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Conserved domains on  [gi|1370513837|ref|XP_024303194|]
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tRNA methyltransferase 10 homolog B isoform X3 [Homo sapiens]

Protein Classification

RNA methyltransferase; RsmE family RNA methyltransferase( domain architecture ID 13031075)

SpoU family RNA methyltransferase catalyzes the methylation of rRNA or tRNA at specific sites in a S-adenosyl-L-methionine (SAM)-dependent manner; RsmE family RNA methyltransferase similar to 16S rRNA (uracil(1498)-N(3))-methyltransferase RsmE that specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Trm10euk_B cd18100
eukaryotic tRNA m1G9 methyltransferase Trm10 homolog B; Eukaryotic tRNA m1G9 methyltransferase ...
 125-298 6.39e-110

eukaryotic tRNA m1G9 methyltransferase Trm10 homolog B; Eukaryotic tRNA m1G9 methyltransferase Trm10 homolog B (TM10B) catalyzes the N(1) methylation of guanine at Position 9 (m(1)G9) of tRNA, which might play a role in the stabilization of tRNA and in translation termination efficiency. Trm10 is a member of the SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


:

Pssm-ID: 349973  Cd Length: 182  Bit Score: 316.51  E-value: 6.39e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513837 125 PRLCIDLSMTHYMSKKELSRLAGQIRRLYGSNKKADRPFWICLTGFTTDSPLYEECVRMNDGFSSYLLDITEEDCFSLFP 204
Cdd:cd18100     1 LRVCIDLSLEHKMSEKEISKLAQQLRRLYGSNRKAEKPLHIYLTSFDKEGLLYKECVRKNDGFENYLIDMTEESHSELFP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513837 205 LETLVYLTPDSEHALEDVDLNKVYILGGLVDESIQKKVTFQKAREYSVKTARLPIQEYMVRNQnGKNYHSEILAINQ--- 281
Cdd:cd18100    81 KEEIVYLSPDSENVLESIDPNKVYVIGGLVDESIQKKLTLQKAKEHGIQTARLPIDEYMVKAD-GKGNYSTVLAINQvfd 159

                         170       180
                  ....*....|....*....|...
gi 1370513837 282 ------ETHNWPEALKKGVSSGK 298
Cdd:cd18100   160 illkyyETGDWREALSAGVPQRK 182
 
Name Accession Description Interval E-value
Trm10euk_B cd18100
eukaryotic tRNA m1G9 methyltransferase Trm10 homolog B; Eukaryotic tRNA m1G9 methyltransferase ...
 125-298 6.39e-110

eukaryotic tRNA m1G9 methyltransferase Trm10 homolog B; Eukaryotic tRNA m1G9 methyltransferase Trm10 homolog B (TM10B) catalyzes the N(1) methylation of guanine at Position 9 (m(1)G9) of tRNA, which might play a role in the stabilization of tRNA and in translation termination efficiency. Trm10 is a member of the SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349973  Cd Length: 182  Bit Score: 316.51  E-value: 6.39e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513837 125 PRLCIDLSMTHYMSKKELSRLAGQIRRLYGSNKKADRPFWICLTGFTTDSPLYEECVRMNDGFSSYLLDITEEDCFSLFP 204
Cdd:cd18100     1 LRVCIDLSLEHKMSEKEISKLAQQLRRLYGSNRKAEKPLHIYLTSFDKEGLLYKECVRKNDGFENYLIDMTEESHSELFP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513837 205 LETLVYLTPDSEHALEDVDLNKVYILGGLVDESIQKKVTFQKAREYSVKTARLPIQEYMVRNQnGKNYHSEILAINQ--- 281
Cdd:cd18100    81 KEEIVYLSPDSENVLESIDPNKVYVIGGLVDESIQKKLTLQKAKEHGIQTARLPIDEYMVKAD-GKGNYSTVLAINQvfd 159

                         170       180
                  ....*....|....*....|...
gi 1370513837 282 ------ETHNWPEALKKGVSSGK 298
Cdd:cd18100   160 illkyyETGDWREALSAGVPQRK 182
tRNA_m1G_MT pfam01746
tRNA (Guanine-1)-methyltransferase; This is a family of tRNA (Guanine-1)-methyltransferases EC: ...
 136-298 2.17e-42

tRNA (Guanine-1)-methyltransferase; This is a family of tRNA (Guanine-1)-methyltransferases EC:2.1.1.31. In E.coli K12 this enzyme catalyzes the conversion of a guanosine residue to N1-methylguanine in position 37, next to the anticodon, in tRNA.


Pssm-ID: 396350  Cd Length: 182  Bit Score: 144.41  E-value: 2.17e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513837 136 YMSKKELSRLAGQIRRLYGSNKKADRPFWICLTGFTTDSPLYEECVRMND----GFSSYLLD-----ITEEDCFSLFPLE 206
Cdd:pfam01746   2 LAQEKGLVSLVVQNLRDYTANRRNTVDDEPYGGGFGMVLKPEPEFEALESvnyeKWKVILLTptgkpFFQEGAVDLSQKE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513837 207 TLVYLTPDSEHALEDVDLNKVYILGGLVDESIQKKV----TFQKAREYSVKTARLPIQEYMvrnqNGKNYHSEILAINQ- 281
Cdd:pfam01746  82 HLVYLCGDYEGVDERVDDDKEYSIGDFVDKGGEKGAlvliDLVKRLLPGVLTASLPIDSFL----LEKPHYTRPLTLNQv 157

                         170       180
                  ....*....|....*....|....*
gi 1370513837 282 --------ETHNWPEALKKGVSSGK 298
Cdd:pfam01746 158 peillsgnHIRNWKEALLRTIPRRK 182
 
Name Accession Description Interval E-value
Trm10euk_B cd18100
eukaryotic tRNA m1G9 methyltransferase Trm10 homolog B; Eukaryotic tRNA m1G9 methyltransferase ...
 125-298 6.39e-110

eukaryotic tRNA m1G9 methyltransferase Trm10 homolog B; Eukaryotic tRNA m1G9 methyltransferase Trm10 homolog B (TM10B) catalyzes the N(1) methylation of guanine at Position 9 (m(1)G9) of tRNA, which might play a role in the stabilization of tRNA and in translation termination efficiency. Trm10 is a member of the SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349973  Cd Length: 182  Bit Score: 316.51  E-value: 6.39e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513837 125 PRLCIDLSMTHYMSKKELSRLAGQIRRLYGSNKKADRPFWICLTGFTTDSPLYEECVRMNDGFSSYLLDITEEDCFSLFP 204
Cdd:cd18100     1 LRVCIDLSLEHKMSEKEISKLAQQLRRLYGSNRKAEKPLHIYLTSFDKEGLLYKECVRKNDGFENYLIDMTEESHSELFP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513837 205 LETLVYLTPDSEHALEDVDLNKVYILGGLVDESIQKKVTFQKAREYSVKTARLPIQEYMVRNQnGKNYHSEILAINQ--- 281
Cdd:cd18100    81 KEEIVYLSPDSENVLESIDPNKVYVIGGLVDESIQKKLTLQKAKEHGIQTARLPIDEYMVKAD-GKGNYSTVLAINQvfd 159

                         170       180
                  ....*....|....*....|...
gi 1370513837 282 ------ETHNWPEALKKGVSSGK 298
Cdd:cd18100   160 illkyyETGDWREALSAGVPQRK 182
SPOUT_Trm10-like cd18089
tRNA methyltransferase Trm10-like; Family of tRNA methyltransferase Trm10-like proteins ...
 125-292 1.11e-47

tRNA methyltransferase Trm10-like; Family of tRNA methyltransferase Trm10-like proteins catalyzes the N(1) methylation of guanine at position 9 (m(1)G9) of tRNA (eukaryotes) or N(1) methylation of guanine or adenine at position 9 (m1G9/m1A9) of tRNA (archaea), which might play a role in the stabilization of tRNA and in translation termination efficiency. Trm10 is a member of the SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349962  Cd Length: 171  Bit Score: 157.31  E-value: 1.11e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513837 125 PRLCIDLSMTHYMSKKELSRLAGQIRRLYGSNKKADRPFWICLTGFTTDSPLYEECVRMNDGFSSYLLDITEEDCFsLFP 204
Cdd:cd18089     1 PRIVIDLSFDDLMTEKEIRSLAKQLSRCYGANRRSEKPLRLHLTSFSGDLKQRLLKKSGAENWKIITHEESLLEEE-AFP 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513837 205 LETLVYLTPDSEHALEDVDLNKVYILGGLVDESIQKKVTFQKAREYSVKTARLPIQEYMVRNqngknyHSEILAINQ--- 281
Cdd:cd18089    80 KEKLVYLTADAEEVLEELDPDKVYIIGGIVDRNRHKGLTLNKAEELGIRTARLPIREYIKLK------GRKVLTVNHvfe 153

                         170
                  ....*....|....*..
gi 1370513837 282 ------ETHNWPEALKK 292
Cdd:cd18089   154 illrylEGGDWKEALEE 170
tRNA_m1G_MT pfam01746
tRNA (Guanine-1)-methyltransferase; This is a family of tRNA (Guanine-1)-methyltransferases EC: ...
 136-298 2.17e-42

tRNA (Guanine-1)-methyltransferase; This is a family of tRNA (Guanine-1)-methyltransferases EC:2.1.1.31. In E.coli K12 this enzyme catalyzes the conversion of a guanosine residue to N1-methylguanine in position 37, next to the anticodon, in tRNA.


Pssm-ID: 396350  Cd Length: 182  Bit Score: 144.41  E-value: 2.17e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513837 136 YMSKKELSRLAGQIRRLYGSNKKADRPFWICLTGFTTDSPLYEECVRMND----GFSSYLLD-----ITEEDCFSLFPLE 206
Cdd:pfam01746   2 LAQEKGLVSLVVQNLRDYTANRRNTVDDEPYGGGFGMVLKPEPEFEALESvnyeKWKVILLTptgkpFFQEGAVDLSQKE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513837 207 TLVYLTPDSEHALEDVDLNKVYILGGLVDESIQKKV----TFQKAREYSVKTARLPIQEYMvrnqNGKNYHSEILAINQ- 281
Cdd:pfam01746  82 HLVYLCGDYEGVDERVDDDKEYSIGDFVDKGGEKGAlvliDLVKRLLPGVLTASLPIDSFL----LEKPHYTRPLTLNQv 157

                         170       180
                  ....*....|....*....|....*
gi 1370513837 282 --------ETHNWPEALKKGVSSGK 298
Cdd:pfam01746 158 peillsgnHIRNWKEALLRTIPRRK 182
Trm10_MRRP1 cd18102
Mitochondrial ribonuclease P protein 1; Mitochondrial ribonuclease P protein 1 (or tRNA ...
 125-295 1.69e-41

Mitochondrial ribonuclease P protein 1; Mitochondrial ribonuclease P protein 1 (or tRNA methyltransferase 10 homolog C) functions in mitochondrial tRNA maturation and is part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/RG9MTD1, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends. MRRP1 is related to Trm10, a tRNA m1G9 methyltransferase and is a member of the SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349975  Cd Length: 179  Bit Score: 141.91  E-value: 1.69e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513837 125 PRLCIDLSMTHYMSKKELSRLAGQIRRLYGSNKKADRPFWICLTGFTTDSPLYEECVRMNDG--FSSYLLDITEEDCFSL 202
Cdd:cd18102     1 QPLVIDMSYEDLMSPREIKNTARQLLEAYSANRRSTEPFHLHFCNLDPDGESIKRLLRLIPKlsLDKFPITVTEKSYLDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513837 203 FPLETLVYLTPDSEHALEDVDLNKVYILGGLVDESIQKKVTFQKAREYSVKTARLPIQEYMVRNQNGKNyhseiLAINQ- 281
Cdd:cd18102    81 FPKEKLVYLSPDAPEVLKEFDPDKVYIIGGLVDKSTKKPLSLAKAKKEGIRMARLPLDRYLKWGGGSKS-----LTLNQv 155

                         170       180
                  ....*....|....*....|..
gi 1370513837 282 --------ETHNWPEALKKGVS 295
Cdd:cd18102   156 vsilldlkDTGDWKEALKHVPP 177
Trm10euk_A cd18101
eukaryotic tRNA m1G9 methyltransferase Trm10 homolog A; Eukaryotic tRNA m1G9 methyltransferase ...
 126-292 4.59e-38

eukaryotic tRNA m1G9 methyltransferase Trm10 homolog A; Eukaryotic tRNA m1G9 methyltransferase Trm10 homolog A (TM10A) catalyzes the N(1) methylation of guanine at Position 9 (m(1)G9) of tRNA, which might play a role in the stabilization of tRNA and in translation termination efficiency. Trm10 is a member of the SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349974  Cd Length: 174  Bit Score: 132.73  E-value: 4.59e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513837 126 RLCIDLSMTHYMSKKELSRLAGQIRRLYGSNKKADRPFWICLTGFTTDSPLYEECvrmNDGFSSYLLDITEEDCFSLFPL 205
Cdd:cd18101     2 RVAIDCSFDDLMTEKDIKKLVKQIQRCYAENRRADNPVQLYLTSLGGKTKENMEK---DKGYENWDVNFKEEHYLEVFKK 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513837 206 ETLVYLTPDSEHALEDVDLNKVYILGGLVDESIQKKVTFQKAREYSVKTARLPIQEYMVRNQngknyhSEILAINQ---- 281
Cdd:cd18101    79 EDIVYLTSDSPNVLEDLDEDKVYIIGGLVDHNHHKGLCYKRAVELGIQHARLPIDEYVKMKT------RKVLTINHvfei 152

                         170
                  ....*....|....*.
gi 1370513837 282 -----ETHNWPEALKK 292
Cdd:cd18101   153 llrytEGKDWKEAFFK 168
Trm10arch cd18099
archaeal tRNA(m1G9/m1A9)-methyltransferase Trm10; Archaeal tRNA(m1G9/m1A9)-methyltransferase ...
 125-241 7.81e-04

archaeal tRNA(m1G9/m1A9)-methyltransferase Trm10; Archaeal tRNA(m1G9/m1A9)-methyltransferase Trm10 catalyzes the N(1) methylation of guanine or adenine at position 9 (m1G9/m1A9) of tRNA, which might play a role in the stabilization of tRNA and in translation termination efficiency. Trm10 is a member of the SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349972  Cd Length: 170  Bit Score: 39.69  E-value: 7.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370513837 125 PRLCIDLSMTHYMSKKELSRLAGQIRRLYGSNKKAdrpFW---ICLTGftTDSPLYEECVRMNDGFSSYLLDITEEDcfs 201
Cdd:cd18099     1 PYFIIDLSLWDLHTEKEKKKLVLQVLLSIGVIRKY---LWdgnLVLTW--ANSMFLEMLNKVESLSLYTVGLKEKGE--- 72

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1370513837 202 lfplETLVYLTPDSEHALEDVDL--NKVYILGGLVDESIQKK 241
Cdd:cd18099    73 ----DNAVLLDPYAEEVATEDIIrdTKAFIIGGIVDKGGNKK 110
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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