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Conserved domains on  [gi|1843748080|ref|XP_034466032|]
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Krueppel-like factor 10 isoform X2 [Hippoglossus hippoglossus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KLF10_N cd21572
N-terminal domain of Kruppel-like factor 10; Kruppel-like factor 10 (KLF10; also known as ...
 1-254 1.07e-71

N-terminal domain of Kruppel-like factor 10; Kruppel-like factor 10 (KLF10; also known as Krueppel-like factor 10; early growth response(EGR)-alpha/EGRA; TGFbeta inducible early gene-1/TIEG1) is a protein that in humans is encoded by the KLF10 gene. KLF10 was first identified in human osteoblasts and plays a role in mediating estrogen (E2) signaling in bone and skeletal homeostasis and a regulatory role in tumor formation and metastasis. It may also play a role in adipocyte differentiation and adipose tissue function. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved a-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF10 belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF10.


:

Pssm-ID: 409241 [Multi-domain]  Cd Length: 245  Bit Score: 223.71  E-value: 1.07e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843748080   1 MTPPYSPPHCEATHLPS----ERLTWQPAEGANLVAHTAASQQRFQCTSVIRHTADGQHCCCSIHPDrltevhtkdfkrd 76
Cdd:cd21572    58 MTPPYSPPHFEATHPPSaatlHPPAAQPPEEQHLSAETAASQQRFQCTSVIRHTADAQPCSCSSCPS------------- 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843748080  77 lnfedglntrdsekiivmqsdSPQKPLTVtypevgkenktqrslsgpddkSIIPQRVSPVPVYSQILPVSSLSTTVVQkp 156
Cdd:cd21572   125 ---------------------SPSVVPSV---------------------PAGVAGVSPVPVYCQILPVSSSSTTVVA-- 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843748080 157 itafesqmqhqlltEQHTLQKPKHHTASSAQAFILGGQVAQGPLMLLVPQLVISALYIQPALVTPGGNKLPAIAPAPRRT 236
Cdd:cd21572   161 --------------AQAPLPQPQQQAASPAQVFLMGGQVPKGPVMFLVPQPVVPTLYVQPTLVTPGGTKLAAIAPAPGHT 226

                         250
                  ....*....|....*...
gi 1843748080 237 LLQQRQNPLQPEVSRVRS 254
Cdd:cd21572   227 PSEQRKSPPQPEVSRVRS 244
zf-H2C2_2 pfam13465
Zinc-finger double domain;
271-298 1.93e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 1.93e-04
                          10        20
                  ....*....|....*....|....*...
gi 1843748080 271 HLKAHMRTHTGEKPFKCKwqGCERRFAR 298
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCP--ECGKSFKS 26
 
Name Accession Description Interval E-value
KLF10_N cd21572
N-terminal domain of Kruppel-like factor 10; Kruppel-like factor 10 (KLF10; also known as ...
 1-254 1.07e-71

N-terminal domain of Kruppel-like factor 10; Kruppel-like factor 10 (KLF10; also known as Krueppel-like factor 10; early growth response(EGR)-alpha/EGRA; TGFbeta inducible early gene-1/TIEG1) is a protein that in humans is encoded by the KLF10 gene. KLF10 was first identified in human osteoblasts and plays a role in mediating estrogen (E2) signaling in bone and skeletal homeostasis and a regulatory role in tumor formation and metastasis. It may also play a role in adipocyte differentiation and adipose tissue function. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved a-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF10 belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF10.


Pssm-ID: 409241 [Multi-domain]  Cd Length: 245  Bit Score: 223.71  E-value: 1.07e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843748080   1 MTPPYSPPHCEATHLPS----ERLTWQPAEGANLVAHTAASQQRFQCTSVIRHTADGQHCCCSIHPDrltevhtkdfkrd 76
Cdd:cd21572    58 MTPPYSPPHFEATHPPSaatlHPPAAQPPEEQHLSAETAASQQRFQCTSVIRHTADAQPCSCSSCPS------------- 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843748080  77 lnfedglntrdsekiivmqsdSPQKPLTVtypevgkenktqrslsgpddkSIIPQRVSPVPVYSQILPVSSLSTTVVQkp 156
Cdd:cd21572   125 ---------------------SPSVVPSV---------------------PAGVAGVSPVPVYCQILPVSSSSTTVVA-- 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843748080 157 itafesqmqhqlltEQHTLQKPKHHTASSAQAFILGGQVAQGPLMLLVPQLVISALYIQPALVTPGGNKLPAIAPAPRRT 236
Cdd:cd21572   161 --------------AQAPLPQPQQQAASPAQVFLMGGQVPKGPVMFLVPQPVVPTLYVQPTLVTPGGTKLAAIAPAPGHT 226

                         250
                  ....*....|....*...
gi 1843748080 237 LLQQRQNPLQPEVSRVRS 254
Cdd:cd21572   227 PSEQRKSPPQPEVSRVRS 244
zf-H2C2_2 pfam13465
Zinc-finger double domain;
271-298 1.93e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 1.93e-04
                          10        20
                  ....*....|....*....|....*...
gi 1843748080 271 HLKAHMRTHTGEKPFKCKwqGCERRFAR 298
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCP--ECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
239-311 6.22e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 6.22e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1843748080 239 QQRQNPLQPEVSRVRSYACSHEDCSKTYFKSSHLKAHMRT--HTGE--KPFKCKWQGCERRFARSDELSRHRHTHTG 311
Cdd:COG5048   272 SSSPNESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTS 348
 
Name Accession Description Interval E-value
KLF10_N cd21572
N-terminal domain of Kruppel-like factor 10; Kruppel-like factor 10 (KLF10; also known as ...
 1-254 1.07e-71

N-terminal domain of Kruppel-like factor 10; Kruppel-like factor 10 (KLF10; also known as Krueppel-like factor 10; early growth response(EGR)-alpha/EGRA; TGFbeta inducible early gene-1/TIEG1) is a protein that in humans is encoded by the KLF10 gene. KLF10 was first identified in human osteoblasts and plays a role in mediating estrogen (E2) signaling in bone and skeletal homeostasis and a regulatory role in tumor formation and metastasis. It may also play a role in adipocyte differentiation and adipose tissue function. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved a-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF10 belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF10.


Pssm-ID: 409241 [Multi-domain]  Cd Length: 245  Bit Score: 223.71  E-value: 1.07e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843748080   1 MTPPYSPPHCEATHLPS----ERLTWQPAEGANLVAHTAASQQRFQCTSVIRHTADGQHCCCSIHPDrltevhtkdfkrd 76
Cdd:cd21572    58 MTPPYSPPHFEATHPPSaatlHPPAAQPPEEQHLSAETAASQQRFQCTSVIRHTADAQPCSCSSCPS------------- 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843748080  77 lnfedglntrdsekiivmqsdSPQKPLTVtypevgkenktqrslsgpddkSIIPQRVSPVPVYSQILPVSSLSTTVVQkp 156
Cdd:cd21572   125 ---------------------SPSVVPSV---------------------PAGVAGVSPVPVYCQILPVSSSSTTVVA-- 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843748080 157 itafesqmqhqlltEQHTLQKPKHHTASSAQAFILGGQVAQGPLMLLVPQLVISALYIQPALVTPGGNKLPAIAPAPRRT 236
Cdd:cd21572   161 --------------AQAPLPQPQQQAASPAQVFLMGGQVPKGPVMFLVPQPVVPTLYVQPTLVTPGGTKLAAIAPAPGHT 226

                         250
                  ....*....|....*...
gi 1843748080 237 LLQQRQNPLQPEVSRVRS 254
Cdd:cd21572   227 PSEQRKSPPQPEVSRVRS 244
KLF10_11_N cd21974
N-terminal domain of Kruppel-like factor (KLF) 10, KLF11, and similar proteins; This subfamily ...
 1-255 1.41e-53

N-terminal domain of Kruppel-like factor (KLF) 10, KLF11, and similar proteins; This subfamily is composed of Kruppel-like factor or Krueppel-like factor (KLF) 10, KLF11, and similar proteins. KLF10 was first identified in human osteoblasts and plays a role in mediating estrogen (E2) signaling in bone and skeletal homeostasis and a regulatory role in tumor formation and metastasis. KLF11 is involved in cell growth, apoptosis, cellular inflammation and differentiation, endometriosis, and cholesterol, prostaglandin, neurotransmitter, fat, and sugar metabolism. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved a-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF10/11 belong to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF10, KLF11, and similar proteins.


Pssm-ID: 409243 [Multi-domain]  Cd Length: 229  Bit Score: 176.28  E-value: 1.41e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843748080   1 MTPPYSPPHCEATHLPS-------ERLTWQPAEGANLVAHTAASQQRFQCTSVIRHTADgqhcccsihpdrltevhtkdf 73
Cdd:cd21974    58 MTPPYSPPFFEASHSPSvaslhppSAASSQPPPEPESSEPPAASPQRAQATSVIRHTAD--------------------- 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843748080  74 krdlnfedglntrdsekiivmqsdspqkpltvtypevgkenktqrslsgpddksiiPQRVSPVPVYSQILPVSSLSTTVV 153
Cdd:cd21974   117 --------------------------------------------------------PVPVSPPPVLCQMLPVSSSSGVIV 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843748080 154 QKPITAfesqmqhqllteQHTLQKPKHHTASSAQAFILGGQVAQGPLMLLVPQLVISALYIQPALVTPGGNKLPAIAPAP 233
Cdd:cd21974   141 AFLKAP------------QQPSPQPQKPALPQPQVVLVGGQVPQGPVMLVVPQPAVPQPYVQPTVVTPGGTKLLPIAPAP 208

                         250       260
                  ....*....|....*....|..
gi 1843748080 234 RRTLLQQRqNPLQPEVSRVRSY 255
Cdd:cd21974   209 GFIPSGQS-SAPQPDFSRRRNH 229
KLF11_N cd21584
N-terminal domain of Kruppel-like factor 11; Kruppel-like factor 11 (KLF11; also known as ...
 130-233 1.20e-07

N-terminal domain of Kruppel-like factor 11; Kruppel-like factor 11 (KLF11; also known as Krueppel-like factor 11; Fetal Kruppel-like factor-1/FKLF-1; maturity-onset diabetes of the young 7/MODY7; TGFbeta Inducible Early Growth Response 2/TIEG2) is a protein that in humans is encoded by the KLF11 gene. KLF11 is involved in cell growth, apoptosis, cellular inflammation and differentiation, endometriosis, and cholesterol, prostaglandin, neurotransmitter, fat, and sugar metabolism. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved a-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF11 belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF11.


Pssm-ID: 409242 [Multi-domain]  Cd Length: 217  Bit Score: 51.92  E-value: 1.20e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843748080 130 PQRVSPVPVYSQILPVSSLSTTvvqkpITAFEsqmqhQLLTEQHTLQKPK-HHTASSAQAFILGGQVAQGPLMLLVPQ-L 207
Cdd:cd21584   101 PVPVPSPPVLCQMIPVSGQSGM-----ISAFL-----QPPALSAGTVKPIlPQTAPASQPLLVGSPVPQGTVMLVLPQaS 170

                          90       100
                  ....*....|....*....|....*.
gi 1843748080 208 VISALYIQPALVTPGGNKLPAIAPAP 233
Cdd:cd21584   171 VPQPPQCPQTVMTLGNTKLLPLAPAP 196
zf-H2C2_2 pfam13465
Zinc-finger double domain;
271-298 1.93e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 1.93e-04
                          10        20
                  ....*....|....*....|....*...
gi 1843748080 271 HLKAHMRTHTGEKPFKCKwqGCERRFAR 298
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCP--ECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
239-311 6.22e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 6.22e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1843748080 239 QQRQNPLQPEVSRVRSYACSHEDCSKTYFKSSHLKAHMRT--HTGE--KPFKCKWQGCERRFARSDELSRHRHTHTG 311
Cdd:COG5048   272 SSSPNESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTS 348
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
237-322 1.29e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.45  E-value: 1.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843748080 237 LLQQRQNPLQPEVSRVRSYACshEDCSKTYFKSSHLKAHMRTHTGEKPFKCKWQGCERRFARSDELSRHRHTHTGEKKFV 316
Cdd:COG5048    16 LSSTPKSTLKSLSNAPRPDSC--PNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDL 93


                  ....*.
gi 1843748080 317 CPMCLN 322
Cdd:COG5048    94 NSKSLP 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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