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putative metallophosphoesterase At3g03305 isoform X1 [Oryza sativa Japonica Group]
metallophosphoesterase family protein( domain architecture ID 46112)
metallophosphoesterase family protein may contain an active site consisting of two metal ions (usually manganese, iron, or zinc)
List of domain hits
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Name | Accession | Description | Interval | E-value | ||||
MPP_superfamily super family | cl13995 | metallophosphatase superfamily, metallophosphatase domain; Metallophosphatases (MPPs), also ... |
47-262 | 1.39e-37 | ||||
metallophosphatase superfamily, metallophosphatase domain; Metallophosphatases (MPPs), also known as metallophosphoesterases, phosphodiesterases (PDEs), binuclear metallophosphoesterases, and dimetal-containing phosphoesterases (DMPs), represent a diverse superfamily of enzymes with a conserved domain containing an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. This superfamily includes: the phosphoprotein phosphatases (PPPs), Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination. The actual alignment was detected with superfamily member cd07401: Pssm-ID: 472684 [Multi-domain] Cd Length: 254 Bit Score: 140.96 E-value: 1.39e-37
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Name | Accession | Description | Interval | E-value | ||||
MPP_TMEM62_N | cd07401 | Homo sapiens TMEM62, N-terminal metallophosphatase domain; TMEM62 (transmembrane protein 62) ... |
47-262 | 1.39e-37 | ||||
Homo sapiens TMEM62, N-terminal metallophosphatase domain; TMEM62 (transmembrane protein 62) is an uncharacterized Homo sapiens transmembrane protein with an N-terminal metallophosphatase domain. TMEM62 belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination. Pssm-ID: 277346 [Multi-domain] Cd Length: 254 Bit Score: 140.96 E-value: 1.39e-37
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CpdA | COG1409 | 3',5'-cyclic AMP phosphodiesterase CpdA [Signal transduction mechanisms]; |
48-262 | 1.30e-14 | ||||
3',5'-cyclic AMP phosphodiesterase CpdA [Signal transduction mechanisms]; Pssm-ID: 441019 [Multi-domain] Cd Length: 234 Bit Score: 73.96 E-value: 1.30e-14
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Metallophos | pfam00149 | Calcineurin-like phosphoesterase; This family includes a diverse range of phosphoesterases, ... |
48-150 | 2.00e-05 | ||||
Calcineurin-like phosphoesterase; This family includes a diverse range of phosphoesterases, including protein phosphoserine phosphatases, nucleotidases, sphingomyelin phosphodiesterases and 2'-3' cAMP phosphodiesterases as well as nucleases such as bacterial SbcD or yeast MRE11. The most conserved regions in this superfamily centre around the metal chelating residues. Pssm-ID: 459691 [Multi-domain] Cd Length: 114 Bit Score: 44.13 E-value: 2.00e-05
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Name | Accession | Description | Interval | E-value | ||||
MPP_TMEM62_N | cd07401 | Homo sapiens TMEM62, N-terminal metallophosphatase domain; TMEM62 (transmembrane protein 62) ... |
47-262 | 1.39e-37 | ||||
Homo sapiens TMEM62, N-terminal metallophosphatase domain; TMEM62 (transmembrane protein 62) is an uncharacterized Homo sapiens transmembrane protein with an N-terminal metallophosphatase domain. TMEM62 belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination. Pssm-ID: 277346 [Multi-domain] Cd Length: 254 Bit Score: 140.96 E-value: 1.39e-37
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CpdA | COG1409 | 3',5'-cyclic AMP phosphodiesterase CpdA [Signal transduction mechanisms]; |
48-262 | 1.30e-14 | ||||
3',5'-cyclic AMP phosphodiesterase CpdA [Signal transduction mechanisms]; Pssm-ID: 441019 [Multi-domain] Cd Length: 234 Bit Score: 73.96 E-value: 1.30e-14
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MPP_1 | cd07400 | Uncharacterized subfamily, metallophosphatase domain; Uncharacterized subfamily of the MPP ... |
49-136 | 2.95e-06 | ||||
Uncharacterized subfamily, metallophosphatase domain; Uncharacterized subfamily of the MPP superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination. Pssm-ID: 277345 [Multi-domain] Cd Length: 138 Bit Score: 47.29 E-value: 2.95e-06
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Metallophos | pfam00149 | Calcineurin-like phosphoesterase; This family includes a diverse range of phosphoesterases, ... |
48-150 | 2.00e-05 | ||||
Calcineurin-like phosphoesterase; This family includes a diverse range of phosphoesterases, including protein phosphoserine phosphatases, nucleotidases, sphingomyelin phosphodiesterases and 2'-3' cAMP phosphodiesterases as well as nucleases such as bacterial SbcD or yeast MRE11. The most conserved regions in this superfamily centre around the metal chelating residues. Pssm-ID: 459691 [Multi-domain] Cd Length: 114 Bit Score: 44.13 E-value: 2.00e-05
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YaeI | COG1408 | Predicted phosphohydrolase, MPP superfamily [General function prediction only]; |
48-139 | 1.52e-04 | ||||
Predicted phosphohydrolase, MPP superfamily [General function prediction only]; Pssm-ID: 441018 [Multi-domain] Cd Length: 268 Bit Score: 44.02 E-value: 1.52e-04
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COG1407 | COG1407 | Metallophosphoesterase superfamily enzyme [General function prediction only]; |
51-139 | 9.94e-03 | ||||
Metallophosphoesterase superfamily enzyme [General function prediction only]; Pssm-ID: 441017 Cd Length: 224 Bit Score: 38.32 E-value: 9.94e-03
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Blast search parameters | ||||
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