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Conserved domains on  [gi|1207186964|ref|XP_021327014|]
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gastrula zinc finger protein XlCGF57.1-like [Danio rerio]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
41-413 7.88e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.40  E-value: 7.88e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207186964  41 HLQTSGDKNHFACTQCGTSCSRKSHLKVHMRIHTGEKPFTCTQ--CGKSFSVLSNLNKHMKIHTEEKPFicTQCGKSCRR 118
Cdd:COG5048    24 LKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSD--LNSKSLPLS 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207186964 119 KEDLKVHMRFHTGEKPFTCTECgksfrlSQQLTHHMRIHTGEKPFtcsqcgKSFIQLSNLNDHVKIhtgeksftcsqcGK 198
Cdd:COG5048   102 NSKASSSSLSSSSSNSNDNNLL------SSHSLPPSSRDPQLPDL------LSISNLRNNPLPGNN------------SS 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207186964 199 NFSRSSTLNNHMRIHTGEKPFPCTECGKVFRlsphltqHMRIHTGEKTFTCSQCGKSFIQLSNLSNHMKIHTGEKPFTCT 278
Cdd:COG5048   158 SVNTPQSNSLHPPLPANSLSKDPSSNLSLLI-------SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLT 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207186964 279 QCGKSFIFSSSLNNHMKIHSGEKPFTCTQCGRSFILSSNLNQHMRIHTGE-------KPFTCTECGKSFSHSSCFKFHMN 351
Cdd:COG5048   231 TNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLR 310

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207186964 352 --IHTGE--KPFTC--SQCGKIFRSSPNLNQHMKIHTGEKPFTC--TQCGKSFNQSSDLNQHMKIHTEVG 413
Cdd:COG5048   311 svNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQQYKD 380
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
41-413 7.88e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.40  E-value: 7.88e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207186964  41 HLQTSGDKNHFACTQCGTSCSRKSHLKVHMRIHTGEKPFTCTQ--CGKSFSVLSNLNKHMKIHTEEKPFicTQCGKSCRR 118
Cdd:COG5048    24 LKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSD--LNSKSLPLS 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207186964 119 KEDLKVHMRFHTGEKPFTCTECgksfrlSQQLTHHMRIHTGEKPFtcsqcgKSFIQLSNLNDHVKIhtgeksftcsqcGK 198
Cdd:COG5048   102 NSKASSSSLSSSSSNSNDNNLL------SSHSLPPSSRDPQLPDL------LSISNLRNNPLPGNN------------SS 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207186964 199 NFSRSSTLNNHMRIHTGEKPFPCTECGKVFRlsphltqHMRIHTGEKTFTCSQCGKSFIQLSNLSNHMKIHTGEKPFTCT 278
Cdd:COG5048   158 SVNTPQSNSLHPPLPANSLSKDPSSNLSLLI-------SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLT 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207186964 279 QCGKSFIFSSSLNNHMKIHSGEKPFTCTQCGRSFILSSNLNQHMRIHTGE-------KPFTCTECGKSFSHSSCFKFHMN 351
Cdd:COG5048   231 TNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLR 310

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207186964 352 --IHTGE--KPFTC--SQCGKIFRSSPNLNQHMKIHTGEKPFTC--TQCGKSFNQSSDLNQHMKIHTEVG 413
Cdd:COG5048   311 svNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQQYKD 380
zf-H2C2_2 pfam13465
Zinc-finger double domain;
317-342 3.97e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 3.97e-05
                          10        20
                  ....*....|....*....|....*.
gi 1207186964 317 NLNQHMRIHTGEKPFTCTECGKSFSH 342
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
41-413 7.88e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.40  E-value: 7.88e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207186964  41 HLQTSGDKNHFACTQCGTSCSRKSHLKVHMRIHTGEKPFTCTQ--CGKSFSVLSNLNKHMKIHTEEKPFicTQCGKSCRR 118
Cdd:COG5048    24 LKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSD--LNSKSLPLS 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207186964 119 KEDLKVHMRFHTGEKPFTCTECgksfrlSQQLTHHMRIHTGEKPFtcsqcgKSFIQLSNLNDHVKIhtgeksftcsqcGK 198
Cdd:COG5048   102 NSKASSSSLSSSSSNSNDNNLL------SSHSLPPSSRDPQLPDL------LSISNLRNNPLPGNN------------SS 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207186964 199 NFSRSSTLNNHMRIHTGEKPFPCTECGKVFRlsphltqHMRIHTGEKTFTCSQCGKSFIQLSNLSNHMKIHTGEKPFTCT 278
Cdd:COG5048   158 SVNTPQSNSLHPPLPANSLSKDPSSNLSLLI-------SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLT 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207186964 279 QCGKSFIFSSSLNNHMKIHSGEKPFTCTQCGRSFILSSNLNQHMRIHTGE-------KPFTCTECGKSFSHSSCFKFHMN 351
Cdd:COG5048   231 TNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLR 310

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207186964 352 --IHTGE--KPFTC--SQCGKIFRSSPNLNQHMKIHTGEKPFTC--TQCGKSFNQSSDLNQHMKIHTEVG 413
Cdd:COG5048   311 svNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQQYKD 380
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
38-405 4.09e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.92  E-value: 4.09e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207186964  38 EKNHLQTSGDKNHFACTQCGTSCSRK--SHLKVHMRIHTGEKPFTCTQ----------------CGKSFSVLSNLNKHMK 99
Cdd:COG5048    49 LTRHIRSHTGEKPSQCSYSGCDKSFSrpLELSRHLRTHHNNPSDLNSKslplsnskasssslssSSSNSNDNNLLSSHSL 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207186964 100 IHTEEKPFICTQCGKSCRRKEDLKVHMRFHTGEK-------PFTCTECGKSFRLSQQLTHHMRIHTGEKPFTCSQCGKSF 172
Cdd:COG5048   129 PPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPqsnslhpPLPANSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSS 208

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207186964 173 IQLSNLNDHVKIHTGEKSFTCSQCGKNFSRSSTLNNHMRIHTGEKPFPCTECGKVFRLSPHLTQHMRIHTGEKT------ 246
Cdd:COG5048   209 YSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSekgfsl 288

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207186964 247 -FTCSQCGKSFIQLSNLSNHM--KIHTGE--KPFTCT--QCGKSFIFSSSLNNHMKIHSGEKPFTCTQCGRSFILSSNLN 319
Cdd:COG5048   289 pIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLN 368

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207186964 320 -------QHMRIHTGEKPFTCT--ECGKSFSHSSCFKFHMNIHTGEKP--FTCSQCGKIFRSSPNLNQHMKIHTGEKPFt 388
Cdd:COG5048   369 neppqslQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL- 447

                         410
                  ....*....|....*..
gi 1207186964 389 CTQCGKSFNQSSDLNQH 405
Cdd:COG5048   448 LCSILKSFRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
317-342 3.97e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 3.97e-05
                          10        20
                  ....*....|....*....|....*.
gi 1207186964 317 NLNQHMRIHTGEKPFTCTECGKSFSH 342
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
373-398 6.68e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 6.68e-05
                          10        20
                  ....*....|....*....|....*.
gi 1207186964 373 NLNQHMKIHTGEKPFTCTQCGKSFNQ 398
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
65-89 1.34e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.34e-04
                          10        20
                  ....*....|....*....|....*
gi 1207186964  65 HLKVHMRIHTGEKPFTCTQCGKSFS 89
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
121-144 4.02e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 4.02e-04
                          10        20
                  ....*....|....*....|....
gi 1207186964 121 DLKVHMRFHTGEKPFTCTECGKSF 144
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
261-284 4.94e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 4.94e-04
                          10        20
                  ....*....|....*....|....
gi 1207186964 261 NLSNHMKIHTGEKPFTCTQCGKSF 284
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
233-258 9.08e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 9.08e-04
                          10        20
                  ....*....|....*....|....*.
gi 1207186964 233 HLTQHMRIHTGEKTFTCSQCGKSFIQ 258
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
206-228 1.00e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.00e-03
                          10        20
                  ....*....|....*....|...
gi 1207186964 206 LNNHMRIHTGEKPFPCTECGKVF 228
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
153-174 1.50e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.50e-03
                          10        20
                  ....*....|....*....|..
gi 1207186964 153 HMRIHTGEKPFTCSQCGKSFIQ 174
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
289-312 4.82e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 4.82e-03
                          10        20
                  ....*....|....*....|....
gi 1207186964 289 SLNNHMKIHSGEKPFTCTQCGRSF 312
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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