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Conserved domains on  [gi|1207182975|ref|XP_021333962|]
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TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X2 [Danio rerio]

Protein Classification

TGF-beta-activated kinase 1 and MAP3K7-binding protein 3( domain architecture ID 12996902)

TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 (TAB3) is an adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF)

Gene Symbol:  TAB3
Gene Ontology:  GO:0070530|GO:0008270|GO:0043130
PubMed:  14633987|14670075|12665246|12628920

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CUE_TAB2_TAB3 cd14362
CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins ...
 10-51 9.29e-17

CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins; TAB2, also called mitogen-activated protein kinase kinase kinase 7-interacting protein 2, TAK1-binding protein 2, or TGF-beta-activated kinase 1-binding protein 2, is an adaptor protein that regulates activation of TAK1, a MAP kinase kinase kinase (MAPKKK), through linking TAK1 to TRAF6 in the Interleukin-1 (IL-1) induced NF-kappaB activation pathway. TAB3, also called mitogen-activated protein kinase kinase kinase 7-interacting protein 3, NF-kappa-B-activating protein 1, TAK1-binding protein 3, or TGF-beta-activated kinase 1-binding protein 3, is a TAB2-like TAK1-binding protein that activates NF-kappaB similar to TAB2. It activates TAK1 and regulates its association with TRAF2 and TRAF6. Moreover, TAB3 interacts with TRAF6 and TRAF2 in an IL-1- and a TNF-dependent manner, respectively. In summary, TAB2 and TAB3 function redundantly as mediators of TAK1 activation in IL-1 and TNF signal transduction. Both of them contain an N-terminal CUE domain, a coiled-coil (CC) region, a TAK1-binding domain and a C-terminal Npl4 zinc finger (NZF) ubiquitin-binding domain (UBD).


:

Pssm-ID: 270545  Cd Length: 42  Bit Score: 73.88  E-value: 9.29e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1207182975  10 DYQILQDLRQRFPEIPETVVSQYLLQNNNNADLCYHLLAQES 51
Cdd:cd14362     1 DMQLFHELKQRFPEVPDAVVSQCMLQNNHNREACCAALQKES 42
ZnF_RBZ smart00547
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. ...
 523-546 2.67e-05

Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. In RanBPs, this domain binds RanGDP.


:

Pssm-ID: 197784 [Multi-domain]  Cd Length: 25  Bit Score: 41.15  E-value: 2.67e-05
                           10        20
                   ....*....|....*....|....
gi 1207182975  523 QWNCESCTFLNHPALHRCEQCEMP 546
Cdd:smart00547   2 DWECPACTFLNFASRSKCFACGAP 25
PHA03378 super family cl33729
EBNA-3B; Provisional
 112-423 5.90e-05

EBNA-3B; Provisional


The actual alignment was detected with superfamily member PHA03378:

Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 46.21  E-value: 5.90e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182975 112 EPLSAP-----ATVAPSPGYNPFFKTDQSRSnipTPPPSIPGMSPTYHPVSRYMTPITvtlsqnmPSAPQALQIPPGTYc 186
Cdd:PHA03378  575 QPLTSPttsqlASSAPSYAQTPWPVPHPSQT---PEPPTTQSHIPETSAPRQWPMPLR-------PIPMRPLRMQPITF- 643

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182975 187 tsgnTVYMRPSPSQSPQPTP------WSTSGTSMYQQSPyATPTYQSPYSSPQHQVQQPPQVFLPISPPTLPglsyqqtP 260
Cdd:PHA03378  644 ----NVLVFPTPHQPPQVEItpykptWTQIGHIPYQPSP-TGANTMLPIQWAPGTMQPPPRAPTPMRPPAAP-------P 711

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182975 261 VSQRPFISSKGPMKNQIEITLEGQRPRSNSPVHTPQGALYMATSPSPSSPSRAISMAGPPGASIHQGMYAHQAVARPRPT 340
Cdd:PHA03378  712 GRAQRPAAATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGAPTPQPPPQAPPAPQQRPR 791

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182975 341 SSPQPAPSAfikiKVSPRQVQGSSNSPPVETESLLNIVDQGERHGAPPPiLPISALPGSIANQINCMPRRSSSGSDDYAY 420
Cdd:PHA03378  792 GAPTPQPPP----QAGPTSMQLMPRAAPGQQGPTKQILRQLLTGGVKRG-RPSLKKPAALERQAAAGPTPSPGSGTSDKI 866


                  ...
gi 1207182975 421 TQA 423
Cdd:PHA03378  867 VQA 869
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
421-509 2.39e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


:

Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 40.27  E-value: 2.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182975 421 TQALLLHQRARMERLMKELMLERQKLDQLKAEVNEmefdaLQRRFRRVNsTSLIPRPEEMTKIRSQNRQLQIDIDCTLKE 500
Cdd:COG4372    50 LREELEQAREELEQLEEELEQARSELEQLEEELEE-----LNEQLQAAQ-AELAQAQEELESLQEEAEELQEELEELQKE 123


                  ....*....
gi 1207182975 501 TDLLQSRAK 509
Cdd:COG4372   124 RQDLEQQRK 132
 
Name Accession Description Interval E-value
CUE_TAB2_TAB3 cd14362
CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins ...
 10-51 9.29e-17

CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins; TAB2, also called mitogen-activated protein kinase kinase kinase 7-interacting protein 2, TAK1-binding protein 2, or TGF-beta-activated kinase 1-binding protein 2, is an adaptor protein that regulates activation of TAK1, a MAP kinase kinase kinase (MAPKKK), through linking TAK1 to TRAF6 in the Interleukin-1 (IL-1) induced NF-kappaB activation pathway. TAB3, also called mitogen-activated protein kinase kinase kinase 7-interacting protein 3, NF-kappa-B-activating protein 1, TAK1-binding protein 3, or TGF-beta-activated kinase 1-binding protein 3, is a TAB2-like TAK1-binding protein that activates NF-kappaB similar to TAB2. It activates TAK1 and regulates its association with TRAF2 and TRAF6. Moreover, TAB3 interacts with TRAF6 and TRAF2 in an IL-1- and a TNF-dependent manner, respectively. In summary, TAB2 and TAB3 function redundantly as mediators of TAK1 activation in IL-1 and TNF signal transduction. Both of them contain an N-terminal CUE domain, a coiled-coil (CC) region, a TAK1-binding domain and a C-terminal Npl4 zinc finger (NZF) ubiquitin-binding domain (UBD).


Pssm-ID: 270545  Cd Length: 42  Bit Score: 73.88  E-value: 9.29e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1207182975  10 DYQILQDLRQRFPEIPETVVSQYLLQNNNNADLCYHLLAQES 51
Cdd:cd14362     1 DMQLFHELKQRFPEVPDAVVSQCMLQNNHNREACCAALQKES 42
CUE pfam02845
CUE domain; CUE domains have been shown to bind ubiquitin. It has been suggested that CUE ...
 12-51 9.04e-06

CUE domain; CUE domains have been shown to bind ubiquitin. It has been suggested that CUE domains are related to pfam00627 and this has been confirmed by the structure of the domain. CUE domains also occur in two protein of the IL-1 signal transduction pathway, tollip and TAB2.


Pssm-ID: 427018  Cd Length: 42  Bit Score: 42.85  E-value: 9.04e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1207182975  12 QILQDLRQRFPEIPETVVSQYLLQNNNNADLCYHLLAQES 51
Cdd:pfam02845   3 QMLETLKEMFPDLDEEVIRAVLEASNGNVEAAINALLEGS 42
ZnF_RBZ smart00547
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. ...
 523-546 2.67e-05

Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. In RanBPs, this domain binds RanGDP.


Pssm-ID: 197784 [Multi-domain]  Cd Length: 25  Bit Score: 41.15  E-value: 2.67e-05
                           10        20
                   ....*....|....*....|....
gi 1207182975  523 QWNCESCTFLNHPALHRCEQCEMP 546
Cdd:smart00547   2 DWECPACTFLNFASRSKCFACGAP 25
PHA03378 PHA03378
EBNA-3B; Provisional
 112-423 5.90e-05

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 46.21  E-value: 5.90e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182975 112 EPLSAP-----ATVAPSPGYNPFFKTDQSRSnipTPPPSIPGMSPTYHPVSRYMTPITvtlsqnmPSAPQALQIPPGTYc 186
Cdd:PHA03378  575 QPLTSPttsqlASSAPSYAQTPWPVPHPSQT---PEPPTTQSHIPETSAPRQWPMPLR-------PIPMRPLRMQPITF- 643

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182975 187 tsgnTVYMRPSPSQSPQPTP------WSTSGTSMYQQSPyATPTYQSPYSSPQHQVQQPPQVFLPISPPTLPglsyqqtP 260
Cdd:PHA03378  644 ----NVLVFPTPHQPPQVEItpykptWTQIGHIPYQPSP-TGANTMLPIQWAPGTMQPPPRAPTPMRPPAAP-------P 711

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182975 261 VSQRPFISSKGPMKNQIEITLEGQRPRSNSPVHTPQGALYMATSPSPSSPSRAISMAGPPGASIHQGMYAHQAVARPRPT 340
Cdd:PHA03378  712 GRAQRPAAATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGAPTPQPPPQAPPAPQQRPR 791

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182975 341 SSPQPAPSAfikiKVSPRQVQGSSNSPPVETESLLNIVDQGERHGAPPPiLPISALPGSIANQINCMPRRSSSGSDDYAY 420
Cdd:PHA03378  792 GAPTPQPPP----QAGPTSMQLMPRAAPGQQGPTKQILRQLLTGGVKRG-RPSLKKPAALERQAAAGPTPSPGSGTSDKI 866


                  ...
gi 1207182975 421 TQA 423
Cdd:PHA03378  867 VQA 869
CUE smart00546
Domain that may be involved in binding ubiquitin-conjugating enzymes (UBCs); CUE domains also ...
 12-51 4.86e-04

Domain that may be involved in binding ubiquitin-conjugating enzymes (UBCs); CUE domains also occur in two protein of the IL-1 signal transduction pathway, tollip and TAB2. Ponting (Biochem. J.) "Proteins of the Endoplasmic reticulum" (in press)


Pssm-ID: 214715  Cd Length: 43  Bit Score: 37.86  E-value: 4.86e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1207182975   12 QILQDLRQRFPEIPETVVSQYLLQNNNNADLCYHLLAQES 51
Cdd:smart00546   4 EALHDLKEMFPNLDEEVIEAVLEANTGNVEATINNLLEGS 43
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
421-509 2.39e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 40.27  E-value: 2.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182975 421 TQALLLHQRARMERLMKELMLERQKLDQLKAEVNEmefdaLQRRFRRVNsTSLIPRPEEMTKIRSQNRQLQIDIDCTLKE 500
Cdd:COG4372    50 LREELEQAREELEQLEEELEQARSELEQLEEELEE-----LNEQLQAAQ-AELAQAQEELESLQEEAEELQEELEELQKE 123


                  ....*....
gi 1207182975 501 TDLLQSRAK 509
Cdd:COG4372   124 RQDLEQQRK 132
zf-RanBP pfam00641
Zn-finger in Ran binding protein and others;
523-547 7.32e-03

Zn-finger in Ran binding protein and others;


Pssm-ID: 395516 [Multi-domain]  Cd Length: 30  Bit Score: 34.25  E-value: 7.32e-03
                          10        20
                  ....*....|....*....|....*
gi 1207182975 523 QWNCESCTFLNHPALHRCEQCEMPR 547
Cdd:pfam00641   4 DWDCSKCLVQNFATSTKCVACQAPK 28
 
Name Accession Description Interval E-value
CUE_TAB2_TAB3 cd14362
CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins ...
 10-51 9.29e-17

CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins; TAB2, also called mitogen-activated protein kinase kinase kinase 7-interacting protein 2, TAK1-binding protein 2, or TGF-beta-activated kinase 1-binding protein 2, is an adaptor protein that regulates activation of TAK1, a MAP kinase kinase kinase (MAPKKK), through linking TAK1 to TRAF6 in the Interleukin-1 (IL-1) induced NF-kappaB activation pathway. TAB3, also called mitogen-activated protein kinase kinase kinase 7-interacting protein 3, NF-kappa-B-activating protein 1, TAK1-binding protein 3, or TGF-beta-activated kinase 1-binding protein 3, is a TAB2-like TAK1-binding protein that activates NF-kappaB similar to TAB2. It activates TAK1 and regulates its association with TRAF2 and TRAF6. Moreover, TAB3 interacts with TRAF6 and TRAF2 in an IL-1- and a TNF-dependent manner, respectively. In summary, TAB2 and TAB3 function redundantly as mediators of TAK1 activation in IL-1 and TNF signal transduction. Both of them contain an N-terminal CUE domain, a coiled-coil (CC) region, a TAK1-binding domain and a C-terminal Npl4 zinc finger (NZF) ubiquitin-binding domain (UBD).


Pssm-ID: 270545  Cd Length: 42  Bit Score: 73.88  E-value: 9.29e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1207182975  10 DYQILQDLRQRFPEIPETVVSQYLLQNNNNADLCYHLLAQES 51
Cdd:cd14362     1 DMQLFHELKQRFPEVPDAVVSQCMLQNNHNREACCAALQKES 42
CUE pfam02845
CUE domain; CUE domains have been shown to bind ubiquitin. It has been suggested that CUE ...
 12-51 9.04e-06

CUE domain; CUE domains have been shown to bind ubiquitin. It has been suggested that CUE domains are related to pfam00627 and this has been confirmed by the structure of the domain. CUE domains also occur in two protein of the IL-1 signal transduction pathway, tollip and TAB2.


Pssm-ID: 427018  Cd Length: 42  Bit Score: 42.85  E-value: 9.04e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1207182975  12 QILQDLRQRFPEIPETVVSQYLLQNNNNADLCYHLLAQES 51
Cdd:pfam02845   3 QMLETLKEMFPDLDEEVIRAVLEASNGNVEAAINALLEGS 42
ZnF_RBZ smart00547
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. ...
 523-546 2.67e-05

Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. In RanBPs, this domain binds RanGDP.


Pssm-ID: 197784 [Multi-domain]  Cd Length: 25  Bit Score: 41.15  E-value: 2.67e-05
                           10        20
                   ....*....|....*....|....
gi 1207182975  523 QWNCESCTFLNHPALHRCEQCEMP 546
Cdd:smart00547   2 DWECPACTFLNFASRSKCFACGAP 25
PHA03378 PHA03378
EBNA-3B; Provisional
 112-423 5.90e-05

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 46.21  E-value: 5.90e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182975 112 EPLSAP-----ATVAPSPGYNPFFKTDQSRSnipTPPPSIPGMSPTYHPVSRYMTPITvtlsqnmPSAPQALQIPPGTYc 186
Cdd:PHA03378  575 QPLTSPttsqlASSAPSYAQTPWPVPHPSQT---PEPPTTQSHIPETSAPRQWPMPLR-------PIPMRPLRMQPITF- 643

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182975 187 tsgnTVYMRPSPSQSPQPTP------WSTSGTSMYQQSPyATPTYQSPYSSPQHQVQQPPQVFLPISPPTLPglsyqqtP 260
Cdd:PHA03378  644 ----NVLVFPTPHQPPQVEItpykptWTQIGHIPYQPSP-TGANTMLPIQWAPGTMQPPPRAPTPMRPPAAP-------P 711

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182975 261 VSQRPFISSKGPMKNQIEITLEGQRPRSNSPVHTPQGALYMATSPSPSSPSRAISMAGPPGASIHQGMYAHQAVARPRPT 340
Cdd:PHA03378  712 GRAQRPAAATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGAPTPQPPPQAPPAPQQRPR 791

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182975 341 SSPQPAPSAfikiKVSPRQVQGSSNSPPVETESLLNIVDQGERHGAPPPiLPISALPGSIANQINCMPRRSSSGSDDYAY 420
Cdd:PHA03378  792 GAPTPQPPP----QAGPTSMQLMPRAAPGQQGPTKQILRQLLTGGVKRG-RPSLKKPAALERQAAAGPTPSPGSGTSDKI 866


                  ...
gi 1207182975 421 TQA 423
Cdd:PHA03378  867 VQA 869
CUE smart00546
Domain that may be involved in binding ubiquitin-conjugating enzymes (UBCs); CUE domains also ...
 12-51 4.86e-04

Domain that may be involved in binding ubiquitin-conjugating enzymes (UBCs); CUE domains also occur in two protein of the IL-1 signal transduction pathway, tollip and TAB2. Ponting (Biochem. J.) "Proteins of the Endoplasmic reticulum" (in press)


Pssm-ID: 214715  Cd Length: 43  Bit Score: 37.86  E-value: 4.86e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1207182975   12 QILQDLRQRFPEIPETVVSQYLLQNNNNADLCYHLLAQES 51
Cdd:smart00546   4 EALHDLKEMFPNLDEEVIEAVLEANTGNVEATINNLLEGS 43
PHA03247 PHA03247
large tegument protein UL36; Provisional
 80-368 1.66e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.46  E-value: 1.66e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182975   80 PVPDGVKNIPGGRALVHSSSDGHIEHPRSGFPEPLSAPATVAPSPGYNPFFKTDQSRSNIPTP-PPSIPGMSPTYHPVSR 158
Cdd:PHA03247  2748 PATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAvLAPAAALPPAASPAGP 2827

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182975  159 YMTPITVT-LSQNMPSAPQALQIPPGTYCTSGNTVYMRPsPSQSPQPTPwstsgtsmyqqspyATPTyQSPYSSPQHQVQ 237
Cdd:PHA03247  2828 LPPPTSAQpTAPPPPPGPPPPSLPLGGSVAPGGDVRRRP-PSRSPAAKP--------------AAPA-RPPVRRLARPAV 2891

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182975  238 QPPQVFLPISPPTLPGLSYQQTPVSQRPFISSKGPMKNQIEITLEGQRPRSNSPVHTPQGAlymatspspsspsraiSMA 317
Cdd:PHA03247  2892 SRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGA----------------GEP 2955

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1207182975  318 GPPGASIHQGMYAHQAVARPRpTSSPQPAPSafikikvspRQVQGSSNSPP 368
Cdd:PHA03247  2956 SGAVPQPWLGALVPGRVAVPR-FRVPQPAPS---------REAPASSTPPL 2996
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
421-509 2.39e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 40.27  E-value: 2.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182975 421 TQALLLHQRARMERLMKELMLERQKLDQLKAEVNEmefdaLQRRFRRVNsTSLIPRPEEMTKIRSQNRQLQIDIDCTLKE 500
Cdd:COG4372    50 LREELEQAREELEQLEEELEQARSELEQLEEELEE-----LNEQLQAAQ-AELAQAQEELESLQEEAEELQEELEELQKE 123


                  ....*....
gi 1207182975 501 TDLLQSRAK 509
Cdd:COG4372   124 RQDLEQQRK 132
PHA03247 PHA03247
large tegument protein UL36; Provisional
 107-371 2.44e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.08  E-value: 2.44e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182975  107 RSGFPEPLSAPATVAPSPG-YNPFFKTDQSRSNIP-TPPPSIPGMSPTYHPVSRYMTPITVTLSQNMPSAPQALQippgt 184
Cdd:PHA03247  2729 RQASPALPAAPAPPAVPAGpATPGGPARPARPPTTaGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWD----- 2803

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182975  185 yctsgntvymrPSPSQSPQPTPWSTSGTSMYQQSPYATPTYQSPYSSPQHQVQQPPQvfLPISPPTLPGLSYQQTPVSQR 264
Cdd:PHA03247  2804 -----------PADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPS--LPLGGSVAPGGDVRRRPPSRS 2870

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182975  265 PFISSKGPMKNQIEITLEGQRPRSNSPVHTPQGALYMATSPSPSSPSRAISMAGPPGASIHQGMYAHQAVARPRPTSSPQ 344
Cdd:PHA03247  2871 PAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPA 2950

                          250       260       270
                   ....*....|....*....|....*....|....*...
gi 1207182975  345 PAPS-----------AFIKIKVSPRQVQGSSNSPPVET 371
Cdd:PHA03247  2951 GAGEpsgavpqpwlgALVPGRVAVPRFRVPQPAPSREA 2988
zf-RanBP pfam00641
Zn-finger in Ran binding protein and others;
523-547 7.32e-03

Zn-finger in Ran binding protein and others;


Pssm-ID: 395516 [Multi-domain]  Cd Length: 30  Bit Score: 34.25  E-value: 7.32e-03
                          10        20
                  ....*....|....*....|....*
gi 1207182975 523 QWNCESCTFLNHPALHRCEQCEMPR 547
Cdd:pfam00641   4 DWDCSKCLVQNFATSTKCVACQAPK 28
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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