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Conserved domains on  [gi|768025620|ref|XP_011528645|]
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probable glucose sensor protein SLC5A4 isoform X2 [Homo sapiens]

Protein Classification

SLC5/6 family protein( domain architecture ID 124)

SLC5/6 (solute carrier 5/6) family protein may function as a transporter

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SLC5-6-like_sbd super family cl00456
Solute carrier families 5 and 6-like; solute binding domain; This superfamily includes the ...
 1-613 0e+00

Solute carrier families 5 and 6-like; solute binding domain; This superfamily includes the solute-binding domain of SLC5 proteins (also called the sodium/glucose cotransporters or solute sodium symporters), SLC6 proteins (also called the sodium- and chloride-dependent neurotransmitter transporters or Na+/Cl--dependent transporters), and nucleobase-cation-symport-1 (NCS1) transporters. SLC5s co-transport Na+ with sugars, amino acids, inorganic ions or vitamins. SLC6s include Na+/Cl--dependent plasma membrane transporters for the monoamine neurotransmitters serotonin, dopamine, and norepinephrine, and the amino acid neurotransmitters GABA and glycine. NCS1s are essential components of salvage pathways for nucleobases and related metabolites; their known substrates include allantoin, uracil, thiamine, and nicotinamide riboside. Members of this superfamily are important in human physiology and disease. They contain a functional core of 10 transmembrane helices (TMs): an inverted structural repeat, TMs1-5 and TMs6-10; TMs numbered to conform to the SLC6 Aquifex aeolicus LeuT.


The actual alignment was detected with superfamily member cd11486:

Pssm-ID: 444915  Cd Length: 636  Bit Score: 1000.99  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620   1 MLKTNRGTIGGFFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWTSSVMLLILGWIFVPIYIKSGVM 80
Cdd:cd11486   21 MVSTNRGTVGGFFLAGRSMVWWPIGASLFASNIGSGHFVGIAGTGAAAGIAIGGFEWNALVVVVVLGWLFVPIYIKAGVV 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620  81 TMPEYLKKRFGGERLQVYLSILSLFICVVLLISADIFAGAIFIKLALGLDLYLAIFILLAMTAVYTTTGGLASVIYTDTL 160
Cdd:cd11486  101 TMPEYLRKRFGGQRIQVYLSVLSLCLYIFTKISADIFSGAIFINLALGLNLYLAIVILLAITALYTITGGLAAVIYTDTL 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 161 QTIIMLIGSFILMGFAFNEVGGYESFTEKYVNATPSVVEGDNLTISASCYTPRADSFHIFRDAVTGDIPWPGIIFGMPIT 240
Cdd:cd11486  181 QTIIMVVGSFILMGFAFNEVGGYDAFMEKYMTAIPSVIGTGNSTSQEKCYTPRADSFHIFRDPITGDLPWPGLLFGLSIL 260

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 241 ALWYWCTNQVIVQRCLCGKDMSHVKAACIMCAYLKLLPMFLMVMPGMISRILYTDMVACVVPSECVKHCGVDVGCTNYAY 320
Cdd:cd11486  261 TLWYWCTDQVIVQRCLSAKNMSHVKAGCILCGYLKLLPMFIMVMPGMISRILYTDEIACVVPDECKAVCGTEVGCTNIAY 340

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 321 PTMVLELMPQGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKMRKQASEKELLIAGRIFVLLLTVVSIVWVPLVQV 400
Cdd:cd11486  341 PKLVVELMPNGLRGLMLSVMLASLMSSLTSIFNSASTLFTMDIYTKVRKKASEKELMIAGRLFMLVLIGISIAWVPIVQS 420

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 401 SQNGQLIHYTESISSYLGPPIAAVFVLAIFCKRVNEQGAFWGLMVGLAMGLIRMITEFAYGTGSCLAPSNCPKIICGVHY 480
Cdd:cd11486  421 AQSGQLFDYIQSITSYLGPPIAAVFLLAIFCKRVNEPGAFWGLCVGLLVGLARMITEFAYGTGSCVNPSNCPTIICGVHY 500

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 481 LYFSIVLFFGSMLVTLGISLLTKPIPDVHLYRLCWVLRNSTEERIDIDAEEKS-QEETDDGVEEDYPEKSRGCLKKAYDL 559
Cdd:cd11486  501 LYFAIILFGISCILILSISLMTKPIPDVHLYRLCWSLRNSKEERIDLDADDETeDQDSNSMIETDEMREEPGCCKKAYNW 580

                        570       580       590       600       610
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 768025620 560 FCGL--QKGPKLTKEEEEALSKKLTDTSERPSWRTIVNINAILLLAVVVFIHGYYA 613
Cdd:cd11486  581 FCGLdqGNAPKLTKEEEAALKMKLTDTSEKPLWRNVVNANGIILLTVAVFCHAFFA 636
 
Name Accession Description Interval E-value
SLC5sbd_SGLT1 cd11486
Na(+)/glucose cotransporter SGLT1;solute binding domain; Human SGLT1 (hSGLT1) is a ...
 1-613 0e+00

Na(+)/glucose cotransporter SGLT1;solute binding domain; Human SGLT1 (hSGLT1) is a high-affinity/low-capacity glucose transporter, which can also transport galactose. In the transport mechanism, two Na+ ions first bind to the extracellular side of the transporter and induce a conformational change in the glucose binding site. This results in an increased affinity for glucose. A second conformational change in the transporter follows, bringing the Na+ and glucose binding sites to the inner surface of the membrane. Glucose is then released, followed by the Na+ ions. In the process, hSGLT1 is also able to transport water and urea and may be a major pathway for transport of these across the intestinal brush-border membrane. hSGLT1 is encoded by the SLC5A1 gene and expressed mostly in the intestine, but also in the trachea, kidney, heart, brain, testis, and prostate. The WHO/UNICEF oral rehydration solution (ORS) for the treatment of secretory diarrhea contains salt and glucose. The glucose, along with sodium ions, is transported by hSGLT1 and water is either co-transported along with these or follows by osmosis. Mutations in SGLT1 are associated with intestinal glucose galactose malabsorption (GGM). Up-regulation of intestinal SGLT1 may protect against enteric infections. SGLT1 is expressed in colorectal, head and neck, and prostate tumors. Epidermal growth factor receptor (EGFR) functions in cell survival by stabilizing SGLT1, and thereby maintaining intracellular glucose levels. SGLT1 is predicted to have 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5)transporter family.


Pssm-ID: 271379  Cd Length: 636  Bit Score: 1000.99  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620   1 MLKTNRGTIGGFFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWTSSVMLLILGWIFVPIYIKSGVM 80
Cdd:cd11486   21 MVSTNRGTVGGFFLAGRSMVWWPIGASLFASNIGSGHFVGIAGTGAAAGIAIGGFEWNALVVVVVLGWLFVPIYIKAGVV 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620  81 TMPEYLKKRFGGERLQVYLSILSLFICVVLLISADIFAGAIFIKLALGLDLYLAIFILLAMTAVYTTTGGLASVIYTDTL 160
Cdd:cd11486  101 TMPEYLRKRFGGQRIQVYLSVLSLCLYIFTKISADIFSGAIFINLALGLNLYLAIVILLAITALYTITGGLAAVIYTDTL 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 161 QTIIMLIGSFILMGFAFNEVGGYESFTEKYVNATPSVVEGDNLTISASCYTPRADSFHIFRDAVTGDIPWPGIIFGMPIT 240
Cdd:cd11486  181 QTIIMVVGSFILMGFAFNEVGGYDAFMEKYMTAIPSVIGTGNSTSQEKCYTPRADSFHIFRDPITGDLPWPGLLFGLSIL 260

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 241 ALWYWCTNQVIVQRCLCGKDMSHVKAACIMCAYLKLLPMFLMVMPGMISRILYTDMVACVVPSECVKHCGVDVGCTNYAY 320
Cdd:cd11486  261 TLWYWCTDQVIVQRCLSAKNMSHVKAGCILCGYLKLLPMFIMVMPGMISRILYTDEIACVVPDECKAVCGTEVGCTNIAY 340

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 321 PTMVLELMPQGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKMRKQASEKELLIAGRIFVLLLTVVSIVWVPLVQV 400
Cdd:cd11486  341 PKLVVELMPNGLRGLMLSVMLASLMSSLTSIFNSASTLFTMDIYTKVRKKASEKELMIAGRLFMLVLIGISIAWVPIVQS 420

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 401 SQNGQLIHYTESISSYLGPPIAAVFVLAIFCKRVNEQGAFWGLMVGLAMGLIRMITEFAYGTGSCLAPSNCPKIICGVHY 480
Cdd:cd11486  421 AQSGQLFDYIQSITSYLGPPIAAVFLLAIFCKRVNEPGAFWGLCVGLLVGLARMITEFAYGTGSCVNPSNCPTIICGVHY 500

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 481 LYFSIVLFFGSMLVTLGISLLTKPIPDVHLYRLCWVLRNSTEERIDIDAEEKS-QEETDDGVEEDYPEKSRGCLKKAYDL 559
Cdd:cd11486  501 LYFAIILFGISCILILSISLMTKPIPDVHLYRLCWSLRNSKEERIDLDADDETeDQDSNSMIETDEMREEPGCCKKAYNW 580

                        570       580       590       600       610
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 768025620 560 FCGL--QKGPKLTKEEEEALSKKLTDTSERPSWRTIVNINAILLLAVVVFIHGYYA 613
Cdd:cd11486  581 FCGLdqGNAPKLTKEEEAALKMKLTDTSEKPLWRNVVNANGIILLTVAVFCHAFFA 636
SSF pfam00474
Sodium:solute symporter family; This family includes Swiss:P33413 which is not in the Prosite ...
 12-446 2.87e-163

Sodium:solute symporter family; This family includes Swiss:P33413 which is not in the Prosite entry. Membership of this family is supported by a significant blast score.


Pssm-ID: 109527 [Multi-domain]  Cd Length: 406  Bit Score: 472.59  E-value: 2.87e-163
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620   12 FFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWTSSVMLLILGWIFVPIYIKSGVMTMPEYLKKRFG 91
Cdd:pfam00474   1 YFLAGRSMTGFVNGLSLAASYMSAASFVGLAGAGAASGLAGGLYAIGALVGVWLLLWLFAPRLRNLGAYTMPDYLRKRFG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620   92 GERLQVYLSILSLFICVVLLISADIFAGAIFIKLALGLDLYLAIFILLAMTAVYTTTGGLASVIYTDTLQTIIMLIGSFI 171
Cdd:pfam00474  81 GKRILVYLSALSLLLYFFTYMSVQIVGGARLIELALGLNYYTAVLLLGALTAIYTFFGGFLAVSWTDTIQAVLMLFGTII 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620  172 LMGFAFNEVGGYESFTEKYVNATPSVVegDNLTisascytprADSFHIFRDAVTGDIPWPGIIFGMPITalwywctnQVI 251
Cdd:pfam00474 161 LMIIVFHEVGGYSSAVEKYMTADPNGV--DLYT---------PDGLHILRDPLTGLSLWPGLVLGTTGL--------PHI 221

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620  252 VQRCLCGKDmshvkAACIMCAYLKLLPMFLMVMPGMISRILYTDMVACVVPsecvKHCGVDVGCTNYAYPTMVLELMPQG 331
Cdd:pfam00474 222 LQRCLAAKD-----AKCIRCGVLILTPMFIIVMPGMISRGLFAIALAGANP----RACGTVVGCSNIAYPTLAVKLGPPG 292

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620  332 LRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKMRKQASEKELLIAGRIFVLLLTVVSIVWVPLVQVSQNGqLIHYTE 411
Cdd:pfam00474 293 LAGIMLAVMLAAIMSTLTSQLLSSSSAFTHDLYKNIRRKASATEKELVGRSRIIVLVVISLAILLAVQPAQMG-IAFLVQ 371

                         410       420       430
                  ....*....|....*....|....*....|....*
gi 768025620  412 SISSYLGPPIAAVFVLAIFCKRVNEQGAFWGLMVG 446
Cdd:pfam00474 372 LAFAGLGSAFLPVILLAIFWKRVNEQGALWGMIIG 406
sss TIGR00813
transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the ...
 15-446 6.45e-158

transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the SSS family catalyze solute:Na+ symport. The solutes transported may be sugars, amino acids, nucleosides, inositols, vitamins, urea or anions, depending on the system. Members of the SSS family have been identified in bacteria, archaea and animals, and all functionally well characterized members catalyze solute uptake via Na+ symport. Proteins of the SSS generally share a core of 13 TMSs, but different members of the family may have different numbers of TMSs. A 13 TMS topology with a periplasmic N-terminus and a cytoplasmic C-terminus has been experimentally determined for the proline:Na+ symporter, PutP, of E. coli. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273282 [Multi-domain]  Cd Length: 407  Bit Score: 458.69  E-value: 6.45e-158
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620   15 AGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWTSSVMLLILGWIFVPIYIKSGVMTMPEYLKKRFGGeR 94
Cdd:TIGR00813   1 AGRSLGGWVVAASLFASYISASQFLGLPGAIYAYGFAIGFYELGALVLLIILGWLFVPIFINNGAYTMPEYLEKRFGK-R 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620   95 LQVYLSILSLFICVVLLISADIFAGAIFIKLALGLDLYLAIFILLAMTAVYTTTGGLASVIYTDTLQTIIMLIGSFILMG 174
Cdd:TIGR00813  80 ILRGLSVLSLILYIFLYMSVDLFSGALLIELITGLDLYLSLLLLGAITILYTVFGGLKAVVWTDTIQAVIMILGTFILPV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620  175 FAFNEVGGYESFTEKYVNATPSVvegdnltisascyTPRADSFHIFRDAVTGDIPWPGIIFGMPITALWYWcTNQVIVQR 254
Cdd:TIGR00813 160 FAFSEVGGLGTFVEKASQAAPTN-------------PSPDDLYDFFRDPSTSDLPWGAGVFGLPHVALWYW-TNQVIVQR 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620  255 CLCGKDMSHVKAACIMCAYLKLLPMFLMVMPGMISRILYTDMvacvVPSEcvkhCGVDVGCTNYAYPTMVLELMPQGLRG 334
Cdd:TIGR00813 226 CLAAKSAKHAKKGCLISGVLKLLPMFGAVLPGLIARALYTDI----DPAL----AGAVNQNSDQAYPLLVQELMPPGLAG 297

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620  335 LMLSVMLASLMSSLTSIFNSASTLFTIDLYTKMRKQASEKELLIAGRIFVLLLTVVSIVWVplVQVSQNGQLIHYTESIS 414
Cdd:TIGR00813 298 LFLAAILAAVMSTLSSQLNSASTVFTMDLYKKIIRPNASGEKKIVMRGRIAVLVAAVIAGF--VAAAQGGQVLQYVQEAF 375

                         410       420       430
                  ....*....|....*....|....*....|..
gi 768025620  415 SYLGPPIAAVFVLAIFCKRVNEQGAFWGLMVG 446
Cdd:TIGR00813 376 GGLGAPFLPVFLLGIFWKRMNAKGALAGMIAG 407
YidK COG4146
Uncharacterized membrane permease YidK, sodium:solute symporter family [General function ...
 3-453 8.19e-140

Uncharacterized membrane permease YidK, sodium:solute symporter family [General function prediction only];


Pssm-ID: 443317 [Multi-domain]  Cd Length: 444  Bit Score: 413.77  E-value: 8.19e-140
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620   3 KTNRGTIGGFFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWTSSVMLLILGWIFVPIYIKSGVMTM 82
Cdd:COG4146   28 KKKEKTSEDYFLAGRSLTWWVIGASLIATNISAEQLIGLNGSGYATGLAVAAYEWMAAIALIILALFFLPFYLKSGIYTM 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620  83 PEYLKKRFgGERLQVYLSILSLFICVVLLISADIFAGAIFIKLALGLDLYLAIFILLAMTAVYTTTGGLASVIYTDTLQT 162
Cdd:COG4146  108 PEFLEKRY-DRRTRTILSILFLVSYVFVNLPSVLYAGALALNTIFGVPLWISVIGLGIIAGIYTIFGGLKAVAYTDVIQG 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 163 IIMLIGSFILMGFAFNEVGGyesftekyvnatPSVVEG-DNLTISAscytprADSFHIFRDAVTGDIPWPGIIFGMPITA 241
Cdd:COG4146  187 IGLIIGGLLITVLGLDAVGD------------GSVLAGwSALLKVP------PEKFNMIGPADDPDLPWLGIFTGMPILN 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 242 LWYWCTNQVIVQRCLCGKDMSHVKAACIMCAYLKLLPMFLMVMPGMISRILYTDMVAcvvpsecvkhcgvdvgCTNYAYP 321
Cdd:COG4146  249 LFYWGTNQYIVQRALGAKNLKEAQKGVLFAGFLKLLIPFIVVLPGIIAFVLFPDGLD----------------NPDQAYP 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 322 TMVLELMPQGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKM-RKQASEKELLIAGRIFVLLLTVVSIVWVPLVQV 400
Cdd:COG4146  313 TLVKNLLPVGLKGLVAAALFAAIMSSLASALNSSSTLFTLDIYKKYfNPNASEKQLVKVGRIATVVLAVIAILIAPLIGN 392

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|...
gi 768025620 401 SqnGQLIHYTESISSYLGPPIAAVFVLAIFCKRVNEQGAFWGLMVGLAMGLIR 453
Cdd:COG4146  393 A--DGLFQYIQEVTGFFSPPILAVFLLGLFWKRVTAKAAKVALIAGIVLSILL 443
PRK10484 PRK10484
putative transporter; Provisional
 3-501 7.78e-68

putative transporter; Provisional


Pssm-ID: 236699 [Multi-domain]  Cd Length: 523  Bit Score: 229.77  E-value: 7.78e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620   3 KTNRGTIGGFFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWTSSVMLLILGWIFVPIYIKSGVMTM 82
Cdd:PRK10484  24 KTDTSSSDGYFLAGRSLTGPVIAGSLLLTNLSTEQLVGLNGQAYASGMSVMAWEVTAAIALIILALIFLPRYLKSGITTI 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620  83 PEYLKKRFGGERLQVyLSILSLFICVVLLISADIFAGAI-----F-IKLALGLDLYLAIFILLAMT----AVYTTTGGLA 152
Cdd:PRK10484 104 PDFLEERYDKTTRRI-VSILFLIGYVVSFLPIVLYSGALalnslFhVSELLGISYGAAIWLLVWLIgiigAIYAVFGGLK 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 153 SVIYTDTLQTIIMLIGSFILMGFAFNEVGGyesftekyvnatpsvveGDNLTISASCYTPRADSFHIFRDAvTGDIPWPG 232
Cdd:PRK10484 183 AVAVSDTINGIGLLIGGLLVPVFGLIALGD-----------------GSFMQGLEQLTTVHPEKLNSIGGA-TDPVPFPT 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 233 IIFGMPITALWYWCTNQVIVQRCLCGKDMSHVKAACIMCAYLKLLPMFLMVMPGMISRILYTDMVACvvpsecvkhcgvd 312
Cdd:PRK10484 245 LFTGLILVNLFYWCTNQSIVQRALGAKNLAEGQKGALLAAFFKLLGPLILVLPGIIAFHLYGDGLPN------------- 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 313 vgcTNYAYPTMVLELMPQGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLY-TKMRKQASEKELLIAGRIFVLLLTVVS 391
Cdd:PRK10484 312 ---ADMAYPTLVNDVLPVPLVGFFAAVLFGAILSTFNGFLNSASTLFSLDIYkPIINPNASEKQLVKVGKKFGFVLAIIS 388

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 392 IVWVPLVQVSQNGqLIHYTESISSYLGPPIAAVFVLAIFCKRVNEQGAFWGLMVG-LAMGLIRMITEFaygtgsclapsn 470
Cdd:PRK10484 389 MIVAPLIANAPQG-LYSYLQQLNGIYNVPILAIIIVGFFTKRVPALAAKVALGFGiILYIIINFVLKF------------ 455

                        490       500       510
                 ....*....|....*....|....*....|.
gi 768025620 471 cpkiicGVHYLYFSIVLFFGSMLVTLGISLL 501
Cdd:PRK10484 456 ------DIHFLYVLAILFVINVVVMLIIGKI 480
 
Name Accession Description Interval E-value
SLC5sbd_SGLT1 cd11486
Na(+)/glucose cotransporter SGLT1;solute binding domain; Human SGLT1 (hSGLT1) is a ...
 1-613 0e+00

Na(+)/glucose cotransporter SGLT1;solute binding domain; Human SGLT1 (hSGLT1) is a high-affinity/low-capacity glucose transporter, which can also transport galactose. In the transport mechanism, two Na+ ions first bind to the extracellular side of the transporter and induce a conformational change in the glucose binding site. This results in an increased affinity for glucose. A second conformational change in the transporter follows, bringing the Na+ and glucose binding sites to the inner surface of the membrane. Glucose is then released, followed by the Na+ ions. In the process, hSGLT1 is also able to transport water and urea and may be a major pathway for transport of these across the intestinal brush-border membrane. hSGLT1 is encoded by the SLC5A1 gene and expressed mostly in the intestine, but also in the trachea, kidney, heart, brain, testis, and prostate. The WHO/UNICEF oral rehydration solution (ORS) for the treatment of secretory diarrhea contains salt and glucose. The glucose, along with sodium ions, is transported by hSGLT1 and water is either co-transported along with these or follows by osmosis. Mutations in SGLT1 are associated with intestinal glucose galactose malabsorption (GGM). Up-regulation of intestinal SGLT1 may protect against enteric infections. SGLT1 is expressed in colorectal, head and neck, and prostate tumors. Epidermal growth factor receptor (EGFR) functions in cell survival by stabilizing SGLT1, and thereby maintaining intracellular glucose levels. SGLT1 is predicted to have 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5)transporter family.


Pssm-ID: 271379  Cd Length: 636  Bit Score: 1000.99  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620   1 MLKTNRGTIGGFFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWTSSVMLLILGWIFVPIYIKSGVM 80
Cdd:cd11486   21 MVSTNRGTVGGFFLAGRSMVWWPIGASLFASNIGSGHFVGIAGTGAAAGIAIGGFEWNALVVVVVLGWLFVPIYIKAGVV 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620  81 TMPEYLKKRFGGERLQVYLSILSLFICVVLLISADIFAGAIFIKLALGLDLYLAIFILLAMTAVYTTTGGLASVIYTDTL 160
Cdd:cd11486  101 TMPEYLRKRFGGQRIQVYLSVLSLCLYIFTKISADIFSGAIFINLALGLNLYLAIVILLAITALYTITGGLAAVIYTDTL 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 161 QTIIMLIGSFILMGFAFNEVGGYESFTEKYVNATPSVVEGDNLTISASCYTPRADSFHIFRDAVTGDIPWPGIIFGMPIT 240
Cdd:cd11486  181 QTIIMVVGSFILMGFAFNEVGGYDAFMEKYMTAIPSVIGTGNSTSQEKCYTPRADSFHIFRDPITGDLPWPGLLFGLSIL 260

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 241 ALWYWCTNQVIVQRCLCGKDMSHVKAACIMCAYLKLLPMFLMVMPGMISRILYTDMVACVVPSECVKHCGVDVGCTNYAY 320
Cdd:cd11486  261 TLWYWCTDQVIVQRCLSAKNMSHVKAGCILCGYLKLLPMFIMVMPGMISRILYTDEIACVVPDECKAVCGTEVGCTNIAY 340

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 321 PTMVLELMPQGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKMRKQASEKELLIAGRIFVLLLTVVSIVWVPLVQV 400
Cdd:cd11486  341 PKLVVELMPNGLRGLMLSVMLASLMSSLTSIFNSASTLFTMDIYTKVRKKASEKELMIAGRLFMLVLIGISIAWVPIVQS 420

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 401 SQNGQLIHYTESISSYLGPPIAAVFVLAIFCKRVNEQGAFWGLMVGLAMGLIRMITEFAYGTGSCLAPSNCPKIICGVHY 480
Cdd:cd11486  421 AQSGQLFDYIQSITSYLGPPIAAVFLLAIFCKRVNEPGAFWGLCVGLLVGLARMITEFAYGTGSCVNPSNCPTIICGVHY 500

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 481 LYFSIVLFFGSMLVTLGISLLTKPIPDVHLYRLCWVLRNSTEERIDIDAEEKS-QEETDDGVEEDYPEKSRGCLKKAYDL 559
Cdd:cd11486  501 LYFAIILFGISCILILSISLMTKPIPDVHLYRLCWSLRNSKEERIDLDADDETeDQDSNSMIETDEMREEPGCCKKAYNW 580

                        570       580       590       600       610
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 768025620 560 FCGL--QKGPKLTKEEEEALSKKLTDTSERPSWRTIVNINAILLLAVVVFIHGYYA 613
Cdd:cd11486  581 FCGLdqGNAPKLTKEEEAALKMKLTDTSEKPLWRNVVNANGIILLTVAVFCHAFFA 636
SLC5sbd_SGLT2 cd11487
Na(+)/glucose cotransporter SGLT2 and related proteins; solute-binding domain; Human SGLT2 ...
 1-613 0e+00

Na(+)/glucose cotransporter SGLT2 and related proteins; solute-binding domain; Human SGLT2 (hSGLT2) is a high-capacity, low-affinity glucose transporter, that plays an important role in renal glucose reabsorption. It is encoded by the SLC5A2 gene and expressed almost exclusively in renal proximal tubule cells. Mutations in hSGLT2 cause Familial Renal Glucosuria (FRG), a rare autosomal defect in glucose transport. hSGLT2 is a major drug target for regulating blood glucose levels in diabetes. hSGLT2 is predicted to have 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 212056 [Multi-domain]  Cd Length: 583  Bit Score: 770.24  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620   1 MLKTNRGTIGGFFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWTSSVMLLILGWIFVPIYIKSGVM 80
Cdd:cd11487   21 MCRTNRGTVGGYFLAGRSMVWWPVGASLFASNIGSGHFVGLAGTGAASGIAVAGFEWNALFVVLLLGWLFVPVYLTAGVI 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620  81 TMPEYLKKRFGGERLQVYLSILSLFICVVLLISADIFAGAIFIKLALGLDLYLAIFILLAMTAVYTTTGGLASVIYTDTL 160
Cdd:cd11487  101 TMPQYLKKRFGGQRIRLYLSVLSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIALLGITMIYTVTGGLAALMYTDTV 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 161 QTIIMLIGSFILMGFAFNEVGGYESFTEKYVNATPSVVEGDNLT---ISASCYTPRADSFHIFRDAVTGDIPWPGIIFGM 237
Cdd:cd11487  181 QTFVIIGGACVLMGYAFHEVGGYSALFEKYLKAVPSLTVSEDPAvgnISSSCYRPRPDSYHLLRDPVTGDLPWPALILGL 260

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 238 PITALWYWCTNQVIVQRCLCGKDMSHVKAACIMCAYLKLLPMFLMVMPGMISRILYTDMVACVVPSECVKHCGVDVGCTN 317
Cdd:cd11487  261 TIVSSWYWCSDQVIVQRCLAARSLTHVKAGCILCGYLKLLPMFLMVMPGMISRVLYPDEVACVEPSVCLRVCGTEVGCSN 340

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 318 YAYPTMVLELMPQGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKMRKQASEKELLIAGRIFVLLLTVVSIVWVPL 397
Cdd:cd11487  341 IAYPKLVVKLMPNGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIWTRLRPQAGDKELLLVGRVWVVCIVAVSVAWIPV 420

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 398 VQVSQNGQLIHYTESISSYLGPPIAAVFVLAIFCKRVNEQGAFWGLMVGLAMGLIRMITEFAYGTGSCLAPSNCPKIICG 477
Cdd:cd11487  421 VQAAQGGQLFDYIQSVSSYLAPPIAAVFFLALFVKRVNEPGAFWGLIGGLLMGLCRMVPEFSFGSGSCVAPSSCPAIICG 500

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 478 VHYLYFSIVLFFGSMLVTLGISLLTKPIPDVHLYRLCWVLRNSTEERIDIdaeeksqeetddgveedypeksrgclkkay 557
Cdd:cd11487  501 VHYLYFAILLFFCSGLLVLIVSLCTPPIPRKHLHRLVFSLRHSKEEREDL------------------------------ 550

                        570       580       590       600       610
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 768025620 558 dlfcglqkgpkltkeeeealskkLTDTSERPSWRTIVNINAILLLAVVVFIHGYYA 613
Cdd:cd11487  551 -----------------------LPDISEDPKWARVVNLNALIMMAVAVFLWGFYA 583
SLC5sbd_SGLT4 cd11488
Na(+)/glucose cotransporter SGLT4 and related proteins; solute-binding domain; Human SGLT4 ...
 2-613 0e+00

Na(+)/glucose cotransporter SGLT4 and related proteins; solute-binding domain; Human SGLT4 (hSGLT4) has been reported to be a low-affinity glucose transporter with unusual sugar selectivity: it transports D-mannose but not galactose or 3-O-methyl-D-glucoside. It is encoded by the SLC5A9 gene and is expressed in intestine, kidney, liver, brain, lung, trachea, uterus, and pancreas. hSLGT4 is predicted to contain 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5 )transporter family.


Pssm-ID: 271380  Cd Length: 605  Bit Score: 739.05  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620   2 LKTNRGTIGGFFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWTSSVMLLILGWIFVPIYIKSGVMT 81
Cdd:cd11488   21 IRASRGTVGGYFLAGRSMTWWPIGASLMSSNVGSGLFIGLAGTGAAGGLAVGGFEWNAAWVLIALGWIFVPVYIAAGVVT 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620  82 MPEYLKKRFGGERLQVYLSILSLFICVVLLISADIFAGAIFIKLALGLDLYLAIFILLAMTAVYTTTGGLASVIYTDTLQ 161
Cdd:cd11488  101 MPEYLKKRFGGQRIRIYMSVLSLILYIFTKISTDIFSGALFIQVSLGWNLYLSTVILLAVTALYTIAGGLTAVIYTDALQ 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 162 TIIMLIGSFILMGFAFNEVGGYESFTEKYVNATPsvvegdNLTI-SASCYTPRADSFHIFRDAVTGDIPWPGIIFGMPIT 240
Cdd:cd11488  181 TVIMVIGAFVLMFIAFDKVGWYPGLEQQYEKAIP------ALTVpNTTCHLPRSDAFHIFRDPVTGDIPWPGLIFGLTVL 254

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 241 ALWYWCTNQVIVQRCLCGKDMSHVKAACIMCAYLKLLPMFLMVMPGMISRILYTDMVACVVPSECVKHCGVDVGCTNYAY 320
Cdd:cd11488  255 ATWVWCTDQVIVQRSLSAKNLSHAKGGSVLGGYLKILPMFFVVMPGMISRALFPDEVGCVDPDECQKICGAKVGCSNIAY 334

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 321 PTMVLELMPQGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKMRKQASEKELLIAGRIFVLLLTVVSIVWVPLVQV 400
Cdd:cd11488  335 PKLVVELMPVGLRGLMIAVIMAALMSSLTSIFNSSSTLFTMDVWQRIRRRASEQELMVVGRVFILLLVVISILWIPIIQT 414

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 401 SQNGQLIHYTESISSYLGPPIAAVFVLAIFCKRVNEQGAFWGLMVGLAMGLIRMITEFAYGTGSCLAPSNCPKIICGVHY 480
Cdd:cd11488  415 ANSGQLFDYIQAVTSYLSPPITAVFILAIFWKRVNEPGAFWGLMVGLVVGLVRMIMEFVYGAPSCGETDLRPSVLKDVHY 494

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 481 LYFSIVLFFGSMLVTLGISLLTKPIPDVHLYRLCWVLRNSTEERIDIdaeeksqeetddgveedypeksrgCLKKAYDLF 560
Cdd:cd11488  495 LYFAIILLGLTAIVIVAVSLCTAPIPEKHLVRLTWWTRNSPEERVEL------------------------WWKRLGMWF 550

                        570       580       590       600       610
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 768025620 561 CGLQKGPK--LTKEEEEALSKKLTDTSERPSWRTIVNINAILLLAVVVFIHGYYA 613
Cdd:cd11488  551 CGLSQTPEqdLSEEERQALEKKLTSIEEDPLWRTVCNINALILLAINVFLWGYFA 605
SLC5sbd_SGLT1-like cd10329
Na(+)/glucose cotransporter SGLT1 and related proteins; solute binding domain; This subfamily ...
 4-613 0e+00

Na(+)/glucose cotransporter SGLT1 and related proteins; solute binding domain; This subfamily includes the solute-binding domain of SGLT proteins that cotransport Na+ with various solutes. Its members include: the human glucose (SGLT1, -2, -4, -5 ), chiro-inositol (SGLT5), and myo-inositol (SMIT) cotransporters. It also includes human SGLT3 which has been characterized as a glucose sensor and not a transporter. It belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271363  Cd Length: 538  Bit Score: 724.75  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620   4 TNRGTIGGFFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWTSSVMLLILGWIFVPIYIKSGVMTMP 83
Cdd:cd10329   21 KKRSTVSGYFLAGRSMGWPVIGASLFASNIGSSHLVGLAGSGAASGIAVGNYEWNAAFVLLLLGWVFLPFYIRSGVSTMP 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620  84 EYLKKRFGGeRLQVYLSILSLFICVVLLISADIFAGAIFIKLALGLDLYLAIFILLAMTAVYTTTGGLASVIYTDTLQTI 163
Cdd:cd10329  101 EFLEKRFGG-RSRVYLSVLSLILYVFTKISVDLYAGALVIKQLLGWDLYLSIIVLLVITAIYTIAGGLKAVIYTDTLQAV 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 164 IMLIGSFILMGFAFNEVGGyesFTEKYVNATPSVVegdnltisascytpradSFHIFRDAVTGDIPWPGIIFGMPITALW 243
Cdd:cd10329  180 ILIIGSAILMFLAFNEVGG---GWSAYMAAIPSGT-----------------AFHLFRPPDDPDLPWPGLLLGYPILGIW 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 244 YWCTNQVIVQRCLCGKDMSHVKAACIMCAYLKLLPMFLMVMPGMISRILYTDMVACVVPsecvkhCGVDVGCTNYAYPTM 323
Cdd:cd10329  240 YWCTDQVIVQRVLAAKNLKHARRGALFAGYLKLLPLFLMVLPGMIARALFPDLVACVVP------CGNGVGCSDIAYPTL 313

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 324 VLELMPQGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKMRKQASEKELLIAGRIFVLLLTVVSIVWVPLVQvSQN 403
Cdd:cd10329  314 VTELLPVGLRGLVLAVLLAALMSSLTSIFNSASTLFTMDIYKRLRPEASEKELVRVGRIATLVVVVISILWAPIIQ-AQG 392

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 404 GQLIHYTESISSYLGPPIAAVFVLAIFCKRVNEQGAFWGLMVGLAMGLIRMITEFAYGtgsclAPSNCPKIICGVHYLYF 483
Cdd:cd10329  393 GSLFNYIQSVLSYLAPPIAAVFLLGIFWKRTNEQGAFWGLIAGLVLGLVRLILEFAYG-----EPDTRPAIIGGIHFLYF 467

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 484 SIVLFFGSMLVTLGISLLTKPIPDVHLYRLCWVLRnsteerididaeeksqeetddgveedypeksrgclkkaydlfcgl 563
Cdd:cd10329  468 AFLLFVVSVIVTVIVSLLTPPPPAEKLAGLTWSTR--------------------------------------------- 502

                        570       580       590       600       610
                 ....*....|....*....|....*....|....*....|....*....|
gi 768025620 564 qkgpkltkeeeealSKKLTDTSERPSWRTIVNINAILLLAVVVFIHGYYA 613
Cdd:cd10329  503 --------------LTKETSTLERPPWYKNVRILAILLLALTIFLYGYFA 538
SLC5sbd_SGLT6 cd11490
Na(+)/chiro-inositol cotransporter SGLT6 and related proteins; solute-binding domain; Human ...
 1-613 0e+00

Na(+)/chiro-inositol cotransporter SGLT6 and related proteins; solute-binding domain; Human SGLT6 (also called KST1, SMIT2) is a chiro-inositol transporter, which also transports myo-inositol. It is encoded by the SLC5A11 gene. Xenopus Na1-glucose cotransporter type 1 (SGLT-1)-like protein is predicted to contain 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271381  Cd Length: 602  Bit Score: 682.02  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620   1 MLKTNRGTIGGFFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWTSSVMLLILGWIFVPIYIKSGVM 80
Cdd:cd11490   20 MWKTKRSTVKGYFLAGKDMTWWPVGASLFASNVGSGHFIGLAGSGAAAGIGVVAYEWNGLFMVLVLAWLFLPIYIASRVT 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620  81 TMPEYLKKRFGGERLQVYLSILSLFICVVLLISADIFAGAIFIKLALGLDLYLAIFILLAMTAVYTTTGGLASVIYTDTL 160
Cdd:cd11490  100 TMPEYLKKRFGGKRIQIFLAVLYLFIYIFTKISVDMYAGAVFIQQALQWDLYLAVVGLLGITALYTVAGGLAAVIYTDAL 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 161 QTIIMLIGSFILMGFAFNEVGGYESFTEKYVNATPSVVEGDnltisASCYTPRADSFHIFRDAVTGDIPWPGIIFGMPIT 240
Cdd:cd11490  180 QTIIMVIGALILMGYSFAEVGGFEALLEKYFQAIPSIRSPN-----STCGIPREDAFHIFRDPVTSDLPWPGVLLGMSIP 254

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 241 ALWYWCTNQVIVQRCLCGKDMSHVKAACIMCAYLKLLPMFLMVMPGMISRILYTDMVACVVPSECVKHCGVDVGCTNYAY 320
Cdd:cd11490  255 SLWYWCTDQVIVQRSLAAKNLSHAKGGSLLAAYLKVLPLFMMVIPGMISRILFPDQVACADPEVCKEICGNPSGCSDIAY 334

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 321 PTMVLELMPQGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKMRKQASEKELLIAGRIFVLLLTVVSIVWVPLVQV 400
Cdd:cd11490  335 PKLVMELLPTGLRGLMMAVMLAALMSSLTSIFNSASTIFTMDLWRHIRPRASEWELMIVGRVFVLVLVVVSILWIPLVQA 414

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 401 SQNGQLIHYTESISSYLGPPIAAVFVLAIFCKRVNEQGAFWGLMVGLAMGLIRMITEFAYGTGSCLAPSNCPKIICGVHY 480
Cdd:cd11490  415 SQGGQLFIYIQSISSYLQPPVAVVFIAGCFWKRTNEKGAFWGLMVGLAVGLTRMVLDFIYVTPQCDQPDTRPDIVKYVHY 494

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 481 LYFSIVLFFGSMLVTLGISLLTKPIPDVHLYRLCWVLRnsteeridIDAEEKSQEetddgveedypeksrgcLKKAYDLF 560
Cdd:cd11490  495 LYFSMILTILTLVVVVCVSLATEPPSKEMISRLTWFTR--------FDAVVESEE-----------------LKKAILWL 549

                        570       580       590       600       610
                 ....*....|....*....|....*....|....*....|....*....|...
gi 768025620 561 CGLQKGPKLTKEEEEALSKKLTDTSERPSWRTIVNINAILLLAVVVFIHGYYA 613
Cdd:cd11490  550 CGMEKQTEKSSSSPAPPEAAMVSLEEEPLMKHVLNANLIICVSVAVFLWAYFA 602
SLC5sbd_SGLT5 cd11489
Na(+)/glucose cotransporter SGLT5 and related proteins; solute-binding domain; Human SGLT5 is ...
 3-613 0e+00

Na(+)/glucose cotransporter SGLT5 and related proteins; solute-binding domain; Human SGLT5 is a glucose transporter, which also transports galactose. It is encoded by the SLC5A10 gene, and is exclusively expressed in the renal cortex. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 212058  Cd Length: 604  Bit Score: 667.80  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620   3 KTNRGTIGGFFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWTSSVMLLILGWIFVPIYIKSGVMTM 82
Cdd:cd11489   25 RVSRNTVSGYFLAGRDMAWWPIGASLFASSEGSGLFIGLAGTGAAGGIAVAGFEWNATYALLALAWVFVPVYISSGIVTM 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620  83 PEYLKKRFGGERLQVYLSILSLFICVVLLISADIFAGAIFIKLALGLDLYLAIFILLAMTAVYTTTGGLASVIYTDTLQT 162
Cdd:cd11489  105 PEYLQRRFGGERIRMYLSVLSLLLSVFTKISTDLYSGALFVQVCLGWNLYLSTVLMLVVTALYTIAGGLAAVIYTDALQT 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 163 IIMLIGSFILMGFAFNEVGGYESFTEKYVNATPSvvegdNLTISASCYTPRADSFHIFRDAVTGDIPWPGIIFGMPITAL 242
Cdd:cd11489  185 LIMVIGAVILTIKAFNQIGGYSNLEEAYLQAVPS-----KIIPNTTCHLPRADAMHLFRDPVTGDLPWTGMTFGLTIMAT 259

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 243 WYWCTNQVIVQRCLCGKDMSHVKAACIMCAYLKLLPMFLMVMPGMISRILYTDMVACVVPSECVKHCGVDVGCTNYAYPT 322
Cdd:cd11489  260 WYWCTDQVIVQRSLSARSLSHAKGGSILASYLKMLPMGLIIMPGMISRALFPDDVACVDPEECLRVCGAEVGCSNIAYPK 339

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 323 MVLELMPQGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKMRKQASEKELLIAGRIFVLLLTVVSIVWVPLVQVSQ 402
Cdd:cd11489  340 LVMELMPSGLRGLMIAVMMAALMSSLTSIFNSSSTLFTMDIWRRLRPGASERELLLVGRLVTVILVGVSVVWIPILQSSN 419

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 403 NGQLIHYTESISSYLGPPIAAVFVLAIFCKRVNEQGAFWGLMVGLAMGLIRMITEFAYGTGSCLAPSNCPKIICGVHYLY 482
Cdd:cd11489  420 SGQLYIYIQSVTSYLAPPVTAVFVLAVFWRRANEQGAFWGLMAGLVVGLTRMVLEFAHPAPRCGVPDTRPSVLRSMHYLH 499

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 483 FSIVLFFGSMLVTLGISLLTKPIPDVHLYRLC-WVLRNSTEerididaeeksqEETDDGVEEDYPEKSRGCLKKAYDLFC 561
Cdd:cd11489  500 FAVALCALSGAVVVAGSLLTPPPQSVQIRNLTwWTLAQDTP------------LGIKLGDGQTLSRRTDGCESVRFASGT 567

                        570       580       590       600       610
                 ....*....|....*....|....*....|....*....|....*....|..
gi 768025620 562 GLqkgpkltkeeeealsKKLTDTSERPSWRTIVNINAILLLAVVVFIHGYYA 613
Cdd:cd11489  568 PP---------------PIIHSTTEHPFWARVCGVNAILLMCVNIFFYAYFA 604
SLC5sbd_SMIT cd11491
Na(+)/myo-inositol cotransporter SMIT and related proteins; solute-binding domain; Human SMIT ...
 1-520 0e+00

Na(+)/myo-inositol cotransporter SMIT and related proteins; solute-binding domain; Human SMIT is a high-affinity myo-inositol transporter, and is expressed in brain, heart, kidney, and lung. Inhibition of myo-inositol uptake, through down-regulation of SMIT, may be a common mechanism of action of mood stabilizers, including lithium, carbamazepine, and valproate. SMIT is encoded by the SLC5A3 gene, which is a candidate gene for pathogenesis of nervous system dysfunction in Down syndrome (DS). The SNP, 21q22 near SLC5A3-MRPS6-KCNE2, has been associated with coronary heart disease, cardiovascular disease, and myocardial infarction. SMIT may also be involved in the pathogeneisis of congenital cataract. SMIT also plays roles in osteogenesis, bone formation, and bone mineral density determination. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271382  Cd Length: 609  Bit Score: 592.23  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620   1 MLKTNRGTIGGFFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWTSSVMLLILGWIFVPIYIKSGVM 80
Cdd:cd11491   20 MWKSNRSTVSGYFLAGRSMTWLPVGASLFASNIGSEHFIGLAGSGAAAGFAVGAFEFNALILLQLLGWVFIPVYIRSGVY 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620  81 TMPEYLKKRFGGERLQVYLSILSLFICVVLLISADIFAGAIFIKLALGLDLYLAIFILLAMTAVYTTTGGLASVIYTDTL 160
Cdd:cd11491  100 TLPEYLSKRFGGHRIQVYLAALSLILYIFTKISVNLYSGALFIQEALGWNLYVSIILLLGLTALLTVTGGLAAVIYTDTL 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 161 QTIIMLIGSFILMGFAFNEVGGYESFTEKYVNATPSV----VEGDNLTISASCYTPRADSFHIFRDAVTGDIPWPGIIFG 236
Cdd:cd11491  180 QAFLMIIGALTLMIISMMEIGGFEGVKSRYMLASPNVtsilLTYNLSNTNSCCVHPKKDAFKLLRDPTDEDVPWPGFILG 259

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 237 MPITALWYWCTNQVIVQRCLCGKDMSHVKAACIMCAYLKLLPMFLMVMPGMISRILYTDMVACVVPSECVKHCGVDVGCT 316
Cdd:cd11491  260 QTPASIWYWCADQVIVQRVLAAKSLSHAQGATLMAGFIKLLPLFIIVIPGMISRILFPDDIACINPEHCMQVCGSRAGCS 339

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 317 NYAYPTMVLELMPQGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKMRKQASEKELLIAGRIFVLLLTVVSIVWVP 396
Cdd:cd11491  340 NIAYPRLVMKIMPSGLRGLMMAVMIAALMSDLTSIFNSASTLFTLDVYKLIRKKASSRELMIVGRIFVAVMVVISIAWIP 419

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 397 LVQVSQNGQLIHYTESISSYLGPPIAAVFVLAIFCKRVNEQGAFWGLMVGLAMGLIRMITEFAYGTGSCLAPSNCPKIIC 476
Cdd:cd11491  420 VIQEMQGGQLYLYIQEVAAYLTPPVASLYLLAIFWKRTTEQGAFYGGMAGFVLGAVRLILAFAYRAPECGQPDNRPGIIK 499

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....
gi 768025620 477 GVHYLYFSIVLFFGSMLVTLGISLLTKPIPDVHLYRLCWVLRNS 520
Cdd:cd11491  500 DIHYMYFATALFWITGLITVIVSLLTPPPTKENIRTTTFWTKKS 543
SSF pfam00474
Sodium:solute symporter family; This family includes Swiss:P33413 which is not in the Prosite ...
 12-446 2.87e-163

Sodium:solute symporter family; This family includes Swiss:P33413 which is not in the Prosite entry. Membership of this family is supported by a significant blast score.


Pssm-ID: 109527 [Multi-domain]  Cd Length: 406  Bit Score: 472.59  E-value: 2.87e-163
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620   12 FFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWTSSVMLLILGWIFVPIYIKSGVMTMPEYLKKRFG 91
Cdd:pfam00474   1 YFLAGRSMTGFVNGLSLAASYMSAASFVGLAGAGAASGLAGGLYAIGALVGVWLLLWLFAPRLRNLGAYTMPDYLRKRFG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620   92 GERLQVYLSILSLFICVVLLISADIFAGAIFIKLALGLDLYLAIFILLAMTAVYTTTGGLASVIYTDTLQTIIMLIGSFI 171
Cdd:pfam00474  81 GKRILVYLSALSLLLYFFTYMSVQIVGGARLIELALGLNYYTAVLLLGALTAIYTFFGGFLAVSWTDTIQAVLMLFGTII 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620  172 LMGFAFNEVGGYESFTEKYVNATPSVVegDNLTisascytprADSFHIFRDAVTGDIPWPGIIFGMPITalwywctnQVI 251
Cdd:pfam00474 161 LMIIVFHEVGGYSSAVEKYMTADPNGV--DLYT---------PDGLHILRDPLTGLSLWPGLVLGTTGL--------PHI 221

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620  252 VQRCLCGKDmshvkAACIMCAYLKLLPMFLMVMPGMISRILYTDMVACVVPsecvKHCGVDVGCTNYAYPTMVLELMPQG 331
Cdd:pfam00474 222 LQRCLAAKD-----AKCIRCGVLILTPMFIIVMPGMISRGLFAIALAGANP----RACGTVVGCSNIAYPTLAVKLGPPG 292

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620  332 LRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKMRKQASEKELLIAGRIFVLLLTVVSIVWVPLVQVSQNGqLIHYTE 411
Cdd:pfam00474 293 LAGIMLAVMLAAIMSTLTSQLLSSSSAFTHDLYKNIRRKASATEKELVGRSRIIVLVVISLAILLAVQPAQMG-IAFLVQ 371

                         410       420       430
                  ....*....|....*....|....*....|....*
gi 768025620  412 SISSYLGPPIAAVFVLAIFCKRVNEQGAFWGLMVG 446
Cdd:pfam00474 372 LAFAGLGSAFLPVILLAIFWKRVNEQGALWGMIIG 406
sss TIGR00813
transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the ...
 15-446 6.45e-158

transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the SSS family catalyze solute:Na+ symport. The solutes transported may be sugars, amino acids, nucleosides, inositols, vitamins, urea or anions, depending on the system. Members of the SSS family have been identified in bacteria, archaea and animals, and all functionally well characterized members catalyze solute uptake via Na+ symport. Proteins of the SSS generally share a core of 13 TMSs, but different members of the family may have different numbers of TMSs. A 13 TMS topology with a periplasmic N-terminus and a cytoplasmic C-terminus has been experimentally determined for the proline:Na+ symporter, PutP, of E. coli. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273282 [Multi-domain]  Cd Length: 407  Bit Score: 458.69  E-value: 6.45e-158
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620   15 AGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWTSSVMLLILGWIFVPIYIKSGVMTMPEYLKKRFGGeR 94
Cdd:TIGR00813   1 AGRSLGGWVVAASLFASYISASQFLGLPGAIYAYGFAIGFYELGALVLLIILGWLFVPIFINNGAYTMPEYLEKRFGK-R 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620   95 LQVYLSILSLFICVVLLISADIFAGAIFIKLALGLDLYLAIFILLAMTAVYTTTGGLASVIYTDTLQTIIMLIGSFILMG 174
Cdd:TIGR00813  80 ILRGLSVLSLILYIFLYMSVDLFSGALLIELITGLDLYLSLLLLGAITILYTVFGGLKAVVWTDTIQAVIMILGTFILPV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620  175 FAFNEVGGYESFTEKYVNATPSVvegdnltisascyTPRADSFHIFRDAVTGDIPWPGIIFGMPITALWYWcTNQVIVQR 254
Cdd:TIGR00813 160 FAFSEVGGLGTFVEKASQAAPTN-------------PSPDDLYDFFRDPSTSDLPWGAGVFGLPHVALWYW-TNQVIVQR 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620  255 CLCGKDMSHVKAACIMCAYLKLLPMFLMVMPGMISRILYTDMvacvVPSEcvkhCGVDVGCTNYAYPTMVLELMPQGLRG 334
Cdd:TIGR00813 226 CLAAKSAKHAKKGCLISGVLKLLPMFGAVLPGLIARALYTDI----DPAL----AGAVNQNSDQAYPLLVQELMPPGLAG 297

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620  335 LMLSVMLASLMSSLTSIFNSASTLFTIDLYTKMRKQASEKELLIAGRIFVLLLTVVSIVWVplVQVSQNGQLIHYTESIS 414
Cdd:TIGR00813 298 LFLAAILAAVMSTLSSQLNSASTVFTMDLYKKIIRPNASGEKKIVMRGRIAVLVAAVIAGF--VAAAQGGQVLQYVQEAF 375

                         410       420       430
                  ....*....|....*....|....*....|..
gi 768025620  415 SYLGPPIAAVFVLAIFCKRVNEQGAFWGLMVG 446
Cdd:TIGR00813 376 GGLGAPFLPVFLLGIFWKRMNAKGALAGMIAG 407
YidK COG4146
Uncharacterized membrane permease YidK, sodium:solute symporter family [General function ...
 3-453 8.19e-140

Uncharacterized membrane permease YidK, sodium:solute symporter family [General function prediction only];


Pssm-ID: 443317 [Multi-domain]  Cd Length: 444  Bit Score: 413.77  E-value: 8.19e-140
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620   3 KTNRGTIGGFFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWTSSVMLLILGWIFVPIYIKSGVMTM 82
Cdd:COG4146   28 KKKEKTSEDYFLAGRSLTWWVIGASLIATNISAEQLIGLNGSGYATGLAVAAYEWMAAIALIILALFFLPFYLKSGIYTM 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620  83 PEYLKKRFgGERLQVYLSILSLFICVVLLISADIFAGAIFIKLALGLDLYLAIFILLAMTAVYTTTGGLASVIYTDTLQT 162
Cdd:COG4146  108 PEFLEKRY-DRRTRTILSILFLVSYVFVNLPSVLYAGALALNTIFGVPLWISVIGLGIIAGIYTIFGGLKAVAYTDVIQG 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 163 IIMLIGSFILMGFAFNEVGGyesftekyvnatPSVVEG-DNLTISAscytprADSFHIFRDAVTGDIPWPGIIFGMPITA 241
Cdd:COG4146  187 IGLIIGGLLITVLGLDAVGD------------GSVLAGwSALLKVP------PEKFNMIGPADDPDLPWLGIFTGMPILN 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 242 LWYWCTNQVIVQRCLCGKDMSHVKAACIMCAYLKLLPMFLMVMPGMISRILYTDMVAcvvpsecvkhcgvdvgCTNYAYP 321
Cdd:COG4146  249 LFYWGTNQYIVQRALGAKNLKEAQKGVLFAGFLKLLIPFIVVLPGIIAFVLFPDGLD----------------NPDQAYP 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 322 TMVLELMPQGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKM-RKQASEKELLIAGRIFVLLLTVVSIVWVPLVQV 400
Cdd:COG4146  313 TLVKNLLPVGLKGLVAAALFAAIMSSLASALNSSSTLFTLDIYKKYfNPNASEKQLVKVGRIATVVLAVIAILIAPLIGN 392

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|...
gi 768025620 401 SqnGQLIHYTESISSYLGPPIAAVFVLAIFCKRVNEQGAFWGLMVGLAMGLIR 453
Cdd:COG4146  393 A--DGLFQYIQEVTGFFSPPILAVFLLGLFWKRVTAKAAKVALIAGIVLSILL 443
SLC5sbd_u2 cd11478
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ...
 12-507 5.27e-83

Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271372  Cd Length: 496  Bit Score: 269.16  E-value: 5.27e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620  12 FFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWTSSV--MLLiLGWIFVPIYIKSGVMTMPEYLKKR 89
Cdd:cd11478   30 FFLSGRSLPAWITGLAFISANLGALEIVGMSANGAQYGIATVHFYWIGAIpaMVF-LGIVMMPFYYGSKVRSVPEYLKLR 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620  90 FGGE-RLqvyLSILSLFICVVLLISADIFAGAIFIKLALGLDLYLAIFILLAMTAVYTTTGGLASVIYTDTLQTIIMLIG 168
Cdd:cd11478  109 FNKStRL---LNAVSFAVMTILMSGINLYALALVLNVLLGWPLWLSIILSAAIVLAYTTLGGLTSAIYNEVLQFFLIVAG 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 169 SFILMGFAFNEVGGYESFTEKYVNATPsvvegdnltisascytPRADSFHIFRDAVTGDIPW---PGIIFGMP-ITALWY 244
Cdd:cd11478  186 LIPLVIIGLIKVGGWDGLSEKIDANGP----------------PGWNGLSWGPQGSQSTNPMgvnLGLVFGLGfVLSFGY 249

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 245 WCTNQVIVQRCLCGKDMSHVKAACIMCAYLKLLPMFLMVMPGMISRILYtdmvacvvpSECVKHCGVDvgcTNYAYPTMV 324
Cdd:cd11478  250 WTTNFLEVQRAMAAKDLSAARRTPLIAAFPKMFIPFLVILPGLIALVLV---------PELGASGGLD---YNQALPYLM 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 325 LELMPQGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLY-TKMRKQASEKELLIAGRIFVLLLTVVSIVWVPLvqVSQN 403
Cdd:cd11478  318 AKYLPPGLLGLGITALLAAFMSGMAGNVSAFNTVFTYDIYqTYIVKDAPDKHYLKVGRIATVVGVLISIGTAYI--ASSF 395

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 404 GQLIHYTESISSYLGPPIAAVFVLAIFCKRVNEQGAFWGLMVGLAMGLIRMI-TEFAYGTGSCLAPSNcpkiicgvhyLY 482
Cdd:cd11478  396 NNIMDYLQLLFSFFNAPLFATFLLGMFWKRATPWGGFWGLLAGTASAIVLYGlYELGLIVYHSDMAPN----------FY 465

                        490       500
                 ....*....|....*....|....*
gi 768025620 483 FSIVLFFGSMLVTLGISLLTKPIPD 507
Cdd:cd11478  466 GAWWAFVVCFVVTVLVSLLTKPKPE 490
PutP COG0591
Na+/proline symporter [Amino acid transport and metabolism];
8-507 1.10e-80

Na+/proline symporter [Amino acid transport and metabolism];


Pssm-ID: 440356 [Multi-domain]  Cd Length: 476  Bit Score: 262.45  E-value: 1.10e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620   8 TIGGFFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWTSSVMLLILGWIFVPIYIKSGVMTMPEYLK 87
Cdd:COG0591   29 SLEDYFLAGRSLGWWVLALSLGATWLSAWTFLGVPGLAYAYGLSALWYALGYALGALLLALFFAPRLRRLGALTIPEFLE 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620  88 KRFGgERLQVYLSILSLFICVvLLISADIFAGAIFIKLALGLDLYLAIFILLAMTAVYTTTGGLASVIYTDTLQTIIMLI 167
Cdd:COG0591  109 KRFG-RGLRLLAAIIILLFLL-GYLAAQLVALGKLLEALFGIPYWLGILIGALIVLLYTVLGGLRAVAWTDVLQGILMLV 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 168 GSFILMGFAFNEVGGYESFTEKyvnatpsvvegdnltisascyTPRADSFHIFRDAvtgDIPWPGIIFGMPITALWYWCT 247
Cdd:COG0591  187 GLILLLIVALSALGGFGELFAA---------------------LPAPGLLSLFPGL---GFTGWLAFLGLFLAIGLGYFG 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 248 NQVIVQRCLCGKDMSHVKAACIMCAYLKLLPMFLMVMPGMISRILYTDMVAcvvpsecvkhcgvdvGCTNYAYPTMVLEL 327
Cdd:COG0591  243 QPHIVQRFLAAKSEKEARKAALIGGLLYLLFYLLAALIGLLARALFPDLPL---------------ADPDLALPLLILEL 307

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 328 MPQGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKM-RKQASEKELLIAGRIFVLLLTVVSIVWVplvqVSQNGQL 406
Cdd:COG0591  308 LPPGLAGLLLAAILAAAMSTADSQLLAASSVFTRDIYKPFiKPKASDKQLLRVSRLAVLVVGLLALLLA----LLFPSSI 383

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 407 IHYTESISSYLGPPIAAVFVLAIFCKRVNEQGAFWGLMVGLAMGLIRMITEFAygtgsclapsncpkiICGVHYLYFSIV 486
Cdd:COG0591  384 LDLVLLAWGGLGAALLPPLLLGLFWKRATKAGALAGMIAGLVVVLLWKLLGGP---------------LGPFGWLYPILP 448

                        490       500
                 ....*....|....*....|.
gi 768025620 487 LFFGSMLVTLGISLLTKPIPD 507
Cdd:COG0591  449 GLLVSLLVFVVVSLLTKPPSE 469
SLC5sbd_vSGLT cd10325
Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute ...
 3-452 7.96e-79

Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute binding domain; vSGLT transports D-galactose, D-glucose, and alpha-D-fucose, with a sugar specificity in the order of D-galactose >D-fucose >D-glucose. It transports one Na+ ion for each sugar molecule, and appears to function as a monomer. vSGLT has 13 transmembrane helices (TMs): TM-1, an inverted topology repeat: TMs1-5 and TMs6-10, and TMs 11-12 (TMs numbered to conform to the solute carrier 6 family Aquifex aeolicus LeuT). This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271360  Cd Length: 523  Bit Score: 258.77  E-value: 7.96e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620   3 KTNRGTIGGFFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWTSSVMLLILGWIFVPIYIKSGVMTM 82
Cdd:cd10325   22 KGGEKDATDYFLAGKSLPWWAIGASLIAANISAEQFIGMSGSGFAIGLAIASYEWMAAITLIIVAKFFLPIFLKNGIYTM 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620  83 PEYLKKRFGGeRLQVYLSILSLFICVVLLISADIFAGAIFIKLALGLDLYLAIFILLAMTAVYTTTGGLASVIYTDTLQT 162
Cdd:cd10325  102 PQFLEERYDG-RVRTIMAVFWLLLYVFVNLTSVLYLGALAIETITGIPLTYSIIGLALFAAAYSIYGGLKAVAWTDVIQV 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 163 IIMLIGSFILMGFAFNEVGGYEsftekyvnatpSVVEGDNLTISAScytprADSFHIFRDAVTG-----DIPWPGIIF-G 236
Cdd:cd10325  181 VFLVLGGLVTTYIALSLLGGGE-----------GVFAGFTLLAAEA-----PEHFHMILDKSNPedaykDLPGIAVLLgG 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 237 MPITALWYWCTNQVIVQRCLCGKDMSHVKAACIMCAYLKLLPMFLMVMPGMISRILYTDMVACVVPSECVKhcgvdvgct 316
Cdd:cd10325  245 LWVANLSYWGFNQYIIQRALAAKSLSEAQKGIVFAAFLKLLIPFIVVIPGIAAYVLASNLLLPAATGIEKP--------- 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 317 NYAYPTMvLELMPQGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKMR-KQASEKELLIAGRIFVLLLTVVSIVWV 395
Cdd:cd10325  316 DQAYPWL-LRNLPTGLKGLVFAALTAAIVSSLASMLNSISTIFTMDIYKKYIpKKASEKQLVNVGRLAAVIALIIAALIA 394

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 768025620 396 PLvqVSQNGQLIHYTESISSYLGPPIAAVFVLAIFCKRVNEQGAFWGLMVGLAMGLI 452
Cdd:cd10325  395 PP--LLGLDQAFQYIQEYTGFISPGILAIFLLGLFWKRATSAGALVAAILSIVLSAL 449
SLC5sbd_YidK cd10328
uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; ...
 3-499 8.80e-72

uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Uncharacterized subfamily of the solute binding domain of the solute carrier 5 (SLC5) transporter family (also called the sodium/glucose cotransporter family or solute sodium symporter family) that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily includes the uncharacterized Escherichia coli YidK protein, and belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271362  Cd Length: 472  Bit Score: 238.59  E-value: 8.80e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620   3 KTNRGTIGGFFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWTSSVMLLILGWIFVPIYIKSGVMTM 82
Cdd:cd10328   18 GDDLSSSDGYFLAGRSLTGVVIAGSLLLTNLSTEQLVGLNGQAYALGMSVMAWEVTAAIALIILALVFLPRYLKGGITTI 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620  83 PEYLKKRFGgERLQVYLSILSLFICVVLLISADIFAGAIF------IKLALGLDLYLAIFILLAMTAV----YTTTGGLA 152
Cdd:cd10328   98 PEFLEERYD-ETTRRIVSILFLLGYVVILLPIVLYSGALAlnslfdVSELLGISYFQALWLLVWLIGIigaiYAIFGGLK 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 153 SVIYTDTLQTIIMLIGSFILMGFAFNEVGGyesftekyvnatPSVVEGDNLTISAScyTPRADSFhifrDAVTGDIPWPG 232
Cdd:cd10328  177 AVAVSDTINGVGLLIGGLLIPILGLIALGD------------GSFLAGLDTLLTAH--PEKLNAI----GGADSPVPFST 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 233 IIFGMPITALWYWCTNQVIVQRCLCGKDMSHVKAACIMCAYLKLLPMFLMVMPGMISRILYTDmvacvvpsecvkhcgvD 312
Cdd:cd10328  239 LFTGMLLVNLFYWCTNQAIIQRALAAKNLKEGQKGVLLAGFFKLLVPLILVLPGIIAFHLYGD----------------G 302

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 313 VGCTNYAYPTMVLELMPQGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKM-RKQASEKELLIAGRIFVLLLTVVS 391
Cdd:cd10328  303 LENADMAYPTLVADVLPKWLSGFFAAVLFGAILSSFNSALNSAATLFSLDIYKPIiNKNATDKQLVKVGKIFGIVLALIS 382

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 392 IVWVPLVQVSQNGqLIHYTESISSYLGPPIAAVFVLAIFCKRVNEQGAfwglMVGLAMGLIrmitefAYGTGSCLAPSNc 471
Cdd:cd10328  383 MIIAPFIAYAPEG-LFNYLQQFNGFFSIPILAIVLVGFFTKRVPALAA----KIALIFGVI------LYALLQFVFLVP- 450

                        490       500
                 ....*....|....*....|....*...
gi 768025620 472 pkiicgVHYLYFSIVLFFGSMLVTLGIS 499
Cdd:cd10328  451 ------IHFLHVLAILFVICVAIMLIIG 472
SLC5sbd cd10322
Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding ...
 3-463 1.23e-70

Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; This family represents the solute-binding domain of SLC5 proteins (also called the sodium/glucose cotransporter family or solute sodium symporter family) that co-transport Na+ with sugars, amino acids, inorganic ions or vitamins. Family members include: the human glucose (SGLT1, 2, 4, 5), chiro-inositol (SGLT5), myo-inositol (SMIT), choline (CHT), iodide (NIS), multivitamin (SMVT), and monocarboxylate (SMCT) cotransporters, as well as Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) has 13 transmembrane helices (TMs): TM-1, an inverted topology repeat: TMs1-5 and TMs6-10, and TMs 11-12 (TMs numbered to conform to the solute carrier 6 family Aquifex aeolicus LeuT). One member of this family, human SGLT3, has been characterized as a glucose sensor and not a transporter. Members of this family are important in human physiology and disease.


Pssm-ID: 271357 [Multi-domain]  Cd Length: 454  Bit Score: 235.14  E-value: 1.23e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620   3 KTNRGTIGGFFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWTSSVMLLILGWIFVPIYIKSGVMTM 82
Cdd:cd10322   21 SKKVKSSEDFFLAGRSLGPWLLAGTLAATWISAGSFVGVAGLAYTYGLSAIWYILGAALGALLLALFLAPRLRRLGKTTI 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620  83 PEYLKKRFGGERLQVYLSILSlFICVVLLISADIFAGAIFIKLALGLDLYLAIFILLAMTAVYTTTGGLASVIYTDTLQT 162
Cdd:cd10322  101 PETILERYYSKGLRLLVAIII-IIALIPYLALQLIGGGYILSTLLGIPYTVAVIIAAVIVILYTVFGGMRAVAWTDVIQG 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 163 IIMLIGSFILMGFAFNEVGGYesFTEKYVNATPSvvegdnltisascytpradsfhIFRDAVTGDIPWPGIIFGMPITAL 242
Cdd:cd10322  180 IVMLIGVLVAAIFILSKVGGG--GFSALAAALPA----------------------LLLALGPGGGLGWSTILSLILLTG 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 243 WYWCTNQVIVQRCLCGKDMSHVKAACIMCAYLKLLPMFLMVMPGMISRILYTDMVAcvvpsecvkhcgvdvgcTNYAYPT 322
Cdd:cd10322  236 LGVLALPQVFQRILAAKDEKTARRAFLLAGLLLLLIGFLVALIGLAARALFPDLEN-----------------PDLALPT 298

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 323 MVLELMPQGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKM-RKQASEKELLIAGRIFVLLLTVVSIVWVPLVQvs 401
Cdd:cd10322  299 LINSLLPPGLAGLVLAGLLAAAMSTADSLLLAASTLFTRDIYKPLiNPKASDKKLLRVSRIAVVVVGVLALLLALLPP-- 376

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 768025620 402 qngQLIHYTESISSYLGPPIAAVFVLAIFCKRVNEQGAFWGLMVGLAMGLIRMITEFAYGTG 463
Cdd:cd10322  377 ---SILLLLSLAAGLLAAALFPPLLGGLFWKRATKAGAIAGIIVGLIVTLVWLLLPLASPLG 435
PRK10484 PRK10484
putative transporter; Provisional
 3-501 7.78e-68

putative transporter; Provisional


Pssm-ID: 236699 [Multi-domain]  Cd Length: 523  Bit Score: 229.77  E-value: 7.78e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620   3 KTNRGTIGGFFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWTSSVMLLILGWIFVPIYIKSGVMTM 82
Cdd:PRK10484  24 KTDTSSSDGYFLAGRSLTGPVIAGSLLLTNLSTEQLVGLNGQAYASGMSVMAWEVTAAIALIILALIFLPRYLKSGITTI 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620  83 PEYLKKRFGGERLQVyLSILSLFICVVLLISADIFAGAI-----F-IKLALGLDLYLAIFILLAMT----AVYTTTGGLA 152
Cdd:PRK10484 104 PDFLEERYDKTTRRI-VSILFLIGYVVSFLPIVLYSGALalnslFhVSELLGISYGAAIWLLVWLIgiigAIYAVFGGLK 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 153 SVIYTDTLQTIIMLIGSFILMGFAFNEVGGyesftekyvnatpsvveGDNLTISASCYTPRADSFHIFRDAvTGDIPWPG 232
Cdd:PRK10484 183 AVAVSDTINGIGLLIGGLLVPVFGLIALGD-----------------GSFMQGLEQLTTVHPEKLNSIGGA-TDPVPFPT 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 233 IIFGMPITALWYWCTNQVIVQRCLCGKDMSHVKAACIMCAYLKLLPMFLMVMPGMISRILYTDMVACvvpsecvkhcgvd 312
Cdd:PRK10484 245 LFTGLILVNLFYWCTNQSIVQRALGAKNLAEGQKGALLAAFFKLLGPLILVLPGIIAFHLYGDGLPN------------- 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 313 vgcTNYAYPTMVLELMPQGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLY-TKMRKQASEKELLIAGRIFVLLLTVVS 391
Cdd:PRK10484 312 ---ADMAYPTLVNDVLPVPLVGFFAAVLFGAILSTFNGFLNSASTLFSLDIYkPIINPNASEKQLVKVGKKFGFVLAIIS 388

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 392 IVWVPLVQVSQNGqLIHYTESISSYLGPPIAAVFVLAIFCKRVNEQGAFWGLMVG-LAMGLIRMITEFaygtgsclapsn 470
Cdd:PRK10484 389 MIVAPLIANAPQG-LYSYLQQLNGIYNVPILAIIIVGFFTKRVPALAAKVALGFGiILYIIINFVLKF------------ 455

                        490       500       510
                 ....*....|....*....|....*....|.
gi 768025620 471 cpkiicGVHYLYFSIVLFFGSMLVTLGISLL 501
Cdd:PRK10484 456 ------DIHFLYVLAILFVINVVVMLIIGKI 480
SLC5sbd_NIS-like_u2 cd11494
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative ...
 8-452 5.38e-63

uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Proteins belonging to the same subfamily as this uncharacterized subgroup include i) NIS, which transports I-, and other anions including ClO4-, SCN-, and Br-, ii) SMVT, which transports biotin, pantothenic acid and lipoate, and iii) the Na(+)/monocarboxylate cotransporters, SMCT1 and 2. SMCT1 is a high-affinity transporter while SMCT2 is a low-affinity transporter. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271385 [Multi-domain]  Cd Length: 473  Bit Score: 215.54  E-value: 5.38e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620   8 TIGGFFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWTSSVMLLILGWIFVPIYIKSGVMTMPEYLK 87
Cdd:cd11494   26 NQEDYFLGGRSMPWWPIGLSIMATQASAITFLSAPGQAYSDGMRFVQYYFGLPLAMIFLCITFVPVFYKLKVYTAYEYLE 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620  88 KRFGgerLQVYLSILSLFICVVLL-ISADIFAGAIFIKLALGLDLYLAIFILLAMTAVYTTTGGLASVIYTDTLQTIIML 166
Cdd:cd11494  106 RRFG---LKTRLLTSILFLISRGLaTGVTIYAPAIILSTILGWSLWLTILLIGGITIIYTVLGGIKAVIWTDVIQMVIIW 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 167 IGSFILMGFAFNE--VGGYESFTEKyvnatpsvVEGDNLTISAScytpradSFHIFRDAVTgdipWPGIIfGMPITALWY 244
Cdd:cd11494  183 AGLFIAFGLLLKLlpVGFVDALLVA--------GKSGRLNALDF-------SFDLSDTYTF----WSGLI-GGFFLYLSY 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 245 WCTNQVIVQRCLCGKDMSHVKAACIMCAYLKLLPMFLMVMPGMISRILYTDMVACVVPSECVkhcgVDVGCTNYAYPTMV 324
Cdd:cd11494  243 FGTDQSQVQRYLTAKSIKEARKSLLLNGFLKFPMQFFILLIGVLVFVFYQFNPFPVSFNPAE----DETKDTNYIFLRFV 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 325 LELMPQGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKM-RKQASEKELLIAGRIFVLLLTVVSIvwVPLVQVSQN 403
Cdd:cd11494  319 LNYLPPGVIGLLIAAIFAAAMSSIDSALNSLATVTVIDIYRRFfKKDASDEHYLKVSRLLTVFWGLLAI--VFALFAGLA 396

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*....
gi 768025620 404 GQLIHYTESISSYLGPPIAAVFVLAIFCKRVNEQGAFWGLMVGLAMGLI 452
Cdd:cd11494  397 GSLIEAVNKLGSLFYGPILGVFLLAFFTKKANGKGVFAGAILGVIVVIV 445
SLC5sbd_u1 cd11477
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ...
 12-512 3.07e-53

Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271371  Cd Length: 493  Bit Score: 189.71  E-value: 3.07e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620  12 FFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWTSSVMLLILGWIFVPIYIKSGVMT----MPEYLK 87
Cdd:cd11477   31 FFLGGRKLPWWLAGISMAATTFSADTFVAVAGIAYTYGIAGNWIWWLWAVAGLIGAFVFARRWRRLRVLTdgefPEERYG 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620  88 KRFGGeRLQVYLSILSLFIcVVLLISADIFAGAIFI-KLALGLDLYLAIFILLAMTAVYTTTGGLASVIYTDTLQTIIML 166
Cdd:cd11477  111 GRYGA-PLRQFYAVYFALL-SNVDILAWVFLAAIKVsAVFGPWDPWLTILILGLITLIYTVIGGLWAVVVTDVVQFVIAM 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 167 IGSFILMGFAFNEVGGYESFTEKyvnatpsvVEGDNLTISASCYTPRADSFHIFRdavtgdIPWPGIIFGMPITALWYwc 246
Cdd:cd11477  189 AASIAVAVLALNAVGGPGGLFAQ--------LPEGHLDLFGSGLGASGFYITFFF------ILFFGWYPLSYSGGGWY-- 252

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 247 tnqvIVQRCLCGKDMSHVKAACIMCAYLKLLPMFLMVMPGMISRILYTDMVACVVPSEcvkhcgvdvgctnYAYPTMVLE 326
Cdd:cd11477  253 ----LAQRYLSAKSEKAAKAAAWLFAALYLVRPWPWMLPALAALVLYPDLDDPEADFE-------------LAYPMMIKE 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 327 LMPQGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTK-MRKQASEKELLIAGRIFVLLLTVVSIVWVplVQVSQNGQ 405
Cdd:cd11477  316 YLPAGLLGLVLAGLLAATMSTVSTHLNWGAAYLVNDIYKRfIKPNASEKHLLKVGRLATVLFGLLSIVVA--LASDSIGG 393

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 406 LIHYTESISSYLGPPIAAVFVLAifckRVNEQGAFWGLMVGLAMGLIrmitefaygtgsclAPSNCPKIICGVHYLYFSI 485
Cdd:cd11477  394 AFWIVLALGAGLGGPLILPWLWW----RFNAWTEIWAMIASIIVGLV--------------VSVLLKVFGLPEDFLFSFL 455

                        490       500
                 ....*....|....*....|....*..
gi 768025620 486 VLFFGSMLVTLGISLLTKPIPDVHLYR 512
Cdd:cd11477  456 VPVLLSLVVWLAVTLLTPPTDEETLVA 482
SLC5sbd_NIS-like_u3 cd11495
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative ...
 12-448 1.68e-42

uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Proteins belonging to the same subfamily as this uncharacterized subgroup include i) NIS, which transports I-, and other anions including ClO4-, SCN-, and Br-, ii) SMVT, which transports biotin, pantothenic acid and lipoate, and iii) the Na(+)/monocarboxylate cotransporters SMCT1 and 2. SMCT1 is a high-affinity transporter while SMCT2 is a low-affinity transporter. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271386 [Multi-domain]  Cd Length: 473  Bit Score: 159.24  E-value: 1.68e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620  12 FFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWTSSVMLLILGWIFVPIYIKSGVMTMPEYLKKRFg 91
Cdd:cd11495   33 YFKGGGRIPWWAAGLSIFATTLSSITFLAIPGKAYATDWNYFVGSLSIIIAAPLAAYFFVPFFRRLNVTSAYEYLEKRF- 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620  92 GERLQVYLSIL-SLF----ICVVLLISadifagAIFIKLALGLDLYLAIFILLAMTAVYTTTGGLASVIYTDTLQTIIML 166
Cdd:cd11495  112 GPWARVYGSLLfILFqlgrMGIVLYLP------ALALSAVTGINPYIIIILMGVLCIIYTVLGGIEAVIWTDVIQGVVLL 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 167 IGSFILMGFAFNEVGGyeSFTEKYVNAtpsvVEGDNLTISASCYTPRADSFhifrdavtgdipwPGIIFGMPITALWYWC 246
Cdd:cd11495  186 GGALLCLIILLFSIPG--GFGEVFDIA----IANGKFSLGDFSFSLTESTI-------------WVIFIGGIFNNLQSYT 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 247 TNQVIVQRCLCGKDMSHVKAACIMCAYLKLLPMFLMVMPGMISRILYTDMVAcvVPSECVKhcgvdvgcTNYAYPTMVLE 326
Cdd:cd11495  247 SDQDVVQRYLTTKSIKEAKKSLWTNALLALPVALLFFGIGTALYVFYQQHPE--LLPAGIN--------GDAVFPYFIVT 316

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 327 LMPQGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKMRKQASEKELLIAGRIFVLLLTVVSIVWVPLVQVSQNGQL 406
Cdd:cd11495  317 QLPVGVAGLIIAAIFAAAMSTISSSLNSVATCITTDFYKRLSPDPSDKQYLKVARLITLLVGLLGTLVALYLANAGVKSL 396

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|..
gi 768025620 407 IHYTESISSYLGPPIAAVFVLAIFCKRVNEQGAFWGLMVGLA 448
Cdd:cd11495  397 LDAFNTLTGLFGGGLAGLFLLGIFTKRANAKGALVGIIVSII 438
SLC5sbd_NIS-like cd10326
Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute ...
 11-461 5.92e-39

Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; NIS (product of the SLC5A5 gene) transports I-, and other anions including ClO4-, SCN-, and Br-. SMVT (product of the SLC5A6 gene) transports biotin, pantothenic acid and lipoate. This subfamily also includes SMCT1 and 2. SMCT1(the product of the SLC5A8 gene) is a high-affinity transporter of various monocarboxylates including lactate and pyruvate, short-chain fatty acids, ketone bodies, nicotinate and its structural analogs, pyroglutamate, benzoate and its derivatives, and iodide. SMCT2 (product of the SLC5A12 gene) is a low-affinity transporter for short-chain fatty acids, lactate, pyruvate, and nicotinate. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271361 [Multi-domain]  Cd Length: 472  Bit Score: 149.25  E-value: 5.92e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620  11 GFFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWTSSVMLLILGWIFVPIYIKSGVMTMPEYLKKRF 90
Cdd:cd10326   28 DFFLGNRQSPWYLVAFSMIGTSLSGVTFVSVPGEVGGSGFTYLQMVLGFLLGYLIIAFVLLPLYYRLNLTSIYEYLEDRF 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620  91 GGE--RLQVYLSILSLFICVVLLISADIFAGAIFIKLALGLDLYLAIFILLAMTAVYTTTGGLASVIYTDTLQTIIMLIG 168
Cdd:cd10326  108 GVSsrKTGAVFFLLSRILGAGIRLYLVALVLQQFLFDSLGIPFWLTVLITGLLIWLYTFRGGIKTVVWTDTLQTVFLLVG 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 169 SFILMGFAFNEVGGyeSFTEkyvnatpsvvegdnlTISASCYTPRADSFHiFRDAVTGDIPWPGIIFGMpITALWYWCTN 248
Cdd:cd10326  188 LVLTIIIISNSLGL--GFGE---------------AISAAGESGYSRIFN-FDDDNSRRTFWKQFLGGI-FITIAMTGLD 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 249 QVIVQRCLCGKDMSHVKAACIMCAYLKLLPMFLMVMPGMisrILYTDMVACVVPsecvkhcgVDVGCTNYAYPTMVLELM 328
Cdd:cd10326  249 QDMMQRNLSCKNLKDAQKNMLTFGVILVPVNLLFLLLGV---LLYTYAQKNGIA--------LPAKDSDQLFPYFALNGL 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 329 PQGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKMRK---QASEKELLIAGRIFVLLLTVVSIVWvplvqVSQNGQ 405
Cdd:cd10326  318 PPGVSGLFVAGIIAAAMSSADSALTALTTSFCVDILNRFKRkseKKSERKYVHIAFSLTFVLGILVFGS-----ASNSGS 392

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 768025620 406 LIHYTESISSYLGPPIAAVFVLAIFCKRVNEQ--GAFWGLMVGLAMGLIRMITEFAYG 461
Cdd:cd10326  393 LIDAIFKVAGYTYGPLLGLFAFGLFTKRAVKDkwVPLVGLLAPVLSYLLVSNSEGFFG 450
SLC5sbd_PutP cd11475
Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Escherichia coli ...
 8-452 6.11e-37

Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Escherichia coli PutP catalyzes the Na+-coupled uptake of proline with a stoichiometry of 1:1. The putP gene is part of the put operon; this operon in addition encodes a proline dehydrogenase, allowing the use of proline as a source of nitrogen and/or carbon. This subfamily also includes the Bacillus subtilis Na+/proline cotransporter (OpuE) which has an osmoprotective instead of catabolic role. Expression of the opuE gene is under osmotic control and different sigma factors contribute to its regulation; it is also a putative CcpA-activated gene. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271369  Cd Length: 464  Bit Score: 143.42  E-value: 6.11e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620   8 TIGGFFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVtfeWTSSVMLL--ILGWIFVPIYI-----KSGVM 80
Cdd:cd11475   24 TLEDYFLGGRSLGPWVTALSAGASDMSGWLLLGLPGAAYASGLSAI---WIAIGLILgaYLNWLFVAKRLrryteKNDSI 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620  81 TMPEYLKKRFGGER--LQVyLSILSLFICVVLLISADIFAGAIFIKLALGLDLYLAIFILLAMTAVYTTTGGLASVIYTD 158
Cdd:cd11475  101 TLPDYLENRFRDKSklLRI-LSALIILIFFTIYAAAQLVAGGKLFESLFGIDYSTGLLIGAVVVVAYTFLGGFLAVSWTD 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 159 TLQTIIMLIGSFILMGFAFNEVGGYESFTEKYVNATPsvvegdnltisascytpraDSFHIFRDAvTGDIPWPGII---- 234
Cdd:cd11475  180 FFQGLLMLLALVLVPIVALAALGGLSGLVAALAAIDP-------------------GLLSPFGGD-LGAGGLLAIIslla 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 235 -----FGMPitalwywctnQVIVqRCLCGKDMSHVKAACIMCAYLKLLPMFLMVMPGMISRILYTDMVAcvVPSEcvkhc 309
Cdd:cd11475  240 wglgyFGQP----------HILV-RFMAIRSPKEIKKARRIAMVWMILFLLGAVLVGLLGRALFPDGLL--GDPE----- 301

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 310 gvdvgctnYAYPTMVLELMPQGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKM-RKQASEKELLIAGRIFVLLLT 388
Cdd:cd11475  302 --------TVFPVLAQELFPPWLAGILLAAILAAIMSTADSQLLVCSSALTEDLYKAFlRKEASDKELVWVSRLAVLVIA 373

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 768025620 389 VVSIVWvPLVQVSQNGQLIHYTES-ISSYLGPPIaavfVLAIFCKRVNEQGAFWGLMVGLAMGLI 452
Cdd:cd11475  374 LIALLI-ALNPPSSVFSLVSFAWAgLGAAFGPLL----LLSLYWKRTTRQGALAGMIAGAVTVVV 433
SLC5sbd_NIS-like_u1 cd11493
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative ...
 11-461 4.49e-35

uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Proteins belonging to the same subfamily as this uncharacterized subgroup include i) NIS, which transports I-, and other anions including ClO4-, SCN-, and Br-, ii) SMVT, which transports biotin, pantothenic acid and lipoate, and iii) the Na(+)/monocarboxylate cotransporters SMCT1 and 2. SMCT1 is a high-affinity transporter while SMCT2 is a low-affinity transporter. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271384 [Multi-domain]  Cd Length: 479  Bit Score: 138.50  E-value: 4.49e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620  11 GFFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWTSSVMLLILGWIFVPIYIKSGVMTMPEYLKKRF 90
Cdd:cd11493   28 DYFLGGRSMPWWAVCLSVVATETSTLTFLSIPGLAYGGDLTFLQLALGYILGRIIVAFVLLPRYFRGEVVSAYELLGQRF 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620  91 GGeRLQVYLSILslFICVVLLIS-ADIFAGAIFIKLALGLDLY-----LAIFILLAMTAVYTTTGGLASVIYTDTLQTII 164
Cdd:cd11493  108 GG-GMQKTASVT--FLVTRLLADgVRLFAAAIPVSMILGADGValsyiASILIISVVTLLYTYFGGIRAVVWTDVIQLVV 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 165 MLIGSFILMGFAFNEVGGYESFTEKYVNATPSVVEGDNLTISASCYTPRAdsfhifrdAVTGdipwpGIIFGMPITAlwy 244
Cdd:cd11493  185 YIGGAVAALAYLLGALPADWLQIAAAAGKFHLFDLSDLILGLTSPYTFWA--------AIIG-----GALLSMASHG--- 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 245 wcTNQVIVQRCLCGKDMSHVKAACIMCAYLKLLPMFLMVMPGMISRILYTDMVACvvpsecvkhcGVDVGCTNYAYPTMV 324
Cdd:cd11493  249 --TDQLMVQRLLACRNLRDAQKALIGSGVVVFPQFALFLLIGLLLYVYYGGASLA----------ALGLGSPDEVFPYFI 316

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 325 LELMPQGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYT-KMRKQASEKELLIAGRIFVLLLTVVSIVwVPLVQVSQN 403
Cdd:cd11493  317 VHELPAGLRGLLIAGILAAAMSTLSSALNSLASSTVQDLYQpWKRRRLSDEKLLRASRLLTLVWAVVLVG-IALLFQYTD 395

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 768025620 404 GQLIHYTESISSYLGPPIAAVFVLAIFCKRVNEQGAFWGLMVGL-AMGLIRMITEFAYG 461
Cdd:cd11493  396 QPVVELGLSIASFTYGGLLGVFLLGLLTRRASQRDAIAAFIVGFlVMLLLIFGVKFLGL 454
PanF COG4145
Na+/panthothenate symporter [Coenzyme transport and metabolism];
7-504 4.90e-35

Na+/panthothenate symporter [Coenzyme transport and metabolism];


Pssm-ID: 443316  Cd Length: 484  Bit Score: 138.43  E-value: 4.90e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620   7 GTIGGFFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATV----TFEWTSSVMLLILGWIFVPIYIKSGVMTM 82
Cdd:COG4145   32 SFLEEYFLGSRSMGGFVLAMTLAATYTSASSFIGGPGAAYKYGLGWVllamIQVPTAFLTLGVLGKKFAILGRKYNAVTL 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620  83 PEYLKKRFGGErlqvYLSILSLFICVVLLIS---ADIFAGAIFIKLALGLDLYLAIFILLAMTAVYTTTGGLASVIYTDT 159
Cdd:COG4145  112 ADWLRARYQSK----ALVLLAALLLLLFFIAfmvAQFVGGARLLETVTGISYTTGLLIFGVTVVLYTTIGGFRAVVLTDA 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 160 LQTIIMLIGSFILMGFAFNEVGGYESFTEKYVNATPSVVEGDNltisascytprADSFhifrdavtgdIPWPGIIFGMPI 239
Cdd:COG4145  188 IQGIIMLVGTVLLLIGVISAGGGIENIMSTLAAIDPNLVSPTG-----------PDGF----------LPRPFVISFWIL 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 240 TALWYWCTNQVIVqRCLCGKDMSHVKAACIMCAYLKLLPMFLMVMPGMISRILYTDMVAcvvpsecvkhcgvdvgcTNYA 319
Cdd:COG4145  247 VGFGVIGLPHTAV-RCMAYKDSKSLHRAMIIGTIVVGLLMFGMHLIGVLGRAVLPDLTV-----------------PDQV 308

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 320 YPTMVLELMPQGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYT---KMRKQASEKELLIAGRIFVLLLTVVSIV--W 394
Cdd:COG4145  309 IPTLMVKVLPPFLAGIFLAGPLAAIMSTVDSLLLQASSTIVKDLYLnyiNPKASENEKKLKRLSKLVTLVLGLIVFLlaL 388

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 395 VP---LVQVSQNGqlihYTESISSYLGPpiaavFVLAIFCKRVNEQGAFWGLMVGLAMGLIRMITEFAygtgsclapsnc 471
Cdd:COG4145  389 NPpdlIIWLNLFA----FGGLEAAFFWP-----LVLGLYWKRANATGAIASMLVGVASYFLLYYGNPK------------ 447

                        490       500       510
                 ....*....|....*....|....*....|...
gi 768025620 472 pkiICGVHYLYFSIVLffgSMLVTLGISLLTKP 504
Cdd:COG4145  448 ---IFGFHAIVPSLLI---SLIAFLIGSLLGKP 474
SLC5sbd_CHT cd11474
Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding ...
 12-499 2.98e-34

Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Na+/choline co-transport by CHT is Cl- dependent. Human CHT (also called CHT1) is encoded by the SLC5A7 gene, and is expressed in the central nervous system. hCHT1-mediated choline uptake may be the rate-limiting step in acetylcholine synthesis, and essential for cholinergic transmission. Changes in this choline uptake in cortical neurons may contribute to Alzheimer's dementia. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271368 [Multi-domain]  Cd Length: 464  Bit Score: 135.73  E-value: 2.98e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620  12 FFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFE-WTSSVMLLILGWIFVPIYIKSGVMTMPEYLKKRF 90
Cdd:cd11474   28 FLLAGRSLPLPVGVFTLFATWFGGETILGAAETFYEEGLGGVAQDpFGYALCLILGGLFFAKPMRRMGLLTLGDFFRQRY 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620  91 GgERLQVYLSILSLfICVVLLISADIFAGAIFIKLALGLDLYLAIFILLAMTAVYTTTGGLASVIYTDTLQTIIMLIGSF 170
Cdd:cd11474  108 G-RRVEVLLSIPAV-LSYLGWVAAQLVALGLVLSVILGLPVETGILISAAIVLAYTLFGGMWSVAYTDVVQLIVIFVGLL 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 171 ILMGFAFNEVGGYESFTEKYVNATPSVVEGDnltisascytPRADSFHIFRDAVT---GDIPWpgiifgmpitalwywct 247
Cdd:cd11474  186 VLVPFVLTNPGGVDIASAAAAGKLRFFPWLG----------TKSDWLIWIDAWLTlglGSIPQ----------------- 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 248 nQVIVQRCLCGKDMSHVKAACI----MCAYLKLLPMFLmvmpGMISRILYTDMVACVVPSEcvkhcgvdvgcTNYAYPTM 323
Cdd:cd11474  239 -QDVFQRVLSAKSEKTAQRLSLlagvGYLLFAIPPLLI----GLAAASIDPSLTQYGLEED-----------AQLILPLL 302

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 324 VLELMPQGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLY-TKMRKQASEKELLIAGRIFVLLLTVVSIVwvplvqVSQ 402
Cdd:cd11474  303 LQYLTPLWVQVLFLGALLSAVMSTADSALLAPSSVFSENIYkPPFRPKASDRELLWVMRISVVVFGAIATL------MAL 376

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 403 NGQLIHYTESISSYLGPPIAAV-FVLAIFCKRVNEQGAFWGLMVGLamgLIRMITEFAYGTgsclAPSNCPKIICGvhyL 481
Cdd:cd11474  377 TVESIYGLVELASDLVLVGLFVpLLAGLYWKRANTYGALAAIIVGL---VLRLLGGELLLG----LPADIPPQLQG---F 446

                        490
                 ....*....|....*...
gi 768025620 482 YFSIVLFFGSMLVTLGIS 499
Cdd:cd11474  447 PFSTLAMVIGSLLPLAVS 464
SLC5sbd_NIS-SMVT cd11492
Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute ...
 12-463 6.40e-31

Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; NIS (encoded by the SLC5A5 gene) transports I-, and other anions including ClO4-, SCN-, and Br-. SMVT (encoded by the SLC5A6 gene) transports biotin, pantothenic acid and lipoate. This subfamily also includes SMCT1 and -2. SMCT1(encoded by the SLC5A8 gene) is a high-affinity transporter of various monocarboxylates including lactate and pyruvate, short-chain fatty acids, ketone bodies, nicotinate and its structural analogs, pyroglutamate, benzoate and its derivatives, and iodide. SMCT2 (encoded by the SLC5A12 gene) is a low-affinity transporter for short-chain fatty acids, lactate, pyruvate, and nicotinate. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271383 [Multi-domain]  Cd Length: 522  Bit Score: 126.83  E-value: 6.40e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620  12 FFLAGRDMAWWPMGASLFASNIGSnhyVGLAGTGAAS---GVATVTFEWTSSVMLLILGWIFVPIYIKSGVMTMPEYLKK 88
Cdd:cd11492   33 YLLGGRNMSVFPVALSLIASFISG---ITLLGTPAEIyyyGTQYWLIVIAYVLVGPITAYIFLPVFYNLQLTSVYEYLEL 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620  89 RFGgERLQVYLSILslFI-CVVLLISADIFAGAIFIKLALGLDLYLAIFILLAMTAVYTTTGGLASVIYTDTLQTIIMLI 167
Cdd:cd11492  110 RFN-RRVRLLASFL--FIlQMLLYLPIVIYAPALALSQVTGINLHIIILVVGIVCIFYTTLGGLKAVVWTDVFQVVVMFG 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 168 GSFILMGFAFNEVGGYESFTEKyvnatpsVVEGDNLTISAscYTPRADSFHIFrdavtgdipWpGIIFGMPITALWYWCT 247
Cdd:cd11492  187 GVLAVIILGTIDVGGFSEVWEI-------AEEGGRLEFFN--FDPDPTVRHTF---------W-SLVIGGTFTWLSLYGV 247

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 248 NQVIVQRCLCGKDMSHVKAACIMCAYLKLLPMFLMVMPGMisrILYTDMVACvvpsecvkhcgvDVGCTNYA------YP 321
Cdd:cd11492  248 NQTQVQRYLSLPSLKSAKKALWLNIVGLILILSLCCFTGL---VIYAKYHDC------------DPLTAGLIkkpdqlLP 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 322 TMVLELMPQ--GLRGLMLS-VMLASLmSSLTSIFNSASTLFTIDLY-TKMRKQASEKELLIAGRIFVLLLTVVSIVWVPL 397
Cdd:cd11492  313 YFVMDVLGHlpGLPGLFVAgIFSAAL-STLSSGLNSLAAVILEDFIkPFFKKKLSERQATNIMKLLVVVFGLLCIGLAFL 391

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 768025620 398 VQVSqnGQLIHYTESISSYLGPPIAAVFVLAIFCKRVNEQGAFWGLMVGLA-MGLIRMITEFAYGTG 463
Cdd:cd11492  392 VEKL--GGVLQLSLSIFGITGGPLLGIFTLGMFFPWANSKGALVGLLVGLIfMLWIGIGGQIAIAPG 456
SLC5sbd_SMCT2 cd11520
Na(+)/monocarboxylate cotransporter SMCT2 and related proteins; solute-binding domain; SMCT2 ...
 5-502 1.66e-23

Na(+)/monocarboxylate cotransporter SMCT2 and related proteins; solute-binding domain; SMCT2 is a low-affinity transporter for short-chain fatty acids, lactate, pyruvate, and nicotinate. Human SMCT2 (hSMCT2) is encoded by the SLC5A12 gene. SMCT2 is expressed in the kidney, small intestine, skeletal muscle, and retina. In the kidney, it is expressed in the apical membrane of the proximal convoluted tubule, along the entire length of the tubule (in contrast to the high-affinity monocarboxylate transporter SMCT1, belonging to a different family, which is limited to the S3 segment of the tubule). SMCT2 may initiate lactate absorption in the early parts of the tubule. In the retina, SMCT1 and SMCT2 may play a differential role in monocarboxylate transport in a cell type-specific manner, SMCT2 is expressed exclusively in Muller cells. Nicotine transport by hSMCT2 is inhibited by several non-steroidal anti-inflammatory drugs. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 212089 [Multi-domain]  Cd Length: 529  Bit Score: 104.55  E-value: 1.66e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620   5 NRGTIGGFFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWTSSVMLLILGWIFVPIYIKSGVMTMPE 84
Cdd:cd11520   32 KKATSKEFLVGGRQMSCGPVALSLTASFMSAVTVLGTPAEVYRFGASFVLFFIAYTFVIIFTSELFLPVFYRSGITSTYE 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620  85 YLKKRFggERLQVYLSILSLFICVVLLISADIFAGAIFIKLALGLDLYLAIFILLAMTAVYTTTGGLASVIYTDTLQTII 164
Cdd:cd11520  112 YLELRF--NKPVRYAATLIYIVQTILYTGVVVYAPALALNQVTGFDLWGSVFATGIVCTFYCTLGGLKAVVWTDAFQMVV 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 165 MLIGSFILMGFAFNEVGGYESFTEKYVNatpsvveGDNLTISASCYTP-RADSFHIFrdAVTGDIPWPGIifgmpitalw 243
Cdd:cd11520  190 MVVGFLTVLIQGSIHNGGFTNVWETAYN-------GSRLNIFDFDVDPlRRHTFWTI--TVGGTFTWLGI---------- 250

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 244 yWCTNQVIVQRCLCGKDMSHVKAACimcaYLKLLPMFLMVMPGMIS-RILYTDMVACVVPSECVkhcgvdVGCTNYAYPT 322
Cdd:cd11520  251 -YGVNQSTIQRCISCKTEKHAKLAL----YLNLLGLWIILVCAVFSgLIMYSHYKDCDPWTSGF------ISAPDQLMPY 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 323 MVLEL---MPqGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKMRKQASEKELLIAGRIFVLLLTVVSIVWVplVQ 399
Cdd:cd11520  320 FVMEIfstMP-GLPGLFVACAFSGTLSTVAASINALATVTFEDFVKSCFPHLSEKLSTWISKGLCILFGVMCTSMA--VA 396

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 400 VSQNGQLIHYTESISSYLGPPIAAVFVLAIFCKRVNEQGAFWGLMVGLAMGLIRMITEFAY------------GTGSC-- 465
Cdd:cd11520  397 ASLMGGVVQAALSIHGMCGGPMLGLFTLGIVFPFVNWKGALGGLLTGITLSFWVGIGAFIYpapssktlplelSTAGCil 476

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|..
gi 768025620 466 -----LAPSNCPKIIC----------GVHYLYFSIVLFFGSMLVTLGISLLT 502
Cdd:cd11520  477 anstaTPTPATPILTSdrplladtwySLSYLYYSAVGCLGCIAAGLLISFLT 528
SLC5sbd_u3 cd11479
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ...
 12-506 2.02e-23

Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271373  Cd Length: 454  Bit Score: 103.45  E-value: 2.02e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620  12 FFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWTSSVMLLILGWIFVPIYIKSGVMTMPEYLKKRFG 91
Cdd:cd11479   30 YLVAGRRLGPGLYLGTMAAVVLGGASTIGGVGLGYQYGISGMWLVVAIGLGILALSLLLAKRIARLKVYTVSEVLELRYG 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620  92 GeRLQVYLSILSLFICVVLLISADIFAGAIFIKLaLGLDLYLAIFILLAMTAVYTTTGGLASVIYTDTLQTIIMLIGSF- 170
Cdd:cd11479  110 P-SARVISALVMLAYTLMVAVTSTIAIGTVFSVL-FGLPRTLSILVGGGIVVLYSVLGGMWSITLTDIIQFVIKTIGIFl 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 171 ILMGFAFNEVGGYESFTEKyvnatpsvvegdnltISASCYTPradsfhifrdavtGDIPWPGII-------FGMPItalw 243
Cdd:cd11479  188 LLLPLALSKAGGLSGLQEK---------------LPASYFDL-------------TSIGWDTIVtyfllyfFGILI---- 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 244 ywctNQVIVQRCLCGKDMSHVKAACIMCAYLKLLPMFLMVMPGMISRILYTDmvacvvpsecvkhcgvdVGCTNYAYPTM 323
Cdd:cd11479  236 ----GQDIWQRVFTARSEKVARWGGVAAGLYCVLYGVAGALIGMAAAVLLPD-----------------LANPQNAFATM 294

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 324 VLELMPQGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKM-RKQASEKELLIAGRIFVLLLTVVSIVWVPLVQVSQ 402
Cdd:cd11479  295 AQEVLPVGLRGLVLAAALAAMMSTASGALLASSTVLTNDVLPRLrRKNESERSEVRLSRLFTLLLGVVVIVIAVLVNDVV 374

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 403 NGQLIHYTESISSYLGPpiaavFVLAIFCKRVNEQGAFWGLMVGLAMGLIRMITefaYGTgsclaPSNCPkiicgvhyLY 482
Cdd:cd11479  375 AALTIAYAILVGGLLVP-----ILGGLFWKRATGAGALASMVAGSVVVLAGMAV---DGL-----LANTP--------IY 433

                        490       500
                 ....*....|....*....|....
gi 768025620 483 FSIVLffgSMLVTLGISLLTKPIP 506
Cdd:cd11479  434 YGLAV---SLVAFVAVSLLTRPTP 454
SLC5sbd_DUR3 cd11476
Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain; Dur3 is ...
 26-452 2.99e-23

Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain; Dur3 is the yeast plasma membrane urea transporter. Saccharomyces cerevisiae DUR3 also transports polyamine. The polyamine uptake of S. cerevisiae DUR3 is activated upon its phosphorylation by polyamine transport protein kinase 2 (PTK2). S. cerevisiae DUR3 also appears to play a role in regulating the cellular boron concentration. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271370  Cd Length: 493  Bit Score: 103.44  E-value: 2.99e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620  26 ASLFASNIGSNHYVGLAGTGAASGVATVT-FEWTSSVMLLIlgwiFVPIYIKS-----GVMTMPEYLKKRFGGERLQVYL 99
Cdd:cd11476   49 AAIVSSWTWAATLLQSATVAYQYGVSGPFwYASGATLQILL----FAPLAIRIkrlapNAHTLLEIVRARYGTAAHLVFL 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 100 sILSLFiCVVLLISADIFAGAIFIKLALGLDLYLAIFILLAMTAVYTTTGGLASVIYTDTLQTIIMLIGSFILMGFAF-- 177
Cdd:cd11476  125 -VFALF-TNVIVLAMLLLGGSAVVNALTGMPIVAASFLIPLGVLLYTLFGGLRATFLTDYIHTVIILIILLVFAFAVYts 202

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 178 NEVGGYESFTEKYVNATPSVVEGDNltisascytprADSFHIFRDavtgdipWPGIIFGMP--ITALWYWCTNQVIVQRC 255
Cdd:cd11476  203 SDIGSPSKVYDLLQEAAPDLPVEGN-----------QGSYLTFKS-------KAGLIFGIIniVGNFGTVFLDQGYWQRA 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 256 LCGKDMSHVKAACI--MCAYlkLLPMFLMVMPGMISRILYTDmvacvvpsecVKHCGVDVGctnYAYPTMVLELMPQGLR 333
Cdd:cd11476  265 IAARPSAAVKGYFLggLAWF--AIPFLLATTLGLAALALGLN----------PTFEEVSAG---LVLPYVAAALLGKGGA 329

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 334 GLMLSVMLASLMSSLTSIFNSASTLFTIDLY-TKMRKQASEKELLIAGRIFVLLLTVVSIVW-VPLVQVSQN-GQLIHYT 410
Cdd:cd11476  330 AAVLVLLFMAVTSTASAELIAVSSIVTYDIYrTYINPNATGKQLLRVSRIAVIGFGLFMGGLaVGLNYIGISlGWLLLFM 409

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....
gi 768025620 411 ESISSylgppiAAVF--VLAIFCKRVNEQGAFWGLMVGLAMGLI 452
Cdd:cd11476  410 GILIG------SAVFpvALGLYWRRQTGTAAVVSPIAGLVAGLA 447
SLC5sbd_SMVT cd11504
Na(+)/multivitamin cotransporter SMVT and related proteins; solute-binding domain; This ...
 6-506 2.71e-22

Na(+)/multivitamin cotransporter SMVT and related proteins; solute-binding domain; This multivitamin transporter SMVT (product of the SLC5A6 gene) transports biotin, pantothenic acid and lipoate, and is essential for mediating biotin uptake into mammalian cells. SMVT is expressed in the placenta, intestine, heart, brain, lung, liver, kidney and pancreas. Biotin may regulate its own cellular uptake through participation in holocarboxylase synthetase-dependent chromatin remodeling events at SMVT promoter loci. The cis regulatory elements, Kruppel-like factor 4 and activator protein-2, regulate the activity of the human SMVT promoter in the intestine. Glycosylation of the hSMVT is important for its transport function. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271394 [Multi-domain]  Cd Length: 527  Bit Score: 100.72  E-value: 2.71e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620   6 RGTIGGFFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWTSSVMLLILGWIFVPIYIKSGVMTMPEY 85
Cdd:cd11504   30 QKTTREFLMADRKMGCLPVALSLLATFQSAVAILGGPSESYTFGTQYWFLGCSYFLGLLIPAHVFIPVFYRLELTSAYEY 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620  86 LKKRFggERLQVYLSILSLFICVVLLISADIFAGAIFIKLALGLDLYLAIFILLAMTAVYTTTGGLASVIYTDTLQTIIM 165
Cdd:cd11504  110 LELRF--NKTVRICGTVTFIFQMVIYMGVVLYAPALALNAVTGFNLWISVLAMGVVCTFYTALGGLKAVIWTDVFQTVVM 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 166 LIGSFILMGFAFNEVGGYESFTEKYVNATpsvvegdnltisascytpRADSFHIFRDAVTGDIPWPgIIFGMPITALWYW 245
Cdd:cd11504  188 FAGQLAVIIVGSIEAGGIARVWRVAAESD------------------RIDGFNLSPDPTIRHTFWT-LVVGGVFNMLALY 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 246 CTNQVIVQRCLCGKDMSHVKAACIMCAYLKLLPMFLMVMPGMISRILYtdmvacvvpSECVKHCGVDVGCTNYAYPTMVL 325
Cdd:cd11504  249 GVNQAQVQRYLSSRTEKQAKRSCYLVFPGQQLSLCIGCLCGLVMFARY---------HECDPLKNGIVARSDQLVPYFVM 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 326 ELMPQ--GLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKMRKQASEKELLIAGRIFVLLLTVVSIVWVPLvqVSQN 403
Cdd:cd11504  320 DVLDGlpGLPGLFIACLFSGALSTISSAFNSLATVTMEDLIVPKFPDMTEERATLLSKGLAVGYGLLCLLMAYL--ASTM 397

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 404 GQLIHYTESISSYLGPPIAAVFVLAIFCKRVNEQGAFWGLMVGLAMGlirmiteFAYGTGSCLAPSNCPKIICGVHYLYF 483
Cdd:cd11504  398 GQVLQAANSIFGMIGGPLLGLFCLGMFFPCANSAGAVVGLLAGLFMA-------FWIGIGSKVFPPYSPTKSTPINDCIF 470

                        490       500
                 ....*....|....*....|...
gi 768025620 484 SIVLFFGSMLVTLGISLLTKPIP 506
Cdd:cd11504  471 PNVTMANATTPTTPFATPTDEPP 493
SLC5sbd_SMCT cd11505
Na(+)/monocarboxylate cotransporters SMCT1 and 2 and related proteins; solute-binding domain; ...
 12-460 5.41e-22

Na(+)/monocarboxylate cotransporters SMCT1 and 2 and related proteins; solute-binding domain; SMCT1 is a high-affinity transporter of various monocarboxylates including lactate and pyruvate, short-chain fatty acids, ketone bodies, nicotinate and its structural analogs, pyroglutamate, benzoate and its derivatives, and iodide. Human SMCT1 (hSMCT1, also called AIT) is encoded by the tumor suppressor gene SLC5A8. SMCT1 is expressed in the colon, small intestine, kidney, thyroid gland, retina, and brain. SMCT1 may contribute to the intestinal/colonic and oral absorption of monocarboxylate drugs. It also mediates iodide transport from thyrocyte into the colloid lumen in thyroid gland and, through transporting L-lactate and ketone bodies, helps maintain the energy status and the function of neurons. SMCT2 is a low-affinity transporter for short-chain fatty acids, lactate, pyruvate, and nicotinate. hSMCT2 is encoded by the SLC5A12 gene. SMCT2 is expressed in the kidney, small intestine, skeletal muscle, and retina. In the kidney, SMCT2 may initiate lactate absorption in the early parts of the tubule, SMCT1 in the latter parts of the tubule. In the retina, SMCT1 and SMCT2 may play a differential role in monocarboxylate transport in a cell type-specific manner. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271395  Cd Length: 538  Bit Score: 99.96  E-value: 5.41e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620  12 FFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWTSSVMLLILGWIFVPIYIKSGVMTMPEYLKKRFg 91
Cdd:cd11505   39 FLMGGRQMTAVPVALSLTASFMSAVTVLGTPSEVYRFGASFLIFAFAYLFVVLISSEVFLPVFYRLGITSTYEYLELRF- 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620  92 gERLQVYLSILSLFICVVLLISADIFAGAIFIKLALGLDLYLAIFILLAMTAVYTTTGGLASVIYTDTLQTIIMLIGSFI 171
Cdd:cd11505  118 -NKPVRLAGTVLFIVQTILYTGIVIYAPALALNQVTGFDLWGAVVATGVVCTFYCTLGGLKAVVWTDVFQVGIMVAGFLS 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 172 LMGFAFNEVGGYESFTEKYVNatpsvveGDNLTISAscYTPRADSFHIFrdavtgdipWPgIIFGMPITALWYWCTNQVI 251
Cdd:cd11505  197 VIIQAVVHQGGIHNILNDSYN-------GSRLNFWD--FDPNPLRRHTF---------WT-ITVGGTFTWTGIYGVNQSQ 257

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 252 VQRCLCGKDMSHVKaaciMCAYLKLLPMFLM----VMPGMISRILYTDmvacvvpseCVKHCGVDVGCTNYAYPTMVLEL 327
Cdd:cd11505  258 VQRYISCKTRFQAK----LSLYFNLLGLWAIlvcaVFSGLAMYSHYKD---------CDPWTAKIVSAPDQLMPYLVLDI 324

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 328 MPQ--GLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKMRKQASEKELLIAGRIFVLLLTVVSIVWVPLVQVSqnGQ 405
Cdd:cd11505  325 LADypGLPGLFVACAYSGTLSTVSSSINALAAVTVEDLIKPYFRSLSEKLSSWISKGLSLLYGAMCIGMAVAASLM--GG 402

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 768025620 406 LIHYTESISSYLGPPIAAVFVLAIFCKRVNEQGAFWGLMVGLAMGLIRMITEFAY 460
Cdd:cd11505  403 LLQAALSIFGMVGGPLLGLFSLGILFPFVNSKGALGGLLTGFAISLWVGIGAQIY 457
SLC5sbd_PanF cd10327
Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute ...
 12-506 2.89e-21

Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; PanF catalyzes the Na+-coupled uptake of extracellular pantothenate for coenzyme A biosynthesis in cells. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 212037  Cd Length: 472  Bit Score: 97.28  E-value: 2.89e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620  12 FFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWTSSVM----LLILGWIFVPIYIKSGVMTMPEYLK 87
Cdd:cd10327   34 YFIGGRSMGGFVLAMTLVATYTSASSFIGGPGAAYKIGLGWVLLAMIQVPTgfltLGVLGKKFAIIARKINAVTIIDYLR 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620  88 KRFGGERLqVYLSILSLFICVVLLISADIFAGAIFIKLALGLDLYLAIFILLAMTAVYTTTGGLASVIYTDTLQTIIMLI 167
Cdd:cd10327  114 ARYNSKAL-VVLSSLALIVFFIAAMVAQFIGGARLLEAVTGLSYVTGLLIFGLTVILYTTIGGFRAVALTDAIQGIVMII 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 168 GSFILMGFAFNEVGGYESFTEKYVNATPSVVE---GDNLTIsascytPRADSFHIFrdavtgdipwPGI-IFGMPITAlw 243
Cdd:cd10327  193 GTVLLLVGVLAAGGGMEAIMATLAEIDPNLLTpfgPGFLSP------PYILSFWVL----------VGFgVIGLPQTA-- 254

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 244 ywctnqvivQRCLCGKDMSHVKAACIMCAYLKLLPMFLMVMPGMISRILYTDMvacvvpsecvkhcgvDVGctNYAYPTM 323
Cdd:cd10327  255 ---------VRCMGYKDSKSMHRAMIIGTVVVGFLMLGMHLAGVLGRAVLPDL---------------EVP--DKVIPTL 308

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 324 VLELMPQGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLY---TKMRKQASEKEL----LIAGRIFVLLLTVVS----- 391
Cdd:cd10327  309 ALKVLPPWLAGLFLAGPLAAIMSTVDSQLILASSAIVKDLYlnyKNKEKKTSEKKVkrisLIITIILGLLVFLLAinppd 388

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 392 -IVWVPLVQVsqnGQLihytesISSYLGPpiaavFVLAIFCKRVNEQGAFWGLMVGLamglirmitefaygtGSCLAPSN 470
Cdd:cd10327  389 lIVWLNLFAF---GGL------EAAFFWP-----LVLGLYWKRANATGALASMVVGL---------------VSYILITY 439

                        490       500       510
                 ....*....|....*....|....*....|....*.
gi 768025620 471 CPKIICGVHYLYFSIVLffgSMLVTLGISLLTKPIP 506
Cdd:cd10327  440 LKIKILGLHPIVPSLLL---SLIAFIIVSLATKKPD 472
SLC5sbd_SMCT1 cd11519
Na(+)/monocarboxylate cotransporter SMCT1 and related proteins; solute-binding domain; SMCT1 ...
 12-451 2.05e-20

Na(+)/monocarboxylate cotransporter SMCT1 and related proteins; solute-binding domain; SMCT1 is a high-affinity transporter of various monocarboxylates including lactate and pyruvate, short-chain fatty acids, ketone bodies, nicotinate and its structural analogs, pyroglutamate, benzoate and its derivatives, and iodide. Human SMCT1 (hSMCT1, also called AIT) is encoded by the tumor suppressor gene SLC5A8. Its expression is under the control of the C/EBP transcription factor. Its tumor-suppressive role is related to uptake of butyrate, propionate, and pyruvate, these latter are inhibitors of histone deacetylases. SMCT1 is expressed in the colon, small intestine, kidney, thyroid gland, retina, and brain. SMCT1 may contribute to the intestinal/colonic and oral absorption of monocarboxylate drugs. SMCT1 also mediates iodide transport from thyrocyte into the colloid lumen in thyroid gland and through transporting l-lactate and ketone bodies helps maintain the energy status and the function of neurons. In the kidney its expression is limited to the S3 segment of the proximal convoluted tubule (in contrast to the low-affinity monocarboxylate transporter SMCT2, belonging to a different family, which is expressed along the entire length of the tubule). In the retina, SMCT1 and SMCT2 may play a differential role in monocarboxylate transport in a cell type-specific manner, SMCT1 is expressed predominantly in retinal neurons and in retinal pigmented epithelial (RPE) cells. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271402  Cd Length: 542  Bit Score: 94.91  E-value: 2.05e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620  12 FFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWTSSVMLLILGWIFVPIYIKSGVMTMPEYLKKRFG 91
Cdd:cd11519   39 FLMGGRQMTAVPVALSLTASFMSAVTVLGTPAEVYRFGAIFSIFAFTYAIVVVISAEVFLPVFYRLGITSTYEYLELRFN 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620  92 GerlQVYLSILSLFIC-VVLLISADIFAGAIFIKLALGLDLYLAIFILLAMTAVYTTTGGLASVIYTDTLQTIIMligsf 170
Cdd:cd11519  119 K---CVRLIGTSLFIVqTALYTGIVIYAPALALNQVTGFDLWGAVVATGVVCTFYCTLGGLKAVIWTDVFQVGIM----- 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 171 ilmgfafneVGGYESftekyVNATPSVVEGDNLTI-SASCYTPRADSFHIFRDAVTGDIPWPgIIFGMPITALWYWCTNQ 249
Cdd:cd11519  191 ---------VAGFVS-----VIIRAVVLQGGIGTIlNDSYYGGRLNFWDFDPNPLQRHTFWT-IVIGGTFTWTSIYGVNQ 255

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 250 VIVQRCLCGKDMSHVKaaciMCAYLKLLPMFLMVMPGMISRI-LYTdmvacvVPSECVKHCGVDVGCTNYAYPTMVLELM 328
Cdd:cd11519  256 SQVQRYISCKTRFQAK----MSLYVNLVGLWAILSCAVLSGLaMYS------IYKDCDPWTAKDVSAPDQLMPYLVLDIL 325

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 329 PQ--GLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKMRKQASEKELLIAGRIFVLLLTVVSIVWVPLvqVSQNGQL 406
Cdd:cd11519  326 ADypGLPGLFVACAYSGTLSTVSSSINALAAVTVEDLIKPYFRSLSERQLSWISMGMSVFYGALCIGMAGL--ASLMGAL 403

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*
gi 768025620 407 IHYTESISSYLGPPIAAVFVLAIFCKRVNEQGAFWGLMVGLAMGL 451
Cdd:cd11519  404 LQAALSIFGMVGGPLLGLFALGILFPFANSIGALVGLMSGFAISL 448
SLC5sbd_NIS cd11503
Na(+)/iodide cotransporter NIS and related proteins; solute-binding domain; NIS (product of ...
 6-451 3.11e-16

Na(+)/iodide cotransporter NIS and related proteins; solute-binding domain; NIS (product of the SLC5A5 gene) transports I-, and other anions including ClO4-, SCN-, and Br-. NIS is expressed in the thyroid, colon, ovary, and in human breast cancers. It mediates the active transport and the concentration of iodide from the blood into thyroid follicular cells, a fundamental step in thyroid hormone biosynthesis, and is the basis of radioiodine therapy for thyroid cancer. Mutation in the SLC5A5 gene can result in a form of thyroid hormone dysgenesis. Human NIS exists mainly as a dimer stabilized by a disulfide bridge. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271393  Cd Length: 535  Bit Score: 81.81  E-value: 3.11e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620   6 RGTIGGFFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWTSSVMLLILGWIFVPIYIKSGVMTMPEY 85
Cdd:cd11503   27 QRSADDFFTGGRGLSAVPVGLSLSASFMSAVQVLGVPSEAYRYGLKFLWMCLGQLLNSLMTAVLFMPVFYRLGITSTYQY 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620  86 LKKRFGgeRLQVYLSILSLFICVVLLISADIFAGAIFIKLALGLDLYLAIFILLAMTAVYTTTGGLASVIYTDTLQTIIM 165
Cdd:cd11503  107 LEMRFS--RAVRLCGTLQFIVATMLYTGIVIYAPALILNQVTGLDIWASLFSTGIICTFYTTVGGMKAVIWTDVFQVVVM 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 166 LIGSFILMGFAFNEVGGYESFTEkyvnatpsvVEGDNLTISASCYTPRADSFHIFrdavtgdipWPGIIFGmpiTALW-- 243
Cdd:cd11503  185 LSGFWAVLIRGVILVGGPRRVLE---------IAQNHSRINFMDFDPDPRRRYTF---------WTFVVGG---TLVWls 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 244 YWCTNQVIVQRCLCGKDMSHVKAACImcayLKLLPMFLMVMPGMISRIlytdmVACVVPSECVKHCGVDVGCTNYAYPTM 323
Cdd:cd11503  244 MYGVNQAQVQRYVACRTEKQAKLALL----VNQVGLCLIVSSAATCGI-----VMFVYYSNCDPLLIGRISAPDQYMPYL 314

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 324 VLELMPQ--GLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKMRKQASEKELLIAGRIFVLLLTVVSIVWVPLVQVS 401
Cdd:cd11503  315 VLDIFEDlpGVPGLFLACAYSGTLSTASTSINAMAAVTVEDLIKPRLPTIAPRKLVFISKGLSLIYGSACITVAALSSLL 394

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|
gi 768025620 402 QNGQLiHYTESISSYLGPPIAAVFVLAIFCKRVNEQGAFWGLMVGLAMGL 451
Cdd:cd11503  395 GGGVL-QGSFTVMGVISGPLLGAFALGMFLPACNTPGVFSGLAVGLALSL 443
SLC5sbd_u4 cd11480
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ...
 8-448 1.61e-14

Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271374  Cd Length: 488  Bit Score: 76.39  E-value: 1.61e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620   8 TIGGFFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFE--WTSSVMLLILgwIFVPIYIKSGVMTMPEY 85
Cdd:cd11480   24 STSDFYVAGRGVPPVQNGLAIAGDYMSAASFLGIAGLIALSGYDGLAYAigWTGGYVLLLL--LVAEPLRNFGKYTVPDF 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620  86 LKKRFGGERLQVYLSILSLFICVVLLIsADIFAGAIFIKLALGLDLYLAIFILLAMTAVYTTTGGLASVIYTDTLQTIIM 165
Cdd:cd11480  102 LGARLGSRPVRLVAAVSTLVISFFYLV-AQMVGAGLLLSLLLGIPYEVGVVVVGALMIVYVVLGGMRATTWVQIIQYVLL 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 166 LIGSFILMGFAFNEVGGYesftekyvnatPSVVEGDNLTISASCYTPRADSFHIFRDAVTGDIPWPGIIFGMPI-TAlwy 244
Cdd:cd11480  181 LGAFLVPAILVLARFGGN-----------PLGAGPGLLGLAAAAASGAGEAYLAPGLLLTDPLDVISLTLALMLgTA--- 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 245 wCTNQVIVqRCLCGKDM-----SHVKAACIMCAYLkllpmFLMVMPGMISRIL-YTDMVACVVPSECVKHcgvdvgcTNY 318
Cdd:cd11480  247 -GLPHVLM-RFYTVPDAraarkSVVWALGFIGLFY-----LLAPALGFGARALvGPDVIGAPIAGELDGG-------GDM 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 319 AYPTMVLEL-MPQGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKM-RKQASEKELLIAGRIFVLLLTVVSIvWVP 396
Cdd:cd11480  313 AVLLLPEIAgLGDLLLALVAAGAFAAILATVAGLLLAAASALAHDLYAGViRPGASERREVRVARIAAVVVGVIAI-LLA 391

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 768025620 397 LVQVSQN-GQLIHYTESI--SSylgppIAAVFVLAIFCKRVNEQGAFWGLMVGLA 448
Cdd:cd11480  392 LLFPPQNvAFLVALAFAIaaSA-----FFPVLVLGIFWRRFTTRGAIAGMLVGLL 441
PRK15419 PRK15419
sodium/proline symporter PutP;
12-462 7.64e-11

sodium/proline symporter PutP;


Pssm-ID: 185317  Cd Length: 502  Bit Score: 64.65  E-value: 7.64e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620  12 FFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVAT--VTFEWTSSVML---LILGWIFVPIYIKSGVMTMPEYL 86
Cdd:PRK15419  35 YILGGRSLGPFVTALSAGASDMSGWLLMGLPGAVFLSGISEswIAIGLTLGAWInwkLVAGRLRVHTEYNNNALTLPDYF 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620  87 KKRF-GGERLQVYLSILSLFICVVLLISADIFAGAIFIKLALGLDLYLAIFILLAMTAVYTTTGGLASVIYTDTLQTIIM 165
Cdd:PRK15419 115 TGRFeDKSRILRIISALVILLFFTIYCASGIVAGARLFESTFGMSYETALWAGAAATILYTFIGGFLAVSWTDTVQASLM 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 166 LIGSFILMGFAFNEVGGY----ESFTEKYVNATpSVVEGDNLTisascytpradsfhifrdAVTGDIPWPGIIFGMPita 241
Cdd:PRK15419 195 IFALILTPVIVIISVGGFgdslEVIKQKSIENV-DMLKGLNFV------------------AIISLMGWGLGYFGQP--- 252

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 242 lwywctnqVIVQRCLCGKDMSHVKAAcimcaylkllpmflmvmpgmiSRILYTDMVACVVPSECVKHCGV--------DV 313
Cdd:PRK15419 253 --------HILARFMAADSHHSIVHA---------------------RRISMTWMILCLAGAVAVGFFGIayfnehpaVA 303

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 314 GCTNYAYPTMVLEL----MPQGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTK-MRKQASEKELLIAGRIFVLllt 388
Cdd:PRK15419 304 GAVNQNAERVFIELaqilFNPWIAGILLSAILAAVMSTLSCQLLVCSSAITEDLYKAfLRKHASQKELVWVGRVMVL--- 380

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025620 389 VVSIVWVPLVQVSQNGQLIHYTESISSYlGPPIAAVFVLAIFCKRVNEQGAFWGLMVGLA----------MGLIRMITEF 458
Cdd:PRK15419 381 VVALVAIALAANPENRVLGLVSYAWAGF-GAAFGPVVLFSVMWSRMTRNGALAGMIIGALtvivwkqfgwLGLYEIIPGF 459


                 ....
gi 768025620 459 AYGT 462
Cdd:PRK15419 460 IFGS 463
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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