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Conserved domains on  [gi|1034558520|ref|XP_016856762|]
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laminin subunit gamma-2 isoform X3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LamB smart00281
Laminin B domain;
245-370 1.62e-41

Laminin B domain;


:

Pssm-ID: 214597  Cd Length: 127  Bit Score: 147.41  E-value: 1.62e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034558520  245 RLDPVYFVAPAKFLGNQQVSYGQSLSFDYRVD--RGGRHPSAHDVILEGAGLRITAPLMplGKTLPCGLTK-TYTFRLNE 321
Cdd:smart00281   1 DNEPVYWVAPEQFLGDKVTSYGGKLRYTLSFDgrRGGTHVSAPDVILEGNGLRISHPAE--GPPLPDELTTvEVRFREEN 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1034558520  322 HPSNNWSPQLSYfEYRRLLRNLTALRIRATYGEYSTG-YIDNVTLISARP 370
Cdd:smart00281  79 WQYYGGRPVTRE-DLMMVLANLTAILIRATYSQQMAGsRLSDVSLEVAVP 127
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 83-127 5.94e-10

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 55.05  E-value: 5.94e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1034558520  83 PCNCNSKGSLSARCD-NSGRCSCKPGVTGARCDRCLPGFHMLTDAG 127
Cdd:cd00055     1 PCDCNGHGSLSGQCDpGTGQCECKPNTTGRRCDRCAPGYYGLPSQG 46
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 139-184 5.00e-09

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 52.36  E-value: 5.00e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1034558520 139 CDCDPAGIAGP-CDA--GRCVCKPAVTGERCDRCRSGYYNLDGGNPEGC 184
Cdd:pfam00053   1 CDCNPHGSLSDtCDPetGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 516-565 3.81e-08

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 50.05  E-value: 3.81e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1034558520 516 PCQCNNNvdPSASGNCDRLTGRCLkCIHNTAGIYCDQCKAGYFGDPLAPN 565
Cdd:cd00055     1 PCDCNGH--GSLSGQCDPGTGQCE-CKPNTTGRRCDRCAPGYYGLPSQGG 47
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 461-509 7.44e-05

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 40.80  E-value: 7.44e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1034558520 461 PCPCHNGFSCSVMPETEEVVCNnCPPGVTGARCELCADGYFGDPFGEHG 509
Cdd:cd00055     1 PCDCNGHGSLSGQCDPGTGQCE-CKPNTTGRRCDRCAPGYYGLPSQGGG 48
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 572-604 3.55e-04

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 38.87  E-value: 3.55e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1034558520 572 ACNCNPMGSEPVGC-RSDGTCVCKPGFGGPNCEH 604
Cdd:cd00055     1 PCDCNGHGSLSGQCdPGTGQCECKPNTTGRRCDR 34
 
Name Accession Description Interval E-value
LamB smart00281
Laminin B domain;
245-370 1.62e-41

Laminin B domain;


Pssm-ID: 214597  Cd Length: 127  Bit Score: 147.41  E-value: 1.62e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034558520  245 RLDPVYFVAPAKFLGNQQVSYGQSLSFDYRVD--RGGRHPSAHDVILEGAGLRITAPLMplGKTLPCGLTK-TYTFRLNE 321
Cdd:smart00281   1 DNEPVYWVAPEQFLGDKVTSYGGKLRYTLSFDgrRGGTHVSAPDVILEGNGLRISHPAE--GPPLPDELTTvEVRFREEN 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1034558520  322 HPSNNWSPQLSYfEYRRLLRNLTALRIRATYGEYSTG-YIDNVTLISARP 370
Cdd:smart00281  79 WQYYGGRPVTRE-DLMMVLANLTAILIRATYSQQMAGsRLSDVSLEVAVP 127
Laminin_B pfam00052
Laminin B (Domain IV);
250-380 1.87e-37

Laminin B (Domain IV);


Pssm-ID: 459652  Cd Length: 136  Bit Score: 136.25  E-value: 1.87e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034558520 250 YFVAPAKFLGNQQVSYGQSLSFDYRVDRGGRHPSAH---DVILEGAGLRITAPLMPLGKTLPcGLTKTYTFRLNEHpsnN 326
Cdd:pfam00052   1 YWSAPEQFLGNKLTSYGGYLTYTVRYEPLPGGGSLNsepDVILEGNGLRLSYSSPDQPPPDP-GQEQTYSVRLHEE---N 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034558520 327 W----SPQLSYFEYRRLLRNLTALRIRATYGEYSTG-YIDNVTLISARP-VSGAPAPWVE 380
Cdd:pfam00052  77 WrdsdGAPVSREDFMMVLANLTAILIRATYSTGSGQvSLSNVSLDSAVPgGSGPPASWVE 136
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 83-127 5.94e-10

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 55.05  E-value: 5.94e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1034558520  83 PCNCNSKGSLSARCD-NSGRCSCKPGVTGARCDRCLPGFHMLTDAG 127
Cdd:cd00055     1 PCDCNGHGSLSGQCDpGTGQCECKPNTTGRRCDRCAPGYYGLPSQG 46
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
84-128 1.71e-09

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 53.85  E-value: 1.71e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1034558520   84 CNCNSKGSLSARCD-NSGRCSCKPGVTGARCDRCLPGFHMLTDAGC 128
Cdd:smart00180   1 CDCDPGGSASGTCDpDTGQCECKPNVTGRRCDRCAPGYYGDGPPGC 46
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 84-123 3.41e-09

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 53.13  E-value: 3.41e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1034558520  84 CNCNSKGSLSARCD-NSGRCSCKPGVTGARCDRCLPGFHML 123
Cdd:pfam00053   1 CDCNPHGSLSDTCDpETGQCLCKPGVTGRHCDRCKPGYYGL 41
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 139-184 5.00e-09

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 52.36  E-value: 5.00e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1034558520 139 CDCDPAGIAGP-CDA--GRCVCKPAVTGERCDRCRSGYYNLDGGNPEGC 184
Cdd:pfam00053   1 CDCNPHGSLSDtCDPetGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 516-565 3.81e-08

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 50.05  E-value: 3.81e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1034558520 516 PCQCNNNvdPSASGNCDRLTGRCLkCIHNTAGIYCDQCKAGYFGDPLAPN 565
Cdd:cd00055     1 PCDCNGH--GSLSGQCDPGTGQCE-CKPNTTGRRCDRCAPGYYGLPSQGG 47
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 517-564 1.91e-07

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 48.12  E-value: 1.91e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1034558520 517 CQCNNNVdpSASGNCDRLTGRCLkCIHNTAGIYCDQCKAGYFGDPLAP 564
Cdd:pfam00053   1 CDCNPHG--SLSDTCDPETGQCL-CKPGVTGRHCDRCKPGYYGLPSDP 45
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
139-184 2.77e-07

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 47.69  E-value: 2.77e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1034558520  139 CDCDPAGIAGP-CDA--GRCVCKPAVTGERCDRCRSGYYnldGGNPEGC 184
Cdd:smart00180   1 CDCDPGGSASGtCDPdtGQCECKPNVTGRRCDRCAPGYY---GDGPPGC 46
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 139-185 1.17e-06

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 45.81  E-value: 1.17e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1034558520 139 CDCDPAGIAGP-CDA--GRCVCKPAVTGERCDRCRSGYYNLDgGNPEGCT 185
Cdd:cd00055     2 CDCNGHGSLSGqCDPgtGQCECKPNTTGRRCDRCAPGYYGLP-SQGGGCQ 50
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
517-561 1.20e-05

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 43.07  E-value: 1.20e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1034558520  517 CQCNnnVDPSASGNCDRLTGRCLkCIHNTAGIYCDQCKAGYFGDP 561
Cdd:smart00180   1 CDCD--PGGSASGTCDPDTGQCE-CKPNVTGRRCDRCAPGYYGDG 42
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 461-509 7.44e-05

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 40.80  E-value: 7.44e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1034558520 461 PCPCHNGFSCSVMPETEEVVCNnCPPGVTGARCELCADGYFGDPFGEHG 509
Cdd:cd00055     1 PCDCNGHGSLSGQCDPGTGQCE-CKPNTTGRRCDRCAPGYYGLPSQGGG 48
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 572-604 3.55e-04

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 38.87  E-value: 3.55e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1034558520 572 ACNCNPMGSEPVGC-RSDGTCVCKPGFGGPNCEH 604
Cdd:cd00055     1 PCDCNGHGSLSGQCdPGTGQCECKPNTTGRRCDR 34
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
462-508 4.60e-04

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 38.45  E-value: 4.60e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1034558520  462 CPCHNGFSCSVMPETEEVVCNnCPPGVTGARCELCADGYFGDPFGEH 508
Cdd:smart00180   1 CDCDPGGSASGTCDPDTGQCE-CKPNVTGRRCDRCAPGYYGDGPPGC 46
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 573-604 1.18e-03

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 37.33  E-value: 1.18e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1034558520 573 CNCNPMGSEPVGC-RSDGTCVCKPGFGGPNCEH 604
Cdd:pfam00053   1 CDCNPHGSLSDTCdPETGQCLCKPGVTGRHCDR 33
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
573-604 2.48e-03

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 36.52  E-value: 2.48e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1034558520  573 CNCNPMGSEPVGCRSD-GTCVCKPGFGGPNCEH 604
Cdd:smart00180   1 CDCDPGGSASGTCDPDtGQCECKPNVTGRRCDR 33
 
Name Accession Description Interval E-value
LamB smart00281
Laminin B domain;
245-370 1.62e-41

Laminin B domain;


Pssm-ID: 214597  Cd Length: 127  Bit Score: 147.41  E-value: 1.62e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034558520  245 RLDPVYFVAPAKFLGNQQVSYGQSLSFDYRVD--RGGRHPSAHDVILEGAGLRITAPLMplGKTLPCGLTK-TYTFRLNE 321
Cdd:smart00281   1 DNEPVYWVAPEQFLGDKVTSYGGKLRYTLSFDgrRGGTHVSAPDVILEGNGLRISHPAE--GPPLPDELTTvEVRFREEN 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1034558520  322 HPSNNWSPQLSYfEYRRLLRNLTALRIRATYGEYSTG-YIDNVTLISARP 370
Cdd:smart00281  79 WQYYGGRPVTRE-DLMMVLANLTAILIRATYSQQMAGsRLSDVSLEVAVP 127
Laminin_B pfam00052
Laminin B (Domain IV);
250-380 1.87e-37

Laminin B (Domain IV);


Pssm-ID: 459652  Cd Length: 136  Bit Score: 136.25  E-value: 1.87e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034558520 250 YFVAPAKFLGNQQVSYGQSLSFDYRVDRGGRHPSAH---DVILEGAGLRITAPLMPLGKTLPcGLTKTYTFRLNEHpsnN 326
Cdd:pfam00052   1 YWSAPEQFLGNKLTSYGGYLTYTVRYEPLPGGGSLNsepDVILEGNGLRLSYSSPDQPPPDP-GQEQTYSVRLHEE---N 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034558520 327 W----SPQLSYFEYRRLLRNLTALRIRATYGEYSTG-YIDNVTLISARP-VSGAPAPWVE 380
Cdd:pfam00052  77 WrdsdGAPVSREDFMMVLANLTAILIRATYSTGSGQvSLSNVSLDSAVPgGSGPPASWVE 136
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 83-127 5.94e-10

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 55.05  E-value: 5.94e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1034558520  83 PCNCNSKGSLSARCD-NSGRCSCKPGVTGARCDRCLPGFHMLTDAG 127
Cdd:cd00055     1 PCDCNGHGSLSGQCDpGTGQCECKPNTTGRRCDRCAPGYYGLPSQG 46
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
84-128 1.71e-09

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 53.85  E-value: 1.71e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1034558520   84 CNCNSKGSLSARCD-NSGRCSCKPGVTGARCDRCLPGFHMLTDAGC 128
Cdd:smart00180   1 CDCDPGGSASGTCDpDTGQCECKPNVTGRRCDRCAPGYYGDGPPGC 46
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 84-123 3.41e-09

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 53.13  E-value: 3.41e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1034558520  84 CNCNSKGSLSARCD-NSGRCSCKPGVTGARCDRCLPGFHML 123
Cdd:pfam00053   1 CDCNPHGSLSDTCDpETGQCLCKPGVTGRHCDRCKPGYYGL 41
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 139-184 5.00e-09

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 52.36  E-value: 5.00e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1034558520 139 CDCDPAGIAGP-CDA--GRCVCKPAVTGERCDRCRSGYYNLDGGNPEGC 184
Cdd:pfam00053   1 CDCNPHGSLSDtCDPetGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 516-565 3.81e-08

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 50.05  E-value: 3.81e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1034558520 516 PCQCNNNvdPSASGNCDRLTGRCLkCIHNTAGIYCDQCKAGYFGDPLAPN 565
Cdd:cd00055     1 PCDCNGH--GSLSGQCDPGTGQCE-CKPNTTGRRCDRCAPGYYGLPSQGG 47
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 517-564 1.91e-07

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 48.12  E-value: 1.91e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1034558520 517 CQCNNNVdpSASGNCDRLTGRCLkCIHNTAGIYCDQCKAGYFGDPLAP 564
Cdd:pfam00053   1 CDCNPHG--SLSDTCDPETGQCL-CKPGVTGRHCDRCKPGYYGLPSDP 45
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
139-184 2.77e-07

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 47.69  E-value: 2.77e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1034558520  139 CDCDPAGIAGP-CDA--GRCVCKPAVTGERCDRCRSGYYnldGGNPEGC 184
Cdd:smart00180   1 CDCDPGGSASGtCDPdtGQCECKPNVTGRRCDRCAPGYY---GDGPPGC 46
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 139-185 1.17e-06

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 45.81  E-value: 1.17e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1034558520 139 CDCDPAGIAGP-CDA--GRCVCKPAVTGERCDRCRSGYYNLDgGNPEGCT 185
Cdd:cd00055     2 CDCNGHGSLSGqCDPgtGQCECKPNTTGRRCDRCAPGYYGLP-SQGGGCQ 50
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
517-561 1.20e-05

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 43.07  E-value: 1.20e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1034558520  517 CQCNnnVDPSASGNCDRLTGRCLkCIHNTAGIYCDQCKAGYFGDP 561
Cdd:smart00180   1 CDCD--PGGSASGTCDPDTGQCE-CKPNVTGRRCDRCAPGYYGDG 42
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 461-509 7.44e-05

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 40.80  E-value: 7.44e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1034558520 461 PCPCHNGFSCSVMPETEEVVCNnCPPGVTGARCELCADGYFGDPFGEHG 509
Cdd:cd00055     1 PCDCNGHGSLSGQCDPGTGQCE-CKPNTTGRRCDRCAPGYYGLPSQGGG 48
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 572-604 3.55e-04

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 38.87  E-value: 3.55e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1034558520 572 ACNCNPMGSEPVGC-RSDGTCVCKPGFGGPNCEH 604
Cdd:cd00055     1 PCDCNGHGSLSGQCdPGTGQCECKPNTTGRRCDR 34
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
462-508 4.60e-04

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 38.45  E-value: 4.60e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1034558520  462 CPCHNGFSCSVMPETEEVVCNnCPPGVTGARCELCADGYFGDPFGEH 508
Cdd:smart00180   1 CDCDPGGSASGTCDPDTGQCE-CKPNVTGRRCDRCAPGYYGDGPPGC 46
TNFRSF4 cd13406
Tumor necrosis factor receptor superfamily member 4 (TNFRSF4), also known as CD134 or OXO40; ...
 437-517 1.03e-03

Tumor necrosis factor receptor superfamily member 4 (TNFRSF4), also known as CD134 or OXO40; TNFRSF4 (also known as OX40, ACT35, CD134, IMD16, TXGP1L) activates NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. It also promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. It is primarily expressed on activated CD4+ and CD8+ T cells, where it is transiently expressed and upregulated on the most recently antigen-activated T cells within inflammatory lesions. This makes it an attractive target to modulate immune responses, i.e. TNFRSF4 (OX40) blocking agents to inhibit adverse inflammation or agonists to enhance immune responses. An artificially created biologic fusion protein, OX40-immunoglobulin (OX40-Ig), prevents OX40 from reaching the T-cell receptors, thus reducing the T-cell response. Some single nucleotide polymorphisms (SNPs) of its natural ligand OX40 ligand (OX40L, CD252), which is also found on activated T cells, have been associated with systemic lupus erythematosus.


Pssm-ID: 276911 [Multi-domain]  Cd Length: 142  Bit Score: 40.07  E-value: 1.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034558520 437 NPDIECADCPIGFYNDPHDPRSCKPCPCHNGFSCSVMPE----TEEVVCnNCPPGVT-------GARCELCADGYFGDpf 505
Cdd:cd13406    31 TQDTVCSPCEPGFYNEAVNYEPCKPCTQCNQRSGSEEKQkctkTSDTVC-RCRPGTQpldsykpGVDCVPCPPGHFSR-- 107

                          90
                  ....*....|..
gi 1034558520 506 GEHGPVRPCQPC 517
Cdd:cd13406   108 GDNQACKPWTNC 119
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 573-604 1.18e-03

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 37.33  E-value: 1.18e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1034558520 573 CNCNPMGSEPVGC-RSDGTCVCKPGFGGPNCEH 604
Cdd:pfam00053   1 CDCNPHGSLSDTCdPETGQCLCKPGVTGRHCDR 33
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
573-604 2.48e-03

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 36.52  E-value: 2.48e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1034558520  573 CNCNPMGSEPVGCRSD-GTCVCKPGFGGPNCEH 604
Cdd:smart00180   1 CDCDPGGSASGTCDPDtGQCECKPNVTGRRCDR 33
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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