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Conserved domains on  [gi|1002224842|ref|XP_015645700|]
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peroxisomal membrane protein PEX14 isoform X1 [Oryza sativa Japonica Group]

Protein Classification

peroxisomal membrane protein PEX14( domain architecture ID 10520091)

peroxisomal membrane protein PEX14 is a receptor-docking protein which is located on the cytoplasmic surface of the peroxisomal membrane and binds peroxisomal targeting signal (PTS) receptors carrying proteins bound for the peroxisomal matrix.

CATH:  1.10.10.10
Gene Ontology:  GO:0005778|GO:0016560|GO:0005515|GO:0008320
SCOP:  4005026
TCDB:  3.A.20

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pex14_N pfam04695
Pex14 N-terminal domain; Family of peroxisomal membrane anchor proteins which bind the PTS1 ...
 31-76 3.08e-13

Pex14 N-terminal domain; Family of peroxisomal membrane anchor proteins which bind the PTS1 (peroxisomal targeting signal) receptor and are required for the import of PTS1-containing proteins into peroxisomes. Loss of functional Pex14p results in defects in both the PTS1 and PTS2-dependent import pathways. Deletion analysis of this conserved region implicates it in selective peroxisome degradation. In the majority of members this region is situated at the N-terminus of the protein.


:

Pssm-ID: 461395 [Multi-domain]  Cd Length: 46  Bit Score: 63.73  E-value: 3.08e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1002224842  31 MREDYIQNAVNFLGHPKVKGSPVFYRRSFLEKKGLTKEEIDEAFRR 76
Cdd:pfam04695   1 DREDLLEQARKFLQDPSVRNAPREKKVAFLKSKGLSDEEIEELLGE 46
PRK10263 super family cl35903
DNA translocase FtsK; Provisional
 294-424 4.69e-03

DNA translocase FtsK; Provisional


The actual alignment was detected with superfamily member PRK10263:

Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 39.68  E-value: 4.69e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224842  294 PFMPVPGEPSPGAFPARSYVEQQRMQRP------------GYGFQPQMS------NDRWNPGSPLTNYHGAPPYQQYHHG 355
Cdd:PRK10263   339 PVTQTPPVASVDVPPAQPTVAWQPVPGPqtgepviapapeGYPQQSQYAqpavqyNEPLQQPVQPQQPYYAPAAEQPAQQ 418

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1002224842  356 STNAIDEAPAPAPVPAPAPPAESPFQRRWVPPQPPGVVMPEAVAAIRQPRQQVAAASRPSESAAATEQP 424
Cdd:PRK10263   419 PYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQSTFAPQSTYQTEQTYQQPAAQEPLYQQPQPVEQQ 487
 
Name Accession Description Interval E-value
Pex14_N pfam04695
Pex14 N-terminal domain; Family of peroxisomal membrane anchor proteins which bind the PTS1 ...
 31-76 3.08e-13

Pex14 N-terminal domain; Family of peroxisomal membrane anchor proteins which bind the PTS1 (peroxisomal targeting signal) receptor and are required for the import of PTS1-containing proteins into peroxisomes. Loss of functional Pex14p results in defects in both the PTS1 and PTS2-dependent import pathways. Deletion analysis of this conserved region implicates it in selective peroxisome degradation. In the majority of members this region is situated at the N-terminus of the protein.


Pssm-ID: 461395 [Multi-domain]  Cd Length: 46  Bit Score: 63.73  E-value: 3.08e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1002224842  31 MREDYIQNAVNFLGHPKVKGSPVFYRRSFLEKKGLTKEEIDEAFRR 76
Cdd:pfam04695   1 DREDLLEQARKFLQDPSVRNAPREKKVAFLKSKGLSDEEIEELLGE 46
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 294-424 4.69e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 39.68  E-value: 4.69e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224842  294 PFMPVPGEPSPGAFPARSYVEQQRMQRP------------GYGFQPQMS------NDRWNPGSPLTNYHGAPPYQQYHHG 355
Cdd:PRK10263   339 PVTQTPPVASVDVPPAQPTVAWQPVPGPqtgepviapapeGYPQQSQYAqpavqyNEPLQQPVQPQQPYYAPAAEQPAQQ 418

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1002224842  356 STNAIDEAPAPAPVPAPAPPAESPFQRRWVPPQPPGVVMPEAVAAIRQPRQQVAAASRPSESAAATEQP 424
Cdd:PRK10263   419 PYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQSTFAPQSTYQTEQTYQQPAAQEPLYQQPQPVEQQ 487
 
Name Accession Description Interval E-value
Pex14_N pfam04695
Pex14 N-terminal domain; Family of peroxisomal membrane anchor proteins which bind the PTS1 ...
 31-76 3.08e-13

Pex14 N-terminal domain; Family of peroxisomal membrane anchor proteins which bind the PTS1 (peroxisomal targeting signal) receptor and are required for the import of PTS1-containing proteins into peroxisomes. Loss of functional Pex14p results in defects in both the PTS1 and PTS2-dependent import pathways. Deletion analysis of this conserved region implicates it in selective peroxisome degradation. In the majority of members this region is situated at the N-terminus of the protein.


Pssm-ID: 461395 [Multi-domain]  Cd Length: 46  Bit Score: 63.73  E-value: 3.08e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1002224842  31 MREDYIQNAVNFLGHPKVKGSPVFYRRSFLEKKGLTKEEIDEAFRR 76
Cdd:pfam04695   1 DREDLLEQARKFLQDPSVRNAPREKKVAFLKSKGLSDEEIEELLGE 46
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 294-424 4.69e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 39.68  E-value: 4.69e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002224842  294 PFMPVPGEPSPGAFPARSYVEQQRMQRP------------GYGFQPQMS------NDRWNPGSPLTNYHGAPPYQQYHHG 355
Cdd:PRK10263   339 PVTQTPPVASVDVPPAQPTVAWQPVPGPqtgepviapapeGYPQQSQYAqpavqyNEPLQQPVQPQQPYYAPAAEQPAQQ 418

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1002224842  356 STNAIDEAPAPAPVPAPAPPAESPFQRRWVPPQPPGVVMPEAVAAIRQPRQQVAAASRPSESAAATEQP 424
Cdd:PRK10263   419 PYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQSTFAPQSTYQTEQTYQQPAAQEPLYQQPQPVEQQ 487
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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