|
Name |
Accession |
Description |
Interval |
E-value |
| PLN03128 |
PLN03128 |
DNA topoisomerase 2; Provisional |
12-1167 |
0e+00 |
|
DNA topoisomerase 2; Provisional
Pssm-ID: 215593 [Multi-domain] Cd Length: 1135 Bit Score: 2179.09 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 12 KTIEEIYQKKTPLEHVLLRPDTYVGSIEKHTQTLWVYEGGQLVNRAVTYVPGLYKIFDEILVNAADNKQRDPSMDAVKVT 91
Cdd:PLN03128 1 KTIEETYQKKTQLEHILLRPDTYIGSTEKHTQTLWVYEGGEMVNREVTYVPGLYKIFDEILVNAADNKQRDPSMDSLKVD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 92 ISVEQNTISVYNNGDGVPVEVHNEQGVYVPEMIFGHLLTSSNYDDNEKKTTGGRNGYGAKLANIFSTEFVIETADGKRGK 171
Cdd:PLN03128 81 IDVEQNTISVYNNGKGIPVEIHKEEGVYVPELIFGHLLTSSNFDDNEKKTTGGRNGYGAKLANIFSTEFTVETADGNRGK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 172 KYKQVFSNNMSAKSEPAISSCKSNENWTKVTFKPDLAKFHMTYLEEDVVALMSKRVLDIAGCLGRTVKVELNGQKLPVKT 251
Cdd:PLN03128 161 KYKQVFTNNMSVKSEPKITSCKASENWTKITFKPDLAKFNMTRLDEDVVALMSKRVYDIAGCLGKKLKVELNGKKLPVKS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 252 FSDYVGLYLASAQKgkEETLPRIYERANDRWEVCVSLSDGQFQQVSFVNSIATIRGGTHVQHVSEQIVSHIQE-IVNKKN 330
Cdd:PLN03128 241 FQDYVGLYLGPNSR--EDPLPRIYEKVNDRWEVCVSLSDGSFQQVSFVNSIATIKGGTHVDYVADQIVKHIQEkVKKKNK 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 331 KNANVKGFQIRNHLWVFVNSLIDNPAFDSQTKETLTTRQTSFGSKCELSPEFLKKVSKCGVVDNVLSWADFKQSKELKKN 410
Cdd:PLN03128 319 NATHVKPFQIKNHLWVFVNCLIENPTFDSQTKETLTTRPSSFGSKCELSEEFLKKVEKCGVVENILSWAQFKQQKELKKK 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 411 DGAKRQRLTGIAKLDDANDAGGKNSEACTLILTEGDSAKALAvssvfalsafltfcclqMSGISVVGRNHYGVFPLRGKL 490
Cdd:PLN03128 399 DGAKRQRLTGIPKLDDANDAGGKKSKDCTLILTEGDSAKALA-----------------MSGLSVVGRDHYGVFPLRGKL 461
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 491 LNVREATHKQIMDNAEITSIKQILGLQQGKGY--ENTKSLRYGHLMIMTDQDHDGSHIKGLIINFIHTFWPSLLKVPGFL 568
Cdd:PLN03128 462 LNVREASHKQIMKNAEITNIKQILGLQFGKTYdeENTKSLRYGHLMIMTDQDHDGSHIKGLIINFFHSFWPSLLKIPGFL 541
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 569 VEFITPIVKATHKnGKVLSFYTMPEYESWKESLRGETKGWSIKYYKGLGTSTAKEGKEYFRDLVKHKKDFAWDNDEDGDS 648
Cdd:PLN03128 542 VEFITPIVKATKG-GKSLSFYTMPEYEAWKESLEGETKGWTIKYYKGLGTSTSEEAKEYFSNLDIHKKEFLWQSDEDGDL 620
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 649 IELAFSKKKTEARKIWLRGYQPGTFLDQTQRVITYSDFINKELILFSLADLARSVPSMVDGLKPGQRKILFAAFKRNFTS 728
Cdd:PLN03128 621 IDMAFSKKRVEDRKIWLNNYEPGTFLDQTGNGISYSDFINKELILFSQADLARSIPSMVDGLKPSQRKVLFACFKRNLKS 700
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 729 QAKVAQFSGYVSEHSAYHHGEQSLASTIIGMAQNFVGSNNINILAPIGQFGTRSQGGKDHASARYIYTSLTPLTRTIFPK 808
Cdd:PLN03128 701 EIKVAQLSGYVAEHSAYHHGEASLASTIIGMAQDFVGSNNINLLTPSGQFGTRLQGGKDAASARYIFTRLSPITRALFPK 780
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 809 PDDILLNFLREDGQSIEPFWYAPILPMVLVNGSEGIGTGWSTFVPNYNPRDIVTNLKHLLRDEQLEPMDPWYKGFKGTIV 888
Cdd:PLN03128 781 DDDVLLNYLNEDGQSIEPEWYCPIIPMVLVNGSEGIGTGWSTFIPNYNPRDIIANIRRLLRGEELEPMHPWYRGFKGTIT 860
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 889 KSATKESGvSYTVTGIVEQVNETTIRVLELPIRKWTQDYKEFLEALLCGTeKIKEPSIKDYREHNTDTRVHFEISLSEEK 968
Cdd:PLN03128 861 EVSTSRSG-SYTVTGIIEQIGDTTIRITELPVRKWTQDYKEFLEALLTGT-KKKEPEIKDFKENHTDTTVHFTVTLSEEK 938
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 969 MAEALAEGLTKKFKLSTTISTSNMNLFDKDGHIRKYDTPEQILEDFYHIRLELYVKRKEVQVENLQYELLKLDNKVRFIL 1048
Cdd:PLN03128 939 MARALAEGLEKKFKLSTTISTSNMHLFDKDGKIKKYDSPEDILEEFFHLRLDLYVKRKEVLLENLEYELKKLDNKARFIL 1018
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 1049 GVVKGEIVVNNRKRAELLVELKTKGFTPFPKKAKASDLPVVGGDGSdvEADDEEKLNKGVRAGDYEYLLSMPIGTLTLEK 1128
Cdd:PLN03128 1019 AVVKGEIVVNNRKRAELLAELEEKGFDKFPKTAKISETNVVGDRDG--EASEEEEASDNELAKSYDYLLGMPISSLTLEK 1096
|
1130 1140 1150
....*....|....*....|....*....|....*....
gi 1376976423 1129 VQQLCNERDKLEGDVEELKKCTPKDLWEKDLDNFLEQLT 1167
Cdd:PLN03128 1097 VDELRAERAKKETEVEELKKTTPEDLWRKDLDAFEEALD 1135
|
|
| TOP2c |
smart00433 |
TopoisomeraseII; Eukaryotic DNA topoisomerase II, GyrB, ParE |
63-668 |
0e+00 |
|
TopoisomeraseII; Eukaryotic DNA topoisomerase II, GyrB, ParE
Pssm-ID: 214659 [Multi-domain] Cd Length: 594 Bit Score: 746.30 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 63 GLYKIFDEILVNAADNKQRDPsMDAVKVTISVEqNTISVYNNGDGVPVEVHNEQGVYVPEMIFGHLLTSSNYDDNEKKTT 142
Cdd:smart00433 1 GLHHLVDEIVDNAADEALAGY-MDTIKVTIDKD-NSISVEDNGRGIPVEIHPKEKKYAPEVIFTVLHAGGKFDDDAYKVS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 143 GGRNGYGAKLANIFSTEFVIETADGkrGKKYKQVFSNNMSAKSEPAISSCkSNENWTKVTFKPDLAKFHMTylEEDVVAL 222
Cdd:smart00433 79 GGLHGVGASVVNALSTEFEVEVARD--GKEYKQSFSNNGKPLSEPKIIGD-TKKDGTKVTFKPDLEIFGMT--TDDDFEL 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 223 MSKRVLDIAGCLgRTVKVELNGQK-------LPVKTFSDYVGLYLASAQKGKEETLPRIYERANDRWEVCVSLSDG-QFQ 294
Cdd:smart00433 154 LKRRLRELAFLN-KGVKITLNDERsdeektfLFEGGIKDYVELLNKNKELLSPEPTYIEGEKDNIRVEVAFQYTDGySEN 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 295 QVSFVNSIATIRGGTHVQHVSEQIVSHIQEIVNKKNKNANVK--GFQIRNHLWVFVNSLIDNPAFDSQTKETLTTRQTSF 372
Cdd:smart00433 233 IVSFVNNIATTEGGTHENGFKDALTRVINEYAKKKKKLKEKNikGEDVREGLTAFISVKIPEPQFEGQTKEKLGTSEVRF 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 373 G-----SKCELSPEFLKKVSKCGVVDNVLSWADFK-QSKELKKNDGAK-RQRLTGIAKLDDANDAGGKNseaCTLILTEG 445
Cdd:smart00433 313 GvekivSECLLSFLEENPVEASKIVEKVLLAAKARaAAKKARELTRKKkLSSISLPGKLADASSAGPKK---CELFLVEG 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 446 DSAKALAVSsvfALSafltfcclqmsgisvvgRNHYGVFPLRGKLLNVREATHKQIMDNAEITSIKQILGLQQGKGYeNT 525
Cdd:smart00433 390 DSAGGSAKS---GRD-----------------RDFQAILPLRGKILNVEKASLDKILKNEEIQALITALGLGIGKDF-DI 448
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 526 KSLRYGHLMIMTDQDHDGSHIKGLIINFIHTFWPSLLKVpGFLVEFITPIVKATHKNG-KVLSFYTMPEYESWKESLRGE 604
Cdd:smart00433 449 EKLRYGKIIIMTDADVDGSHIKGLLLTFFYRYMPPLIEA-GFVYIAIPPLYKVTKGKKkYVYSFYSLDEYEKWLEKTEGN 527
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1376976423 605 TKGWSIKYYKGLGTSTAKEGKEYFRDLVKHKKDFAW-DNDEDGDSIELAFSKKKTEARKIWLRGY 668
Cdd:smart00433 528 KSKYEIQRYKGLGEMNADQLWETTMDPERRTLLFVTlDDADEADLIFSALMGDKVEPRKEWIEEN 592
|
|
| TOP4c |
cd00187 |
DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), ... |
700-1162 |
1.82e-149 |
|
DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA topology by catalysing the concerted breakage and rejoining of DNA strands during normal cellular growth.
Pssm-ID: 238111 [Multi-domain] Cd Length: 445 Bit Score: 460.88 E-value: 1.82e-149
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 700 ARSVPSMVDGLKPGQRKILFAAFKRNFTSQA---KVAQFSGYVSEHSaYHHGEQSLASTIIGMAQNFvgSNNINILAPIG 776
Cdd:cd00187 2 GRALPDVRDGLKPVQRRILYAMFKRGLTPDKpekKVARLVGDVAGKY-HPHGDSSLYDTIVRMAQDF--SNNIPLLDPQG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 777 QFGTRsqGGKDHASARYIYTSLTPLTRTIFPKPDDILLNFLRE-DGQSIEPFWYAPILPMVLVNGSEGIGTGWSTFVPNY 855
Cdd:cd00187 79 NFGSR--DGDDAAAMRYTETRLSPIARLLLPDIDDPTVDFVPNyDGQEVEPEVLPPIFPNLLVNGSSGIAVGMATNIPPH 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 856 NPRDIVTNLKHLLRDEQLE-------PMDPWYKGFkGTI-----VKSATKESGVSYTVTGIVEQV---NETTIRVLELPI 920
Cdd:cd00187 157 NLREVIDALRALIDNPEASidelmeiIKGPDFPTG-GIIegragIREAYETGRGRYIIRGKYEIEddeGRNTIEITELPY 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 921 RKWTQDYKEFLEALLcgTEKiKEPSIKDYREHNTDTRVHFEISLSEEKMAEALAEGLTKKFKLSTTISTsNMNLFDKDGH 1000
Cdd:cd00187 236 QVNKAKLKEKIAELV--KDK-KIEGISDVRDESDREGIRFVIELKRGAMAEVVLNGLYKVTKLQTTFGI-NMVAFDPNGR 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 1001 IRKYdTPEQILEDFYHIRLELYVKRKEVQVENLQYELLKLDNKVRFILGVvkgeIVVNNRKR------AELLVELKTKGF 1074
Cdd:cd00187 312 PKKL-NLKEILQEFLDHRLEVYTRRKEYELGKAEARLHILEGLLKAILNI----DEVINLIRssdeakKALIEELEKLGF 386
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 1075 TPFpkkakasdlpvvggdgsdveaddeeklnkgvragDYEYLLSMPIGTLTLEKVQQLCNERDKLEGDVEELKKCT---- 1150
Cdd:cd00187 387 SEI----------------------------------QADAILDMRLRRLTKLEREKLLKELKELEAEIEDLEKILasee 432
|
490
....*....|...
gi 1376976423 1151 -PKDLWEKDLDNF 1162
Cdd:cd00187 433 rPKDLWKEELDEF 445
|
|
| DNA_topoisoIV |
pfam00521 |
DNA gyrase/topoisomerase IV, subunit A; |
701-1160 |
3.28e-146 |
|
DNA gyrase/topoisomerase IV, subunit A;
Pssm-ID: 459843 [Multi-domain] Cd Length: 432 Bit Score: 451.62 E-value: 3.28e-146
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 701 RSVPSMVDGLKPGQRKILFAAFK-RNFTSQ-AKVAQFSGYVseHSAYH-HGEQSLASTIIGMAQNFVGsnNINILAPIGQ 777
Cdd:pfam00521 1 RAIPDVRDGLKPVQRRILYAMFElLNLDKPyKKVARLVGDV--MGKYHpHGDASLYDAIVRMAQDFVG--NIPLLDGQGN 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 778 FGTRSQGGKDhASARYIYTSLTPLTRTIFPKPDDILLNFLRE-DGQSIEPFWYAPILPMVLVNGSEGIGTGWSTFVPNYN 856
Cdd:pfam00521 77 FGSRIDGDKD-AAMRYTETRLSKIARELFPDIDDDTVDYVPNyDGTEVEPTVLPPIIPNLLVNGAEGIAVGMATNIPPHN 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 857 PRDIVTNLKHLLRDEQLE-----PMDPWYKGFKGTIVKSATKE---SGV-SYTVTGIVEQVNETTIRVLELPIRKWTQDY 927
Cdd:pfam00521 156 LREIIDALIALLDGPEATllmkyIMGPDFPTGGGIIGKGGIKEaykTGRgKITVRAKVEIEDRKTIVITELPYGVWTSDL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 928 KEFLEALLcGTEKIKEpsIKDYREHnTDTRVHFEISLSEEKMAEALAEGLTKKFKLSTTISTSNMNLFDkdgHIRKYDTP 1007
Cdd:pfam00521 236 IEKIEELV-KNGKIKG--ISDIRDE-SDRGVRIVIELKRGADPEVVLNDLYKKTKLQTSFSTNNLVLFD---GGPKYLGL 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 1008 EQILEDFYHIRLELYVKRKEVQVENLQYELLKLD------NKVRFILGVVKGEIvVNNRKRAELLVELKTKgftpfpkka 1081
Cdd:pfam00521 309 KEILKEFLDHRLEVYERRKEYLLEKLEERLHILEgllialNNIDFVIEIIRGSI-DRKKAKKNLIEELSEI--------- 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 1082 kasdlpvvggdgsdveaddeeklnkgvragDYEYLLSMPIGTLTLEKVQQLCNERDKLEGDVEELKKCTPK-----DLWE 1156
Cdd:pfam00521 379 ------------------------------QADYLLDMRLRRLTKEEVDKLLEEIDELEKEIAELEKLLASekklnDLWI 428
|
....
gi 1376976423 1157 KDLD 1160
Cdd:pfam00521 429 EELD 432
|
|
| GyrB |
COG0187 |
DNA gyrase/topoisomerase IV, subunit B [Replication, recombination and repair]; |
24-617 |
3.15e-33 |
|
DNA gyrase/topoisomerase IV, subunit B [Replication, recombination and repair];
Pssm-ID: 439957 [Multi-domain] Cd Length: 635 Bit Score: 137.85 E-value: 3.15e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 24 LEHVLLRPDTYVGSiekhtqtlwvyeggqlvnravTYVPGLYKIFDEILvnaaDNkqrdpSMD--------AVKVTISvE 95
Cdd:COG0187 17 LEAVRKRPGMYIGS---------------------TDERGLHHLVWEIV----DN-----SIDealagycdRIEVTLH-A 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 96 QNTISVYNNGDGVPVEVHNEQGVYVPEMI---------FGhlltSSNYddnekKTTGGRNGYGAKLANIFSTEFVIETad 166
Cdd:COG0187 66 DGSVTVEDNGRGIPVDIHPKEGKSALEVVltvlhaggkFD----GGSY-----KVSGGLHGVGASVVNALSERLEVEV-- 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 167 gKR-GKKYKQVFSnnmsaKSEPaISSCK----SNENWTKVTFKPDLAKFHMTYLEEDVVA--LMSKRVLdIAGclgrtVK 239
Cdd:COG0187 135 -KRdGKIYRQRFE-----RGKP-VGPLEkigkTDRTGTTVRFKPDPEIFETTEFDYETLAerLRELAFL-NKG-----LT 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 240 VELN---GQKLPVKTF------SDYVgLYLAsaqKGKEE-TLPRIY---ERANDRWEVCVSLSDGQFQQV-SFVNSIATI 305
Cdd:COG0187 202 ITLTderEEEPKEETFhyeggiKDFV-EYLN---EDKEPlHPEVIYfegEKDGIEVEVALQWNDGYSENIhSFVNNINTP 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 306 RGGTHV----QHVSEQIVSHIQEIVNKKNKNANVKGFQIRNHLWVFVNSLIDNPAFDSQTKETLTTR------QTSFGSK 375
Cdd:COG0187 278 EGGTHEtgfrTALTRVINDYARKNGLLKEKDKNLTGDDVREGLTAVISVKLPEPQFEGQTKTKLGNSeargivESVVSEK 357
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 376 CElspEFL---KKVSKcGVVDNVLSWADF----KQSKELKKNDGAKRqRLTGIAKLDDANDaggKNSEACTLILTEGDSA 448
Cdd:COG0187 358 LE---HYLeenPAEAK-KILEKAILAARAreaaRKARELVRRKSALE-SSGLPGKLADCSS---KDPEESELFIVEGDSA 429
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 449 kalavssvfalsafltfcclqmsGISVV-GRN-HY-GVFPLRGKLLNVREATHKQIMDNAEITSIKQILGLQQGKGYENT 525
Cdd:COG0187 430 -----------------------GGSAKqGRDrEFqAILPLRGKILNVEKARLDKILKNEEIRDLITALGTGIGDDFDLE 486
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 526 KsLRYGHLMIMTDQDHDGSHIKGLIINFIHTFWPSLLKVpGFLveFI--TPIVKATHKNgKVLSFYTMPEYESWKESLRG 603
Cdd:COG0187 487 K-LRYHKIIIMTDADVDGAHIRTLLLTFFYRYMRPLIEA-GHV--YIaqPPLYRIKKGK-KTYYAYSDAELDELLKELKG 561
|
650
....*....|....
gi 1376976423 604 EtKGWSIKYYKGLG 617
Cdd:COG0187 562 K-KKVEIQRYKGLG 574
|
|
| gyrA |
TIGR01063 |
DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). ... |
700-1052 |
6.12e-18 |
|
DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). Two apparently independently arising families, one in the Proteobacteria and one in Gram-positive lineages, are both designated toposisomerase IV. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273423 [Multi-domain] Cd Length: 800 Bit Score: 90.06 E-value: 6.12e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 700 ARSVPSMVDGLKPGQRKILFAAFKRNFTSQ---AKVAQFSGYVSehSAYH-HGEQSLASTIIGMAQNFvgSNNINILAPI 775
Cdd:TIGR01063 24 SRALPDVRDGLKPVHRRILYAMYELGLTPDkpyKKSARIVGDVM--GKYHpHGDSAIYDTLVRMAQDF--SLRYPLVDGQ 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 776 GQFGtrSQGGKDHASARYIYTSLTPLTRTIFPKPD----DILLNFlreDGQSIEPFWYAPILPMVLVNGSEGIGTGWSTF 851
Cdd:TIGR01063 100 GNFG--SIDGDPPAAMRYTEARLTKIAEELLRDIDketvDFVPNY---DGSEQEPTVLPSRFPNLLVNGSSGIAVGMATN 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 852 VPNYNPRDIVTNLKHLLRDEQLE----------PMDP-------------WYKGFKGTIVKSATKEsgvsytvtgiVEQV 908
Cdd:TIGR01063 175 IPPHNLGEIIDALLAYIDNPDISiqellevikgPDFPtggiilgrsgirsAYETGRGSIVIRARAE----------IEED 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 909 NE--TTIRVLELPirkWTQDYKEFLE--ALLCGTEKIKepSIKDYREHNTDTRVHFEISLSEEKMAEALAEGLTKKFKLS 984
Cdd:TIGR01063 245 SKgrEAIIVTEIP---YQVNKARLIEkiAELVREKKIE--GISDIRDESDREGIRIVIELKRDAVAEVVLNNLYKQTQLQ 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 985 TTISTSNMNLFDKdghirkydTPEQI-LEDFyhirLELYVK-RKEVQVENLQYELLKLDNKVRFILGVVK 1052
Cdd:TIGR01063 320 VSFGINMLALVKG--------LPKVLnLKEL----LEAFVEhRKDVITRRTIFELRKAEERAHILEGLLI 377
|
|
| PRK05035 |
PRK05035 |
electron transport complex protein RnfC; Provisional |
1135-1368 |
1.74e-05 |
|
electron transport complex protein RnfC; Provisional
Pssm-ID: 235334 [Multi-domain] Cd Length: 695 Bit Score: 49.18 E-value: 1.74e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 1135 ERDKLEGdvEELKKCTPKDLWEKDLDNF---LEQLTAQELEEEKEDELELKQMAKEGAAIFKRAAAGRKPAAKAKTADKE 1211
Cdd:PRK05035 463 EREKAAR--EARHKKAAEARAAKDKDAVaaaLARVKAKKAAATQPIVIKAGARPDNSAVIAAREARKAQARARQAEKQAA 540
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 1212 NAVKPTKKATAATKASNASKKAAKPVELDSEEEYFNTSLQDRLAAYAKGKGPLTEDNSMEDAVKEVSPPTkpnAPKAAPV 1291
Cdd:PRK05035 541 AAADPKKAAVAAAIARAKAKKAAQQAANAEAEEEVDPKKAAVAAAIARAKAKKAAQQAASAEPEEQVAEV---DPKKAAV 617
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1376976423 1292 AKKRANTKASKASKATEDVAAhDSPDAKVRKVRASPFNKKSGSvIPQLAKLSIEAEADSDVEAAPQARPKRRAARPA 1368
Cdd:PRK05035 618 AAAIARAKAKKAEQQANAEPE-EPVDPRKAAVAAAIARAKARK-AAQQQANAEPEEAEDPKKAAVAAAIARAKAKKA 692
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PLN03128 |
PLN03128 |
DNA topoisomerase 2; Provisional |
12-1167 |
0e+00 |
|
DNA topoisomerase 2; Provisional
Pssm-ID: 215593 [Multi-domain] Cd Length: 1135 Bit Score: 2179.09 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 12 KTIEEIYQKKTPLEHVLLRPDTYVGSIEKHTQTLWVYEGGQLVNRAVTYVPGLYKIFDEILVNAADNKQRDPSMDAVKVT 91
Cdd:PLN03128 1 KTIEETYQKKTQLEHILLRPDTYIGSTEKHTQTLWVYEGGEMVNREVTYVPGLYKIFDEILVNAADNKQRDPSMDSLKVD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 92 ISVEQNTISVYNNGDGVPVEVHNEQGVYVPEMIFGHLLTSSNYDDNEKKTTGGRNGYGAKLANIFSTEFVIETADGKRGK 171
Cdd:PLN03128 81 IDVEQNTISVYNNGKGIPVEIHKEEGVYVPELIFGHLLTSSNFDDNEKKTTGGRNGYGAKLANIFSTEFTVETADGNRGK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 172 KYKQVFSNNMSAKSEPAISSCKSNENWTKVTFKPDLAKFHMTYLEEDVVALMSKRVLDIAGCLGRTVKVELNGQKLPVKT 251
Cdd:PLN03128 161 KYKQVFTNNMSVKSEPKITSCKASENWTKITFKPDLAKFNMTRLDEDVVALMSKRVYDIAGCLGKKLKVELNGKKLPVKS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 252 FSDYVGLYLASAQKgkEETLPRIYERANDRWEVCVSLSDGQFQQVSFVNSIATIRGGTHVQHVSEQIVSHIQE-IVNKKN 330
Cdd:PLN03128 241 FQDYVGLYLGPNSR--EDPLPRIYEKVNDRWEVCVSLSDGSFQQVSFVNSIATIKGGTHVDYVADQIVKHIQEkVKKKNK 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 331 KNANVKGFQIRNHLWVFVNSLIDNPAFDSQTKETLTTRQTSFGSKCELSPEFLKKVSKCGVVDNVLSWADFKQSKELKKN 410
Cdd:PLN03128 319 NATHVKPFQIKNHLWVFVNCLIENPTFDSQTKETLTTRPSSFGSKCELSEEFLKKVEKCGVVENILSWAQFKQQKELKKK 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 411 DGAKRQRLTGIAKLDDANDAGGKNSEACTLILTEGDSAKALAvssvfalsafltfcclqMSGISVVGRNHYGVFPLRGKL 490
Cdd:PLN03128 399 DGAKRQRLTGIPKLDDANDAGGKKSKDCTLILTEGDSAKALA-----------------MSGLSVVGRDHYGVFPLRGKL 461
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 491 LNVREATHKQIMDNAEITSIKQILGLQQGKGY--ENTKSLRYGHLMIMTDQDHDGSHIKGLIINFIHTFWPSLLKVPGFL 568
Cdd:PLN03128 462 LNVREASHKQIMKNAEITNIKQILGLQFGKTYdeENTKSLRYGHLMIMTDQDHDGSHIKGLIINFFHSFWPSLLKIPGFL 541
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 569 VEFITPIVKATHKnGKVLSFYTMPEYESWKESLRGETKGWSIKYYKGLGTSTAKEGKEYFRDLVKHKKDFAWDNDEDGDS 648
Cdd:PLN03128 542 VEFITPIVKATKG-GKSLSFYTMPEYEAWKESLEGETKGWTIKYYKGLGTSTSEEAKEYFSNLDIHKKEFLWQSDEDGDL 620
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 649 IELAFSKKKTEARKIWLRGYQPGTFLDQTQRVITYSDFINKELILFSLADLARSVPSMVDGLKPGQRKILFAAFKRNFTS 728
Cdd:PLN03128 621 IDMAFSKKRVEDRKIWLNNYEPGTFLDQTGNGISYSDFINKELILFSQADLARSIPSMVDGLKPSQRKVLFACFKRNLKS 700
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 729 QAKVAQFSGYVSEHSAYHHGEQSLASTIIGMAQNFVGSNNINILAPIGQFGTRSQGGKDHASARYIYTSLTPLTRTIFPK 808
Cdd:PLN03128 701 EIKVAQLSGYVAEHSAYHHGEASLASTIIGMAQDFVGSNNINLLTPSGQFGTRLQGGKDAASARYIFTRLSPITRALFPK 780
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 809 PDDILLNFLREDGQSIEPFWYAPILPMVLVNGSEGIGTGWSTFVPNYNPRDIVTNLKHLLRDEQLEPMDPWYKGFKGTIV 888
Cdd:PLN03128 781 DDDVLLNYLNEDGQSIEPEWYCPIIPMVLVNGSEGIGTGWSTFIPNYNPRDIIANIRRLLRGEELEPMHPWYRGFKGTIT 860
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 889 KSATKESGvSYTVTGIVEQVNETTIRVLELPIRKWTQDYKEFLEALLCGTeKIKEPSIKDYREHNTDTRVHFEISLSEEK 968
Cdd:PLN03128 861 EVSTSRSG-SYTVTGIIEQIGDTTIRITELPVRKWTQDYKEFLEALLTGT-KKKEPEIKDFKENHTDTTVHFTVTLSEEK 938
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 969 MAEALAEGLTKKFKLSTTISTSNMNLFDKDGHIRKYDTPEQILEDFYHIRLELYVKRKEVQVENLQYELLKLDNKVRFIL 1048
Cdd:PLN03128 939 MARALAEGLEKKFKLSTTISTSNMHLFDKDGKIKKYDSPEDILEEFFHLRLDLYVKRKEVLLENLEYELKKLDNKARFIL 1018
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 1049 GVVKGEIVVNNRKRAELLVELKTKGFTPFPKKAKASDLPVVGGDGSdvEADDEEKLNKGVRAGDYEYLLSMPIGTLTLEK 1128
Cdd:PLN03128 1019 AVVKGEIVVNNRKRAELLAELEEKGFDKFPKTAKISETNVVGDRDG--EASEEEEASDNELAKSYDYLLGMPISSLTLEK 1096
|
1130 1140 1150
....*....|....*....|....*....|....*....
gi 1376976423 1129 VQQLCNERDKLEGDVEELKKCTPKDLWEKDLDNFLEQLT 1167
Cdd:PLN03128 1097 VDELRAERAKKETEVEELKKTTPEDLWRKDLDAFEEALD 1135
|
|
| PLN03237 |
PLN03237 |
DNA topoisomerase 2; Provisional |
12-1393 |
0e+00 |
|
DNA topoisomerase 2; Provisional
Pssm-ID: 215641 [Multi-domain] Cd Length: 1465 Bit Score: 2122.23 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 12 KTIEEIYQKKTPLEHVLLRPDTYVGSIEKHTQTLWVYEGGQLVNRAVTYVPGLYKIFDEILVNAADNKQRDPSMDAVKVT 91
Cdd:PLN03237 26 KTIEEMYQKKSQLEHILLRPDTYIGSIEKHTQTLWVYETDKMVQRSVTYVPGLYKIFDEILVNAADNKQRDPKMDSLRVV 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 92 ISVEQNTISVYNNGDGVPVEVHNEQGVYVPEMIFGHLLTSSNYDDNEKKTTGGRNGYGAKLANIFSTEFVIETADGKRGK 171
Cdd:PLN03237 106 IDVEQNLISVYNNGDGVPVEIHQEEGVYVPEMIFGHLLTSSNYDDNEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRQK 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 172 KYKQVFSNNMSAKSEPAISSCKSNENWTKVTFKPDLAKFHMTYLEEDVVALMSKRVLDIAGCLGRTVKVELNGQKLPVKT 251
Cdd:PLN03237 186 KYKQVFSNNMGKKSEPVITKCKKSENWTKVTFKPDLAKFNMTHLEDDVVALMKKRVVDIAGCLGKTVKVELNGKRIPVKS 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 252 FSDYVGLYLASAQKGKEETLPRIYERANDRWEVCVSLSDGQFQQVSFVNSIATIRGGTHVQHVSEQIVSHIQEIVNKKNK 331
Cdd:PLN03237 266 FSDYVDLYLESANKSRPENLPRIYEKVNDRWEVCVSLSEGQFQQVSFVNSIATIKGGTHVDYVTNQIANHVMEAVNKKNK 345
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 332 NANVKGFQIRNHLWVFVNSLIDNPAFDSQTKETLTTRQTSFGSKCELSPEFLKKVSKCGVVDNVLSWADFKQSKELKKND 411
Cdd:PLN03237 346 NANIKAHNVKNHLWVFVNALIDNPAFDSQTKETLTLRQSSFGSKCELSEDFLKKVMKSGIVENLLSWADFKQSKELKKTD 425
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 412 GAKRQRLTGIAKLDDANDAGGKNSEACTLILTEGDSAKALAvssvfalsafltfcclqMSGISVVGRNHYGVFPLRGKLL 491
Cdd:PLN03237 426 GAKTTRVTGIPKLEDANEAGGKNSEKCTLILTEGDSAKALA-----------------VAGLSVVGRNYYGVFPLRGKLL 488
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 492 NVREATHKQIMDNAEITSIKQILGLQQGKGYENTKSLRYGHLMIMTDQDHDGSHIKGLIINFIHTFWPSLLKVPGFLVEF 571
Cdd:PLN03237 489 NVREASHKQIMNNAEIENIKQILGLQHGKQYESVKSLRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKVPSFLVEF 568
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 572 ITPIVKATHKNGKVLSFYTMPEYESWKESLRGETKGWSIKYYKGLGTSTAKEGKEYFRDLVKHKKDFAWDNDEDGDSIEL 651
Cdd:PLN03237 569 ITPIVKATRRGKKVLSFYSMPEYEEWKESLGGNATGWSIKYYKGLGTSTAKEGKEYFKNLGKHKKDFVWEDEQDGDAIEL 648
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 652 AFSKKKTEARKIWLRGYQPGTFLDQTQRVITYSDFINKELILFSLADLARSVPSMVDGLKPGQRKILFAAFKRNFTSQAK 731
Cdd:PLN03237 649 AFSKKKIEARKNWLRQYEPGTHLDQTQKDVKYSDFVNKELILFSMADLQRSIPSMVDGLKPGQRKILFCSFKRNFVKEAK 728
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 732 VAQFSGYVSEHSAYHHGEQSLASTIIGMAQNFVGSNNINILAPIGQFGTRSQGGKDHASARYIYTSLTPLTRTIFPKPDD 811
Cdd:PLN03237 729 VAQLSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRLQGGKDHASARYIFTRLSPITRFLFPKDDD 808
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 812 ILLNFLREDGQSIEPFWYAPILPMVLVNGSEGIGTGWSTFVPNYNPRDIVTNLKHLLRDEQLEPMDPWYKGFKGTIVKSA 891
Cdd:PLN03237 809 ILLDYLNEDGQSIEPTWYMPIIPTVLVNGAEGIGTGWSTFIPNYNPRDIVANIRRLLNGESMEPMHPWYRGFKGTIEKTA 888
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 892 TKESGVSYTVTGIVEQVNETTIRVLELPIRKWTQDYKEFLEALLCGTEKIKEPSIKDYREHNTDTRVHFEISLSEEKMAE 971
Cdd:PLN03237 889 SKEGGCTYTITGLYEEVDETTLRITELPIRRWTDDYKEFLESLKTDNNKNKDPFIKDVKAYNDDTTVHFEVILSEENMLA 968
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 972 ALAEGLTKKFKLSTTISTSNMNLFDKDGHIRKYDTPEQILEDFYHIRLELYVKRKEVQVENLQYELLKLDNKVRFILGVV 1051
Cdd:PLN03237 969 AKQEGLLKKFKLTTTISTSNMHLFDSKGVIKKYDTPEQILEEFFHLRLEYYEKRKEVLLKNLEFELLKLENKVRFILAVV 1048
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 1052 KGEIVVNNRKRAELLVELKTKGFTPFPKKAKASDLPVVGGDGSDVEADDEEKL--NKGVRAGDYEYLLSMPIGTLTLEKV 1129
Cdd:PLN03237 1049 DGEIIVNNRKKADLVEELRQKGFTPFPKKAKSVEAAVAGATDDAAEEEEEIDVssSSGVRGSDYDYLLSMAIGTLTLEKV 1128
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 1130 QQLCNERDKLEGDVEELKKCTPKDLWEKDLDNFLEQLTAQELEEEKEDELELKQ-----MAKEGAAIFKRAAAGRKPAAK 1204
Cdd:PLN03237 1129 QELCADRDKLNIEVEDLKKTTPKSLWLKDLDALEKELDKLDKEDAKAEEAREKLqraaaRGESGAAKKVSRQAPKKPAPK 1208
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 1205 AKTADKENAVKPTKKATAATKASN------------ASKKAAKPVELDSEEEYFNTSLQDRLAAYAKGKGP--------- 1263
Cdd:PLN03237 1209 KTTKKASESETTEETYGSSAMETEnvaevvkpkgraGAKKKAPAAAKEKEEEDEILDLKDRLAAYNLDSAPaqsakmeet 1288
|
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 1264 -----------------------LTEDNSMEDAVKEVSPPT-------KPNA--PKAAP---VAKKRA-NTKASKASKAT 1307
Cdd:PLN03237 1289 vkavparraaarkkplasvsvisDSDDDDDDFAVEVSLAERlkkkggrKPAAanKKAAKppaAAKKRGpATVQSGQKLLT 1368
|
1370 1380 1390 1400 1410 1420 1430 1440
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 1308 EDVAAHD----SPDAKVRKVRASPFNKKSGSVIPQLAKLSIE----------AEADSDVEAAPQARPKrRAARPAVHYIE 1373
Cdd:PLN03237 1369 EMLKPAEaigiSPEKKVRKMRASPFNKKSGSVLGRAATNKETessenvsgssSSEKDEIDVSAKPRPQ-RANRKQTTYVL 1447
|
1450 1460
....*....|....*....|
gi 1376976423 1374 SDTEEDkaaSEDISDFEDEG 1393
Cdd:PLN03237 1448 SDSESE---SADDSDFDDDE 1464
|
|
| PTZ00108 |
PTZ00108 |
DNA topoisomerase 2-like protein; Provisional |
12-1395 |
0e+00 |
|
DNA topoisomerase 2-like protein; Provisional
Pssm-ID: 240271 [Multi-domain] Cd Length: 1388 Bit Score: 1805.01 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 12 KTIEEIYQKKTPLEHVLLRPDTYVGSIEKHTQTLWVY--EGGQLVNRAVTYVPGLYKIFDEILVNAADNKQRDPS---MD 86
Cdd:PTZ00108 4 KTVEERYQKKTQIEHILLRPDTYIGSIETQTEDMWVYdeEKNRMVYKTITYVPGLYKIFDEILVNAADNKARDKGghrMT 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 87 AVKVTISVEQNTISVYNNGDGVPVEVHNEQGVYVPEMIFGHLLTSSNYDDNEKKTTGGRNGYGAKLANIFSTEFVIETAD 166
Cdd:PTZ00108 84 YIKVTIDEENGEISVYNDGEGIPVQIHKEHKIYVPEMIFGHLLTSSNYDDTEKRVTGGRNGFGAKLTNIFSTKFTVECVD 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 167 GKRGKKYKQVFSNNMSAKSEPAISSCKSNENWTKVTFKPDLAKFHMTYLEEDVVALMSKRVLDIAGCLGrTVKVELNGQK 246
Cdd:PTZ00108 164 SKSGKKFKMTWTDNMSKKSEPRITSYDGKKDYTKVTFYPDYAKFGMTEFDDDMLRLLKKRVYDLAGCFG-KLKVYLNGER 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 247 LPVKTFSDYVGLYLASAQKGKEETLPRIYERANDRWEVCVSLSDGQFQQVSFVNSIATIRGGTHVQHVSEQIVSHIQE-I 325
Cdd:PTZ00108 243 IAIKSFKDYVDLYLPDGEEGKKPPYPFVYTSVNGRWEVVVSLSDGQFQQVSFVNSICTTKGGTHVNYILDQLISKLQEkA 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 326 VNKKNKNANVKGFQIRNHLWVFVNSLIDNPAFDSQTKETLTTRQTSFGSKCELSPEFLKKVSKCGVVDNVLSWADFKQSK 405
Cdd:PTZ00108 323 KKKKKKGKEIKPNQIKNHLWVFVNCLIVNPSFDSQTKETLTTKPSKFGSTCELSEKLIKYVLKSPILENIVEWAQAKLAA 402
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 406 EL-KKNDGAKRQRLTGIAKLDDANDAGGKNSEACTLILTEGDSAKALAvssvfalsafltfcclqMSGISVVGRNHYGVF 484
Cdd:PTZ00108 403 ELnKKMKAGKKSRILGIPKLDDANDAGGKNSEECTLILTEGDSAKALA-----------------LAGLSVVGRDYYGVF 465
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 485 PLRGKLLNVREATHKQIMDNAEITSIKQILGLQQGKGYENTKSLRYGHLMIMTDQDHDGSHIKGLIINFIHTFWPSLLKV 564
Cdd:PTZ00108 466 PLRGKLLNVRDASLKQLMNNKEIQNLFKILGLDIGKKYEDPKGLRYGSLMIMTDQDHDGSHIKGLLINMIHHFWPSLLKN 545
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 565 PGFLVEFITPIVKATHKNGKVLSFYTMPEYESWKESLrgETKGWSIKYYKGLGTSTAKEGKEYFRDLVKHKKDFAWDNDE 644
Cdd:PTZ00108 546 PGFLKEFITPIVKATKKGNQVISFFTIPDFEKWKQTV--GLKGWKIKYYKGLGTSTDKEGKEYFSNIDKHRIRFVYVDDS 623
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 645 DGDSIELAFSKKKTEARKIWLRGYQPGTFLDQTQRVITYSDFINKELILFSLADLARSVPSMVDGLKPGQRKILFAAFKR 724
Cdd:PTZ00108 624 DDDSIDLAFSKKRVEDRKEWITNYKGGTYVDHSKKKLTYSDFVNKELILFSIADNERSIPSLVDGLKPGQRKILFACFKR 703
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 725 NFTSQAKVAQFSGYVSEHSAYHHGEQSLASTIIGMAQNFVGSNNINILAPIGQFGTRSQGGKDHASARYIYTSLTPLTRT 804
Cdd:PTZ00108 704 NLKNEIKVAQLSGYVSEHSAYHHGEQSLQQTIVGMAQNFVGSNNINLLYPCGQFGSRLQGGKDHAAARYIFTKLSKITRY 783
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 805 IFPKPDDILLNFLREDGQSIEPFWYAPILPMVLVNGSEGIGTGWSTFVPNYNPRDIVTNLKHLLRDEQLEPMDPWYKGFK 884
Cdd:PTZ00108 784 IFPEEDDPILDYLEDDGQSVEPFYYVPIIPMVLVNGAEGIGTGFSTSIPNYNPLDIIDNLRRRLNGEEVRPLVPWYRGFK 863
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 885 GTIvksaTKESGVSYTVTGIVEQVNETTIRVLELPIRKWTQDYKEFLEAllcgTEKIKEPSIKDYREHNTDTRVHFEISL 964
Cdd:PTZ00108 864 GTI----ERNPKGKFISKGIYEKVPDGTVEITELPIGKWTEDYKEFLES----ETLKEKDVIVDYRDYSTANTVHFTVKL 935
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 965 SEEKMAEALAEGLTKKFKLSTTISTSNMNLFDKDGHIRKYDTPEQILEDFYHIRLELYVKRKEVQVENLQYELLKLDNKV 1044
Cdd:PTZ00108 936 NDGVLEQWEEEGIEKVFKLKSTISTTNMVLFDENGKIKKYSDALDILKEFYLVRLDLYKKRKEYLLGKLERELARLSNKV 1015
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 1045 RFILGVVKGEIVVNNRKRAELLVELKTKGFTPFP----KKAKASDLPVVGGDGSDVEADDEEKLNKGVRAGDYEYLLSMP 1120
Cdd:PTZ00108 1016 RFIKHVINGELVITNAKKKDLVKELKKLGYVRFKdiikKKSEKITAEEEEGAEEDDEADDEDDEEELGAAVSYDYLLSMP 1095
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 1121 IGTLTLEKVQQLCNERDKLEGDVEELKKCTPKDLWEKDLDNFLEQLTAQELEEEKEDELELKQMAKEGAAIFKRA----- 1195
Cdd:PTZ00108 1096 IWSLTKEKVEKLNAELEKKEKELEKLKNTTPKDMWLEDLDKFEEALEEQEEVEEKEIAKEQRLKSKTKGKASKLRkpklk 1175
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 1196 ----AAGRKPAAKAKTADKENAVKPTKKATAATKASNASKKAAKPVELDSEEEYFN------------TSLQDRLAAYAK 1259
Cdd:PTZ00108 1176 kkekKKKKSSADKSKKASVVGNSKRVDSDEKRKLDDKPDNKKSNSSGSDQEDDEEQktkpkkssvkrlKSKKNNSSKSSE 1255
|
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 1260 GKGPLTEDNSMEDAVKEVSPPTKPNAPKAAPVAKKRANTKASKASKATEDvaAHDSPDAKVRKVRASPFNKKSGSvipql 1339
Cdd:PTZ00108 1256 DNDEFSSDDLSKEGKPKNAPKRVSAVQYSPPPPSKRPDGESNGGSKPSSP--TKKKVKKRLEGSLAALKKKKKSE----- 1328
|
1370 1380 1390 1400 1410
....*....|....*....|....*....|....*....|....*....|....*.
gi 1376976423 1340 AKLSIEAEADSDVEAAPQARPKRRAARPAVHYIESDTEEDKAASEDISDFEDEGSE 1395
Cdd:PTZ00108 1329 KKTARKKKSKTRVKQASASQSSRLLRRPRKKKSDSSSEDDDDSEVDDSEDEDDEDD 1384
|
|
| TOP2c |
smart00433 |
TopoisomeraseII; Eukaryotic DNA topoisomerase II, GyrB, ParE |
63-668 |
0e+00 |
|
TopoisomeraseII; Eukaryotic DNA topoisomerase II, GyrB, ParE
Pssm-ID: 214659 [Multi-domain] Cd Length: 594 Bit Score: 746.30 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 63 GLYKIFDEILVNAADNKQRDPsMDAVKVTISVEqNTISVYNNGDGVPVEVHNEQGVYVPEMIFGHLLTSSNYDDNEKKTT 142
Cdd:smart00433 1 GLHHLVDEIVDNAADEALAGY-MDTIKVTIDKD-NSISVEDNGRGIPVEIHPKEKKYAPEVIFTVLHAGGKFDDDAYKVS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 143 GGRNGYGAKLANIFSTEFVIETADGkrGKKYKQVFSNNMSAKSEPAISSCkSNENWTKVTFKPDLAKFHMTylEEDVVAL 222
Cdd:smart00433 79 GGLHGVGASVVNALSTEFEVEVARD--GKEYKQSFSNNGKPLSEPKIIGD-TKKDGTKVTFKPDLEIFGMT--TDDDFEL 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 223 MSKRVLDIAGCLgRTVKVELNGQK-------LPVKTFSDYVGLYLASAQKGKEETLPRIYERANDRWEVCVSLSDG-QFQ 294
Cdd:smart00433 154 LKRRLRELAFLN-KGVKITLNDERsdeektfLFEGGIKDYVELLNKNKELLSPEPTYIEGEKDNIRVEVAFQYTDGySEN 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 295 QVSFVNSIATIRGGTHVQHVSEQIVSHIQEIVNKKNKNANVK--GFQIRNHLWVFVNSLIDNPAFDSQTKETLTTRQTSF 372
Cdd:smart00433 233 IVSFVNNIATTEGGTHENGFKDALTRVINEYAKKKKKLKEKNikGEDVREGLTAFISVKIPEPQFEGQTKEKLGTSEVRF 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 373 G-----SKCELSPEFLKKVSKCGVVDNVLSWADFK-QSKELKKNDGAK-RQRLTGIAKLDDANDAGGKNseaCTLILTEG 445
Cdd:smart00433 313 GvekivSECLLSFLEENPVEASKIVEKVLLAAKARaAAKKARELTRKKkLSSISLPGKLADASSAGPKK---CELFLVEG 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 446 DSAKALAVSsvfALSafltfcclqmsgisvvgRNHYGVFPLRGKLLNVREATHKQIMDNAEITSIKQILGLQQGKGYeNT 525
Cdd:smart00433 390 DSAGGSAKS---GRD-----------------RDFQAILPLRGKILNVEKASLDKILKNEEIQALITALGLGIGKDF-DI 448
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 526 KSLRYGHLMIMTDQDHDGSHIKGLIINFIHTFWPSLLKVpGFLVEFITPIVKATHKNG-KVLSFYTMPEYESWKESLRGE 604
Cdd:smart00433 449 EKLRYGKIIIMTDADVDGSHIKGLLLTFFYRYMPPLIEA-GFVYIAIPPLYKVTKGKKkYVYSFYSLDEYEKWLEKTEGN 527
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1376976423 605 TKGWSIKYYKGLGTSTAKEGKEYFRDLVKHKKDFAW-DNDEDGDSIELAFSKKKTEARKIWLRGY 668
Cdd:smart00433 528 KSKYEIQRYKGLGEMNADQLWETTMDPERRTLLFVTlDDADEADLIFSALMGDKVEPRKEWIEEN 592
|
|
| TOP4c |
smart00434 |
DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC |
681-1155 |
7.09e-174 |
|
DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC
Pssm-ID: 214660 [Multi-domain] Cd Length: 444 Bit Score: 524.82 E-value: 7.09e-174
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 681 ITYSDFINKELILFSL-ADLARSVPSMVDGLKPGQRKILFAAFKRNFTSQ-AKVAQFSGYVSEHSAYH-HGEQSLASTII 757
Cdd:smart00434 1 IDIEDFINKEYLDYSMsVINGRAIPDVRDGLKPVQRRILYAMFKRGLTPDePKVKSARGVGDVMGKYHpHGDSSLYDTIV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 758 GMAQNFVgsNNINILAPIGQFGTRsQGGKDHASARYIYTSLTPLTRTIFPKPDDILLNFLRE-DGQSIEPFWYAPILPMV 836
Cdd:smart00434 81 RMAQDFS--NNYPLLDGQGNFGSR-LDGDDAAAMRYTETRLSPLARLLLPDIDKDTVDFVPNyDGQEIEPTVLPPIIPNL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 837 LVNGSEGIGTGWSTFVPNYNPRDIVTNLKHLLRDEQLEP----MDPWYKGFKGTIVKSATKesgvSYTVTGIVEQVNETT 912
Cdd:smart00434 158 LVNGSSGIAVGMATNIPPHNLREVIDAVRRLIDNPDASIdelmMIPWGPDFPTGGEIVGPG----KYVVRGKIEIEDDNT 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 913 IRVLELPIRKWTQDYKEFLEALLcgTEKIKEPSIKDYREHNTDTRVHFEISLSEEKMAEALAEGLTKKFKLSTTISTSNM 992
Cdd:smart00434 234 IVITELPYQVNTADLIEKIAELV--KDKKIEGIIDVRDESHDRTGVRIVIELKRGAMAEVVLNGLYKLTKLQTTFSINML 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 993 NLFDkDGHIRKYDTPEqILEDFYHIRLELYVKRKEVQVENLQyELLKLDNKVRFILGVVKGEIVVNNRKRAELLVELKTK 1072
Cdd:smart00434 312 ALFD-NGRPKKYNLKE-ILKEFLDHRLEVYTRRKEYLLGKLE-AERLHILEGLFIALSIIDEIIVLIRSSKDLAKEAKEK 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 1073 GFTPFpkkakasdlpvvggdgsdveADDEEklnkgvragDYEYLLSMPIGTLTLEKVQQLCNERDKLEGDVEELKKCTPK 1152
Cdd:smart00434 389 LMERF--------------------ELSEI---------QADAILDMRLRRLTKLEVEKLEKELKELEKEIEDLEKILAS 439
|
...
gi 1376976423 1153 DLW 1155
Cdd:smart00434 440 EEW 442
|
|
| TOP4c |
cd00187 |
DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), ... |
700-1162 |
1.82e-149 |
|
DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA topology by catalysing the concerted breakage and rejoining of DNA strands during normal cellular growth.
Pssm-ID: 238111 [Multi-domain] Cd Length: 445 Bit Score: 460.88 E-value: 1.82e-149
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 700 ARSVPSMVDGLKPGQRKILFAAFKRNFTSQA---KVAQFSGYVSEHSaYHHGEQSLASTIIGMAQNFvgSNNINILAPIG 776
Cdd:cd00187 2 GRALPDVRDGLKPVQRRILYAMFKRGLTPDKpekKVARLVGDVAGKY-HPHGDSSLYDTIVRMAQDF--SNNIPLLDPQG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 777 QFGTRsqGGKDHASARYIYTSLTPLTRTIFPKPDDILLNFLRE-DGQSIEPFWYAPILPMVLVNGSEGIGTGWSTFVPNY 855
Cdd:cd00187 79 NFGSR--DGDDAAAMRYTETRLSPIARLLLPDIDDPTVDFVPNyDGQEVEPEVLPPIFPNLLVNGSSGIAVGMATNIPPH 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 856 NPRDIVTNLKHLLRDEQLE-------PMDPWYKGFkGTI-----VKSATKESGVSYTVTGIVEQV---NETTIRVLELPI 920
Cdd:cd00187 157 NLREVIDALRALIDNPEASidelmeiIKGPDFPTG-GIIegragIREAYETGRGRYIIRGKYEIEddeGRNTIEITELPY 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 921 RKWTQDYKEFLEALLcgTEKiKEPSIKDYREHNTDTRVHFEISLSEEKMAEALAEGLTKKFKLSTTISTsNMNLFDKDGH 1000
Cdd:cd00187 236 QVNKAKLKEKIAELV--KDK-KIEGISDVRDESDREGIRFVIELKRGAMAEVVLNGLYKVTKLQTTFGI-NMVAFDPNGR 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 1001 IRKYdTPEQILEDFYHIRLELYVKRKEVQVENLQYELLKLDNKVRFILGVvkgeIVVNNRKR------AELLVELKTKGF 1074
Cdd:cd00187 312 PKKL-NLKEILQEFLDHRLEVYTRRKEYELGKAEARLHILEGLLKAILNI----DEVINLIRssdeakKALIEELEKLGF 386
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 1075 TPFpkkakasdlpvvggdgsdveaddeeklnkgvragDYEYLLSMPIGTLTLEKVQQLCNERDKLEGDVEELKKCT---- 1150
Cdd:cd00187 387 SEI----------------------------------QADAILDMRLRRLTKLEREKLLKELKELEAEIEDLEKILasee 432
|
490
....*....|...
gi 1376976423 1151 -PKDLWEKDLDNF 1162
Cdd:cd00187 433 rPKDLWKEELDEF 445
|
|
| DNA_topoisoIV |
pfam00521 |
DNA gyrase/topoisomerase IV, subunit A; |
701-1160 |
3.28e-146 |
|
DNA gyrase/topoisomerase IV, subunit A;
Pssm-ID: 459843 [Multi-domain] Cd Length: 432 Bit Score: 451.62 E-value: 3.28e-146
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 701 RSVPSMVDGLKPGQRKILFAAFK-RNFTSQ-AKVAQFSGYVseHSAYH-HGEQSLASTIIGMAQNFVGsnNINILAPIGQ 777
Cdd:pfam00521 1 RAIPDVRDGLKPVQRRILYAMFElLNLDKPyKKVARLVGDV--MGKYHpHGDASLYDAIVRMAQDFVG--NIPLLDGQGN 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 778 FGTRSQGGKDhASARYIYTSLTPLTRTIFPKPDDILLNFLRE-DGQSIEPFWYAPILPMVLVNGSEGIGTGWSTFVPNYN 856
Cdd:pfam00521 77 FGSRIDGDKD-AAMRYTETRLSKIARELFPDIDDDTVDYVPNyDGTEVEPTVLPPIIPNLLVNGAEGIAVGMATNIPPHN 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 857 PRDIVTNLKHLLRDEQLE-----PMDPWYKGFKGTIVKSATKE---SGV-SYTVTGIVEQVNETTIRVLELPIRKWTQDY 927
Cdd:pfam00521 156 LREIIDALIALLDGPEATllmkyIMGPDFPTGGGIIGKGGIKEaykTGRgKITVRAKVEIEDRKTIVITELPYGVWTSDL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 928 KEFLEALLcGTEKIKEpsIKDYREHnTDTRVHFEISLSEEKMAEALAEGLTKKFKLSTTISTSNMNLFDkdgHIRKYDTP 1007
Cdd:pfam00521 236 IEKIEELV-KNGKIKG--ISDIRDE-SDRGVRIVIELKRGADPEVVLNDLYKKTKLQTSFSTNNLVLFD---GGPKYLGL 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 1008 EQILEDFYHIRLELYVKRKEVQVENLQYELLKLD------NKVRFILGVVKGEIvVNNRKRAELLVELKTKgftpfpkka 1081
Cdd:pfam00521 309 KEILKEFLDHRLEVYERRKEYLLEKLEERLHILEgllialNNIDFVIEIIRGSI-DRKKAKKNLIEELSEI--------- 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 1082 kasdlpvvggdgsdveaddeeklnkgvragDYEYLLSMPIGTLTLEKVQQLCNERDKLEGDVEELKKCTPK-----DLWE 1156
Cdd:pfam00521 379 ------------------------------QADYLLDMRLRRLTKEEVDKLLEEIDELEKEIAELEKLLASekklnDLWI 428
|
....
gi 1376976423 1157 KDLD 1160
Cdd:pfam00521 429 EELD 432
|
|
| HATPase_TopII-like |
cd16930 |
Histidine kinase-like ATPase domain of eukaryotic topoisomerase II; This family includes the ... |
60-206 |
5.03e-91 |
|
Histidine kinase-like ATPase domain of eukaryotic topoisomerase II; This family includes the histidine kinase-like ATPase (HATpase) domains of human topoisomerase IIA (TopIIA) and TopIIB, Saccharomyces cerevisae TOP2p, and related proteins. These proteins catalyze the passage of DNA double strands through a transient double-strand break in the presence of ATP.
Pssm-ID: 340407 [Multi-domain] Cd Length: 147 Bit Score: 290.39 E-value: 5.03e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 60 YVPGLYKIFDEILVNAADNKQRDPSMDAVKVTISVEQNTISVYNNGDGVPVEVHNEQGVYVPEMIFGHLLTSSNYDDNEK 139
Cdd:cd16930 1 YVPGLYKIFDEILVNAADNKQRDKSMTCIKVTIDPENNEISVWNNGKGIPVVIHKEEKIYVPEMIFGHLLTSSNYDDDEK 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1376976423 140 KTTGGRNGYGAKLANIFSTEFVIETADGKRGKKYKQVFSNNMSAKSEPAISSCKSNENWTKVTFKPD 206
Cdd:cd16930 81 KVTGGRNGYGAKLCNIFSTEFTVETADSESKKKFKQTWTNNMGKASEPKITPYEKGKDYTKVTFKPD 147
|
|
| 52 |
PHA02592 |
DNA topisomerase II medium subunit; Provisional |
681-1163 |
2.63e-80 |
|
DNA topisomerase II medium subunit; Provisional
Pssm-ID: 222896 [Multi-domain] Cd Length: 439 Bit Score: 271.93 E-value: 2.63e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 681 ITYSDFINKELILFSLADL-ARSVPSMVDGLKPGQRKILFAAF---KRNFTSQAKVAQFSGYVSEHSaYHHGEQSLASTI 756
Cdd:PHA02592 6 RSLKSIVNNEALEYAMYTVeERAIPNLIDGLKPVQRFVIHRALeyaKGNKEKFDKVAAIAGGVADLG-YHHGETSAQDAG 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 757 IGMAQNFvgSNNINILAPIGQFGTRSqgGKDHASARYIYTSLTPLTRTIFpkpDDILLNFLREDGQSIEPFWYAPILPMV 836
Cdd:PHA02592 85 ALMANTW--NNNIPLLDGQGNFGSRL--VQKAAAARYIFARVHDNFRKIY---KDEDLAPVHEDPEHIPPAFYLPIIPMV 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 837 LVNGSEGIGTGWSTFVPNYNPRDIVTNLKHLLRDEQLEPMDPWYKGFKGTIVKSATKesgvSYTVTGIVEQVNETTIRVL 916
Cdd:PHA02592 158 LLNGVSGIATGYATNILPHSPKSVIKAVLAALNGKDITEPKVQFPEFKGEVVEIEPG----SYEIRGTYELNGKTKLHIT 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 917 ELPIrKWtqDYKEFLEALLCGTEKIKEPSIKDYREHNTDtrvhFEISLSEEKMAEALAEGLTKKFKLSTTiSTSNMNLFD 996
Cdd:PHA02592 234 EIPV-KY--DRETYVAVLDPLEEKGKIVSYDDCTEDGFR----FKVTLKREENEEATHEKIMKDFGLIER-VSQNITVIN 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 997 KDGHIRKYDTPEQILEDFYHIRLELYVKRKEVQVENLQYELLKLDNKVRFILGVVKGEIVVNNRKRAELLVELKTKgftp 1076
Cdd:PHA02592 306 ENGKLKVYENAEDLIRDFVEIRKTYVQKRIQYEIKETEEAFDLALAKAEFIKRVIAGEIVLQGKTRSELTEELSDN---- 381
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 1077 fpkkakasdlpvvggdgsdveADDEEKLNKgvragdyeyLLSMPIGTLTLEKVQQLCNERDKLEGDVEELKKCTPKDLWE 1156
Cdd:PHA02592 382 ---------------------KDFGEYADK---------LVAMNIYSMTSDEREKLQKEAEELEKEHEYWKKTTAKKEYI 431
|
....*..
gi 1376976423 1157 KDLDNFL 1163
Cdd:PHA02592 432 KDLEELK 438
|
|
| TOPRIM_TopoIIA |
cd03365 |
TOPRIM_TopoIIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the ... |
438-573 |
6.09e-78 |
|
TOPRIM_TopoIIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands of the duplex DNA to remove (relax) both positive and negative supercoils in DNA. These enzymes covalently attach to the 5' ends of the cut DNA, separate the free ends of the cleaved strands, pass another region of the duplex through this gap, then rejoin the ends. These proteins also catenate/ decatenate duplex rings. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). This glutamate and two aspartates, cluster together to form a highly acid surface patch. The conserved glutamate may act as a general base in strand joining and as a general acid in strand cleavage by topisomerases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173785 [Multi-domain] Cd Length: 120 Bit Score: 252.61 E-value: 6.09e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 438 CTLILTEGDSAKALAVSsvfalsafltfcclqmsGISVVGRNHYGVFPLRGKLLNVREATHKQIMDNAEITSIKQILGLQ 517
Cdd:cd03365 1 CTLILTEGDSAKALAVA-----------------GLSVVGRDYYGVFPLRGKLLNVREASHKQIMENAEIQNIKKILGLQ 63
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1376976423 518 QGKG-YENTKSLRYGHLMIMTDQDHDGSHIKGLIINFIHTFWPSLLKVPGFLVEFIT 573
Cdd:cd03365 64 HGKSdYESTKSLRYGRLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKIPGFLVEFIT 120
|
|
| 39 |
PHA02569 |
DNA topoisomerase II large subunit; Provisional |
22-667 |
1.83e-77 |
|
DNA topoisomerase II large subunit; Provisional
Pssm-ID: 177398 [Multi-domain] Cd Length: 602 Bit Score: 268.93 E-value: 1.83e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 22 TPLEHVLLRPDTYVGSIEKHTQTLWVYegGQLvnRAVTYVPGLYKIFDEILVNAADNKQRDPSMDAVKVTISVEQNTISV 101
Cdd:PHA02569 8 SDREHILKRPGMYIGSVAYEAHERFLF--GKF--TQVEYVPGLVKIIDEIIDNSVDEAIRTNFKFANKIDVTIKNNQVTV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 102 YNNGDGVPVE-VHNEQGVYVPEMIFGHLLT--SSNYDDNEKKtTGGRNGYGAKLANIFSTEFVIETADGKRgkKYKQVFS 178
Cdd:PHA02569 84 SDNGRGIPQAmVTTPEGEEIPGPVAAWTRTkaGSNFDDTNRV-TGGMNGVGSSLTNFFSVLFIGETCDGKN--EVTVNCS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 179 NNMSAKSepaISSCKSNENWTKVTFKPDLAKFHMTYLEEDVVALMSKRVLDIAgCLGRTVKVELNGQKLPVKtFSDYVGL 258
Cdd:PHA02569 161 NGAENIS---WSTKPGKGKGTSVTFIPDFSHFEVNGLDQQYLDIILDRLQTLA-VVFPDIKFTFNGKKVSGK-FKKYAKQ 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 259 YlasaqkgKEETLprIYEraNDRWEVCVSLSDGQFQQVSFVNSIATIRGGTHVQHVSEQIVSHIQ---------EIVNKK 329
Cdd:PHA02569 236 F-------GDDTI--VQE--NDNVSIALAPSPDGFRQLSFVNGLHTKNGGHHVDCVMDDICEELIpmikkkhkiEVTKAR 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 330 NKNANVKGFQIRNhlwvfvnslIDNPAFDSQTKETLTTRQTSFGSKCELSpefLKKVSKC-----GVVDNVLSWADFKQ- 403
Cdd:PHA02569 305 VKECLTIVLFVRN---------MSNPRFDSQTKERLTSPFGEIRNHIDLD---YKKIAKQilkteAIIMPIIEAALARKl 372
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 404 ----SKELKKNDGAKRqrlTGIAKLDDANDAgGKNSEAcTLILTEGDSakalavssvfALSAFltfcclqmsgISVVGRN 479
Cdd:PHA02569 373 aaekAAETKAAKKAKK---AKVAKHIKANLI-GKDAET-TLFLTEGDS----------AIGYL----------IEVRDEE 427
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 480 HYGVFPLRGKLLNVREATHKQIMDNAEITSIKQILGLQQGKGYENTKslrYGHLMIMTDQDHDG-SHIKGLIINFIHTfW 558
Cdd:PHA02569 428 LHGGYPLRGKVLNTWGMSYADILKNKELFDICAITGLVLGEKAENMN---YKNIAIMTDADVDGkGSIYPLLLAFFSR-W 503
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 559 PSLLKVPGflVEFI-TPIVKAThkNGKVLS-FYTMPEYESWKESLrgetKGWSIKYYKGLGTSTAKEGKEYFRDLVKHKK 636
Cdd:PHA02569 504 PELFEQGR--IRFVkTPVIIAQ--VGKETKwFYSLDEFEKAKDSL----KKWSIRYIKGLGSLRKSEYRRVINNPVYDVV 575
|
650 660 670
....*....|....*....|....*....|.
gi 1376976423 637 DFawdNDEDGDSIELAFSkKKTEARKIWLRG 667
Cdd:PHA02569 576 VL---PDDWKELFEMLFG-DDADLRKDWMSQ 602
|
|
| TOPRIM_C |
pfam16898 |
C-terminal associated domain of TOPRIM; TOPRIM_C is found as the C-terminal extension of the ... |
571-699 |
2.58e-75 |
|
C-terminal associated domain of TOPRIM; TOPRIM_C is found as the C-terminal extension of the TOPRIM domain, pfam01751 in metazoa.
Pssm-ID: 465302 [Multi-domain] Cd Length: 127 Bit Score: 245.12 E-value: 2.58e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 571 FITPIVKATHKNgKVLSFYTMPEYESWKESLrGETKGWSIKYYKGLGTSTAKEGKEYFRDLVKHKKDFAWDNDEDGDSIE 650
Cdd:pfam16898 1 FITPIVKVTKGK-EVISFFSLPEYEEWKEST-PNLKGWKIKYYKGLGTSTSEEAKEYFSNLDKHRKEFKYLGDDDDEAID 78
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1376976423 651 LAFSKKKTEARKIWLRGYQPGTFLDQTQRVITYSDFINKELILFSLADL 699
Cdd:pfam16898 79 LAFSKKKADDRKEWLRNFNPGTYLDHSTKEISYSDFINKELILFSMADN 127
|
|
| TopoIIA_Trans_ScTopoIIA |
cd03481 |
TopoIIA_Trans_ScTopoIIA: Transducer domain, having a ribosomal S5 domain 2-like fold, of the ... |
250-401 |
1.98e-73 |
|
TopoIIA_Trans_ScTopoIIA: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topo IIA. S. cerevisiae Topo IIA is a homodimer encoded by a single gene. The type IIA enzymes are the predominant form of topoisomerase and are found in some bacteriophages, viruses and archaea, and in all bacteria and eukaryotes. All type IIA topoisomerases are related to each other at amino acid sequence level, though their oligomeric organization sometimes differs. TopoIIA enzymes cut both strands of the duplex DNA to remove (relax) both positive and negative supercoils in DNA. These enzymes covalently attach to the 5' ends of the cut DNA, separate the free ends of the cleaved strands, pass another region of the duplex through this gap, then rejoin the ends. TopoIIA enzymes also catenate/ decatenate duplex rings. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is known to be important in nucleotide hydrolysis and the transduction of structural signals from ATP-binding site to the DNA breakage/reunion regions of the enzymes.
Pssm-ID: 239563 [Multi-domain] Cd Length: 153 Bit Score: 241.04 E-value: 1.98e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 250 KTFSDYVGLYLASAQKGKEETLPRIYERANDRWEVCVSLSDGQFQQVSFVNSIATIRGGTHVQHVSEQIVSHIQE-IVNK 328
Cdd:cd03481 1 KSFKDYVKLYLKDANKEDGPPPPVVYEPVNDRWEVAVALSDGQFQQVSFVNSIATTKGGTHVDYVADQIVKKLDEvVKKK 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1376976423 329 KNKNANVKGFQIRNHLWVFVNSLIDNPAFDSQTKETLTTRQTSFGSKCELSPEFLKKVSKCGVVDNVLSWADF 401
Cdd:cd03481 81 NKGGINVKPFQVKNHLWIFVNCLIENPSFDSQTKETLTTKPKSFGSKCELSEKFLKKAVKSGIVESVLSWAKF 153
|
|
| PRK05559 |
PRK05559 |
DNA topoisomerase IV subunit B; Reviewed |
24-665 |
2.42e-58 |
|
DNA topoisomerase IV subunit B; Reviewed
Pssm-ID: 235501 [Multi-domain] Cd Length: 631 Bit Score: 213.81 E-value: 2.42e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 24 LEHVLLRPDTYVGSiekhTQTlwvyeggqlvnravtyvPGLYKIFDEILvnaaDNkqrdpSMD-AV-------KVTISvE 95
Cdd:PRK05559 19 LEPVRKRPGMYIGS----TDT-----------------RGLHHLVQEVI----DN-----SVDeALaghgkriEVTLH-A 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 96 QNTISVYNNGDGVPVEVHNEQGVYVPEMIFGHLLTSSNYDDNEKKTTGGRNGYGAKLANIFSTEFVIETadgKR-GKKYK 174
Cdd:PRK05559 68 DGSVSVRDNGRGIPVGIHPEEGKSGVEVILTKLHAGGKFSNKAYKFSGGLHGVGVSVVNALSSRLEVEV---KRdGKVYR 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 175 QVFSNNMSAKSEPAISSCKSNENWTKVTFKPD-----LAKFHMTYLEEdvvALMSKRVLdiagCLGrtVKVELNGQKLPV 249
Cdd:PRK05559 145 QRFEGGDPVGPLEVVGTAGKRKTGTRVRFWPDpkifdSPKFSPERLKE---RLRSKAFL----LPG--LTITLNDERERQ 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 250 KTFSDYvGL--YLASAQKGKEeTLPRIY------ERANDRWEVCVS-LSDGQFQQVSFVNSIATIRGGTHVQHVSEQIVS 320
Cdd:PRK05559 216 TFHYEN-GLkdYLAELNEGKE-TLPEEFvgsfegEAEGEAVEWALQwTDEGGENIESYVNLIPTPQGGTHENGFREGLLK 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 321 HIQEIVNKKNKNANVKGFQ---IRNHLwVFVNSL-IDNPAFDSQTKETLTTRQ-TSFGS---KCELSpEFL---KKVSKc 389
Cdd:PRK05559 294 AVREFAEKRNLLPKGKKLEgedVREGL-AAVLSVkIPEPQFEGQTKEKLGSREaRRFVSgvvKDAFD-LWLnqnPELAE- 370
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 390 GVVDNVLSWADF--KQSKELKKNDGAKRQRLTGiaKLddaNDAGGKNSEACTLILTEGDSAkalavssvfalsafltfcc 467
Cdd:PRK05559 371 KLAEKAIKAAQArlRAAKKVKRKKKTSGPALPG--KL---ADCTSQDPERTELFLVEGDSA------------------- 426
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 468 lqmSGISVVGRN--HYGVFPLRGKLLNVREATHKQIMDNAEITSIKQILGLQQGKGYeNTKSLRYGHLMIMTDQDHDGSH 545
Cdd:PRK05559 427 ---GGSAKQARDreFQAILPLRGKILNTWEASLDDVLANEEIHDIIVAIGIGPGDSF-DLEDLRYGKIIIMTDADVDGAH 502
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 546 IKGLIINFIHTFWPSllkvpgfLVE----FI--TPIVKATHKNGKvlsFYTMPEYE--SWKESLRGETKGWSIKYYKGLG 617
Cdd:PRK05559 503 IATLLLTFFYRHFPP-------LVEaghvYIalPPLYRVDKGKKK---IYALDEEEkeELLKKLGKKGGKPEIQRFKGLG 572
|
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|....*.
gi 1376976423 618 TSTAKEGKEYF-----RDLVKHKKDfawdndeDGDSIELAFSK---KKTEARKIWL 665
Cdd:PRK05559 573 EMNPDQLWETTmdpetRRLVRVTID-------DAEETEKLVDMlmgKKAEPRREWI 621
|
|
| TOPRIM_TopoIIA_like |
cd01030 |
TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain ... |
438-573 |
6.38e-57 |
|
TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands of the duplex DNA to remove (relax) both positive and negative supercoils in DNA. These enzymes covalently attach to the 5' ends of the cut DNA, separate the free ends of the cleaved strands, pass another region of the duplex through this gap, then rejoin the ends. These proteins also catenate/ decatenate duplex rings. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). The conserved glutamate may act as a general base in strand joining and as a general acid in strand cleavage by topisomerases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173780 [Multi-domain] Cd Length: 115 Bit Score: 192.34 E-value: 6.38e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 438 CTLILTEGDSAKALAVSsvfalsafltfcclqmsGISVVgrnHYGVFPLRGKLLNVREATHKQIMDNAEITSIKQILGLQ 517
Cdd:cd01030 1 CELILVEGDSAGGSAKQ-----------------GRDRV---FQAVFPLRGKILNVEKASLKKILKNEEIQNIIKALGLG 60
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 1376976423 518 QGKGYENTKSLRYGHLMIMTDQDHDGSHIKGLIINFIHTFWPSLLKVpGFLVEFIT 573
Cdd:cd01030 61 IGKDDFDLDKLRYGKIIIMTDADVDGSHIRTLLLTFFYRFWPSLLEN-GFLYIAQT 115
|
|
| GyrB |
COG0187 |
DNA gyrase/topoisomerase IV, subunit B [Replication, recombination and repair]; |
24-617 |
3.15e-33 |
|
DNA gyrase/topoisomerase IV, subunit B [Replication, recombination and repair];
Pssm-ID: 439957 [Multi-domain] Cd Length: 635 Bit Score: 137.85 E-value: 3.15e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 24 LEHVLLRPDTYVGSiekhtqtlwvyeggqlvnravTYVPGLYKIFDEILvnaaDNkqrdpSMD--------AVKVTISvE 95
Cdd:COG0187 17 LEAVRKRPGMYIGS---------------------TDERGLHHLVWEIV----DN-----SIDealagycdRIEVTLH-A 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 96 QNTISVYNNGDGVPVEVHNEQGVYVPEMI---------FGhlltSSNYddnekKTTGGRNGYGAKLANIFSTEFVIETad 166
Cdd:COG0187 66 DGSVTVEDNGRGIPVDIHPKEGKSALEVVltvlhaggkFD----GGSY-----KVSGGLHGVGASVVNALSERLEVEV-- 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 167 gKR-GKKYKQVFSnnmsaKSEPaISSCK----SNENWTKVTFKPDLAKFHMTYLEEDVVA--LMSKRVLdIAGclgrtVK 239
Cdd:COG0187 135 -KRdGKIYRQRFE-----RGKP-VGPLEkigkTDRTGTTVRFKPDPEIFETTEFDYETLAerLRELAFL-NKG-----LT 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 240 VELN---GQKLPVKTF------SDYVgLYLAsaqKGKEE-TLPRIY---ERANDRWEVCVSLSDGQFQQV-SFVNSIATI 305
Cdd:COG0187 202 ITLTderEEEPKEETFhyeggiKDFV-EYLN---EDKEPlHPEVIYfegEKDGIEVEVALQWNDGYSENIhSFVNNINTP 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 306 RGGTHV----QHVSEQIVSHIQEIVNKKNKNANVKGFQIRNHLWVFVNSLIDNPAFDSQTKETLTTR------QTSFGSK 375
Cdd:COG0187 278 EGGTHEtgfrTALTRVINDYARKNGLLKEKDKNLTGDDVREGLTAVISVKLPEPQFEGQTKTKLGNSeargivESVVSEK 357
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 376 CElspEFL---KKVSKcGVVDNVLSWADF----KQSKELKKNDGAKRqRLTGIAKLDDANDaggKNSEACTLILTEGDSA 448
Cdd:COG0187 358 LE---HYLeenPAEAK-KILEKAILAARAreaaRKARELVRRKSALE-SSGLPGKLADCSS---KDPEESELFIVEGDSA 429
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 449 kalavssvfalsafltfcclqmsGISVV-GRN-HY-GVFPLRGKLLNVREATHKQIMDNAEITSIKQILGLQQGKGYENT 525
Cdd:COG0187 430 -----------------------GGSAKqGRDrEFqAILPLRGKILNVEKARLDKILKNEEIRDLITALGTGIGDDFDLE 486
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 526 KsLRYGHLMIMTDQDHDGSHIKGLIINFIHTFWPSLLKVpGFLveFI--TPIVKATHKNgKVLSFYTMPEYESWKESLRG 603
Cdd:COG0187 487 K-LRYHKIIIMTDADVDGAHIRTLLLTFFYRYMRPLIEA-GHV--YIaqPPLYRIKKGK-KTYYAYSDAELDELLKELKG 561
|
650
....*....|....
gi 1376976423 604 EtKGWSIKYYKGLG 617
Cdd:COG0187 562 K-KKVEIQRYKGLG 574
|
|
| gyrB |
PRK05644 |
DNA gyrase subunit B; Validated |
24-617 |
1.59e-25 |
|
DNA gyrase subunit B; Validated
Pssm-ID: 235542 [Multi-domain] Cd Length: 638 Bit Score: 113.65 E-value: 1.59e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 24 LEHVLLRPDTYVGSIEK----HTqtlwVYEggqLVNRAVtyvpglykifDEILVNAADNkqrdpsmdaVKVTISvEQNTI 99
Cdd:PRK05644 19 LEAVRKRPGMYIGSTGErglhHL----VYE---IVDNSI----------DEALAGYCDH---------IEVTIN-EDGSI 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 100 SVYNNGDGVPVEVHNEQGVYVPEMIFGHLLTSSNYDDNEKKTTGGRNGYGAKLANIFSTEFVIETadgKR-GKKYKQVFS 178
Cdd:PRK05644 72 TVTDNGRGIPVDIHPKTGKPAVEVVLTVLHAGGKFGGGGYKVSGGLHGVGVSVVNALSTWLEVEV---KRdGKIYYQEYE 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 179 NnmSAKSEPAISSCKSNENWTKVTFKPDLAKFHMTYLEEDVVAlmsKRVLDIAgCLGRTVKVELN---GQKLPVKTF--- 252
Cdd:PRK05644 149 R--GVPVTPLEVIGETDETGTTVTFKPDPEIFETTEFDYDTLA---TRLRELA-FLNKGLKITLTderEGEEKEETFhye 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 253 ---SDYVGlYLAsaqKGKEETLPR-IY-ERANDRWEVCVSL--SDGQFQQV-SFVNSIATIRGGTHVQ----HVSEQIVS 320
Cdd:PRK05644 223 ggiKEYVE-YLN---RNKEPLHEEpIYfEGEKDGIEVEVAMqyNDGYSENIlSFANNINTHEGGTHEEgfktALTRVIND 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 321 HIQEIVNKKNKNANVKGFQIRNHLWVFVNSLIDNPAFDSQTKETL------TTRQTSFGSKCElspEFLK---KVSKcGV 391
Cdd:PRK05644 299 YARKNKLLKEKDDNLTGEDVREGLTAVISVKHPEPQFEGQTKTKLgnsevrGIVDSVVSEALS---EFLEenpNVAK-KI 374
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 392 VDNVLSWA----DFKQSKELkkndgAKRQRLTGIA----KLDDANDaggKNSEACTLILTEGDSAKALAVSsvfalsafl 463
Cdd:PRK05644 375 VEKAILAArareAARKAREL-----TRRKSALESSslpgKLADCSS---KDPEESELYIVEGDSAGGSAKQ--------- 437
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 464 tfcclqmsgisvvGRN-HY-GVFPLRGKLLNVREATHKQIMDNAEITSIKQILGLQQGKGYeNTKSLRYGHLMIMTDQDH 541
Cdd:PRK05644 438 -------------GRDrRFqAILPLRGKILNVEKARLDKILKNEEIRALITALGTGIGDDF-DISKLRYHKIIIMTDADV 503
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1376976423 542 DGSHIKGLIINFIHTFWPSLLKvPGFLveFIT--PIVKATHknGKVLSFYTMPEYESWKESLRGET-KGWSIKYYKGLG 617
Cdd:PRK05644 504 DGAHIRTLLLTFFYRYMRPLIE-AGYV--YIAqpPLYKIKK--GGKEYAYSDEELDEILAELKLKGnPKYGIQRYKGLG 577
|
|
| DNA_gyraseB |
pfam00204 |
DNA gyrase B; This family represents the second domain of DNA gyrase B which has a ribosomal ... |
252-409 |
3.31e-21 |
|
DNA gyrase B; This family represents the second domain of DNA gyrase B which has a ribosomal S5 domain 2-like fold. This family is structurally related to PF01119.
Pssm-ID: 425522 [Multi-domain] Cd Length: 173 Bit Score: 92.29 E-value: 3.31e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 252 FSDYVGLYLASAQKGKEETLPRIYERANDRWEVCVSL---SDGQFQQVSFVNSIATIRGGTHVQHVSEQIV----SHIQE 324
Cdd:pfam00204 2 LKDFVEELNKDKKPLHKEIIYFEGESPDNRIEVEVALqwtDSYSENILSFVNNIATPEGGTHVDGFKSALTrtinEYAKK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 325 IVNKKNKNANVKGFQIRNHLWVFVNSLIDNPAFDSQTKETLTTRQTSFGSKCELSPEFLKKVSKC-GVVDNVLSWA-DFK 402
Cdd:pfam00204 82 KGLLKKKDEKITGEDIREGLTAVVSVKIPDPQFEGQTKEKLGNPEVKSAVEKIVSEKLEEFLEENpEIAKKILEKAlQAA 161
|
....*..
gi 1376976423 403 QSKELKK 409
Cdd:pfam00204 162 KARLAAR 168
|
|
| PRK09631 |
PRK09631 |
DNA topoisomerase IV subunit A; Provisional |
701-1148 |
2.29e-20 |
|
DNA topoisomerase IV subunit A; Provisional
Pssm-ID: 236598 [Multi-domain] Cd Length: 635 Bit Score: 97.47 E-value: 2.29e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 701 RSVPSMVDGLKPGQRKILFAAFKRNFTSQAKVAQFSGyvsEHSAYH-HGEQSLASTIIGMAqnfvgsNNINILAPIGQFG 779
Cdd:PRK09631 23 RAIPDVIDGLKPVQRRILHSLFEMHDGKFHKVANVVG---NTMKYHpHGDASIYEALVNLA------NKDLFIDKQGNFG 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 780 TRSQGgkDHASA-RYIYTSLTPLTRTIFPKPDdiLLNFLRE-DGQSIEPFWYAPILPMVLVNGSEGIGTGWSTFVPNYNP 857
Cdd:PRK09631 94 NLFTG--DPASAaRYIECRLTPLAKEVLYNKE--ITEYEPSyDGRNNEPLCLPAKIPVILIQGAEGIAVGMATKILPHNF 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 858 RDIVTNLKHLLRDEQLEPMDPWYKGfkGTIVKSATKESGVSYTVTGIVEQVNETTIRVLELPirkwtqdYKEFLEALLCG 937
Cdd:PRK09631 170 NEILQAVKSELLGESFALYPDFPTG--GIVDVSEYADGNGKVLVRAKIETKDEKTIVIREIP-------FGTTTESLIAS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 938 TE------KIKEPSIKDYrehnTDTRVHFEISLSEEKMAEALAEGLTKKFKLSTTIStSNMNLFdKDGHIRKYDTPEqIL 1011
Cdd:PRK09631 241 IEkaarkgKIKISSINDY----TAENVEIEIKLPRGVYASEVIEALYAYTDCEVSIS-VNLLVI-KDRYPVIYTVTD-II 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 1012 EdfYHIRLELYVKRKEvqvenLQYELLKLDNKvrfILGVVKGEIVVNNR--------KRAELLVELKTKGFTPFpkkaka 1083
Cdd:PRK09631 314 K--FHAEHLQKVLKME-----LELERAKLLEK---IFAKTLEQIFIEERiykrietiSSEEDVISIVLSELKPF------ 377
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1376976423 1084 sdlpvvggdgsdveaddEEKLNKGVRAGDYEYLLSMPIGTLTL-------EKVQQLCNERDKLEGDVEELKK 1148
Cdd:PRK09631 378 -----------------KEELSRDVTEEDIENLLKIPIRRISLfdidknqKEIRILNKELKSVEKNLKSIKG 432
|
|
| gyrA |
TIGR01063 |
DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). ... |
700-1052 |
6.12e-18 |
|
DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). Two apparently independently arising families, one in the Proteobacteria and one in Gram-positive lineages, are both designated toposisomerase IV. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273423 [Multi-domain] Cd Length: 800 Bit Score: 90.06 E-value: 6.12e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 700 ARSVPSMVDGLKPGQRKILFAAFKRNFTSQ---AKVAQFSGYVSehSAYH-HGEQSLASTIIGMAQNFvgSNNINILAPI 775
Cdd:TIGR01063 24 SRALPDVRDGLKPVHRRILYAMYELGLTPDkpyKKSARIVGDVM--GKYHpHGDSAIYDTLVRMAQDF--SLRYPLVDGQ 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 776 GQFGtrSQGGKDHASARYIYTSLTPLTRTIFPKPD----DILLNFlreDGQSIEPFWYAPILPMVLVNGSEGIGTGWSTF 851
Cdd:TIGR01063 100 GNFG--SIDGDPPAAMRYTEARLTKIAEELLRDIDketvDFVPNY---DGSEQEPTVLPSRFPNLLVNGSSGIAVGMATN 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 852 VPNYNPRDIVTNLKHLLRDEQLE----------PMDP-------------WYKGFKGTIVKSATKEsgvsytvtgiVEQV 908
Cdd:TIGR01063 175 IPPHNLGEIIDALLAYIDNPDISiqellevikgPDFPtggiilgrsgirsAYETGRGSIVIRARAE----------IEED 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 909 NE--TTIRVLELPirkWTQDYKEFLE--ALLCGTEKIKepSIKDYREHNTDTRVHFEISLSEEKMAEALAEGLTKKFKLS 984
Cdd:TIGR01063 245 SKgrEAIIVTEIP---YQVNKARLIEkiAELVREKKIE--GISDIRDESDREGIRIVIELKRDAVAEVVLNNLYKQTQLQ 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 985 TTISTSNMNLFDKdghirkydTPEQI-LEDFyhirLELYVK-RKEVQVENLQYELLKLDNKVRFILGVVK 1052
Cdd:TIGR01063 320 VSFGINMLALVKG--------LPKVLnLKEL----LEAFVEhRKDVITRRTIFELRKAEERAHILEGLLI 377
|
|
| TOPRIM_TopoIIA_GyrB |
cd03366 |
TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain ... |
438-562 |
9.83e-17 |
|
TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the duplex DNA to remove (relax) both positive and negative supercoils in DNA. These enzymes covalently attach to the 5' ends of the cut DNA, separate the free ends of the cleaved strands, pass another region of the duplex through this gap, then rejoin the ends. These proteins also catenate/ decatenate duplex rings. DNA gyrase is more effective at relaxing supercoils than decatentating DNA. DNA gyrase in addition inserts negative supercoils in the presence of ATP. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). The conserved glutamate may act as a general base in strand joining and as a general acid in strand cleavage by topisomerases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173786 [Multi-domain] Cd Length: 114 Bit Score: 77.31 E-value: 9.83e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 438 CTLILTEGDSAkalavssvfalsafltfcclqmSGISVVGRNHY--GVFPLRGKLLNVREATHKQIMDNAEITSIKQILG 515
Cdd:cd03366 1 SELYIVEGDSA----------------------GGSAKQGRDRRfqAILPLRGKILNVEKARLDKILKNEEIRALITALG 58
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 1376976423 516 LQQGKGYENTKsLRYGHLMIMTDQDHDGSHIKGLIINFIHTFWPSLL 562
Cdd:cd03366 59 TGIGEDFDLEK-LRYHKIIIMTDADVDGAHIRTLLLTFFFRYMRPLI 104
|
|
| gyrB |
PRK14939 |
DNA gyrase subunit B; Provisional |
86-553 |
1.59e-16 |
|
DNA gyrase subunit B; Provisional
Pssm-ID: 237860 [Multi-domain] Cd Length: 756 Bit Score: 85.15 E-value: 1.59e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 86 DAVKVTISVEqNTISVYNNGDGVPVEVHNEQGVYVPEMIFGHLLTSSNYDDNEKKTTGGRNGYGAKLANIFSTEFVIETa 165
Cdd:PRK14939 59 DDITVTIHAD-GSVSVSDNGRGIPTDIHPEEGVSAAEVIMTVLHAGGKFDQNSYKVSGGLHGVGVSVVNALSEWLELTI- 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 166 dgKR-GKKYKQVFSNNMsAKSEPAISScKSNENWTKVTFKPDLAKFHMTYLEEDVVAlmsKRVLDIAgCLGRTVKVELNG 244
Cdd:PRK14939 137 --RRdGKIHEQEFEHGV-PVAPLKVVG-ETDKTGTEVRFWPSPEIFENTEFDYDILA---KRLRELA-FLNSGVRIRLKD 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 245 QKLPVKTFSDYVG------LYLAsaqKGKEETLPRIYERANDRWEVCVSLS----DGQFQQV-SFVNSIATIRGGTHV-- 311
Cdd:PRK14939 209 ERDGKEEEFHYEGgikafvEYLN---RNKTPLHPNIFYFSGEKDGIGVEVAlqwnDSYQENVlCFTNNIPQRDGGTHLag 285
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 312 --QHVSEQIVSHIQEIVNKKNKNANVKGFQIRNHLwVFVNSL-IDNPAFDSQTKETLttrqtsfGSKcELSPeflkkvsk 388
Cdd:PRK14939 286 frAALTRTINNYIEKEGLAKKAKVSLTGDDAREGL-TAVLSVkVPDPKFSSQTKDKL-------VSS-EVRP-------- 348
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 389 cgVVDNVLS--WADF--KQSKELKK-----------NDGAKRQR-LT---GIakLDDAN------DAGGKNSEACTLILT 443
Cdd:PRK14939 349 --AVESLVNekLSEFleENPNEAKIivgkiidaaraREAARKAReLTrrkGA--LDIAGlpgklaDCQEKDPALSELYLV 424
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 444 EGDSAKAlavssvfalSAfltfccLQmsgisvvGRNHygVF----PLRGKLLNVREATHKQIMDNAEITSIKQILGLQQG 519
Cdd:PRK14939 425 EGDSAGG---------SA------KQ-------GRDR--KFqailPLKGKILNVEKARFDKMLSSQEIGTLITALGCGIG 480
|
490 500 510
....*....|....*....|....*....|....
gi 1376976423 520 KGYENTKSLRYGHLMIMTDQDHDGSHIKGLIINF 553
Cdd:PRK14939 481 RDEFNPDKLRYHKIIIMTDADVDGSHIRTLLLTF 514
|
|
| HATPase_GyrB-like |
cd16928 |
Histidine kinase-like ATPase domain of the B subunit of DNA gyrase; This family includes ... |
64-248 |
6.48e-16 |
|
Histidine kinase-like ATPase domain of the B subunit of DNA gyrase; This family includes histidine kinase-like ATPase domain of the B subunit of DNA gyrase. Bacterial DNA gyrase is a type II topoisomerase (type II as it transiently cleaves both strands of DNA) which catalyzes the introduction of negative supercoils into DNA, possibly by a mechanism in which one segment of the double-stranded DNA substrate is passed through a transient break in a second segment. It consists of GyrA and GyrB subunits in an A2B2 stoichiometry; GyrA subunits catalyze strand-breakage and reunion reactions, and GyrB subunits hydrolyze ATP. DNA gyrase is found in bacteria, plants and archaea, but as it is absent in humans it is a possible drug target for the treatment of bacterial and parasite infections.
Pssm-ID: 340405 [Multi-domain] Cd Length: 180 Bit Score: 77.19 E-value: 6.48e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 64 LYKIFDEILVNAADNkqrdpSM----DAVKVTISvEQNTISVYNNGDGVPVEVHNEQGVYVPEMIFGHLLTSSNYDDNEK 139
Cdd:cd16928 1 LHHLVWEIVDNSIDE-----ALagyaTEIEVTLH-EDNSITVEDNGRGIPVDIHPKTGKSAVEVVLTVLHAGGKFDGGSY 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 140 KTTGGRNGYGAKLANIFSTEFVIETadgKR-GKKYKQVFSNNMSAKSEPAISSCKsnENWTKVTFKPDLAKFHMTYLEED 218
Cdd:cd16928 75 KVSGGLHGVGVSVVNALSERLEVEV---KRdGKIYRQEFSRGGPLTPLEVIGETK--KTGTTVRFWPDPEIFEKTEFDFD 149
|
170 180 190
....*....|....*....|....*....|
gi 1376976423 219 VVAlmsKRVLDIAgCLGRTVKVELNGQKLP 248
Cdd:cd16928 150 TLK---RRLRELA-FLNKGLKIVLEDERTG 175
|
|
| PRK09630 |
PRK09630 |
DNA topoisomerase IV subunit A; Provisional |
699-977 |
8.32e-16 |
|
DNA topoisomerase IV subunit A; Provisional
Pssm-ID: 170022 Cd Length: 479 Bit Score: 81.86 E-value: 8.32e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 699 LARSVPSMVDGLKPGQRKILFAAFKRNFTSQAKVAQFSGYVsehSAYH-HGEQSLASTIIGMAqnfvgsNNINILAPIGQ 777
Cdd:PRK09630 21 LERAIPHILDGLKPVQRRLLWTLFRMDDGKMHKVANIAGRT---MALHpHGDAPIVEALVVLA------NKGYLIDTQGN 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 778 FGTrSQGGKDHASARYIYTSLTPLTRTIFPKPDdiLLNFLRE-DGQSIEPFWYAPILPMVLVNGSEGIGTGWSTFVPNYN 856
Cdd:PRK09630 92 FGN-PLTGDPHAAARYIEARLSPLAKEVLFNTD--LMTFHDSyDGREKEPDILPAKLPLLLLHGVDGIAVGMTTKIFPHN 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 857 PRDIVTNLKHLLRDEQLEPMDPWYKGfkGTIVKSATKESGVSYTVTGIVEQVNETTIRVLELPIRKWTQDYKEFLE-ALL 935
Cdd:PRK09630 169 FCELLEAQIAILNDQPFTLLPDFPSG--GTMDASEYQDGLGSITLRASIDIINDKTLLIKEICPSTTTETLIRSIEnAAK 246
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 1376976423 936 CGTEKIKepSIKDYrehNTDtRVHFEISLSEEKMAEALAEGL 977
Cdd:PRK09630 247 RGIIKID--SIQDF---STD-LPHIEIKLPKGIYAKDLLRPL 282
|
|
| TopoII_MutL_Trans |
cd00329 |
MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the ... |
252-366 |
4.30e-13 |
|
MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is known to be important in nucleotide hydrolysis and the transduction of structural signals from ATP-binding site to the DNA breakage/reunion regions of the enzymes. The GyrB dimerizes in response to ATP binding, and is homologous to the N-terminal half of eukaryotic Topo II and the ATPase fragment of MutL. Type II DNA topoisomerases catalyze the ATP-dependent transport of one DNA duplex through another, in the process generating transient double strand breaks via covalent attachments to both DNA strands at the 5' positions. Included in this group are proteins similar to human MLH1 and PMS2. MLH1 forms a heterodimer with PMS2 which functions in meiosis and in DNA mismatch repair (MMR). Cells lacking either hMLH1 or hPMS2 have a strong mutator phenotype and display microsatellite instability (MSI). Mutation in hMLH1 accounts for a large fraction of Lynch syndrome (HNPCC) families.
Pssm-ID: 238202 [Multi-domain] Cd Length: 107 Bit Score: 66.90 E-value: 4.30e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 252 FSDYVGLYLasaqkGKEETLPRIYERAND---RWEVCVSLSD----GQFQQVSFVNSIATIRGGTHVQHVSEQIVSHIqe 324
Cdd:cd00329 1 LKDRLAEIL-----GDKVADKLIYVEGESdgfRVEGAISYPDsgrsSKDRQFSFVNGRPVREGGTHVKAVREAYTRAL-- 73
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 1376976423 325 ivnkknknanvKGFQIRNHLWVFVNSLIDN--PAFD-SQTKETLT 366
Cdd:cd00329 74 -----------NGDDVRRYPVAVLSLKIPPslVDVNvHPTKEEVR 107
|
|
| PTZ00109 |
PTZ00109 |
DNA gyrase subunit b; Provisional |
24-561 |
1.51e-12 |
|
DNA gyrase subunit b; Provisional
Pssm-ID: 240272 [Multi-domain] Cd Length: 903 Bit Score: 72.61 E-value: 1.51e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 24 LEHVLLRPDTYVGSiekhtqtlwvyeggqlvnravTYVPGLYKIFDEILVNAADNKQrdpSMDAVKVTISVEQN-TISVY 102
Cdd:PTZ00109 111 LEAVRKRPGMYIGN---------------------TDEKGLHQLLFEILDNSVDEYL---AGECNKITVVLHKDgSVEIS 166
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 103 NNGDGVPVEVHNEQGVYVPEMIFGHLLTSSNYDD------------------NEKKT----------------------T 142
Cdd:PTZ00109 167 DNGRGIPCDVSEKTGKSGLETVLTVLHSGGKFQDtfpknsrsdksedkndtkSSKKGksshvkgpkeakekessqmyeyS 246
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 143 GGRNGYGAKLANIFSTEFVIETAdgKRGKKYKQVFSNNMSAKsEPAISSCKSNENWTKVTFKPDLAKF------HMTYLE 216
Cdd:PTZ00109 247 SGLHGVGLSVVNALSSFLKVDVF--KGGKIYSIELSKGKVTK-PLSVFSCPLKKRGTTIHFLPDYKHIfkthhqHTETEE 323
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 217 EDVVA------LMSKRVLDIAgCLGRTVKVELNGQKL-------PVKTFSDYVGL--YLASAQKGKEETLPRIY------ 275
Cdd:PTZ00109 324 EEGCKngfnldLIKNRIHELS-YLNPGLTFYLVDERIanennfyPYETIKHEGGTreFLEELIKDKTPLYKDINiisirg 402
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 276 ERANDRWEVCVSLSDGQF--QQVSFVNSIATIrGGTHVQHVSEQI---VSH-IQEIVNKKNKNANVKGFQIRNHLWVFVN 349
Cdd:PTZ00109 403 VIKNVNVEVSLSWSLESYtaLIKSFANNVSTT-AGTHIDGFKYAItrcVNGnIKKNGYFKGNFVNIPGEFIREGMTAIIS 481
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 350 SLIDNPAFDSQTKetlttrqTSFGSkcelspEFLKKVSKCGVVD----------NVLSWADFKQSKELKKNDGAK----- 414
Cdd:PTZ00109 482 VKLNGAEFDGQTK-------TKLGN------HLLKTILESIVFEqlseilefepNLLLAIYNKSLAAKKAFEEAKaakdl 548
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 415 -RQR-----LTGI-AKLDDANDAGGKNSEactLILTEGDSAkalavssvfalsafltfcclqmSGISVVGRNH--YGVFP 485
Cdd:PTZ00109 549 iRQKnnqyySTILpGKLVDCISDDIERNE---LFIVEGESA----------------------AGNAKQARNRefQAVLP 603
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 486 LRGKLLNVREAT-HKQIMDNAEITSIKQILGLQQGK----------GYENTKS---------------------LRYGHL 533
Cdd:PTZ00109 604 LKGKILNIEKIKnNKKVFENSEIKLLITSIGLSVNPvtwrqydlshGTKASKDesvqnnnstltkkknslfdtpLRYGKI 683
|
650 660
....*....|....*....|....*...
gi 1376976423 534 MIMTDQDHDGSHIKGLIINFIHTFWPSL 561
Cdd:PTZ00109 684 ILLTDADVDGEHLRILLLTLLYRFCPSL 711
|
|
| PRK12758 |
PRK12758 |
DNA gyrase/topoisomerase IV subunit A; |
699-850 |
4.27e-08 |
|
DNA gyrase/topoisomerase IV subunit A;
Pssm-ID: 237192 [Multi-domain] Cd Length: 869 Bit Score: 58.09 E-value: 4.27e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 699 LARSVPSMVDGLKPGQRKILFAAFKRNFTSQAKVAQFSGyvseHS-AYH-HGEQSLASTIIGMAQNFV----GSNNINIL 772
Cdd:PRK12758 40 LERAVPHIEDGLKPVQRRILHSMKEMDDGRYNKVANVVG----HTmQYHpHGDASIGDALVQLGQKDLlidtQGNWGNIL 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 773 ApigqfgtrsqgGKDHASARYIYTSLTPLT-RTIF-PKPDDILLNFlreDGQSIEPFWYAPILPMVLVNGSEGIGTGWST 850
Cdd:PRK12758 116 T-----------GDGAAAPRYIEARLSKFAlEVVFnPKTTEWQLSY---DGRKKEPVTLPVKFPLLLAQGAEGIAVGLST 181
|
|
| PRK13979 |
PRK13979 |
DNA topoisomerase IV subunit A; Provisional |
701-861 |
1.17e-07 |
|
DNA topoisomerase IV subunit A; Provisional
Pssm-ID: 237576 [Multi-domain] Cd Length: 957 Bit Score: 56.65 E-value: 1.17e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 701 RSVPSMVDGLKPGQRKILFAAFK-RNFTSQA--KVAQFSGYVSehSAYH-HGEQSLASTIIGMAQNFvgSNNINILAPIG 776
Cdd:PRK13979 37 RALPDVRDGLKPVHRRILYGAYMlKAFPDKPyyKSARIVGDIL--GKYHpHGDSSVYDAMVILAQDF--TTRMPLIDGHG 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 777 QFGtrSQGGKDHASARYIYTSLTPLT----RTIFPKPDDILLNFlreDGQSIEPFWYAPILPMVLVNGSEGIGTGWSTFV 852
Cdd:PRK13979 113 NWG--SIDGDSAAAMRYTEARLTPIAmemlRDIDKDVVNMVDNY---SDSEKEPEVLPARYPNLLVNGAFGIAVGLATNI 187
|
....*....
gi 1376976423 853 PNYNPRDIV 861
Cdd:PRK13979 188 PPHNLKEVI 196
|
|
| PRK05561 |
PRK05561 |
DNA topoisomerase 4 subunit A; |
701-869 |
1.41e-07 |
|
DNA topoisomerase 4 subunit A;
Pssm-ID: 235503 [Multi-domain] Cd Length: 742 Bit Score: 56.27 E-value: 1.41e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 701 RSVPSMVDGLKPGQRKILFAAFKRNFTSQAKvaqfsgYVSehSA---------YH-HGEQSLASTIIGMAQNFvgSNNIn 770
Cdd:PRK05561 34 RALPDVRDGLKPVQRRILYAMSELGLTPDAK------FKK--SArvvgdvlgkYHpHGDSSIYDAMVRMAQDF--SYRY- 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 771 ilaPI----GQFGtrSQGGKDHASARYIYTSLTPLTRTIFpkpDDI-------LLNFlreDGQSIEPFWYAPILPMVLVN 839
Cdd:PRK05561 103 ---PLvdgqGNFG--SIDGDPAAAMRYTEARLSPIAELLL---EEIdegtvdfVPNF---DGTLKEPTVLPARFPNLLLN 171
|
170 180 190
....*....|....*....|....*....|
gi 1376976423 840 GSEGIGTGWSTFVPNYNPRDIVTNLKHLLR 869
Cdd:PRK05561 172 GATGIAVGMATDIPPHNLREVIDAAIHLID 201
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
63-154 |
1.56e-06 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 48.13 E-value: 1.56e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 63 GLYKIFDEILVNAADNKqrdPSMDAVKVTISVE-QNTISVYNNGDGVPVEVHneqgvyvpEMIFGHLLTSSnyddnekKT 141
Cdd:pfam02518 5 RLRQVLSNLLDNALKHA---AKAGEITVTLSEGgELTLTVEDNGIGIPPEDL--------PRIFEPFSTAD-------KR 66
|
90
....*....|...
gi 1376976423 142 TGGRNGYGAKLAN 154
Cdd:pfam02518 67 GGGGTGLGLSIVR 79
|
|
| TopoII_Trans_DNA_gyrase |
cd00822 |
TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the ... |
259-369 |
3.72e-06 |
|
TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are heterodimers composed of two subunits. The type IIA enzymes are the predominant form of topoisomerase and are found in some bacteriophages, viruses and archaea, and in all bacteria and eukaryotes. All type IIA topoisomerases are related to each other at amino acid sequence level, though their oligomeric organization sometimes differs. TopoIIA enzymes cut both strands of the duplex DNA to remove (relax) both positive and negative supercoils in DNA. These enzymes covalently attach to the 5' ends of the cut DNA, separate the free ends of the cleaved strands, pass another region of the duplex through this gap, then rejoin the ends. TopoIIA enzymes also catenate/ decatenate duplex rings. E.coli DNA gyrase is a heterodimer composed of two subunits. E. coli DNA gyrase B subunit is known to be important in nucleotide hydrolysis and the transduction of structural signals from ATP-binding site to the DNA breakage/reunion regions of the enzymes.
Pssm-ID: 238419 [Multi-domain] Cd Length: 172 Bit Score: 48.71 E-value: 3.72e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 259 YLASAQKGKEETLPRIY----ERANDRWEVCVSLSDGQFQQV-SFVNSIATIRGGTHV----QHVSEQIVSHIQEIVNKK 329
Cdd:cd00822 6 FVEELNKDKEPLHEEPIyiegEKDGVEVEVALQWTDSYSENIlSFVNNIPTPEGGTHEtgfrAALTRAINDYAKKNNLLK 85
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 1376976423 330 NKNANVKGFQIRNHLwVFVNSL-IDNPAFDSQTKETLTTRQ 369
Cdd:cd00822 86 KKDVKLTGDDIREGL-TAVISVkVPEPQFEGQTKDKLGNSE 125
|
|
| PRK05560 |
PRK05560 |
DNA gyrase subunit A; Validated |
708-874 |
8.98e-06 |
|
DNA gyrase subunit A; Validated
Pssm-ID: 235502 [Multi-domain] Cd Length: 805 Bit Score: 50.41 E-value: 8.98e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 708 DGLKPGQRKILFAAFKRNFTSQakvaqfSGYVSehSA---------YH-HGEQSLASTIIGMAQNFvgsnniNILAPI-- 775
Cdd:PRK05560 36 DGLKPVHRRILYAMNELGNTPD------KPYKK--SArivgdvmgkYHpHGDSAVYDALVRMAQDF------SMRYPLvd 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 776 GQ--FGtrSQGGkDHASA-RYIYTSLTPLT---------RTIfpkpdDILLNFlreDGQSIEPfwyaPILPM----VLVN 839
Cdd:PRK05560 102 GQgnFG--SIDG-DPAAAmRYTEARMSKIAhelladidkETV-----DFVPNY---DGSEQEP----TVLPArfpnLLVN 166
|
170 180 190
....*....|....*....|....*....|....*
gi 1376976423 840 GSEGIGTGWSTFVPNYNPRDIVTNLKHLLRDEQLE 874
Cdd:PRK05560 167 GSSGIAVGMATNIPPHNLGEVIDACLALIDNPDIT 201
|
|
| GyrA |
COG0188 |
DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair]; |
708-874 |
9.86e-06 |
|
DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];
Pssm-ID: 439958 [Multi-domain] Cd Length: 804 Bit Score: 50.04 E-value: 9.86e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 708 DGLKPGQRKILFAAFKRNFTSQAKvaqfsgYVSehSA---------YH-HGEQSLASTIIGMAQNFvgSNN---INilap 774
Cdd:COG0188 41 DGLKPVHRRILYAMHELGLTPDKP------YKK--SArvvgdvmgkYHpHGDSAVYDALVRMAQDF--SMRyplVD---- 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 775 iGQ--FGtrSQGGkDHASA-RYIYTSLTPLTRTIFpkpDDI-------LLNFlreDGQSIEP------FwyapilPMVLV 838
Cdd:COG0188 107 -GQgnFG--SIDG-DPAAAmRYTEARLAKIAEELL---ADIdkdtvdfVPNY---DGSEQEPtvlparF------PNLLV 170
|
170 180 190
....*....|....*....|....*....|....*.
gi 1376976423 839 NGSEGIGTGWSTFVPNYNPRDIVTNLKHLLRDEQLE 874
Cdd:COG0188 171 NGSSGIAVGMATNIPPHNLGEVIDACIALIDNPDAT 206
|
|
| PRK05035 |
PRK05035 |
electron transport complex protein RnfC; Provisional |
1135-1368 |
1.74e-05 |
|
electron transport complex protein RnfC; Provisional
Pssm-ID: 235334 [Multi-domain] Cd Length: 695 Bit Score: 49.18 E-value: 1.74e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 1135 ERDKLEGdvEELKKCTPKDLWEKDLDNF---LEQLTAQELEEEKEDELELKQMAKEGAAIFKRAAAGRKPAAKAKTADKE 1211
Cdd:PRK05035 463 EREKAAR--EARHKKAAEARAAKDKDAVaaaLARVKAKKAAATQPIVIKAGARPDNSAVIAAREARKAQARARQAEKQAA 540
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 1212 NAVKPTKKATAATKASNASKKAAKPVELDSEEEYFNTSLQDRLAAYAKGKGPLTEDNSMEDAVKEVSPPTkpnAPKAAPV 1291
Cdd:PRK05035 541 AAADPKKAAVAAAIARAKAKKAAQQAANAEAEEEVDPKKAAVAAAIARAKAKKAAQQAASAEPEEQVAEV---DPKKAAV 617
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1376976423 1292 AKKRANTKASKASKATEDVAAhDSPDAKVRKVRASPFNKKSGSvIPQLAKLSIEAEADSDVEAAPQARPKRRAARPA 1368
Cdd:PRK05035 618 AAAIARAKAKKAEQQANAEPE-EPVDPRKAAVAAAIARAKARK-AAQQQANAEPEEAEDPKKAAVAAAIARAKAKKA 692
|
|
| PRK05035 |
PRK05035 |
electron transport complex protein RnfC; Provisional |
1184-1382 |
2.72e-04 |
|
electron transport complex protein RnfC; Provisional
Pssm-ID: 235334 [Multi-domain] Cd Length: 695 Bit Score: 45.32 E-value: 2.72e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 1184 MAKEGAAifkRAAAgRKPAAKAKTADKENAVKPTKKATAATKASNASKKAAKPVELDSEEEyfntSLQDRLAAYAKGKgp 1263
Cdd:PRK05035 462 LEREKAA---REAR-HKKAAEARAAKDKDAVAAALARVKAKKAAATQPIVIKAGARPDNSA----VIAAREARKAQAR-- 531
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 1264 ltednsmedAVKEVSPPTKPNAPKAAPVAKKRANTKASKA---SKATEDVAAHDSPDAKVRKVRASPFNKKSGSVIPQLA 1340
Cdd:PRK05035 532 ---------ARQAEKQAAAAADPKKAAVAAAIARAKAKKAaqqAANAEAEEEVDPKKAAVAAAIARAKAKKAAQQAASAE 602
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 1376976423 1341 KLSIEAEAD--SDVEAAPQARPKRRAARPAVHYIESDTEEDKAA 1382
Cdd:PRK05035 603 PEEQVAEVDpkKAAVAAAIARAKAKKAEQQANAEPEEPVDPRKA 646
|
|
| PRK07003 |
PRK07003 |
DNA polymerase III subunit gamma/tau; |
1188-1368 |
3.09e-04 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 45.23 E-value: 3.09e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 1188 GAAIFKRAAAGRKPAAKAKTADKENAVKPTkkataatkaSNASKKAAKPVELDSEEeyfntslqdrlAAYAKGKGPLTED 1267
Cdd:PRK07003 378 GAVPAPGARAAAAVGASAVPAVTAVTGAAG---------AALAPKAAAAAAATRAE-----------APPAAPAPPATAD 437
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 1268 NSMEDAVKEVSPPTKPNAPkAAPVAKKRANTKASKASKATEDVAAHDSPDAkVRKVRASPFNKKSGSVIPQLAKLSIEAE 1347
Cdd:PRK07003 438 RGDDAADGDAPVPAKANAR-ASADSRCDERDAQPPADSGSASAPASDAPPD-AAFEPAPRAAAPSAATPAAVPDARAPAA 515
|
170 180
....*....|....*....|.
gi 1376976423 1348 ADSDVEAAPQARPKRRAARPA 1368
Cdd:PRK07003 516 ASREDAPAAAAPPAPEARPPT 536
|
|
| Toprim |
pfam01751 |
Toprim domain; This is a conserved region from DNA primase. This corresponds to the Toprim ... |
439-553 |
4.50e-04 |
|
Toprim domain; This is a conserved region from DNA primase. This corresponds to the Toprim domain common to DnaG primases, topoisomerases, OLD family nucleases and RecR proteins. Both DnaG motifs IV and V are present in the alignment, the DxD (V) motif may be involved in Mg2+ binding and mutations to the conserved glutamate (IV) completely abolish DnaG type primase activity. DNA primase EC:2.7.7.6 is a nucleotidyltransferase it synthesizes the oligoribonucleotide primers required for DNA replication on the lagging strand of the replication fork; it can also prime the leading stand and has been implicated in cell division. This family also includes the atypical archaeal A subunit from type II DNA topoisomerases. Type II DNA topoisomerases catalyze the relaxation of DNA supercoiling by causing transient double strand breaks.
Pssm-ID: 396354 [Multi-domain] Cd Length: 93 Bit Score: 40.80 E-value: 4.50e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 439 TLILTEGDSaKALAVSSVFalsafltfcclqmsgisvvGRNHYGVFPLRGKLLNVREATHKQImdnaeITSIKQILglqq 518
Cdd:pfam01751 1 ELIIVEGPS-DAIALEKAL-------------------GGGFQAVVAVLGHLLSLEKGPKKKA-----LKALKELA---- 51
|
90 100 110
....*....|....*....|....*....|....*
gi 1376976423 519 gkgyentksLRYGHLMIMTDQDHDGSHIKGLIINF 553
Cdd:pfam01751 52 ---------LKAKEVILATDPDREGEAIALKLLEL 77
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
1193-1392 |
5.88e-04 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 44.75 E-value: 5.88e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 1193 KRAAAGRKPAAKAKTADKENAVKPTKKATAATKASNASKKAAKPVELDSEEEYFNTSLQDRLAAYAKGKgplTEDNSMED 1272
Cdd:PTZ00121 1230 KKAEEAKKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKA---EEKKKADE 1306
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376976423 1273 AVKEVSPPTKPN-APKAAPVAKKRANT---KASKASKATEdvAAHDSPDAKVRKVRASPFNKKSgsvipqlAKLSIEAEA 1348
Cdd:PTZ00121 1307 AKKKAEEAKKADeAKKKAEEAKKKADAakkKAEEAKKAAE--AAKAEAEAAADEAEAAEEKAEA-------AEKKKEEAK 1377
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 1376976423 1349 DSDVEAAPQARPKRRAARpavhyIESDTEEDKAASEDISDFEDE 1392
Cdd:PTZ00121 1378 KKADAAKKKAEEKKKADE-----AKKKAEEDKKKADELKKAAAA 1416
|
|
| |
