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Conserved domains on  [gi|1229151253|ref|XP_022088178|]
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methylosome subunit pICln-like [Acanthaster planci]

Protein Classification

Voldacs domain-containing protein( domain architecture ID 10507568)

Voldacs (volume decrease after cellular swelling) domain-containing protein similar to Homo sapiens methylosome subunit pICln that is involved in both the assembly of spliceosomal snRNPs and the methylation of Sm proteins

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Voldacs pfam03517
Regulator of volume decrease after cellular swelling; ICln is a ubiquitously expressed ...
 33-172 4.66e-35

Regulator of volume decrease after cellular swelling; ICln is a ubiquitously expressed multi-functional protein that plays a critical role in regulating volume decrease in cells after cellular swelling. In plants, ICln induces Cl- currents, thus regulating Cl- homoeostasis in eukaryotes. Structurally, the fold resembles a pleckstrin homology fold, on of whose roles is to recruit and tether their host protein to the cell membrane; and although the surface charges of the ICln fold are not equivalent to those of the PH domain, ICln can be phosphorylated in vitro and the PH-nature of the domain may be the part involving it in the transposition from cytosol to cell membrane during cytotonic swelling.


:

Pssm-ID: 427344  Cd Length: 139  Bit Score: 121.75  E-value: 4.66e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229151253  33 GSLFIAESCVAWINA-TGQGLKVPYPAISLHAVSRDLTAFPHECLYLMIDaavmpEILQIPSFRDSGGAGDN-NEDGTEE 110
Cdd:pfam03517   1 GDLYVTSSRLLWFNAeRNSGISIPYPSISLHAISRDPESFPEPCLYCQLD-----AIIDELGSDDLDGEGDEeDENEDDD 75

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1229151253 111 DVDGAIREFRFIPDDK--QALEQMFSAMSSCQTLHPDPDDSEPSDEDYGDEFEDAEEGSDLEEG 172
Cdd:pfam03517  76 EEEESSVELRLVPKDPsdSMLDAIYDALSACQELHPDPDDEDDEDDGDPGDDEEEEEEEEDEDG 139
 
Name Accession Description Interval E-value
Voldacs pfam03517
Regulator of volume decrease after cellular swelling; ICln is a ubiquitously expressed ...
 33-172 4.66e-35

Regulator of volume decrease after cellular swelling; ICln is a ubiquitously expressed multi-functional protein that plays a critical role in regulating volume decrease in cells after cellular swelling. In plants, ICln induces Cl- currents, thus regulating Cl- homoeostasis in eukaryotes. Structurally, the fold resembles a pleckstrin homology fold, on of whose roles is to recruit and tether their host protein to the cell membrane; and although the surface charges of the ICln fold are not equivalent to those of the PH domain, ICln can be phosphorylated in vitro and the PH-nature of the domain may be the part involving it in the transposition from cytosol to cell membrane during cytotonic swelling.


Pssm-ID: 427344  Cd Length: 139  Bit Score: 121.75  E-value: 4.66e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229151253  33 GSLFIAESCVAWINA-TGQGLKVPYPAISLHAVSRDLTAFPHECLYLMIDaavmpEILQIPSFRDSGGAGDN-NEDGTEE 110
Cdd:pfam03517   1 GDLYVTSSRLLWFNAeRNSGISIPYPSISLHAISRDPESFPEPCLYCQLD-----AIIDELGSDDLDGEGDEeDENEDDD 75

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1229151253 111 DVDGAIREFRFIPDDK--QALEQMFSAMSSCQTLHPDPDDSEPSDEDYGDEFEDAEEGSDLEEG 172
Cdd:pfam03517  76 EEEESSVELRLVPKDPsdSMLDAIYDALSACQELHPDPDDEDDEDDGDPGDDEEEEEEEEDEDG 139
 
Name Accession Description Interval E-value
Voldacs pfam03517
Regulator of volume decrease after cellular swelling; ICln is a ubiquitously expressed ...
 33-172 4.66e-35

Regulator of volume decrease after cellular swelling; ICln is a ubiquitously expressed multi-functional protein that plays a critical role in regulating volume decrease in cells after cellular swelling. In plants, ICln induces Cl- currents, thus regulating Cl- homoeostasis in eukaryotes. Structurally, the fold resembles a pleckstrin homology fold, on of whose roles is to recruit and tether their host protein to the cell membrane; and although the surface charges of the ICln fold are not equivalent to those of the PH domain, ICln can be phosphorylated in vitro and the PH-nature of the domain may be the part involving it in the transposition from cytosol to cell membrane during cytotonic swelling.


Pssm-ID: 427344  Cd Length: 139  Bit Score: 121.75  E-value: 4.66e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229151253  33 GSLFIAESCVAWINA-TGQGLKVPYPAISLHAVSRDLTAFPHECLYLMIDaavmpEILQIPSFRDSGGAGDN-NEDGTEE 110
Cdd:pfam03517   1 GDLYVTSSRLLWFNAeRNSGISIPYPSISLHAISRDPESFPEPCLYCQLD-----AIIDELGSDDLDGEGDEeDENEDDD 75

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1229151253 111 DVDGAIREFRFIPDDK--QALEQMFSAMSSCQTLHPDPDDSEPSDEDYGDEFEDAEEGSDLEEG 172
Cdd:pfam03517  76 EEEESSVELRLVPKDPsdSMLDAIYDALSACQELHPDPDDEDDEDDGDPGDDEEEEEEEEDEDG 139
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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