQCSQELALKLTALHALQLTLTQERV--REHALSIRVLPKELL---AS 677

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1207 LREKEEESQNKMEEVSKLQSEVQNTKQALKKLET------REVVDLSKYKAT-KSDLETQISSLNEKLANLNRKYEEVCE 1279
Cdd:TIGR00618  678 RQLALQKMQSEKEQLTYWKEMLAQCQTLLRELEThieeydREFNEIENASSSlGSDLAAREDALNQSLKELMHQARTVLK 757

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1280 E--VLHAKKKEISAKDEKELLHFS-IEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLndVERLKQALN 1356
Cdd:TIGR00618  758 ArtEAHFNNNEEVTAALQTGAELShLAAEIQFFNRLREEDTHLLKTLEAEIGQEIPSDEDILNLQCETL--VQEEEQFLS 835

                          490       500       510
                   ....*....|....*....|....*....|...
gi 1034591230 1357 GLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQ 1389
Cdd:TIGR00618  836 RLEEKSATLGEITHQLLKYEECSKQLAQLTQEQ 868
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 170-272 2.38e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 51.80  E-value: 2.38e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  170 IQLLCDHGASVNAKDVD-GRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLIKNGADISL 248
Cdd:PHA02878   150 TKLLLSYGADINMKDRHkGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDA 229

                           90       100
                   ....*....|....*....|....*...
gi 1034591230  249 LDALG----HDSSYYARigdNLDILTLL 272
Cdd:PHA02878   230 RDKCGntplHISVGYCK---DYDILKLL 254
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 505-1273 2.51e-06

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 52.28  E-value: 2.51e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  505 KEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAasgnhrLTEELKDQLKDLKVKYEGASAEVGKLR 584
Cdd:TIGR00618  159 KAKSKEKKELLMNLFPLDQYTQLALMEFAKKKSLHGKAELLTLRSQL------LTLCTPCMPDTYHERKQVLEKELKHLR 232

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  585 NQIKQnEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKkgrkvtemegqAKELSAKLALSIPAEKFENMKSSLSnevn 664
Cdd:TIGR00618  233 EALQQ-TQQSHAYLTQKREAQEEQLKKQQLLKQLRARIEE-----------LRAQEAVLEETQERINRARKAAPLA---- 296

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  665 EKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQksgelgkkitelTLKNQTLQKEIE-KVY 743
Cdd:TIGR00618  297 AHIKAVTQIEQQAQRIHTELQSKMRSRAKLLMKRAAHVKQQSSIEEQRRLLQ------------TLHSQEIHIRDAhEVA 364

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  744 LDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVF 823
Cdd:TIGR00618  365 TSIREISCQQHTLTQHIHTLQQQKTTLTQKLQSLCKELDILQREQATIDTRTSAFRDLQGQLAHAKKQQELQQRYAELCA 444

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  824 VPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQ------EKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLA 897
Cdd:TIGR00618  445 AAITCTAQCEKLEKIHLQESAQSLKEREQQLQTKEqihlqeTRKKAVVLARLLELQEEPCPLCGSCIHPNPARQDIDNPG 524

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  898 KTNRELLdvkkkfedinqefvKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQ 977
Cdd:TIGR00618  525 PLTRRMQ--------------RGEQTYAQLETSEEDVYHQLTSERKQRASLKEQMQEIQQSFSILTQCDNRSKEDIPNLQ 590

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  978 EEIVTLHAEIKAQKKEldtiqecikvkyapivsfeecERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDK---LK 1054
Cdd:TIGR00618  591 NITVRLQDLTEKLSEA---------------------EDMLACEQHALLRKLQPEQDLQDVRLHLQQCSQELALKltaLH 649

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1055 KEIFTLQKDLRDKTVLIEKSHEMERALSRKtdelnKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPL 1134
Cdd:TIGR00618  650 ALQLTLTQERVREHALSIRVLPKELLASRQ-----LALQKMQSEKEQLTYWKEMLAQCQTLLRELETHIEEYDREFNEIE 724

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1135 EQVEALKKSLNGTIENLKEELKSMQRcyekEQQTVTKLHQLLENQKNSSVPLAEHLQIKEA--------FEKEVGIIKAS 1206
Cdd:TIGR00618  725 NASSSLGSDLAAREDALNQSLKELMH----QARTVLKARTEAHFNNNEEVTAALQTGAELShlaaeiqfFNRLREEDTHL 800

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1207 LREKEEESQNKME--------EVSKLQSEVQNTKQALKKLETR---------EVVDLSKYKATKSDLETQISSLNEKLAN 1269
Cdd:TIGR00618  801 LKTLEAEIGQEIPsdedilnlQCETLVQEEEQFLSRLEEKSATlgeithqllKYEECSKQLAQLTQEQAKIIQLSDKLNG 880


                   ....
gi 1034591230 1270 LNRK 1273
Cdd:TIGR00618  881 INQI 884
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 125-253 2.83e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 51.94  E-value: 2.83e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  125 LHLAAKYGHALCLQKLLQYNcpteHADLQ-----GRTALHDAAMADCPSSIQLLCDhgasvNAKDV----------DGRT 189
Cdd:cd22192     21 LLLAAKENDVQAIKKLLKCP----SCDLFqrgalGETALHVAALYDNLEAAVVLME-----AAPELvnepmtsdlyQGET 91

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034591230  190 PLVLATQMSRPTICQLLIDRGADVNSRD------KQNRTALMLGCEY--------GCRDAVEVLIKNGADISLLDALG 253
Cdd:cd22192     92 ALHIAVVNQNLNLVRELIARGADVVSPRatgtffRPGPKNLIYYGEHplsfaacvGNEEIVRLLIEHGADIRAQDSLG 169
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
967-1418 3.23e-06

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 51.69  E-value: 3.23e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  967 AEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKvKYAPIVSFEECERKFKATEKELKdQLSEQTQKYSVSEEEVKKN 1046
Cdd:COG4717     84 EEKEEEYAELQEELEELEEELEELEAELEELREELE-KLEKLLQLLPLYQELEALEAELA-ELPERLEELEERLEELREL 161

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1047 KQENDKLKKEIFTLQKDLRDKtvLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKL--VEENAKQTSEILAVQ 1124
Cdd:COG4717    162 EEELEELEAELAELQEELEEL--LEQLSLATEEELQDLAEELEELQQRLAELEEELEEAQEELeeLEEELEQLENELEAA 239

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1125 NLLQKQHVPLEQ---------VEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEA 1195
Cdd:COG4717    240 ALEERLKEARLLlliaaallaLLGLGGSLLSLILTIAGVLFLVLGLLALLFLLLAREKASLGKEAEELQALPALEELEEE 319

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1196 fekEVGIIKASLREKEEESQnkmEEVSKLQSEVQNTKQALKKLETREvvdlskYKATKSDLETQISSLnekLANLNRKYE 1275
Cdd:COG4717    320 ---ELEELLAALGLPPDLSP---EELLELLDRIEELQELLREAEELE------EELQLEELEQEIAAL---LAEAGVEDE 384

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1276 EVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKslTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQAL 1355
Cdd:COG4717    385 EELRAALEQAEEYQELKEELEELEEQLEELLGELEELLEA--LDEEELEEELEELEEELEELEEELEELREELAELEAEL 462

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034591230 1356 NGLsqltytsgnptkRQSQLIDTLQHQVKSLEQQLADADRQHQeVIAIYRTHLLSAAQGHMDE 1418
Cdd:COG4717    463 EQL------------EEDGELAELLQELEELKAELRELAEEWA-ALKLALELLEEAREEYREE 512
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 970-1270 5.73e-06

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 51.09  E-value: 5.73e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  970 LANYRKGQEEIVTLHAEIKAQKKELDTIQecikvkyapivsfeecerkfkATEKELKDQLSEQTQKYSVSEEEVKKNKQE 1049
Cdd:COG1196    231 LLKLRELEAELEELEAELEELEAELEELE---------------------AELAELEAELEELRLELEELELELEEAQAE 289

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1050 NDKLKKEIFTLQKDlrdktvlIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQK 1129
Cdd:COG1196    290 EYELLAELARLEQD-------IARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAE 362

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1130 QhvpLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEvgiiKASLRE 1209
Cdd:COG1196    363 A---EEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEA----LAELEE 435

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034591230 1210 KEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANL 1270
Cdd:COG1196    436 EEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLL 496
PRK04778 PRK04778
septation ring formation regulator EzrA; Provisional
 1017-1335 6.11e-06

septation ring formation regulator EzrA; Provisional


Pssm-ID: 179877 [Multi-domain]  Cd Length: 569  Bit Score: 50.60  E-value: 6.11e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1017 KFKATEKELKD---QLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRD--KTVLiEKSHEMERALsrktDELNKQ 1091
Cdd:PRK04778    99 RFRKAKHEINEiesLLDLIEEDIEQILEELQELLESEEKNREEVEQLKDLYRElrKSLL-ANRFSFGPAL----DELEKQ 173

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1092 LKDLSQKYTEVKNVKEklvEENAKQTSEILAVQ----NLLQKQ--HVPlEQVEALKKSLNGTIENLKEELKSMQRC-YEK 1164
Cdd:PRK04778   174 LENLEEEFSQFVELTE---SGDYVEAREILDQLeeelAALEQImeEIP-ELLKELQTELPDQLQELKAGYRELVEEgYHL 249

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1165 EQQTVTKLHQLLENQKNSSVPLAEHLQIKEAfEKEVGIIKA------SLREKEEESQNKMEE-VSKLQSEVQNTKQALKK 1237
Cdd:PRK04778   250 DHLDIEKEIQDLKEQIDENLALLEELDLDEA-EEKNEEIQEridqlyDILEREVKARKYVEKnSDTLPDFLEHAKEQNKE 328

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1238 LETR-EVVDLSkYKATKSDLETQiSSLNEKLANLNRKYEEVCEEVlhaKKKEISakdekellhFSieqEIKDQKERCDKS 1316
Cdd:PRK04778   329 LKEEiDRVKQS-YTLNESELESV-RQLEKQLESLEKQYDEITERI---AEQEIA---------YS---ELQEELEEILKQ 391

                          330
                   ....*....|....*....
gi 1034591230 1317 LTTITELQRRIQESAKQIE 1335
Cdd:PRK04778   392 LEEIEKEQEKLSEMLQGLR 410
PHA02798 PHA02798
ankyrin-like protein; Provisional
 170-268 6.11e-06

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 50.60  E-value: 6.11e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  170 IQLLCDHGASVNAKDVDGRTPLV-----LATQMSRPTICQLLIDRGADVNSRDKQNRTAL--MLGCEY-GCRDAVEVLIK 241
Cdd:PHA02798    54 VKLFINLGANVNGLDNEYSTPLCtilsnIKDYKHMLDIVKILIENGADINKKNSDGETPLycLLSNGYiNNLEILLFMIE 133

                           90       100
                   ....*....|....*....|....*...
gi 1034591230  242 NGADISLLDALGHDS-SYYARIGDNLDI 268
Cdd:PHA02798   134 NGADTTLLDKDGFTMlQVYLQSNHHIDI 161
Ank_2 pfam12796
Ankyrin repeats (3 copies);
191-272 7.12e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 45.88  E-value: 7.12e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  191 LVLATQMSRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLIKNGAdislLDALGHDSS--YYARIGDNLDI 268
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHAD----VNLKDNGRTalHYAARSGHLEI 76


                   ....
gi 1034591230  269 LTLL 272
Cdd:pfam12796   77 VKLL 80
COG5022 COG5022
Myosin heavy chain [General function prediction only];
831-1361 8.97e-06

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 50.46  E-value: 8.97e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  831 KEIIALKSNIVELKKQLSELKKKCGED-QEKIHALTSENTNLKKMMSNqyVPVKTHEEVKMTLNDTLAKtnreLLDVKKK 909
Cdd:COG5022    892 KSISSLKLVNLELESEIIELKKSLSSDlIENLEFKTELIARLKKLLNN--IDLEEGPSIEYVKLPELNK----LHEVESK 965

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  910 FEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQS---MRKVQDSNAEILANYRKGQEEIVTLHAE 986
Cdd:COG5022    966 LKETSEEYEDLLKKSTILVREGNKANSELKNFKKELAELSKQYGALQEStkqLKELPVEVAELQSASKIISSESTELSIL 1045

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  987 IKAQK-------KELDTIQECIKVKYAPIVSFEEC------------ERKFKATEKELKDQ-----------LSEQTQKY 1036
Cdd:COG5022   1046 KPLQKlkgllllENNQLQARYKALKLRRENSLLDDkqlyqlestenlLKTINVKDLEVTNRnlvkpanvlqfIVAQMIKL 1125

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1037 SVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMER----ALSRKTDELNKQLKDLSQKYT----EVKNVKEK 1108
Cdd:COG5022   1126 NLLQEISKFLSQLVNTLEPVFQKLSVLQLELDGLFWEANLEALpsppPFAALSEKRLYQSALYDEKSKlsssEVNDLKNE 1205

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1109 LVEENAKQTSEIL---AVQNLLQKQHVPLEQVEALKKSLNG----------TIENLKEELKSMQRCYEKEQQTVTKLHQL 1175
Cdd:COG5022   1206 LIALFSKIFSGWPrgdKLKKLISEGWVPTEYSTSLKGFNNLnkkfdtpasmSNEKLLSLLNSIDNLLSSYKLEEEVLPAT 1285

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1176 LENQ-KNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREvVDLSKYKATKS 1254
Cdd:COG5022   1286 INSLlQYINVGLFNALRTKASSLRWKSATEVNYNSEELDDWCREFEISDVDEELEELIQAVKVLQLLK-DDLNKLDELLD 1364

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1255 DLETQissLNEKLANLNRKYEevCEEVLHAKKKEISAKDEkellhfsieqeikdqKERCDKSLTTITELQRRIQESAKQI 1334
Cdd:COG5022   1365 ACYSL---NPAEIQNLKSRYD--PADKENNLPKEILKKIE---------------ALLIKQELQLSLEGKDETEVHLSEI 1424

                          570       580
                   ....*....|....*....|....*..
gi 1034591230 1335 EAKDNKITELLNDVERLKQALNGLSQL 1361
Cdd:COG5022   1425 FSEEKSLISLDRNSIYKEEVLSSLSAL 1451
PHA03095 PHA03095
ankyrin-like protein; Provisional
 170-246 9.53e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 50.02  E-value: 9.53e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  170 IQLLCDHGASVNAKDVDGRTPLVLATQMS---RPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCR-DAVEVLIKNGAD 245
Cdd:PHA03095    30 VRRLLAAGADVNFRGEYGKTPLHLYLHYSsekVKDIVRLLLEAGADVNAPERCGFTPLHLYLYNATTlDVIKLLIKAGAD 109


                   .
gi 1034591230  246 I 246
Cdd:PHA03095   110 V 110
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 513-1398 9.87e-06

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 50.17  E-value: 9.87e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  513 KQLEDALKDVQKRMYESEGKVKQMQThfLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEvgkLRNQIKQNEM 592
Cdd:pfam01576  155 KLLEERISEFTSNLAEEEEKAKSLSK--LKNKHEAMISDLEERLKKEEKGRQELEKAKRKLEGESTD---LQEQIAELQA 229

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  593 IVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPA-EKFENMKSSLSNEVnEKAKKLV 671
Cdd:pfam01576  230 QIAELRAQLAKKEEELQAALARLEEETAQKNNALKKIRELEAQISELQEDLESERAArNKAEKQRRDLGEEL-EALKTEL 308

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  672 EMEREHEKSLSEIRQlKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKvylDNKLLKE 751
Cdd:pfam01576  309 EDTLDTTAAQQELRS-KREQEVTELKKALEEETRSHEAQLQEMRQKHTQALEELTEQLEQAKRNKANLEK---AKQALES 384

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  752 QAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVppeKHEK 831
Cdd:pfam01576  385 ENAELQAELRTLQQAKQDSEHKRKKLEGQLQELQARLSESERQRAELAEKLSKLQSELESVSSLLNEAEGKNI---KLSK 461

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  832 EIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQyvpvkthEEVKMTLNDTLAKTNRELLDVKKKFE 911
Cdd:pfam01576  462 DVSSLESQLQDTQELLQEETRQKLNLSTRLRQLEDERNSLQEQLEEE-------EEAKRNVERQLSTLQAQLSDMKKKLE 534

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  912 DINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKV---QDSNAEILANYRKGQEEIVTLHAEIK 988
Cdd:pfam01576  535 EDAGTLEALEEGKKRLQRELEALTQQLEEKAAAYDKLEKTKNRLQQELDDLlvdLDHQRQLVSNLEKKQKKFDQMLAEEK 614

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  989 AqkkeldtiqecIKVKYApivsfEECER-KFKATEKELKD-QLSEQTQKYSVSEEEVKKNkqeNDKLKKEIFTL--QKDL 1064
Cdd:pfam01576  615 A-----------ISARYA-----EERDRaEAEAREKETRAlSLARALEEALEAKEELERT---NKQLRAEMEDLvsSKDD 675

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1065 RDKTVlieksHEME---RALSRKTDELNKQLKDLSQkytevknvkEKLVEENAKQTSEIlavqnllqkqhvpleQVEALK 1141
Cdd:pfam01576  676 VGKNV-----HELErskRALEQQVEEMKTQLEELED---------ELQATEDAKLRLEV---------------NMQALK 726

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1142 KSLNGTIENLKEELKsmqrcyEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEV 1221
Cdd:pfam01576  727 AQFERDLQARDEQGE------EKRRQLVKQVRELEAELEDERKQRAQAVAAKKKLELDLKELEAQIDAANKGREEAVKQL 800

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1222 SKLQSEVQNTKQALK--KLETREVVDLSKYKATKS-DLETQISSLNEKLANLNR-------KYEEVCEEVLHAKKKEISA 1291
Cdd:pfam01576  801 KKLQAQMKDLQRELEeaRASRDEILAQSKESEKKLkNLEAELLQLQEDLAASERarrqaqqERDELADEIASGASGKSAL 880

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1292 KDEKELLhfsiEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGL--------SQLTY 1363
Cdd:pfam01576  881 QDEKRRL----EARIAQLEEELEEEQSNTELLNDRLRKSTLQVEQLTTELAAERSTSQKSESARQQLerqnkelkAKLQE 956

                          890       900       910
                   ....*....|....*....|....*....|....*
gi 1034591230 1364 TSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQHQ 1398
Cdd:pfam01576  957 MEGTVKSKFKSSIAALEAKIAQLEEQLEQESRERQ 991
PRK01156 PRK01156
chromosome segregation protein; Provisional
 1023-1401 1.08e-05

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 50.29  E-value: 1.08e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1023 KELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEV 1102
Cdd:PRK01156   172 KDVIDMLRAEISNIDYLEEKLKSSNLELENIKKQIADDEKSHSITLKEIERLSIEYNNAMDDYNNLKSALNELSSLEDMK 251

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1103 KNVKEKLVEENAKQTSEILAVQNL--LQKQHVPLEQVEALKK--------SLNGTIENLKEELKSMQRCYEKEQQTVTKL 1172
Cdd:PRK01156   252 NRYESEIKTAESDLSMELEKNNYYkeLEERHMKIINDPVYKNrnyindyfKYKNDIENKKQILSNIDAEINKYHAIIKKL 331

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1173 HQL-------LENQKNSSVPLAEHLQIKEAFEKEVGIIKA--SLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREv 1243
Cdd:PRK01156   332 SVLqkdyndyIKKKSRYDDLNNQILELEGYEMDYNSYLKSieSLKKKIEEYSKNIERMSAFISEILKIQEIDPDAIKKE- 410

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1244 vdLSKYKATKSDLETQISSLNEKLANLNRKYEE---------------VCEEVLHAKKKEISAKD--------EKELLHF 1300
Cdd:PRK01156   411 --LNEINVKLQDISSKVSSLNQRIRALRENLDElsrnmemlngqsvcpVCGTTLGEEKSNHIINHynekksrlEEKIREI 488

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1301 SIEQEIKDQKERCDKSLTTITELQ--RRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLT--------------YT 1364
Cdd:PRK01156   489 EIEVKDIDEKIVDLKKRKEYLESEeiNKSINEYNKIESARADLEDIKIKINELKDKHDKYEEIKnrykslkledldskRT 568

                          410       420       430
                   ....*....|....*....|....*....|....*....
gi 1034591230 1365 SGNPTKRQSQLID--TLQHQVKSLEQQLADADRQHQEVI 1401
Cdd:PRK01156   569 SWLNALAVISLIDieTNRSRSNEIKKQLNDLESRLQEIE 607
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 510-742 1.29e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 49.38  E-value: 1.29e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  510 EQIKQLEDALKDVQKRMYESEGKVKQMQthflalkehltseaasgnhRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQ 589
Cdd:COG4942     20 DAAAEAEAELEQLQQEIAELEKELAALK-------------------KEEKALLKQLAALERRIAALARRIRALEQELAA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  590 NEMIVEEFKRDEGKLIEENKRLQKELSmcEMERekkgrkVTEMEGQAKELSAKLALSIPAEKFENMK---------SSLS 660
Cdd:COG4942     81 LEAELAELEKEIAELRAELEAQKEELA--ELLR------ALYRLGRQPPLALLLSPEDFLDAVRRLQylkylaparREQA 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  661 NEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKpeEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIE 740
Cdd:COG4942    153 EELRADLAELAALRAELEAERAELEALLAELEEERAALEALKA--ERQKLLARLEKELAELAAELAELQQEAEELEALIA 230


                   ..
gi 1034591230  741 KV 742
Cdd:COG4942    231 RL 232
COG5022 COG5022
Myosin heavy chain [General function prediction only];
965-1346 1.48e-05

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 49.69  E-value: 1.48e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  965 SNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIV-SFEECERKFKATEKELKDQLSEQTQK-------- 1035
Cdd:COG5022    804 SLLGSRKEYRSYLACIIKLQKTIKREKKLRETEEVEFSLKAEVLIqKFGRSLKAKKRFSLLKKETIYLQSAQrvelaerq 883

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1036 ---YSVSEEEVKKNKQENDKLKKEIF----TLQKDLRDKT-VLIEKSHEMERALS------------RKTDELNK----- 1090
Cdd:COG5022    884 lqeLKIDVKSISSLKLVNLELESEIIelkkSLSSDLIENLeFKTELIARLKKLLNnidleegpsieyVKLPELNKlheve 963

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1091 -QLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLngtiENLKEELKSMQRCYEKEQQTV 1169
Cdd:COG5022    964 sKLKETSEEYEDLLKKSTILVREGNKANSELKNFKKELAELSKQYGALQESTKQL----KELPVEVAELQSASKIISSES 1039

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1170 TKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQnkMEEVSKLQSEVQNTKQALKKLET---REVVDL 1246
Cdd:COG5022   1040 TELSILKPLQKLKGLLLLENNQLQARYKALKLRRENSLLDDKQLYQ--LESTENLLKTINVKDLEVTNRNLvkpANVLQF 1117

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1247 SKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTI-TELQR 1325
Cdd:COG5022   1118 IVAQMIKLNLLQEISKFLSQLVNTLEPVFQKLSVLQLELDGLFWEANLEALPSPPPFAALSEKRLYQSALYDEKsKLSSS 1197

                          410       420
                   ....*....|....*....|.
gi 1034591230 1326 RIQESAKQIEAKDNKITELLN 1346
Cdd:COG5022   1198 EVNDLKNELIALFSKIFSGWP 1218
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1079-1295 1.59e-05

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 49.06  E-value: 1.59e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1079 RALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQnllqkqhvplEQVEALKKSLNGTIENLKEELKSM 1158
Cdd:COG3883     26 SELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQ----------AEIAEAEAEIEERREELGERARAL 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1159 QRcyekEQQTVTKLHQLLENQKNSSVplaehlqikeafekevgIIKASLREKEEESQNK-MEEVSKLQSEVQNTKQALKK 1237
Cdd:COG3883     96 YR----SGGSVSYLDVLLGSESFSDF-----------------LDRLSALSKIADADADlLEELKADKAELEAKKAELEA 154

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1034591230 1238 LETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVcEEVLHAKKKEISAKDEK 1295
Cdd:COG3883    155 KLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAA-EAQLAELEAELAAAEAA 211
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
510-708 1.62e-05

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 49.53  E-value: 1.62e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  510 EQIKQLEDALKDVQKrmYEsegKVKQMQTHFLALKEHLTSEAAsgnHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQ 589
Cdd:COG4913    249 EQIELLEPIRELAER--YA---AARERLAELEYLRAALRLWFA---QRRLELLEAELEELRAELARLEAELERLEARLDA 320

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  590 NEMIVEEFKR----DEGKLIEenkRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPA------------EKFE 653
Cdd:COG4913    321 LREELDELEAqirgNGGDRLE---QLEREIERLERELEERERRRARLEALLAALGLPLPASAEEfaalraeaaallEALE 397

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034591230  654 NMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKR-------ELENVKAKLAQHVKPEEHE 708
Cdd:COG4913    398 EELEALEEALAEAEAALRDLRRELRELEAEIASLERrksnipaRLLALRDALAEALGLDEAE 459
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 509-821 1.64e-05

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 49.55  E-value: 1.64e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  509 DEQIKQLE-DALKDVQKRMYESEGKVKQMQTHFLALKEhLTSEAASGNHRLtEELKDQLKDLKVKYEGASAEVGKLRNQI 587
Cdd:COG1196    199 ERQLEPLErQAEKAERYRELKEELKELEAELLLLKLRE-LEAELEELEAEL-EELEAELEELEAELAELEAELEELRLEL 276

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  588 KQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALsipaekfenmkssLSNEVNEKA 667
Cdd:COG1196    277 EELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEE-------------LEEELEELE 343

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  668 KKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKP-EEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDN 746
Cdd:COG1196    344 EELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEElEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEEL 423

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034591230  747 KLLKEQAHNLTIEMKNHyvpLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLET 821
Cdd:COG1196    424 EELEEALAELEEEEEEE---EEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLL 495
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 736-1379 1.71e-05

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 49.66  E-value: 1.71e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  736 QKEIEKvyldNKLLKEQAHNLTIEMKNHYVPLKVSEDM---KKSHDAIID---DLNRKLLDVTQKYTEK--KLEMEKLLL 807
Cdd:TIGR01612 1506 AKAIEK----NKELFEQYKKDVTELLNKYSALAIKNKFaktKKDSEIIIKeikDAHKKFILEAEKSEQKikEIKKEKFRI 1581

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  808 ENDSLSKDVSRLETVFVPPEKHEKEIIALKsnIVELKKQLSELKKKCGEDQEKIHALT--SENTNLKKMMSNqyvpVKTH 885
Cdd:TIGR01612 1582 EDDAAKNDKSNKAAIDIQLSLENFENKFLK--ISDIKKKINDCLKETESIEKKISSFSidSQDTELKENGDN----LNSL 1655

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  886 EEVKMTLNDTlaKTNREllDVKKKFEDINQEFVKIKDKNEILKRNLE-NTQNQIKAEYISlaeHEAKMSSLSQSmrkVQD 964
Cdd:TIGR01612 1656 QEFLESLKDQ--KKNIE--DKKKELDELDSEIEKIEIDVDQHKKNYEiGIIEKIKEIAIA---NKEEIESIKEL---IEP 1725

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  965 SNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKD-QLSEQTQKYSVSEEEV 1043
Cdd:TIGR01612 1726 TIENLISSFNTNDLEGIDPNEKLEEYNTEIGDIYEEFIELYNIIAGCLETVSKEPITYDEIKNtRINAQNEFLKIIEIEK 1805

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1044 KKNKQENDKLKKEIFTLQKDLRDKTvlieksHEMERALSRKTDELNKQLKDLSQKYTEVKN-VKEKLVEENAKQTSEILA 1122
Cdd:TIGR01612 1806 KSKSYLDDIEAKEFDRIINHFKKKL------DHVNDKFTKEYSKINEGFDDISKSIENVKNsTDENLLFDILNKTKDAYA 1879

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1123 vqNLLQKQHVP--------LEQVEALKKSLNGTIEN------LKEELKSMQRCYEKEQQTVTKLHQLLENQKNSsvplae 1188
Cdd:TIGR01612 1880 --GIIGKKYYSykdeaekiFINISKLANSINIQIQNnsgidlFDNINIAILSSLDSEKEDTLKFIPSPEKEPEI------ 1951

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1189 HLQIKEAFEKEVGIIKAS--LREKEEESQNKMEEVSKLQSEVQNTKqalkklETREVVDLSKYKATK--SDLETQISSLN 1264
Cdd:TIGR01612 1952 YTKIRDSYDTLLDIFKKSqdLHKKEQDTLNIIFENQQLYEKIQASN------ELKDTLSDLKYKKEKilNDVKLLLHKFD 2025

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1265 E--KLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKIT 1342
Cdd:TIGR01612 2026 ElnKLSCDSQNYDTILELSKQDKIKEKIDNYEKEKEKFGIDFDVKAMEEKFDNDIKDIEKFENNYKHSEKDNHDFSEEKD 2105

                          650       660       670
                   ....*....|....*....|....*....|....*..
gi 1034591230 1343 ELLNDVERLKQALNGLSQLTYTSGNPTKRQSQLIDTL 1379
Cdd:TIGR01612 2106 NIIQSKKKLKELTEAFNTEIKIIEDKIIEKNDLIDKL 2142
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
 1052-1303 1.73e-05

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 49.16  E-value: 1.73e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1052 KLKK-EIFTLqKDLRDKTVliEKSHEMERA--LSRKTDELNKQLKDLSQKYTEVKNVKEKL--------VEENAKQTSEI 1120
Cdd:PRK05771     5 RMKKvLIVTL-KSYKDEVL--EALHELGVVhiEDLKEELSNERLRKLRSLLTKLSEALDKLrsylpklnPLREEKKKVSV 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1121 LAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSmqrcYEKEQQTVTKLH------QLLENQKNSSVPLAEhlqIKE 1194
Cdd:PRK05771    82 KSLEELIKDVEEELEKIEKEIKELEEEISELENEIKE----LEQEIERLEPWGnfdldlSLLLGFKYVSVFVGT---VPE 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1195 AFEKEVGIIKaSLREKEEESQNKMEE-----VSKLQSEVQNTkqALKKLETREVV---------DLSKYKATKSDLETQI 1260
Cdd:PRK05771   155 DKLEELKLES-DVENVEYISTDKGYVyvvvvVLKELSDEVEE--ELKKLGFERLEleeegtpseLIREIKEELEEIEKER 231

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*...
gi 1034591230 1261 SSLNEKLANLNRKYEE---VCEEVL--HAKKKEISAKDEKELLHFSIE 1303
Cdd:PRK05771   232 ESLLEELKELAKKYLEellALYEYLeiELERAEALSKFLKTDKTFAIE 279
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 97-224 2.03e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 49.24  E-value: 2.03e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230   97 SKGNLECLNAILI-HGVDITTSDTAGRNALHLAAKYGHALCLQKLLQ-----YNCPTEHADLQGRTALHDAAMADCPSSI 170
Cdd:cd22192     26 KENDVQAIKKLLKcPSCDLFQRGALGETALHVAALYDNLEAAVVLMEaapelVNEPMTSDLYQGETALHIAVVNQNLNLV 105

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034591230  171 QLLCDHGASVNAKDVD--------------GRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTAL 224
Cdd:cd22192    106 RELIARGADVVSPRATgtffrpgpknliyyGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVL 173
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 558-851 2.06e-05

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 49.16  E-value: 2.06e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  558 LTEELKDQLKDLK-----------VKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKG 626
Cdd:COG1196    194 ILGELERQLEPLErqaekaeryreLKEELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELR 273

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  627 RKVTEMEGQAKELSAKL-ALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQH---- 701
Cdd:COG1196    274 LELEELELELEEAQAEEyELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAeeel 353

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  702 ----VKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHyvplkvsEDMKKSH 777
Cdd:COG1196    354 eeaeAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERL-------EEELEEL 426

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034591230  778 DAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFvppEKHEKEIIALKSNIVELKKQLSELK 851
Cdd:COG1196    427 EEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEA---ALLEAALAELLEELAEAAARLLLLL 497
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1039-1273 2.17e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 48.61  E-value: 2.17e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1039 SEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTS 1118
Cdd:COG4942     18 QADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRA 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1119 EILAVQNLLQKQHV---PLEQVEALKKSLNGtiENLKEELKSMQRcyekeqqtvtkLHQLLENQKNSSVPLAEHLQIKEA 1195
Cdd:COG4942     98 ELEAQKEELAELLRalyRLGRQPPLALLLSP--EDFLDAVRRLQY-----------LKYLAPARREQAEELRADLAELAA 164

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034591230 1196 FEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRK 1273
Cdd:COG4942    165 LRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAER 242
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 459-940 2.73e-05

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 48.95  E-value: 2.73e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  459 NEILKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQL-------EDALKDVQKRMYESEG 531
Cdd:pfam05483  189 NNNIEKMILAFEELRVQAENARLEMHFKLKEDHEKIQHLEEEYKKEINDKEKQVSLLliqitekENKMKDLTFLLEESRD 268

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  532 KVKQMQ----------THFLALKEHLTSE----------AASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNE 591
Cdd:pfam05483  269 KANQLEektklqdenlKELIEKKDHLTKEledikmslqrSMSTQKALEEDLQIATKTICQLTEEKEAQMEELNKAKAAHS 348

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  592 MIVEEFKRDEGKLIE----ENKRLQK---ELSMCEMEREKKGRKVTEMEG--QAKELSAKLALSIPAEKfenmkSSLSNE 662
Cdd:pfam05483  349 FVVTEFEATTCSLEEllrtEQQRLEKnedQLKIITMELQKKSSELEEMTKfkNNKEVELEELKKILAED-----EKLLDE 423

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  663 vNEKAKKLVEMEREHEKSLSEIRQLK-RELENVKAKLAQHVKPEEHeqvksrLEQKSGELGKKITELTLKNQTLQKEIEK 741
Cdd:pfam05483  424 -KKQFEKIAEELKGKEQELIFLLQAReKEIHDLEIQLTAIKTSEEH------YLKEVEDLKTELEKEKLKNIELTAHCDK 496

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  742 VYLDNKLLKEQAHNLTIEMKNHYVPLKvseDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLET 821
Cdd:pfam05483  497 LLLENKELTQEASDMTLELKKHQEDII---NCKKQEERMLKQIENLEEKEMNLRDELESVREEFIQKGDEVKCKLDKSEE 573

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  822 vfvPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEevkmtlnDTLAKTNR 901
Cdd:pfam05483  574 ---NARSIEYEVLKKEKQMKILENKCNNLKKQIENKNKNIEELHQENKALKKKGSAENKQLNAYE-------IKVNKLEL 643

                          490       500       510
                   ....*....|....*....|....*....|....*....
gi 1034591230  902 ELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKA 940
Cdd:pfam05483  644 ELASAKQKFEEIIDNYQKEIEDKKISEEKLLEEVEKAKA 682
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 269-913 3.53e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 48.51  E-value: 3.53e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  269 LTLLKTASENTNKGRELWKKGPSLQQRNLTHMQDEVNVKSHQREHQN--IQDLEIENEDLKERLRKIQQEQRILLDKVng 346
Cdd:TIGR02168  353 LESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNneIERLEARLERLEDRRERLQQEIEELLKKL-- 430

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  347 LQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFESDHLGSGSHFSNRKEDMLLKQGQmymads 426
Cdd:TIGR02168  431 EEAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGF------ 504

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  427 qctSPGIPAHMQSRSMLRPLELSLPSQTSYSENeiLKKELEA----------MRTFcESAKQDRLKLQNELAHKVAECkA 496
Cdd:TIGR02168  505 ---SEGVKALLKNQSGLSGILGVLSELISVDEG--YEAAIEAalggrlqavvVENL-NAAKKAIAFLKQNELGRVTFL-P 577

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  497 LALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKeHLTSEAASGNHRLTEELKDQ----LKDLKVK 572
Cdd:TIGR02168  578 LDSIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSYLLGGV-LVVDDLDNALELAKKLRPGYrivtLDGDLVR 656

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  573 YEG--------ASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLA 644
Cdd:TIGR02168  657 PGGvitggsakTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLA 736

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  645 -LSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVkpEEHEQVKSRLEQKSGE--- 720
Cdd:TIGR02168  737 rLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLK--EELKALREALDELRAEltl 814

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  721 LGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMknhyvpLKVSEDMKKSHDAiIDDLNRKLLDVTQKYTEKKL 800
Cdd:TIGR02168  815 LNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDI------ESLAAEIEELEEL-IEELESELEALLNERASLEE 887

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  801 EMEKLLLENDSLSKDVSRLEtvfvppekhekeiialkSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQY- 879
Cdd:TIGR02168  888 ALALLRSELEELSEELRELE-----------------SKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERLSEEYs 950

                          650       660       670
                   ....*....|....*....|....*....|....
gi 1034591230  880 VPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDI 913
Cdd:TIGR02168  951 LTLEEAEALENKIEDDEEEARRRLKRLENKIKEL 984
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 768-1141 3.61e-05

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 48.47  E-value: 3.61e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  768 KVSEDMKKSHDAIIDDLNRKLLDVTQKYTeKKLEMEKLLLENDSLSKDVSRLETVFvppEKHEKEIIALKSNIVELKKQL 847
Cdd:NF033838    73 EIQKSLDKRKHTQNVALNKKLSDIKTEYL-YELNVLKEKSEAELTSKTKKELDAAF---EQFKKDTLEPGKKVAEATKKV 148

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  848 SELKKKCGEDQEKIHALTSENTnlkkmmsnqyvpVKTHEEVKMTLNDTLAKTNRELLDVKKKF----EDINQEFVKIKDK 923
Cdd:NF033838   149 EEAEKKAKDQKEEDRRNYPTNT------------YKTLELEIAESDVEVKKAELELVKEEAKEprdeEKIKQAKAKVESK 216

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  924 NEILKRnLENTQNQIKAeyislAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKV 1003
Cdd:NF033838   217 KAEATR-LEKIKTDREK-----AEEEAKRRADAKLKEAVEKNVATSEQDKPKRRAKRGVLGEPATPDKKENDAKSSDSSV 290

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1004 --------KYAPIVSFEECERKFKATEKELKDQLSEQTQKY----------SVSEEEVKKNKQENDKLKKEiftlQKDLR 1065
Cdd:NF033838   291 geetlpspSLKPEKKVAEAEKKVEEAKKKAKDQKEEDRRNYptntyktlelEIAESDVKVKEAELELVKEE----AKEPR 366

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1066 DKTVLIEKSHEMERALSRKT------DELNKQLKDLSQKYTEVKNVKEKLVEEnaKQTSEILAVQNLLQKQHVPLEQVEA 1139
Cdd:NF033838   367 NEEKIKQAKAKVESKKAEATrlekikTDRKKAEEEAKRKAAEEDKVKEKPAEQ--PQPAPAPQPEKPAPKPEKPAEQPKA 444


                   ..
gi 1034591230 1140 LK 1141
Cdd:NF033838   445 EK 446
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 600-1311 4.75e-05

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 48.12  E-value: 4.75e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  600 DEGKLIEENKRLQKELSMCE-MEREKKGRKVTEMEGQAKELSaklalSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHE 678
Cdd:TIGR01612  694 DKAKLDDLKSKIDKEYDKIQnMETATVELHLSNIENKKNELL-----DIIVEIKKHIHGEINKDLNKILEDFKNKEKELS 768

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  679 KSLSEIRQLKRELENVKAKLAQhVKPEEHEQ--VKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNL 756
Cdd:TIGR01612  769 NKINDYAKEKDELNKYKSKISE-IKNHYNDQinIDNIKDEDAKQNYDKSKEYIKTISIKEDEIFKIINEMKFMKDDFLNK 847

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  757 TiemkNHYVPLK--VSEDMKKSHDAIIDDLNRKLLDVTQkytEKKLEMEKLLLENDSLSKDVSrletvfvppekheKEII 834
Cdd:TIGR01612  848 V----DKFINFEnnCKEKIDSEHEQFAELTNKIKAEISD---DKLNDYEKKFNDSKSLINEIN-------------KSIE 907

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  835 ALKSNIVELKKqLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLND----TLAKTNRELLDVKKK- 909
Cdd:TIGR01612  908 EEYQNINTLKK-VDEYIKICENTKESIEKFHNKQNILKEILNKNIDTIKESNLIEKSYKDkfdnTLIDKINELDKAFKDa 986

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  910 ----FEDINQEFVK-IKDKNEILKRNLENTQnqikaeYISLAEHEAKMSSLSQsmrKVQDSNAEI----LANYRKGQEEI 980
Cdd:TIGR01612  987 slndYEAKNNELIKyFNDLKANLGKNKENML------YHQFDEKEKATNDIEQ---KIEDANKNIpnieIAIHTSIYNII 1057

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  981 VTLHAEIKAQKKELDTiqECIKVKYAPIVSFEECERKFK---------------ATE-KELKDQLSEQTQK--YSVSEEE 1042
Cdd:TIGR01612 1058 DEIEKEIGKNIELLNK--EILEEAEINITNFNEIKEKLKhynfddfgkeenikyADEiNKIKDDIKNLDQKidHHIKALE 1135

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1043 VKKNKQEN--DKLKKEIFTLQkDLRDKTVLIEKSHEMERALSRKTDELNKQlkdlSQKYTEVKNVKEKLVEENAKQTS-E 1119
Cdd:TIGR01612 1136 EIKKKSENyiDEIKAQINDLE-DVADKAISNDDPEEIEKKIENIVTKIDKK----KNIYDEIKKLLNEIAEIEKDKTSlE 1210

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1120 ILAVQNLLQKQHVP---LEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLE------------------- 1177
Cdd:TIGR01612 1211 EVKGINLSYGKNLGklfLEKIDEEKKKSEHMIKAMEAYIEDLDEIKEKSPEIENEMGIEMDikaemetfnishdddkdhh 1290

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1178 -----NQKNSSVPLAEHLQIKEAFEKEVGI--IKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDlsKYK 1250
Cdd:TIGR01612 1291 iiskkHDENISDIREKSLKIIEDFSEESDIndIKKELQKNLLDAQKHNSDINLYLNEIANIYNILKLNKIKKIID--EVK 1368

                          730       740       750       760       770       780
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034591230 1251 ATKSDLETQISSLNEKLANLNRKYEEVCEEVlhaKKKEISAKDEKELLHFSIEQEIKDQKE 1311
Cdd:TIGR01612 1369 EYTKEIEENNKNIKDELDKSEKLIKKIKDDI---NLEECKSKIESTLDDKDIDECIKKIKE 1426
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
502-700 5.51e-05

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 47.70  E-value: 5.51e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  502 ERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQthflalKEH----LTSEAASGNHRLTeELKDQLKDLKVKYEGAS 577
Cdd:COG3206    167 ELRREEARKALEFLEEQLPELRKELEEAEAALEEFR------QKNglvdLSEEAKLLLQQLS-ELESQLAEARAELAEAE 239

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  578 AEVGKLRNQIKQNEMIVEEFKRDegkliEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLAlsipaekfeNMKS 657
Cdd:COG3206    240 ARLAALRAQLGSGPDALPELLQS-----PVIQQLRAQLAELEAELAELSARYTPNHPDVIALRAQIA---------ALRA 305

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 1034591230  658 SLSNEVnekAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQ 700
Cdd:COG3206    306 QLQQEA---QRILASLEAELEALQAREASLQAQLAQLEARLAE 345
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1203-1429 7.24e-05

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 47.32  E-value: 7.24e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1203 IKASLREKEEESQNKM----EEVSKLQSEVQNTKQALKKLETRE-VVDLSkykATKSDLETQISSLNEKLANLNRKYEEV 1277
Cdd:COG3206    162 LEQNLELRREEARKALefleEQLPELRKELEEAEAALEEFRQKNgLVDLS---EEAKLLLQQLSELESQLAEARAELAEA 238

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1278 ceEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNG 1357
Cdd:COG3206    239 --EARLAALRAQLGSGPDALPELLQSPVIQQLRAQLAELEAELAELSARYTPNHPDVIALRAQIAALRAQLQQEAQRILA 316

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034591230 1358 LSQLTYTSGNPTKRQ-SQLIDTLQHQVKSL---EQQLADADRQHQEVIAIYRTHLLSAAQGHMDEDVQEALLQIIQ 1429
Cdd:COG3206    317 SLEAELEALQAREASlQAQLAQLEARLAELpelEAELRRLEREVEVARELYESLLQRLEEARLAEALTVGNVRVID 392
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 967-1429 7.35e-05

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 47.66  E-value: 7.35e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  967 AEILANYrKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERK--------FKATEKELKDQLSE--QTQKY 1036
Cdd:TIGR00618  166 KELLMNL-FPLDQYTQLALMEFAKKKSLHGKAELLTLRSQLLTLCTPCMPDtyherkqvLEKELKHLREALQQtqQSHAY 244

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1037 SVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEmERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQ 1116
Cdd:TIGR00618  245 LTQKREAQEEQLKKQQLLKQLRARIEELRAQEAVLEETQE-RINRARKAAPLAAHIKAVTQIEQQAQRIHTELQSKMRSR 323

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1117 TSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQT-----VTKLHQLLENQKNSSVPLAEHLQ 1191
Cdd:TIGR00618  324 AKLLMKRAAHVKQQSSIEEQRRLLQTLHSQEIHIRDAHEVATSIREISCQQHtltqhIHTLQQQKTTLTQKLQSLCKELD 403

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1192 IKEAFEKEVGIIKASLR---------EKEEESQNKMEEVSKLQSEVQNTKQALKKLE-------TREVVDLSKYKATKSD 1255
Cdd:TIGR00618  404 ILQREQATIDTRTSAFRdlqgqlahaKKQQELQQRYAELCAAAITCTAQCEKLEKIHlqesaqsLKEREQQLQTKEQIHL 483

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1256 LETQISSLNEKLANLNRKYE-EVCEEVLH--AKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAK 1332
Cdd:TIGR00618  484 QETRKKAVVLARLLELQEEPcPLCGSCIHpnPARQDIDNPGPLTRRMQRGEQTYAQLETSEEDVYHQLTSERKQRASLKE 563

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1333 QIEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTKRQSQLIDTL---------QHQVKSLEQQLADADRQHQEVIAI 1403
Cdd:TIGR00618  564 QMQEIQQSFSILTQCDNRSKEDIPNLQNITVRLQDLTEKLSEAEDMLaceqhallrKLQPEQDLQDVRLHLQQCSQELAL 643

                          490       500
                   ....*....|....*....|....*.
gi 1034591230 1404 YRTHLLSAAQGHMDEDVQEALLQIIQ 1429
Cdd:TIGR00618  644 KLTALHALQLTLTQERVREHALSIRV 669
46 PHA02562
endonuclease subunit; Provisional
 509-719 8.41e-05

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 46.93  E-value: 8.41e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  509 DEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASgNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIK 588
Cdd:PHA02562   187 DMKIDHIQQQIKTYNKNIEEQRKKNGENIARKQNKYDELVEEAKT-IKAEIEELTDELLNLVMDIEDPSAALNKLNTAAA 265

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  589 QNEMIVEEFKRDE-----------------------GKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKlal 645
Cdd:PHA02562   266 KIKSKIEQFQKVIkmyekggvcptctqqisegpdriTKIKDKLKELQHSLEKLDTAIDELEEIMDEFNEQSKKLLEL--- 342

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034591230  646 sipAEKFENMKSSLSNEVNEKAKKLVEMER---EHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSG 719
Cdd:PHA02562   343 ---KNKISTNKQSLITLVDKAKKVKAAIEElqaEFVDNAEELAKLQDELDKIVKTKSELVKEKYHRGIVTDLLKDSG 416
Ank_5 pfam13857
Ankyrin repeats (many copies);
73-128 8.68e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 41.56  E-value: 8.68e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1034591230   73 ILAKKGVNPGKLDVEGRSVFHVVTSKGNLECLNAILIHGVDITTSDTAGRNALHLA 128
Cdd:pfam13857    1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 252-1084 8.72e-05

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 47.02  E-value: 8.72e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  252 LGHDSSYYARIGDNLDILTLLKTASENTNKGRELWKKGPSLQQRNLTHMQDEVNVKSHQREHQNIQDLEIENEDLKERL- 330
Cdd:pfam05483    1 AGGDSNFFKSFNKCTEDDFEFPFAKSNLSKNGENIDSDPAFQKLNFLPMLEQVANSGDCHYQEGLKDSDFENSEGLSRLy 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  331 RKIQQEqrilldkvnglqlqlneevmvADDLESEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFEsdhlgsgshFSNR 410
Cdd:pfam05483   81 SKLYKE---------------------AEKIKKWKVSIEAELKQKENKLQENRKIIEAQRKAIQELQ---------FENE 130

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  411 KEDMLLKQGQMYMADSqctspgipahMQSRSMLRPLELSLPSQTSYSENEILKKELEAmrtfcESAKQDRLKLQNELAHK 490
Cdd:pfam05483  131 KVSLKLEEEIQENKDL----------IKENNATRHLCNLLKETCARSAEKTKKYEYER-----EETRQVYMDLNNNIEKM 195

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  491 VAECKALALECERVKEDSDEQIKQLEDALKDVQKRmYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLK 570
Cdd:pfam05483  196 ILAFEELRVQAENARLEMHFKLKEDHEKIQHLEEE-YKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKANQLE 274

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  571 VKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKEL-----SMCEMEREKKgrkvTEMEGQAKelsAKLAL 645
Cdd:pfam05483  275 EKTKLQDENLKELIEKKDHLTKELEDIKMSLQRSMSTQKALEEDLqiatkTICQLTEEKE----AQMEELNK---AKAAH 347

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  646 SIPAEKFENMKSSLSN---------EVNEKAKKLVEMEREHEKS-LSEIRQLKR----ELENVKAKLAQHVKPEEHeqvK 711
Cdd:pfam05483  348 SFVVTEFEATTCSLEEllrteqqrlEKNEDQLKIITMELQKKSSeLEEMTKFKNnkevELEELKKILAEDEKLLDE---K 424

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  712 SRLEQKSGELGKKITELTLKNQTLQKEIekvyldnkllkeqaHNLTIEmknhyvpLKVSEDMKKSHDAIIDDLNRKLLDV 791
Cdd:pfam05483  425 KQFEKIAEELKGKEQELIFLLQAREKEI--------------HDLEIQ-------LTAIKTSEEHYLKEVEDLKTELEKE 483

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  792 TQKYTEKKLEMEKLLLENDSLSKDVSRLetvFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSE---- 867
Cdd:pfam05483  484 KLKNIELTAHCDKLLLENKELTQEASDM---TLELKKHQEDIINCKKQEERMLKQIENLEEKEMNLRDELESVREEfiqk 560

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  868 NTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAE 947
Cdd:pfam05483  561 GDEVKCKLDKSEENARSIEYEVLKKEKQMKILENKCNNLKKQIENKNKNIEELHQENKALKKKGSAENKQLNAYEIKVNK 640

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  948 HEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKyapivsfeeCERKFK---ATEKE 1024
Cdd:pfam05483  641 LELELASAKQKFEEIIDNYQKEIEDKKISEEKLLEEVEKAKAIADEAVKLQKEIDKR---------CQHKIAemvALMEK 711

                          810       820       830       840       850       860
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1025 LKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRK 1084
Cdd:pfam05483  712 HKHQYDKIIEERDSELGLYKNKEQEQSSAKAALEIELSNIKAELLSLKKQLEIEKEEKEK 771
CagA_N pfam18971
CagA protein; The Helicobacter pylori type IV secretion effector CagA is a major bacterial ...
 927-1178 1.14e-04

CagA protein; The Helicobacter pylori type IV secretion effector CagA is a major bacterial virulence determinant and critical for gastric carcinogenesis. X-ray crystallographic analysis of the N-terminal CagA fragment (residues 1-876) revealed that the region has a structure comprised of three discrete domains. Domain I constitutes a mobile CagA N terminus, while Domain II tethers CagA to the plasma membrane by interacting with membrane phosphatidylserine. Domain III interacts intramolecularly with the intrinsically disordered C-terminal region, and this interaction potentiates the pathogenic scaffold/hub function of CagA.


Pssm-ID: 408741 [Multi-domain]  Cd Length: 876  Bit Score: 46.69  E-value: 1.14e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  927 LKRNLENtqnQIKAEYISLAEHEAKMSSLSQSMRKVqdsnAEILANYRKGQEEIVTL--HAEIKAQKKELdtiqecikvk 1004
Cdd:pfam18971  557 VRRNLEN---KLTAKGLSLQEANKLIKDFLSSNKEL----AGKALNFNKAVAEAKSTgnYDEVKKAQKDL---------- 619

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1005 yapivsfEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQendklKKEIFTL--QKDLRDKTVL--IEKSHEMERA 1080
Cdd:pfam18971  620 -------EKSLRKREHLEKEVEKKLESKSGNKNKMEAKAQANSQ-----KDEIFALinKEANRDARAIayTQNLKGIKRE 687

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1081 LSRKTDELNKQLKDLSQKYTEVKNVKEKlveENAKQTSEILAVQNLLQKQHVPLEQVEalkkslngTIENLKEELKSMQR 1160
Cdd:pfam18971  688 LSDKLEKISKDLKDFSKSFDEFKNGKNK---DFSKAEETLKALKGSVKDLGINPEWIS--------KVENLNAALNEFKN 756

                          250
                   ....*....|....*...
gi 1034591230 1161 CYEKEQQTVTKLHQLLEN 1178
Cdd:pfam18971  757 GKNKDFSKVTQAKSDLEN 774
Ank_5 pfam13857
Ankyrin repeats (many copies);
206-253 1.25e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 41.18  E-value: 1.25e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1034591230  206 LIDRG-ADVNSRDKQNRTALMLGCEYGCRDAVEVLIKNGADISLLDALG 253
Cdd:pfam13857    1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEG 49
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 882-1392 1.39e-04

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 46.71  E-value: 1.39e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  882 VKTHEEVKMTLNDTLAKTNRElldvKKKFEDINQEFVKIKDKNEILKRNLENTQNQikaeyislaeHEAKMSSLSQSMRK 961
Cdd:pfam01576  133 IKKLEEDILLLEDQNSKLSKE----RKLLEERISEFTSNLAEEEEKAKSLSKLKNK----------HEAMISDLEERLKK 198

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  962 VQDSNAEILANYRKGQEEIVTLHAEIKAQKKELdtiqecikvkyapivsfEECERKFKATEKELKDQLSEQTQKYSVSEE 1041
Cdd:pfam01576  199 EEKGRQELEKAKRKLEGESTDLQEQIAELQAQI-----------------AELRAQLAKKEEELQAALARLEEETAQKNN 261

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1042 EVKKNKQendkLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDL-----------SQKYTEVKNVKEKLV 1110
Cdd:pfam01576  262 ALKKIRE----LEAQISELQEDLESERAARNKAEKQRRDLGEELEALKTELEDTldttaaqqelrSKREQEVTELKKALE 337

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1111 EENAKQTSEilaVQNLLQKQHVPLEQ--------------VEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLH-QL 1175
Cdd:pfam01576  338 EETRSHEAQ---LQEMRQKHTQALEElteqleqakrnkanLEKAKQALESENAELQAELRTLQQAKQDSEHKRKKLEgQL 414

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1176 LENQKNSSVPLAEHLQIKEAFEK---EVGIIKASLREKEEESQNKMEEVSKLQSEVQNTkQALKKLETREvvdlskykat 1252
Cdd:pfam01576  415 QELQARLSESERQRAELAEKLSKlqsELESVSSLLNEAEGKNIKLSKDVSSLESQLQDT-QELLQEETRQ---------- 483

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1253 KSDLETQISSLNEKLANLNRKYEEvceevlhakkkEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAK 1332
Cdd:pfam01576  484 KLNLSTRLRQLEDERNSLQEQLEE-----------EEEAKRNVERQLSTLQAQLSDMKKKLEEDAGTLEALEEGKKRLQR 552

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1333 QIEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLAD 1392
Cdd:pfam01576  553 ELEALTQQLEEKAAAYDKLEKTKNRLQQELDDLLVDLDHQRQLVSNLEKKQKKFDQMLAE 612
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 126-206 1.64e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 46.04  E-value: 1.64e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  126 HLAAKyGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQL 205
Cdd:PTZ00322    88 QLAAS-GDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQL 166


                   .
gi 1034591230  206 L 206
Cdd:PTZ00322   167 L 167
CCDC22 pfam05667
Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 ...
 1010-1359 1.67e-04

Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 (CCDC22) is involved in regulation of NF-kappa-B signalling; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. It is part of the OMMD/CCDC22/CCDC93 (CCC) complex, which interacts with the multisubunit WASH complex required for endosomal deposition of F-actin and cargo trafficking in conjunction with the retromer. This entry also includes CCDC22 homologs from animals and plants.


Pssm-ID: 461708 [Multi-domain]  Cd Length: 600  Bit Score: 46.17  E-value: 1.67e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1010 SFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQEndklkkeifTLQKDLRDK-TVLIEKSHEMERALSRKTDEL 1088
Cdd:pfam05667  207 SLLERNAAELAAAQEWEEEWNSQGLASRLTPEEYRKRKRT---------KLLKRIAEQlRSAALAGTEATSGASRSAQDL 277

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1089 NKQLKDLSQKYTEVKNV--------KEKLV--EENAKQTSEILAV----QNLLQKQHVPLEQVEALKKSLNGTIENLKEE 1154
Cdd:pfam05667  278 AELLSSFSGSSTTDTGLtkgsrfthTEKLQftNEAPAATSSPPTKveteEELQQQREEELEELQEQLEDLESSIQELEKE 357

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1155 LKSMQrcyekeqQTVTKLHQLLENQKNSSVPLAEHLQIKEafeKEVGIIkaslrekeEESQNKMEevsKLQSEVQNTKQA 1234
Cdd:pfam05667  358 IKKLE-------SSIKQVEEELEELKEQNEELEKQYKVKK---KTLDLL--------PDAEENIA---KLQALVDASAQR 416

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1235 LKKLEtrevvdlSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEV--LHAKKKEISAK-DEKELLHfsieQEIKDQKE 1311
Cdd:pfam05667  417 LVELA-------GQWEKHRVPLIEEYRALKEAKSNKEDESQRKLEEIkeLREKIKEVAEEaKQKEELY----KQLVAEYE 485

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*...
gi 1034591230 1312 RCDKSlTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLS 1359
Cdd:pfam05667  486 RLPKD-VSRSAYTRRILEIVKNIKKQKEEITKILSDTKSLQKEINSLT 532
Ank_2 pfam12796
Ankyrin repeats (3 copies);
27-118 1.74e-04

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 42.03  E-value: 1.74e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230   27 LMKLAQKGegNLECNWKISDHAADWNKYDDR----LMKAAERGDVEKVTSILAKKGVNpgkLDVEGRSVFHVVTSKGNLE 102
Cdd:pfam12796    1 LHLAAKNG--NLELVKLLLENGADANLQDKNgrtaLHLAAKNGHLEIVKLLLEHADVN---LKDNGRTALHYAARSGHLE 75

                           90
                   ....*....|....*.
gi 1034591230  103 CLNAILIHGVDITTSD 118
Cdd:pfam12796   76 IVKLLLEKGADINVKD 91
PTZ00440 PTZ00440
reticulocyte binding protein 2-like protein; Provisional
 846-1351 1.79e-04

reticulocyte binding protein 2-like protein; Provisional


Pssm-ID: 240419 [Multi-domain]  Cd Length: 2722  Bit Score: 46.36  E-value: 1.79e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  846 QLSELKKKCGEDQEKIHALTSENTNLKKMMSNqyVPVKTHEEVkMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNE 925
Cdd:PTZ00440   985 KLDKEKDEWEHFKSEIDKLNVNYNILNKKIDD--LIKKQHDDI-IELIDKLIKEKGKEIEEKVDQYISLLEKMKTKLSSF 1061

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  926 ILKRNLENTQNQIKAEYISLAEHeaKMSSLsqsMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQ-------KKELDTIQ 998
Cdd:PTZ00440  1062 HFNIDIKKYKNPKIKEEIKLLEE--KVEAL---LKKIDENKNKLIEIKNKSHEHVVNADKEKNKQtehynkkKKSLEKIY 1136

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  999 ECIKVKYAPIVSFEECERKFKATEK-----------ELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDlrdk 1067
Cdd:PTZ00440  1137 KQMEKTLKELENMNLEDITLNEVNEieieyerilidHIVEQINNEAKKSKTIMEEIESYKKDIDQVKKNMSKERND---- 1212

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1068 tvlieksHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKlvEENAKQTSEILAVQNLLqkqHVPLEQVealkKSLNGT 1147
Cdd:PTZ00440  1213 -------HLTTFEYNAYYDKATASYENIEELTTEAKGLKGE--ANRSTNVDELKEIKLQV---FSYLQQV----IKENNK 1276

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1148 IENLKEELKSMqrcyeKEQQTVTKLHQLLENQKNSSVPLAEH-LQIKEAFEKEVGIIKASLR--EKEEESQNKM---EEV 1221
Cdd:PTZ00440  1277 MENALHEIKNM-----YEFLISIDSEKILKEILNSTKKAEEFsNDAKKELEKTDNLIKQVEAkiEQAKEHKNKIygsLED 1351

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1222 SKLQSEVQNTKQALKKL-ETREVVD--LSKYKATKSDLETQISSLNEKLANLNrkyeevceevLHAKKKEISAKDEKEll 1298
Cdd:PTZ00440  1352 KQIDDEIKKIEQIKEEIsNKRKEINkyLSNIKSNKEKCDLHVRNASRGKDKID----------FLNKHEAIEPSNSKE-- 1419

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1034591230 1299 hFSIeQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERL 1351
Cdd:PTZ00440  1420 -VNI-IKITDNINKCKQYSNEAMETENKADENNDSIIKYEKEITNILNNSSIL 1470
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 204-272 1.98e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 46.04  E-value: 1.98e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034591230  204 QLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLIKNGADISLLDALGHDSSYYARIGDNLDILTLL 272
Cdd:PTZ00322    99 RILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLL 167
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1090-1270 2.00e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 44.53  E-value: 2.00e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1090 KQLKDLSQKYTE---VKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSmqrcYEKEQ 1166
Cdd:COG1579      7 RALLDLQELDSEldrLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKK----YEEQL 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1167 QTVTKLHQLlenqknssvplaehlqikEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDL 1246
Cdd:COG1579     83 GNVRNNKEY------------------EALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKK 144

                          170       180
                   ....*....|....*....|....
gi 1034591230 1247 SKYKATKSDLETQISSLNEKLANL 1270
Cdd:COG1579    145 AELDEELAELEAELEELEAEREEL 168
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
1231-1355 2.04e-04

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 46.00  E-value: 2.04e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1231 TKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLnRKYEEVCEEVLHAKKKEIsAKDEKELLHFSIEQEIKDQK 1310
Cdd:COG2433    386 IEKELPEEEPEAEREKEHEERELTEEEEEIRRLEEQVERL-EAEVEELEAELEEKDERI-ERLERELSEARSEERREIRK 463

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1034591230 1311 ERcdksltTITELQRRIQESAKQIEAKDNKITELLNDVERLKQAL 1355
Cdd:COG2433    464 DR------EISRLDREIERLERELEEERERIEELKRKLERLKELW 502
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 186-218 2.17e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 39.97  E-value: 2.17e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1034591230  186 DGRTPLVLA-TQMSRPTICQLLIDRGADVNSRDK 218
Cdd:pfam00023    1 DGNTPLHLAaGRRGNLEIVKLLLSKGADVNARDK 34
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 1011-1374 2.31e-04

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 45.73  E-value: 2.31e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1011 FEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNK 1090
Cdd:pfam02463  165 SRLKRKKKEALKKLIEETENLAELIIDLEELKLQELKLKEQAKKALEYYQLKEKLELEEEYLLYLDYLKLNEERIDLLQE 244

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1091 QLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVT 1170
Cdd:pfam02463  245 LLRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKEKK 324

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1171 KLHQLLENQKNSSVPLaehlqikEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYK 1250
Cdd:pfam02463  325 KAEKELKKEKEEIEEL-------EKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEEL 397

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1251 ATKSDLETQISSLNEklanlNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQES 1330
Cdd:pfam02463  398 ELKSEEEKEAQLLLE-----LARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLLKDELELKKSED 472

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....
gi 1034591230 1331 AKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTKRQSQ 1374
Cdd:pfam02463  473 LLKETQLVKLQEQLELLLSRQKLEERSQKESKARSGLKVLLALI 516
Ank_4 pfam13637
Ankyrin repeats (many copies);
121-173 2.34e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 40.34  E-value: 2.34e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1034591230  121 GRNALHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADCPSSIQLL 173
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
515-716 2.60e-04

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 45.53  E-value: 2.60e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  515 LEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTE------ELKDQLKDLKVKYEGASAEVGKLRnQIK 588
Cdd:COG4717     47 LLERLEKEADELFKPQGRKPELNLKELKELEEELKEAEEKEEEYAElqeeleELEEELEELEAELEELREELEKLE-KLL 125

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  589 QNEMIVEEFKRDEGKLIEENKRLQkELSMCEMEREKKGRKVTEMEGQAKELSAKLAlsipaEKFENMKSSLSNEVNEKAK 668
Cdd:COG4717    126 QLLPLYQELEALEAELAELPERLE-ELEERLEELRELEEELEELEAELAELQEELE-----ELLEQLSLATEEELQDLAE 199

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*...
gi 1034591230  669 KLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQ 716
Cdd:COG4717    200 ELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERLKE 247
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1070-1358 2.66e-04

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 45.44  E-value: 2.66e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1070 LIEKSHEMERALSRKT--DELNKQLKDLSQKYTEVKNVKEKLvEENAKQTSEIlavQNLLQKQHVPLEQVEALKKSLNGT 1147
Cdd:PRK03918   140 ILESDESREKVVRQILglDDYENAYKNLGEVIKEIKRRIERL-EKFIKRTENI---EELIKEKEKELEEVLREINEISSE 215

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1148 IENLKEELKSMqrcyEKEQQTVTKLHQLLENQKNSsvplaehlqiKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSE 1227
Cdd:PRK03918   216 LPELREELEKL----EKEVKELEELKEEIEELEKE----------LESLEGSKRKLEEKIRELEERIEELKKEIEELEEK 281

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1228 VQNTKQ---------ALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEevLHAKKKEIS---AKDEK 1295
Cdd:PRK03918   282 VKELKElkekaeeyiKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKELEEKEERLEE--LKKKLKELEkrlEELEE 359

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034591230 1296 ELLHFSIEQEIKDQKERCDKSLT--TITELQRRIQESAK---QIEAKDNKIT----ELLNDVERLKQALNGL 1358
Cdd:PRK03918   360 RHELYEEAKAKKEELERLKKRLTglTPEKLEKELEELEKakeEIEEEISKITarigELKKEIKELKKAIEEL 431
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1079-1340 2.76e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 45.14  E-value: 2.76e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1079 RALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSM 1158
Cdd:COG4942     23 AEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQ 102

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1159 QRCYEKeqqtvtklhQLLENQKNSSVPLAEHLQIKEAFEkEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKkl 1238
Cdd:COG4942    103 KEELAE---------LLRALYRLGRQPPLALLLSPEDFL-DAVRRLQYLKYLAPARREQAEELRADLAELAALRAELE-- 170

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1239 etrevvdlskykATKSDLETQISSLNEKLANLNrkyeevceevlhakkkeiSAKDEKELLHFSIEQEIKDQKERCDKSLT 1318
Cdd:COG4942    171 ------------AERAELEALLAELEEERAALE------------------ALKAERQKLLARLEKELAELAAELAELQQ 220

                          250       260
                   ....*....|....*....|..
gi 1034591230 1319 TITELQRRIQESAKQIEAKDNK 1340
Cdd:COG4942    221 EAEELEALIARLEAEAAAAAER 242
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
509-686 2.77e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 45.68  E-value: 2.77e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  509 DEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIK 588
Cdd:COG4913    616 EAELAELEEELAEAEERLEALEAELDALQERREALQRLAEYSWDEIDVASAEREIAELEAELERLDASSDDLAALEEQLE 695

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  589 QNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAK-----ELSAKLALSIPAEKFENMKSSLSNEV 663
Cdd:COG4913    696 ELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARlelraLLEERFAAALGDAVERELRENLEERI 775

                          170       180
                   ....*....|....*....|...
gi 1034591230  664 NEKAKKLVEMEREHEKSLSEIRQ 686
Cdd:COG4913    776 DALRARLNRAEEELERAMRAFNR 798
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 156-280 2.92e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 44.95  E-value: 2.92e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  156 TALHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLIDRGAD----------------------- 212
Cdd:PHA02874    37 TPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVDtsilpipciekdmiktildcgid 116

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  213 VNSRDKQNRTALMLGCEYGCRDAVEVLIKNGADISLLDALGHDSSYYARIGDNLDILTLL--KTASENTN 280
Cdd:PHA02874   117 VNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLleKGAYANVK 186
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1201-1432 3.11e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 45.31  E-value: 3.11e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1201 GIIKasLREKEEESQNKMEEVS-------------------------------KLQSEVQNTKQALKKLETREV-VDLSK 1248
Cdd:COG1196    166 GISK--YKERKEEAERKLEATEenlerledilgelerqleplerqaekaeryrELKEELKELEAELLLLKLRELeAELEE 243

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1249 YKATKSDLETQISSLNEKLANLNRKYEEVcEEVLHAKKKEISAKDEKELLHFS----IEQEIKDQKERCDKSLTTITELQ 1324
Cdd:COG1196    244 LEAELEELEAELEELEAELAELEAELEEL-RLELEELELELEEAQAEEYELLAelarLEQDIARLEERRRELEERLEELE 322

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1325 RRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQhQEVIAIY 1404
Cdd:COG1196    323 EELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRA-AAELAAQ 401

                          250       260
                   ....*....|....*....|....*...
gi 1034591230 1405 RTHLLSAAQGHMDEdvQEALLQIIQMRQ 1432
Cdd:COG1196    402 LEELEEAEEALLER--LERLEEELEELE 427
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 58-205 3.33e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 45.00  E-value: 3.33e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230   58 LMKAAERGDVEKVTSILAKKGVNPGKLDVEGRSVFHVVTSKGNLEcLNAILIHGV------DITTSDTAGRNALHLAAKY 131
Cdd:cd22192     21 LLLAAKENDVQAIKKLLKCPSCDLFQRGALGETALHVAALYDNLE-AAVVLMEAApelvnePMTSDLYQGETALHIAVVN 99

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  132 GHALCLQKLLQYNcptehADLQ-----------GRTAL-----HDAAMADCPSS---IQLLCDHGASVNAKDVDGRTPL- 191
Cdd:cd22192    100 QNLNLVRELIARG-----ADVVspratgtffrpGPKNLiyygeHPLSFAACVGNeeiVRLLIEHGADIRAQDSLGNTVLh 174

                          170
                   ....*....|....
gi 1034591230  192 VLATQMSRPTICQL 205
Cdd:cd22192    175 ILVLQPNKTFACQM 188
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1019-1234 3.76e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 44.44  E-value: 3.76e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1019 KATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRdktvliekshEMERALSRKTDELNKQLKDLSQK 1098
Cdd:COG3883     29 QAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIA----------EAEAEIEERREELGERARALYRS 98

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1099 YTEVkNVKEKLVeeNAKQTSEIL----AVQNLLQKQHVPLEQVEALKKSLngtiENLKEELKSMQRCYEKEQQTVTKLHQ 1174
Cdd:COG3883     99 GGSV-SYLDVLL--GSESFSDFLdrlsALSKIADADADLLEELKADKAEL----EAKKAELEAKLAELEALKAELEAAKA 171

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1175 LLENQKnssvplAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQA 1234
Cdd:COG3883    172 ELEAQQ------AEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAA 225
Ank_5 pfam13857
Ankyrin repeats (many copies);
140-194 3.79e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 39.64  E-value: 3.79e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1034591230  140 LLQY-NCPTEHADLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLA 194
Cdd:pfam13857    1 LLEHgPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PRK11281 PRK11281
mechanosensitive channel MscK;
781-1144 4.48e-04

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 44.90  E-value: 4.48e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  781 IDDLN-RKLLDVTQKYTEKKLEMEKLLLENdslskdvsrletvfvppekhekeIIALKSNIVELKKQLSELKKKCGEDQE 859
Cdd:PRK11281    45 LDALNkQKLLEAEDKLVQQDLEQTLALLDK-----------------------IDRQKEETEQLKQQLAQAPAKLRQAQA 101

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  860 KIHALTSENTN-LKKMMSNQYVPvktheevkmTLNDTLAKTNRELLDVKKKFEDINQEFVKikdkneiLKRNLENTQNQI 938
Cdd:PRK11281   102 ELEALKDDNDEeTRETLSTLSLR---------QLESRLAQTLDQLQNAQNDLAEYNSQLVS-------LQTQPERAQAAL 165

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  939 KAEYISLAEHEAKMSSLSQSMRKVQDSNAEILanyrkgQEEIVTLHAEIKAQKKEL---DTIQECIKVKYapivsfEECE 1015
Cdd:PRK11281   166 YANSQRLQQIRNLLKGGKVGGKALRPSQRVLL------QAEQALLNAQNDLQRKSLegnTQLQDLLQKQR------DYLT 233

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1016 RKFKATEKELKD----------QLSEQTQKYSVSEEEVKKnKQENDKLKKEiftlqkdlrdktvlIEKSHEMERALSRKT 1085
Cdd:PRK11281   234 ARIQRLEHQLQLlqeainskrlTLSEKTVQEAQSQDEAAR-IQANPLVAQE--------------LEINLQLSQRLLKAT 298

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1034591230 1086 DELNkqlkDLSQKYTEVKNVKEklveenakqtseilavqNLLQKQHVPLEQVEALKKSL 1144
Cdd:PRK11281   299 EKLN----TLTQQNLRVKNWLD-----------------RLTQSERNIKEQISVLKGSL 336
PHA02798 PHA02798
ankyrin-like protein; Provisional
 170-247 4.66e-04

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 44.44  E-value: 4.66e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  170 IQLLCDHGASVNAKDVDGRTPLVlaTQMSRPTICQL-----LIDRGADVNSRDKQNRTALMLGCEYGCR---DAVEVLIK 241
Cdd:PHA02798    92 VKILIENGADINKKNSDGETPLY--CLLSNGYINNLeillfMIENGADTTLLDKDGFTMLQVYLQSNHHidiEIIKLLLE 169


                   ....*.
gi 1034591230  242 NGADIS 247
Cdd:PHA02798   170 KGVDIN 175
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 476-1131 4.80e-04

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 44.96  E-value: 4.80e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  476 AKQDRLKLQNELAHKVAECKAL------------ALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLAL 543
Cdd:TIGR00618  251 AQEEQLKKQQLLKQLRARIEELraqeavleetqeRINRARKAAPLAAHIKAVTQIEQQAQRIHTELQSKMRSRAKLLMKR 330

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  544 KEHLTSEAASGNHRLTEEL-----------KDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQ 612
Cdd:TIGR00618  331 AAHVKQQSSIEEQRRLLQTlhsqeihirdaHEVATSIREISCQQHTLTQHIHTLQQQKTTLTQKLQSLCKELDILQREQA 410

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  613 KELSMCEMEREKKGRKV---TEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKR 689
Cdd:TIGR00618  411 TIDTRTSAFRDLQGQLAhakKQQELQQRYAELCAAAITCTAQCEKLEKIHLQESAQSLKEREQQLQTKEQIHLQETRKKA 490

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  690 ELENVKAKLAQHVKP----EEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYV 765
Cdd:TIGR00618  491 VVLARLLELQEEPCPlcgsCIHPNPARQDIDNPGPLTRRMQRGEQTYAQLETSEEDVYHQLTSERKQRASLKEQMQEIQQ 570

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  766 PLKVSEDMKKSHDAIIDDLnRKLLDVTQKYTEKKLEMEKLLLEndslskdVSRLETVFVPPEKHEKEIIALKSNIVE--- 842
Cdd:TIGR00618  571 SFSILTQCDNRSKEDIPNL-QNITVRLQDLTEKLSEAEDMLAC-------EQHALLRKLQPEQDLQDVRLHLQQCSQela 642

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  843 -LKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLND--TLAKTNRELLDVKKKFEDINQEFVK 919
Cdd:TIGR00618  643 lKLTALHALQLTLTQERVREHALSIRVLPKELLASRQLALQKMQSEKEQLTYWkeMLAQCQTLLRELETHIEEYDREFNE 722

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  920 IKDKNEILKRNLeNTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEivTLHAEIKAQKKELDTIQE 999
Cdd:TIGR00618  723 IENASSSLGSDL-AAREDALNQSLKELMHQARTVLKARTEAHFNNNEEVTAALQTGAELS--HLAAEIQFFNRLREEDTH 799

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1000 CIKVKYAPIvsfeECERKFKATEKELKDQLSEQtqkysvSEEEVKKNKQENDKLKKEIFTLQKDLRDKtvliekshemer 1079
Cdd:TIGR00618  800 LLKTLEAEI----GQEIPSDEDILNLQCETLVQ------EEEQFLSRLEEKSATLGEITHQLLKYEEC------------ 857

                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1034591230 1080 alSRKTDELNKQLKDLSQ--KYTEVKNVKEKLVEENA--KQTSEILAVQN-LLQKQH 1131
Cdd:TIGR00618  858 --SKQLAQLTQEQAKIIQlsDKLNGINQIKIQFDGDAliKFLHEITLYANvRLANQS 912
46 PHA02562
endonuclease subunit; Provisional
 628-853 4.97e-04

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 44.62  E-value: 4.97e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  628 KVTEMEGQAKELSAKLALSIPA----EKFENMKSSLSNEVNEKAKKLVEMEREhekslsEIRQLKRELENVKAKLAQHVK 703
Cdd:PHA02562   175 KIRELNQQIQTLDMKIDHIQQQiktyNKNIEEQRKKNGENIARKQNKYDELVE------EAKTIKAEIEELTDELLNLVM 248

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  704 PEEheqvksRLEQKSGELGKKITELTLKNQTLQKEIeKVYLDNKL-----------------LKEQAHNLTI---EMKNH 763
Cdd:PHA02562   249 DIE------DPSAALNKLNTAAAKIKSKIEQFQKVI-KMYEKGGVcptctqqisegpdritkIKDKLKELQHsleKLDTA 321

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  764 YVPLKVSEDMkkshdaiIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVppeKHEKEIIALKSNIVEL 843
Cdd:PHA02562   322 IDELEEIMDE-------FNEQSKKLLELKNKISTNKQSLITLVDKAKKVKAAIEELQAEFV---DNAEELAKLQDELDKI 391

                          250
                   ....*....|
gi 1034591230  844 KKQLSELKKK 853
Cdd:PHA02562   392 VKTKSELVKE 401
PTZ00121 PTZ00121
MAEBL; Provisional
 948-1337 5.05e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 44.75  E-value: 5.05e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  948 HEAKMSSLSQ--SMRKVQDSNAEILANYRKGQEEIVTLHAEIK----AQKKELDTIQECIKVKYApiVSFEECERKFKAT 1021
Cdd:PTZ00121  1056 HEGKAEAKAHvgQDEGLKPSYKDFDFDAKEDNRADEATEEAFGkaeeAKKTETGKAEEARKAEEA--KKKAEDARKAEEA 1133

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1022 EKELKDQLSEQTQKySVSEEEVKKNKQENDKLKKEIFTLQKDLRdKTVLIEKSHEMERALS-RKTDELNKqlKDLSQKYT 1100
Cdd:PTZ00121  1134 RKAEDARKAEEARK-AEDAKRVEIARKAEDARKAEEARKAEDAK-KAEAARKAEEVRKAEElRKAEDARK--AEAARKAE 1209

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1101 EVKNVKEKLVEENAKQTSEILAVQNLLQKQHVP--LEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLEN 1178
Cdd:PTZ00121  1210 EERKAEEARKAEDAKKAEAVKKAEEAKKDAEEAkkAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEK 1289

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1179 QKNSSVPLAEHLQIKEAFEKEVGIIKAS--LREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDL 1256
Cdd:PTZ00121  1290 KKADEAKKAEEKKKADEAKKKAEEAKKAdeAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAA 1369

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1257 ETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEA 1336
Cdd:PTZ00121  1370 EKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEA 1449


                   .
gi 1034591230 1337 K 1337
Cdd:PTZ00121  1450 K 1450
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 547-756 5.16e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 43.98  E-value: 5.16e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  547 LTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKG 626
Cdd:COG4942     10 LLALAAAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELE 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  627 RKVTEMEGQAKELSAKLALSIPA-EKFEN-------MKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKL 698
Cdd:COG4942     90 KEIAELRAELEAQKEELAELLRAlYRLGRqpplallLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAEL 169

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1034591230  699 AQhvKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNL 756
Cdd:COG4942    170 EA--ERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEEL 225
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 153-184 5.73e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 38.81  E-value: 5.73e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1034591230  153 QGRTALHDAA-MADCPSSIQLLCDHGASVNAKD 184
Cdd:pfam00023    1 DGNTPLHLAAgRRGNLEIVKLLLSKGADVNARD 33
CagA_N pfam18971
CagA protein; The Helicobacter pylori type IV secretion effector CagA is a major bacterial ...
 1048-1333 6.09e-04

CagA protein; The Helicobacter pylori type IV secretion effector CagA is a major bacterial virulence determinant and critical for gastric carcinogenesis. X-ray crystallographic analysis of the N-terminal CagA fragment (residues 1-876) revealed that the region has a structure comprised of three discrete domains. Domain I constitutes a mobile CagA N terminus, while Domain II tethers CagA to the plasma membrane by interacting with membrane phosphatidylserine. Domain III interacts intramolecularly with the intrinsically disordered C-terminal region, and this interaction potentiates the pathogenic scaffold/hub function of CagA.


Pssm-ID: 408741 [Multi-domain]  Cd Length: 876  Bit Score: 44.38  E-value: 6.09e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1048 QENDKLKKEIFTLQKDLRDKTVLIEKS-----------------HEMERALsRKTDELNKQLKDLSQKYTEVKNVKEKLV 1110
Cdd:pfam18971  573 QEANKLIKDFLSSNKELAGKALNFNKAvaeakstgnydevkkaqKDLEKSL-RKREHLEKEVEKKLESKSGNKNKMEAKA 651

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1111 EENAkQTSEILAVQNLLQKQHVP----LEQVEALKKSLNGTIENLKEELKSMQRCYEKeqqtvtklhqlLENQKNSSVPL 1186
Cdd:pfam18971  652 QANS-QKDEIFALINKEANRDARaiayTQNLKGIKRELSDKLEKISKDLKDFSKSFDE-----------FKNGKNKDFSK 719

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1187 AEH-LQIKEAFEKEVGIikaslrekeeesqnKMEEVSKlqseVQNTKQALKKLETREVVDLSKYKATKSDLETQISS--L 1263
Cdd:pfam18971  720 AEEtLKALKGSVKDLGI--------------NPEWISK----VENLNAALNEFKNGKNKDFSKVTQAKSDLENSVKDviI 781

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034591230 1264 NEKLANlnrKYEEVCEEVLHAKKKEISAKDEK---ELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQ 1333
Cdd:pfam18971  782 NQKVTD---KVDNLNQAVSVAKAMGDFSRVEQvlaDLKNFSKEQLAQQAQKNEDFNTGKNSELYQSVKNSVNK 851
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
 1015-1181 6.13e-04

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 44.15  E-value: 6.13e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1015 ERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKT--------- 1085
Cdd:PRK05771    74 EEKKKVSVKSLEELIKDVEEELEKIEKEIKELEEEISELENEIKELEQEIERLEPWGNFDLDLSLLLGFKYvsvfvgtvp 153

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1086 -DELNKQLKDLSQKYTE-VKNVKEKLV------EENAKQTSEILAvQNLLQKQHVP--------LEQVEALKKSLNGTIE 1149
Cdd:PRK05771   154 eDKLEELKLESDVENVEyISTDKGYVYvvvvvlKELSDEVEEELK-KLGFERLELEeegtpselIREIKEELEEIEKERE 232

                          170       180       190
                   ....*....|....*....|....*....|..
gi 1034591230 1150 NLKEELKSMQRCYEKEQQTVtklHQLLENQKN 1181
Cdd:PRK05771   233 SLLEELKELAKKYLEELLAL---YEYLEIELE 261
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
 597-861 6.18e-04

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 44.15  E-value: 6.18e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  597 FKRDEGKLIEEnkrLQKE-----LSMCEMEREKKGRKVTEMEGQAKELSAKL------ALSIPAEKFENMKSSLSNEVNE 665
Cdd:PRK05771    14 LKSYKDEVLEA---LHELgvvhiEDLKEELSNERLRKLRSLLTKLSEALDKLrsylpkLNPLREEKKKVSVKSLEELIKD 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  666 KAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQhVKP-------EEHEQVKSRLEQKSGELGKKITELTLKNQTLQKE 738
Cdd:PRK05771    91 VEEELEKIEKEIKELEEEISELENEIKELEQEIER-LEPwgnfdldLSLLLGFKYVSVFVGTVPEDKLEELKLESDVENV 169

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  739 IEKVYLDNKL------LKEQAHNLTIEMKNH-YVPLKVSE------------DMKKSHDAIIDDLNRKLLDVTQKYTEKK 799
Cdd:PRK05771   170 EYISTDKGYVyvvvvvLKELSDEVEEELKKLgFERLELEEegtpselireikEELEEIEKERESLLEELKELAKKYLEEL 249

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034591230  800 LEMEKLLL----ENDSLSKDVSRLETVFVP---PEKHEKEIIALKSNIVELKKQLSELKKKcgEDQEKI 861
Cdd:PRK05771   250 LALYEYLEieleRAEALSKFLKTDKTFAIEgwvPEDRVKKLKELIDKATGGSAYVEFVEPD--EEEEEV 316
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1212-1356 6.97e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 42.99  E-value: 6.97e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1212 EESQNKMEEVSKLQSEVQNTKQALKKLEtREVVDLSK----YKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKK 1287
Cdd:COG1579      3 PEDLRALLDLQELDSELDRLEHRLKELP-AELAELEDelaaLEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQ 81

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034591230 1288 EISAKDEKELLhfSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALN 1356
Cdd:COG1579     82 LGNVRNNKEYE--ALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELD 148
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1204-1399 7.78e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 43.67  E-value: 7.78e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1204 KASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLEtrevVDLSKYKATKSDLETQISSLNEKLAnlnRKYEEVCEEVLH 1283
Cdd:COG3883     22 QKELSELQAELEAAQAELDALQAELEELNEEYNELQ----AELEALQAEIDKLQAEIAEAEAEIE---ERREELGERARA 94

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1284 AKKKE---------ISAKDEKELLH--FSIEQEIKDQKERcdksLTTITELQRRIQESAKQIEAKDNKITELLNDVERLK 1352
Cdd:COG3883     95 LYRSGgsvsyldvlLGSESFSDFLDrlSALSKIADADADL----LEELKADKAELEAKKAELEAKLAELEALKAELEAAK 170

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*..
gi 1034591230 1353 QALNGLsqltytsgnpTKRQSQLIDTLQHQVKSLEQQLADADRQHQE 1399
Cdd:COG3883    171 AELEAQ----------QAEQEALLAQLSAEEAAAEAQLAELEAELAA 207
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
 1148-1359 8.84e-04

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 43.76  E-value: 8.84e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1148 IENLKEELKSMQ-RCYEKEQQTVTKLHQLLENQKNssvplAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQS 1226
Cdd:PRK05771    33 IEDLKEELSNERlRKLRSLLTKLSEALDKLRSYLP-----KLNPLREEKKKVSVKSLEELIKDVEEELEKIEKEIKELEE 107

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1227 EVQNTKQALKKLEtREVVDLSKYKATKSDLETQISSLN----------EKLANLNRKYEEVCEEVLHAKK---------- 1286
Cdd:PRK05771   108 EISELENEIKELE-QEIERLEPWGNFDLDLSLLLGFKYvsvfvgtvpeDKLEELKLESDVENVEYISTDKgyvyvvvvvl 186

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1287 KEISAKDEKELLHFS-IEQEIKDQK---ERCDKSLTTITELQRRIQESAKQIEAKDNKITE--------LLNDVERLKQA 1354
Cdd:PRK05771   187 KELSDEVEEELKKLGfERLELEEEGtpsELIREIKEELEEIEKERESLLEELKELAKKYLEellalyeyLEIELERAEAL 266


                   ....*
gi 1034591230 1355 LNGLS 1359
Cdd:PRK05771   267 SKFLK 271
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1245-1402 8.94e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 43.28  E-value: 8.94e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1245 DLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLhakkkeisakdekellhfSIEQEIKDQKERcdkslttITELQ 1324
Cdd:COG3883     17 QIQAKQKELSELQAELEAAQAELDALQAELEELNEEYN------------------ELQAELEALQAE-------IDKLQ 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1325 RRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTyTSGNP-------------TKRQSQLIDTLQHQVKSLEQQLA 1391
Cdd:COG3883     72 AEIAEAEAEIEERREELGERARALYRSGGSVSYLDVLL-GSESFsdfldrlsalskiADADADLLEELKADKAELEAKKA 150

                          170
                   ....*....|.
gi 1034591230 1392 DADRQHQEVIA 1402
Cdd:COG3883    151 ELEAKLAELEA 161
PRK12704 PRK12704
phosphodiesterase; Provisional
 1140-1312 1.03e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 43.61  E-value: 1.03e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1140 LKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLhQLLENQKnssvplaEHLQIKEAFEKEVGIIKASLREKEEESQNKME 1219
Cdd:PRK12704    25 RKKIAEAKIKEAEEEAKRILEEAKKEAEAIKKE-ALLEAKE-------EIHKLRNEFEKELRERRNELQKLEKRLLQKEE 96

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1220 EVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKL---ANLNRkyEEVCEEVLHAKKKEisAKDEKE 1296
Cdd:PRK12704    97 NLDRKLELLEKREEELEKKEKELEQKQQELEKKEEELEELIEEQLQELeriSGLTA--EEAKEILLEKVEEE--ARHEAA 172

                          170
                   ....*....|....*.
gi 1034591230 1297 LLHFSIEQEIKDQKER 1312
Cdd:PRK12704   173 VLIKEIEEEAKEEADK 188
Ank_5 pfam13857
Ankyrin repeats (many copies);
175-224 1.05e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 38.48  E-value: 1.05e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1034591230  175 DHG-ASVNAKDVDGRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTAL 224
Cdd:pfam13857    3 EHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
PHA02946 PHA02946
ankyin-like protein; Provisional
 170-247 1.09e-03

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 43.12  E-value: 1.09e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  170 IQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTAL--MLGCEYGCRDAVEVLIKNGADIS 247
Cdd:PHA02946    55 VEELLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLyyLSGTDDEVIERINLLVQYGAKIN 134
PLN02939 PLN02939
transferase, transferring glycosyl groups
 271-623 1.11e-03

transferase, transferring glycosyl groups


Pssm-ID: 215507 [Multi-domain]  Cd Length: 977  Bit Score: 43.74  E-value: 1.11e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  271 LLKTASENTNKGRELWKKGPSLQQRNlTHMQDEVNVKSHQR-EHQNIQDLEI-ENEDLKERLRKIQQEQRI-LLDKVNGL 347
Cdd:PLN02939    65 LQSNTDENGQLENTSLRTVMELPQKS-TSSDDDHNRASMQRdEAIAAIDNEQqTNSKDGEQLSDFQLEDLVgMIQNAEKN 143

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  348 QLQLNEEVMVA-DDLE---SEREKL----------------KSLLAAKEKQHEESLRtiEALKNRFKYFESDHLGSGSHF 407
Cdd:PLN02939   144 ILLLNQARLQAlEDLEkilTEKEALqgkinilemrlsetdaRIKLAAQEKIHVEILE--EQLEKLRNELLIRGATEGLCV 221

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  408 SN--------RKEDMLLKQGQMYM----ADSQCTSPGIPAHMQSRSMLRPLELSLPSQTSYSENEILKkeLEAMRTFCES 475
Cdd:PLN02939   222 HSlskeldvlKEENMLLKDDIQFLkaelIEVAETEERVFKLEKERSLLDASLRELESKFIVAQEDVSK--LSPLQYDCWW 299

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  476 AKQDRLKLQNELAHKVAECKALALECERvkeDSDEQIKQLEDALKdvqkrmyesEGKVKQMQTHFLALkehltseaasgn 555
Cdd:PLN02939   300 EKVENLQDLLDRATNQVEKAALVLDQNQ---DLRDKVDKLEASLK---------EANVSKFSSYKVEL------------ 355

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034591230  556 hrlteeLKDQLKDLKVKYEGASAEVgklRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMERE 623
Cdd:PLN02939   356 ------LQQKLKLLEERLQASDHEI---HSYIQLYQESIKEFQDTLSKLKEESKKRSLEHPADDMPSE 414
Ank_5 pfam13857
Ankyrin repeats (many copies);
112-159 1.13e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 38.48  E-value: 1.13e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1034591230  112 VDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALH 159
Cdd:pfam13857    7 IDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALD 54
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1018-1312 1.25e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 43.37  E-value: 1.25e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1018 FKATEK--ELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKdlrdktvlIEKSHEME---RALSRKTDELNKQL 1092
Cdd:COG4913    606 FDNRAKlaALEAELAELEEELAEAEERLEALEAELDALQERREALQR--------LAEYSWDEidvASAEREIAELEAEL 677

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1093 KDLSQKYTEVKNVKEKLVEenakqtseilavqnlLQKQhvpLEQVEALKKSLNGTIENLKEELKSMQRcyekEQQTVTkl 1172
Cdd:COG4913    678 ERLDASSDDLAALEEQLEE---------------LEAE---LEELEEELDELKGEIGRLEKELEQAEE----ELDELQ-- 733

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1173 HQLLENQKNSSVPLAEHLQikEAFEkevgiikaslREKEEESQNKMEEvsKLQSEVQNTKQALKKLETReVVDL-----S 1247
Cdd:COG4913    734 DRLEAAEDLARLELRALLE--ERFA----------AALGDAVERELRE--NLEERIDALRARLNRAEEE-LERAmrafnR 798

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034591230 1248 KYKATKSDLETQISSLNEKLAnlnrKYEEVCEEVLHAKKKEI------SAKDEKELLHFSIEQEIKDQKER 1312
Cdd:COG4913    799 EWPAETADLDADLESLPEYLA----LLDRLEEDGLPEYEERFkellneNSIEFVADLLSKLRRAIREIKER 865
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
506-739 1.45e-03

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 43.11  E-value: 1.45e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  506 EDSDEQIKQLEDALKDVQKRMYESEGKVKQMqthflalkehltsEAASgnhrlteELKDQLKDLKVKYEGASAEVGKLRN 585
Cdd:PRK02224   471 EEDRERVEELEAELEDLEEEVEEVEERLERA-------------EDLV-------EAEDRIERLEERREDLEELIAERRE 530

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  586 QIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLalsipaEKFENMKSSLS----- 660
Cdd:PRK02224   531 TIEEKRERAEELRERAAELEAEAEEKREAAAEAEEEAEEAREEVAELNSKLAELKERI------ESLERIRTLLAaiada 604

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  661 ----NEVNEKAKKLVEMEREHEKSLSEIRQLKRELEnvkAKLaQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQ 736
Cdd:PRK02224   605 edeiERLREKREALAELNDERRERLAEKRERKRELE---AEF-DEARIEEAREDKERAEEYLEQVEEKLDELREERDDLQ 680


                   ...
gi 1034591230  737 KEI 739
Cdd:PRK02224   681 AEI 683
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
 797-1353 1.80e-03

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 42.89  E-value: 1.80e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  797 EKKLEMEKLLLE---NDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKK----CGEDQEKIHALTSENT 869
Cdd:pfam10174  203 QKEKENIHLREElhrRNQLQPDPAKTKALQTVIEMKDTKISSLERNIRDLEDEVQMLKTNgllhTEDREEEIKQMEVYKS 282

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  870 NLKKMMSNQyvpvkthEEVKMTLNdtlaKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNL---ENTQNQIKAEYISL- 945
Cdd:pfam10174  283 HSKFMKNKI-------DQLKQELS----KKESELLALQTKLETLTNQNSDCKQHIEVLKESLtakEQRAAILQTEVDALr 351

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  946 AEHEAKMSSLSQSMRKVQDSnaeilanyrkgQEEIVTLHAEIKAQKKELDtiqecikVKyapivsfeecERKFKATEKE- 1024
Cdd:pfam10174  352 LRLEEKESFLNKKTKQLQDL-----------TEEKSTLAGEIRDLKDMLD-------VK----------ERKINVLQKKi 403

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1025 --LKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEK-SHEMERALSRKTDELNKQLKDLsqkyte 1101
Cdd:pfam10174  404 enLQEQLRDKDKQLAGLKERVKSLQTDSSNTDTALTTLEEALSEKERIIERlKEQREREDRERLEELESLKKEN------ 477

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1102 vKNVKEKLVeenakqtseilAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLhqllENQKN 1181
Cdd:pfam10174  478 -KDLKEKVS-----------ALQPELTEKESSLIDLKEHASSLASSGLKKDSKLKSLEIAVEQKKEECSKL----ENQLK 541

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1182 SSVPLAEHLQIKEAFEKEVgiikaslREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQIS 1261
Cdd:pfam10174  542 KAHNAEEAVRTNPEINDRI-------RLLEQEVARYKEESGKAQAEVERLLGILREVENEKNDKDKKIAELESLTLRQMK 614

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1262 SLNEKLANLNRKYEEvcEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKI 1341
Cdd:pfam10174  615 EQNKKVANIKHGQQE--MKKKGAQLLEEARRREDNLADNSQQLQLEELMGALEKTRQELDATKARLSSTQQSLAEKDGHL 692

                          570
                   ....*....|..
gi 1034591230 1342 TELlnDVERLKQ 1353
Cdd:pfam10174  693 TNL--RAERRKQ 702
Ank_4 pfam13637
Ankyrin repeats (many copies);
54-104 1.90e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 37.64  E-value: 1.90e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1034591230   54 YDDRLMKAAERGDVEkVTSILAKKGVNPGKLDVEGRSVFHVVTSKGNLECL 104
Cdd:pfam13637    1 ELTALHAAAASGHLE-LLRLLLEKGADINAVDGNGETALHFAASNGNVEVL 50
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 560-705 2.10e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 41.45  E-value: 2.10e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  560 EELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEF----KRDEGKLieENKRLQKELSMCEMEREKKGRKVTEMEGQ 635
Cdd:COG1579     34 AELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVeariKKYEEQL--GNVRNNKEYEALQKEIESLKRRISDLEDE 111

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  636 AKELSAKLalsipaEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPE 705
Cdd:COG1579    112 ILELMERI------EELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELEAEREELAAKIPPE 175
PRK12704 PRK12704
phosphodiesterase; Provisional
 1015-1165 2.46e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 42.07  E-value: 2.46e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1015 ERKFKATEKELKDQLSE-QTQKYSVSEEEVKKNKQENDKLK-----------KEIFTLQKDLRDKTVLIEKSHEmerALS 1082
Cdd:PRK12704    30 EAKIKEAEEEAKRILEEaKKEAEAIKKEALLEAKEEIHKLRnefekelrerrNELQKLEKRLLQKEENLDRKLE---LLE 106

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1083 RKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKqhvpleqvEALKKSLNGTIENLKEELKSMQRCY 1162
Cdd:PRK12704   107 KREEELEKKEKELEQKQQELEKKEEELEELIEEQLQELERISGLTAE--------EAKEILLEKVEEEARHEAAVLIKEI 178


                   ...
gi 1034591230 1163 EKE 1165
Cdd:PRK12704   179 EEE 181
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
 1070-1212 2.52e-03

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 42.51  E-value: 2.52e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1070 LIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKqtseilavqnLLQKQHVPLEQ-VEALKKSLNGTI 1148
Cdd:PRK00409   521 LIASLEELERELEQKAEEAEALLKEAEKLKEELEEKKEKLQEEEDK----------LLEEAEKEAQQaIKEAKKEADEII 590

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034591230 1149 ENLkeelksmqRCYEKEQQTVTKLHQLLENQKNssvpLAEHLQIKEAFEKEVGIIKASLREKEE 1212
Cdd:PRK00409   591 KEL--------RQLQKGGYASVKAHELIEARKR----LNKANEKKEKKKKKQKEKQEELKVGDE 642
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 220-247 2.54e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 36.85  E-value: 2.54e-03
                           10        20
                   ....*....|....*....|....*...
gi 1034591230  220 NRTALMLGCEYGCRDAVEVLIKNGADIS 247
Cdd:pfam13606    2 GNTPLHLAARNGRLEIVKLLLENGADIN 29
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 578-1236 2.57e-03

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 42.47  E-value: 2.57e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  578 AEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELsmcemerekkgRKVTEMEGQAKELSAKLAlsipaekfenmks 657
Cdd:pfam01576   12 EELQKVKERQQKAESELKELEKKHQQLCEEKNALQEQL-----------QAETELCAEAEEMRARLA------------- 67

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  658 slsnevnEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKP-----EEHEQVKSRLEQKSGELGKKITELTLKN 732
Cdd:pfam01576   68 -------ARKQELEEILHELESRLEEEEERSQQLQNEKKKMQQHIQDleeqlDEEEAARQKLQLEKVTTEAKIKKLEEDI 140

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  733 QTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLldvtQKYTEKKLEMEKLllendsl 812
Cdd:pfam01576  141 LLLEDQNSKLSKERKLLEERISEFTSNLAEEEEKAKSLSKLKNKHEAMISDLEERL----KKEEKGRQELEKA------- 209

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  813 skdvsrletvfvpPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALtsentnlkkmmsnqyvpvKTHEEVKMTL 892
Cdd:pfam01576  210 -------------KRKLEGESTDLQEQIAELQAQIAELRAQLAKKEEELQAA------------------LARLEEETAQ 258

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  893 NDTLAKTNRELL-DVKKKFEDINQEFVKiKDKNEILKRNLENTQNQIKAEyislaeheakmsslsqsMRKVQDSNAEILA 971
Cdd:pfam01576  259 KNNALKKIRELEaQISELQEDLESERAA-RNKAEKQRRDLGEELEALKTE-----------------LEDTLDTTAAQQE 320

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  972 NYRKGQEEIVTLHAEIKAQKKELDTiqecikvkyapivSFEECERKFKATEKELKDQLsEQTQKYSVSEEevkKNKQend 1051
Cdd:pfam01576  321 LRSKREQEVTELKKALEEETRSHEA-------------QLQEMRQKHTQALEELTEQL-EQAKRNKANLE---KAKQ--- 380

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1052 KLKKEIFTLQKDLRdktVLIEKSHEMERalsrKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQ--- 1128
Cdd:pfam01576  381 ALESENAELQAELR---TLQQAKQDSEH----KRKKLEGQLQELQARLSESERQRAELAEKLSKLQSELESVSSLLNeae 453

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1129 -KQHVPLEQVEALKKSLNGTIENLKEELKsmqrcyeKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASL 1207
Cdd:pfam01576  454 gKNIKLSKDVSSLESQLQDTQELLQEETR-------QKLNLSTRLRQLEDERNSLQEQLEEEEEAKRNVERQLSTLQAQL 526

                          650       660       670
                   ....*....|....*....|....*....|....*.
gi 1034591230 1208 R------EKEEESQNKMEEVSK-LQSEVQNTKQALK 1236
Cdd:pfam01576  527 SdmkkklEEDAGTLEALEEGKKrLQRELEALTQQLE 562
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 457-754 2.65e-03

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 42.31  E-value: 2.65e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  457 SENEILKKELEAMRTFCESAKQDRLklqnELAHKVAECKALALECERVKEDSDEQIKQ--LEDALKDVQKRMYESEGKVK 534
Cdd:NF033838   111 SEAELTSKTKKELDAAFEQFKKDTL----EPGKKVAEATKKVEEAEKKAKDQKEEDRRnyPTNTYKTLELEIAESDVEVK 186

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  535 QMQTHFLALKEHLTSEaasgnhrlteelKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGklIEENKRLQKE 614
Cdd:NF033838   187 KAELELVKEEAKEPRD------------EEKIKQAKAKVESKKAEATRLEKIKTDREKAEEEAKRRAD--AKLKEAVEKN 252

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  615 LSMCEMEREKKGRKVTEMEGQA----KELSAKLALSIPAEkfENMKS-SLSNE--VNEKAKKLVEMER------------ 675
Cdd:NF033838   253 VATSEQDKPKRRAKRGVLGEPAtpdkKENDAKSSDSSVGE--ETLPSpSLKPEkkVAEAEKKVEEAKKkakdqkeedrrn 330

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  676 ---------EHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKkiteltlknqtlqkeIEKVYLDN 746
Cdd:NF033838   331 yptntyktlELEIAESDVKVKEAELELVKEEAKEPRNEEKIKQAKAKVESKKAEATR---------------LEKIKTDR 395


                   ....*...
gi 1034591230  747 KLLKEQAH 754
Cdd:NF033838   396 KKAEEEAK 403
mukB PRK04863
chromosome partition protein MukB;
1046-1413 2.74e-03

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 42.25  E-value: 2.74e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1046 NKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYtevknvkeklveenakqtseilavqn 1125
Cdd:PRK04863   277 HANERRVHLEEALELRRELYTSRRQLAAEQYRLVEMARELAELNEAESDLEQDY-------------------------- 330

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1126 llqkqhvpleqvealkkslngtiENLKEELKSMQ---RCYEKEQQTVTKLHQLLENqknssvpLAEHLQIKEafekEVGI 1202
Cdd:PRK04863   331 -----------------------QAASDHLNLVQtalRQQEKIERYQADLEELEER-------LEEQNEVVE----EADE 376

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1203 IKASLREKEEESQnkmEEVSKLQSEVQNTKQALKKLETRE------VVDLSKYKATKSDLETQISSLNEKLANLNRKYEE 1276
Cdd:PRK04863   377 QQEENEARAEAAE---EEVDELKSQLADYQQALDVQQTRAiqyqqaVQALERAKQLCGLPDLTADNAEDWLEEFQAKEQE 453

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1277 VCEEVLHAKKKeisakdekellhFSIEQEIKDQKERCDKSLTTIT-------------ELQRRIQES---AKQIEAKDNK 1340
Cdd:PRK04863   454 ATEELLSLEQK------------LSVAQAAHSQFEQAYQLVRKIAgevsrseawdvarELLRRLREQrhlAEQLQQLRMR 521

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1341 ITEL------LNDVERLKQALNGLSQLTYTS----GNPTKRQSQLIDTLQHQVKSLEQQLADAdRQHQEVIAIYRTHLLS 1410
Cdd:PRK04863   522 LSELeqrlrqQQRAERLLAEFCKRLGKNLDDedelEQLQEELEARLESLSESVSEARERRMAL-RQQLEQLQARIQRLAA 600


                   ...
gi 1034591230 1411 AAQ 1413
Cdd:PRK04863   601 RAP 603
PRK12704 PRK12704
phosphodiesterase; Provisional
 985-1120 2.97e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 42.07  E-value: 2.97e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  985 AEIKAQKKELDTIQECIKVKyapivsfEECERKFKATEKELKDQLSEQTQKysvsEEEVKKNKQENDKLKKEIFTLQKDL 1064
Cdd:PRK12704    51 AEAIKKEALLEAKEEIHKLR-------NEFEKELRERRNELQKLEKRLLQK----EENLDRKLELLEKREEELEKKEKEL 119

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034591230 1065 RDKTVLIEKsheMERALSRKTDELNKQLKDLSQKYTE------VKNVKEKLVEENAKQTSEI 1120
Cdd:PRK12704   120 EQKQQELEK---KEEELEELIEEQLQELERISGLTAEeakeilLEKVEEEARHEAAVLIKEI 178
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 457-699 3.62e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 41.85  E-value: 3.62e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  457 SENEILKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDE---QIKQLEDALKDVQKRMYESEGKV 533
Cdd:COG1196    267 AELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEEleeELAELEEELEELEEELEELEEEL 346

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  534 KQMQTHFLALKEHLTS--EAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRL 611
Cdd:COG1196    347 EEAEEELEEAEAELAEaeEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEEL 426

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  612 QKELsmcemerekkgrkvtemegqAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKREL 691
Cdd:COG1196    427 EEAL--------------------AELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEEL 486


                   ....*...
gi 1034591230  692 ENVKAKLA 699
Cdd:COG1196    487 AEAAARLL 494
Ank_4 pfam13637
Ankyrin repeats (many copies);
187-240 3.68e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 36.87  E-value: 3.68e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1034591230  187 GRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLI 240
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 828-1388 3.80e-03

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 41.96  E-value: 3.80e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  828 KHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMmsnqyVPVKTHEEVKMTLNDTLAKTNRelLDVK 907
Cdd:TIGR01612  576 HLEKEIKDLFDKYLEIDDEIIYINKLKLELKEKIKNISDKNEYIKKA-----IDLKKIIENNNAYIDELAKISP--YQVP 648

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  908 KKFEDINQEFVKIKDK-NEILKRNLENTQNQ----IKAEYISLAEHEAKMSSLSQSMRKVQD--SNAEI------LANYR 974
Cdd:TIGR01612  649 EHLKNKDKIYSTIKSElSKIYEDDIDALYNElssiVKENAIDNTEDKAKLDDLKSKIDKEYDkiQNMETatvelhLSNIE 728

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  975 KGQEEIVTLHAEIKAQ-----KKELDTIQECIKVKYAPIVS-------FEECERKFKATEKELKDQLSEQTQKYSVSEEE 1042
Cdd:TIGR01612  729 NKKNELLDIIVEIKKHihgeiNKDLNKILEDFKNKEKELSNkindyakEKDELNKYKSKISEIKNHYNDQINIDNIKDED 808

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1043 VKKNKQENDKLKKEIfTLQKDLRDKTV------------LIEKSHEMERALSRKTDELNKQLKDLSQKY-TEVKNVKEKL 1109
Cdd:TIGR01612  809 AKQNYDKSKEYIKTI-SIKEDEIFKIInemkfmkddflnKVDKFINFENNCKEKIDSEHEQFAELTNKIkAEISDDKLND 887

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1110 VEENAKQT-SEILAVQNLLQKQHvplEQVEALKKsLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSV---- 1184
Cdd:TIGR01612  888 YEKKFNDSkSLINEINKSIEEEY---QNINTLKK-VDEYIKICENTKESIEKFHNKQNILKEILNKNIDTIKESNLieks 963

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1185 --PLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREvvdlsKYKATkSDLETQISS 1262
Cdd:TIGR01612  964 ykDKFDNTLIDKINELDKAFKDASLNDYEAKNNELIKYFNDLKANLGKNKENMLYHQFDE-----KEKAT-NDIEQKIED 1037

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1263 LNEKLANLnrkyeevcEEVLHAKKKEISAKDEKELLHfSIEQEIKDQKERCDKSLTTITELQRRIQ-----ESAKQIEAK 1337
Cdd:TIGR01612 1038 ANKNIPNI--------EIAIHTSIYNIIDEIEKEIGK-NIELLNKEILEEAEINITNFNEIKEKLKhynfdDFGKEENIK 1108

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1034591230 1338 -DNKITELLNDVERLKQALN-GLSQLTYTSgnptKRQSQLIDTLQHQVKSLEQ 1388
Cdd:TIGR01612 1109 yADEINKIKDDIKNLDQKIDhHIKALEEIK----KKSENYIDEIKAQINDLED 1157
PRK01156 PRK01156
chromosome segregation protein; Provisional
 927-1394 3.85e-03

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 41.81  E-value: 3.85e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  927 LKRNLENTQNQIKAEYISLAEHEAKMSSLsqsMRKVQDSNAEILANYRKGQEEIVTLHaEIKAQKKELDTIQECIKVKYA 1006
Cdd:PRK01156   188 LEEKLKSSNLELENIKKQIADDEKSHSIT---LKEIERLSIEYNNAMDDYNNLKSALN-ELSSLEDMKNRYESEIKTAES 263

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1007 PIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALS---- 1082
Cdd:PRK01156   264 DLSMELEKNNYYKELEERHMKIINDPVYKNRNYINDYFKYKNDIENKKQILSNIDAEINKYHAIIKKLSVLQKDYNdyik 343

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1083 --RKTDELNKQLKDLSQ---KYT----EVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKE 1153
Cdd:PRK01156   344 kkSRYDDLNNQILELEGyemDYNsylkSIESLKKKIEEYSKNIERMSAFISEILKIQEIDPDAIKKELNEINVKLQDISS 423

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1154 ELKSMQ---RCYEKEQQTVTKLHQLLENQKNSSVpLAEHLqikeAFEKEVGIIKASLREKE--EESQNKME-EVSKLQSE 1227
Cdd:PRK01156   424 KVSSLNqriRALRENLDELSRNMEMLNGQSVCPV-CGTTL----GEEKSNHIINHYNEKKSrlEEKIREIEiEVKDIDEK 498

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1228 VQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANL---NRKYEEVCEEVLHAKKKEISAKDEKELLHFS--- 1301
Cdd:PRK01156   499 IVDLKKRKEYLESEEINKSINEYNKIESARADLEDIKIKINELkdkHDKYEEIKNRYKSLKLEDLDSKRTSWLNALAvis 578

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1302 -------------IEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTytsgNP 1368
Cdd:PRK01156   579 lidietnrsrsneIKKQLNDLESRLQEIEIGFPDDKSYIDKSIREIENEANNLNNKYNEIQENKILIEKLRGKI----DN 654

                          490       500
                   ....*....|....*....|....*.
gi 1034591230 1369 TKRQSQLIDTLQHQVKSLEQQLADAD 1394
Cdd:PRK01156   655 YKKQIAEIDSIIPDLKEITSRINDIE 680
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 513-1109 4.38e-03

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 41.70  E-value: 4.38e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  513 KQLEDALKDVQKRMYESEGKV-------KQMQTHFLALKEHLTSEAASGNHRLTEE--LKDQLKDLKVKYEGASAEVGKL 583
Cdd:pfam01576   71 QELEEILHELESRLEEEEERSqqlqnekKKMQQHIQDLEEQLDEEEAARQKLQLEKvtTEAKIKKLEEDILLLEDQNSKL 150

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  584 RNQIKQNEMIVEEFKRDEGKLIEENKRLQK-----ELSMCEME----REKKGRKVTE-----MEGQAKELSAKLA----- 644
Cdd:pfam01576  151 SKERKLLEERISEFTSNLAEEEEKAKSLSKlknkhEAMISDLEerlkKEEKGRQELEkakrkLEGESTDLQEQIAelqaq 230

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  645 ----LSIPAEKFENMKSSLSNEVNEKAKK--LVEMEREHEKSLSEI------------------RQLKRELENVKAKLAQ 700
Cdd:pfam01576  231 iaelRAQLAKKEEELQAALARLEEETAQKnnALKKIRELEAQISELqedleseraarnkaekqrRDLGEELEALKTELED 310

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  701 HVKPEEHEQ-VKSRLEQKSGELGKKITELT--------------------LKNQTLQKEIEKVYLDN--KLLKEQAHNLT 757
Cdd:pfam01576  311 TLDTTAAQQeLRSKREQEVTELKKALEEETrsheaqlqemrqkhtqaleeLTEQLEQAKRNKANLEKakQALESENAELQ 390

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  758 IEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVppeKHEKEIIALK 837
Cdd:pfam01576  391 AELRTLQQAKQDSEHKRKKLEGQLQELQARLSESERQRAELAEKLSKLQSELESVSSLLNEAEGKNI---KLSKDVSSLE 467

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  838 SNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQyvpvkthEEVKMTLNDTLAKTNRELLDVKKKFEDINQEF 917
Cdd:pfam01576  468 SQLQDTQELLQEETRQKLNLSTRLRQLEDERNSLQEQLEEE-------EEAKRNVERQLSTLQAQLSDMKKKLEEDAGTL 540

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  918 VKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKV---QDSNAEILANYRKGQEEIVTLHAEIKAqkkel 994
Cdd:pfam01576  541 EALEEGKKRLQRELEALTQQLEEKAAAYDKLEKTKNRLQQELDDLlvdLDHQRQLVSNLEKKQKKFDQMLAEEKA----- 615

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  995 dtiqecIKVKYApivsfEECER-KFKATEKELKD-QLSEQTQKYSVSEEEVKKNkqeNDKLKKEIFTL--QKDLRDKTVl 1070
Cdd:pfam01576  616 ------ISARYA-----EERDRaEAEAREKETRAlSLARALEEALEAKEELERT---NKQLRAEMEDLvsSKDDVGKNV- 680

                          650       660       670       680
                   ....*....|....*....|....*....|....*....|..
gi 1034591230 1071 ieksHEME---RALSRKTDELNKQLKDLSQKYTEVKNVKEKL 1109
Cdd:pfam01576  681 ----HELErskRALEQQVEEMKTQLEELEDELQATEDAKLRL 718
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 50-285 4.62e-03

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 41.61  E-value: 4.62e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230   50 DWNKYDDRLMKAAERGDVekvtSILAKKGVNPGKLDVE-----GRSVFHVVTSKGNLECLNAILI-HGVDITTSDTAgrn 123
Cdd:TIGR00870   13 PLSDEEKAFLPAAERGDL----ASVYRDLEEPKKLNINcpdrlGRSALFVAAIENENLELTELLLnLSCRGAVGDTL--- 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  124 aLHLAAKyghalclqkllqyncptEHADLQGRTALHDAAMADCPSSIQLlcdhgasVNAKDVD----GRTPLVLATQMSR 199
Cdd:TIGR00870   86 -LHAISL-----------------EYVDAVEAILLHLLAAFRKSGPLEL-------ANDQYTSeftpGITALHLAAHRQN 140

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  200 PTICQLLIDRGADVNSR-------DKQNRTALMLGcEY--------GCRDAVEVLIKNGADISLLDALGHdssyyarigd 264
Cdd:TIGR00870  141 YEIVKLLLERGASVPARacgdffvKSQGVDSFYHG-ESplnaaaclGSPSIVALLSEDPADILTADSLGN---------- 209

                          250       260
                   ....*....|....*....|.
gi 1034591230  265 nlDILTLLKTASENTNKGREL 285
Cdd:TIGR00870  210 --TLLHLLVMENEFKAEYEEL 228
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 310-741 4.75e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 41.46  E-value: 4.75e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  310 QREHQNIQDLEIENEDLKERLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIEAL 389
Cdd:COG1196    396 AELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALL 475

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  390 KNrfkyfESDHLGSGSHFSNRKEDMLLKQGQMYMADSQctSPGIPAHMQSRSMLRPLELSLPSQTSYSENEILKKELEAM 469
Cdd:COG1196    476 EA-----ALAELLEELAEAAARLLLLLEAEADYEGFLE--GVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAAL 548

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  470 RTFCESAKQDRLKLQNEL-AHKVAECKALALECERVKEDSDEQIKQLED----ALKDVQKRMYESEGKVKQMQTHFLALK 544
Cdd:COG1196    549 QNIVVEDDEVAAAAIEYLkAAKAGRATFLPLDKIRARAALAAALARGAIgaavDLVASDLREADARYYVLGDTLLGRTLV 628

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  545 EHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREK 624
Cdd:COG1196    629 AARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERE 708

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  625 KGRKVTEMEGQAKELSAKL-ALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELE-----NVKAkl 698
Cdd:COG1196    709 LAEAEEERLEEELEEEALEeQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELERLEREIEalgpvNLLA-- 786

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|...
gi 1034591230  699 aqhvkPEEHEQVKSRLEqksgelgkkitELTLKNQTLQKEIEK 741
Cdd:COG1196    787 -----IEEYEELEERYD-----------FLSEQREDLEEARET 813
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
486-864 5.25e-03

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 41.18  E-value: 5.25e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  486 ELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLtseaasgnhrltEELKDQ 565
Cdd:PRK02224   255 TLEAEIEDLRETIAETEREREELAEEVRDLRERLEELEEERDDLLAEAGLDDADAEAVEARR------------EELEDR 322

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  566 LKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLAL 645
Cdd:PRK02224   323 DEELRDRLEECRVAAQAHNEEAESLREDADDLEERAEELREEAAELESELEEAREAVEDRREEIEELEEEIEELRERFGD 402

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  646 SipAEKFENMkSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKA-----KLAQHVKPEEHEQVKSRLEQKSGE 720
Cdd:PRK02224   403 A--PVDLGNA-EDFLEELREERDELREREAELEATLRTARERVEEAEALLEagkcpECGQPVEGSPHVETIEEDRERVEE 479

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  721 LGKKITELTLKNQTLQKEIEKVyldnkllkeqahnltiemknhyvplkvsEDMKKSHDAiIDDLNRKLLDVTQKYTEKKL 800
Cdd:PRK02224   480 LEAELEDLEEEVEEVEERLERA----------------------------EDLVEAEDR-IERLEERREDLEELIAERRE 530

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034591230  801 EMEKLLLENDSLSKDVSRLETvfvPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHAL 864
Cdd:PRK02224   531 TIEEKRERAEELRERAAELEA---EAEEKREAAAEAEEEAEEAREEVAELNSKLAELKERIESL 591
PRK11281 PRK11281
mechanosensitive channel MscK;
1021-1434 5.51e-03

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 41.44  E-value: 5.51e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1021 TEKELKDQLseqtqkysvseEEVKKNKQENDKLKkeifTLQKDLRDKTVLIEKSHEMERalsrKTDELNKQLKDLSQKYT 1100
Cdd:PRK11281    37 TEADVQAQL-----------DALNKQKLLEAEDK----LVQQDLEQTLALLDKIDRQKE----ETEQLKQQLAQAPAKLR 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1101 EVKNVKEKLVEENAKQTSEILAVQNL--LQKQhvpLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVT-------K 1171
Cdd:PRK11281    98 QAQAELEALKDDNDEETRETLSTLSLrqLESR---LAQTLDQLQNAQNDLAEYNSQLVSLQTQPERAQAALYansqrlqQ 174

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1172 LHQLLENQKNSSVPLAEHLQIKEAFEKevgiikASLREKEEESQNKMEEVSKLQsevqntkqalkkletrevvDLskYKA 1251
Cdd:PRK11281   175 IRNLLKGGKVGGKALRPSQRVLLQAEQ------ALLNAQNDLQRKSLEGNTQLQ-------------------DL--LQK 227

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1252 TKSDLETQISSLNEKLANLnrkyeevcEEVLHAKKKEISAKDEKEllhfsieQEIKDQKERCDKSLTTITELQRRIQESA 1331
Cdd:PRK11281   228 QRDYLTARIQRLEHQLQLL--------QEAINSKRLTLSEKTVQE-------AQSQDEAARIQANPLVAQELEINLQLSQ 292

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1332 KQIEAKDnKITELLNDVERLKQALNGLSQltytsgnpTKR---------------------QSQLIDTLQhQVKSLEQQL 1390
Cdd:PRK11281   293 RLLKATE-KLNTLTQQNLRVKNWLDRLTQ--------SERnikeqisvlkgslllsrilyqQQQALPSAD-LIEGLADRI 362

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1034591230 1391 ADAdRQHQ-EV---------IAIYRTHLLSAAQGHMDEDVQEALLQIIQMRQGL 1434
Cdd:PRK11281   363 ADL-RLEQfEInqqrdalfqPDAYIDKLEAGHKSEVTDEVRDALLQLLDERREL 415
PHA02798 PHA02798
ankyrin-like protein; Provisional
 70-281 5.89e-03

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 40.97  E-value: 5.89e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230   70 VTSILAKKGVNPGKLDVEGRSVFHVVTSKG---NLECLNAILIHGVDITTSDTAGRNALHLAAKYGHA-------LCLQK 139
Cdd:PHA02798    91 IVKILIENGADINKKNSDGETPLYCLLSNGyinNLEILLFMIENGADTTLLDKDGFTMLQVYLQSNHHidieiikLLLEK 170

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  140 LLQYNcptEHADLQGRTALH-------DAAMADCpssIQLLCDHGASVNAKDVDGRTPLVlatqmsrPTICQLLIDRGA- 211
Cdd:PHA02798   171 GVDIN---THNNKEKYDTLHcyfkyniDRIDADI---LKLFVDNGFIINKENKSHKKKFM-------EYLNSLLYDNKRf 237

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  212 ------------DVNSRDKQNRTALMLGCEYGCRDAVEVLIKNGADISLLDALGHdssyyarigdnldilTLLKTASENT 279
Cdd:PHA02798   238 kknildfifsyiDINQVDELGFNPLYYSVSHNNRKIFEYLLQLGGDINIITELGN---------------TCLFTAFENE 302


                   ..
gi 1034591230  280 NK 281
Cdd:PHA02798   303 SK 304
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 474-721 5.99e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 40.90  E-value: 5.99e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  474 ESAKQDRLKLQNELAHKVAECKALALECERVK---EDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLtse 550
Cdd:COG4942     23 AEAEAELEQLQQEIAELEKELAALKKEEKALLkqlAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAEL--- 99

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  551 aasgnHRLTEELKDQLKDLkVKYEGASAEVGKLR----NQIKQNEMIVEEFKRDEGKLIEENKRLQKELSmcemerekkg 626
Cdd:COG4942    100 -----EAQKEELAELLRAL-YRLGRQPPLALLLSpedfLDAVRRLQYLKYLAPARREQAEELRADLAELA---------- 163

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  627 RKVTEMEGQAKELSAKLAlsipaeKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRE---LENVKAKLAQHVK 703
Cdd:COG4942    164 ALRAELEAERAELEALLA------ELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEaeeLEALIARLEAEAA 237

                          250
                   ....*....|....*...
gi 1034591230  704 PEEHEQVKSRLEQKSGEL 721
Cdd:COG4942    238 AAAERTPAAGFAALKGKL 255
TRPV3 cd22194
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a ...
 39-224 6.06e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a temperature-sensitive Transient Receptor Potential (TRP) ion channel that is activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants. TRPV3 function is regulated by physiological factors such as extracellular divalent cations and acidic pH, intracellular adenosine triphosphate, membrane voltage, and arachidonic acid. It is expressed in both neuronal and non-neuronal tissues including epidermal keratinocytes, epithelial cells in the gut, endothelial cells in blood vessels, and neurons in dorsal root ganglia and CNS. TRPV3 null mice have abnormal hair morphogenesis and compromised skin barrier function. It may play roles in inflammatory skin disorders, such as itch and pain sensation. TRPV3 is also expressed by many neuronal and non-neuronal tissues, showing that TRPV3 might play roles in other unknown cellular and physiological functions. TRPV3 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411978 [Multi-domain]  Cd Length: 680  Bit Score: 40.90  E-value: 6.06e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230   39 ECNWK-ISDHAADWNKYD--DRLMKAAErGDVEKVTSILAKKGV--NPGKLDVEGRSVFHVVTSKGNLE-CLNAILIHGV 112
Cdd:cd22194     28 PSNPNsPSAELAKEEQRDkkKRLKKVSE-AAVEELGELLKELKDlsRRRRKTDVPDFLMHKLTASDTGKtCLMKALLNIN 106

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  113 DITTSDTagRNALHLAAKYGhalCLQKLLqyNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHGASVNA---------K 183
Cdd:cd22194    107 ENTKEIV--RILLAFAEENG---ILDRFI--NAEYTEEAYEGQTALNIAIERRQGDIVKLLIAKGADVNAhakgvffnpK 179

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*..
gi 1034591230  184 DVD-----GRTPLVLATQMSRPTICQLLIDRGAD-VNSRDKQNRTAL 224
Cdd:cd22194    180 YKHegfyfGETPLALAACTNQPEIVQLLMEKESTdITSQDSRGNTVL 226
HEC1 COG5185
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
 786-1116 6.31e-03

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 41.10  E-value: 6.31e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  786 RKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLET-----VFVPPEKHEKEIIALKSNIVELKKQLSELK-KKCGEDQE 859
Cdd:COG5185    196 KKAEPSGTVNSIKESETGNLGSESTLLEKAKEIINIeealkGFQDPESELEDLAQTSDKLEKLVEQNTDLRlEKLGENAE 275

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  860 KIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNR-ELLDVKKKFEDINQEFVKikdKNEILKRNLENTQNQI 938
Cdd:COG5185    276 SSKRLNENANNLIKQFENTKEKIAEYTKSIDIKKATESLEEQlAAAEAEQELEESKRETET---GIQNLTAEIEQGQESL 352

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  939 KAEYISLaeheakmsslsqsmrKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKF 1018
Cdd:COG5185    353 TENLEAI---------------KEEIENIVGEVELSKSSEELDSFKDTIESTKESLDEIPQNQRGYAQEILATLEDTLKA 417

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1019 KATE-KELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIftlqkDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQ 1097
Cdd:COG5185    418 ADRQiEELQRQIEQATSSNEEVSKLLNELISELNKVMREA-----DEESQSRLEEAYDEINRSVRSKKEDLNEELTQIES 492

                          330
                   ....*....|....*....
gi 1034591230 1098 KYTEVKNVKEKLVEENAKQ 1116
Cdd:COG5185    493 RVSTLKATLEKLRAKLERQ 511
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 306-843 6.95e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 41.08  E-value: 6.95e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  306 VKSHQREHQNIQDLEIENEDLKERLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRT 385
Cdd:COG1196    294 LAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAE 373

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  386 IEALKNRFKYFESDHLgsgsHFSNRKEDMLLKQGQMYMADSQctspgipaHMQSRSMLRplelslpsqtsySENEILKKE 465
Cdd:COG1196    374 LAEAEEELEELAEELL----EALRAAAELAAQLEELEEAEEA--------LLERLERLE------------EELEELEEA 429

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  466 LEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKE 545
Cdd:COG1196    430 LAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEG 509

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  546 HLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQikqnemIVEEFKRDEGKLIEENKrlqkelsmcemeREKK 625
Cdd:COG1196    510 VKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAALQN------IVVEDDEVAAAAIEYLK------------AAKA 571

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  626 GRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPE 705
Cdd:COG1196    572 GRATFLPLDKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTL 651

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  706 EHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEmknhyvplkvSEDMKKSHDAIIDDLN 785
Cdd:COG1196    652 EGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEE----------ERELAEAEEERLEEEL 721

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1034591230  786 RKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVEL 843
Cdd:COG1196    722 EEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELERLEREIEAL 779
CCDC22 pfam05667
Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 ...
 771-1061 7.36e-03

Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 (CCDC22) is involved in regulation of NF-kappa-B signalling; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. It is part of the OMMD/CCDC22/CCDC93 (CCC) complex, which interacts with the multisubunit WASH complex required for endosomal deposition of F-actin and cargo trafficking in conjunction with the retromer. This entry also includes CCDC22 homologs from animals and plants.


Pssm-ID: 461708 [Multi-domain]  Cd Length: 600  Bit Score: 40.78  E-value: 7.36e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  771 EDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLlleNDSLSKDVSRLETVfvppekhEKEIIALKSNiVELKKQLSEL 850
Cdd:pfam05667  327 EELQQQREEELEELQEQLEDLESSIQELEKEIKKL---ESSIKQVEEELEEL-------KEQNEELEKQ-YKVKKKTLDL 395

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  851 KKKCGEDQEKIHALTSENTNLKKMMSNQY----VP-VKTHEEVKmtlndtLAKTNRELlDVKKKFEDINQEFVKIKDKNE 925
Cdd:pfam05667  396 LPDAEENIAKLQALVDASAQRLVELAGQWekhrVPlIEEYRALK------EAKSNKED-ESQRKLEEIKELREKIKEVAE 468

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  926 ILKRNlENTQNQIKAEYISLAeheaKMSSLSQSMRKVqdsnAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIkvky 1005
Cdd:pfam05667  469 EAKQK-EELYKQLVAEYERLP----KDVSRSAYTRRI----LEIVKNIKKQKEEITKILSDTKSLQKEINSLTGKL---- 535

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034591230 1006 apivsfeecERKFKATEKEL-----KDQLSEQTQKYSVSE----EEVKKNKQENDKLKKEIFTLQ 1061
Cdd:pfam05667  536 ---------DRTFTVTDELVfkdakKDESVRKAYKYLAALhencEQLIQTVEETGTIMREIRDLE 591
PLN03229 PLN03229
acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Provisional
 820-1220 7.74e-03

acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Provisional


Pssm-ID: 178768 [Multi-domain]  Cd Length: 762  Bit Score: 40.61  E-value: 7.74e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  820 ETVFVPPEK--HEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNlkKMMSnqyvpvKTHEEVKMTLNDTLa 897
Cdd:PLN03229   409 EGVPVDPERkvNMKKREAVKTPVRELEGEVEKLKEQILKAKESSSKPSELALN--EMIE------KLKKEIDLEYTEAV- 479

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  898 ktnrELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQ 977
Cdd:PLN03229   480 ----IAMGLQERLENLREEFSKANSQDQLMHPVLMEKIEKLKDEFNKRLSRAPNYLSLKYKLDMLNEFSRAKALSEKKSK 555

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  978 EEivTLHAEIKAQKKELDTIQEcikvkyapivsfeecerkFKATEKELKDQlseqtqkysVSEEEVKKNKQENDKLKKEI 1057
Cdd:PLN03229   556 AE--KLKAEINKKFKEVMDRPE------------------IKEKMEALKAE---------VASSGASSGDELDDDLKEKV 606

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1058 FTLQKDLRDKTVLIEKSHEMERALSRKTDelnkqlKDLSQKyTEVKNVKEKLVEENAKQTSEILAVQNLlqkqhvpleqv 1137
Cdd:PLN03229   607 EKMKKEIELELAGVLKSMGLEVIGVTKKN------KDTAEQ-TPPPNLQEKIESLNEEINKKIERVIRS----------- 668

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1138 ealkKSLNGTIENLKEEL-KSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVgiikASLREKEEESQN 1216
Cdd:PLN03229   669 ----SDLKSKIELLKLEVaKASKTPDVTEKEKIEALEQQIKQKIAEALNSSELKEKFEELEAEL----AAARETAAESNG 740


                   ....
gi 1034591230 1217 KMEE 1220
Cdd:PLN03229   741 SLKN 744
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 662-1344 7.77e-03

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 41.19  E-value: 7.77e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  662 EVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHvkpeeheqvksrlEQKSGELGKKITELTlkNQTLQKEIEK 741
Cdd:TIGR01612  531 DQNIKAKLYKEIEAGLKESYELAKNWKKLIHEIKKELEEE-------------NEDSIHLEKEIKDLF--DKYLEIDDEI 595

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  742 VYLdNKL---LKEQAHNltIEMKNHYVplKVSEDMKK---SHDAIIDDLNR--------KLLDVTQKYTEKKLEMEKLLl 807
Cdd:TIGR01612  596 IYI-NKLkleLKEKIKN--ISDKNEYI--KKAIDLKKiieNNNAYIDELAKispyqvpeHLKNKDKIYSTIKSELSKIY- 669

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  808 eNDSLSKDVSRLETVFvppekHEKEIialksNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKkmmsnqyvpVKTHEE 887
Cdd:TIGR01612  670 -EDDIDALYNELSSIV-----KENAI-----DNTEDKAKLDDLKSKIDKEYDKIQNMETATVELH---------LSNIEN 729

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  888 VKMTLNDTLAKTNRELldvkkkFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQ------SMRK 961
Cdd:TIGR01612  730 KKNELLDIIVEIKKHI------HGEINKDLNKILEDFKNKEKELSNKINDYAKEKDELNKYKSKISEIKNhyndqiNIDN 803

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  962 VQDSNAEilANYRKGQEEIVTLHA---EIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKElkdQLSEQTQKYsv 1038
Cdd:TIGR01612  804 IKDEDAK--QNYDKSKEYIKTISIkedEIFKIINEMKFMKDDFLNKVDKFINFENNCKEKIDSEHE---QFAELTNKI-- 876

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1039 seeevkKNKQENDKLKkeifTLQKDLRDKTVLIekshemeralsrktDELNKQLKDLSQKYTEVKNVKEKL-VEENAKQT 1117
Cdd:TIGR01612  877 ------KAEISDDKLN----DYEKKFNDSKSLI--------------NEINKSIEEEYQNINTLKKVDEYIkICENTKES 932

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1118 seilaVQNLLQKQHVpleqveaLKKSLNGTIENLKEElKSMQRCYEK--EQQTVTKLHQLLENQKNSSvpLAEHLQIKEA 1195
Cdd:TIGR01612  933 -----IEKFHNKQNI-------LKEILNKNIDTIKES-NLIEKSYKDkfDNTLIDKINELDKAFKDAS--LNDYEAKNNE 997

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1196 FEKEVGIIKASL-REKEEESQNKMEEVSKLQSEV-QNTKQALKKLETREVVDLSKYKATKSDLETQI----SSLNEKL-- 1267
Cdd:TIGR01612  998 LIKYFNDLKANLgKNKENMLYHQFDEKEKATNDIeQKIEDANKNIPNIEIAIHTSIYNIIDEIEKEIgkniELLNKEIle 1077

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1268 -ANLN-RKYEEVCEEVLH------AKKKEISAKDEKEllhfSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDN 1339
Cdd:TIGR01612 1078 eAEINiTNFNEIKEKLKHynfddfGKEENIKYADEIN----KIKDDIKNLDQKIDHHIKALEEIKKKSENYIDEIKAQIN 1153


                   ....*
gi 1034591230 1340 KITEL 1344
Cdd:TIGR01612 1154 DLEDV 1158
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 186-214 8.52e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 35.31  E-value: 8.52e-03
                           10        20
                   ....*....|....*....|....*....
gi 1034591230  186 DGRTPLVLATQMSRPTICQLLIDRGADVN 214
Cdd:pfam13606    1 DGNTPLHLAARNGRLEIVKLLLENGADIN 29
Gp58 pfam07902
gp58-like protein; Sequences found in this family are derived from a number of bacteriophage ...
 1067-1383 8.59e-03

gp58-like protein; Sequences found in this family are derived from a number of bacteriophage and prophage proteins. They are similar to gp58, a minor structural protein of Lactococcus delbrueckii bacteriophage LL-H.


Pssm-ID: 369586 [Multi-domain]  Cd Length: 594  Bit Score: 40.71  E-value: 8.59e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1067 KTVLIEKSHE-------MERALSrKTDELNKQLKDL--SQKYTEVK-NVKEKLVE-ENAKQTSEILAVQNLLQKQHVplE 1135
Cdd:pfam07902   63 APVVVEGSGEstglfksLEEMLS-QLKELNLELTDTknSNLWSKIKlNNNGMLREyHNDTIKTEIVESAEGIATRIS--E 139

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1136 QVEALKKSLNGTIENLKEELKSMQR-CYEKEQQTVTKLHQLLENQKNSsvplaehlqikeafekevgiikaslrekeees 1214
Cdd:pfam07902  140 DTDKKLALINETISGIRREYQDADRqLSSSYQAGIEGLKATMASDKIG-------------------------------- 187

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1215 qnkmeevskLQSEVQNTKQALKKLETREVVDLS-KYKATKSDletQISSLNEKLANLNRKYEEVCEEVLHAKKKEISA-K 1292
Cdd:pfam07902  188 ---------LQAEIQASAQGLSQRYDNEIRKLSaKITTTSSG---TTEAYESKLDDLRAEFTRSNQGMRTELESKISGlQ 255

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1293 DEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAkdnkitellndverLKQALNGL-SQLTYTSGNPTKR 1371
Cdd:pfam07902  256 STQQSTAYQISQEISNREGAVSRVQQDLDSYQRRLQDAEKNYSS--------------LTQTVKGLqSTVSDPNSKLESR 321

                          330
                   ....*....|..
gi 1034591230 1372 QSQLIDTLQHQV 1383
Cdd:pfam07902  322 ITQLAGLIEQKV 333
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
827-1108 8.65e-03

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 39.89  E-value: 8.65e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  827 EKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKmtlNDTLAKTNRELLDV 906
Cdd:COG1340     18 EELREEIEELKEKRDELNEELKELAEKRDELNAQVKELREEAQELREKRDELNEKVKELKEER---DELNEKLNELREEL 94

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  907 KKKFEDINQEFVKIKDKNEILKRnLENTQNQIKAEYISLAEHE---AKMSSLSQSMRKVQDSNaeilanyrKGQEEIVTL 983
Cdd:COG1340     95 DELRKELAELNKAGGSIDKLRKE-IERLEWRQQTEVLSPEEEKelvEKIKELEKELEKAKKAL--------EKNEKLKEL 165

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  984 HAEIKAQKKELDTIQECIKvkyapivsfeecerkfkatekelkdQLSEQTQKYSvseEEVKKNKQENDKLKKEIFTLQKD 1063
Cdd:COG1340    166 RAELKELRKEAEEIHKKIK-------------------------ELAEEAQELH---EEMIELYKEADELRKEADELHKE 217

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*
gi 1034591230 1064 LRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEK 1108
Cdd:COG1340    218 IVEAQEKADELHEEIIELQKELRELRKELKKLRKKQRALKREKEK 262
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 682-1240 9.07e-03

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 40.49  E-value: 9.07e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  682 SEIRQLKRELENVKAKLAQhvKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVyldNKLLKEQAHNLTIEMK 761
Cdd:pfam05557    2 AELIESKARLSQLQNEKKQ--MELEHKRARIELEKKASALKRQLDRESDRNQELQKRIRLL---EKREAEAEEALREQAE 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  762 NHYVPLKVSEDMKKshdaiiddlnrklldvtqKYTEKKLEMEKLLLENDSLSKDVSRLETVFvppEKHEKEIIALKSNIV 841
Cdd:pfam05557   77 LNRLKKKYLEALNK------------------KLNEKESQLADAREVISCLKNELSELRRQI---QRAELELQSTNSELE 135

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  842 ELKKQLSELKKKCGEDQEKIHALTSENTNLKkmmsnqyvpvkTHEEVKMTLNDTLAKTNRELLDVKkkfeDINQEFVKIK 921
Cdd:pfam05557  136 ELQERLDLLKAKASEAEQLRQNLEKQQSSLA-----------EAEQRIKELEFEIQSQEQDSEIVK----NSKSELARIP 200

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  922 DKNEILKRnlentqnqikaeyisLAEHEAKMSSLSQSMRKVQDSNAEI---LANYRKGQEEIVTLHAEIKAQKKELDTIQ 998
Cdd:pfam05557  201 ELEKELER---------------LREHNKHLNENIENKLLLKEEVEDLkrkLEREEKYREEAATLELEKEKLEQELQSWV 265

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230  999 ECIKVKYAPIVSFEECERKFKA---TEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSH 1075
Cdd:pfam05557  266 KLAQDTGLNLRSPEDLSRRIEQlqqREIVLKEENSSLTSSARQLEKARRELEQELAQYLKKIEDLNKKLKRHKALVRRLQ 345

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1076 EMERALSRKTDELNKQLKDLSQKYTEvKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEEL 1155
Cdd:pfam05557  346 RRVLLLTKERDGYRAILESYDKELTM-SNYSPQLLERIEEAEDMTQKMQAHNEEMEAQLSVAEEELGGYKQQAQTLEREL 424

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591230 1156 KSMQRCYE---------------KEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFE-KEVGIIKASLREKEEESQNKME 1219
Cdd:pfam05557  425 QALRQQESladpsyskeevdslrRKLETLELERQRLREQKNELEMELERRCLQGDYDpKKTKVLHLSMNPAAEAYQQRKN 504

                          570       580
                   ....*....|....*....|.
gi 1034591230 1220 EVSKLQSEVQNTKQALKKLET 1240
Cdd:pfam05557  505 QLEKLQAEIERLKRLLKKLED 525
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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