transforming growth factor beta (TGF-beta) like domain found in TGF-beta superfamily; TGF-beta superfamily consists of a large group of cell regulatory proteins, such as TFG-betas, Nodal, Activins/Inhibins, glial cell-line-derived neurotrophic factor (GDNF) family of ligands, bone morphogenetic proteins (BMPs), and growth and differentiation factors (GDFs). They play important roles in developmental and physiological processes in a variety of species, including invertebrates as well as vertebrates, through specific receptor complexes that are composed of type I and type II serine/threonine receptor kinases. The receptor kinases subsequently activate Smad proteins, which then propagate the signals into the nucleus to regulate target gene expression. Proteins from the TGF-beta superfamily are only active as homo- or heterodimer.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767905740 298 RQVCRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSL 353
Cdd:cd19398    1 RQVCKRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSL 56

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 8A (BMP-8A), 8B (BMP-8B) and similar proteins; BMP-8A plays a role in the maintenance of spermatogenesis and the integrity of the epididymis. BMP-8B, also termed BMP-8, or osteogenic protein 2 (OP-2), may act as secreted factor in cancer progression. It also plays an essential role in bone metabolism and can regulate thermogenesis and energy balance. Like BMP-8A, BMP-8B plays a role in spermatogenesis and placental development. Mutation in either of the genes encoding BMP-8A or BMP-8B causes postnatal depletion of spermatogonia in mice.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767905740 298 RQVCRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSL 353
Cdd:cd19398    1 RQVCKRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSL 56

Transforming growth factor beta like domain;

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 767905740  301 CRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSL 353
Cdd:pfam00019   2 CRRHSLYVDFEDLGWDDWIIAPKGYNAYYCSGSCPSHLNPQLSATNHAILQSL 54

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 8A (BMP-8A), 8B (BMP-8B) and similar proteins; BMP-8A plays a role in the maintenance of spermatogenesis and the integrity of the epididymis. BMP-8B, also termed BMP-8, or osteogenic protein 2 (OP-2), may act as secreted factor in cancer progression. It also plays an essential role in bone metabolism and can regulate thermogenesis and energy balance. Like BMP-8A, BMP-8B plays a role in spermatogenesis and placental development. Mutation in either of the genes encoding BMP-8A or BMP-8B causes postnatal depletion of spermatogonia in mice.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767905740 298 RQVCRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSL 353
Cdd:cd19398    1 RQVCKRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSL 56

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 7 (BMP-7) and similar proteins; BMP-7, also termed osteogenic protein 1 (OP-1), or eptotermin alfa, induces cartilage and bone formation. It may act as the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis and play a role in calcium regulation and bone homeostasis.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767905740 298 RQVCRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSL 353
Cdd:cd19397    3 RQACKKHELYVSFRDLGWQDWIIAPEGYAAYYCEGECAFPLNSYMNATNHAIVQTL 58

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 5 (BMP-5) and similar proteins; BMP-5 induces cartilage and bone formation.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767905740 291 DVHGSHGRQVCRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSL 353
Cdd:cd19395    2 DYNTSEQKQACKKHELYVSFRDLGWQDWIIAPEGYAAFYCDGECSFPLNAHMNATNHAIVQTL 64

Transforming growth factor beta like domain;

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 767905740  301 CRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSL 353
Cdd:pfam00019   2 CRRHSLYVDFEDLGWDDWIIAPKGYNAYYCSGSCPSHLNPQLSATNHAILQSL 54

transforming growth factor beta (TGF-beta) like domain found in Strongylocentrotus purpuratus univin and similar proteins; Univin may have a critical role in early developmental decisions in the sea urchin embryo.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767905740 300 VCRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSL 353
Cdd:cd19387    2 ICQRHSLYVDFKDVGWSDWIIAPRGYQAYRCAGECPFPLNEHLNGTNHAIIQTL 55

transforming growth factor beta (TGF-beta) like domain found in Drosophila melanogaster protein decapentaplegic (Dpp) and similar proteins; decapentaplegic (Dpp) and similar proteins Dpp, also termed as protein DPP-C, is required later in embryogenesis for dorsal closure and patterning of the hindgut. It also functions postembryonically as a long-range morphogen during imaginal disk development and is responsible for the progression of the morphogenetic furrow during eye development.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767905740 298 RQVCRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSL 353
Cdd:cd19392    5 QNLCRRHPLYVDFSDVGWDDWIVAPLGYDAYYCNGECPFPLADYLNATNHAVVQTL 60

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 2 (BMP-2) and similar proteins; BMP-2, also termed BMP-2A, induces cartilage and bone formation. It stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 767905740 301 CRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSL 353
Cdd:cd19390    3 CKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTL 55

transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 5 (GDF5), factor 6 (GDF6), factor 7 (GDF7) and similar proteins; The family includes GDF5, GDF6 and GDF7. GDF5, also termed bone morphogenetic protein 14 (BMP-14), or cartilage-derived morphogenetic protein 1 (CDMP-1), or lipopolysaccharide-associated protein 4 (LAP-4), or LPS-associated protein 4, or radotermin, is a growth factor involved in bone and cartilage formation. GDF6, also termed bone morphogenetic protein 13 (BMP-13), or growth/differentiation factor 16, is a growth factor that controls proliferation and cellular differentiation in the retina and bone formation. GDF7, also termed bone morphogenetic protein 12 (BMP-12), may play an active role in the motor area of the primate neocortex.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 767905740 301 CRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSL 353
Cdd:cd13766    1 CSRKPLHVNFKDLGWDDWIIAPLDYEAYHCEGVCDFPLRSHLEPTNHAIIQTL 53

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 3 (BMP-3), growth/differentiation factor 10 (GDF10) and similar proteins; The family includes BMP-3 (also known as BMP-3A or osteogenin) and GDF10 (also known as BMP-3B). BMP-3 negatively regulates bone density. It antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification. GDF10 is a growth factor involved in osteogenesis and adipogenesis.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 767905740 301 CRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSL 353
Cdd:cd13763    1 CSRRPLTVDFADIGWSDWIISPKSFDAYYCAGSCPFPLTKELRPSNHATIQSI 53

transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 5 (GDF5) and similar proteins; GDF5, also termed bone morphogenetic protein 14 (BMP-14), or cartilage-derived morphogenetic protein 1 (CDMP-1), or lipopolysaccharide-associated protein 4 (LAP-4), or LPS-associated protein 4, or radotermin, is a growth factor involved in bone and cartilage formation.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 767905740 301 CRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSL 353
Cdd:cd19399    2 CSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTL 54

transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 9 (GDF-9), growth/differentiation factor 9B (GDF-9B) and similar proteins; The family includes GDF-9B (also known as BMP15) and GDF9. GDF-9B acts as oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth. GDF-9 is required for ovarian folliculogenesis. It promotes primordial follicle development and stimulates granulosa cell proliferation.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 767905740 301 CRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSL 353
Cdd:cd13762    3 CRRHRLRVRFRDLKWNGWIIAPTRYTANYCKGTCPRVLGQDLNPTNHAIVQNI 55

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 10 (BMP-10) and similar proteins; BMP-10 is required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. It inhibits endothelial cell migration and growth. It may reduce cell migration and cell matrix adhesion in breast cancer cell lines.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 767905740 301 CRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSL 353
Cdd:cd19401    3 CKRSPLYVDFKEIGWDSWIIAPTGYEAYECRGVCYYPLTEHVTPTKHAIVQTL 55

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 3 (BMP-3) and similar proteins; BMP-3, also termed BMP-3A, or osteogenin, negatively regulates bone density. It antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 767905740 301 CRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSL 353
Cdd:cd19393    8 CARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQSI 60

transforming growth factor beta (TGF-beta) like domain found in mammalian growth/differentiation factor 15 (GDF-15) and similar proteins; GDF-15, also termed macrophage inhibitory cytokine 1 (MIC-1), or NSAID-activated gene 1 protein (NAG-1), or NSAID-regulated gene 1 protein (NRG-1), or placental TGF-beta, or placental bone morphogenetic protein, or prostate differentiation factor, regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 767905740 301 CRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSfplDSCMNATNHAILQSL 353
Cdd:cd19376    3 CCRFSLRVSFKEIGWADWVLAPESYNAYYCDGSCP---HNYKPANMHAQIKSR 52

transforming growth factor beta (TGF-beta) like domain found in inhibin alpha chain (INHA), beta chain (INHB) and similar proteins; INHA is a component of inhibins (inhibin A or inhibin B) that inhibit the secretion of follitropin by the pituitary gland. INHB includes inhibin beta A chain (INHBA), B chain (INHBB), C chain (INHBC), and E chain (INHBE). INHBA, also termed activin beta-A chain, or erythroid differentiation protein (EDF), is a component of inhibin A, activin A, or activin AB. Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. INHBB, also termed activin beta-B chain, is a component of inhibin B, activin A, or activin AB. Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. INHBC, also termed activin beta-C chain, might play important roles in carcinogenesis. It may function as a negative regulator of liver growth. INHBE, also termed activin beta-E chain, is a possible insulin resistance-associated hepatokine with hepatic gene expression that positively correlated with insulin resistance and body mass index in humans. It also acts as a possible new marker for drug-induced endoplasmic reticulum stress.

                         10        20        30
                 ....*....|....*....|....*....|....
gi 767905740 301 CRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGEC 334
Cdd:cd19377    1 CCRVALFVSFEELGWNRWIIAPPGFNFHFCHGGC 34

transforming growth factor beta (TGF-beta) like domain found in inhibin beta A chain (INHBA) and similar proteins; INHBA, also termed activin beta-A chain, or erythroid differentiation protein (EDF), is a component of inhibin A, activin A, or activin AB. Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland.

                         10        20        30
                 ....*....|....*....|....*....|....*
gi 767905740 300 VCRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGEC 334
Cdd:cd19404    2 ICCKKQFYVSFKDIGWSDWIIAPSGYHANYCEGEC 36

transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 8 (GDF8) and similar proteins; GDF8, also termed myostatin, acts specifically as a negative regulator of skeletal muscle growth.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 767905740 291 DVHGSHGRqvCRRHELYVSFQDLGWlDWVIAPQGYSAYYCEGECSF 336
Cdd:cd19388    6 DEHSTESR--CCRYPLTVDFEAFGW-DWIIAPKRYKANYCSGECEF 48

transforming growth factor beta (TGF-beta) like domain found in transforming growth factor beta-1 (TGF-beta-1), beta-2 (TGF-beta-2), beta-3 (TGF-beta-3) and similar proteins; The family includes TGF-beta-1, TGF-beta-2 and TGF-beta-3, which are polypeptide members of the transforming growth factor beta superfamily of cytokines. TGF-beta-1 is a secreted protein that performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation, and apoptosis. TGF-beta-2 is a secreted protein that performs many cellular functions and has a vital role during embryonic development. It can suppress the effects of interleukin-2 dependent T-cell growth. TGF-beta-3 is involved in embryogenesis and cell differentiation. It regulates molecules involved in cellular adhesion and extracellular matrix (ECM) formation during the process of palate development.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 767905740 301 CRRHELYVSFQ-DLGWlDWVIAPQGYSAYYCEGECSFPLDSCMNAT 345
Cdd:cd13753    1 CCLRPLYINFRrDLGW-KWIHEPKGFNANYCAGACPYLWSADTQHS 45

transforming growth factor beta (TGF-beta) like domain found in Drosophila melanogaster maverick and similar proteins; Maverick, also termed MAV, is a novel member of the TGF-beta superfamily in Drosophila. It's a bone morphogenetic protein (BMP)/TGF-beta related ligand.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767905740 301 CRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECsfPLDScmN-ATNHAILQSL 353
Cdd:cd13755    4 CCRHSLKVDFKKLPGFEWIIQPKEFDAGYCKGRC--PPRY--NyANNHALIQSL 53

transforming growth factor beta (TGF-beta) like domain found in Caenorhabditis elegans Dauer larva development regulatory growth factor DAF-7 and similar proteins; DAF-7, also termed abnormal dauer formation protein 7, may act as a negative regulator of dauer larva development by transducing chemosensory information from ASI neurons. It is involved in sensitivity to CO2 levels.

                         10        20        30
                 ....*....|....*....|....*....|....*
gi 767905740 301 CRRHELYVSFQDLGWlDWVIAPQGYSAYYCEGECS 335
Cdd:cd19378    3 CCLYDLTIDFEEIGW-NFIIAPKKYNANMCRGDCK 36

transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 11 (GDF11) and similar proteins; GDF11, also termed bone morphogenetic protein 11 (BMP-11), is a secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 767905740 287 GIFDDVHGSHGRqvCRRHELYVSFQDLGWlDWVIAPQGYSAYYCEGECSF 336
Cdd:cd19389    3 GLDCDEHSTESR--CCRYPLTVDFEAFGW-DWIIAPKRYKANYCSGQCEY 49

transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 9 (GDF-9) and similar proteins; GDF-9 is required for ovarian folliculogenesis. It promotes primordial follicle development and stimulates granulosa cell proliferation.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 767905740 301 CRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSL 353
Cdd:cd19403    5 CELHDFRLSFSQLKWDHWIIAPHRYNPRYCKGSCPRAVGHRYGSPVHTMVQNI 57

transforming growth factor beta (TGF-beta) like domain found in transforming growth factor beta-2 (TGF-beta-2) and similar proteins; TGF-beta-2, also termed BSC-1 cell growth inhibitor, or cetermin, or glioblastoma-derived T-cell suppressor factor (G-TSF), or polyergin, is a polypeptide member of the transforming growth factor beta superfamily of cytokines. It is a secreted protein that performs many cellular functions and has a vital role during embryonic development. It can suppress the effects of interleukin-2 dependent T-cell growth.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767905740 301 CRRHELYVSFQ-DLGWlDWVIAPQGYSAYYCEGECSFPLDScmnATNHAILQSL 353
Cdd:cd19385    1 CCLRPLYIDFKrDLGW-KWIHEPKGYNANFCAGACPYLWSS---DTQHSRVLSL 50

transforming growth factor beta (TGF-beta) like domain found in Danio rerio gonadal somatic cell derived factor (GSDF) and similar proteins; GSDF is a new member of transforming growth factor beta (TGF-beta) superfamily. It is a teleost- and gonad-specific growth factor that controls sex determination in some fish and plays an important role in mediating germ cell/soma signaling.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767905740 301 CRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGecsfpldsCMNATNHAILQSLE 354
Cdd:cd19379    3 CCQETSEIFFKDLGWENWVIYPESFTYVQCVG--------CNAGRNSSESQCRQ 48