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Conserved domains on  [gi|1039733661|ref|XP_017169511|]
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zinc finger protein 873 isoform X4 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016931)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

CATH:  3.30.160.60|1.10.287.1360
Gene Ontology:  GO:0005515|GO:0008270|GO:0003677|GO:0006355|GO:0001217|GO:0003700
PubMed:  8183940|22803940|2023909|8183939|10748030|27867147|28765213|11361095|30718982|10940247
SCOP:  4003583|4002243

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 4-44 3.21e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 80.98  E-value: 3.21e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1039733661   4 VTYEDVHVNFTHEEWALLDSSQKSLYKDVMLETCRNLTAIG 44
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
81-453 1.15e-10

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.95  E-value: 1.15e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039733661  81 KKQCSFACNSFLQMYERIYNEEKAYECNQYS--KAFVNFHSLPQHAKNHPREQPYECNHCGKAYV--------------- 143
Cdd:COG5048    38 NCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGcdKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNskasssslsssssns 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039733661 144 -----SPSSQIHKRSHVGEKPYECSKCgKAFENDNHLQNREKHHTLEKLFECSQC-----GKAFASRSYLPIHRRIHTGE 213
Cdd:COG5048   118 ndnnlLSSHSLPPSSRDPQLPDLLSIS-NLRNNPLPGNNSSSVNTPQSNSLHPPLpanslSKDPSSNLSLLISSNVSTSI 196

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039733661 214 KPYECTQCGKAFTSRSYLKIHKSVHTGEKPYECNQCSKAF------ANFYSLRQHEKYHTREKPYECSHCSKAFPSPSSL 287
Cdd:COG5048   197 PSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPN 276

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039733661 288 QVHERTHTG-EKPYDCTECGKAFISHSSLQIHKR--VHTGE--KPYECT--LCGKAFVNRSYLEVHKRIHTGEKPYEC-- 358
Cdd:COG5048   277 ESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKEkl 356

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039733661 359 SQCSKAF-----ANFRSLRQHEKNHTREKPYEC--SQCSKAFVSPCHLQIHQRTHTGEKP--YDCSDCGKAFTRLSNLQV 429
Cdd:COG5048   357 LNSSSKFspllnNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIP 436

                         410       420
                  ....*....|....*....|....
gi 1039733661 430 HKRTHTGQKPYCCSQCGKAFPCFS 453
Cdd:COG5048   437 HKKIHTNHAPLLCSILKSFRRDLD 460
zf-H2C2_2 pfam13465
Zinc-finger double domain;
454-479 8.38e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 8.38e-04
                          10        20
                  ....*....|....*....|....*.
gi 1039733661 454 NLQIHERTHTGEKPYACNQCGKAFAS 479
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
511-535 1.07e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.07e-03
                          10        20
                  ....*....|....*....|....*
gi 1039733661 511 LQVHERTHTGEKPHQCTQCGKAFVS 535
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 4-44 3.21e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 80.98  E-value: 3.21e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1039733661   4 VTYEDVHVNFTHEEWALLDSSQKSLYKDVMLETCRNLTAIG 44
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
4-45 3.85e-17

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 75.71  E-value: 3.85e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1039733661    4 VTYEDVHVNFTHEEWALLDSSQKSLYKDVMLETCRNLTAIGY 45
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGF 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-41 4.59e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 74.89  E-value: 4.59e-17
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1039733661   4 VTYEDVHVNFTHEEWALLDSSQKSLYKDVMLETCRNLT 41
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
81-453 1.15e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.95  E-value: 1.15e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039733661  81 KKQCSFACNSFLQMYERIYNEEKAYECNQYS--KAFVNFHSLPQHAKNHPREQPYECNHCGKAYV--------------- 143
Cdd:COG5048    38 NCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGcdKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNskasssslsssssns 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039733661 144 -----SPSSQIHKRSHVGEKPYECSKCgKAFENDNHLQNREKHHTLEKLFECSQC-----GKAFASRSYLPIHRRIHTGE 213
Cdd:COG5048   118 ndnnlLSSHSLPPSSRDPQLPDLLSIS-NLRNNPLPGNNSSSVNTPQSNSLHPPLpanslSKDPSSNLSLLISSNVSTSI 196

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039733661 214 KPYECTQCGKAFTSRSYLKIHKSVHTGEKPYECNQCSKAF------ANFYSLRQHEKYHTREKPYECSHCSKAFPSPSSL 287
Cdd:COG5048   197 PSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPN 276

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039733661 288 QVHERTHTG-EKPYDCTECGKAFISHSSLQIHKR--VHTGE--KPYECT--LCGKAFVNRSYLEVHKRIHTGEKPYEC-- 358
Cdd:COG5048   277 ESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKEkl 356

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039733661 359 SQCSKAF-----ANFRSLRQHEKNHTREKPYEC--SQCSKAFVSPCHLQIHQRTHTGEKP--YDCSDCGKAFTRLSNLQV 429
Cdd:COG5048   357 LNSSSKFspllnNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIP 436

                         410       420
                  ....*....|....*....|....
gi 1039733661 430 HKRTHTGQKPYCCSQCGKAFPCFS 453
Cdd:COG5048   437 HKKIHTNHAPLLCSILKSFRRDLD 460
zf-H2C2_2 pfam13465
Zinc-finger double domain;
454-479 8.38e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 8.38e-04
                          10        20
                  ....*....|....*....|....*.
gi 1039733661 454 NLQIHERTHTGEKPYACNQCGKAFAS 479
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
511-535 1.07e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.07e-03
                          10        20
                  ....*....|....*....|....*
gi 1039733661 511 LQVHERTHTGEKPHQCTQCGKAFVS 535
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
342-367 1.14e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.14e-03
                          10        20
                  ....*....|....*....|....*.
gi 1039733661 342 YLEVHKRIHTGEKPYECSQCSKAFAN 367
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 4-44 3.21e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 80.98  E-value: 3.21e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1039733661   4 VTYEDVHVNFTHEEWALLDSSQKSLYKDVMLETCRNLTAIG 44
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
4-45 3.85e-17

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 75.71  E-value: 3.85e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1039733661    4 VTYEDVHVNFTHEEWALLDSSQKSLYKDVMLETCRNLTAIGY 45
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGF 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-41 4.59e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 74.89  E-value: 4.59e-17
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1039733661   4 VTYEDVHVNFTHEEWALLDSSQKSLYKDVMLETCRNLT 41
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
81-453 1.15e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.95  E-value: 1.15e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039733661  81 KKQCSFACNSFLQMYERIYNEEKAYECNQYS--KAFVNFHSLPQHAKNHPREQPYECNHCGKAYV--------------- 143
Cdd:COG5048    38 NCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGcdKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNskasssslsssssns 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039733661 144 -----SPSSQIHKRSHVGEKPYECSKCgKAFENDNHLQNREKHHTLEKLFECSQC-----GKAFASRSYLPIHRRIHTGE 213
Cdd:COG5048   118 ndnnlLSSHSLPPSSRDPQLPDLLSIS-NLRNNPLPGNNSSSVNTPQSNSLHPPLpanslSKDPSSNLSLLISSNVSTSI 196

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039733661 214 KPYECTQCGKAFTSRSYLKIHKSVHTGEKPYECNQCSKAF------ANFYSLRQHEKYHTREKPYECSHCSKAFPSPSSL 287
Cdd:COG5048   197 PSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPN 276

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039733661 288 QVHERTHTG-EKPYDCTECGKAFISHSSLQIHKR--VHTGE--KPYECT--LCGKAFVNRSYLEVHKRIHTGEKPYEC-- 358
Cdd:COG5048   277 ESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKEkl 356

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039733661 359 SQCSKAF-----ANFRSLRQHEKNHTREKPYEC--SQCSKAFVSPCHLQIHQRTHTGEKP--YDCSDCGKAFTRLSNLQV 429
Cdd:COG5048   357 LNSSSKFspllnNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIP 436

                         410       420
                  ....*....|....*....|....
gi 1039733661 430 HKRTHTGQKPYCCSQCGKAFPCFS 453
Cdd:COG5048   437 HKKIHTNHAPLLCSILKSFRRDLD 460
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
158-538 6.72e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.64  E-value: 6.72e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039733661 158 KPYECSKCGKAFENDNHLQNREKHHTLEKLFECSQ--CGKAFASRSYLPIHRRIHTGEKPYECT-QCGKAFTSRSYLKIH 234
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039733661 235 KSVHTGEKPYECNQCSKAFANFYSLRQHEKYHTREKPYECSHCSKAF----------------------PSPSSLQVHER 292
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSvntpqsnslhpplpanslskdpSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039733661 293 THTGEK-PYDCTECGKAFISHSSLQIHKRVH--TGEKPYECTLCGKA-FVNRSYLEVHKRIHTGEKPyECSQCSKAFANF 368
Cdd:COG5048   192 VSTSIPsSSENSPLSSSYSIPSSSSDQNLENssSSLPLTTNSQLSPKsLLSQSPSSLSSSDSSSSAS-ESPRSSLPTASS 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039733661 369 RSLRQHEKNHTREK----PYECSQCSKAFVSPCHLQIHQRT--HTGE--KPYDC--SDCGKAFTRLSNLQVHKRTHTGQK 438
Cdd:COG5048   271 QSSSPNESDSSSEKgfslPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSIS 350

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039733661 439 PYCC--SQCGKAFPCFSN-----LQIHERTHTGEKPYAC--NQCGKAFASRASLQYHEKHHTGEKPYGC--SQCGKGFAL 507
Cdd:COG5048   351 PAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNR 430

                         410       420       430
                  ....*....|....*....|....*....|.
gi 1039733661 508 RSLLQVHERTHTGEKPHQCTQCGKAFVSRSY 538
Cdd:COG5048   431 HYNLIPHKKIHTNHAPLLCSILKSFRRDLDL 461
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
118-342 4.07e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.78  E-value: 4.07e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039733661 118 HSLPQHAKNHPREQPYE----CNHCGKAYVSPSSQIHKRSHVGEKPYECSKCGKAFENDNHLQNREKHHTL--------- 184
Cdd:COG5048   194 TSIPSSSENSPLSSSYSipssSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSlptassqss 273

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039733661 185 -------------EKLFECSQCGKAFASRSYLPIHRR--IHTGE--KPYECT--QCGKAFTSRSYLKIHKSVHTGEKPYE 245
Cdd:COG5048   274 spnesdsssekgfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISPAK 353

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039733661 246 C--NQCSKAF-----ANFYSLRQHEKYHTREKPYECSH--CSKAFPSPSSLQVHERTHTGEKP--YDCTECGKAFISHSS 314
Cdd:COG5048   354 EklLNSSSKFspllnNEPPQSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYN 433

                         250       260
                  ....*....|....*....|....*...
gi 1039733661 315 LQIHKRVHTGEKPYECTLCGKAFVNRSY 342
Cdd:COG5048   434 LIPHKKIHTNHAPLLCSILKSFRRDLDL 461
zf-H2C2_2 pfam13465
Zinc-finger double domain;
454-479 8.38e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 8.38e-04
                          10        20
                  ....*....|....*....|....*.
gi 1039733661 454 NLQIHERTHTGEKPYACNQCGKAFAS 479
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
511-535 1.07e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.07e-03
                          10        20
                  ....*....|....*....|....*
gi 1039733661 511 LQVHERTHTGEKPHQCTQCGKAFVS 535
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
342-367 1.14e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.14e-03
                          10        20
                  ....*....|....*....|....*.
gi 1039733661 342 YLEVHKRIHTGEKPYECSQCSKAFAN 367
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 408-491 1.81e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.86  E-value: 1.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039733661 408 GEKPYDCS--DCGKAFTRLSNLQVHKRT-HtgqkpycCSQCGKAFPCFSNLQIHErthTGEKPYACNQCGKAFASRASLQ 484
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHMLHgH-------QNQKLHENPSPEKMNIFS---AKDKPYRCEVCDKRYKNLNGLK 415


                  ....*..
gi 1039733661 485 YHEKHHT 491
Cdd:COG5189   416 YHRKHSH 422
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 240-319 1.85e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.86  E-value: 1.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039733661 240 GEKPYECN--QCSKAFANFYSLrqheKYHTREkpyecSHCSKAFPSPSSLQVHERTHTGEKPYDCTECGKAFISHSSLQI 317
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGL----KYHMLH-----GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ..
gi 1039733661 318 HK 319
Cdd:COG5189   417 HR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 352-435 2.15e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.86  E-value: 2.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039733661 352 GEKPYECS--QCSKAFANFRSLRQHEKNHtrekpyECSQCSKAFVSPchlQIHQRTHTGEKPYDCSDCGKAFTRLSNLQV 429
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHMLHG------HQNQKLHENPSP---EKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*.
gi 1039733661 430 HkRTHT 435
Cdd:COG5189   417 H-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
426-449 2.30e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.30e-03
                          10        20
                  ....*....|....*....|....
gi 1039733661 426 NLQVHKRTHTGQKPYCCSQCGKAF 449
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
286-311 2.40e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.40e-03
                          10        20
                  ....*....|....*....|....*.
gi 1039733661 286 SLQVHERTHTGEKPYDCTECGKAFIS 311
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
398-423 2.67e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.67e-03
                          10        20
                  ....*....|....*....|....*.
gi 1039733661 398 HLQIHQRTHTGEKPYDCSDCGKAFTR 423
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 204-267 2.94e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.47  E-value: 2.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039733661 204 PIHRRIHTGEKPYEC--TQCGKAFTSRSYLKIHK-------------------SVHTGEKPYECNQCSKAFANFYSLRQH 262
Cdd:COG5189   338 PSRMLKVKDGKPYKCpvEGCNKKYKNQNGLKYHMlhghqnqklhenpspekmnIFSAKDKPYRCEVCDKRYKNLNGLKYH 417


                  ....*
gi 1039733661 263 EKYHT 267
Cdd:COG5189   418 RKHSH 422
zf-H2C2_2 pfam13465
Zinc-finger double domain;
314-339 3.62e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.62e-03
                          10        20
                  ....*....|....*....|....*.
gi 1039733661 314 SLQIHKRVHTGEKPYECTLCGKAFVN 339
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
370-395 4.54e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.54e-03
                          10        20
                  ....*....|....*....|....*.
gi 1039733661 370 SLRQHEKNHTREKPYECSQCSKAFVS 395
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
206-227 7.56e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 7.56e-03
                          10        20
                  ....*....|....*....|..
gi 1039733661 206 HRRIHTGEKPYECTQCGKAFTS 227
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
258-281 9.39e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 9.39e-03
                          10        20
                  ....*....|....*....|....
gi 1039733661 258 SLRQHEKYHTREKPYECSHCSKAF 281
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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