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Conserved domains on  [gi|1800033781|ref|XP_031991541|]
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toll-like receptor 1 [Hylobates moloch]

Protein Classification

toll-like receptor( domain architecture ID 11471523)

toll-like receptor (TLR) is involved in the recognition of microbial pathogens by the innate immune system, which recognize different pathogen-associated molecular patterns

CATH:  3.40.50.10140|3.80.10.10
Gene Ontology:  GO:0005515|GO:0002224|GO:0006955|GO:0004888|GO:0038187
PubMed:  18227810|16675322|34199501|16822173|11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
636-779 2.66e-41

Toll - interleukin 1 - resistance;


:

Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 147.47  E-value: 2.66e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800033781  636 QFHAFISYSGHDsfWVKNELLPNLEK--EGMQICLHERNFVPGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYF 713
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEklRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1800033781  714 AHHNLFHEGSNNLILILLEPIPQYsIPSSYHKLKSLMaRRTYLEWPKEKSKRglFWANLRAAINIK 779
Cdd:smart00255  79 ALENALEEGGLRVIPIFYEVIPSD-VRKQPGKFRKVF-KKNYLKWPEDEKEQ--FWKKALYAVPSK 140
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
353-526 7.27e-15

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 77.67  E-value: 7.27e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800033781 353 LDFSNNLLTDtVFENCGHLTELETLILQMNQLKELSkiaEMTTQMKSLQQLDISQNSVSY-DEKKGDCswtKSLLSLNMS 431
Cdd:COG4886   118 LDLSGNQLTD-LPEELANLTNLKELDLSNNQLTDLP---EPLGNLTNLKSLDLSNNQLTDlPEELGNL---TNLKELDLS 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800033781 432 SNVLTD---TIFRClpPRIKVLDLHSNKIKSIPKQVVKLEALQELNVAFNSLTDLPGCGSFSGLSVLIIDHNSVSHPSad 508
Cdd:COG4886   191 NNQITDlpePLGNL--TNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLP-- 266

                         170
                  ....*....|....*...
gi 1800033781 509 FFQSCQKMRSIKAGNNPF 526
Cdd:COG4886   267 PLANLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
29-152 1.47e-11

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 67.27  E-value: 1.47e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800033781  29 VDRSKNGLIYVPKDLSQKT--TILNISQNYISELqTSDILSLSKLRILIISHNRIQYLDMSVFKFNQeLEYLDLSHNKLA 106
Cdd:COG4886   118 LDLSGNQLTDLPEELANLTnlKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPEELGNLTN-LKELDLSNNQIT 195

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1800033781 107 KISCHPT--VNLKHLDLSFNAFDALPicKEFGNMSQLKFLGLSTTHLE 152
Cdd:COG4886   196 DLPEPLGnlTNLEELDLSGNQLTDLP--EPLANLTNLETLDLSNNQLT 241
LRRCT smart00082
Leucine rich repeat C-terminal domain;
524-577 8.69e-09

Leucine rich repeat C-terminal domain;


:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 52.05  E-value: 8.69e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1800033781  524 NPFQCTCELREFVKNIDQvssEVVEGWPDSYKCDYPESYRGtLLKDFHMSELSC 577
Cdd:smart00082   1 NPFICDCELRWLLRWLQA---NEHLQDPVDLRCASPSSLRG-PLLELLHSEFKC 50
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
636-779 2.66e-41

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 147.47  E-value: 2.66e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800033781  636 QFHAFISYSGHDsfWVKNELLPNLEK--EGMQICLHERNFVPGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYF 713
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEklRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1800033781  714 AHHNLFHEGSNNLILILLEPIPQYsIPSSYHKLKSLMaRRTYLEWPKEKSKRglFWANLRAAINIK 779
Cdd:smart00255  79 ALENALEEGGLRVIPIFYEVIPSD-VRKQPGKFRKVF-KKNYLKWPEDEKEQ--FWKKALYAVPSK 140
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 637-782 3.71e-25

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 102.44  E-value: 3.71e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800033781 637 FHAFISYSGHDSF-WVKNELLPNLEKEGMQICLHERNFVPGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYFAH 715
Cdd:pfam01582   1 YDVFLSFRGSDTReWFVSHLLKELKQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDELVKIL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800033781 716 HNLFhEGSNNLILILLEPIPQY------SIPSSYHKLKSLMARRTYLEWP------------KEKSKRGLFWANLRAAIN 777
Cdd:pfam01582  81 ECAL-DLGQKVIPIFYEVDPSDvrkqtgSFGKAFKKHKKVLTEEKVLKWRgalnevaniwhsKSVSDESKFWKKIAYDIS 159


                  ....*
gi 1800033781 778 IKLTG 782
Cdd:pfam01582 160 NKLNG 164
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
353-526 7.27e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 77.67  E-value: 7.27e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800033781 353 LDFSNNLLTDtVFENCGHLTELETLILQMNQLKELSkiaEMTTQMKSLQQLDISQNSVSY-DEKKGDCswtKSLLSLNMS 431
Cdd:COG4886   118 LDLSGNQLTD-LPEELANLTNLKELDLSNNQLTDLP---EPLGNLTNLKSLDLSNNQLTDlPEELGNL---TNLKELDLS 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800033781 432 SNVLTD---TIFRClpPRIKVLDLHSNKIKSIPKQVVKLEALQELNVAFNSLTDLPGCGSFSGLSVLIIDHNSVSHPSad 508
Cdd:COG4886   191 NNQITDlpePLGNL--TNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLP-- 266

                         170
                  ....*....|....*...
gi 1800033781 509 FFQSCQKMRSIKAGNNPF 526
Cdd:COG4886   267 PLANLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
29-152 1.47e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 67.27  E-value: 1.47e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800033781  29 VDRSKNGLIYVPKDLSQKT--TILNISQNYISELqTSDILSLSKLRILIISHNRIQYLDMSVFKFNQeLEYLDLSHNKLA 106
Cdd:COG4886   118 LDLSGNQLTDLPEELANLTnlKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPEELGNLTN-LKELDLSNNQIT 195

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1800033781 107 KISCHPT--VNLKHLDLSFNAFDALPicKEFGNMSQLKFLGLSTTHLE 152
Cdd:COG4886   196 DLPEPLGnlTNLEELDLSGNQLTDLP--EPLANLTNLETLDLSNNQLT 241
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 352-560 3.29e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 63.71  E-value: 3.29e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800033781 352 HLDFSNNLLTDTVFENCGHLTELETLILQMNQLKelSKIAEMTTQMKSLQQLDISQNSVSyDEKKGDCSWTKSLLSLNMS 431
Cdd:PLN00113  240 HLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLS--GPIPPSIFSLQKLISLDLSDNSLS-GEIPELVIQLQNLEILHLF 316

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800033781 432 SNVLTDTIFRCLP--PRIKVLDLHSNKIK-SIPKQVVKLEALQELNVAFNSLT-DLPGCGSFSG-LSVLIIDHNSVSHPS 506
Cdd:PLN00113  317 SNNFTGKIPVALTslPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTgEIPEGLCSSGnLFKLILFSNSLEGEI 396

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1800033781 507 ADFFQSCQKMRSIKAGNNPFqcTCEL-REFVK----NIDQVSSEVVEGWPDSYKCDYPE 560
Cdd:PLN00113  397 PKSLGACRSLRRVRLQDNSF--SGELpSEFTKlplvYFLDISNNNLQGRINSRKWDMPS 453
LRRCT smart00082
Leucine rich repeat C-terminal domain;
524-577 8.69e-09

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 52.05  E-value: 8.69e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1800033781  524 NPFQCTCELREFVKNIDQvssEVVEGWPDSYKCDYPESYRGtLLKDFHMSELSC 577
Cdd:smart00082   1 NPFICDCELRWLLRWLQA---NEHLQDPVDLRCASPSSLRG-PLLELLHSEFKC 50
LRR_8 pfam13855
Leucine rich repeat;
69-126 6.38e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.83  E-value: 6.38e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1800033781  69 SKLRILIISHNRIQYLDMSVFKFNQELEYLDLSHNKLAKIS---CHPTVNLKHLDLSFNAF 126
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSpgaFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 353-474 7.88e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 48.51  E-value: 7.88e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800033781 353 LDFSNNLLTD----TVFENCGHLTELETLILQMNQL--KELSKIAEMTTQMKSLQQLDISQNSVS----YDEKKGDCSWT 422
Cdd:cd00116   170 LNLANNGIGDagirALAEGLKANCNLEVLDLNNNGLtdEGASALAETLASLKSLEVLNLGDNNLTdagaAALASALLSPN 249

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1800033781 423 KSLLSLNMSSNVLTDTIFRCL------PPRIKVLDLHSNKIKSIPKQVVKLEALQELN 474
Cdd:cd00116   250 ISLLTLSLSCNDITDDGAKDLaevlaeKESLLELDLRGNKFGEEGAQLLAESLLEPGN 307
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
33-130 1.22e-04

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 45.46  E-value: 1.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800033781  33 KNGLIYVPKDLSQKTTILNISQNYISELQTSdilSLSKLRILIISHNRIQYLDMSVfkfNQELEYLDLSHNKLAKISCHP 112
Cdd:PRK15370  229 SNQLTSIPATLPDTIQEMELSINRITELPER---LPSALQSLDLFHNKISCLPENL---PEELRYLSVYDNSIRTLPAHL 302

                          90
                  ....*....|....*...
gi 1800033781 113 TVNLKHLDLSFNAFDALP 130
Cdd:PRK15370  303 PSGITHLNVQSNSLTALP 320
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 43-109 9.39e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 41.31  E-value: 9.39e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800033781  43 LSQKTTILNISQNYISELqtSDILSLSKLRILIISHNRIQYLD---MSVFKFNQeLEYLDLSHNKLAKIS 109
Cdd:cd21340   118 LSNSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEellDLLSSWPS-LRELDLTGNPVCKKP 184
LRR_8 pfam13855
Leucine rich repeat;
445-500 9.90e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.89  E-value: 9.90e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800033781 445 PRIKVLDLHSNKIKSIPKQV-VKLEALQELNVAFNSLTDLPGcGSFSGLS---VLIIDHN 500
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSP-GAFSGLPslrYLDLSGN 59
LRRCT pfam01463
Leucine rich repeat C-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 553-577 1.47e-03

Leucine rich repeat C-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the C-terminus of tandem leucine rich repeats.


Pssm-ID: 279765  Cd Length: 26  Bit Score: 36.65  E-value: 1.47e-03
                          10        20
                  ....*....|....*....|....*
gi 1800033781 553 SYKCDYPESYRGTLLKDFHMSELSC 577
Cdd:pfam01463   1 NARCASPPRLRGQPLLDLLPSDFSC 25
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
636-779 2.66e-41

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 147.47  E-value: 2.66e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800033781  636 QFHAFISYSGHDsfWVKNELLPNLEK--EGMQICLHERNFVPGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYF 713
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEklRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1800033781  714 AHHNLFHEGSNNLILILLEPIPQYsIPSSYHKLKSLMaRRTYLEWPKEKSKRglFWANLRAAINIK 779
Cdd:smart00255  79 ALENALEEGGLRVIPIFYEVIPSD-VRKQPGKFRKVF-KKNYLKWPEDEKEQ--FWKKALYAVPSK 140
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 637-782 3.71e-25

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 102.44  E-value: 3.71e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800033781 637 FHAFISYSGHDSF-WVKNELLPNLEKEGMQICLHERNFVPGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYFAH 715
Cdd:pfam01582   1 YDVFLSFRGSDTReWFVSHLLKELKQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDELVKIL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800033781 716 HNLFhEGSNNLILILLEPIPQY------SIPSSYHKLKSLMARRTYLEWP------------KEKSKRGLFWANLRAAIN 777
Cdd:pfam01582  81 ECAL-DLGQKVIPIFYEVDPSDvrkqtgSFGKAFKKHKKVLTEEKVLKWRgalnevaniwhsKSVSDESKFWKKIAYDIS 159


                  ....*
gi 1800033781 778 IKLTG 782
Cdd:pfam01582 160 NKLNG 164
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
 640-733 1.65e-16

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 76.20  E-value: 1.65e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800033781 640 FISYSGHDSFWVKnELLPNLEKEGMQICLHERNFVPGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHnlF 719
Cdd:pfam13676   2 FISYAGEDRAWAE-WLADALEAAGYRVWLDRWDIRPGDDWVEEIEEAIENSDRVLVVLSPNYLESPWCRAEWEAALA--D 78

                          90
                  ....*....|....
gi 1800033781 720 HEGSNNLILILLEP 733
Cdd:pfam13676  79 PEGRKRLIPVRLEC 92
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
353-526 7.27e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 77.67  E-value: 7.27e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800033781 353 LDFSNNLLTDtVFENCGHLTELETLILQMNQLKELSkiaEMTTQMKSLQQLDISQNSVSY-DEKKGDCswtKSLLSLNMS 431
Cdd:COG4886   118 LDLSGNQLTD-LPEELANLTNLKELDLSNNQLTDLP---EPLGNLTNLKSLDLSNNQLTDlPEELGNL---TNLKELDLS 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800033781 432 SNVLTD---TIFRClpPRIKVLDLHSNKIKSIPKQVVKLEALQELNVAFNSLTDLPGCGSFSGLSVLIIDHNSVSHPSad 508
Cdd:COG4886   191 NNQITDlpePLGNL--TNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLP-- 266

                         170
                  ....*....|....*...
gi 1800033781 509 FFQSCQKMRSIKAGNNPF 526
Cdd:COG4886   267 PLANLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
235-541 1.73e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 76.51  E-value: 1.73e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800033781 235 NILAKLQTNPKLSSLTLNNIETTWNSFIRILQLVWHTTVWYFSISNVKLQGRLDFRDFNYSGTSLKALSIHQVVSdVFNF 314
Cdd:COG4886    23 TLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTN-LTEL 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800033781 315 PQSDIYEIFSNMNIINFTVSGTRMVHMlcPSKISPFLHL---DFSNNLLTDtVFENCGHLTELETLILQMNQLKELSKIA 391
Cdd:COG4886   102 DLSGNEELSNLTNLESLDLSGNQLTDL--PEELANLTNLkelDLSNNQLTD-LPEPLGNLTNLKSLDLSNNQLTDLPEEL 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800033781 392 EmttQMKSLQQLDISQNSVSydEKKGDCSWTKSLLSLNMSSNVLTD---TIFRClpPRIKVLDLHSNKIKSIPkQVVKLE 468
Cdd:COG4886   179 G---NLTNLKELDLSNNQIT--DLPEPLGNLTNLEELDLSGNQLTDlpePLANL--TNLETLDLSNNQLTDLP-ELGNLT 250

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1800033781 469 ALQELNVAFNSLTDLPGCGSFSGLSVLIIDHNSVSHPSADFFQSCQKMRSIKAGNNPFQCTCELREFVKNIDQ 541
Cdd:COG4886   251 NLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTL 323
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
29-152 1.47e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 67.27  E-value: 1.47e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800033781  29 VDRSKNGLIYVPKDLSQKT--TILNISQNYISELqTSDILSLSKLRILIISHNRIQYLDMSVFKFNQeLEYLDLSHNKLA 106
Cdd:COG4886   118 LDLSGNQLTDLPEELANLTnlKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPEELGNLTN-LKELDLSNNQIT 195

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1800033781 107 KISCHPT--VNLKHLDLSFNAFDALPicKEFGNMSQLKFLGLSTTHLE 152
Cdd:COG4886   196 DLPEPLGnlTNLEELDLSGNQLTDLP--EPLANLTNLETLDLSNNQLT 241
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
32-272 4.74e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 65.73  E-value: 4.74e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800033781  32 SKNGLIYVPKDLSQ--KTTILNISQNYISELQTSdILSLSKLRILIISHNRIQYLDMSVFKFNQeLEYLDLSHNKLAKIs 109
Cdd:COG4886   167 SNNQLTDLPEELGNltNLKELDLSNNQITDLPEP-LGNLTNLEELDLSGNQLTDLPEPLANLTN-LETLDLSNNQLTDL- 243

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800033781 110 chPTV----NLKHLDLSFNAFDALPICKEFGNMSQLKFLGLSTTHLEKSSVLPIAHLNIGKVLLVLGETYGEKEDPEGLQ 185
Cdd:COG4886   244 --PELgnltNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLT 321

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800033781 186 DFNTESLHIVFPTNKEFHFILDVSVKTVANLELSNIKCVLEDNECSYFLNILAKLQTNPKLSSLTLNNIETTWNSFIRIL 265
Cdd:COG4886   322 TLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVL 401


                  ....*..
gi 1800033781 266 QLVWHTT 272
Cdd:COG4886   402 LLTLALL 408
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 352-560 3.29e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 63.71  E-value: 3.29e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800033781 352 HLDFSNNLLTDTVFENCGHLTELETLILQMNQLKelSKIAEMTTQMKSLQQLDISQNSVSyDEKKGDCSWTKSLLSLNMS 431
Cdd:PLN00113  240 HLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLS--GPIPPSIFSLQKLISLDLSDNSLS-GEIPELVIQLQNLEILHLF 316

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800033781 432 SNVLTDTIFRCLP--PRIKVLDLHSNKIK-SIPKQVVKLEALQELNVAFNSLT-DLPGCGSFSG-LSVLIIDHNSVSHPS 506
Cdd:PLN00113  317 SNNFTGKIPVALTslPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTgEIPEGLCSSGnLFKLILFSNSLEGEI 396

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1800033781 507 ADFFQSCQKMRSIKAGNNPFqcTCEL-REFVK----NIDQVSSEVVEGWPDSYKCDYPE 560
Cdd:PLN00113  397 PKSLGACRSLRRVRLQDNSF--SGELpSEFTKlplvYFLDISNNNLQGRINSRKWDMPS 453
LRRCT smart00082
Leucine rich repeat C-terminal domain;
524-577 8.69e-09

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 52.05  E-value: 8.69e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1800033781  524 NPFQCTCELREFVKNIDQvssEVVEGWPDSYKCDYPESYRGtLLKDFHMSELSC 577
Cdd:smart00082   1 NPFICDCELRWLLRWLQA---NEHLQDPVDLRCASPSSLRG-PLLELLHSEFKC 50
LRR_8 pfam13855
Leucine rich repeat;
69-126 6.38e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.83  E-value: 6.38e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1800033781  69 SKLRILIISHNRIQYLDMSVFKFNQELEYLDLSHNKLAKIS---CHPTVNLKHLDLSFNAF 126
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSpgaFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
48-105 8.73e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.75  E-value: 8.73e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1800033781  48 TILNISQNYISELQTSDILSLSKLRILIISHNRIQYLDMSVFKFNQELEYLDLSHNKL 105
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 353-474 7.88e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 48.51  E-value: 7.88e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800033781 353 LDFSNNLLTD----TVFENCGHLTELETLILQMNQL--KELSKIAEMTTQMKSLQQLDISQNSVS----YDEKKGDCSWT 422
Cdd:cd00116   170 LNLANNGIGDagirALAEGLKANCNLEVLDLNNNGLtdEGASALAETLASLKSLEVLNLGDNNLTdagaAALASALLSPN 249

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1800033781 423 KSLLSLNMSSNVLTDTIFRCL------PPRIKVLDLHSNKIKSIPKQVVKLEALQELN 474
Cdd:cd00116   250 ISLLTLSLSCNDITDDGAKDLaevlaeKESLLELDLRGNKFGEEGAQLLAESLLEPGN 307
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
2-152 9.28e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 48.78  E-value: 9.28e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800033781   2 TGIFPFAIIFMLILQIRIQLSEESEFLVDRSKNGLIYVPKDLSQKTTILNISQNYISELQTSDILSLSKLRILIISHNRI 81
Cdd:COG4886    29 LLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEE 108

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1800033781  82 qyldmsvFKFNQELEYLDLSHNKLAKISCHPT--VNLKHLDLSFNAFDALPicKEFGNMSQLKFLGLSTTHLE 152
Cdd:COG4886   109 -------LSNLTNLESLDLSGNQLTDLPEELAnlTNLKELDLSNNQLTDLP--EPLGNLTNLKSLDLSNNQLT 172
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
316-484 7.44e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 46.23  E-value: 7.44e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800033781 316 QSDIYEIFSNMNIInftvsgTRMVHMLcPSKISpflHLDFSNNLLTdtvfENCGHL-TELETLILQMNQLKELSKiaemt 394
Cdd:PRK15370  219 QGNIKTLYANSNQL------TSIPATL-PDTIQ---EMELSINRIT----ELPERLpSALQSLDLFHNKISCLPE----- 279

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800033781 395 TQMKSLQQLDISQNSVSYDEKKgdcsWTKSLLSLNMSSNVLT----------------DTIFRCLP----PRIKVLDLHS 454
Cdd:PRK15370  280 NLPEELRYLSVYDNSIRTLPAH----LPSGITHLNVQSNSLTalpetlppglktleagENALTSLPaslpPELQVLDVSK 355

                         170       180       190
                  ....*....|....*....|....*....|
gi 1800033781 455 NKIKSIPKQVVKleALQELNVAFNSLTDLP 484
Cdd:PRK15370  356 NQITVLPETLPP--TITTLDVSRNALTNLP 383
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
33-130 1.22e-04

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 45.46  E-value: 1.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800033781  33 KNGLIYVPKDLSQKTTILNISQNYISELQTSdilSLSKLRILIISHNRIQYLDMSVfkfNQELEYLDLSHNKLAKISCHP 112
Cdd:PRK15370  229 SNQLTSIPATLPDTIQEMELSINRITELPER---LPSALQSLDLFHNKISCLPENL---PEELRYLSVYDNSIRTLPAHL 302

                          90
                  ....*....|....*...
gi 1800033781 113 TVNLKHLDLSFNAFDALP 130
Cdd:PRK15370  303 PSGITHLNVQSNSLTALP 320
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 273-435 3.46e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.07  E-value: 3.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800033781 273 VWYFSISNVKLQGRLDFRDFNYsgTSLKALSIhqVVSDVF-NFPQSdiyeiFSNMNIINFTVSGTRMVHMLcPSK---IS 348
Cdd:PLN00113  430 VYFLDISNNNLQGRINSRKWDM--PSLQMLSL--ARNKFFgGLPDS-----FGSKRLENLDLSRNQFSGAV-PRKlgsLS 499

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800033781 349 PFLHLDFSNNLLTDTVFENCGHLTELETLILQMNQLKelSKIAEMTTQMKSLQQLDISQNSVSYDEKKgDCSWTKSLLSL 428
Cdd:PLN00113  500 ELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLS--GQIPASFSEMPVLSQLDLSQNQLSGEIPK-NLGNVESLVQV 576


                  ....*..
gi 1800033781 429 NMSSNVL 435
Cdd:PLN00113  577 NISHNHL 583
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 43-109 9.39e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 41.31  E-value: 9.39e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800033781  43 LSQKTTILNISQNYISELqtSDILSLSKLRILIISHNRIQYLD---MSVFKFNQeLEYLDLSHNKLAKIS 109
Cdd:cd21340   118 LSNSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEellDLLSSWPS-LRELDLTGNPVCKKP 184
LRR_8 pfam13855
Leucine rich repeat;
445-500 9.90e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.89  E-value: 9.90e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800033781 445 PRIKVLDLHSNKIKSIPKQV-VKLEALQELNVAFNSLTDLPGcGSFSGLS---VLIIDHN 500
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSP-GAFSGLPslrYLDLSGN 59
LRRCT pfam01463
Leucine rich repeat C-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 553-577 1.47e-03

Leucine rich repeat C-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the C-terminus of tandem leucine rich repeats.


Pssm-ID: 279765  Cd Length: 26  Bit Score: 36.65  E-value: 1.47e-03
                          10        20
                  ....*....|....*....|....*
gi 1800033781 553 SYKCDYPESYRGTLLKDFHMSELSC 577
Cdd:pfam01463   1 NARCASPPRLRGQPLLDLLPSDFSC 25
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 352-411 2.68e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.15  E-value: 2.68e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800033781 352 HLDFSNNLLTDTvfENCGHLTELETLILQMNQLKELSKIAEMTTQMKSLQQLDISQNSVS 411
Cdd:cd21340   124 VLNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEELLDLLSSWPSLRELDLTGNPVC 181
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 48-147 5.85e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.00  E-value: 5.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800033781  48 TILNISQNYISELQtsDILSLSKLRILIISHNRIQ--------------YLD--------------MSVFKFNQELEYLD 99
Cdd:cd21340    49 THLYLQNNQIEKIE--NLENLVNLKKLYLGGNRISvveglenltnleelHIEnqrlppgekltfdpRSLAALSNSLRVLN 126

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1800033781 100 LSHNKLAKISC-HPTVNLKHLDLSFNAFDAL-PICKEFGNMSQLKFLGLS 147
Cdd:cd21340   127 ISGNNIDSLEPlAPLRNLEQLDASNNQISDLeELLDLLSSWPSLRELDLT 176
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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