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Conserved domains on  [gi|2756276124|ref|XP_015645737|]
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protein ACCELERATED CELL DEATH 6 [Oryza sativa Japonica Group]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 12380331)

ankyrin repeat (ANK) domain-containing protein may be involved in mediating protein-protein interactions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PGG pfam13962
Domain of unknown function; The PGG domain is named for the highly conserved sequence motif ...
 462-568 5.95e-24

Domain of unknown function; The PGG domain is named for the highly conserved sequence motif found at the startt of the domain. The function is not known.


:

Pssm-ID: 433609  Cd Length: 114  Bit Score: 96.85  E-value: 5.95e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756276124 462 TSTGTVASVLIATVTFAAALTVPGGYVADD-HPNAGTAASAGRFAFRAFAVSDTMAFLCSIVGTCLLVVGEAREVRPSRG 540
Cdd:pfam13962   8 RNTLLLVATLIATVTFAAGFTPPGGYWQDDdGPHAGKPILAKNPAFKAFVISNAIAFFASLVAVVLLLSIVSDFLRSLPR 87

                          90       100
                  ....*....|....*....|....*...
gi 2756276124 541 RLRAyqgSAWALVTAGAqFMVAAFAFGL 568
Cdd:pfam13962  88 KLRI---GLKLLWVALL-SMLVAFAAGS 111
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
168-426 1.83e-19

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 89.24  E-value: 1.83e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756276124 168 LMAEAPELASVANDGGVSPLYLAATVGSVDIVRALLHPLPDGTPSPASAAGPDGRTALHSAATTSKEIAREILDwkpEGR 247
Cdd:COG0666     1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLL---AAG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756276124 248 TLLTKADSSGRTPLHFAISSqiERFDVFQLFLDAEPSLALVcDIQGSFPLHVAAVMGSVRIVVELIQKCPNNynDLVDDR 327
Cdd:COG0666    78 ADINAKDDGGNTLLHAAARN--GDLEIVKLLLEAGADVNAR-DKDGETPLHLAAYNGNLEIVKLLLEAGADV--NAQDND 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756276124 328 GRNFLHCAVEHNKESIVRYICRddrFGILMNAMDNEGNTPLHLAAEYGHPRMVSLLLETmSVDVAITNRDGLTAADLAYR 407
Cdd:COG0666   153 GNTPLHLAAANGNLEIVKLLLE---AGADVNARDNDGETPLHLAAENGHLEIVKLLLEA-GADVNAKDNDGKTALDLAAE 228

                         250
                  ....*....|....*....
gi 2756276124 408 HLQPGLHYFLNPRAVVKNL 426
Cdd:COG0666   229 NGNLEIVKLLLEAGADLNA 247
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
38-287 3.47e-16

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 79.61  E-value: 3.47e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756276124  38 GHSLSQVAIRVDDDDDGRAPAGASRLLGVTTGNGNTALHVAATRGHAALAALVCAtAPALAATRNRFLDTPLHCAAKSGH 117
Cdd:COG0666    54 GALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLE-AGADVNARDKDGETPLHLAAYNGN 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756276124 118 RDVAACLLsemlrAGGAASAalplrrATNCLGATALHEAVRNGHAGVVALLMaEAPELASVANDGGVSPLYLAATVGSVD 197
Cdd:COG0666   133 LEIVKLLL-----EAGADVN------AQDNDGNTPLHLAAANGNLEIVKLLL-EAGADVNARDNDGETPLHLAAENGHLE 200

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756276124 198 IVRALLhplpdgtpspasAAGPD-------GRTALHSAAttsKEIAREILDWKPEGRTLLTKADSSGRTPLHFAISSQIE 270
Cdd:COG0666   201 IVKLLL------------EAGADvnakdndGKTALDLAA---ENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAA 265

                         250
                  ....*....|....*..
gi 2756276124 271 RFDVFQLFLDAEPSLAL 287
Cdd:COG0666   266 LIVKLLLLALLLLAAAL 282
 
Name Accession Description Interval E-value
PGG pfam13962
Domain of unknown function; The PGG domain is named for the highly conserved sequence motif ...
 462-568 5.95e-24

Domain of unknown function; The PGG domain is named for the highly conserved sequence motif found at the startt of the domain. The function is not known.


Pssm-ID: 433609  Cd Length: 114  Bit Score: 96.85  E-value: 5.95e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756276124 462 TSTGTVASVLIATVTFAAALTVPGGYVADD-HPNAGTAASAGRFAFRAFAVSDTMAFLCSIVGTCLLVVGEAREVRPSRG 540
Cdd:pfam13962   8 RNTLLLVATLIATVTFAAGFTPPGGYWQDDdGPHAGKPILAKNPAFKAFVISNAIAFFASLVAVVLLLSIVSDFLRSLPR 87

                          90       100
                  ....*....|....*....|....*...
gi 2756276124 541 RLRAyqgSAWALVTAGAqFMVAAFAFGL 568
Cdd:pfam13962  88 KLRI---GLKLLWVALL-SMLVAFAAGS 111
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
168-426 1.83e-19

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 89.24  E-value: 1.83e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756276124 168 LMAEAPELASVANDGGVSPLYLAATVGSVDIVRALLHPLPDGTPSPASAAGPDGRTALHSAATTSKEIAREILDwkpEGR 247
Cdd:COG0666     1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLL---AAG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756276124 248 TLLTKADSSGRTPLHFAISSqiERFDVFQLFLDAEPSLALVcDIQGSFPLHVAAVMGSVRIVVELIQKCPNNynDLVDDR 327
Cdd:COG0666    78 ADINAKDDGGNTLLHAAARN--GDLEIVKLLLEAGADVNAR-DKDGETPLHLAAYNGNLEIVKLLLEAGADV--NAQDND 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756276124 328 GRNFLHCAVEHNKESIVRYICRddrFGILMNAMDNEGNTPLHLAAEYGHPRMVSLLLETmSVDVAITNRDGLTAADLAYR 407
Cdd:COG0666   153 GNTPLHLAAANGNLEIVKLLLE---AGADVNARDNDGETPLHLAAENGHLEIVKLLLEA-GADVNAKDNDGKTALDLAAE 228

                         250
                  ....*....|....*....
gi 2756276124 408 HLQPGLHYFLNPRAVVKNL 426
Cdd:COG0666   229 NGNLEIVKLLLEAGADLNA 247
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
38-287 3.47e-16

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 79.61  E-value: 3.47e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756276124  38 GHSLSQVAIRVDDDDDGRAPAGASRLLGVTTGNGNTALHVAATRGHAALAALVCAtAPALAATRNRFLDTPLHCAAKSGH 117
Cdd:COG0666    54 GALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLE-AGADVNARDKDGETPLHLAAYNGN 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756276124 118 RDVAACLLsemlrAGGAASAalplrrATNCLGATALHEAVRNGHAGVVALLMaEAPELASVANDGGVSPLYLAATVGSVD 197
Cdd:COG0666   133 LEIVKLLL-----EAGADVN------AQDNDGNTPLHLAAANGNLEIVKLLL-EAGADVNARDNDGETPLHLAAENGHLE 200

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756276124 198 IVRALLhplpdgtpspasAAGPD-------GRTALHSAAttsKEIAREILDWKPEGRTLLTKADSSGRTPLHFAISSQIE 270
Cdd:COG0666   201 IVKLLL------------EAGADvnakdndGKTALDLAA---ENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAA 265

                         250
                  ....*....|....*..
gi 2756276124 271 RFDVFQLFLDAEPSLAL 287
Cdd:COG0666   266 LIVKLLLLALLLLAAAL 282
Ank_2 pfam12796
Ankyrin repeats (3 copies);
297-385 6.21e-13

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 64.75  E-value: 6.21e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756276124 297 LHVAAVMGSVRIVVELIQKCPNNynDLVDDRGRNFLHCAVEHNKESIVRYICRDDRFGilmnaMDNEGNTPLHLAAEYGH 376
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADA--NLQDKNGRTALHLAAKNGHLEIVKLLLEHADVN-----LKDNGRTALHYAARSGH 73


                  ....*....
gi 2756276124 377 PRMVSLLLE 385
Cdd:pfam12796  74 LEIVKLLLE 82
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 141-450 3.00e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 69.22  E-value: 3.00e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756276124 141 LRRATNCLG------ATALHEAVRNGHAGVVALLMAEAPELASVaNDGGVSPLYLAATVGSVDIVRALLHPLPDGTPSPA 214
Cdd:PHA02874   21 IKNKGNCINisvdetTTPLIDAIRSGDAKIVELFIKHGADINHI-NTKIPHPLLTAIKIGAHDIIKLLIDNGVDTSILPI 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756276124 215 saagPDgrtalhsaatTSKEIAREILDwkpEGRTLLTKaDSSGRTPLHFAISSQieRFDVFQLFLDAEPSLAlVCDIQGS 294
Cdd:PHA02874  100 ----PC----------IEKDMIKTILD---CGIDVNIK-DAELKTFLHYAIKKG--DLESIKMLFEYGADVN-IEDDNGC 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756276124 295 FPLHVAAVMGSVRIVVELIQKcpNNYNDLVDDRGRNFLHCAVEHNKESIVRYICrdDRFGILMNAMDNeGNTPLHLAAEY 374
Cdd:PHA02874  159 YPIHIAIKHNFFDIIKLLLEK--GAYANVKDNNGESPLHNAAEYGDYACIKLLI--DHGNHIMNKCKN-GFTPLHNAIIH 233

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2756276124 375 GHpRMVSLLLETMSVDVaiTNRDGLTAadlayrhlqpgLHYFLNP---RAVVKNLFYcTRAPVTLEGDHARTGIPSAME 450
Cdd:PHA02874  234 NR-SAIELLINNASIND--QDIDGSTP-----------LHHAINPpcdIDIIDILLY-HKADISIKDNKGENPIDTAFK 297
Ank_2 pfam12796
Ankyrin repeats (3 copies);
109-208 8.12e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 58.97  E-value: 8.12e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756276124 109 LHCAAKSGHRDVAACLLSEMLRAGgaasaalplrrATNCLGATALHEAVRNGHAGVVALLMAEApelASVANDGGVSPLY 188
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADAN-----------LQDKNGRTALHLAAKNGHLEIVKLLLEHA---DVNLKDNGRTALH 66

                          90       100
                  ....*....|....*....|
gi 2756276124 189 LAATVGSVDIVRALLHPLPD 208
Cdd:pfam12796  67 YAARSGHLEIVKLLLEKGAD 86
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 103-315 4.57e-09

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 59.64  E-value: 4.57e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756276124 103 RFLDTPLHCAAKSGhrDVAAclLSEMLRAggaaSAALPLRRATncLGATALHEAVRNGHAGVVALLMAEAPELASVANDG 182
Cdd:cd22192    15 RISESPLLLAAKEN--DVQA--IKKLLKC----PSCDLFQRGA--LGETALHVAALYDNLEAAVVLMEAAPELVNEPMTS 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756276124 183 ----GVSPLYLAATVGSVDIVRALLHPLPD-GTPSPASAAGPDGRTAL-----H----SAATTSKEIAREILDwkpegRT 248
Cdd:cd22192    85 dlyqGETALHIAVVNQNLNLVRELIARGADvVSPRATGTFFRPGPKNLiyygeHplsfAACVGNEEIVRLLIE-----HG 159

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2756276124 249 LLTKA-DSSGRTPLHFAISSQIERF--DVFQLFLDAEP-----SLALVCDIQGSFPLHVAAVMGSVRIVVELIQK 315
Cdd:cd22192   160 ADIRAqDSLGNTVLHILVLQPNKTFacQMYDLILSYDKeddlqPLDLVPNNQGLTPFKLAAKEGNIVMFQHLVQK 234
PHA03095 PHA03095
ankyrin-like protein; Provisional
 71-180 3.09e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 43.86  E-value: 3.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756276124  71 GNTALHVAATRGHAALAALVcataPALAA-----TRNRFLDTPLHCAAKSGHRDVAACLlsemLRAGGAASAalplrrAT 145
Cdd:PHA03095  222 GNTPLHSMATGSSCKRSLVL----PLLIAgisinARNRYGQTPLHYAAVFNNPRACRRL----IALGADINA------VS 287

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2756276124 146 NClGATALHEAVRNGHAGVVALLMAEAPELASVAN 180
Cdd:PHA03095  288 SD-GNTPLSLMVRNNNGRAVRAALAKNPSAETVAA 321
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 363-385 8.22e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.18  E-value: 8.22e-04
                           10        20
                   ....*....|....*....|...
gi 2756276124  363 EGNTPLHLAAEYGHPRMVSLLLE 385
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLD 23
 
Name Accession Description Interval E-value
PGG pfam13962
Domain of unknown function; The PGG domain is named for the highly conserved sequence motif ...
 462-568 5.95e-24

Domain of unknown function; The PGG domain is named for the highly conserved sequence motif found at the startt of the domain. The function is not known.


Pssm-ID: 433609  Cd Length: 114  Bit Score: 96.85  E-value: 5.95e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756276124 462 TSTGTVASVLIATVTFAAALTVPGGYVADD-HPNAGTAASAGRFAFRAFAVSDTMAFLCSIVGTCLLVVGEAREVRPSRG 540
Cdd:pfam13962   8 RNTLLLVATLIATVTFAAGFTPPGGYWQDDdGPHAGKPILAKNPAFKAFVISNAIAFFASLVAVVLLLSIVSDFLRSLPR 87

                          90       100
                  ....*....|....*....|....*...
gi 2756276124 541 RLRAyqgSAWALVTAGAqFMVAAFAFGL 568
Cdd:pfam13962  88 KLRI---GLKLLWVALL-SMLVAFAAGS 111
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
168-426 1.83e-19

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 89.24  E-value: 1.83e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756276124 168 LMAEAPELASVANDGGVSPLYLAATVGSVDIVRALLHPLPDGTPSPASAAGPDGRTALHSAATTSKEIAREILDwkpEGR 247
Cdd:COG0666     1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLL---AAG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756276124 248 TLLTKADSSGRTPLHFAISSqiERFDVFQLFLDAEPSLALVcDIQGSFPLHVAAVMGSVRIVVELIQKCPNNynDLVDDR 327
Cdd:COG0666    78 ADINAKDDGGNTLLHAAARN--GDLEIVKLLLEAGADVNAR-DKDGETPLHLAAYNGNLEIVKLLLEAGADV--NAQDND 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756276124 328 GRNFLHCAVEHNKESIVRYICRddrFGILMNAMDNEGNTPLHLAAEYGHPRMVSLLLETmSVDVAITNRDGLTAADLAYR 407
Cdd:COG0666   153 GNTPLHLAAANGNLEIVKLLLE---AGADVNARDNDGETPLHLAAENGHLEIVKLLLEA-GADVNAKDNDGKTALDLAAE 228

                         250
                  ....*....|....*....
gi 2756276124 408 HLQPGLHYFLNPRAVVKNL 426
Cdd:COG0666   229 NGNLEIVKLLLEAGADLNA 247
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
150-426 1.27e-18

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 86.93  E-value: 1.27e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756276124 150 ATALHEAVRNGHAGVVALLMAEAPELASVANDGGVSPLYLAATVGSVDIVRALLHPLPDgtpspASAAGPDGRTALHSAA 229
Cdd:COG0666    21 LALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGAD-----INAKDDGGNTLLHAAA 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756276124 230 TT-SKEIAREILDWKPEgrtlLTKADSSGRTPLHFAISSqiERFDVFQLFLDAEPSLALVcDIQGSFPLHVAAVMGSVRI 308
Cdd:COG0666    96 RNgDLEIVKLLLEAGAD----VNARDKDGETPLHLAAYN--GNLEIVKLLLEAGADVNAQ-DNDGNTPLHLAAANGNLEI 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756276124 309 VVELIQKCPNNynDLVDDRGRNFLHCAVEHNKESIVRYICRddrFGILMNAMDNEGNTPLHLAAEYGHPRMVSLLLETMS 388
Cdd:COG0666   169 VKLLLEAGADV--NARDNDGETPLHLAAENGHLEIVKLLLE---AGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGA 243

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 2756276124 389 vDVAITNRDGLTAADLAYRHLQPGLHYFLNPRAVVKNL 426
Cdd:COG0666   244 -DLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAA 280
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
70-401 1.98e-17

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 83.46  E-value: 1.98e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756276124  70 NGNTALHVAATRGHAALAALVCATAPALAATRNRFLDTPLHCAAKSGHRDVAACLLsemlraggaasAALPLRRATNCLG 149
Cdd:COG0666    19 LLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLL-----------AAGADINAKDDGG 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756276124 150 ATALHEAVRNGHAGVVALLMAEAPELASVANDGGvSPLYLAATVGSVDIVRALLhplpdgtpspasAAGPDgrtalhsaa 229
Cdd:COG0666    88 NTLLHAAARNGDLEIVKLLLEAGADVNARDKDGE-TPLHLAAYNGNLEIVKLLL------------EAGAD--------- 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756276124 230 ttskeiareildwkpegrtlLTKADSSGRTPLHFAISSQieRFDVFQLFLDAEPSLALVcDIQGSFPLHVAAVMGSVRIV 309
Cdd:COG0666   146 --------------------VNAQDNDGNTPLHLAAANG--NLEIVKLLLEAGADVNAR-DNDGETPLHLAAENGHLEIV 202

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756276124 310 VELIQKCPNnyNDLVDDRGRNFLHCAVEHNKESIVRYIcrdDRFGILMNAMDNEGNTPLHLAAEYGHPRMVSLLLETMSV 389
Cdd:COG0666   203 KLLLEAGAD--VNAKDNDGKTALDLAAENGNLEIVKLL---LEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLL 277

                         330
                  ....*....|..
gi 2756276124 390 DVAITNRDGLTA 401
Cdd:COG0666   278 LAAALLDLLTLL 289
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
38-287 3.47e-16

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 79.61  E-value: 3.47e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756276124  38 GHSLSQVAIRVDDDDDGRAPAGASRLLGVTTGNGNTALHVAATRGHAALAALVCAtAPALAATRNRFLDTPLHCAAKSGH 117
Cdd:COG0666    54 GALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLE-AGADVNARDKDGETPLHLAAYNGN 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756276124 118 RDVAACLLsemlrAGGAASAalplrrATNCLGATALHEAVRNGHAGVVALLMaEAPELASVANDGGVSPLYLAATVGSVD 197
Cdd:COG0666   133 LEIVKLLL-----EAGADVN------AQDNDGNTPLHLAAANGNLEIVKLLL-EAGADVNARDNDGETPLHLAAENGHLE 200

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756276124 198 IVRALLhplpdgtpspasAAGPD-------GRTALHSAAttsKEIAREILDWKPEGRTLLTKADSSGRTPLHFAISSQIE 270
Cdd:COG0666   201 IVKLLL------------EAGADvnakdndGKTALDLAA---ENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAA 265

                         250
                  ....*....|....*..
gi 2756276124 271 RFDVFQLFLDAEPSLAL 287
Cdd:COG0666   266 LIVKLLLLALLLLAAAL 282
Ank_2 pfam12796
Ankyrin repeats (3 copies);
297-385 6.21e-13

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 64.75  E-value: 6.21e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756276124 297 LHVAAVMGSVRIVVELIQKCPNNynDLVDDRGRNFLHCAVEHNKESIVRYICRDDRFGilmnaMDNEGNTPLHLAAEYGH 376
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADA--NLQDKNGRTALHLAAKNGHLEIVKLLLEHADVN-----LKDNGRTALHYAARSGH 73


                  ....*....
gi 2756276124 377 PRMVSLLLE 385
Cdd:pfam12796  74 LEIVKLLLE 82
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 141-450 3.00e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 69.22  E-value: 3.00e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756276124 141 LRRATNCLG------ATALHEAVRNGHAGVVALLMAEAPELASVaNDGGVSPLYLAATVGSVDIVRALLHPLPDGTPSPA 214
Cdd:PHA02874   21 IKNKGNCINisvdetTTPLIDAIRSGDAKIVELFIKHGADINHI-NTKIPHPLLTAIKIGAHDIIKLLIDNGVDTSILPI 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756276124 215 saagPDgrtalhsaatTSKEIAREILDwkpEGRTLLTKaDSSGRTPLHFAISSQieRFDVFQLFLDAEPSLAlVCDIQGS 294
Cdd:PHA02874  100 ----PC----------IEKDMIKTILD---CGIDVNIK-DAELKTFLHYAIKKG--DLESIKMLFEYGADVN-IEDDNGC 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756276124 295 FPLHVAAVMGSVRIVVELIQKcpNNYNDLVDDRGRNFLHCAVEHNKESIVRYICrdDRFGILMNAMDNeGNTPLHLAAEY 374
Cdd:PHA02874  159 YPIHIAIKHNFFDIIKLLLEK--GAYANVKDNNGESPLHNAAEYGDYACIKLLI--DHGNHIMNKCKN-GFTPLHNAIIH 233

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2756276124 375 GHpRMVSLLLETMSVDVaiTNRDGLTAadlayrhlqpgLHYFLNP---RAVVKNLFYcTRAPVTLEGDHARTGIPSAME 450
Cdd:PHA02874  234 NR-SAIELLINNASIND--QDIDGSTP-----------LHHAINPpcdIDIIDILLY-HKADISIKDNKGENPIDTAFK 297
Ank_2 pfam12796
Ankyrin repeats (3 copies);
109-208 8.12e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 58.97  E-value: 8.12e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756276124 109 LHCAAKSGHRDVAACLLSEMLRAGgaasaalplrrATNCLGATALHEAVRNGHAGVVALLMAEApelASVANDGGVSPLY 188
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADAN-----------LQDKNGRTALHLAAKNGHLEIVKLLLEHA---DVNLKDNGRTALH 66

                          90       100
                  ....*....|....*....|
gi 2756276124 189 LAATVGSVDIVRALLHPLPD 208
Cdd:pfam12796  67 YAARSGHLEIVKLLLEKGAD 86
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 103-315 4.57e-09

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 59.64  E-value: 4.57e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756276124 103 RFLDTPLHCAAKSGhrDVAAclLSEMLRAggaaSAALPLRRATncLGATALHEAVRNGHAGVVALLMAEAPELASVANDG 182
Cdd:cd22192    15 RISESPLLLAAKEN--DVQA--IKKLLKC----PSCDLFQRGA--LGETALHVAALYDNLEAAVVLMEAAPELVNEPMTS 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756276124 183 ----GVSPLYLAATVGSVDIVRALLHPLPD-GTPSPASAAGPDGRTAL-----H----SAATTSKEIAREILDwkpegRT 248
Cdd:cd22192    85 dlyqGETALHIAVVNQNLNLVRELIARGADvVSPRATGTFFRPGPKNLiyygeHplsfAACVGNEEIVRLLIE-----HG 159

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2756276124 249 LLTKA-DSSGRTPLHFAISSQIERF--DVFQLFLDAEP-----SLALVCDIQGSFPLHVAAVMGSVRIVVELIQK 315
Cdd:cd22192   160 ADIRAqDSLGNTVLHILVLQPNKTFacQMYDLILSYDKeddlqPLDLVPNNQGLTPFKLAAKEGNIVMFQHLVQK 234
Ank_2 pfam12796
Ankyrin repeats (3 copies);
332-405 8.27e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 53.20  E-value: 8.27e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2756276124 332 LHCAVEHNKESIVRYICRddrFGILMNAMDNEGNTPLHLAAEYGHPRMVSLLLETMSVDVaitNRDGLTAADLA 405
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLE---NGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNL---KDNGRTALHYA 68
Ank_2 pfam12796
Ankyrin repeats (3 copies);
75-175 8.86e-08

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 50.11  E-value: 8.86e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756276124  75 LHVAATRGHAALA-ALVcaTAPALAATRNRFLDTPLHCAAKSGHRDVAACLLSEMlraggaasaalplRRATNCLGATAL 153
Cdd:pfam12796   1 LHLAAKNGNLELVkLLL--ENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHA-------------DVNLKDNGRTAL 65

                          90       100
                  ....*....|....*....|..
gi 2756276124 154 HEAVRNGHAGVVALLMAEAPEL 175
Cdd:pfam12796  66 HYAARSGHLEIVKLLLEKGADI 87
Ank_2 pfam12796
Ankyrin repeats (3 copies);
187-280 9.96e-08

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 50.11  E-value: 9.96e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756276124 187 LYLAATVGSVDIVRALLHPLPDgtpspASAAGPDGRTALHSAATT-SKEIAREILDwkpegrTLLTKADSSGRTPLHFAI 265
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGAD-----ANLQDKNGRTALHLAAKNgHLEIVKLLLE------HADVNLKDNGRTALHYAA 69

                          90
                  ....*....|....*
gi 2756276124 266 SSQieRFDVFQLFLD 280
Cdd:pfam12796  70 RSG--HLEIVKLLLE 82
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 288-400 1.54e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 54.29  E-value: 1.54e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756276124 288 VCDIQGSFPLHVAAV--MGSVRIVVELIQkcpNNYN-DLVDDRGRNFLHCAVE--HNKESIVRY----------ICRDDR 352
Cdd:PHA03100  101 APDNNGITPLLYAISkkSNSYSIVEYLLD---NGANvNIKNSDGENLLHLYLEsnKIDLKILKLlidkgvdinaKNRVNY 177

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2756276124 353 F---GILMNAMDNEGNTPLHLAAEYGHPRMVSLLLEtMSVDVAITNRDGLT 400
Cdd:PHA03100  178 LlsyGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLD-LGANPNLVNKYGDT 227
PHA03095 PHA03095
ankyrin-like protein; Provisional
 162-408 2.33e-07

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 53.88  E-value: 2.33e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756276124 162 AGVVALLMAEApelASVANDG--GVSPL--YLAATVG-SVDIVRALLhplpdgtpspasAAGPD-------GRTALHSAA 229
Cdd:PHA03095   27 VEEVRRLLAAG---ADVNFRGeyGKTPLhlYLHYSSEkVKDIVRLLL------------EAGADvnapercGFTPLHLYL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756276124 230 TTSKEIarEILDwkpegrtLLTKA-------DSSGRTPLHFAISSQIERFDVFQLFLDAEPSLAlVCDIQGSFPLHVaaV 302
Cdd:PHA03095   92 YNATTL--DVIK-------LLIKAgadvnakDKVGRTPLHVYLSGFNINPKVIRLLLRKGADVN-ALDLYGMTPLAV--L 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756276124 303 MGSVRIVVE----LIQKCPNNYNdlVDDRGRNFLH--CAVEHNKESIVRYICR-------DDRF---------------- 353
Cdd:PHA03095  160 LKSRNANVEllrlLIDAGADVYA--VDDRFRSLLHhhLQSFKPRARIVRELIRagcdpaaTDMLgntplhsmatgssckr 237

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2756276124 354 ---------GILMNAMDNEGNTPLHLAAEYGHPRMVSLLLEtMSVDVAITNRDGLTAADLAYRH 408
Cdd:PHA03095  238 slvlplliaGISINARNRYGQTPLHYAAVFNNPRACRRLIA-LGADINAVSSDGNTPLSLMVRN 300
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 184-385 3.38e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 53.13  E-value: 3.38e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756276124 184 VSPLYLAATVGSVDIVRALLHplpDGTPSPASAAgpDGRTALHSAA------TTSKEIAREILdwkpEGRTLLTKADSSG 257
Cdd:PHA03100   36 VLPLYLAKEARNIDVVKILLD---NGADINSSTK--NNSTPLHYLSnikynlTDVKEIVKLLL----EYGANVNAPDNNG 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756276124 258 RTPLHFAISSQIERFDVFQLFLDAEPSLALVCDIQGSfPLHVAAVMGSVRI-VVELIQKcpNNYN--------------- 321
Cdd:PHA03100  107 ITPLLYAISKKSNSYSIVEYLLDNGANVNIKNSDGEN-LLHLYLESNKIDLkILKLLID--KGVDinaknrvnyllsygv 183

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2756276124 322 --DLVDDRGRNFLHCAVEHNKESIVRYICRddrFGILMNAMDNEGNTPLHLAAEYGHPRMVSLLLE 385
Cdd:PHA03100  184 piNIKDVYGFTPLHYAVYNNNPEFVKYLLD---LGANPNLVNKYGDTPLHIAILNNNKEIFKLLLN 246
Ank_2 pfam12796
Ankyrin repeats (3 copies);
261-348 3.79e-07

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 48.57  E-value: 3.79e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756276124 261 LHFAISSqiERFDVFQLFLDAEPSlALVCDIQGSFPLHVAAVMGSVRIVVELIQKCPNNyndlVDDRGRNFLHCAVEHNK 340
Cdd:pfam12796   1 LHLAAKN--GNLELVKLLLENGAD-ANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVN----LKDNGRTALHYAARSGH 73


                  ....*...
gi 2756276124 341 ESIVRYIC 348
Cdd:pfam12796  74 LEIVKLLL 81
Ank_5 pfam13857
Ankyrin repeats (many copies);
351-405 4.71e-07

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 46.96  E-value: 4.71e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2756276124 351 DRFGILMNAMDNEGNTPLHLAAEYGHPRMVSLLLEtMSVDVAITNRDGLTAADLA 405
Cdd:pfam13857   3 EHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLA-YGVDLNLKDEEGLTALDLA 56
PHA03095 PHA03095
ankyrin-like protein; Provisional
 104-386 7.91e-07

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 51.95  E-value: 7.91e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756276124 104 FLDTPLHCAAKSGHRDVAACLLSeMLRAGGAASAAlplrraTNClGATALHEAVRNGH-AGVVALLMAEAPELaSVANDG 182
Cdd:PHA03095   46 YGKTPLHLYLHYSSEKVKDIVRL-LLEAGADVNAP------ERC-GFTPLHLYLYNATtLDVIKLLIKAGADV-NAKDKV 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756276124 183 GVSPLYLAATVGSVD--IVRALLHPLPDgtpspASAAGPDGRTALHsAATTSKEIAREILdwkpegRTLLTK------AD 254
Cdd:PHA03095  117 GRTPLHVYLSGFNINpkVIRLLLRKGAD-----VNALDLYGMTPLA-VLLKSRNANVELL------RLLIDAgadvyaVD 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756276124 255 SSGRTPLH-FAISSQiERFDVFQLFLDAEPSLALVcDIQGSFPLHVAAVMGSVR--IVVELIQKcpNNYNDLVDDRGRNF 331
Cdd:PHA03095  185 DRFRSLLHhHLQSFK-PRARIVRELIRAGCDPAAT-DMLGNTPLHSMATGSSCKrsLVLPLLIA--GISINARNRYGQTP 260

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2756276124 332 LHCAVEHNKESIVRYICRddrFGILMNAMDNEGNTPLHLAAEYGHPRMVSLLLET 386
Cdd:PHA03095  261 LHYAAVFNNPRACRRLIA---LGADINAVSSDGNTPLSLMVRNNNGRAVRAALAK 312
Ank_2 pfam12796
Ankyrin repeats (3 copies);
65-126 1.09e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 47.03  E-value: 1.09e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2756276124  65 GVTTGNGNTALHVAATRGHAALAALVCATAPALAATRNRfldTPLHCAAKSGHRDVAACLLS 126
Cdd:pfam12796  24 NLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKDNGR---TALHYAARSGHLEIVKLLLE 82
Ank_4 pfam13637
Ankyrin repeats (many copies);
328-384 2.24e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 44.96  E-value: 2.24e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2756276124 328 GRNFLHCAVEHNKESIVRYiCRDdrFGILMNAMDNEGNTPLHLAAEYGHPRMVSLLL 384
Cdd:pfam13637   1 ELTALHAAAASGHLELLRL-LLE--KGADINAVDGNGETALHFAASNGNVEVLKLLL 54
TRPV3 cd22194
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a ...
 221-385 1.22e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a temperature-sensitive Transient Receptor Potential (TRP) ion channel that is activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants. TRPV3 function is regulated by physiological factors such as extracellular divalent cations and acidic pH, intracellular adenosine triphosphate, membrane voltage, and arachidonic acid. It is expressed in both neuronal and non-neuronal tissues including epidermal keratinocytes, epithelial cells in the gut, endothelial cells in blood vessels, and neurons in dorsal root ganglia and CNS. TRPV3 null mice have abnormal hair morphogenesis and compromised skin barrier function. It may play roles in inflammatory skin disorders, such as itch and pain sensation. TRPV3 is also expressed by many neuronal and non-neuronal tissues, showing that TRPV3 might play roles in other unknown cellular and physiological functions. TRPV3 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411978 [Multi-domain]  Cd Length: 680  Bit Score: 48.60  E-value: 1.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756276124 221 GRTALHSA----ATTSKEIAREILDWKPEGRTL-------LTKADSSGRTPLHFAIssqiER--FDVFQLFLDA------ 281
Cdd:cd22194    94 GKTCLMKAllniNENTKEIVRILLAFAEENGILdrfinaeYTEEAYEGQTALNIAI----ERrqGDIVKLLIAKgadvna 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756276124 282 -------EPSLALVCDIQGSFPLHVAAVMGSVRIVVELIQKCPNNYNdLVDDRGRNFLHCAV------EHNKESIVRY-- 346
Cdd:cd22194   170 hakgvffNPKYKHEGFYFGETPLALAACTNQPEIVQLLMEKESTDIT-SQDSRGNTVLHALVtvaedsKTQNDFVKRMyd 248

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 2756276124 347 -ICRDDRFGILMNAMDNEGNTPLHLAAEYGHPRMVSLLLE 385
Cdd:cd22194   249 mILLKSENKNLETIRNNEGLTPLQLAAKMGKAEILKYILS 288
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 259-405 2.43e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 47.75  E-value: 2.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756276124 259 TPLHFAIssQIERFDVFQLFLDAEPSLALVCDIQGSFPLHVAAVMGSVR-IVVELIQKCP------------NNY----- 320
Cdd:PHA02876   43 TAIHQAL--QLRQIDIVEEIIQQNPELIYITDHKCHSTLHTICIIPNVMdIVISLTLDCDiildikyasiilNKHkldea 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756276124 321 -----------NDLVDDRgrnfLHCAVEHNKeSIVRYICRDD--------RFGILMNAMDNEGNTPLHLAAEYGHPRMVS 381
Cdd:PHA02876  121 cihilkeaisgNDIHYDK----INESIEYMK-LIKERIQQDElliaemllEGGADVNAKDIYCITPIHYAAERGNAKMVN 195

                         170       180
                  ....*....|....*....|....
gi 2756276124 382 LLLeTMSVDVAITNRDGLTAADLA 405
Cdd:PHA02876  196 LLL-SYGADVNIIALDDLSVLECA 218
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 358-452 3.34e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 47.20  E-value: 3.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756276124 358 NAMDNEGNTPLHLAAEYGHPRMVSLLLEtMSVDVAITNRDGLTAADLAYRHlqpglhyflNPRAVVKNLFYCTRAPVTLE 437
Cdd:PTZ00322  109 NCRDYDGRTPLHIACANGHVQVVRVLLE-FGADPTLLDKDGKTPLELAEEN---------GFREVVQLLSRHSQCHFELG 178

                          90
                  ....*....|....*...
gi 2756276124 438 GDHAR---TGIPSAMEDA 452
Cdd:PTZ00322  179 ANAKPdsfTGKPPSLEDS 196
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
66-182 6.74e-05

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 45.33  E-value: 6.74e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756276124  66 VTTGNGNTALHVAATRGHAALAALVCAtAPALAATRNRFLDTPLHCAAKSGHRDVAACLLsemlraggaasAALPLRRAT 145
Cdd:COG0666   181 ARDNDGETPLHLAAENGHLEIVKLLLE-AGADVNAKDNDGKTALDLAAENGNLEIVKLLL-----------EAGADLNAK 248

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2756276124 146 NCLGATALHEAVRNGHAGVVALLMAEAPELASVANDG 182
Cdd:COG0666   249 DKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDL 285
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 185-405 1.69e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 44.62  E-value: 1.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756276124 185 SPLYLAATVGSVDIVRALLhplpdGTPS-PASAAGPDGRTALHSAATTSK-EIAREILDWKPEgrtLLTKADSSgrtplh 262
Cdd:cd22192    19 SPLLLAAKENDVQAIKKLL-----KCPScDLFQRGALGETALHVAALYDNlEAAVVLMEAAPE---LVNEPMTS------ 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756276124 263 faissqierfdvfQLFldaepslalvcdiQGSFPLHVAAVMGSVRIVVELIQKCPnnynDLVDDR--------------- 327
Cdd:cd22192    85 -------------DLY-------------QGETALHIAVVNQNLNLVRELIARGA----DVVSPRatgtffrpgpknliy 134

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756276124 328 -GRNFLHCAVEHNKESIVRYICRDdrfGILMNAMDNEGNTPLH---------LAAEyghprMVSLLL------ETMSVDV 391
Cdd:cd22192   135 yGEHPLSFAACVGNEEIVRLLIEH---GADIRAQDSLGNTVLHilvlqpnktFACQ-----MYDLILsydkedDLQPLDL 206

                         250
                  ....*....|....
gi 2756276124 392 aITNRDGLTAADLA 405
Cdd:cd22192   207 -VPNNQGLTPFKLA 219
Ank_4 pfam13637
Ankyrin repeats (many copies);
71-125 2.12e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.57  E-value: 2.12e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2756276124  71 GNTALHVAATRGH-AALAALVCATAPALAatRNRFLDTPLHCAAKSGHRDVAACLL 125
Cdd:pfam13637   1 ELTALHAAAASGHlELLRLLLEKGADINA--VDGNGETALHFAASNGNVEVLKLLL 54
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 107-315 3.04e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 44.10  E-value: 3.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756276124 107 TPLHCAAKSGHRDVAACLLSeMLRAGGAASAALPLRRATnCL-----GATALHEAVRNGHAGVVALLMAEAPELASVAND 181
Cdd:cd21882    28 TCLHKAALNLNDGVNEAIML-LLEAAPDSGNPKELVNAP-CTdefyqGQTALHIAIENRNLNLVRLLVENGADVSARATG 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756276124 182 G------------GVSPLYLAATVGSVDIVRALLHPLPDgtpsPASAAGPD--GRTALHsaattskeIAREILDWKPEGR 247
Cdd:cd21882   106 RffrkspgnlfyfGELPLSLAACTNQEEIVRLLLENGAQ----PAALEAQDslGNTVLH--------ALVLQADNTPENS 173

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2756276124 248 TLLTKadssgrtpLHFAISSQIERFDVFQlfldaepSLALVCDIQGSFPLHVAAVMGSVRIVVELIQK 315
Cdd:cd21882   174 AFVCQ--------MYNLLLSYGAHLDPTQ-------QLEEIPNHQGLTPLKLAAVEGKIVMFQHILQR 226
PHA03095 PHA03095
ankyrin-like protein; Provisional
 71-180 3.09e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 43.86  E-value: 3.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756276124  71 GNTALHVAATRGHAALAALVcataPALAA-----TRNRFLDTPLHCAAKSGHRDVAACLlsemLRAGGAASAalplrrAT 145
Cdd:PHA03095  222 GNTPLHSMATGSSCKRSLVL----PLLIAgisinARNRYGQTPLHYAAVFNNPRACRRL----IALGADINA------VS 287

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2756276124 146 NClGATALHEAVRNGHAGVVALLMAEAPELASVAN 180
Cdd:PHA03095  288 SD-GNTPLSLMVRNNNGRAVRAALAKNPSAETVAA 321
PHA02741 PHA02741
hypothetical protein; Provisional
 249-396 6.58e-04

hypothetical protein; Provisional


Pssm-ID: 165108 [Multi-domain]  Cd Length: 169  Bit Score: 41.18  E-value: 6.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756276124 249 LLTKADSSGRTPLHFAISSQ----IERFDVFqLFLDAEPSLALVCDIQGSFPLHVAAVMGSVRIVVELIQKCPN-----N 319
Cdd:PHA02741   13 MIAEKNSEGENFFHEAARCGcfdiIARFTPF-IRGDCHAAALNATDDAGQMCIHIAAEKHEAQLAAEIIDHLIElgadiN 91

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2756276124 320 YNDLVDdrGRNFLHCAVEHNKESIVRYICRDDRFGILMNAMDNEgnTPLHLAAEYGHPRMVSLLLETMSVDVAITNR 396
Cdd:PHA02741   92 AQEMLE--GDTALHLAAHRRDHDLAEWLCCQPGIDLHFCNADNK--SPFELAIDNEDVAMMQILREIVATSRGFSNE 164
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 363-385 8.22e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.18  E-value: 8.22e-04
                           10        20
                   ....*....|....*....|...
gi 2756276124  363 EGNTPLHLAAEYGHPRMVSLLLE 385
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLD 23
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 363-396 9.01e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 37.27  E-value: 9.01e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2756276124 363 EGNTPLHLAA-EYGHPRMVSLLLEtMSVDVAITNR 396
Cdd:pfam00023   1 DGNTPLHLAAgRRGNLEIVKLLLS-KGADVNARDK 34
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 153-395 9.14e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 42.29  E-value: 9.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756276124 153 LHEAVRNGHAGVVALLMAEAPELASVANDGGVSPLYLAATVGSVDIVRALLhplpdgtpspASAAGPDgrtalhsAATTS 232
Cdd:PHA02875   72 LHDAVEEGDVKAVEELLDLGKFADDVFYKDGMTPLHLATILKKLDIMKLLI----------ARGADPD-------IPNTD 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756276124 233 KEiareildwkpegrtlltkadssgrTPLHFAISSQieRFDVFQLFLDAEPSLALVcDIQGSFPLHVAAVMGSVRIVVEL 312
Cdd:PHA02875  135 KF------------------------SPLHLAVMMG--DIKGIELLIDHKACLDIE-DCCGCTPLIIAMAKGDIAICKML 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756276124 313 IQKCPNnyNDLVDDRGRNFLHC-AVEHNKESIVRYICRDDRFGILMNAMDNEGNTPLHLAAEYghprmvSLLLETMSVDV 391
Cdd:PHA02875  188 LDSGAN--IDYFGKNGCVAALCyAIENNKIDIVRLFIKRGADCNIMFMIEGEECTILDMICNM------CTNLESEAIDA 259


                  ....
gi 2756276124 392 AITN 395
Cdd:PHA02875  260 LIAD 263
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 363-393 1.06e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 36.85  E-value: 1.06e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 2756276124 363 EGNTPLHLAAEYGHPRMVSLLLEtMSVDVAI 393
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLE-NGADINA 30
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 292-407 1.35e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 41.79  E-value: 1.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756276124 292 QGSFPLHVAAVMGSVRIVVELIQKC--PNnyndlVDDRGRNF-LHCAVEHNKESIVRYICRDdrfGILMNAMDNEGNTPL 368
Cdd:PHA02878  167 KGNTALHYATENKDQRLTELLLSYGanVN-----IPDKTNNSpLHHAVKHYNKPIVHILLEN---GASTDARDKCGNTPL 238

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2756276124 369 HLAAEY-GHPRMVSLLLET-MSVDVAITNRdGLTAADLAYR 407
Cdd:PHA02878  239 HISVGYcKDYDILKLLLEHgVDVNAKSYIL-GLTALHSSIK 278
TRPV3 cd22194
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a ...
 149-282 1.46e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a temperature-sensitive Transient Receptor Potential (TRP) ion channel that is activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants. TRPV3 function is regulated by physiological factors such as extracellular divalent cations and acidic pH, intracellular adenosine triphosphate, membrane voltage, and arachidonic acid. It is expressed in both neuronal and non-neuronal tissues including epidermal keratinocytes, epithelial cells in the gut, endothelial cells in blood vessels, and neurons in dorsal root ganglia and CNS. TRPV3 null mice have abnormal hair morphogenesis and compromised skin barrier function. It may play roles in inflammatory skin disorders, such as itch and pain sensation. TRPV3 is also expressed by many neuronal and non-neuronal tissues, showing that TRPV3 might play roles in other unknown cellular and physiological functions. TRPV3 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411978 [Multi-domain]  Cd Length: 680  Bit Score: 41.67  E-value: 1.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756276124 149 GATALHEAVRNGHAGVVALLMAEAPELASVA----------NDG---GVSPLYLAATVGSVDIVRALLhplpDGTPSPAS 215
Cdd:cd22194   141 GQTALNIAIERRQGDIVKLLIAKGADVNAHAkgvffnpkykHEGfyfGETPLALAACTNQPEIVQLLM----EKESTDIT 216

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2756276124 216 AAGPDGRTALHSAATTS----------KEIAREILDwKPEGRTLLTKADSSGRTPLHFAisSQIERFDVFQLFLDAE 282
Cdd:cd22194   217 SQDSRGNTVLHALVTVAedsktqndfvKRMYDMILL-KSENKNLETIRNNEGLTPLQLA--AKMGKAEILKYILSRE 290
Ank_4 pfam13637
Ankyrin repeats (many copies);
364-417 1.56e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 36.87  E-value: 1.56e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2756276124 364 GNTPLHLAAEYGHPRMVSLLLETmSVDVAITNRDGLTAADLAYRHLQPG-LHYFL 417
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEK-GADINAVDGNGETALHFAASNGNVEvLKLLL 54
PHA02741 PHA02741
hypothetical protein; Provisional
 297-405 2.49e-03

hypothetical protein; Provisional


Pssm-ID: 165108 [Multi-domain]  Cd Length: 169  Bit Score: 39.26  E-value: 2.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756276124 297 LHVAAVMGSVRIVVELIQKCPNNYN----DLVDDRGRNFLH-CAVEHNKESIVRYICRDDRFGILMNAMDN-EGNTPLHL 370
Cdd:PHA02741   25 FHEAARCGCFDIIARFTPFIRGDCHaaalNATDDAGQMCIHiAAEKHEAQLAAEIIDHLIELGADINAQEMlEGDTALHL 104

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2756276124 371 AAEYGHPRMVSLLLETMSVDVAITNRDGLTAADLA 405
Cdd:PHA02741  105 AAHRRDHDLAEWLCCQPGIDLHFCNADNKSPFELA 139
Ank_2 pfam12796
Ankyrin repeats (3 copies);
254-315 2.52e-03

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 37.40  E-value: 2.52e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2756276124 254 DSSGRTPLHFAISSQieRFDVFQLFLDaepSLALVCDIQGSFPLHVAAVMGSVRIVVELIQK 315
Cdd:pfam12796  27 DKNGRTALHLAAKNG--HLEIVKLLLE---HADVNLKDNGRTALHYAARSGHLEIVKLLLEK 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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