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Conserved domains on  [gi|1663450710|ref|XP_029139103|]
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uncharacterized protein LOC107283624 [Protobothrops mucrosquamatus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2534-2634 2.27e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 119.73  E-value: 2.27e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710 2534 VYRIKLLENTASGSLVIILNATDIDEGINREISYFFTYSlalHVTKMFSINSDTGEIRVIGKLDYEESKFYELPIVAEDK 2613
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSG---NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                           90       100
                   ....*....|....*....|.
gi 1663450710 2614 GNSPLSGHCKVLIDVLDINDN 2634
Cdd:cd11304     78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 191-291 2.00e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 117.03  E-value: 2.00e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710  191 VYRVKLLENSASGSLVITLNATDLDEGINREIFYSFHDSVPLHvtkLFSINSDTGEIRVIGKLDYEKSKFYELPIVAEDK 270
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDG---LFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                           90       100
                   ....*....|....*....|.
gi 1663450710  271 GNSPLLGHCKVLIEMLDMNDN 291
Cdd:cd11304     78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1006-1106 5.93e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 112.79  E-value: 5.93e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710 1006 VYRIKLLENIASESLVITLNATDLDEGINREILYFFsnkVPTHVSELFSINSDTGKIRVIGKLDYEESMFYELPIVAEDK 1085
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI---VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                           90       100
                   ....*....|....*....|.
gi 1663450710 1086 GNSPLFGHCKVLIEVLDMNDN 1106
Cdd:cd11304     78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3294-3393 1.29e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 108.94  E-value: 1.29e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710 3294 VYNVQILENSE-NEVIFKVNATDLDEGTNREITYissNFSPTNGKEKIILDHQTGEIYVKGHLDFEERNFYEIHVEAKDN 3372
Cdd:cd11304      1 SYEVSVPENAPpGTVVLTVSATDPDSGENGEVTY---SIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                           90       100
                   ....*....|....*....|.
gi 1663450710 3373 RNPPLSGHCKVLIEILDLNDN 3393
Cdd:cd11304     78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 405-504 4.39e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.40  E-value: 4.39e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710  405 SYTVFVKENNPPGAHIFTVSASDPDVAENALITYWIDEKlwPLSSYISVHSESGKLYALQSLDYEELKLLEFQVRAKDAG 484
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSG--NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                           90       100
                   ....*....|....*....|
gi 1663450710  485 MPSLCGNATVQVFVLDENDN 504
Cdd:cd11304     79 GPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2748-2847 7.71e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.01  E-value: 7.71e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710 2748 SYTVFVKENNPPGAHIFTVSASDPDVAENALITYWIDEKlwPLTSYISVHSESGKLYALQSLDYEELKLLEFQVRAKDAG 2827
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSG--NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                           90       100
                   ....*....|....*....|
gi 1663450710 2828 MPSLCGNATVQVFVLDENDN 2847
Cdd:cd11304     79 GPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1220-1319 1.22e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 106.24  E-value: 1.22e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710 1220 SYTVFVKENNPPGAHIFTVSASDPDVAENALITYWIDEKlwPLSSYISVHSESGKLYALQSLDYEELKLLEFQVRAKDAG 1299
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSG--NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                           90       100
                   ....*....|....*....|
gi 1663450710 1300 MPSLCGNATLQVFVLDENDN 1319
Cdd:cd11304     79 GPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3433-3532 1.29e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 106.24  E-value: 1.29e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710 3433 SYTVFVKENNPPGAYIFTVSASDPDVAENALITYWIGEKlwPLSSYISVHSESGKLYALQSLDYEELKLLEFQVRAKDAG 3512
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSG--NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                           90       100
                   ....*....|....*....|
gi 1663450710 3513 MPSLCGNATVQVFVLDENDN 3532
Cdd:cd11304     79 GPPLSSTATVTITVLDVNDN 98
Cadherin_2 super family cl29227
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 3085-3161 4.87e-25

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


The actual alignment was detected with superfamily member pfam08266:

Pssm-ID: 462413  Cd Length: 83  Bit Score: 101.06  E-value: 4.87e-25
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1663450710 3085 MEESQQGTFVGHIAQDLGLEVDELVSRMFQLVSKEQREYFQVNVQNGILFVNSQIDREKLYDKRAMCIVHLDALVEK 3161
Cdd:pfam08266    7 PEETERGSFVGNLAKDLGLEVGELAARGARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVLLEN 83
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1114-1212 1.00e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 100.85  E-value: 1.00e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710 1114 SLSVPLPEDSPPGTVVAILSATDRDSGTNGQINCFLFPPGV--PFKLEStfkNYYSLTVGAVLDREQVAEYRMVVTVEDQ 1191
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEdgLFSIDP---STGEITTAKPLDREEQSSYTLTVTATDG 77

                           90       100
                   ....*....|....*....|.
gi 1663450710 1192 GVPPLSSSISLLVPISDINDN 1212
Cdd:cd11304     78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 299-397 6.18e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 98.54  E-value: 6.18e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710  299 SLSVPLPEDSPPGTVVAILSASDRDSGTNGQINCFLFPPGV--PFKLEStfkNYYSLIVGAVLDREQVAEYRMVVTVEDQ 376
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEdgLFSIDP---STGEITTAKPLDREEQSSYTLTVTATDG 77

                           90       100
                   ....*....|....*....|.
gi 1663450710  377 GIPPLSSSISLLVPISDINDN 397
Cdd:cd11304     78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 90-183 1.45e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 97.38  E-value: 1.45e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710   90 DIASGTRLLLEGASDADIGTNALLNYKLS---PNKYFALDtgndeddSKSVVLVLKVPLDREESPVHHLILTATDGGEPK 166
Cdd:cd11304      9 NAPPGTVVLTVSATDPDSGENGEVTYSIVsgnEDGLFSID-------PSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|....*..
gi 1663450710  167 LTGTVQLVINVLDVNDN 183
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2445-2528 2.73e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


:

Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 96.26  E-value: 2.73e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710  2445 ASDADIGTNALLNYKLSPNNHFVLDSGNDEDGsksvVLVLKVPLDREESPVHHLVLTATDGGEPKLTGTVQLIINVLDVN 2524
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPETG----EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 1663450710  2525 DNPP 2528
Cdd:smart00112   78 DNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 917-1000 2.13e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


:

Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 87.79  E-value: 2.13e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710   917 ASDADIGTNALLTHRLSPN---KYFALDtgndedgSKSIVLVLKVPLDREESSVHHLVLTATDGGEPKLTGTVQLGINVL 993
Cdd:smart00112    2 ATDADSGENGKVTYSILSGnddGLFSID-------PETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74


                    ....*..
gi 1663450710   994 DINDNPP 1000
Cdd:smart00112   75 DVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3188-3286 1.12e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 77.74  E-value: 1.12e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710 3188 QFTIAESSLHNSRFPLEGTSDADIAANSLLSYRL---NPNLLFSLVIETYEhsvflfLDLNKPLDREECAVHRLCLLATD 3264
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvsgNEDGLFSIDPSTGE------ITTAKPLDREEQSSYTLTVTATD 76

                           90       100
                   ....*....|....*....|..
gi 1663450710 3265 VGDPQLTGTVQLGIKVLDANDN 3286
Cdd:cd11304     77 GGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2153-2234 2.03e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 76.97  E-value: 2.03e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710 2153 PGHIVGKIHALDADSGYNAWLRYELVEESSVPW-SVGQYSGEVSTKYPLDeSEGGKIQSIVVLVTDHGKPQLSATATLSV 2231
Cdd:cd11304     12 PGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLfSIDPSTGEITTAKPLD-REEQSSYTLTVTATDGGGPPLSSTATVTI 90


                   ...
gi 1663450710 2232 SLV 2234
Cdd:cd11304     91 TVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 525-617 1.17e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.04  E-value: 1.17e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710  525 PGHIVGKIHALDADSGYNAWLRYELLEESSGPW-SVGQYNGEVSTKYPLDeSEGGKIQSVLILVRDHGKPQLSATATLSV 603
Cdd:cd11304     12 PGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLfSIDPSTGEITTAKPLD-REEQSSYTLTVTATDGGGPPLSSTATVTI 90

                           90
                   ....*....|....
gi 1663450710  604 SLvtsgqtikTDIN 617
Cdd:cd11304     91 TV--------LDVN 96
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1847-1939 1.23e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.04  E-value: 1.23e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710 1847 PGHIVGKIHALDADSGYNAWLRYELVEESSVPW-SVGQYNGEVSTKYPLDeSEGGKIQSVLVLVKDHGKPQLSATATLSV 1925
Cdd:cd11304     12 PGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLfSIDPSTGEITTAKPLD-REEQSSYTLTVTATDGGGPPLSSTATVTI 90

                           90
                   ....*....|....
gi 1663450710 1926 SLvtsgqtikTDIN 1939
Cdd:cd11304     91 TV--------LDVN 96
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2868-2949 1.24e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.04  E-value: 1.24e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710 2868 PGHIVGKIHALDADSGYNAWLRYELVEESSVPW-SVGQYSGEVSTKYPLDeSEGGKIQSVLVLVKDHGKPQLSATATLSV 2946
Cdd:cd11304     12 PGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLfSIDPSTGEITTAKPLD-REEQSSYTLTVTATDGGGPPLSSTATVTI 90


                   ...
gi 1663450710 2947 SLV 2949
Cdd:cd11304     91 TVL 93
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2076-2134 1.92e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


:

Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 70.84  E-value: 1.92e-14
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 1663450710  2076 SSYISVHSESGKLYALQSLDYEELKLLEFQVRAKDAGMPSLCGNATVQVFVLDENDNAP 2134
Cdd:smart00112   23 DGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2642-2740 2.22e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 71.19  E-value: 2.22e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710 2642 SLSVPLPEDSPPGTVVAILSASDRDSGTNGQINCFLFPPGV--PFKLEStfkNYYSLIVGAVLDREQVAEYRMVVTVE** 2719
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEdgLFSIDP---STGEITTAKPLDREEQSSYTLTVTATDG 77

                           90       100
                   ....*....|....*....|.
gi 1663450710 2720 **PPLSSSISLLVPISDINDN 2740
Cdd:cd11304     78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1340-1432 1.09e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 69.26  E-value: 1.09e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710 1340 PGHIVGKIHALDADSGYNAWLRYELVEESSVPW-SVGQYSGEVSTKYPL--EESeggKIQSVLVFVKDHGKPQLSATATL 1416
Cdd:cd11304     12 PGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLfSIDPSTGEITTAKPLdrEEQ---SSYTLTVTATDGGGPPLSSTATV 88

                           90
                   ....*....|....*.
gi 1663450710 1417 SVSLvtsgqtikTDIN 1432
Cdd:cd11304     89 TITV--------LDVN 96
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1774-1828 5.72e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


:

Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 66.60  E-value: 5.72e-13
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 1663450710  1774 SVQSESGKLYALQSLDYEELKLLEFQVRAKDAGMPSLCGNATVQVFVLDENDNTP 1828
Cdd:smart00112   27 SIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_2 super family cl29227
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 2365-2401 5.02e-12

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


The actual alignment was detected with superfamily member pfam08266:

Pssm-ID: 462413  Cd Length: 83  Bit Score: 64.09  E-value: 5.02e-12
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1663450710 2365 EVNLQNGILFVNSRIDREELCAKTADCVLHLEVIVEK 2401
Cdd:pfam08266   47 QLNPETGDLLLNEKLDREELCGSTEPCVLHFQVLLEN 83
Cadherin_2 super family cl29227
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 8-40 7.06e-10

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


The actual alignment was detected with superfamily member pfam08266:

Pssm-ID: 462413  Cd Length: 83  Bit Score: 57.92  E-value: 7.06e-10
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1663450710    8 NNGILFVNSRIDREELCAKTADCVLHLEVIVEK 40
Cdd:pfam08266   51 ETGDLLLNEKLDREELCGSTEPCVLHFQVLLEN 83
Cadherin_2 super family cl29227
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 840-871 1.28e-09

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


The actual alignment was detected with superfamily member pfam08266:

Pssm-ID: 462413  Cd Length: 83  Bit Score: 57.15  E-value: 1.28e-09
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1663450710  840 NGILFVNSRIDREELCAKTADCVLHLEVIVEK 871
Cdd:pfam08266   52 TGDLLLNEKLDREELCGSTEPCVLHFQVLLEN 83
Cadherin_C_2 pfam16492
Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some ...
 2974-3004 2.06e-05

Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some proto-cadherins. It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. Cadherins are cell-surface receptors that function in cell adhesion, cell polarity, and tissue morphogenesis.


:

Pssm-ID: 465139  Cd Length: 84  Bit Score: 45.21  E-value: 2.06e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1663450710 2974 SINVYLIIAICSVSSLFLLAILIYVALRCHC 3004
Cdd:pfam16492    1 DLTFYLVIALASVSFLFLLFVIVLIALRLRR 31
Cadherin_C_2 pfam16492
Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some ...
 631-709 6.98e-05

Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some proto-cadherins. It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. Cadherins are cell-surface receptors that function in cell adhesion, cell polarity, and tissue morphogenesis.


:

Pssm-ID: 465139  Cd Length: 84  Bit Score: 44.05  E-value: 6.98e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710  631 SINIYLIIAICSVSSLFLLATLIYVALRCHCKAK------ESMVYGPGMATLVCASEVGSWSYSNRHSHILAGVSteagA 704
Cdd:pfam16492    1 DLTFYLVIALASVSFLFLLFVIVLIALRLRRWRSsallqsSGNLCSVPAPHFPGNDGTGTLPQSYSYEVCLTSDS----G 76


                   ....*
gi 1663450710  705 KSDLM 709
Cdd:pfam16492   77 KSEFK 81
Cadherin_C_2 pfam16492
Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some ...
 2259-2287 9.55e-05

Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some proto-cadherins. It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. Cadherins are cell-surface receptors that function in cell adhesion, cell polarity, and tissue morphogenesis.


:

Pssm-ID: 465139  Cd Length: 84  Bit Score: 43.67  E-value: 9.55e-05
                           10        20
                   ....*....|....*....|....*....
gi 1663450710 2259 SINIYLIIAICSVSSLFLLAVFVYMALRC 2287
Cdd:pfam16492    1 DLTFYLVIALASVSFLFLLFVIVLIALRL 29
Cadherin_C_2 pfam16492
Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some ...
 1446-1524 1.43e-04

Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some proto-cadherins. It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. Cadherins are cell-surface receptors that function in cell adhesion, cell polarity, and tissue morphogenesis.


:

Pssm-ID: 465139  Cd Length: 84  Bit Score: 42.90  E-value: 1.43e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710 1446 SINVYLIIAICSVSSLFLLATLIYMALRCHCKAK------ESMVYGPGMATLVCASEVGSWSYSNRHSHILAGVSteagA 1519
Cdd:pfam16492    1 DLTFYLVIALASVSFLFLLFVIVLIALRLRRWRSsallqsSGNLCSVPAPHFPGNDGTGTLPQSYSYEVCLTSDS----G 76


                   ....*
gi 1663450710 1520 KSDLM 1524
Cdd:pfam16492   77 KSEFK 81
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2534-2634 2.27e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 119.73  E-value: 2.27e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710 2534 VYRIKLLENTASGSLVIILNATDIDEGINREISYFFTYSlalHVTKMFSINSDTGEIRVIGKLDYEESKFYELPIVAEDK 2613
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSG---NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                           90       100
                   ....*....|....*....|.
gi 1663450710 2614 GNSPLSGHCKVLIDVLDINDN 2634
Cdd:cd11304     78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 191-291 2.00e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 117.03  E-value: 2.00e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710  191 VYRVKLLENSASGSLVITLNATDLDEGINREIFYSFHDSVPLHvtkLFSINSDTGEIRVIGKLDYEKSKFYELPIVAEDK 270
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDG---LFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                           90       100
                   ....*....|....*....|.
gi 1663450710  271 GNSPLLGHCKVLIEMLDMNDN 291
Cdd:cd11304     78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1006-1106 5.93e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 112.79  E-value: 5.93e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710 1006 VYRIKLLENIASESLVITLNATDLDEGINREILYFFsnkVPTHVSELFSINSDTGKIRVIGKLDYEESMFYELPIVAEDK 1085
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI---VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                           90       100
                   ....*....|....*....|.
gi 1663450710 1086 GNSPLFGHCKVLIEVLDMNDN 1106
Cdd:cd11304     78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3294-3393 1.29e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 108.94  E-value: 1.29e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710 3294 VYNVQILENSE-NEVIFKVNATDLDEGTNREITYissNFSPTNGKEKIILDHQTGEIYVKGHLDFEERNFYEIHVEAKDN 3372
Cdd:cd11304      1 SYEVSVPENAPpGTVVLTVSATDPDSGENGEVTY---SIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                           90       100
                   ....*....|....*....|.
gi 1663450710 3373 RNPPLSGHCKVLIEILDLNDN 3393
Cdd:cd11304     78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 405-504 4.39e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.40  E-value: 4.39e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710  405 SYTVFVKENNPPGAHIFTVSASDPDVAENALITYWIDEKlwPLSSYISVHSESGKLYALQSLDYEELKLLEFQVRAKDAG 484
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSG--NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                           90       100
                   ....*....|....*....|
gi 1663450710  485 MPSLCGNATVQVFVLDENDN 504
Cdd:cd11304     79 GPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2748-2847 7.71e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.01  E-value: 7.71e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710 2748 SYTVFVKENNPPGAHIFTVSASDPDVAENALITYWIDEKlwPLTSYISVHSESGKLYALQSLDYEELKLLEFQVRAKDAG 2827
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSG--NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                           90       100
                   ....*....|....*....|
gi 1663450710 2828 MPSLCGNATVQVFVLDENDN 2847
Cdd:cd11304     79 GPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1220-1319 1.22e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 106.24  E-value: 1.22e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710 1220 SYTVFVKENNPPGAHIFTVSASDPDVAENALITYWIDEKlwPLSSYISVHSESGKLYALQSLDYEELKLLEFQVRAKDAG 1299
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSG--NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                           90       100
                   ....*....|....*....|
gi 1663450710 1300 MPSLCGNATLQVFVLDENDN 1319
Cdd:cd11304     79 GPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3433-3532 1.29e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 106.24  E-value: 1.29e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710 3433 SYTVFVKENNPPGAYIFTVSASDPDVAENALITYWIGEKlwPLSSYISVHSESGKLYALQSLDYEELKLLEFQVRAKDAG 3512
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSG--NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                           90       100
                   ....*....|....*....|
gi 1663450710 3513 MPSLCGNATVQVFVLDENDN 3532
Cdd:cd11304     79 GPPLSSTATVTITVLDVNDN 98
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 3085-3161 4.87e-25

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 101.06  E-value: 4.87e-25
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1663450710 3085 MEESQQGTFVGHIAQDLGLEVDELVSRMFQLVSKEQREYFQVNVQNGILFVNSQIDREKLYDKRAMCIVHLDALVEK 3161
Cdd:pfam08266    7 PEETERGSFVGNLAKDLGLEVGELAARGARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVLLEN 83
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1114-1212 1.00e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 100.85  E-value: 1.00e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710 1114 SLSVPLPEDSPPGTVVAILSATDRDSGTNGQINCFLFPPGV--PFKLEStfkNYYSLTVGAVLDREQVAEYRMVVTVEDQ 1191
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEdgLFSIDP---STGEITTAKPLDREEQSSYTLTVTATDG 77

                           90       100
                   ....*....|....*....|.
gi 1663450710 1192 GVPPLSSSISLLVPISDINDN 1212
Cdd:cd11304     78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 299-397 6.18e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 98.54  E-value: 6.18e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710  299 SLSVPLPEDSPPGTVVAILSASDRDSGTNGQINCFLFPPGV--PFKLEStfkNYYSLIVGAVLDREQVAEYRMVVTVEDQ 376
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEdgLFSIDP---STGEITTAKPLDREEQSSYTLTVTATDG 77

                           90       100
                   ....*....|....*....|.
gi 1663450710  377 GIPPLSSSISLLVPISDINDN 397
Cdd:cd11304     78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 90-183 1.45e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 97.38  E-value: 1.45e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710   90 DIASGTRLLLEGASDADIGTNALLNYKLS---PNKYFALDtgndeddSKSVVLVLKVPLDREESPVHHLILTATDGGEPK 166
Cdd:cd11304      9 NAPPGTVVLTVSATDPDSGENGEVTYSIVsgnEDGLFSID-------PSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|....*..
gi 1663450710  167 LTGTVQLVINVLDVNDN 183
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2445-2528 2.73e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 96.26  E-value: 2.73e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710  2445 ASDADIGTNALLNYKLSPNNHFVLDSGNDEDGsksvVLVLKVPLDREESPVHHLVLTATDGGEPKLTGTVQLIINVLDVN 2524
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPETG----EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 1663450710  2525 DNPP 2528
Cdd:smart00112   78 DNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2553-2636 2.73e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 96.26  E-value: 2.73e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710  2553 NATDIDEGINREISYFFTYSlalHVTKMFSINSDTGEIRVIGKLDYEESKFYELPIVAEDKGNSPLSGHCKVLIDVLDIN 2632
Cdd:smart00112    1 SATDADSGENGKVTYSILSG---NDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 1663450710  2633 DNIP 2636
Cdd:smart00112   78 DNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2426-2526 1.33e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 94.69  E-value: 1.33e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710 2426 EQILSISE-LITGTQFSLEGASDADIGTNALLNYKLSPNN---HFVLDSgndedgsKSVVLVLKVPLDREESPVHHLVLT 2501
Cdd:cd11304      1 SYEVSVPEnAPPGTVVLTVSATDPDSGENGEVTYSIVSGNedgLFSIDP-------STGEITTAKPLDREEQSSYTLTVT 73

                           90       100
                   ....*....|....*....|....*
gi 1663450710 2502 ATDGGEPKLTGTVQLIINVLDVNDN 2526
Cdd:cd11304     74 ATDGGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 210-293 2.94e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 93.18  E-value: 2.94e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710   210 NATDLDEGINREIFYSFHDSVPLHvtkLFSINSDTGEIRVIGKLDYEKSKFYELPIVAEDKGNSPLLGHCKVLIEMLDMN 289
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDG---LFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 1663450710   290 DNIP 293
Cdd:smart00112   78 DNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 102-185 3.71e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 92.80  E-value: 3.71e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710   102 ASDADIGTNALLNYKLSPN---KYFALDtgndeddSKSVVLVLKVPLDREESPVHHLILTATDGGEPKLTGTVQLVINVL 178
Cdd:smart00112    2 ATDADSGENGKVTYSILSGnddGLFSID-------PETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74


                    ....*..
gi 1663450710   179 DVNDNPP 185
Cdd:smart00112   75 DVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1025-1108 2.73e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 90.49  E-value: 2.73e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710  1025 NATDLDEGINREILYFFsnkVPTHVSELFSINSDTGKIRVIGKLDYEESMFYELPIVAEDKGNSPLFGHCKVLIEVLDMN 1104
Cdd:smart00112    1 SATDADSGENGKVTYSI---LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 1663450710  1105 DNIP 1108
Cdd:smart00112   78 DNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3312-3395 7.88e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 88.95  E-value: 7.88e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710  3312 NATDLDEGTNREITYissNFSPTNGKEKIILDHQTGEIYVKGHLDFEERNFYEIHVEAKDNRNPPLSGHCKVLIEILDLN 3391
Cdd:smart00112    1 SATDADSGENGKVTY---SILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 1663450710  3392 DNPP 3395
Cdd:smart00112   78 DNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 917-1000 2.13e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 87.79  E-value: 2.13e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710   917 ASDADIGTNALLTHRLSPN---KYFALDtgndedgSKSIVLVLKVPLDREESSVHHLVLTATDGGEPKLTGTVQLGINVL 993
Cdd:smart00112    2 ATDADSGENGKVTYSILSGnddGLFSID-------PETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74


                    ....*..
gi 1663450710   994 DINDNPP 1000
Cdd:smart00112   75 DVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 906-998 2.59e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.14  E-value: 2.59e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710  906 TASGTRFPLEAASDADIGTNALLTHRLS---PNKYFALD--TGndedgsksiVLVLKVPLDREESSVHHLVLTATDGGEP 980
Cdd:cd11304     10 APPGTVVLTVSATDPDSGENGEVTYSIVsgnEDGLFSIDpsTG---------EITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 1663450710  981 KLTGTVQLGINVLDINDN 998
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2767-2849 7.18e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 86.25  E-value: 7.18e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710  2767 SASDPDVAENALITYWIDEKlwPLTSYISVHSESGKLYALQSLDYEELKLLEFQVRAKDAGMPSLCGNATVQVFVLDEND 2846
Cdd:smart00112    1 SATDADSGENGKVTYSILSG--NDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVND 78


                    ...
gi 1663450710  2847 NAP 2849
Cdd:smart00112   79 NAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1239-1321 1.43e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 85.48  E-value: 1.43e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710  1239 SASDPDVAENALITYWIDEKlwPLSSYISVHSESGKLYALQSLDYEELKLLEFQVRAKDAGMPSLCGNATLQVFVLDEND 1318
Cdd:smart00112    1 SATDADSGENGKVTYSILSG--NDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVND 78


                    ...
gi 1663450710  1319 NAP 1321
Cdd:smart00112   79 NAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3452-3534 1.45e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 85.48  E-value: 1.45e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710  3452 SASDPDVAENALITYWIGEKlwPLSSYISVHSESGKLYALQSLDYEELKLLEFQVRAKDAGMPSLCGNATVQVFVLDEND 3531
Cdd:smart00112    1 SATDADSGENGKVTYSILSG--NDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVND 78


                    ...
gi 1663450710  3532 NAP 3534
Cdd:smart00112   79 NAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 424-506 2.97e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 84.71  E-value: 2.97e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710   424 SASDPDVAENALITYWIDEKlwPLSSYISVHSESGKLYALQSLDYEELKLLEFQVRAKDAGMPSLCGNATVQVFVLDEND 503
Cdd:smart00112    1 SATDADSGENGKVTYSILSG--NDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVND 78


                    ...
gi 1663450710   504 NTP 506
Cdd:smart00112   79 NAP 81
Cadherin pfam00028
Cadherin domain;
2535-2629 1.01e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 83.50  E-value: 1.01e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710 2535 YRIKLLENTASGSLVIILNATDIDEGINREISYFFTYSlalHVTKMFSINSDTGEIRVIGKLDYEESKFYELPIVAEDKG 2614
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGG---GPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                           90
                   ....*....|....*
gi 1663450710 2615 NSPLSGHCKVLIDVL 2629
Cdd:pfam00028   78 GPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1133-1214 5.77e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 78.16  E-value: 5.77e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710  1133 SATDRDSGTNGQINCFLFPPGV--PFKLEStfkNYYSLTVGAVLDREQVAEYRMVVTVEDQGVPPLSSSISLLVPISDIN 1210
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDdgLFSIDP---ETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 1663450710  1211 DNAP 1214
Cdd:smart00112   78 DNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3188-3286 1.12e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 77.74  E-value: 1.12e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710 3188 QFTIAESSLHNSRFPLEGTSDADIAANSLLSYRL---NPNLLFSLVIETYEhsvflfLDLNKPLDREECAVHRLCLLATD 3264
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvsgNEDGLFSIDPSTGE------ITTAKPLDREEQSSYTLTVTATD 76

                           90       100
                   ....*....|....*....|..
gi 1663450710 3265 VGDPQLTGTVQLGIKVLDANDN 3286
Cdd:cd11304     77 GGGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
192-284 1.41e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 77.34  E-value: 1.41e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710  192 YRVKLLENSASGSLVITLNATDLDEGINREIFYSFhdsVPLHVTKLFSINSDTGEIRVIGKLDYEKSKFYELPIVAEDKG 271
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSI---LGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                           90
                   ....*....|...
gi 1663450710  272 NSPLLGHCKVLIE 284
Cdd:pfam00028   78 GPPLSSTATVTIT 90
Cadherin pfam00028
Cadherin domain;
1007-1101 1.67e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 77.34  E-value: 1.67e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710 1007 YRIKLLENIASESLVITLNATDLDEGINREILYFFSNkvpTHVSELFSINSDTGKIRVIGKLDYEESMFYELPIVAEDKG 1086
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILG---GGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                           90
                   ....*....|....*
gi 1663450710 1087 NSPLFGHCKVLIEVL 1101
Cdd:pfam00028   78 GPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2153-2234 2.03e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 76.97  E-value: 2.03e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710 2153 PGHIVGKIHALDADSGYNAWLRYELVEESSVPW-SVGQYSGEVSTKYPLDeSEGGKIQSIVVLVTDHGKPQLSATATLSV 2231
Cdd:cd11304     12 PGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLfSIDPSTGEITTAKPLD-REEQSSYTLTVTATDGGGPPLSSTATVTI 90


                   ...
gi 1663450710 2232 SLV 2234
Cdd:cd11304     91 TVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 525-617 1.17e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.04  E-value: 1.17e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710  525 PGHIVGKIHALDADSGYNAWLRYELLEESSGPW-SVGQYNGEVSTKYPLDeSEGGKIQSVLILVRDHGKPQLSATATLSV 603
Cdd:cd11304     12 PGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLfSIDPSTGEITTAKPLD-REEQSSYTLTVTATDGGGPPLSSTATVTI 90

                           90
                   ....*....|....
gi 1663450710  604 SLvtsgqtikTDIN 617
Cdd:cd11304     91 TV--------LDVN 96
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1847-1939 1.23e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.04  E-value: 1.23e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710 1847 PGHIVGKIHALDADSGYNAWLRYELVEESSVPW-SVGQYNGEVSTKYPLDeSEGGKIQSVLVLVKDHGKPQLSATATLSV 1925
Cdd:cd11304     12 PGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLfSIDPSTGEITTAKPLD-REEQSSYTLTVTATDGGGPPLSSTATVTI 90

                           90
                   ....*....|....
gi 1663450710 1926 SLvtsgqtikTDIN 1939
Cdd:cd11304     91 TV--------LDVN 96
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2868-2949 1.24e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.04  E-value: 1.24e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710 2868 PGHIVGKIHALDADSGYNAWLRYELVEESSVPW-SVGQYSGEVSTKYPLDeSEGGKIQSVLVLVKDHGKPQLSATATLSV 2946
Cdd:cd11304     12 PGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLfSIDPSTGEITTAKPLD-REEQSSYTLTVTATDGGGPPLSSTATVTI 90


                   ...
gi 1663450710 2947 SLV 2949
Cdd:cd11304     91 TVL 93
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 318-399 2.43e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 73.54  E-value: 2.43e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710   318 SASDRDSGTNGQINCFLFPPGV--PFKLEStfkNYYSLIVGAVLDREQVAEYRMVVTVEDQGIPPLSSSISLLVPISDIN 395
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDdgLFSIDP---ETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 1663450710   396 DNVP 399
Cdd:smart00112   78 DNAP 81
Cadherin pfam00028
Cadherin domain;
3295-3388 5.21e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 73.10  E-value: 5.21e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710 3295 YNVQILENS-ENEVIFKVNATDLDEGTNREITYissNFSPTNGKEKIILDHQTGEIYVKGHLDFEERNFYEIHVEAKDNR 3373
Cdd:pfam00028    1 YSASVPENApVGTEVLTVTATDPDLGPNGRIFY---SILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                           90
                   ....*....|....*
gi 1663450710 3374 NPPLSGHCKVLIEIL 3388
Cdd:pfam00028   78 GPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3207-3288 7.32e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 72.00  E-value: 7.32e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710  3207 SDADIAANSLLSYRL---NPNLLFSLVIETYEHSVflfldlNKPLDREECAVHRLCLLATDVGDPQLTGTVQLGIKVLDA 3283
Cdd:smart00112    3 TDADSGENGKVTYSIlsgNDDGLFSIDPETGEITT------TKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDV 76


                    ....*
gi 1663450710  3284 NDNLP 3288
Cdd:smart00112   77 NDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2076-2134 1.92e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 70.84  E-value: 1.92e-14
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 1663450710  2076 SSYISVHSESGKLYALQSLDYEELKLLEFQVRAKDAGMPSLCGNATVQVFVLDENDNAP 2134
Cdd:smart00112   23 DGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
406-499 2.12e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.18  E-value: 2.12e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710  406 YTVFVKENNPPGAHIFTVSASDPDVAENALITYWIDEKlwPLSSYISVHSESGKLYALQSLDYEELKLLEFQVRAKDAGM 485
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGG--GPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGG 78

                           90
                   ....*....|....
gi 1663450710  486 PSLCGNATVQVFVL 499
Cdd:pfam00028   79 PPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2642-2740 2.22e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 71.19  E-value: 2.22e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710 2642 SLSVPLPEDSPPGTVVAILSASDRDSGTNGQINCFLFPPGV--PFKLEStfkNYYSLIVGAVLDREQVAEYRMVVTVE** 2719
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEdgLFSIDP---STGEITTAKPLDREEQSSYTLTVTATDG 77

                           90       100
                   ....*....|....*....|.
gi 1663450710 2720 **PPLSSSISLLVPISDINDN 2740
Cdd:cd11304     78 GGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
1116-1206 3.16e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 70.79  E-value: 3.16e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710 1116 SVPLPEDSPPGTVVAILSATDRDSGTNGQINCFLFPPGVP--FKLEstfKNYYSLTVGAVLDREQVAEYRMVVTVEDQGV 1193
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGgnFRID---PDTGDISTTKPLDRESIGEYELTVEATDSGG 78

                           90
                   ....*....|...
gi 1663450710 1194 PPLSSSISLLVPI 1206
Cdd:pfam00028   79 PPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
1221-1314 3.41e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 70.79  E-value: 3.41e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710 1221 YTVFVKENNPPGAHIFTVSASDPDVAENALITYWIDEKlwPLSSYISVHSESGKLYALQSLDYEELKLLEFQVRAKDAGM 1300
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGG--GPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGG 78

                           90
                   ....*....|....
gi 1663450710 1301 PSLCGNATLQVFVL 1314
Cdd:pfam00028   79 PPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
2749-2842 5.89e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 70.02  E-value: 5.89e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710 2749 YTVFVKENNPPGAHIFTVSASDPDVAENALITYWI---DEKLWpltsyISVHSESGKLYALQSLDYEELKLLEFQVRAKD 2825
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIlggGPGGN-----FRIDPDTGDISTTKPLDRESIGEYELTVEATD 75

                           90
                   ....*....|....*..
gi 1663450710 2826 AGMPSLCGNATVQVFVL 2842
Cdd:pfam00028   76 SGGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
3434-3527 6.75e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 69.64  E-value: 6.75e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710 3434 YTVFVKENNPPGAYIFTVSASDPDVAENALITYWIGEKlwPLSSYISVHSESGKLYALQSLDYEELKLLEFQVRAKDAGM 3513
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGG--GPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGG 78

                           90
                   ....*....|....
gi 1663450710 3514 PSLCGNATVQVFVL 3527
Cdd:pfam00028   79 PPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2076-2132 9.45e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 69.65  E-value: 9.45e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1663450710 2076 SSYISVHSESGKLYALQSLDYEELKLLEFQVRAKDAGMPSLCGNATVQVFVLDENDN 2132
Cdd:cd11304     42 DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1340-1432 1.09e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 69.26  E-value: 1.09e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710 1340 PGHIVGKIHALDADSGYNAWLRYELVEESSVPW-SVGQYSGEVSTKYPL--EESeggKIQSVLVFVKDHGKPQLSATATL 1416
Cdd:cd11304     12 PGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLfSIDPSTGEITTAKPLdrEEQ---SSYTLTVTATDGGGPPLSSTATV 88

                           90
                   ....*....|....*.
gi 1663450710 1417 SVSLvtsgqtikTDIN 1432
Cdd:cd11304     89 TITV--------LDVN 96
Cadherin pfam00028
Cadherin domain;
301-391 5.70e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 66.94  E-value: 5.70e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710  301 SVPLPEDSPPGTVVAILSASDRDSGTNGQINCFLFPPGVP--FKLEstfKNYYSLIVGAVLDREQVAEYRMVVTVEDQGI 378
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGgnFRID---PDTGDISTTKPLDRESIGEYELTVEATDSGG 78

                           90
                   ....*....|...
gi 1663450710  379 PPLSSSISLLVPI 391
Cdd:pfam00028   79 PPLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1774-1828 5.72e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 66.60  E-value: 5.72e-13
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 1663450710  1774 SVQSESGKLYALQSLDYEELKLLEFQVRAKDAGMPSLCGNATVQVFVLDENDNTP 1828
Cdd:smart00112   27 SIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1774-1826 6.31e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 67.34  E-value: 6.31e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1663450710 1774 SVQSESGKLYALQSLDYEELKLLEFQVRAKDAGMPSLCGNATVQVFVLDENDN 1826
Cdd:cd11304     46 SIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
90-178 3.26e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 65.01  E-value: 3.26e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710   90 DIASGTRLLLEGASDADIGTNALLNYKLS---PNKYFALDTgndeddsKSVVLVLKVPLDREESPVHHLILTATDGGEPK 166
Cdd:pfam00028    8 NAPVGTEVLTVTATDPDLGPNGRIFYSILgggPGGNFRIDP-------DTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 1663450710  167 LTGTVQLVINVL 178
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 2365-2401 5.02e-12

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 64.09  E-value: 5.02e-12
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1663450710 2365 EVNLQNGILFVNSRIDREELCAKTADCVLHLEVIVEK 2401
Cdd:pfam08266   47 QLNPETGDLLLNEKLDREELCGSTEPCVLHFQVLLEN 83
Cadherin pfam00028
Cadherin domain;
2430-2521 8.07e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 63.86  E-value: 8.07e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710 2430 SISELI-TGTQFSLEGASDADIGTNALLNYKLS---PNNHFVLDSgndedgsKSVVLVLKVPLDREESPVHHLVLTATDG 2505
Cdd:pfam00028    4 SVPENApVGTEVLTVTATDPDLGPNGRIFYSILgggPGGNFRIDP-------DTGDISTTKPLDRESIGEYELTVEATDS 76

                           90
                   ....*....|....*.
gi 1663450710 2506 GEPKLTGTVQLIINVL 2521
Cdd:pfam00028   77 GGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
509-605 2.04e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 62.70  E-value: 2.04e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710  509 SGSSEENLVllvvpvmPGHIVGKIHALDADSGYNAWLRYELLE-ESSGPWSVGQYNGEVSTKYPLDESEGGKIqSVLILV 587
Cdd:pfam00028    2 SASVPENAP-------VGTEVLTVTATDPDLGPNGRIFYSILGgGPGGNFRIDPDTGDISTTKPLDRESIGEY-ELTVEA 73

                           90
                   ....*....|....*...
gi 1663450710  588 RDHGKPQLSATATLSVSL 605
Cdd:pfam00028   74 TDSGGPPLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2161-2234 5.61e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 61.21  E-value: 5.61e-11
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1663450710  2161 HALDADSGYNAWLRYELVEESSVPW-SVGQYSGEVSTKYPLDEsEGGKIQSIVVLVTDHGKPQLSATATLSVSLV 2234
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLfSIDPETGEITTTKPLDR-EEQPEYTLTVEATDGGGPPLSSTATVTITVL 74
Cadherin pfam00028
Cadherin domain;
2153-2233 8.13e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 61.16  E-value: 8.13e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710 2153 PGHIVGKIHALDADSGYNAWLRYELVE-ESSVPWSVGQYSGEVSTKYPLDESEGGKIqSIVVLVTDHGKPQLSATATLSV 2231
Cdd:pfam00028   11 VGTEVLTVTATDPDLGPNGRIFYSILGgGPGGNFRIDPDTGDISTTKPLDRESIGEY-ELTVEATDSGGPPLSSTATVTI 89


                   ..
gi 1663450710 2232 SL 2233
Cdd:pfam00028   90 TV 91
Cadherin pfam00028
Cadherin domain;
905-993 9.41e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 60.78  E-value: 9.41e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710  905 TTASGTRFPLEAASDADIGTNALLTHRLS---PNKYFALDTGNDEdgsksivLVLKVPLDREESSVHHLVLTATDGGEPK 981
Cdd:pfam00028    8 NAPVGTEVLTVTATDPDLGPNGRIFYSILgggPGGNFRIDPDTGD-------ISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 1663450710  982 LTGTVQLGINVL 993
Cdd:pfam00028   81 LSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 533-617 1.90e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 59.67  E-value: 1.90e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710   533 HALDADSGYNAWLRYELLEESSGPW-SVGQYNGEVSTKYPLDEsEGGKIQSVLILVRDHGKPQLSATATLSVSLvtsgqt 611
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLfSIDPETGEITTTKPLDR-EEQPEYTLTVEATDGGGPPLSSTATVTITV------ 73


                    ....*.
gi 1663450710   612 ikTDIN 617
Cdd:smart00112   74 --LDVN 77
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2876-2949 4.07e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 58.52  E-value: 4.07e-10
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1663450710  2876 HALDADSGYNAWLRYELVEESSVPW-SVGQYSGEVSTKYPLDEsEGGKIQSVLVLVKDHGKPQLSATATLSVSLV 2949
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLfSIDPETGEITTTKPLDR-EEQPEYTLTVEATDGGGPPLSSTATVTITVL 74
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1855-1939 4.28e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 58.52  E-value: 4.28e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710  1855 HALDADSGYNAWLRYELVEESSVPW-SVGQYNGEVSTKYPLDEsEGGKIQSVLVLVKDHGKPQLSATATLSVSLvtsgqt 1933
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLfSIDPETGEITTTKPLDR-EEQPEYTLTVEATDGGGPPLSSTATVTITV------ 73


                    ....*.
gi 1663450710  1934 ikTDIN 1939
Cdd:smart00112   74 --LDVN 77
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 8-40 7.06e-10

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 57.92  E-value: 7.06e-10
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1663450710    8 NNGILFVNSRIDREELCAKTADCVLHLEVIVEK 40
Cdd:pfam08266   51 ETGDLLLNEKLDREELCGSTEPCVLHFQVLLEN 83
Cadherin pfam00028
Cadherin domain;
1847-1927 1.16e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 57.70  E-value: 1.16e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710 1847 PGHIVGKIHALDADSGYNAWLRYELVE-ESSVPWSVGQYNGEVSTKYPLDESEGGKIqSVLVLVKDHGKPQLSATATLSV 1925
Cdd:pfam00028   11 VGTEVLTVTATDPDLGPNGRIFYSILGgGPGGNFRIDPDTGDISTTKPLDRESIGEY-ELTVEATDSGGPPLSSTATVTI 89


                   ..
gi 1663450710 1926 SL 1927
Cdd:pfam00028   90 TV 91
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 840-871 1.28e-09

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 57.15  E-value: 1.28e-09
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1663450710  840 NGILFVNSRIDREELCAKTADCVLHLEVIVEK 871
Cdd:pfam08266   52 TGDLLLNEKLDREELCGSTEPCVLHFQVLLEN 83
Cadherin pfam00028
Cadherin domain;
2868-2948 1.47e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 57.31  E-value: 1.47e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710 2868 PGHIVGKIHALDADSGYNAWLRYELVE-ESSVPWSVGQYSGEVSTKYPLDESEGGKIqSVLVLVKDHGKPQLSATATLSV 2946
Cdd:pfam00028   11 VGTEVLTVTATDPDLGPNGRIFYSILGgGPGGNFRIDPDTGDISTTKPLDRESIGEY-ELTVEATDSGGPPLSSTATVTI 89


                   ..
gi 1663450710 2947 SL 2948
Cdd:pfam00028   90 TV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1348-1432 8.33e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 55.05  E-value: 8.33e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710  1348 HALDADSGYNAWLRYELVEESSVPW-SVGQYSGEVSTKYPLEEsEGGKIQSVLVFVKDHGKPQLSATATLSVSLvtsgqt 1426
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLfSIDPETGEITTTKPLDR-EEQPEYTLTVEATDGGGPPLSSTATVTITV------ 73


                    ....*.
gi 1663450710  1427 ikTDIN 1432
Cdd:smart00112   74 --LDVN 77
Cadherin pfam00028
Cadherin domain;
3187-3281 1.22e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 55.00  E-value: 1.22e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710 3187 RQFTIAESSLHNSRFPLEGTSDADIAANSLLSYRL---NPNLLFSLVIETYEhsvflfLDLNKPLDREECAVHRLCLLAT 3263
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIlggGPGGNFRIDPDTGD------ISTTKPLDRESIGEYELTVEAT 74

                           90
                   ....*....|....*...
gi 1663450710 3264 DVGDPQLTGTVQLGIKVL 3281
Cdd:pfam00028   75 DSGGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
1340-1420 2.77e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 53.84  E-value: 2.77e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710 1340 PGHIVGKIHALDADSGYNAWLRYELVE-ESSVPWSVGQYSGEVSTKYPLEESEGGKIqSVLVFVKDHGKPQLSATATLSV 1418
Cdd:pfam00028   11 VGTEVLTVTATDPDLGPNGRIFYSILGgGPGGNFRIDPDTGDISTTKPLDRESIGEY-ELTVEATDSGGPPLSSTATVTI 89


                   ..
gi 1663450710 1419 SL 1420
Cdd:pfam00028   90 TV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3085-3178 5.30e-08

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 53.09  E-value: 5.30e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710 3085 MEESQQGTFVGHI-AQDLGLEVDELVSrmFQLVSKEQREYFQVNVQNGILFVNSQIDREKLyDKRAMCIVHLDALVEKPL 3163
Cdd:cd11304      7 PENAPPGTVVLTVsATDPDSGENGEVT--YSIVSGNEDGLFSIDPSTGEITTAKPLDREEQ-SSYTLTVTATDGGGPPLS 83

                           90
                   ....*....|....*
gi 1663450710 3164 RIFHIEVEIIDINDN 3178
Cdd:cd11304     84 STATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
2644-2716 2.69e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 51.15  E-value: 2.69e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1663450710 2644 SVPLPEDSPPGTVVAILSASDRDSGTNGQINCFLFPPGVP--FKLEstfKNYYSLIVGAVLDREQVAEYRMVVTV 2716
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGgnFRID---PDTGDISTTKPLDRESIGEYELTVEA 73
Cadherin_C_2 pfam16492
Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some ...
 2974-3004 2.06e-05

Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some proto-cadherins. It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. Cadherins are cell-surface receptors that function in cell adhesion, cell polarity, and tissue morphogenesis.


Pssm-ID: 465139  Cd Length: 84  Bit Score: 45.21  E-value: 2.06e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1663450710 2974 SINVYLIIAICSVSSLFLLAILIYVALRCHC 3004
Cdd:pfam16492    1 DLTFYLVIALASVSFLFLLFVIVLIALRLRR 31
Cadherin_C_2 pfam16492
Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some ...
 631-709 6.98e-05

Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some proto-cadherins. It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. Cadherins are cell-surface receptors that function in cell adhesion, cell polarity, and tissue morphogenesis.


Pssm-ID: 465139  Cd Length: 84  Bit Score: 44.05  E-value: 6.98e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710  631 SINIYLIIAICSVSSLFLLATLIYVALRCHCKAK------ESMVYGPGMATLVCASEVGSWSYSNRHSHILAGVSteagA 704
Cdd:pfam16492    1 DLTFYLVIALASVSFLFLLFVIVLIALRLRRWRSsallqsSGNLCSVPAPHFPGNDGTGTLPQSYSYEVCLTSDS----G 76


                   ....*
gi 1663450710  705 KSDLM 709
Cdd:pfam16492   77 KSEFK 81
Cadherin_C_2 pfam16492
Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some ...
 2259-2287 9.55e-05

Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some proto-cadherins. It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. Cadherins are cell-surface receptors that function in cell adhesion, cell polarity, and tissue morphogenesis.


Pssm-ID: 465139  Cd Length: 84  Bit Score: 43.67  E-value: 9.55e-05
                           10        20
                   ....*....|....*....|....*....
gi 1663450710 2259 SINIYLIIAICSVSSLFLLAVFVYMALRC 2287
Cdd:pfam16492    1 DLTFYLVIALASVSFLFLLFVIVLIALRL 29
Cadherin_C_2 pfam16492
Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some ...
 1446-1524 1.43e-04

Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some proto-cadherins. It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. Cadherins are cell-surface receptors that function in cell adhesion, cell polarity, and tissue morphogenesis.


Pssm-ID: 465139  Cd Length: 84  Bit Score: 42.90  E-value: 1.43e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710 1446 SINVYLIIAICSVSSLFLLATLIYMALRCHCKAK------ESMVYGPGMATLVCASEVGSWSYSNRHSHILAGVSteagA 1519
Cdd:pfam16492    1 DLTFYLVIALASVSFLFLLFVIVLIALRLRRWRSsallqsSGNLCSVPAPHFPGNDGTGTLPQSYSYEVCLTSDS----G 76


                   ....*
gi 1663450710 1520 KSDLM 1524
Cdd:pfam16492   77 KSEFK 81
Cadherin pfam00028
Cadherin domain;
2080-2127 1.69e-04

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 43.06  E-value: 1.69e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1663450710 2080 SVHSESGKLYALQSLDYEELKLLEFQVRAKDAGMPSLCGNATVQVFVL 2127
Cdd:pfam00028   45 RIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
1774-1821 2.60e-04

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 42.67  E-value: 2.60e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1663450710 1774 SVQSESGKLYALQSLDYEELKLLEFQVRAKDAGMPSLCGNATVQVFVL 1821
Cdd:pfam00028   45 RIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3113-3180 3.45e-04

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 41.95  E-value: 3.45e-04
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1663450710  3113 FQLVSKEQREYFQVNVQNGILFVNSQIDREKlydkraMCIVHLDALV----EKPLRIF-HIEVEIIDINDNAP 3180
Cdd:smart00112   15 YSILSGNDDGLFSIDPETGEITTTKPLDREE------QPEYTLTVEAtdggGPPLSSTaTVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2365-2420 2.38e-03

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 39.64  E-value: 2.38e-03
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1663450710  2365 EVNLQNGILFVNSRIDREELCaktadcVLHLEVIV----EKPLR-FFHVEVEVKDMNDNAP 2420
Cdd:smart00112   27 SIDPETGEITTTKPLDREEQP------EYTLTVEAtdggGPPLSsTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 8-59 5.26e-03

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 38.48  E-value: 5.26e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 1663450710     8 NNGILFVNSRIDREELCaktadcVLHLEVIV----EKPLR-FFHVEVEVKDMNDNAP 59
Cdd:smart00112   31 ETGEITTTKPLDREEQP------EYTLTVEAtdggGPPLSsTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 837-890 7.13e-03

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 38.10  E-value: 7.13e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 1663450710   837 EQINGILFVNSRIDREELCaktadcVLHLEVIV----EKPLR-FFHVEVEVKDMNDNAP 890
Cdd:smart00112   29 DPETGEITTTKPLDREEQP------EYTLTVEAtdggGPPLSsTATVTITVLDVNDNAP 81
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2534-2634 2.27e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 119.73  E-value: 2.27e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710 2534 VYRIKLLENTASGSLVIILNATDIDEGINREISYFFTYSlalHVTKMFSINSDTGEIRVIGKLDYEESKFYELPIVAEDK 2613
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSG---NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                           90       100
                   ....*....|....*....|.
gi 1663450710 2614 GNSPLSGHCKVLIDVLDINDN 2634
Cdd:cd11304     78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 191-291 2.00e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 117.03  E-value: 2.00e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710  191 VYRVKLLENSASGSLVITLNATDLDEGINREIFYSFHDSVPLHvtkLFSINSDTGEIRVIGKLDYEKSKFYELPIVAEDK 270
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDG---LFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                           90       100
                   ....*....|....*....|.
gi 1663450710  271 GNSPLLGHCKVLIEMLDMNDN 291
Cdd:cd11304     78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1006-1106 5.93e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 112.79  E-value: 5.93e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710 1006 VYRIKLLENIASESLVITLNATDLDEGINREILYFFsnkVPTHVSELFSINSDTGKIRVIGKLDYEESMFYELPIVAEDK 1085
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI---VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                           90       100
                   ....*....|....*....|.
gi 1663450710 1086 GNSPLFGHCKVLIEVLDMNDN 1106
Cdd:cd11304     78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3294-3393 1.29e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 108.94  E-value: 1.29e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710 3294 VYNVQILENSE-NEVIFKVNATDLDEGTNREITYissNFSPTNGKEKIILDHQTGEIYVKGHLDFEERNFYEIHVEAKDN 3372
Cdd:cd11304      1 SYEVSVPENAPpGTVVLTVSATDPDSGENGEVTY---SIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                           90       100
                   ....*....|....*....|.
gi 1663450710 3373 RNPPLSGHCKVLIEILDLNDN 3393
Cdd:cd11304     78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 405-504 4.39e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.40  E-value: 4.39e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710  405 SYTVFVKENNPPGAHIFTVSASDPDVAENALITYWIDEKlwPLSSYISVHSESGKLYALQSLDYEELKLLEFQVRAKDAG 484
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSG--NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                           90       100
                   ....*....|....*....|
gi 1663450710  485 MPSLCGNATVQVFVLDENDN 504
Cdd:cd11304     79 GPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2748-2847 7.71e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.01  E-value: 7.71e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710 2748 SYTVFVKENNPPGAHIFTVSASDPDVAENALITYWIDEKlwPLTSYISVHSESGKLYALQSLDYEELKLLEFQVRAKDAG 2827
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSG--NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                           90       100
                   ....*....|....*....|
gi 1663450710 2828 MPSLCGNATVQVFVLDENDN 2847
Cdd:cd11304     79 GPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1220-1319 1.22e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 106.24  E-value: 1.22e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710 1220 SYTVFVKENNPPGAHIFTVSASDPDVAENALITYWIDEKlwPLSSYISVHSESGKLYALQSLDYEELKLLEFQVRAKDAG 1299
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSG--NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                           90       100
                   ....*....|....*....|
gi 1663450710 1300 MPSLCGNATLQVFVLDENDN 1319
Cdd:cd11304     79 GPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3433-3532 1.29e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 106.24  E-value: 1.29e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710 3433 SYTVFVKENNPPGAYIFTVSASDPDVAENALITYWIGEKlwPLSSYISVHSESGKLYALQSLDYEELKLLEFQVRAKDAG 3512
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSG--NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                           90       100
                   ....*....|....*....|
gi 1663450710 3513 MPSLCGNATVQVFVLDENDN 3532
Cdd:cd11304     79 GPPLSSTATVTITVLDVNDN 98
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 3085-3161 4.87e-25

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 101.06  E-value: 4.87e-25
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1663450710 3085 MEESQQGTFVGHIAQDLGLEVDELVSRMFQLVSKEQREYFQVNVQNGILFVNSQIDREKLYDKRAMCIVHLDALVEK 3161
Cdd:pfam08266    7 PEETERGSFVGNLAKDLGLEVGELAARGARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVLLEN 83
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1114-1212 1.00e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 100.85  E-value: 1.00e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710 1114 SLSVPLPEDSPPGTVVAILSATDRDSGTNGQINCFLFPPGV--PFKLEStfkNYYSLTVGAVLDREQVAEYRMVVTVEDQ 1191
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEdgLFSIDP---STGEITTAKPLDREEQSSYTLTVTATDG 77

                           90       100
                   ....*....|....*....|.
gi 1663450710 1192 GVPPLSSSISLLVPISDINDN 1212
Cdd:cd11304     78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 299-397 6.18e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 98.54  E-value: 6.18e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710  299 SLSVPLPEDSPPGTVVAILSASDRDSGTNGQINCFLFPPGV--PFKLEStfkNYYSLIVGAVLDREQVAEYRMVVTVEDQ 376
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEdgLFSIDP---STGEITTAKPLDREEQSSYTLTVTATDG 77

                           90       100
                   ....*....|....*....|.
gi 1663450710  377 GIPPLSSSISLLVPISDINDN 397
Cdd:cd11304     78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 90-183 1.45e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 97.38  E-value: 1.45e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710   90 DIASGTRLLLEGASDADIGTNALLNYKLS---PNKYFALDtgndeddSKSVVLVLKVPLDREESPVHHLILTATDGGEPK 166
Cdd:cd11304      9 NAPPGTVVLTVSATDPDSGENGEVTYSIVsgnEDGLFSID-------PSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|....*..
gi 1663450710  167 LTGTVQLVINVLDVNDN 183
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2445-2528 2.73e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 96.26  E-value: 2.73e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710  2445 ASDADIGTNALLNYKLSPNNHFVLDSGNDEDGsksvVLVLKVPLDREESPVHHLVLTATDGGEPKLTGTVQLIINVLDVN 2524
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPETG----EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 1663450710  2525 DNPP 2528
Cdd:smart00112   78 DNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2553-2636 2.73e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 96.26  E-value: 2.73e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710  2553 NATDIDEGINREISYFFTYSlalHVTKMFSINSDTGEIRVIGKLDYEESKFYELPIVAEDKGNSPLSGHCKVLIDVLDIN 2632
Cdd:smart00112    1 SATDADSGENGKVTYSILSG---NDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 1663450710  2633 DNIP 2636
Cdd:smart00112   78 DNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2426-2526 1.33e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 94.69  E-value: 1.33e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710 2426 EQILSISE-LITGTQFSLEGASDADIGTNALLNYKLSPNN---HFVLDSgndedgsKSVVLVLKVPLDREESPVHHLVLT 2501
Cdd:cd11304      1 SYEVSVPEnAPPGTVVLTVSATDPDSGENGEVTYSIVSGNedgLFSIDP-------STGEITTAKPLDREEQSSYTLTVT 73

                           90       100
                   ....*....|....*....|....*
gi 1663450710 2502 ATDGGEPKLTGTVQLIINVLDVNDN 2526
Cdd:cd11304     74 ATDGGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 210-293 2.94e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 93.18  E-value: 2.94e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710   210 NATDLDEGINREIFYSFHDSVPLHvtkLFSINSDTGEIRVIGKLDYEKSKFYELPIVAEDKGNSPLLGHCKVLIEMLDMN 289
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDG---LFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 1663450710   290 DNIP 293
Cdd:smart00112   78 DNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 102-185 3.71e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 92.80  E-value: 3.71e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710   102 ASDADIGTNALLNYKLSPN---KYFALDtgndeddSKSVVLVLKVPLDREESPVHHLILTATDGGEPKLTGTVQLVINVL 178
Cdd:smart00112    2 ATDADSGENGKVTYSILSGnddGLFSID-------PETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74


                    ....*..
gi 1663450710   179 DVNDNPP 185
Cdd:smart00112   75 DVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1025-1108 2.73e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 90.49  E-value: 2.73e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710  1025 NATDLDEGINREILYFFsnkVPTHVSELFSINSDTGKIRVIGKLDYEESMFYELPIVAEDKGNSPLFGHCKVLIEVLDMN 1104
Cdd:smart00112    1 SATDADSGENGKVTYSI---LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 1663450710  1105 DNIP 1108
Cdd:smart00112   78 DNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3312-3395 7.88e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 88.95  E-value: 7.88e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710  3312 NATDLDEGTNREITYissNFSPTNGKEKIILDHQTGEIYVKGHLDFEERNFYEIHVEAKDNRNPPLSGHCKVLIEILDLN 3391
Cdd:smart00112    1 SATDADSGENGKVTY---SILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 1663450710  3392 DNPP 3395
Cdd:smart00112   78 DNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 917-1000 2.13e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 87.79  E-value: 2.13e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710   917 ASDADIGTNALLTHRLSPN---KYFALDtgndedgSKSIVLVLKVPLDREESSVHHLVLTATDGGEPKLTGTVQLGINVL 993
Cdd:smart00112    2 ATDADSGENGKVTYSILSGnddGLFSID-------PETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74


                    ....*..
gi 1663450710   994 DINDNPP 1000
Cdd:smart00112   75 DVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 906-998 2.59e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.14  E-value: 2.59e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710  906 TASGTRFPLEAASDADIGTNALLTHRLS---PNKYFALD--TGndedgsksiVLVLKVPLDREESSVHHLVLTATDGGEP 980
Cdd:cd11304     10 APPGTVVLTVSATDPDSGENGEVTYSIVsgnEDGLFSIDpsTG---------EITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 1663450710  981 KLTGTVQLGINVLDINDN 998
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2767-2849 7.18e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 86.25  E-value: 7.18e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710  2767 SASDPDVAENALITYWIDEKlwPLTSYISVHSESGKLYALQSLDYEELKLLEFQVRAKDAGMPSLCGNATVQVFVLDEND 2846
Cdd:smart00112    1 SATDADSGENGKVTYSILSG--NDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVND 78


                    ...
gi 1663450710  2847 NAP 2849
Cdd:smart00112   79 NAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1239-1321 1.43e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 85.48  E-value: 1.43e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710  1239 SASDPDVAENALITYWIDEKlwPLSSYISVHSESGKLYALQSLDYEELKLLEFQVRAKDAGMPSLCGNATLQVFVLDEND 1318
Cdd:smart00112    1 SATDADSGENGKVTYSILSG--NDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVND 78


                    ...
gi 1663450710  1319 NAP 1321
Cdd:smart00112   79 NAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3452-3534 1.45e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 85.48  E-value: 1.45e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710  3452 SASDPDVAENALITYWIGEKlwPLSSYISVHSESGKLYALQSLDYEELKLLEFQVRAKDAGMPSLCGNATVQVFVLDEND 3531
Cdd:smart00112    1 SATDADSGENGKVTYSILSG--NDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVND 78


                    ...
gi 1663450710  3532 NAP 3534
Cdd:smart00112   79 NAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 424-506 2.97e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 84.71  E-value: 2.97e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710   424 SASDPDVAENALITYWIDEKlwPLSSYISVHSESGKLYALQSLDYEELKLLEFQVRAKDAGMPSLCGNATVQVFVLDEND 503
Cdd:smart00112    1 SATDADSGENGKVTYSILSG--NDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVND 78


                    ...
gi 1663450710   504 NTP 506
Cdd:smart00112   79 NAP 81
Cadherin pfam00028
Cadherin domain;
2535-2629 1.01e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 83.50  E-value: 1.01e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710 2535 YRIKLLENTASGSLVIILNATDIDEGINREISYFFTYSlalHVTKMFSINSDTGEIRVIGKLDYEESKFYELPIVAEDKG 2614
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGG---GPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                           90
                   ....*....|....*
gi 1663450710 2615 NSPLSGHCKVLIDVL 2629
Cdd:pfam00028   78 GPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1133-1214 5.77e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 78.16  E-value: 5.77e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710  1133 SATDRDSGTNGQINCFLFPPGV--PFKLEStfkNYYSLTVGAVLDREQVAEYRMVVTVEDQGVPPLSSSISLLVPISDIN 1210
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDdgLFSIDP---ETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 1663450710  1211 DNAP 1214
Cdd:smart00112   78 DNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3188-3286 1.12e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 77.74  E-value: 1.12e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710 3188 QFTIAESSLHNSRFPLEGTSDADIAANSLLSYRL---NPNLLFSLVIETYEhsvflfLDLNKPLDREECAVHRLCLLATD 3264
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvsgNEDGLFSIDPSTGE------ITTAKPLDREEQSSYTLTVTATD 76

                           90       100
                   ....*....|....*....|..
gi 1663450710 3265 VGDPQLTGTVQLGIKVLDANDN 3286
Cdd:cd11304     77 GGGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
192-284 1.41e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 77.34  E-value: 1.41e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710  192 YRVKLLENSASGSLVITLNATDLDEGINREIFYSFhdsVPLHVTKLFSINSDTGEIRVIGKLDYEKSKFYELPIVAEDKG 271
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSI---LGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                           90
                   ....*....|...
gi 1663450710  272 NSPLLGHCKVLIE 284
Cdd:pfam00028   78 GPPLSSTATVTIT 90
Cadherin pfam00028
Cadherin domain;
1007-1101 1.67e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 77.34  E-value: 1.67e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710 1007 YRIKLLENIASESLVITLNATDLDEGINREILYFFSNkvpTHVSELFSINSDTGKIRVIGKLDYEESMFYELPIVAEDKG 1086
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILG---GGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                           90
                   ....*....|....*
gi 1663450710 1087 NSPLFGHCKVLIEVL 1101
Cdd:pfam00028   78 GPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2153-2234 2.03e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 76.97  E-value: 2.03e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710 2153 PGHIVGKIHALDADSGYNAWLRYELVEESSVPW-SVGQYSGEVSTKYPLDeSEGGKIQSIVVLVTDHGKPQLSATATLSV 2231
Cdd:cd11304     12 PGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLfSIDPSTGEITTAKPLD-REEQSSYTLTVTATDGGGPPLSSTATVTI 90


                   ...
gi 1663450710 2232 SLV 2234
Cdd:cd11304     91 TVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 525-617 1.17e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.04  E-value: 1.17e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710  525 PGHIVGKIHALDADSGYNAWLRYELLEESSGPW-SVGQYNGEVSTKYPLDeSEGGKIQSVLILVRDHGKPQLSATATLSV 603
Cdd:cd11304     12 PGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLfSIDPSTGEITTAKPLD-REEQSSYTLTVTATDGGGPPLSSTATVTI 90

                           90
                   ....*....|....
gi 1663450710  604 SLvtsgqtikTDIN 617
Cdd:cd11304     91 TV--------LDVN 96
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1847-1939 1.23e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.04  E-value: 1.23e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710 1847 PGHIVGKIHALDADSGYNAWLRYELVEESSVPW-SVGQYNGEVSTKYPLDeSEGGKIQSVLVLVKDHGKPQLSATATLSV 1925
Cdd:cd11304     12 PGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLfSIDPSTGEITTAKPLD-REEQSSYTLTVTATDGGGPPLSSTATVTI 90

                           90
                   ....*....|....
gi 1663450710 1926 SLvtsgqtikTDIN 1939
Cdd:cd11304     91 TV--------LDVN 96
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2868-2949 1.24e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.04  E-value: 1.24e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710 2868 PGHIVGKIHALDADSGYNAWLRYELVEESSVPW-SVGQYSGEVSTKYPLDeSEGGKIQSVLVLVKDHGKPQLSATATLSV 2946
Cdd:cd11304     12 PGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLfSIDPSTGEITTAKPLD-REEQSSYTLTVTATDGGGPPLSSTATVTI 90


                   ...
gi 1663450710 2947 SLV 2949
Cdd:cd11304     91 TVL 93
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 318-399 2.43e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 73.54  E-value: 2.43e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710   318 SASDRDSGTNGQINCFLFPPGV--PFKLEStfkNYYSLIVGAVLDREQVAEYRMVVTVEDQGIPPLSSSISLLVPISDIN 395
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDdgLFSIDP---ETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 1663450710   396 DNVP 399
Cdd:smart00112   78 DNAP 81
Cadherin pfam00028
Cadherin domain;
3295-3388 5.21e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 73.10  E-value: 5.21e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710 3295 YNVQILENS-ENEVIFKVNATDLDEGTNREITYissNFSPTNGKEKIILDHQTGEIYVKGHLDFEERNFYEIHVEAKDNR 3373
Cdd:pfam00028    1 YSASVPENApVGTEVLTVTATDPDLGPNGRIFY---SILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                           90
                   ....*....|....*
gi 1663450710 3374 NPPLSGHCKVLIEIL 3388
Cdd:pfam00028   78 GPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3207-3288 7.32e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 72.00  E-value: 7.32e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710  3207 SDADIAANSLLSYRL---NPNLLFSLVIETYEHSVflfldlNKPLDREECAVHRLCLLATDVGDPQLTGTVQLGIKVLDA 3283
Cdd:smart00112    3 TDADSGENGKVTYSIlsgNDDGLFSIDPETGEITT------TKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDV 76


                    ....*
gi 1663450710  3284 NDNLP 3288
Cdd:smart00112   77 NDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2076-2134 1.92e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 70.84  E-value: 1.92e-14
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 1663450710  2076 SSYISVHSESGKLYALQSLDYEELKLLEFQVRAKDAGMPSLCGNATVQVFVLDENDNAP 2134
Cdd:smart00112   23 DGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
406-499 2.12e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.18  E-value: 2.12e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710  406 YTVFVKENNPPGAHIFTVSASDPDVAENALITYWIDEKlwPLSSYISVHSESGKLYALQSLDYEELKLLEFQVRAKDAGM 485
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGG--GPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGG 78

                           90
                   ....*....|....
gi 1663450710  486 PSLCGNATVQVFVL 499
Cdd:pfam00028   79 PPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2642-2740 2.22e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 71.19  E-value: 2.22e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710 2642 SLSVPLPEDSPPGTVVAILSASDRDSGTNGQINCFLFPPGV--PFKLEStfkNYYSLIVGAVLDREQVAEYRMVVTVE** 2719
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEdgLFSIDP---STGEITTAKPLDREEQSSYTLTVTATDG 77

                           90       100
                   ....*....|....*....|.
gi 1663450710 2720 **PPLSSSISLLVPISDINDN 2740
Cdd:cd11304     78 GGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
1116-1206 3.16e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 70.79  E-value: 3.16e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710 1116 SVPLPEDSPPGTVVAILSATDRDSGTNGQINCFLFPPGVP--FKLEstfKNYYSLTVGAVLDREQVAEYRMVVTVEDQGV 1193
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGgnFRID---PDTGDISTTKPLDRESIGEYELTVEATDSGG 78

                           90
                   ....*....|...
gi 1663450710 1194 PPLSSSISLLVPI 1206
Cdd:pfam00028   79 PPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
1221-1314 3.41e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 70.79  E-value: 3.41e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710 1221 YTVFVKENNPPGAHIFTVSASDPDVAENALITYWIDEKlwPLSSYISVHSESGKLYALQSLDYEELKLLEFQVRAKDAGM 1300
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGG--GPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGG 78

                           90
                   ....*....|....
gi 1663450710 1301 PSLCGNATLQVFVL 1314
Cdd:pfam00028   79 PPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
2749-2842 5.89e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 70.02  E-value: 5.89e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710 2749 YTVFVKENNPPGAHIFTVSASDPDVAENALITYWI---DEKLWpltsyISVHSESGKLYALQSLDYEELKLLEFQVRAKD 2825
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIlggGPGGN-----FRIDPDTGDISTTKPLDRESIGEYELTVEATD 75

                           90
                   ....*....|....*..
gi 1663450710 2826 AGMPSLCGNATVQVFVL 2842
Cdd:pfam00028   76 SGGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
3434-3527 6.75e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 69.64  E-value: 6.75e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710 3434 YTVFVKENNPPGAYIFTVSASDPDVAENALITYWIGEKlwPLSSYISVHSESGKLYALQSLDYEELKLLEFQVRAKDAGM 3513
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGG--GPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGG 78

                           90
                   ....*....|....
gi 1663450710 3514 PSLCGNATVQVFVL 3527
Cdd:pfam00028   79 PPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2076-2132 9.45e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 69.65  E-value: 9.45e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1663450710 2076 SSYISVHSESGKLYALQSLDYEELKLLEFQVRAKDAGMPSLCGNATVQVFVLDENDN 2132
Cdd:cd11304     42 DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1340-1432 1.09e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 69.26  E-value: 1.09e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710 1340 PGHIVGKIHALDADSGYNAWLRYELVEESSVPW-SVGQYSGEVSTKYPL--EESeggKIQSVLVFVKDHGKPQLSATATL 1416
Cdd:cd11304     12 PGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLfSIDPSTGEITTAKPLdrEEQ---SSYTLTVTATDGGGPPLSSTATV 88

                           90
                   ....*....|....*.
gi 1663450710 1417 SVSLvtsgqtikTDIN 1432
Cdd:cd11304     89 TITV--------LDVN 96
Cadherin pfam00028
Cadherin domain;
301-391 5.70e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 66.94  E-value: 5.70e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710  301 SVPLPEDSPPGTVVAILSASDRDSGTNGQINCFLFPPGVP--FKLEstfKNYYSLIVGAVLDREQVAEYRMVVTVEDQGI 378
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGgnFRID---PDTGDISTTKPLDRESIGEYELTVEATDSGG 78

                           90
                   ....*....|...
gi 1663450710  379 PPLSSSISLLVPI 391
Cdd:pfam00028   79 PPLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1774-1828 5.72e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 66.60  E-value: 5.72e-13
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 1663450710  1774 SVQSESGKLYALQSLDYEELKLLEFQVRAKDAGMPSLCGNATVQVFVLDENDNTP 1828
Cdd:smart00112   27 SIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1774-1826 6.31e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 67.34  E-value: 6.31e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1663450710 1774 SVQSESGKLYALQSLDYEELKLLEFQVRAKDAGMPSLCGNATVQVFVLDENDN 1826
Cdd:cd11304     46 SIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
90-178 3.26e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 65.01  E-value: 3.26e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710   90 DIASGTRLLLEGASDADIGTNALLNYKLS---PNKYFALDTgndeddsKSVVLVLKVPLDREESPVHHLILTATDGGEPK 166
Cdd:pfam00028    8 NAPVGTEVLTVTATDPDLGPNGRIFYSILgggPGGNFRIDP-------DTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 1663450710  167 LTGTVQLVINVL 178
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 2365-2401 5.02e-12

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 64.09  E-value: 5.02e-12
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1663450710 2365 EVNLQNGILFVNSRIDREELCAKTADCVLHLEVIVEK 2401
Cdd:pfam08266   47 QLNPETGDLLLNEKLDREELCGSTEPCVLHFQVLLEN 83
Cadherin pfam00028
Cadherin domain;
2430-2521 8.07e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 63.86  E-value: 8.07e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710 2430 SISELI-TGTQFSLEGASDADIGTNALLNYKLS---PNNHFVLDSgndedgsKSVVLVLKVPLDREESPVHHLVLTATDG 2505
Cdd:pfam00028    4 SVPENApVGTEVLTVTATDPDLGPNGRIFYSILgggPGGNFRIDP-------DTGDISTTKPLDRESIGEYELTVEATDS 76

                           90
                   ....*....|....*.
gi 1663450710 2506 GEPKLTGTVQLIINVL 2521
Cdd:pfam00028   77 GGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
509-605 2.04e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 62.70  E-value: 2.04e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710  509 SGSSEENLVllvvpvmPGHIVGKIHALDADSGYNAWLRYELLE-ESSGPWSVGQYNGEVSTKYPLDESEGGKIqSVLILV 587
Cdd:pfam00028    2 SASVPENAP-------VGTEVLTVTATDPDLGPNGRIFYSILGgGPGGNFRIDPDTGDISTTKPLDRESIGEY-ELTVEA 73

                           90
                   ....*....|....*...
gi 1663450710  588 RDHGKPQLSATATLSVSL 605
Cdd:pfam00028   74 TDSGGPPLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2161-2234 5.61e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 61.21  E-value: 5.61e-11
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1663450710  2161 HALDADSGYNAWLRYELVEESSVPW-SVGQYSGEVSTKYPLDEsEGGKIQSIVVLVTDHGKPQLSATATLSVSLV 2234
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLfSIDPETGEITTTKPLDR-EEQPEYTLTVEATDGGGPPLSSTATVTITVL 74
Cadherin pfam00028
Cadherin domain;
2153-2233 8.13e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 61.16  E-value: 8.13e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710 2153 PGHIVGKIHALDADSGYNAWLRYELVE-ESSVPWSVGQYSGEVSTKYPLDESEGGKIqSIVVLVTDHGKPQLSATATLSV 2231
Cdd:pfam00028   11 VGTEVLTVTATDPDLGPNGRIFYSILGgGPGGNFRIDPDTGDISTTKPLDRESIGEY-ELTVEATDSGGPPLSSTATVTI 89


                   ..
gi 1663450710 2232 SL 2233
Cdd:pfam00028   90 TV 91
Cadherin pfam00028
Cadherin domain;
905-993 9.41e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 60.78  E-value: 9.41e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710  905 TTASGTRFPLEAASDADIGTNALLTHRLS---PNKYFALDTGNDEdgsksivLVLKVPLDREESSVHHLVLTATDGGEPK 981
Cdd:pfam00028    8 NAPVGTEVLTVTATDPDLGPNGRIFYSILgggPGGNFRIDPDTGD-------ISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 1663450710  982 LTGTVQLGINVL 993
Cdd:pfam00028   81 LSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 533-617 1.90e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 59.67  E-value: 1.90e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710   533 HALDADSGYNAWLRYELLEESSGPW-SVGQYNGEVSTKYPLDEsEGGKIQSVLILVRDHGKPQLSATATLSVSLvtsgqt 611
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLfSIDPETGEITTTKPLDR-EEQPEYTLTVEATDGGGPPLSSTATVTITV------ 73


                    ....*.
gi 1663450710   612 ikTDIN 617
Cdd:smart00112   74 --LDVN 77
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2876-2949 4.07e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 58.52  E-value: 4.07e-10
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1663450710  2876 HALDADSGYNAWLRYELVEESSVPW-SVGQYSGEVSTKYPLDEsEGGKIQSVLVLVKDHGKPQLSATATLSVSLV 2949
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLfSIDPETGEITTTKPLDR-EEQPEYTLTVEATDGGGPPLSSTATVTITVL 74
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1855-1939 4.28e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 58.52  E-value: 4.28e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710  1855 HALDADSGYNAWLRYELVEESSVPW-SVGQYNGEVSTKYPLDEsEGGKIQSVLVLVKDHGKPQLSATATLSVSLvtsgqt 1933
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLfSIDPETGEITTTKPLDR-EEQPEYTLTVEATDGGGPPLSSTATVTITV------ 73


                    ....*.
gi 1663450710  1934 ikTDIN 1939
Cdd:smart00112   74 --LDVN 77
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 8-40 7.06e-10

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 57.92  E-value: 7.06e-10
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1663450710    8 NNGILFVNSRIDREELCAKTADCVLHLEVIVEK 40
Cdd:pfam08266   51 ETGDLLLNEKLDREELCGSTEPCVLHFQVLLEN 83
Cadherin pfam00028
Cadherin domain;
1847-1927 1.16e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 57.70  E-value: 1.16e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710 1847 PGHIVGKIHALDADSGYNAWLRYELVE-ESSVPWSVGQYNGEVSTKYPLDESEGGKIqSVLVLVKDHGKPQLSATATLSV 1925
Cdd:pfam00028   11 VGTEVLTVTATDPDLGPNGRIFYSILGgGPGGNFRIDPDTGDISTTKPLDRESIGEY-ELTVEATDSGGPPLSSTATVTI 89


                   ..
gi 1663450710 1926 SL 1927
Cdd:pfam00028   90 TV 91
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 840-871 1.28e-09

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 57.15  E-value: 1.28e-09
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1663450710  840 NGILFVNSRIDREELCAKTADCVLHLEVIVEK 871
Cdd:pfam08266   52 TGDLLLNEKLDREELCGSTEPCVLHFQVLLEN 83
Cadherin pfam00028
Cadherin domain;
2868-2948 1.47e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 57.31  E-value: 1.47e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710 2868 PGHIVGKIHALDADSGYNAWLRYELVE-ESSVPWSVGQYSGEVSTKYPLDESEGGKIqSVLVLVKDHGKPQLSATATLSV 2946
Cdd:pfam00028   11 VGTEVLTVTATDPDLGPNGRIFYSILGgGPGGNFRIDPDTGDISTTKPLDRESIGEY-ELTVEATDSGGPPLSSTATVTI 89


                   ..
gi 1663450710 2947 SL 2948
Cdd:pfam00028   90 TV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1348-1432 8.33e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 55.05  E-value: 8.33e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710  1348 HALDADSGYNAWLRYELVEESSVPW-SVGQYSGEVSTKYPLEEsEGGKIQSVLVFVKDHGKPQLSATATLSVSLvtsgqt 1426
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLfSIDPETGEITTTKPLDR-EEQPEYTLTVEATDGGGPPLSSTATVTITV------ 73


                    ....*.
gi 1663450710  1427 ikTDIN 1432
Cdd:smart00112   74 --LDVN 77
Cadherin pfam00028
Cadherin domain;
3187-3281 1.22e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 55.00  E-value: 1.22e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710 3187 RQFTIAESSLHNSRFPLEGTSDADIAANSLLSYRL---NPNLLFSLVIETYEhsvflfLDLNKPLDREECAVHRLCLLAT 3263
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIlggGPGGNFRIDPDTGD------ISTTKPLDRESIGEYELTVEAT 74

                           90
                   ....*....|....*...
gi 1663450710 3264 DVGDPQLTGTVQLGIKVL 3281
Cdd:pfam00028   75 DSGGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
1340-1420 2.77e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 53.84  E-value: 2.77e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710 1340 PGHIVGKIHALDADSGYNAWLRYELVE-ESSVPWSVGQYSGEVSTKYPLEESEGGKIqSVLVFVKDHGKPQLSATATLSV 1418
Cdd:pfam00028   11 VGTEVLTVTATDPDLGPNGRIFYSILGgGPGGNFRIDPDTGDISTTKPLDRESIGEY-ELTVEATDSGGPPLSSTATVTI 89


                   ..
gi 1663450710 1419 SL 1420
Cdd:pfam00028   90 TV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3085-3178 5.30e-08

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 53.09  E-value: 5.30e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710 3085 MEESQQGTFVGHI-AQDLGLEVDELVSrmFQLVSKEQREYFQVNVQNGILFVNSQIDREKLyDKRAMCIVHLDALVEKPL 3163
Cdd:cd11304      7 PENAPPGTVVLTVsATDPDSGENGEVT--YSIVSGNEDGLFSIDPSTGEITTAKPLDREEQ-SSYTLTVTATDGGGPPLS 83

                           90
                   ....*....|....*
gi 1663450710 3164 RIFHIEVEIIDINDN 3178
Cdd:cd11304     84 STATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
2644-2716 2.69e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 51.15  E-value: 2.69e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1663450710 2644 SVPLPEDSPPGTVVAILSASDRDSGTNGQINCFLFPPGVP--FKLEstfKNYYSLIVGAVLDREQVAEYRMVVTV 2716
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGgnFRID---PDTGDISTTKPLDRESIGEYELTVEA 73
Cadherin_C_2 pfam16492
Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some ...
 2974-3004 2.06e-05

Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some proto-cadherins. It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. Cadherins are cell-surface receptors that function in cell adhesion, cell polarity, and tissue morphogenesis.


Pssm-ID: 465139  Cd Length: 84  Bit Score: 45.21  E-value: 2.06e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1663450710 2974 SINVYLIIAICSVSSLFLLAILIYVALRCHC 3004
Cdd:pfam16492    1 DLTFYLVIALASVSFLFLLFVIVLIALRLRR 31
Cadherin_C_2 pfam16492
Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some ...
 631-709 6.98e-05

Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some proto-cadherins. It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. Cadherins are cell-surface receptors that function in cell adhesion, cell polarity, and tissue morphogenesis.


Pssm-ID: 465139  Cd Length: 84  Bit Score: 44.05  E-value: 6.98e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710  631 SINIYLIIAICSVSSLFLLATLIYVALRCHCKAK------ESMVYGPGMATLVCASEVGSWSYSNRHSHILAGVSteagA 704
Cdd:pfam16492    1 DLTFYLVIALASVSFLFLLFVIVLIALRLRRWRSsallqsSGNLCSVPAPHFPGNDGTGTLPQSYSYEVCLTSDS----G 76


                   ....*
gi 1663450710  705 KSDLM 709
Cdd:pfam16492   77 KSEFK 81
Cadherin_C_2 pfam16492
Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some ...
 2259-2287 9.55e-05

Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some proto-cadherins. It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. Cadherins are cell-surface receptors that function in cell adhesion, cell polarity, and tissue morphogenesis.


Pssm-ID: 465139  Cd Length: 84  Bit Score: 43.67  E-value: 9.55e-05
                           10        20
                   ....*....|....*....|....*....
gi 1663450710 2259 SINIYLIIAICSVSSLFLLAVFVYMALRC 2287
Cdd:pfam16492    1 DLTFYLVIALASVSFLFLLFVIVLIALRL 29
Cadherin_C_2 pfam16492
Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some ...
 1446-1524 1.43e-04

Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some proto-cadherins. It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. Cadherins are cell-surface receptors that function in cell adhesion, cell polarity, and tissue morphogenesis.


Pssm-ID: 465139  Cd Length: 84  Bit Score: 42.90  E-value: 1.43e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663450710 1446 SINVYLIIAICSVSSLFLLATLIYMALRCHCKAK------ESMVYGPGMATLVCASEVGSWSYSNRHSHILAGVSteagA 1519
Cdd:pfam16492    1 DLTFYLVIALASVSFLFLLFVIVLIALRLRRWRSsallqsSGNLCSVPAPHFPGNDGTGTLPQSYSYEVCLTSDS----G 76


                   ....*
gi 1663450710 1520 KSDLM 1524
Cdd:pfam16492   77 KSEFK 81
Cadherin pfam00028
Cadherin domain;
2080-2127 1.69e-04

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 43.06  E-value: 1.69e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1663450710 2080 SVHSESGKLYALQSLDYEELKLLEFQVRAKDAGMPSLCGNATVQVFVL 2127
Cdd:pfam00028   45 RIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
1774-1821 2.60e-04

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 42.67  E-value: 2.60e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1663450710 1774 SVQSESGKLYALQSLDYEELKLLEFQVRAKDAGMPSLCGNATVQVFVL 1821
Cdd:pfam00028   45 RIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3113-3180 3.45e-04

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 41.95  E-value: 3.45e-04
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1663450710  3113 FQLVSKEQREYFQVNVQNGILFVNSQIDREKlydkraMCIVHLDALV----EKPLRIF-HIEVEIIDINDNAP 3180
Cdd:smart00112   15 YSILSGNDDGLFSIDPETGEITTTKPLDREE------QPEYTLTVEAtdggGPPLSSTaTVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2365-2420 2.38e-03

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 39.64  E-value: 2.38e-03
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1663450710  2365 EVNLQNGILFVNSRIDREELCaktadcVLHLEVIV----EKPLR-FFHVEVEVKDMNDNAP 2420
Cdd:smart00112   27 SIDPETGEITTTKPLDREEQP------EYTLTVEAtdggGPPLSsTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 8-59 5.26e-03

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 38.48  E-value: 5.26e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 1663450710     8 NNGILFVNSRIDREELCaktadcVLHLEVIV----EKPLR-FFHVEVEVKDMNDNAP 59
Cdd:smart00112   31 ETGEITTTKPLDREEQP------EYTLTVEAtdggGPPLSsTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 837-890 7.13e-03

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 38.10  E-value: 7.13e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 1663450710   837 EQINGILFVNSRIDREELCaktadcVLHLEVIV----EKPLR-FFHVEVEVKDMNDNAP 890
Cdd:smart00112   29 DPETGEITTTKPLDREEQP------EYTLTVEAtdggGPPLSsTATVTITVLDVNDNAP 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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