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Conserved domains on  [gi|2217287858|ref|XP_016874419|]
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ATP-dependent DNA helicase DDX11 isoform X13 [Homo sapiens]

Protein Classification

DEAD/DEAH box helicase( domain architecture ID 1003081)

DEAD/DEAH box containing ATP-dependent helicase catalyzes the unwinding of DNA or RNA; similar to human ATP-dependent DNA helicase DDX11

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
rad3 super family cl36704
DNA repair helicase (rad3); All proteins in this family for which funcitons are known are ...
240-966 1.29e-149

DNA repair helicase (rad3); All proteins in this family for which funcitons are known are DNA-DNA helicases that funciton in the initiation of transcription and nucleotide excision repair as part of the TFIIH complex. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


The actual alignment was detected with superfamily member TIGR00604:

Pssm-ID: 273169 [Multi-domain]  Cd Length: 705  Bit Score: 460.34  E-value: 1.29e-149
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217287858 240 TKIYYCSRTHSQLAQFVHEVKK--SPFGK------DVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSRHEKKkg 311
Cdd:TIGR00604  61 RKIIYASRTHSQLEQATEELRKlmSYRTPrigeesPVSGLSLASRKNLCLHPEVSKERQGKVVNGKCIKLTVSKIKEQ-- 138
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217287858 312 aeeekpkRRRQEKQAACPFY-NHEQMGLLRDEALAEVKDMEQLLALGKEARACPYYGSRLAIPAAQLVVLPYQMLLHAAT 390
Cdd:TIGR00604 139 -------RTEKPNVESCEFYeNFDELREVEDLLLSEIMDIEDLVEYGELLGLCPYFATRKMLPFANIVLLPYQYLLDPKI 211
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217287858 391 RQAAGIRLQDQVVIIDEAHNLIDTITGMHSVEVSGSQLCQAHSQLLQYVERYGKRLKAKNLMYLKQILYLLEKFVAVlgg 470
Cdd:TIGR00604 212 RSAVSIELKDSIVIFDEAHNLDNVCISSLSSNLSVRSLKRCSKEIAEYFEKIEERKEVDARKLLDELQKLVEGLKQE--- 288
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217287858 471 NIKQNPNTQSLSQTGTELKTINDFLFQSQIDNINLFKVQRYCEKSMISRKLFGFTERYGAVFSSR--EQPKLAGFQQFLQ 548
Cdd:TIGR00604 289 DLLTDEDIFLANPVLPKEVLPEAVPGNIRIAEIFLHKLSRYLEYLKDALKVLGVVSELPDAFLEHlkEKTFIDRPLRFCS 368
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217287858 549 SlqpRTTEAL--AAPADESQAStlrPASPLMHIQGFLAALTTANQDGRvILSRQGSLSQSTLKFLLLNPAVHFAQVVKEC 626
Cdd:TIGR00604 369 E---RLSNLLreLEITHPEDFS---ALVLLFTFATLVLTYTNGFLEGI-EPYENKTVPNPILKFMCLDPSIALKPLFERV 441
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217287858 627 RAVVIAGGTMQPAAGAVETplllhsvapgshvsqrklfcgfklkeknhdstfkrcltsgsscwpvpgwklsawwsfpvcl 706
Cdd:TIGR00604 442 RSVILASGTLSPLDAFPRN------------------------------------------------------------- 460
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217287858 707 aahlhLQFSAPPWLLPGHVIPPDNILPLVICSGISNQPLEFTFQKRELPQMMDEVGRILCNLCGVVPGGVVCFFPSYEYL 786
Cdd:TIGR00604 461 -----LGFNPVSQDSPTHILKRENLLTLIVTRGSDQVPLSSTFEIRNDPSLVRNLGELLVEFSKIIPDGIVVFFPSYSYL 535
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217287858 787 RQVHAHWEKGGLLGRLAARKKIFQEPKSAHQVEQVLLAYSrciQACGQERgqvtGALLLSVVGGKMSEGINFSDNLGRCV 866
Cdd:TIGR00604 536 ENIVSTWKEMGILENIEKKKLIFVETKDAQETSDALERYK---QAVSEGR----GAVLLSVAGGKVSEGIDFCDDLGRAV 608
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217287858 867 VMVGMPFPNIRSAELQEKMAYLDQTLPRAPGQappgkALVENLCMKAVNQSIGRAIRHQKDFASVVLLDQRYARPPVLAK 946
Cdd:TIGR00604 609 IMVGIPYEYTESRILLARLEFLRDQYPIRENQ-----DFYEFDAMRAVNQAIGRVIRHKDDYGSIVLLDKRYARSNKRKK 683
                         730       740
                  ....*....|....*....|
gi 2217287858 947 LPAWIRARVEVKATFGPAIA 966
Cdd:TIGR00604 684 LPKWIQDTIQSSDLNGMAIS 703
 
Name Accession Description Interval E-value
rad3 TIGR00604
DNA repair helicase (rad3); All proteins in this family for which funcitons are known are ...
240-966 1.29e-149

DNA repair helicase (rad3); All proteins in this family for which funcitons are known are DNA-DNA helicases that funciton in the initiation of transcription and nucleotide excision repair as part of the TFIIH complex. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273169 [Multi-domain]  Cd Length: 705  Bit Score: 460.34  E-value: 1.29e-149
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217287858 240 TKIYYCSRTHSQLAQFVHEVKK--SPFGK------DVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSRHEKKkg 311
Cdd:TIGR00604  61 RKIIYASRTHSQLEQATEELRKlmSYRTPrigeesPVSGLSLASRKNLCLHPEVSKERQGKVVNGKCIKLTVSKIKEQ-- 138
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217287858 312 aeeekpkRRRQEKQAACPFY-NHEQMGLLRDEALAEVKDMEQLLALGKEARACPYYGSRLAIPAAQLVVLPYQMLLHAAT 390
Cdd:TIGR00604 139 -------RTEKPNVESCEFYeNFDELREVEDLLLSEIMDIEDLVEYGELLGLCPYFATRKMLPFANIVLLPYQYLLDPKI 211
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217287858 391 RQAAGIRLQDQVVIIDEAHNLIDTITGMHSVEVSGSQLCQAHSQLLQYVERYGKRLKAKNLMYLKQILYLLEKFVAVlgg 470
Cdd:TIGR00604 212 RSAVSIELKDSIVIFDEAHNLDNVCISSLSSNLSVRSLKRCSKEIAEYFEKIEERKEVDARKLLDELQKLVEGLKQE--- 288
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217287858 471 NIKQNPNTQSLSQTGTELKTINDFLFQSQIDNINLFKVQRYCEKSMISRKLFGFTERYGAVFSSR--EQPKLAGFQQFLQ 548
Cdd:TIGR00604 289 DLLTDEDIFLANPVLPKEVLPEAVPGNIRIAEIFLHKLSRYLEYLKDALKVLGVVSELPDAFLEHlkEKTFIDRPLRFCS 368
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217287858 549 SlqpRTTEAL--AAPADESQAStlrPASPLMHIQGFLAALTTANQDGRvILSRQGSLSQSTLKFLLLNPAVHFAQVVKEC 626
Cdd:TIGR00604 369 E---RLSNLLreLEITHPEDFS---ALVLLFTFATLVLTYTNGFLEGI-EPYENKTVPNPILKFMCLDPSIALKPLFERV 441
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217287858 627 RAVVIAGGTMQPAAGAVETplllhsvapgshvsqrklfcgfklkeknhdstfkrcltsgsscwpvpgwklsawwsfpvcl 706
Cdd:TIGR00604 442 RSVILASGTLSPLDAFPRN------------------------------------------------------------- 460
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217287858 707 aahlhLQFSAPPWLLPGHVIPPDNILPLVICSGISNQPLEFTFQKRELPQMMDEVGRILCNLCGVVPGGVVCFFPSYEYL 786
Cdd:TIGR00604 461 -----LGFNPVSQDSPTHILKRENLLTLIVTRGSDQVPLSSTFEIRNDPSLVRNLGELLVEFSKIIPDGIVVFFPSYSYL 535
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217287858 787 RQVHAHWEKGGLLGRLAARKKIFQEPKSAHQVEQVLLAYSrciQACGQERgqvtGALLLSVVGGKMSEGINFSDNLGRCV 866
Cdd:TIGR00604 536 ENIVSTWKEMGILENIEKKKLIFVETKDAQETSDALERYK---QAVSEGR----GAVLLSVAGGKVSEGIDFCDDLGRAV 608
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217287858 867 VMVGMPFPNIRSAELQEKMAYLDQTLPRAPGQappgkALVENLCMKAVNQSIGRAIRHQKDFASVVLLDQRYARPPVLAK 946
Cdd:TIGR00604 609 IMVGIPYEYTESRILLARLEFLRDQYPIRENQ-----DFYEFDAMRAVNQAIGRVIRHKDDYGSIVLLDKRYARSNKRKK 683
                         730       740
                  ....*....|....*....|
gi 2217287858 947 LPAWIRARVEVKATFGPAIA 966
Cdd:TIGR00604 684 LPKWIQDTIQSSDLNGMAIS 703
DEXDc2 smart00488
DEAD-like helicases superfamily;
24-450 6.13e-103

DEAD-like helicases superfamily;


Pssm-ID: 214693 [Multi-domain]  Cd Length: 289  Bit Score: 323.18  E-value: 6.13e-103
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217287858   24 IHFPFPFTPYSIQEDFMAELYRVLEAGKIGIFESPTGTGKSLSLICGALSWLRDFEQKKreeearlletgtgplhdekde 103
Cdd:smart00488   1 LLFYFPYEPYPIQYEFMEELKRVLDRGKIGILESPTGTGKTLSLLCLTLTWLRSFPERI--------------------- 59
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217287858  104 slclssscegaagtprPAGEPAWVTQFVqkkeerdlvdrlkaeqarrKQREERLQQLQHRVQLKyaakrlrqeeeerenl 183
Cdd:smart00488  60 ----------------QKIKLIYLSRTV-------------------SEIEKRLEELRKLMQKV---------------- 88
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217287858  184 lrlsremletgpeaerleqlesgeeelvlaEYESDEEkkvasrvdededdleeehitkiyycsrtHSQLAQFVHEVKKsp 263
Cdd:smart00488  89 ------------------------------EYESDEE----------------------------SEKQAQLLHELGR-- 108
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217287858  264 FGKDVRLVSLGSRQNLCVNEDVKSLGSVQLIND-RCVDMQRSRHEKKkgaeeekpkRRRQEKQAACPFYNHEQMGLLRDE 342
Cdd:smart00488 109 EKPKVLGLSLTSRKNLCLNPEVRTLKQNGLVVDeVCRSLTASKARKY---------RYENPKVERCPFYENTEFLLVRDL 179
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217287858  343 ALAEVKDMEQLLALGKEARACPYYGSRLAIPAAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAHNLIDTITGMHSVE 422
Cdd:smart00488 180 LPAEVYDIEDLLELGKRLGGCPYFASRKAIEFANVVVLPYQYLLDPKIRQALSIELKDSIVIFDEAHNLDNVCISALSSE 259
                          410       420       430
                   ....*....|....*....|....*....|
gi 2217287858  423 VSGSQLCQAHSQLLQYVERYGK--RLKAKN 450
Cdd:smart00488 260 LSRRSLERAHKNIKKYFERIEKirENDAKR 289
DEAD_2 pfam06733
DEAD_2; This represents a conserved region within a number of RAD3-like DNA-binding helicases ...
244-428 4.74e-72

DEAD_2; This represents a conserved region within a number of RAD3-like DNA-binding helicases that are seemingly ubiquitous - members include proteins of eukaryotic, bacterial and archaeal origin. RAD3 is involved in nucleotide excision repair, and forms part of the transcription factor TFIIH in yeast.


Pssm-ID: 399602 [Multi-domain]  Cd Length: 168  Bit Score: 235.62  E-value: 4.74e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217287858 244 YCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSRHEkkkgaeeekpkrrrqe 323
Cdd:pfam06733   1 YCSRTHSQLEQVVKELRRLPYYKKIRGLILGSRKNLCINPEVLKLKKGNLVNERCRELVKSKAR---------------- 64
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217287858 324 kqAACPFY-NHEQMGLLRDEALAEVKDMEQLLALGKEARACPYYGSRLAIPAAQLVVLPYQMLLHAATRQAAGIRLQDQV 402
Cdd:pfam06733  65 --GSCPFYnNLEDLLKLRDLLGDEVMDIEDLVELGEKLGICPYYLSRELIPDADIIILPYNYLLDPKIRESLSINLKNSI 142
                         170       180
                  ....*....|....*....|....*.
gi 2217287858 403 VIIDEAHNLIDTITGMHSVEVSGSQL 428
Cdd:pfam06733 143 VIFDEAHNIEDVCIESASFSISRSQL 168
SF2_C_XPD cd18788
C-terminal helicase domain of xeroderma pigmentosum group D (XPD) family DEAD-like helicases; ...
729-938 1.87e-63

C-terminal helicase domain of xeroderma pigmentosum group D (XPD) family DEAD-like helicases; The xeroderma pigmentosum group D (XPD)-like family members are DEAD-box helicases belonging to superfamily (SF)2. This family includes DDX11 (also called ChlR1), a protein involved in maintaining chromosome transmission fidelity and genome stability, the TFIIH basal transcription factor complex XPD subunit, and FANCJ (also known as BRIP1), a DNA helicase required for the maintenance of chromosomal stability. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350175 [Multi-domain]  Cd Length: 159  Bit Score: 211.31  E-value: 1.87e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217287858 729 DNILPLVICSGISNQPLEFTFQKRELPQMMDEVGRILCNLCGVVPGGVVCFFPSYEYLRQVHAhwekggllgrlaarkki 808
Cdd:cd18788     1 DQVCPGIVGRGPDQQALNSKFQTREDEAVMDELGNLLLELCAVVPDGVLVFFPSYSYMERVVS----------------- 63
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217287858 809 fqepksahqveqvllaysrciqacgqergqvTGALLLSVVGGKMSEGINFSDNLGRCVVMVGMPFPNIRSAELQEKMAYL 888
Cdd:cd18788    64 -------------------------------RGALLLAVCRGKVSEGIDFSDDLGRAVIMVGIPYPNTKDPILKLKMDDL 112
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 2217287858 889 DqtLPRAPGQaPPGKALVENLCMKAVNQSIGRAIRHQKDFASVVLLDQRY 938
Cdd:cd18788   113 E--YLRDKGL-LTGEDWYTFQAMRAVNQAIGRAIRHKNDYGAIVLLDKRF 159
DinG COG1199
Rad3-related DNA helicase DinG [Replication, recombination and repair];
360-961 2.21e-22

Rad3-related DNA helicase DinG [Replication, recombination and repair];


Pssm-ID: 440812 [Multi-domain]  Cd Length: 629  Bit Score: 103.08  E-value: 2.21e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217287858 360 ARACPYYGSRLAIPAAQLVVLPYQMLL-HAATRQAagIRLQDQVVIIDEAHNLIDTITGMHSVEVSGSQLcqahSQLLQY 438
Cdd:COG1199   173 YGVCPYELARRLAREADVVVVNHHLLFaDLALGEE--LLPEDDVLIIDEAHNLPDRARDMFSAELSSRSL----LRLLRE 246
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217287858 439 VERYGKRLKAKNLMY-LKQILYLLEKFVAVLGGNIKQNPNTQSLSQTGTELKTINDFLFQSqidninLFKVQRYCEKSMi 517
Cdd:COG1199   247 LRKLGLRPGLKKLLDlLERLREALDDLFLALEEEEELRLALGELPDEPEELLEALDALRDA------LEALAEALEEEL- 319
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217287858 518 srklfgfterygavfssREQPKLAGFQQFLQSLQPRTTEALAAPADEsqastlrpasplmhiqGFLAALTTANQDGRVIL 597
Cdd:COG1199   320 -----------------ERLAELDALLERLEELLFALARFLRIAEDE----------------GYVRWLEREGGDVRLHA 366
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217287858 598 SrqgslsqstlkflLLNPAVHFAQVV-KECRAVVIAGGTMqpaagAVETPLllhsvapgSHVSQRklfCGFKLK--EKNH 674
Cdd:COG1199   367 A-------------PLDPADLLRELLfSRARSVVLTSATL-----SVGGPF--------DYFARR---LGLDEDarTLSL 417
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217287858 675 DSTFkrcltsgsscwpvpgwklsawwsfpvclaahlhlqfsappwllpghviPPDNILPLVICSGISnQPleftfqkREL 754
Cdd:COG1199   418 PSPF------------------------------------------------DYENQALLYVPRDLP-RP-------SDR 441
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217287858 755 PQMMDEVGRILCNLCGVVPGGVVCFFPSYEYLRQVHAhwekggllgRLAARKKI---FQEPKSAHQveqvLLAYSRciqa 831
Cdd:COG1199   442 DGYLEAIAEAIAELLEASGGNTLVLFTSYRALEQVAE---------LLRERLDIpvlVQGDGSREA----LLERFR---- 504
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217287858 832 cgqERGqvtGALLLSvvGGKMSEGINFSDNLGRCVVMVGMPFPNIRSAELQEKMAYLDQ---------TLPRApgqappg 902
Cdd:COG1199   505 ---EGG---NSVLVG--TGSFWEGVDLPGDALSLVIIVKLPFPPPDDPVLEARREALEArggngfmyaYLPPA------- 569
                         570       580       590       600       610       620
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217287858 903 kalvenlcMKAVNQSIGRAIRHQKDFASVVLLDQRYARPPV----LAKLPAWIRARVEVKATF 961
Cdd:COG1199   570 --------VIKLKQGAGRLIRSEEDRGVVVLLDRRLLTKRYgkrfLDSLPPFRRTRPEELRAF 624
 
Name Accession Description Interval E-value
rad3 TIGR00604
DNA repair helicase (rad3); All proteins in this family for which funcitons are known are ...
240-966 1.29e-149

DNA repair helicase (rad3); All proteins in this family for which funcitons are known are DNA-DNA helicases that funciton in the initiation of transcription and nucleotide excision repair as part of the TFIIH complex. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273169 [Multi-domain]  Cd Length: 705  Bit Score: 460.34  E-value: 1.29e-149
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217287858 240 TKIYYCSRTHSQLAQFVHEVKK--SPFGK------DVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSRHEKKkg 311
Cdd:TIGR00604  61 RKIIYASRTHSQLEQATEELRKlmSYRTPrigeesPVSGLSLASRKNLCLHPEVSKERQGKVVNGKCIKLTVSKIKEQ-- 138
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217287858 312 aeeekpkRRRQEKQAACPFY-NHEQMGLLRDEALAEVKDMEQLLALGKEARACPYYGSRLAIPAAQLVVLPYQMLLHAAT 390
Cdd:TIGR00604 139 -------RTEKPNVESCEFYeNFDELREVEDLLLSEIMDIEDLVEYGELLGLCPYFATRKMLPFANIVLLPYQYLLDPKI 211
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217287858 391 RQAAGIRLQDQVVIIDEAHNLIDTITGMHSVEVSGSQLCQAHSQLLQYVERYGKRLKAKNLMYLKQILYLLEKFVAVlgg 470
Cdd:TIGR00604 212 RSAVSIELKDSIVIFDEAHNLDNVCISSLSSNLSVRSLKRCSKEIAEYFEKIEERKEVDARKLLDELQKLVEGLKQE--- 288
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217287858 471 NIKQNPNTQSLSQTGTELKTINDFLFQSQIDNINLFKVQRYCEKSMISRKLFGFTERYGAVFSSR--EQPKLAGFQQFLQ 548
Cdd:TIGR00604 289 DLLTDEDIFLANPVLPKEVLPEAVPGNIRIAEIFLHKLSRYLEYLKDALKVLGVVSELPDAFLEHlkEKTFIDRPLRFCS 368
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217287858 549 SlqpRTTEAL--AAPADESQAStlrPASPLMHIQGFLAALTTANQDGRvILSRQGSLSQSTLKFLLLNPAVHFAQVVKEC 626
Cdd:TIGR00604 369 E---RLSNLLreLEITHPEDFS---ALVLLFTFATLVLTYTNGFLEGI-EPYENKTVPNPILKFMCLDPSIALKPLFERV 441
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217287858 627 RAVVIAGGTMQPAAGAVETplllhsvapgshvsqrklfcgfklkeknhdstfkrcltsgsscwpvpgwklsawwsfpvcl 706
Cdd:TIGR00604 442 RSVILASGTLSPLDAFPRN------------------------------------------------------------- 460
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217287858 707 aahlhLQFSAPPWLLPGHVIPPDNILPLVICSGISNQPLEFTFQKRELPQMMDEVGRILCNLCGVVPGGVVCFFPSYEYL 786
Cdd:TIGR00604 461 -----LGFNPVSQDSPTHILKRENLLTLIVTRGSDQVPLSSTFEIRNDPSLVRNLGELLVEFSKIIPDGIVVFFPSYSYL 535
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217287858 787 RQVHAHWEKGGLLGRLAARKKIFQEPKSAHQVEQVLLAYSrciQACGQERgqvtGALLLSVVGGKMSEGINFSDNLGRCV 866
Cdd:TIGR00604 536 ENIVSTWKEMGILENIEKKKLIFVETKDAQETSDALERYK---QAVSEGR----GAVLLSVAGGKVSEGIDFCDDLGRAV 608
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217287858 867 VMVGMPFPNIRSAELQEKMAYLDQTLPRAPGQappgkALVENLCMKAVNQSIGRAIRHQKDFASVVLLDQRYARPPVLAK 946
Cdd:TIGR00604 609 IMVGIPYEYTESRILLARLEFLRDQYPIRENQ-----DFYEFDAMRAVNQAIGRVIRHKDDYGSIVLLDKRYARSNKRKK 683
                         730       740
                  ....*....|....*....|
gi 2217287858 947 LPAWIRARVEVKATFGPAIA 966
Cdd:TIGR00604 684 LPKWIQDTIQSSDLNGMAIS 703
DEXDc2 smart00488
DEAD-like helicases superfamily;
24-450 6.13e-103

DEAD-like helicases superfamily;


Pssm-ID: 214693 [Multi-domain]  Cd Length: 289  Bit Score: 323.18  E-value: 6.13e-103
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217287858   24 IHFPFPFTPYSIQEDFMAELYRVLEAGKIGIFESPTGTGKSLSLICGALSWLRDFEQKKreeearlletgtgplhdekde 103
Cdd:smart00488   1 LLFYFPYEPYPIQYEFMEELKRVLDRGKIGILESPTGTGKTLSLLCLTLTWLRSFPERI--------------------- 59
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217287858  104 slclssscegaagtprPAGEPAWVTQFVqkkeerdlvdrlkaeqarrKQREERLQQLQHRVQLKyaakrlrqeeeerenl 183
Cdd:smart00488  60 ----------------QKIKLIYLSRTV-------------------SEIEKRLEELRKLMQKV---------------- 88
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217287858  184 lrlsremletgpeaerleqlesgeeelvlaEYESDEEkkvasrvdededdleeehitkiyycsrtHSQLAQFVHEVKKsp 263
Cdd:smart00488  89 ------------------------------EYESDEE----------------------------SEKQAQLLHELGR-- 108
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217287858  264 FGKDVRLVSLGSRQNLCVNEDVKSLGSVQLIND-RCVDMQRSRHEKKkgaeeekpkRRRQEKQAACPFYNHEQMGLLRDE 342
Cdd:smart00488 109 EKPKVLGLSLTSRKNLCLNPEVRTLKQNGLVVDeVCRSLTASKARKY---------RYENPKVERCPFYENTEFLLVRDL 179
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217287858  343 ALAEVKDMEQLLALGKEARACPYYGSRLAIPAAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAHNLIDTITGMHSVE 422
Cdd:smart00488 180 LPAEVYDIEDLLELGKRLGGCPYFASRKAIEFANVVVLPYQYLLDPKIRQALSIELKDSIVIFDEAHNLDNVCISALSSE 259
                          410       420       430
                   ....*....|....*....|....*....|
gi 2217287858  423 VSGSQLCQAHSQLLQYVERYGK--RLKAKN 450
Cdd:smart00488 260 LSRRSLERAHKNIKKYFERIEKirENDAKR 289
DEAD_2 pfam06733
DEAD_2; This represents a conserved region within a number of RAD3-like DNA-binding helicases ...
244-428 4.74e-72

DEAD_2; This represents a conserved region within a number of RAD3-like DNA-binding helicases that are seemingly ubiquitous - members include proteins of eukaryotic, bacterial and archaeal origin. RAD3 is involved in nucleotide excision repair, and forms part of the transcription factor TFIIH in yeast.


Pssm-ID: 399602 [Multi-domain]  Cd Length: 168  Bit Score: 235.62  E-value: 4.74e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217287858 244 YCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSRHEkkkgaeeekpkrrrqe 323
Cdd:pfam06733   1 YCSRTHSQLEQVVKELRRLPYYKKIRGLILGSRKNLCINPEVLKLKKGNLVNERCRELVKSKAR---------------- 64
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217287858 324 kqAACPFY-NHEQMGLLRDEALAEVKDMEQLLALGKEARACPYYGSRLAIPAAQLVVLPYQMLLHAATRQAAGIRLQDQV 402
Cdd:pfam06733  65 --GSCPFYnNLEDLLKLRDLLGDEVMDIEDLVELGEKLGICPYYLSRELIPDADIIILPYNYLLDPKIRESLSINLKNSI 142
                         170       180
                  ....*....|....*....|....*.
gi 2217287858 403 VIIDEAHNLIDTITGMHSVEVSGSQL 428
Cdd:pfam06733 143 VIFDEAHNIEDVCIESASFSISRSQL 168
SF2_C_XPD cd18788
C-terminal helicase domain of xeroderma pigmentosum group D (XPD) family DEAD-like helicases; ...
729-938 1.87e-63

C-terminal helicase domain of xeroderma pigmentosum group D (XPD) family DEAD-like helicases; The xeroderma pigmentosum group D (XPD)-like family members are DEAD-box helicases belonging to superfamily (SF)2. This family includes DDX11 (also called ChlR1), a protein involved in maintaining chromosome transmission fidelity and genome stability, the TFIIH basal transcription factor complex XPD subunit, and FANCJ (also known as BRIP1), a DNA helicase required for the maintenance of chromosomal stability. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350175 [Multi-domain]  Cd Length: 159  Bit Score: 211.31  E-value: 1.87e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217287858 729 DNILPLVICSGISNQPLEFTFQKRELPQMMDEVGRILCNLCGVVPGGVVCFFPSYEYLRQVHAhwekggllgrlaarkki 808
Cdd:cd18788     1 DQVCPGIVGRGPDQQALNSKFQTREDEAVMDELGNLLLELCAVVPDGVLVFFPSYSYMERVVS----------------- 63
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217287858 809 fqepksahqveqvllaysrciqacgqergqvTGALLLSVVGGKMSEGINFSDNLGRCVVMVGMPFPNIRSAELQEKMAYL 888
Cdd:cd18788    64 -------------------------------RGALLLAVCRGKVSEGIDFSDDLGRAVIMVGIPYPNTKDPILKLKMDDL 112
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 2217287858 889 DqtLPRAPGQaPPGKALVENLCMKAVNQSIGRAIRHQKDFASVVLLDQRY 938
Cdd:cd18788   113 E--YLRDKGL-LTGEDWYTFQAMRAVNQAIGRAIRHKNDYGAIVLLDKRF 159
Helicase_C_2 pfam13307
Helicase C-terminal domain; This domain is found at the C-terminus of DEAD-box helicases.
767-952 5.19e-55

Helicase C-terminal domain; This domain is found at the C-terminus of DEAD-box helicases.


Pssm-ID: 463840 [Multi-domain]  Cd Length: 168  Bit Score: 188.15  E-value: 5.19e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217287858 767 NLCGVVPGGVVCFFPSYEYLRQVHAHWEKGGLlgrlAARKKIFQEPKSAhQVEQVLLAYSRCiqacgqergqVTGALLLS 846
Cdd:pfam13307   2 RLLKVIPGGVLVFFPSYSYLEKVAERLKESGL----EKGIEIFVQPGEG-SREKLLEEFKKK----------GKGAVLFG 66
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217287858 847 VVGGKMSEGINFSDNLGRCVVMVGMPFPNIRSAELQEKMAYLDQTLPRapgqapPGKALVENLCMKAVNQSIGRAIRHQK 926
Cdd:pfam13307  67 VCGGSFSEGIDFPGDLLRAVIIVGLPFPNPDDPVVEAKREYLDSKGGN------PFNEWYLPQAVRAVNQAIGRLIRHEN 140
                         170       180
                  ....*....|....*....|....*.
gi 2217287858 927 DFASVVLLDQRYARPPVLAKLPAWIR 952
Cdd:pfam13307 141 DYGAIVLLDSRFLTKRYGKLLPKWLP 166
HELICc2 smart00491
helicase superfamily c-terminal domain;
783-940 2.39e-54

helicase superfamily c-terminal domain;


Pssm-ID: 214694 [Multi-domain]  Cd Length: 142  Bit Score: 185.18  E-value: 2.39e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217287858  783 YEYLRQVHAHWEKgglLGRLAARKKIFQEPKSAHQVEQVLLAYSRCIQACGqergqvtgALLLSVVGGKMSEGINFSDNL 862
Cdd:smart00491   1 YRYLEQVVEYWKE---NGILEINKPVFIEGKDSGETEELLEKYSAACEARG--------ALLLAVARGKVSEGIDFPDDL 69
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2217287858  863 GRCVVMVGMPFPNIRSAELQEKMAYLDQTlprapGQAPPGKALVENLCMKAVNQSIGRAIRHQKDFASVVLLDQRYAR 940
Cdd:smart00491  70 GRAVIIVGIPFPNPDSPILRARLEYLDEK-----GGIRPFDEVYLFDAMRALAQAIGRAIRHKNDYGVVVLLDKRYAR 142
DEAHc_DDX11_starthere cd17968
DEAH-box helicase domain of ATP-dependent DNA helicase DDX11; DDX11 (also called ChlR1) ...
239-412 5.00e-34

DEAH-box helicase domain of ATP-dependent DNA helicase DDX11; DDX11 (also called ChlR1) encodes a protein of the conserved family of Iron-Sulfur (Fe-S) cluster DNA helicases and is thought to function in maintaining chromosome transmission fidelity and genome stability. Mutations in the Chl1 human homologs ChlR1/DDX11 and BACH1/BRIP1/FANCJ collectively result in Warsaw Breakage Syndrome, Fanconi anemia, cell aneuploidy and breast and ovarian cancers. DDX11 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350726  Cd Length: 134  Bit Score: 127.05  E-value: 5.00e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217287858 239 ITKIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQnlcvnedvkslgsvqlindrcvdmqrsrhekkkgaeeekpk 318
Cdd:cd17968    26 LTKIYYCSRTHSQLAQFVHEVQKSPFGKDVRLVSLGSRQ----------------------------------------- 64
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217287858 319 rrrqekqaacpfynheqmgllrdealaevkdmeqllalgkearacpyygsrlaiPAAQLVVLPYQMLLHAATRQAAGIRL 398
Cdd:cd17968    65 ------------------------------------------------------PAAQVVVLPYQMLLHAATRKASGIKL 90
                         170
                  ....*....|....
gi 2217287858 399 QDQVVIIDEAHNLI 412
Cdd:cd17968    91 KDQVVIIDEAHNLI 104
DinG COG1199
Rad3-related DNA helicase DinG [Replication, recombination and repair];
360-961 2.21e-22

Rad3-related DNA helicase DinG [Replication, recombination and repair];


Pssm-ID: 440812 [Multi-domain]  Cd Length: 629  Bit Score: 103.08  E-value: 2.21e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217287858 360 ARACPYYGSRLAIPAAQLVVLPYQMLL-HAATRQAagIRLQDQVVIIDEAHNLIDTITGMHSVEVSGSQLcqahSQLLQY 438
Cdd:COG1199   173 YGVCPYELARRLAREADVVVVNHHLLFaDLALGEE--LLPEDDVLIIDEAHNLPDRARDMFSAELSSRSL----LRLLRE 246
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217287858 439 VERYGKRLKAKNLMY-LKQILYLLEKFVAVLGGNIKQNPNTQSLSQTGTELKTINDFLFQSqidninLFKVQRYCEKSMi 517
Cdd:COG1199   247 LRKLGLRPGLKKLLDlLERLREALDDLFLALEEEEELRLALGELPDEPEELLEALDALRDA------LEALAEALEEEL- 319
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217287858 518 srklfgfterygavfssREQPKLAGFQQFLQSLQPRTTEALAAPADEsqastlrpasplmhiqGFLAALTTANQDGRVIL 597
Cdd:COG1199   320 -----------------ERLAELDALLERLEELLFALARFLRIAEDE----------------GYVRWLEREGGDVRLHA 366
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217287858 598 SrqgslsqstlkflLLNPAVHFAQVV-KECRAVVIAGGTMqpaagAVETPLllhsvapgSHVSQRklfCGFKLK--EKNH 674
Cdd:COG1199   367 A-------------PLDPADLLRELLfSRARSVVLTSATL-----SVGGPF--------DYFARR---LGLDEDarTLSL 417
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217287858 675 DSTFkrcltsgsscwpvpgwklsawwsfpvclaahlhlqfsappwllpghviPPDNILPLVICSGISnQPleftfqkREL 754
Cdd:COG1199   418 PSPF------------------------------------------------DYENQALLYVPRDLP-RP-------SDR 441
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217287858 755 PQMMDEVGRILCNLCGVVPGGVVCFFPSYEYLRQVHAhwekggllgRLAARKKI---FQEPKSAHQveqvLLAYSRciqa 831
Cdd:COG1199   442 DGYLEAIAEAIAELLEASGGNTLVLFTSYRALEQVAE---------LLRERLDIpvlVQGDGSREA----LLERFR---- 504
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217287858 832 cgqERGqvtGALLLSvvGGKMSEGINFSDNLGRCVVMVGMPFPNIRSAELQEKMAYLDQ---------TLPRApgqappg 902
Cdd:COG1199   505 ---EGG---NSVLVG--TGSFWEGVDLPGDALSLVIIVKLPFPPPDDPVLEARREALEArggngfmyaYLPPA------- 569
                         570       580       590       600       610       620
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217287858 903 kalvenlcMKAVNQSIGRAIRHQKDFASVVLLDQRYARPPV----LAKLPAWIRARVEVKATF 961
Cdd:COG1199   570 --------VIKLKQGAGRLIRSEEDRGVVVLLDRRLLTKRYgkrfLDSLPPFRRTRPEELRAF 624
DEAHc_XPD-like cd17915
DEAH-box helicase domain of XPD family DEAD-like helicases; The xeroderma pigmentosum group D ...
238-412 1.96e-21

DEAH-box helicase domain of XPD family DEAD-like helicases; The xeroderma pigmentosum group D (XPD)-like family members are DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350673 [Multi-domain]  Cd Length: 138  Bit Score: 91.34  E-value: 1.96e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217287858 238 HITKIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRqnlcvnedvkslgsvqlindrcvdmqrsrhekkkgaeeekp 317
Cdd:cd17915    30 HKTKVLYCSRTHSQIEQIIRELRKLLEKRKIRALALSSR----------------------------------------- 68
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217287858 318 krrrqekqaacpfynheqmgllrdealaevkdmeqllalgkearacpyygsrlaipAAQLVVLPYQMLLHAATRQAAGIR 397
Cdd:cd17915    69 --------------------------------------------------------DADIVVLPYPYLLDARIREFIGID 92
                         170
                  ....*....|....*
gi 2217287858 398 LQDQVVIIDEAHNLI 412
Cdd:cd17915    93 LREQVVIIDEAHNLD 107
DEAHc_FancJ cd17970
DEAH-box helicase domain of Fanconi anemia group J protein and similar proteins; Fanconi ...
239-411 2.33e-20

DEAH-box helicase domain of Fanconi anemia group J protein and similar proteins; Fanconi anemia group J protein (FACJ or FANCJ, also known as BRIP1) is a DNA helicase required for the maintenance of chromosomal stability. It plays a role in the repair of DNA double-strand breaks by homologous recombination dependent on its interaction with BRCA1. FANCJ belongs to the DEAD-box helicase family, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350728 [Multi-domain]  Cd Length: 181  Bit Score: 89.71  E-value: 2.33e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217287858 239 ITKIYYCSRTHSQLAQFVHEVKKSPFgKDVRLVSLGSRQNLCVNEDVKSLGSvqlindrcvdmqrsrhekkkgaeeekpk 318
Cdd:cd17970    46 IPKIIYASRTHSQLAQVVRELKRTAY-KRPRMTILGSRDHLCIHPVINKLSN---------------------------- 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217287858 319 rrrQEKQAACpfynheqMGLLRDEALAEvkdmeqllalgkearacpyygsrlaipaaqLVVLPYQMLLHAATRQAAGIRL 398
Cdd:cd17970    97 ---QNANEAC-------MALLSGKNEAD------------------------------LVFCPYNYLLDPNIRRSMGLNL 136
                         170
                  ....*....|...
gi 2217287858 399 QDQVVIIDEAHNL 411
Cdd:cd17970   137 KGSVVIFDEAHNI 149
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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