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Conserved domains on  [gi|767964236|ref|XP_011538642|]
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cadherin-related family member 1 isoform X4 [Homo sapiens]

Protein Classification

cadherin repeat domain-containing protein( domain architecture ID 10182011)

cadherin repeat domain-containing protein similar to Homo sapiens desmoglein-2, which is involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion; cadherins are are calcium-dependent cell adhesion proteins that preferentially interact with themselves in connecting cells

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  17158740|28268172|27782885|11736639
SCOP:  4007535

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 197-299 9.09e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.40  E-value: 9.09e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964236 197 PYVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFL--QNLHSPFAVDRHSGVLRLQagATLDYERSRTHYITVVAKDGG 274
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvsGNEDGLFSIDPSTGEITTA--KPLDREEQSSYTLTVTATDGG 78

                         90       100
                 ....*....|....*....|....*
gi 767964236 275 GRlhgadvVFSATTTVTVNVEDVQD 299
Cdd:cd11304   79 GP------PLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 535-630 2.15e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 106.24  E-value: 2.15e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964236 535 YVARIPENAPGGSSVVAVTAVDPDTGPWGEVKYS-TYGTGADLFLIHPSTGLIYTQpwASLDAEATARYNFYVKAEDMEG 613
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSiVSGNEDGLFSIDPSTGEITTA--KPLDREEQSSYTLTVTATDGGG 79

                         90
                 ....*....|....*....
gi 767964236 614 --KYSVAEVFITLLDVNDH 630
Cdd:cd11304   80 ppLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 308-407 1.12e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.46  E-value: 1.12e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964236 308 PYYGYVYEDTLPGSEVLKVVAMDGDRGKPNRILYSLVNGN-DGAFEINETSGAISITQSpaqLQRE---VYELHVQVTEM 383
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNeDGLFSIDPSTGEITTAKP---LDREeqsSYTLTVTATDG 77

                         90       100
                 ....*....|....*....|....
gi 767964236 384 spaGSPAAQATVPVTIRIVDLNNH 407
Cdd:cd11304   78 ---GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 421-526 8.50e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 61.95  E-value: 8.50e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964236 421 FELSMNEHPPQGEILrgLKITVNDSDQGANAKFNLQLVG--PRGIFRVVPQTvlneAQVTIIvensAAIDFEKSKVLTFK 498
Cdd:cd11304    2 YEVSVPENAPPGTVV--LTVSATDPDSGENGEVTYSIVSgnEDGLFSIDPST----GEITTA----KPLDREEQSSYTLT 71

                         90       100
                 ....*....|....*....|....*...
gi 767964236 499 LLAVEVNTPeKFSSTADVVIQLLDTNDN 526
Cdd:cd11304   72 VTATDGGGP-PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 100-188 3.04e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 60.40  E-value: 3.04e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964236 100 FSLPEDTPVGSHVYTLNGTDP---EGDPISYHISfDPSTRSVFSVDPTFGNITLVEELDREREDEIEAIISISDGLNLVA 176
Cdd:cd11304    4 VSVPENAPPGTVVLTVSATDPdsgENGEVTYSIV-SGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                         90
                 ....*....|....*
gi 767964236 177 E---KVVILVTDAND 188
Cdd:cd11304   83 SstaTVTITVLDVND 97
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 197-299 9.09e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.40  E-value: 9.09e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964236 197 PYVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFL--QNLHSPFAVDRHSGVLRLQagATLDYERSRTHYITVVAKDGG 274
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvsGNEDGLFSIDPSTGEITTA--KPLDREEQSSYTLTVTATDGG 78

                         90       100
                 ....*....|....*....|....*
gi 767964236 275 GRlhgadvVFSATTTVTVNVEDVQD 299
Cdd:cd11304   79 GP------PLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 535-630 2.15e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 106.24  E-value: 2.15e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964236 535 YVARIPENAPGGSSVVAVTAVDPDTGPWGEVKYS-TYGTGADLFLIHPSTGLIYTQpwASLDAEATARYNFYVKAEDMEG 613
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSiVSGNEDGLFSIDPSTGEITTA--KPLDREEQSSYTLTVTATDGGG 79

                         90
                 ....*....|....*....
gi 767964236 614 --KYSVAEVFITLLDVNDH 630
Cdd:cd11304   80 ppLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 308-407 1.12e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.46  E-value: 1.12e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964236 308 PYYGYVYEDTLPGSEVLKVVAMDGDRGKPNRILYSLVNGN-DGAFEINETSGAISITQSpaqLQRE---VYELHVQVTEM 383
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNeDGLFSIDPSTGEITTAKP---LDREeqsSYTLTVTATDG 77

                         90       100
                 ....*....|....*....|....
gi 767964236 384 spaGSPAAQATVPVTIRIVDLNNH 407
Cdd:cd11304   78 ---GGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
535-625 2.89e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 80.04  E-value: 2.89e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964236  535 YVARIPENAPGGSSVVAVTAVDPDTGPWGEVKYS-TYGTGADLFLIHPSTGLIYTQpwASLDAEATARYNFYVKAEDM-- 611
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSiLGGGPGGNFRIDPDTGDISTT--KPLDRESIGEYELTVEATDSgg 78

                          90
                  ....*....|....
gi 767964236  612 EGKYSVAEVFITLL 625
Cdd:pfam00028  79 PPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 553-632 1.31e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.78  E-value: 1.31e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964236   553 TAVDPDTGPWGEVKYS-TYGTGADLFLIHPSTGLIYTQpwASLDAEATARYNFYVKAEDMEG--KYSVAEVFITLLDVND 629
Cdd:smart00112   1 SATDADSGENGKVTYSiLSGNDDGLFSIDPETGEITTT--KPLDREEQPEYTLTVEATDGGGppLSSTATVTITVLDVND 78


                   ...
gi 767964236   630 HPP 632
Cdd:smart00112  79 NAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 216-302 2.46e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.00  E-value: 2.46e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964236   216 HAVDRDTGSGGSVTYFL--QNLHSPFAVDRHSGVLRLQAgaTLDYERSRTHYITVVAKDGGGRLHgadvvfSATTTVTVN 293
Cdd:smart00112   1 SATDADSGENGKVTYSIlsGNDDGLFSIDPETGEITTTK--PLDREEQPEYTLTVEATDGGGPPL------SSTATVTIT 72


                   ....*....
gi 767964236   294 VEDVQDMAP 302
Cdd:smart00112  73 VLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
198-295 1.50e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 75.03  E-value: 1.50e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964236  198 YVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQNLHSP--FAVDRHSGVLRLQagATLDYERSRTHYITVVAKDGGG 275
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGgnFRIDPDTGDISTT--KPLDRESIGEYELTVEATDSGG 78

                          90       100
                  ....*....|....*....|
gi 767964236  276 RlhgadvVFSATTTVTVNVE 295
Cdd:pfam00028  79 P------PLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 327-409 5.52e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 64.68  E-value: 5.52e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964236   327 VAMDGDRGKPNRILYSLVNGND-GAFEINETSGAISITqspAQLQRE---VYELHVQVTEMspaGSPAAQATVPVTIRIV 402
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDdGLFSIDPETGEITTT---KPLDREeqpEYTLTVEATDG---GGPPLSSTATVTITVL 74


                   ....*..
gi 767964236   403 DLNNHPP 409
Cdd:smart00112  75 DVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 421-526 8.50e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 61.95  E-value: 8.50e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964236 421 FELSMNEHPPQGEILrgLKITVNDSDQGANAKFNLQLVG--PRGIFRVVPQTvlneAQVTIIvensAAIDFEKSKVLTFK 498
Cdd:cd11304    2 YEVSVPENAPPGTVV--LTVSATDPDSGENGEVTYSIVSgnEDGLFSIDPST----GEITTA----KPLDREEQSSYTLT 71

                         90       100
                 ....*....|....*....|....*...
gi 767964236 499 LLAVEVNTPeKFSSTADVVIQLLDTNDN 526
Cdd:cd11304   72 VTATDGGGP-PLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
309-401 8.88e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 61.55  E-value: 8.88e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964236  309 YYGYVYEDTLPGSEVLKVVAMDGDRGKPNRILYSLVNGN-DGAFEINETSGAISITQspaQLQREV---YELHVQVTEms 384
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGpGGNFRIDPDTGDISTTK---PLDRESigeYELTVEATD-- 75

                          90
                  ....*....|....*..
gi 767964236  385 pAGSPAAQATVPVTIRI 401
Cdd:pfam00028  76 -SGGPPLSSTATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 100-188 3.04e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 60.40  E-value: 3.04e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964236 100 FSLPEDTPVGSHVYTLNGTDP---EGDPISYHISfDPSTRSVFSVDPTFGNITLVEELDREREDEIEAIISISDGLNLVA 176
Cdd:cd11304    4 VSVPENAPPGTVVLTVSATDPdsgENGEVTYSIV-SGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                         90
                 ....*....|....*
gi 767964236 177 E---KVVILVTDAND 188
Cdd:cd11304   83 SstaTVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 441-528 1.13e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 55.05  E-value: 1.13e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964236   441 TVNDSDQGANAKFNLQLVG--PRGIFRVVPQTvlneaqvtIIVENSAAIDFEKSKVLTFKLLAVEVNTPEKfSSTADVVI 518
Cdd:smart00112   1 SATDADSGENGKVTYSILSgnDDGLFSIDPET--------GEITTTKPLDREEQPEYTLTVEATDGGGPPL-SSTATVTI 71

                           90
                   ....*....|
gi 767964236   519 QLLDTNDNVP 528
Cdd:smart00112  72 TVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
100-153 1.75e-03

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 38.05  E-value: 1.75e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 767964236  100 FSLPEDTPVGSHVYTLNGTDPEGDP---ISYHISFDPSTRSvFSVDPTFGNITLVEE 153
Cdd:pfam00028   3 ASVPENAPVGTEVLTVTATDPDLGPngrIFYSILGGGPGGN-FRIDPDTGDISTTKP 58
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 119-191 3.19e-03

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 36.94  E-value: 3.19e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767964236   119 DPEGDPISYHISfDPSTRSVFSVDPTFGNITLVEELDREREDEIEAIISISDG--LNLVAE-KVVILVTDANDEAP 191
Cdd:smart00112   7 SGENGKVTYSIL-SGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGggPPLSSTaTVTITVLDVNDNAP 81
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 197-299 9.09e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.40  E-value: 9.09e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964236 197 PYVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFL--QNLHSPFAVDRHSGVLRLQagATLDYERSRTHYITVVAKDGG 274
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvsGNEDGLFSIDPSTGEITTA--KPLDREEQSSYTLTVTATDGG 78

                         90       100
                 ....*....|....*....|....*
gi 767964236 275 GRlhgadvVFSATTTVTVNVEDVQD 299
Cdd:cd11304   79 GP------PLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 535-630 2.15e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 106.24  E-value: 2.15e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964236 535 YVARIPENAPGGSSVVAVTAVDPDTGPWGEVKYS-TYGTGADLFLIHPSTGLIYTQpwASLDAEATARYNFYVKAEDMEG 613
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSiVSGNEDGLFSIDPSTGEITTA--KPLDREEQSSYTLTVTATDGGG 79

                         90
                 ....*....|....*....
gi 767964236 614 --KYSVAEVFITLLDVNDH 630
Cdd:cd11304   80 ppLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 308-407 1.12e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.46  E-value: 1.12e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964236 308 PYYGYVYEDTLPGSEVLKVVAMDGDRGKPNRILYSLVNGN-DGAFEINETSGAISITQSpaqLQRE---VYELHVQVTEM 383
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNeDGLFSIDPSTGEITTAKP---LDREeqsSYTLTVTATDG 77

                         90       100
                 ....*....|....*....|....
gi 767964236 384 spaGSPAAQATVPVTIRIVDLNNH 407
Cdd:cd11304   78 ---GGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
535-625 2.89e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 80.04  E-value: 2.89e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964236  535 YVARIPENAPGGSSVVAVTAVDPDTGPWGEVKYS-TYGTGADLFLIHPSTGLIYTQpwASLDAEATARYNFYVKAEDM-- 611
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSiLGGGPGGNFRIDPDTGDISTT--KPLDRESIGEYELTVEATDSgg 78

                          90
                  ....*....|....
gi 767964236  612 EGKYSVAEVFITLL 625
Cdd:pfam00028  79 PPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 553-632 1.31e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.78  E-value: 1.31e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964236   553 TAVDPDTGPWGEVKYS-TYGTGADLFLIHPSTGLIYTQpwASLDAEATARYNFYVKAEDMEG--KYSVAEVFITLLDVND 629
Cdd:smart00112   1 SATDADSGENGKVTYSiLSGNDDGLFSIDPETGEITTT--KPLDREEQPEYTLTVEATDGGGppLSSTATVTITVLDVND 78


                   ...
gi 767964236   630 HPP 632
Cdd:smart00112  79 NAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 216-302 2.46e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.00  E-value: 2.46e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964236   216 HAVDRDTGSGGSVTYFL--QNLHSPFAVDRHSGVLRLQAgaTLDYERSRTHYITVVAKDGGGRLHgadvvfSATTTVTVN 293
Cdd:smart00112   1 SATDADSGENGKVTYSIlsGNDDGLFSIDPETGEITTTK--PLDREEQPEYTLTVEATDGGGPPL------SSTATVTIT 72


                   ....*....
gi 767964236   294 VEDVQDMAP 302
Cdd:smart00112  73 VLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
198-295 1.50e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 75.03  E-value: 1.50e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964236  198 YVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQNLHSP--FAVDRHSGVLRLQagATLDYERSRTHYITVVAKDGGG 275
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGgnFRIDPDTGDISTT--KPLDRESIGEYELTVEATDSGG 78

                          90       100
                  ....*....|....*....|
gi 767964236  276 RlhgadvVFSATTTVTVNVE 295
Cdd:pfam00028  79 P------PLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 327-409 5.52e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 64.68  E-value: 5.52e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964236   327 VAMDGDRGKPNRILYSLVNGND-GAFEINETSGAISITqspAQLQRE---VYELHVQVTEMspaGSPAAQATVPVTIRIV 402
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDdGLFSIDPETGEITTT---KPLDREeqpEYTLTVEATDG---GGPPLSSTATVTITVL 74


                   ....*..
gi 767964236   403 DLNNHPP 409
Cdd:smart00112  75 DVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 421-526 8.50e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 61.95  E-value: 8.50e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964236 421 FELSMNEHPPQGEILrgLKITVNDSDQGANAKFNLQLVG--PRGIFRVVPQTvlneAQVTIIvensAAIDFEKSKVLTFK 498
Cdd:cd11304    2 YEVSVPENAPPGTVV--LTVSATDPDSGENGEVTYSIVSgnEDGLFSIDPST----GEITTA----KPLDREEQSSYTLT 71

                         90       100
                 ....*....|....*....|....*...
gi 767964236 499 LLAVEVNTPeKFSSTADVVIQLLDTNDN 526
Cdd:cd11304   72 VTATDGGGP-PLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
309-401 8.88e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 61.55  E-value: 8.88e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964236  309 YYGYVYEDTLPGSEVLKVVAMDGDRGKPNRILYSLVNGN-DGAFEINETSGAISITQspaQLQREV---YELHVQVTEms 384
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGpGGNFRIDPDTGDISTTK---PLDRESigeYELTVEATD-- 75

                          90
                  ....*....|....*..
gi 767964236  385 pAGSPAAQATVPVTIRI 401
Cdd:pfam00028  76 -SGGPPLSSTATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 100-188 3.04e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 60.40  E-value: 3.04e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964236 100 FSLPEDTPVGSHVYTLNGTDP---EGDPISYHISfDPSTRSVFSVDPTFGNITLVEELDREREDEIEAIISISDGLNLVA 176
Cdd:cd11304    4 VSVPENAPPGTVVLTVSATDPdsgENGEVTYSIV-SGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                         90
                 ....*....|....*
gi 767964236 177 E---KVVILVTDAND 188
Cdd:cd11304   83 SstaTVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 441-528 1.13e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 55.05  E-value: 1.13e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964236   441 TVNDSDQGANAKFNLQLVG--PRGIFRVVPQTvlneaqvtIIVENSAAIDFEKSKVLTFKLLAVEVNTPEKfSSTADVVI 518
Cdd:smart00112   1 SATDADSGENGKVTYSILSgnDDGLFSIDPET--------GEITTTKPLDREEQPEYTLTVEATDGGGPPL-SSTATVTI 71

                           90
                   ....*....|
gi 767964236   519 QLLDTNDNVP 528
Cdd:smart00112  72 TVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
100-153 1.75e-03

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 38.05  E-value: 1.75e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 767964236  100 FSLPEDTPVGSHVYTLNGTDPEGDP---ISYHISFDPSTRSvFSVDPTFGNITLVEE 153
Cdd:pfam00028   3 ASVPENAPVGTEVLTVTATDPDLGPngrIFYSILGGGPGGN-FRIDPDTGDISTTKP 58
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 119-191 3.19e-03

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 36.94  E-value: 3.19e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767964236   119 DPEGDPISYHISfDPSTRSVFSVDPTFGNITLVEELDREREDEIEAIISISDG--LNLVAE-KVVILVTDANDEAP 191
Cdd:smart00112   7 SGENGKVTYSIL-SGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGggPPLSSTaTVTITVLDVNDNAP 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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