|
Name |
Accession |
Description |
Interval |
E-value |
| A2M_2 |
cd02897 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy ... |
964-1270 |
2.69e-164 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production contributing to fetal survival. It has been suggested that thioester bond cleavage promotes the binding of PZ and alpha (2)-M to the CD91 receptor clearing them from circulation.
Pssm-ID: 239227 Cd Length: 292 Bit Score: 495.56 E-value: 2.69e-164
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580961 964 AMQNIQNLLQMPYGCGEQNMVLFAPNIYVLNYLNETQQLTQEIKAKAVGYLITGYQRQLNYKHQDGSYSTFGERYGrnQG 1043
Cdd:cd02897 1 ALQNLDNLLRMPYGCGEQNMVNFAPNIYVLDYLKATGQLTPEIESKALGFLRTGYQRQLTYKHSDGSYSAFGESDK--SG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580961 1044 NTWLTAFVLKTFAQARSYIFIDEAHITQSLTWLSQMQKDNGCFRSSGSLLNNAIKGGVEDEATLSAYVTIALLEIPLPVT 1123
Cdd:cd02897 79 STWLTAFVLKSFAQARPFIYIDENVLQQALTWLSSHQKSNGCFREVGRVFHKAMQGGVDDEVALTAYVLIALLEAGLPSE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580961 1124 NPIVRNALFCLESAWNVAkegthgSHVYTKALLAYAFSLLGkQNQNREILNSLDKEAVKEDNLVHWERPqrPKAPVGHLY 1203
Cdd:cd02897 159 RPVVEKALSCLEAALDSI------SDPYTLALAAYALTLAG-SEKRPEALKKLDELAISEDGTKHWSRP--PPSEEGPSY 229
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034580961 1204 QTQAPSAEVEMTSYVLLAYLTAQPAptsgDLTSATNIVKWIMKQQNAQGGFSSTQDTVVALHALSRY 1270
Cdd:cd02897 230 YWQAPSAEVEMTAYALLALLSAGGE----DLAEALPIVKWLAKQRNSLGGFSSTQDTVVALQALAKY 292
|
|
| TED_complement |
pfam07678 |
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement ... |
954-1270 |
1.20e-154 |
|
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement components such as C3, C4 and C5. This domain contains a short highly conserved region of proteinase-binding alpha-macro-globulins contains the cysteine and a glutamine of a thiol-ester bond that is cleaved at the moment of proteinase binding, and mediates the covalent binding of the alpha-macro-globulin to the proteinase. The GCGEQ motif is highly conserved.
Pssm-ID: 462227 [Multi-domain] Cd Length: 311 Bit Score: 471.01 E-value: 1.20e-154
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580961 954 FSVLGDILGSAMQ----NIQNLLQMPYGCGEQNMVLFAPNIYVLNYLNETQQLTQEIKAKAVGYLITGYQRQLNYKHQDG 1029
Cdd:pfam07678 1 ISVVGDIMGPAIQvvpeNLSSLLRLPYGCGEQNMVLFAPNVYVLRYLDKTNQLTKLIKSKAIDYLEQGYQRQLSYKHPDG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580961 1030 SYSTFGERygrnQGNTWLTAFVLKTFAQARSYIFIDEAHITQSLTWLSQMQKDNGCFRSSGSLLNNAIKGGVEDEATLSA 1109
Cdd:pfam07678 81 SYSAFGHS----PGSTWLTAFVLKVFAQARKFIFIDPEEICQSLRWLLSQQKPDGSFREPGPLLHRAMKGGVDGEVSLTA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580961 1110 YVTIALLEI-----PLPVTNPIVRNALFCLESawnvaKEGTHGSHVYTKALLAYAFSLLGKQNQNREILNSLDKEAVKED 1184
Cdd:pfam07678 157 YVTIALLEAldingLLQRVHPSIRKALTYLEQ-----AQLAGLTSPYTLAILAYALALAGSPETREELLKSLDAMAREEG 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580961 1185 NLVHWERPQRPKAPVGHLYQTQAPSAEVEMTSYVLLAYLtaqpapTSGDLTSATNIVKWIMKQQNAQGGFSSTQDTVVAL 1264
Cdd:pfam07678 232 NSRYWERDEKSDPQGVPEYPPQAPSLEVETTAYALLAYL------LLGDLTYADPIVKWLTSQRNSHGGFSSTQDTVVAL 305
|
....*.
gi 1034580961 1265 HALSRY 1270
Cdd:pfam07678 306 QALAEY 311
|
|
| YfaS |
COG2373 |
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ... |
128-1439 |
1.95e-49 |
|
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];
Pssm-ID: 441940 [Multi-domain] Cd Length: 1605 Bit Score: 193.76 E-value: 1.95e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580961 128 VFVQTDKPMYKPGQTVRFRVVSVDENFRPRNELiPLIY-LENPRRNRIAQwQSLKL-EAGINQLSFPLSSEPIQGSYRVV 205
Cdd:COG2373 371 AFLFTDRGIYRPGETVHLKALLRDADGKAPAGL-PLTLeLTDPDGKEVRR-QTLTLnEFGGYSFSFPLPEDAPTGTWRLE 448
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580961 206 VQTESGGRI-QHPFTVEEFVLPKFEVKVQVPKIISIMDEKVNITVCGEYTYGKPVPGL-ATVSLCRKLS----------- 272
Cdd:COG2373 449 LYVDPKPALgSKSFRVEEFKPPRFKVDLTLDKEPLKPGDPVTVTVDARYLFGAPAAGLkVEGEVTLRPArtafpgypgyr 528
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580961 273 --RVLNCDKQEVCEEFSQQLNSNGCITQQVHTKMLQitNTGFEMKLRVEARIREEGTDlEVTAnriSEITNIVSKLKFVK 350
Cdd:COG2373 529 fgDPDEEFEPEELDLGEGTLDADGKASLSLPLPDAP--DAPGPLRATVEASVFESGGR-PVTR---SATVPVHPADFYVG 602
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580961 351 V----DSHFRQGIPFFAQVLLVDGKGVPIPN-----KLF--------FISVNDANYYSNATTNEQgLAQFSINTTSISVN 413
Cdd:COG2373 603 IrlplFDGDPEGAPATFEVVAVDPDGKPVAGkglkvELYreewryvwYKSDDGGWRYESQEKEEP-VAEGTLTTGADGPA 681
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580961 414 KlfVRVFTVHPNlcfHYSWVAEDHQGaQHTANRVFSLSGSYIHLEPVAGTLpcghteTITahytLNRQ--AMGELSELSF 491
Cdd:COG2373 682 S--LSLTPVEWG---RYRLEVKDPDG-GLATSVRFYAGGNASWGAERPDRL------ELS----LDKEsyKPGETAKLLI 745
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580961 492 ------HYLIMakgvIVRSG---THTLPVEsgdmKGSFALSFPVESDVAP-------------------IARMFIFAILP 543
Cdd:COG2373 746 qspfagRALVT----VERDGvleTQWVDVK----GGGTTVEIPVTEDWAPnayvsatlvrpgdstandmPARAYGVAPLP 817
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580961 544 dgevVGDSEKfeienclANKVDLSfSPAQSPPASHAHLQV----AAAPQSLCALRAVDQSVLlmkpeaelsvssvynllt 619
Cdd:COG2373 818 ----VDPPAR-------RLKVELT-APEKLRPGETLTVTVkvkgAAGKAAEVTLAAVDEGIL------------------ 867
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580961 620 vkDLTNF--PDnvdqqeeeqghcPRPFFIHNGAIYVPLSsneaDIYSFLkgMGLKVFTNSKIRKpkscsvipsvsaGAVG 697
Cdd:COG2373 868 --NLTGYktPD------------PLDFFYGKRALGVETR----DLYGRL--IGAFGGAAGALRS------------GGDG 915
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580961 698 qgyyGAGLGVVERPyvpqlgtynviplnneqssgpvpetVRSYFPETWIWE-LVAVNSSGVAEVGVTVPDTITEWKAGAF 776
Cdd:COG2373 916 ----ALGRGGNPKP-------------------------PRKRFKPVALFSgPVKTDADGKATVSFDLPDFNGTLRVMAV 966
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580961 777 CLSEDAgLGiSSTASLRAFQPFFVELTMPYSVIRGEVFTLKATVLNYLPKCIRVSVQLKASPAFLASQNTKGEESycICG 856
Cdd:COG2373 967 AWSDDR-FG-SAEATVTVRKPLVVRPSLPRFLAPGDRFELPVDVFNLTGKAGTVTVTLEASGGLTLEGEATQTVT--LAA 1042
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580961 857 NERQTLSWTVTPKTLGNVNFSVSAEAmqslelcGNEvvevpeikrKDTVIKTLLVEAEGIEQEKTFSSMTcasGANVSEQ 936
Cdd:COG2373 1043 GGRATVRFPLKAPDAGDAKVTVTATG-------GGE---------SDAREVELPVRPANPLVTRATSGVL---APGESWT 1103
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580961 937 LSLKLPSNVVKESARASFSVLGDILGSAMQNIQNLLQMPYGCGEQNMVLFAPNIYVLNyLNETQQLTQEIKAKAVGYLIT 1016
Cdd:COG2373 1104 LPLDLPGGLRPGTGSLTLSLSSSPPLDLAGLLRYLLRYPYGCTEQTTSRALPLLYLSD-LAEALGLKGDKDAELRARIQA 1182
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580961 1017 GYQRQLNYKHQDGSYSTFGeryGRNQGNTWLTAFVLKTFAQARSY-IFIDEAHITQSLTWLSQMQKDNGcfrssgsllnn 1095
Cdd:COG2373 1183 AIARLLSMQNSDGGFGLWP---GGSESDPWLTAYATDFLLEAREAgYAVPDDALDRALDYLRNYLRNPW----------- 1248
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580961 1096 AIKGGVEDEATLSAYVTIALLEIPLPVTNPivrnalfcLESAWNVAKEGTHGshvYTKALLAYAFSLLGKQNQNREILNS 1175
Cdd:COG2373 1249 EIEYDDAYRLAVRAYALYVLARAGKADLGD--------LRYLYDRRKDALSP---LAKAQLAAALALLGDKARAEELLAA 1317
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580961 1176 LDKEAVKEDNLVHWerpqrpkapvGHLYQTqapsaEVEMTSYVLLAYLTAQPAPtsgdlTSATNIVKWIMKQQNaQGGFS 1255
Cdd:COG2373 1318 ALARLRETGARDYW----------YGDYGS-----PLRDQALALALLAELGPDA-----PLAPKLARWLAKALK-SGRWL 1376
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580961 1256 STQDTVVALHALSRYGAATFTRTEKTAQVTVQDsqtfsTNFQVDNNNLLLLQQISLPEL-PGEYVITVTGERCVYLQTSM 1334
Cdd:COG2373 1377 STQETAWALLALAAYARAAGASPDFTATLTLDG-----KTLPLTGRGPLARVTLPAAELlAGPLTITNTGDGPLYYTLTL 1451
|
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580961 1335 KYNILPEKE---DSPFALKVQ---TVPQTCDGHKAH--TSFQISLTISyTGNRPASNMVIVDvkMV-SGFIPLKP----- 1400
Cdd:COG2373 1452 SGYPAEGPPpaaSNGLEIERRyydLDGKPIDPASLKqgDLVVVRLTVT-APSGRVENVAVVD--PLpAGFEIENPrlats 1528
|
1370 1380 1390 1400
....*....|....*....|....*....|....*....|.
gi 1034580961 1401 --TVKMLERSSSVSRTEVSNNHVLIYVEQVTNQTLSFSFMV 1439
Cdd:COG2373 1529 gdLGDWLGDSWQPDHQEFRDDRVVAAFDLDPAGTYTFAYLV 1569
|
|
| A2M |
pfam00207 |
Alpha-2-macroglobulin family; This family includes the C-terminal region of the ... |
744-834 |
1.75e-40 |
|
Alpha-2-macroglobulin family; This family includes the C-terminal region of the alpha-2-macroglobulin family.
Pssm-ID: 459711 [Multi-domain] Cd Length: 91 Bit Score: 144.27 E-value: 1.75e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580961 744 TWIWELVAVNSSGVAEVGVTVPDTITEWKAGAFCLSEDAGLGISSTASLRAFQPFFVELTMPYSVIRGEVFTLKATVLNY 823
Cdd:pfam00207 1 TWLWDPVLVTDNGKASLSFTLPDSITTWRATAFALSPDTGLGVAEPPELVVFKPFFVDLNLPYSVRRGEQFELKATVFNY 80
|
90
....*....|.
gi 1034580961 824 LPKCIRVSVQL 834
Cdd:pfam00207 81 LDKCLKVRVRL 91
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| A2M_2 |
cd02897 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy ... |
964-1270 |
2.69e-164 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production contributing to fetal survival. It has been suggested that thioester bond cleavage promotes the binding of PZ and alpha (2)-M to the CD91 receptor clearing them from circulation.
Pssm-ID: 239227 Cd Length: 292 Bit Score: 495.56 E-value: 2.69e-164
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580961 964 AMQNIQNLLQMPYGCGEQNMVLFAPNIYVLNYLNETQQLTQEIKAKAVGYLITGYQRQLNYKHQDGSYSTFGERYGrnQG 1043
Cdd:cd02897 1 ALQNLDNLLRMPYGCGEQNMVNFAPNIYVLDYLKATGQLTPEIESKALGFLRTGYQRQLTYKHSDGSYSAFGESDK--SG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580961 1044 NTWLTAFVLKTFAQARSYIFIDEAHITQSLTWLSQMQKDNGCFRSSGSLLNNAIKGGVEDEATLSAYVTIALLEIPLPVT 1123
Cdd:cd02897 79 STWLTAFVLKSFAQARPFIYIDENVLQQALTWLSSHQKSNGCFREVGRVFHKAMQGGVDDEVALTAYVLIALLEAGLPSE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580961 1124 NPIVRNALFCLESAWNVAkegthgSHVYTKALLAYAFSLLGkQNQNREILNSLDKEAVKEDNLVHWERPqrPKAPVGHLY 1203
Cdd:cd02897 159 RPVVEKALSCLEAALDSI------SDPYTLALAAYALTLAG-SEKRPEALKKLDELAISEDGTKHWSRP--PPSEEGPSY 229
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034580961 1204 QTQAPSAEVEMTSYVLLAYLTAQPAptsgDLTSATNIVKWIMKQQNAQGGFSSTQDTVVALHALSRY 1270
Cdd:cd02897 230 YWQAPSAEVEMTAYALLALLSAGGE----DLAEALPIVKWLAKQRNSLGGFSSTQDTVVALQALAKY 292
|
|
| TED_complement |
pfam07678 |
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement ... |
954-1270 |
1.20e-154 |
|
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement components such as C3, C4 and C5. This domain contains a short highly conserved region of proteinase-binding alpha-macro-globulins contains the cysteine and a glutamine of a thiol-ester bond that is cleaved at the moment of proteinase binding, and mediates the covalent binding of the alpha-macro-globulin to the proteinase. The GCGEQ motif is highly conserved.
Pssm-ID: 462227 [Multi-domain] Cd Length: 311 Bit Score: 471.01 E-value: 1.20e-154
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580961 954 FSVLGDILGSAMQ----NIQNLLQMPYGCGEQNMVLFAPNIYVLNYLNETQQLTQEIKAKAVGYLITGYQRQLNYKHQDG 1029
Cdd:pfam07678 1 ISVVGDIMGPAIQvvpeNLSSLLRLPYGCGEQNMVLFAPNVYVLRYLDKTNQLTKLIKSKAIDYLEQGYQRQLSYKHPDG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580961 1030 SYSTFGERygrnQGNTWLTAFVLKTFAQARSYIFIDEAHITQSLTWLSQMQKDNGCFRSSGSLLNNAIKGGVEDEATLSA 1109
Cdd:pfam07678 81 SYSAFGHS----PGSTWLTAFVLKVFAQARKFIFIDPEEICQSLRWLLSQQKPDGSFREPGPLLHRAMKGGVDGEVSLTA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580961 1110 YVTIALLEI-----PLPVTNPIVRNALFCLESawnvaKEGTHGSHVYTKALLAYAFSLLGKQNQNREILNSLDKEAVKED 1184
Cdd:pfam07678 157 YVTIALLEAldingLLQRVHPSIRKALTYLEQ-----AQLAGLTSPYTLAILAYALALAGSPETREELLKSLDAMAREEG 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580961 1185 NLVHWERPQRPKAPVGHLYQTQAPSAEVEMTSYVLLAYLtaqpapTSGDLTSATNIVKWIMKQQNAQGGFSSTQDTVVAL 1264
Cdd:pfam07678 232 NSRYWERDEKSDPQGVPEYPPQAPSLEVETTAYALLAYL------LLGDLTYADPIVKWLTSQRNSHGGFSSTQDTVVAL 305
|
....*.
gi 1034580961 1265 HALSRY 1270
Cdd:pfam07678 306 QALAEY 311
|
|
| A2M_like |
cd02891 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier ... |
964-1270 |
3.00e-114 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. This group contains another broadly specific proteinase inhibitor: pregnancy zone protein (PZP). PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system. This group also contains C3, C4 and C5 of vertebrate complement. The vertebrate complement is an effector of both the acquired and innate immune systems The point of convergence of the classical, alternative and lectin pathways of the complement system is the proteolytic activation of C3. C4 plays a key role in propagating the classical and lectin pathways. C5 participates in the classical and alternative pathways. The thioester bond located within the structure of C3 and C4 is central to the function of complement. C5 does not contain an active thioester bond.
Pssm-ID: 239221 [Multi-domain] Cd Length: 282 Bit Score: 360.94 E-value: 3.00e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580961 964 AMQNIQNLLQMPYGCGEQNMVLFAPNIYVLNYLNETQQLTQEIKAKAVGYLITGYQRQLNYKHQDGSYSTFGeryGRNQG 1043
Cdd:cd02891 1 SLGNLDYLLRYPYGCGEQTMSRAAPNLYVLKYLDATGQLTPEIREKALEYIRKGYQRLLTYQRSDGSFSAWG---NSDSG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580961 1044 NTWLTAFVLKTFAQARSYIFIDEAHITQSLTWLSQMQKDNGCFRSSGSLLNNAIKGGVEDEATLSAYVTIALLEIPLPVT 1123
Cdd:cd02891 78 STWLTAYVVKFLSQARKYIDVDENVLARALGWLVPQQKEDGSFRELGPVIHREMKGGVDDSVSLTAYVLIALAEAGKACD 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580961 1124 NPIvRNALFCLESAWNVAKegthgsHVYTKALLAYAFSLLGKQNQNREILNSLDKEAVKEDNLVHWERpqrpkapvgHLY 1203
Cdd:cd02891 158 ASI-EKALAYLETQLDGLL------DPYALAILAYALALAGDSTRADEALKKLLEAAREKGGTAHWSL---------SWP 221
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034580961 1204 QTQAPSAEVEMTSYVLLAYLTAqpaptsGDLTSATNIVKWIMKQQNAQGGFSSTQDTVVALHALSRY 1270
Cdd:cd02891 222 GDYGSSLRVEATAYALLALLKL------GDLEEAGPIAKWLAQQRNSGGGFLSTQDTVVALQALAAY 282
|
|
| complement_C3_C4_C5 |
cd02896 |
Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, ... |
967-1270 |
1.64e-77 |
|
Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the classical, alternative and lectin pathways of the complement system is the proteolytic activation of C3. C4 plays a key role in propagating the classical and lectin pathways. C5 participates in the classical and alternative pathways. The thioester bond located within the structure of C3 and C4 is central to the function of complement. C5 does not contain an active thioester bond.
Pssm-ID: 239226 [Multi-domain] Cd Length: 297 Bit Score: 258.74 E-value: 1.64e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580961 967 NIQNLLQMPYGCGEQNMVLFAPNIYVLNYLNETQQLTQ---EIKAKAVGYLITGYQRQLNYKHQDGSYSTFGERygrnQG 1043
Cdd:cd02896 4 GLEKLIRLPTGCGEQTMIKLAPTVYALRYLDTTNQWEKlgpERRDEALKYIRQGYQRQLSYRKPDGSYAAWKNR----PS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580961 1044 NTWLTAFVLKTFAQARSYIFIDEAHITQSLTWLSQMQKDNGCFRSSGSLLNNAIKGGV---EDEATLSAYVTIALLEIpL 1120
Cdd:cd02896 80 STWLTAFVVKVFSLARKYIPVDQNVICGSVNWLISNQKPDGSFQEPSPVIHREMTGGVegsEGDVSLTAFVLIALQEA-R 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580961 1121 PVTNPIVRNalfcLESAWNVAKE-----GTHGSHVYTKALLAYAFSLLGKqNQNREILNSLDKEAVKEDNLVHWERPQRP 1195
Cdd:cd02896 159 SICPPEVQN----LDQSIRKAISylenqLPNLQRPYALAITAYALALADS-PLSHAANRKLLSLAKRDGNGWYWWTIDSP 233
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034580961 1196 kapvgHLYQTQAPSAEVEMTSYVLLAYLtaqpapTSGDLTSATNIVKWIMKQQNAQGGFSSTQDTVVALHALSRY 1270
Cdd:cd02896 234 -----YWPVPGPSAITVETTAYALLALL------KLGDIEYANPIARWLTEQRNYGGGFGSTQDTVVALQALAEY 297
|
|
| ISOPREN_C2_like |
cd00688 |
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two ... |
964-1270 |
8.94e-69 |
|
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate complement. Class II terpene cyclases include squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY), these integral membrane proteins catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. The protein prenyltransferases include protein farnesyltransferase (FTase) and geranylgeranyltransferase types I and II (GGTase-I and GGTase-II) which catalyze the carboxyl-terminal lipidation of Ras, Rab, and several other cellular signal transduction proteins, facilitating membrane associations and specific protein-protein interactions. Alpha (2)-M is a major carrier protein in serum and involved in the immobilization and entrapment of proteases. PZP is a pregnancy associated protein. Alpha (2)-M and PZP are known to bind to and, may modulate, the activity of placental protein-14 in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system.
Pssm-ID: 238362 [Multi-domain] Cd Length: 300 Bit Score: 233.98 E-value: 8.94e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580961 964 AMQNIQNLLQMPYG--------CGEQNMVLFAPNIYVLNYLNETqqltqEIKAKAVGYLITGYQRQLNYKHQDGSYSTFG 1035
Cdd:cd00688 1 IEKHLKYLLRYPYGdghwyqslCGEQTWSTAWPLLALLLLLAAT-----GIRDKADENIEKGIQRLLSYQLSDGGFSGWG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580961 1036 eryGRNQGNTWLTAFVLKTFAQARSYIFIDEAHITQSLTWLSQMQKDNGCFRSSGSLLNNaiKGGVEDEATLSAYVTIAL 1115
Cdd:cd00688 76 ---GNDYPSLWLTAYALKALLLAGDYIAVDRIDLARALNWLLSLQNEDGGFREDGPGNHR--IGGDESDVRLTAYALIAL 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580961 1116 LEIPLPVTNPIVRNALFCLESAWNvaKEGTHG----SHVYTKALLAYAFSLLGKQNQN--REILNSLDKEAVKEDNLVHW 1189
Cdd:cd00688 151 ALLGKLDPDPLIEKALDYLLSCQN--YDGGFGpggeSHGYGTACAAAALALLGDLDSPdaKKALRWLLSRQRPDGGWGEG 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580961 1190 ERpqrpkapvghLYQTQAPSAEVEMTSYVLLAYLTAqpaptsGDLTSATNIVKWIMKQQNAQGGFSS-------TQDTVV 1262
Cdd:cd00688 229 RD----------RTNKLSDSCYTEWAAYALLALGKL------GDLEDAEKLVKWLLSQQNEDGGFSSkpgksydTQHTVF 292
|
....*...
gi 1034580961 1263 ALHALSRY 1270
Cdd:cd00688 293 ALLALSLY 300
|
|
| YfaS |
COG2373 |
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ... |
128-1439 |
1.95e-49 |
|
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];
Pssm-ID: 441940 [Multi-domain] Cd Length: 1605 Bit Score: 193.76 E-value: 1.95e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580961 128 VFVQTDKPMYKPGQTVRFRVVSVDENFRPRNELiPLIY-LENPRRNRIAQwQSLKL-EAGINQLSFPLSSEPIQGSYRVV 205
Cdd:COG2373 371 AFLFTDRGIYRPGETVHLKALLRDADGKAPAGL-PLTLeLTDPDGKEVRR-QTLTLnEFGGYSFSFPLPEDAPTGTWRLE 448
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580961 206 VQTESGGRI-QHPFTVEEFVLPKFEVKVQVPKIISIMDEKVNITVCGEYTYGKPVPGL-ATVSLCRKLS----------- 272
Cdd:COG2373 449 LYVDPKPALgSKSFRVEEFKPPRFKVDLTLDKEPLKPGDPVTVTVDARYLFGAPAAGLkVEGEVTLRPArtafpgypgyr 528
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580961 273 --RVLNCDKQEVCEEFSQQLNSNGCITQQVHTKMLQitNTGFEMKLRVEARIREEGTDlEVTAnriSEITNIVSKLKFVK 350
Cdd:COG2373 529 fgDPDEEFEPEELDLGEGTLDADGKASLSLPLPDAP--DAPGPLRATVEASVFESGGR-PVTR---SATVPVHPADFYVG 602
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580961 351 V----DSHFRQGIPFFAQVLLVDGKGVPIPN-----KLF--------FISVNDANYYSNATTNEQgLAQFSINTTSISVN 413
Cdd:COG2373 603 IrlplFDGDPEGAPATFEVVAVDPDGKPVAGkglkvELYreewryvwYKSDDGGWRYESQEKEEP-VAEGTLTTGADGPA 681
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580961 414 KlfVRVFTVHPNlcfHYSWVAEDHQGaQHTANRVFSLSGSYIHLEPVAGTLpcghteTITahytLNRQ--AMGELSELSF 491
Cdd:COG2373 682 S--LSLTPVEWG---RYRLEVKDPDG-GLATSVRFYAGGNASWGAERPDRL------ELS----LDKEsyKPGETAKLLI 745
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580961 492 ------HYLIMakgvIVRSG---THTLPVEsgdmKGSFALSFPVESDVAP-------------------IARMFIFAILP 543
Cdd:COG2373 746 qspfagRALVT----VERDGvleTQWVDVK----GGGTTVEIPVTEDWAPnayvsatlvrpgdstandmPARAYGVAPLP 817
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580961 544 dgevVGDSEKfeienclANKVDLSfSPAQSPPASHAHLQV----AAAPQSLCALRAVDQSVLlmkpeaelsvssvynllt 619
Cdd:COG2373 818 ----VDPPAR-------RLKVELT-APEKLRPGETLTVTVkvkgAAGKAAEVTLAAVDEGIL------------------ 867
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580961 620 vkDLTNF--PDnvdqqeeeqghcPRPFFIHNGAIYVPLSsneaDIYSFLkgMGLKVFTNSKIRKpkscsvipsvsaGAVG 697
Cdd:COG2373 868 --NLTGYktPD------------PLDFFYGKRALGVETR----DLYGRL--IGAFGGAAGALRS------------GGDG 915
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580961 698 qgyyGAGLGVVERPyvpqlgtynviplnneqssgpvpetVRSYFPETWIWE-LVAVNSSGVAEVGVTVPDTITEWKAGAF 776
Cdd:COG2373 916 ----ALGRGGNPKP-------------------------PRKRFKPVALFSgPVKTDADGKATVSFDLPDFNGTLRVMAV 966
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580961 777 CLSEDAgLGiSSTASLRAFQPFFVELTMPYSVIRGEVFTLKATVLNYLPKCIRVSVQLKASPAFLASQNTKGEESycICG 856
Cdd:COG2373 967 AWSDDR-FG-SAEATVTVRKPLVVRPSLPRFLAPGDRFELPVDVFNLTGKAGTVTVTLEASGGLTLEGEATQTVT--LAA 1042
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580961 857 NERQTLSWTVTPKTLGNVNFSVSAEAmqslelcGNEvvevpeikrKDTVIKTLLVEAEGIEQEKTFSSMTcasGANVSEQ 936
Cdd:COG2373 1043 GGRATVRFPLKAPDAGDAKVTVTATG-------GGE---------SDAREVELPVRPANPLVTRATSGVL---APGESWT 1103
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580961 937 LSLKLPSNVVKESARASFSVLGDILGSAMQNIQNLLQMPYGCGEQNMVLFAPNIYVLNyLNETQQLTQEIKAKAVGYLIT 1016
Cdd:COG2373 1104 LPLDLPGGLRPGTGSLTLSLSSSPPLDLAGLLRYLLRYPYGCTEQTTSRALPLLYLSD-LAEALGLKGDKDAELRARIQA 1182
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580961 1017 GYQRQLNYKHQDGSYSTFGeryGRNQGNTWLTAFVLKTFAQARSY-IFIDEAHITQSLTWLSQMQKDNGcfrssgsllnn 1095
Cdd:COG2373 1183 AIARLLSMQNSDGGFGLWP---GGSESDPWLTAYATDFLLEAREAgYAVPDDALDRALDYLRNYLRNPW----------- 1248
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580961 1096 AIKGGVEDEATLSAYVTIALLEIPLPVTNPivrnalfcLESAWNVAKEGTHGshvYTKALLAYAFSLLGKQNQNREILNS 1175
Cdd:COG2373 1249 EIEYDDAYRLAVRAYALYVLARAGKADLGD--------LRYLYDRRKDALSP---LAKAQLAAALALLGDKARAEELLAA 1317
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580961 1176 LDKEAVKEDNLVHWerpqrpkapvGHLYQTqapsaEVEMTSYVLLAYLTAQPAPtsgdlTSATNIVKWIMKQQNaQGGFS 1255
Cdd:COG2373 1318 ALARLRETGARDYW----------YGDYGS-----PLRDQALALALLAELGPDA-----PLAPKLARWLAKALK-SGRWL 1376
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580961 1256 STQDTVVALHALSRYGAATFTRTEKTAQVTVQDsqtfsTNFQVDNNNLLLLQQISLPEL-PGEYVITVTGERCVYLQTSM 1334
Cdd:COG2373 1377 STQETAWALLALAAYARAAGASPDFTATLTLDG-----KTLPLTGRGPLARVTLPAAELlAGPLTITNTGDGPLYYTLTL 1451
|
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580961 1335 KYNILPEKE---DSPFALKVQ---TVPQTCDGHKAH--TSFQISLTISyTGNRPASNMVIVDvkMV-SGFIPLKP----- 1400
Cdd:COG2373 1452 SGYPAEGPPpaaSNGLEIERRyydLDGKPIDPASLKqgDLVVVRLTVT-APSGRVENVAVVD--PLpAGFEIENPrlats 1528
|
1370 1380 1390 1400
....*....|....*....|....*....|....*....|.
gi 1034580961 1401 --TVKMLERSSSVSRTEVSNNHVLIYVEQVTNQTLSFSFMV 1439
Cdd:COG2373 1529 gdLGDWLGDSWQPDHQEFRDDRVVAAFDLDPAGTYTFAYLV 1569
|
|
| A2M |
pfam00207 |
Alpha-2-macroglobulin family; This family includes the C-terminal region of the ... |
744-834 |
1.75e-40 |
|
Alpha-2-macroglobulin family; This family includes the C-terminal region of the alpha-2-macroglobulin family.
Pssm-ID: 459711 [Multi-domain] Cd Length: 91 Bit Score: 144.27 E-value: 1.75e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580961 744 TWIWELVAVNSSGVAEVGVTVPDTITEWKAGAFCLSEDAGLGISSTASLRAFQPFFVELTMPYSVIRGEVFTLKATVLNY 823
Cdd:pfam00207 1 TWLWDPVLVTDNGKASLSFTLPDSITTWRATAFALSPDTGLGVAEPPELVVFKPFFVDLNLPYSVRRGEQFELKATVFNY 80
|
90
....*....|.
gi 1034580961 824 LPKCIRVSVQL 834
Cdd:pfam00207 81 LDKCLKVRVRL 91
|
|
| A2M_recep |
pfam07677 |
A-macroglobulin receptor binding domain; This family includes the receptor binding domain ... |
1380-1469 |
2.47e-33 |
|
A-macroglobulin receptor binding domain; This family includes the receptor binding domain region of the alpha-2-macroglobulin family.
Pssm-ID: 462226 Cd Length: 92 Bit Score: 123.83 E-value: 2.47e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580961 1380 PASNMVIVDVKMVSGFIPLKPTVKMLERSSSVSRTE-VSNNHVLIYVEQVTNQTLSFSFMVLQDIPVGDLKPAIVKVYDY 1458
Cdd:pfam07677 1 ESSNMAILEVGLPSGFVPDEEDLKKLGVDPLIKRVEtVDDGKVILYLDKLSGEPLCFSFRAEQTFPVANLKPAPVKVYDY 80
|
90
....*....|.
gi 1034580961 1459 YETDESVVAEY 1469
Cdd:pfam07677 81 YEPERRATTFY 91
|
|
| A2M_BRD |
pfam07703 |
Alpha-2-macroglobulin bait region domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins ... |
455-603 |
4.15e-31 |
|
Alpha-2-macroglobulin bait region domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain encompasses macroglobulin-like domain MG5 and 6 including bait region. In Salmonella enterica ser A2Ms, this domain encompasses MG7 and MG8 including the bait region. The Bait region is cleaved by proteases, followed by a large conformational change that blocks the target protease within a cage-like complex. This model of protease entrapment is recognized as the Venus flytrap mechanism.
Pssm-ID: 462235 [Multi-domain] Cd Length: 139 Bit Score: 119.38 E-value: 4.15e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580961 455 IHLEPVAGTLPCGHTETITAHYTLNRQAMGElselSFHYLIMAKGVIVRSGthtlpvesgDMKGSFALSFPVESDVAPIA 534
Cdd:pfam07703 1 LHLSTDKTEYKPGETATVTVKSPFDGTVERD----GFTYLVLSKGQIVVVG---------RGGVTTSFSLPVTAEMAPSA 67
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034580961 535 RMFIFAI---LPDGEVVGDSEKFEIENCLANKVDLSFSPAQSPPASHAHLQVAAAPQSLCALRAVDQSVLLM 603
Cdd:pfam07703 68 RVVAYYVrvdLSKPEVVADSVWVDVDDTCENKLKVTLSAEKYRPGSTVELKVKADPGAYVALAAVDKGVLLL 139
|
|
| MG4 |
pfam17789 |
Macroglobulin domain MG4; This domain is MG4 found in complement C3 and C5 proteins. |
346-441 |
1.87e-29 |
|
Macroglobulin domain MG4; This domain is MG4 found in complement C3 and C5 proteins.
Pssm-ID: 465507 Cd Length: 95 Bit Score: 113.11 E-value: 1.87e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580961 346 LKFVKVDSHFRQGIPFFAQVLLVDGKGVPIPNKLFFISVNDANYYSNATTNEQGLAQFSINTTSiSVNKLFVRVFTVHPN 425
Cdd:pfam17789 1 ITFEKTPKYFKPGLPFSGQVLVVDPDGSPAPNVPVFIEAGNTEFNQNLTTDEDGTAQFSINTPG-NAASLSITVKTKDPD 79
|
90
....*....|....*.
gi 1034580961 426 LCFHYSWVAEDHQGAQ 441
Cdd:pfam17789 80 LCPEHQALAEMYAEAY 95
|
|
| MG3 |
pfam17791 |
Macroglobulin domain MG3; This entry corresponds to the MG3 domain found in complement ... |
222-309 |
4.38e-28 |
|
Macroglobulin domain MG3; This entry corresponds to the MG3 domain found in complement components C3, C4 and C5.
Pssm-ID: 465509 Cd Length: 83 Bit Score: 108.90 E-value: 4.38e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580961 222 EFVLPKFEVKVQVPKIISIMDEKVNITVCGEYTYGKPVPGLATVSLCRKLSrvlncDKQEVCEEFSQQLNSNGCITQQVH 301
Cdd:pfam17791 1 EYVLPKFEVKVEVPKFISVKDEEFQVTICAKYTYGKPVKGKAYVTLCLKDD-----SKRKCFESFSKELDKDGCGSASLS 75
|
....*...
gi 1034580961 302 TKMLQITN 309
Cdd:pfam17791 76 TEEFQLTF 83
|
|
| MG2 |
pfam01835 |
MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. ... |
128-220 |
7.55e-25 |
|
MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain is termed macroglobulin-like (MG) domain 2 and in Salmonella enterica ser A2Ms, this is domain 4.
Pssm-ID: 426464 [Multi-domain] Cd Length: 95 Bit Score: 100.08 E-value: 7.55e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580961 128 VFVQTDKPMYKPGQTVRFRVVSVDENFRPRNELIPLIYLENPRRNRIAQWQSLKLEAGINQLSFPLSSEPIQGSYRVVVQ 207
Cdd:pfam01835 2 AFVYTDRGIYRPGETVHFKGLLRDQDLRPLAGLPVTLTVTDPDGNEVRRLPLTTDEFGGFSGSFPLPETAPTGTYTVVLR 81
|
90
....*....|....
gi 1034580961 208 TESGGRI-QHPFTV 220
Cdd:pfam01835 82 DGAGGSLgSGSFRV 95
|
|
| YfaS |
COG2373 |
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ... |
122-196 |
9.12e-03 |
|
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];
Pssm-ID: 441940 [Multi-domain] Cd Length: 1605 Bit Score: 40.83 E-value: 9.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580961 122 LNTQSLVFVQTDKPMYKPGQTVRFRVVSvdenfrprneliP-----LIYLEnprRNRIAQWQSLKLEAGINQLSFPLSSE 196
Cdd:COG2373 720 AERPDRLELSLDKESYKPGETAKLLIQS------------PfagraLVTVE---RDGVLETQWVDVKGGGTTVEIPVTED 784
|
|
| |
