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Conserved domains on  [gi|1868077986|ref|XP_035317422|]
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amphoterin-induced protein 1 [Cricetulus griseus]

Protein Classification

LRR and IG_like domain-containing protein( domain architecture ID 11471650)

LRR and IG_like domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
44-224 2.74e-25

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 107.71  E-value: 2.74e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868077986  44 ILSCSKQQLPSVPQSLPSYTAL--LDLSHNNLSRLRAEWTptRLINLHSLLLSHNHLNFISSEaFVPVPNLRYLDLSSNH 121
Cdd:COG4886   117 SLDLSGNQLTDLPEELANLTNLkeLDLSNNQLTDLPEPLG--NLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQ 193

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868077986 122 LHTLDEFLfSDLHALEVLLLYNNRIMAVDRyAFEDMAQLQKLYLSQNQISRFPlELikdgNKLPKLMLLDLSSNKLKKLP 201
Cdd:COG4886   194 ITDLPEPL-GNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLP-EL----GNLTNLEELDLSNNQLTDLP 266

                         170       180
                  ....*....|....*....|....
gi 1868077986 202 FT-DLQKLpawvkNGLYLHNNPLE 224
Cdd:COG4886   267 PLaNLTNL-----KTLDLSNNQLT 285
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 279-358 1.12e-08

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


:

Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 52.12  E-value: 1.12e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868077986  279 EAHLGDTLTITCDTKQQGMTKVWVTPSNEQVLNQGANGTVTVSE-DGSLRFEKVQVEDGGVYTCYAMGETFNETLSVELK 357
Cdd:smart00410   5 TVKEGESVTLSCEASGSPPPEVTWYKQGGKLLAESGRFSVSRSGsTSTLTISNVTPEDSGTYTCAATNSSGSASSGTTLT 84


                   .
gi 1868077986  358 V 358
Cdd:smart00410  85 V 85
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
44-224 2.74e-25

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 107.71  E-value: 2.74e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868077986  44 ILSCSKQQLPSVPQSLPSYTAL--LDLSHNNLSRLRAEWTptRLINLHSLLLSHNHLNFISSEaFVPVPNLRYLDLSSNH 121
Cdd:COG4886   117 SLDLSGNQLTDLPEELANLTNLkeLDLSNNQLTDLPEPLG--NLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQ 193

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868077986 122 LHTLDEFLfSDLHALEVLLLYNNRIMAVDRyAFEDMAQLQKLYLSQNQISRFPlELikdgNKLPKLMLLDLSSNKLKKLP 201
Cdd:COG4886   194 ITDLPEPL-GNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLP-EL----GNLTNLEELDLSNNQLTDLP 266

                         170       180
                  ....*....|....*....|....
gi 1868077986 202 FT-DLQKLpawvkNGLYLHNNPLE 224
Cdd:COG4886   267 PLaNLTNL-----KTLDLSNNQLT 285
LRR_8 pfam13855
Leucine rich repeat;
110-170 2.82e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 64.47  E-value: 2.82e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1868077986 110 PNLRYLDLSSNHLHTLDEFLFSDLHALEVLLLYNNRIMAVDRYAFEDMAQLQKLYLSQNQI 170
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
30-213 1.22e-12

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 70.50  E-value: 1.22e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868077986  30 SVVSCPANCLCASNILSCSKQQLPSVPQSLPSYTALLDLSHNNLSRLraewtPTRLIN-LHSLLLSHNHLNFISSEafvp 108
Cdd:PRK15370  210 ELKSLPENLQGNIKTLYANSNQLTSIPATLPDTIQEMELSINRITEL-----PERLPSaLQSLDLFHNKISCLPEN---- 280

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868077986 109 VPN-LRYLDLSSNHLHTLDE---------FLFSD-LHALEVLLLYNNRIMAVDRYAFEDM-----AQLQKLYLSQNQISR 172
Cdd:PRK15370  281 LPEeLRYLSVYDNSIRTLPAhlpsgithlNVQSNsLTALPETLPPGLKTLEAGENALTSLpaslpPELQVLDVSKNQITV 360

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1868077986 173 FPLELIkdgnklPKLMLLDLSSNKLKKLPftdlQKLPAWVK 213
Cdd:PRK15370  361 LPETLP------PTITTLDVSRNALTNLP----ENLPAALQ 391
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 279-358 1.12e-08

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 52.12  E-value: 1.12e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868077986  279 EAHLGDTLTITCDTKQQGMTKVWVTPSNEQVLNQGANGTVTVSE-DGSLRFEKVQVEDGGVYTCYAMGETFNETLSVELK 357
Cdd:smart00410   5 TVKEGESVTLSCEASGSPPPEVTWYKQGGKLLAESGRFSVSRSGsTSTLTISNVTPEDSGTYTCAATNSSGSASSGTTLT 84


                   .
gi 1868077986  358 V 358
Cdd:smart00410  85 V 85
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 93-238 8.49e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 49.78  E-value: 8.49e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868077986  93 LSHNHLN--FISS-EAFVPVPNLRYLDLSSNHLHTLDEFLFsdLHALEVLLLYNNRIMAVDRyaFEDMAQLQKLYLSQNQ 169
Cdd:cd21340     4 ITHLYLNdkNITKiDNLSLCKNLKVLYLYDNKITKIENLEF--LTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868077986 170 ISRfpLE-----------------------LIKDGNKL----PKLMLLDLSSNKLKKLpfTDLQKLPAWVKngLYLHNNP 222
Cdd:cd21340    80 ISV--VEglenltnleelhienqrlppgekLTFDPRSLaalsNSLRVLNISGNNIDSL--EPLAPLRNLEQ--LDASNNQ 153

                         170
                  ....*....|....*.
gi 1868077986 223 LECDCKLYQLFSHWQY 238
Cdd:cd21340   154 ISDLEELLDLLSSWPS 169
I-set pfam07679
Immunoglobulin I-set domain;
279-358 1.83e-06

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 46.10  E-value: 1.83e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868077986 279 EAHLGDTLTITCDTKQQGMTKV-WVtpSNEQVLNQGANGTVTVSED-GSLRFEKVQVEDGGVYTCYAMGETFNETLSVEL 356
Cdd:pfam07679  11 EVQEGESARFTCTVTGTPDPEVsWF--KDGQPLRSSDRFKVTYEGGtYTLTISNVQPDDSGKYTCVATNSAGEAEASAEL 88


                  ..
gi 1868077986 357 KV 358
Cdd:pfam07679  89 TV 90
IgI_Lingo-1 cd20969
Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing ...
 283-358 7.08e-05

Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1); The members here are composed of the immunoglobulin I-set (IgI) domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1). Human Lingo-1 is a central nervous system-specific transmembrane glycoprotein also known as LERN-1, which functions as a negative regulator of neuronal survival, axonal regeneration, and oligodendrocyte differentiation and myelination. Lingo-1 is a key component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. The ligand-binding ectodomain of human Lingo-1 contains a bimodular, kinked structure composed of leucine-rich repeat (LRR) and immunoglobulin (Ig)-like modules. Diseases associated with Lingo-1 include mental retardation, autosomal recessive 64 and essential tremor. The Ig superfamily (IgSF) is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Unlike the V-set, one of the distinctive features of I-set domains is the lack of a C" strand. The structure of the Lingo-1 lacks this strand and thus it belongs to the I-set of the IgSF. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors, the hemolymph protein hemolin, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, and the signaling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis.


Pssm-ID: 409561  Cd Length: 92  Bit Score: 41.61  E-value: 7.08e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1868077986 283 GDTLTITCdtKQQGM---TKVWVTPsNEQVLNQGANGTVTVSEDGSLRFEKVQVEDGGVYTCYAMGETFNETLSVELKV 358
Cdd:cd20969    17 GHTVQFVC--RADGDpppAILWLSP-RKHLVSAKSNGRLTVFPDGTLEVRYAQVQDNGTYLCIAANAGGNDSMPAHLHV 92
LRRNT smart00013
Leucine rich repeat N-terminal domain;
34-63 3.44e-03

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 34.99  E-value: 3.44e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1868077986   34 CPANCLCASNILSCSKQQLPSVPQSLPSYT 63
Cdd:smart00013   2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDT 31
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
44-224 2.74e-25

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 107.71  E-value: 2.74e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868077986  44 ILSCSKQQLPSVPQSLPSYTAL--LDLSHNNLSRLRAEWTptRLINLHSLLLSHNHLNFISSEaFVPVPNLRYLDLSSNH 121
Cdd:COG4886   117 SLDLSGNQLTDLPEELANLTNLkeLDLSNNQLTDLPEPLG--NLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQ 193

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868077986 122 LHTLDEFLfSDLHALEVLLLYNNRIMAVDRyAFEDMAQLQKLYLSQNQISRFPlELikdgNKLPKLMLLDLSSNKLKKLP 201
Cdd:COG4886   194 ITDLPEPL-GNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLP-EL----GNLTNLEELDLSNNQLTDLP 266

                         170       180
                  ....*....|....*....|....
gi 1868077986 202 FT-DLQKLpawvkNGLYLHNNPLE 224
Cdd:COG4886   267 PLaNLTNL-----KTLDLSNNQLT 285
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
44-235 1.51e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 102.70  E-value: 1.51e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868077986  44 ILSCSKQQLPSVPQSLPSYTAL--LDLSHNNLSRLRAEWTPtrLINLHSLLLSHNHLNFISsEAFVPVPNLRYLDLSSNH 121
Cdd:COG4886   140 ELDLSNNQLTDLPEPLGNLTNLksLDLSNNQLTDLPEELGN--LTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQ 216

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868077986 122 LHTLDEFLfSDLHALEVLLLYNNRImaVDRYAFEDMAQLQKLYLSQNQISRFPLELikdgnKLPKLMLLDLSSNKLKKLP 201
Cdd:COG4886   217 LTDLPEPL-ANLTNLETLDLSNNQL--TDLPELGNLTNLEELDLSNNQLTDLPPLA-----NLTNLKTLDLSNNQLTDLK 288

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1868077986 202 FTDLQKLPAWVKNGLYLHNNPLECDCKLYQLFSH 235
Cdd:COG4886   289 LKELELLLGLNSLLLLLLLLNLLELLILLLLLTT 322
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
43-224 2.98e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 92.69  E-value: 2.98e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868077986  43 NILSCSKQQLPSVPQSLPSYTALLDLSHNNLSRLRAEWTPTRLINLHSLLLSHNHLNFIsSEAFVPVPNLRYLDLSSNHL 122
Cdd:COG4886    70 SLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQL 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868077986 123 HTLDEFLfSDLHALEVLLLYNNRIMAVDRyAFEDMAQLQKLYLSQNQISRFPLELikdgNKLPKLMLLDLSSNKLKKLP- 201
Cdd:COG4886   149 TDLPEPL-GNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLPEPL----GNLTNLEELDLSGNQLTDLPe 222

                         170       180
                  ....*....|....*....|....
gi 1868077986 202 -FTDLQKLpawvkNGLYLHNNPLE 224
Cdd:COG4886   223 pLANLTNL-----ETLDLSNNQLT 241
LRR_8 pfam13855
Leucine rich repeat;
110-170 2.82e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 64.47  E-value: 2.82e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1868077986 110 PNLRYLDLSSNHLHTLDEFLFSDLHALEVLLLYNNRIMAVDRYAFEDMAQLQKLYLSQNQI 170
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
87-146 7.06e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 63.31  E-value: 7.06e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868077986  87 NLHSLLLSHNHLNFISSEAFVPVPNLRYLDLSSNHLHTLDEFLFSDLHALEVLLLYNNRI 146
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
30-213 1.22e-12

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 70.50  E-value: 1.22e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868077986  30 SVVSCPANCLCASNILSCSKQQLPSVPQSLPSYTALLDLSHNNLSRLraewtPTRLIN-LHSLLLSHNHLNFISSEafvp 108
Cdd:PRK15370  210 ELKSLPENLQGNIKTLYANSNQLTSIPATLPDTIQEMELSINRITEL-----PERLPSaLQSLDLFHNKISCLPEN---- 280

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868077986 109 VPN-LRYLDLSSNHLHTLDE---------FLFSD-LHALEVLLLYNNRIMAVDRYAFEDM-----AQLQKLYLSQNQISR 172
Cdd:PRK15370  281 LPEeLRYLSVYDNSIRTLPAhlpsgithlNVQSNsLTALPETLPPGLKTLEAGENALTSLpaslpPELQVLDVSKNQITV 360

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1868077986 173 FPLELIkdgnklPKLMLLDLSSNKLKKLPftdlQKLPAWVK 213
Cdd:PRK15370  361 LPETLP------PTITTLDVSRNALTNLP----ENLPAALQ 391
LRR_8 pfam13855
Leucine rich repeat;
66-122 1.88e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.08  E-value: 1.88e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1868077986  66 LDLSHNNLSRLRAEWtPTRLINLHSLLLSHNHLNFISSEAFVPVPNLRYLDLSSNHL 122
Cdd:pfam13855   6 LDLSNNRLTSLDDGA-FKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 279-358 1.12e-08

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 52.12  E-value: 1.12e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868077986  279 EAHLGDTLTITCDTKQQGMTKVWVTPSNEQVLNQGANGTVTVSE-DGSLRFEKVQVEDGGVYTCYAMGETFNETLSVELK 357
Cdd:smart00410   5 TVKEGESVTLSCEASGSPPPEVTWYKQGGKLLAESGRFSVSRSGsTSTLTISNVTPEDSGTYTCAATNSSGSASSGTTLT 84


                   .
gi 1868077986  358 V 358
Cdd:smart00410  85 V 85
LRR_8 pfam13855
Leucine rich repeat;
136-197 4.03e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.83  E-value: 4.03e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1868077986 136 LEVLLLYNNRIMAVDRYAFEDMAQLQKLYLSQNQISRFPLELIKDgnkLPKLMLLDLSSNKL 197
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSG---LPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 93-238 8.49e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 49.78  E-value: 8.49e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868077986  93 LSHNHLN--FISS-EAFVPVPNLRYLDLSSNHLHTLDEFLFsdLHALEVLLLYNNRIMAVDRyaFEDMAQLQKLYLSQNQ 169
Cdd:cd21340     4 ITHLYLNdkNITKiDNLSLCKNLKVLYLYDNKITKIENLEF--LTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868077986 170 ISRfpLE-----------------------LIKDGNKL----PKLMLLDLSSNKLKKLpfTDLQKLPAWVKngLYLHNNP 222
Cdd:cd21340    80 ISV--VEglenltnleelhienqrlppgekLTFDPRSLaalsNSLRVLNISGNNIDSL--EPLAPLRNLEQ--LDASNNQ 153

                         170
                  ....*....|....*.
gi 1868077986 223 LECDCKLYQLFSHWQY 238
Cdd:cd21340   154 ISDLEELLDLLSSWPS 169
I-set pfam07679
Immunoglobulin I-set domain;
279-358 1.83e-06

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 46.10  E-value: 1.83e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868077986 279 EAHLGDTLTITCDTKQQGMTKV-WVtpSNEQVLNQGANGTVTVSED-GSLRFEKVQVEDGGVYTCYAMGETFNETLSVEL 356
Cdd:pfam07679  11 EVQEGESARFTCTVTGTPDPEVsWF--KDGQPLRSSDRFKVTYEGGtYTLTISNVQPDDSGKYTCVATNSAGEAEASAEL 88


                  ..
gi 1868077986 357 KV 358
Cdd:pfam07679  89 TV 90
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 279-343 1.07e-05

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 43.71  E-value: 1.07e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1868077986 279 EAHLGDTLTITCDTKQQGMTKVWVTPSNEQVLNQGANGTVTVSEDGSLRFEKVQVEDGGVYTCYA 343
Cdd:pfam13927  12 TVREGETVTLTCEATGSPPPTITWYKNGEPISSGSTRSRSLSGSNSTLTISNVTRSDAGTYTCVA 76
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 64-205 1.31e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 46.96  E-value: 1.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868077986  64 ALLDLSHNNLS----RLRAEWTPTRLINLHSLLLSHNHLNFISSE----AFVPVPNLRYLDLSSNHLH-----TLDEFLf 130
Cdd:cd00116   111 QELKLNNNGLGdrglRLLAKGLKDLPPALEKLVLGRNRLEGASCEalakALRANRDLKELNLANNGIGdagirALAEGL- 189

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868077986 131 SDLHALEVLLLYNNRIM---AVD-RYAFEDMAQLQKLYLSQNQISRFPLELIKDGNKLP--KLMLLDLSSNKLKKLPFTD 204
Cdd:cd00116   190 KANCNLEVLDLNNNGLTdegASAlAETLASLKSLEVLNLGDNNLTDAGAAALASALLSPniSLLTLSLSCNDITDDGAKD 269


                  .
gi 1868077986 205 L 205
Cdd:cd00116   270 L 270
IgI_Lingo-1 cd20969
Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing ...
 283-358 7.08e-05

Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1); The members here are composed of the immunoglobulin I-set (IgI) domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1). Human Lingo-1 is a central nervous system-specific transmembrane glycoprotein also known as LERN-1, which functions as a negative regulator of neuronal survival, axonal regeneration, and oligodendrocyte differentiation and myelination. Lingo-1 is a key component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. The ligand-binding ectodomain of human Lingo-1 contains a bimodular, kinked structure composed of leucine-rich repeat (LRR) and immunoglobulin (Ig)-like modules. Diseases associated with Lingo-1 include mental retardation, autosomal recessive 64 and essential tremor. The Ig superfamily (IgSF) is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Unlike the V-set, one of the distinctive features of I-set domains is the lack of a C" strand. The structure of the Lingo-1 lacks this strand and thus it belongs to the I-set of the IgSF. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors, the hemolymph protein hemolin, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, and the signaling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis.


Pssm-ID: 409561  Cd Length: 92  Bit Score: 41.61  E-value: 7.08e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1868077986 283 GDTLTITCdtKQQGM---TKVWVTPsNEQVLNQGANGTVTVSEDGSLRFEKVQVEDGGVYTCYAMGETFNETLSVELKV 358
Cdd:cd20969    17 GHTVQFVC--RADGDpppAILWLSP-RKHLVSAKSNGRLTVFPDGTLEVRYAQVQDNGTYLCIAANAGGNDSMPAHLHV 92
LRR_8 pfam13855
Leucine rich repeat;
159-223 7.62e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.59  E-value: 7.62e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1868077986 159 QLQKLYLSQNQISRFPLELIKDgnkLPKLMLLDLSSNKLKKLPFTDLQKLPAWVKngLYLHNNPL 223
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKG---LSNLKVLDLSNNLLTTLSPGAFSGLPSLRY--LDLSGNRL 61
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 286-343 9.85e-05

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 40.39  E-value: 9.85e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1868077986 286 LTITCDTKQQGMTKV-WVTPsNEQVLNQGANGTVTVSEDGSLRFEKVQVEDGGVYTCYA 343
Cdd:cd00096     1 VTLTCSASGNPPPTItWYKN-GKPLPPSSRDSRRSELGNGTLTISNVTLEDSGTYTCVA 58
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 66-197 3.91e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 42.85  E-value: 3.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868077986  66 LDLSHNNLSRLRAEWTPTRL---INLHSLLLSHNHLNFISSEAFVP----VPNLRYLDLSSNHLHTLD-EFLFSDLHA-- 135
Cdd:COG5238   269 LYLSGNQIGAEGAIALAKALqgnTTLTSLDLSVNRIGDEGAIALAEglqgNKTLHTLNLAYNGIGAQGaIALAKALQEnt 348

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1868077986 136 -LEVLLLYNNRI----MAVDRYAFEDMAQLQKLYLSQNQISRFPLELIKDGNKLPKLMLLDLSSNKL 197
Cdd:COG5238   349 tLHSLDLSDNQIgdegAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQTNRLHTLILDGNLI 415
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 110-150 7.31e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 37.22  E-value: 7.31e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1868077986 110 PNLRYLDLSSNHLHTLDefLFSDLHALEVL-LLYNNRIMAVD 150
Cdd:pfam12799   1 PNLEVLDLSNNQITDIP--PLAKLPNLETLdLSGNNKITDLS 40
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 66-174 7.42e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.92  E-value: 7.42e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868077986  66 LDLSHNNLSR---LraewtpTRLINLHSLLLSHNHLNfiSSEAFVPVPN--------LRYLDLSSNHLHTLDEflFSDLH 134
Cdd:cd21340    73 LYLGGNRISVvegL------ENLTNLEELHIENQRLP--PGEKLTFDPRslaalsnsLRVLNISGNNIDSLEP--LAPLR 142

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1868077986 135 ALEVLLLYNNRIMAVDR--YAFEDMAQLQKLYLSQNQISRFP 174
Cdd:cd21340   143 NLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKP 184
IgV_HHLA2 cd16091
Immunoglobulin Variable (IgV) domain in HERV-H LTR-associating 2 (HHLA2); The members here are ...
 325-358 1.83e-03

Immunoglobulin Variable (IgV) domain in HERV-H LTR-associating 2 (HHLA2); The members here are composed of the immunoglobulin variable (IgV) region in HERV-H LTR-associating 2 (HHLA2; also known as B7-H7/B7 homolog 7). HHLA2 is a member of the B7 family of immune regulatory proteins. Mature human HHLA2 consists of an extracellular domain (ECD) with three immunoglobulin-like domains, a transmembrane segment, and a cytoplasmic domain. HHLA2 is widely expressed in human cancers including non-small cell lung carcinoma (NSCLS), triple negative breast cancer (TNBC), and melanoma, but has limited expression on normal tissues. Interestingly, unlike other members of B7 family, HHLA2 is not expressed in mice or rats. HHLA2 functions as a T cell coinhibitory molecules as it inhibits the proliferation of activated CD4(+) and CD8(+) T cells and their cytokine production. Furthermore, HHLA2 is constitutively expressed on the surface of human monocytes and is induced on B cells after stimulation, however it is not inducible on T cells.


Pssm-ID: 409512  Cd Length: 107  Bit Score: 38.14  E-value: 1.83e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1868077986 325 SLRFEKVQVEDGGVYTCYAMGETFNETLSVELKV 358
Cdd:cd16091    74 SLLLRRVQLQDEGRYKCYTSTIIGNQESFVNLKV 107
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 88-152 2.04e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.77  E-value: 2.04e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1868077986  88 LHSLLLSHNHLNFISSeaFVPVPNLRYLDLSSNHLHTLDEF--LFSDLHALEVLLLYNNRIMAVDRY 152
Cdd:cd21340   122 LRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEELldLLSSWPSLRELDLTGNPVCKKPKY 186
LRRNT smart00013
Leucine rich repeat N-terminal domain;
34-63 3.44e-03

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 34.99  E-value: 3.44e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1868077986   34 CPANCLCASNILSCSKQQLPSVPQSLPSYT 63
Cdd:smart00013   2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDT 31
IgV_CEACAM_D1 cd05774
First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion ...
 302-358 3.45e-03

First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM); The members here are composed of the immunoglobulin (Ig)-like domain 1 in carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) proteins. The CEA family is a group of anchored or secreted glycoproteins, expressed by epithelial cells, leukocytes, endothelial cells, and placenta. The CEA family is divided into the CEACAM and pregnancy-specific glycoprotein (PSG) subfamilies. This group represents the CEACAM subfamily. CEACAM1 has many important cellular functions: it is a cell adhesion molecule and a signaling molecule that regulates the growth of tumor cells, an angiogenic factor, and a receptor for bacterial and viral pathogens, including mouse hepatitis virus (MHV). In mice, four isoforms of CEACAM1 generated by alternative splicing have either two (D1, D4) or four (D1-D4) Ig-like domains on the cell surface.


Pssm-ID: 409430  Cd Length: 105  Bit Score: 37.25  E-value: 3.45e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1868077986 302 VTPSNEQVLNQGANGTVTVSEDGSLRFEKVQVEDGGVYTCYAMGETFN-ETLSVELKV 358
Cdd:cd05774    48 IISTNSSTPGPAYSGRETIYPNGSLLIQNVTQKDTGFYTLQTITADLQtEQASVHLQV 105
IgI_2_MuSK cd20968
agrin-responsive second immunoglobulin-like domains (Ig2) of the Muscle-specific kinase (MuSK) ...
 314-357 5.95e-03

agrin-responsive second immunoglobulin-like domains (Ig2) of the Muscle-specific kinase (MuSK) ectodomain; a member of the I-set of Ig superfamily domains; The members here are composed of the second immunoglobulin-like (Ig) domains of the Muscle-specific kinase (MuSK) ectodomain. MuSK is a receptor tyrosine kinase specifically expressed in skeletal muscle, where it plays a central role in the formation and maintenance of the neuromuscular junction (NMJ). MuSK is activated by agrin, a neuron-derived heparan sulfate proteoglycan. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. The Ig superfamily (IgSF) is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Unlike the V-set, one of the distinctive features of I-set domains is the lack of a C" strand. The structure of the MuSK lacks this strand and thus it belongs to the I-set of the IgSF. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors, the hemolymph protein hemolin, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, and the signaling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis.


Pssm-ID: 409560 [Multi-domain]  Cd Length: 88  Bit Score: 36.07  E-value: 5.95e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1868077986 314 ANGTVTVSEDGSLRFEKVQVEDGGVYTCYA---MGETFNETLSVELK 357
Cdd:cd20968    42 ENNRIAVLESGSLRIHNVQKEDAGQYRCVAknsLGIAYSKPVTIEVE 88
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 54-197 7.19e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 39.06  E-value: 7.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868077986  54 SVPQSLPSYTAL--LDLSHNNLSRLRAEWTpTRLINLHSLLLSHNHLNFISSEAFVPVP--------------------- 110
Cdd:PLN00113  275 PIPPSIFSLQKLisLDLSDNSLSGEIPELV-IQLQNLEILHLFSNNFTGKIPVALTSLPrlqvlqlwsnkfsgeipknlg 353

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868077986 111 ---NLRYLDLSSNHLH-TLDEFLFSDLHaLEVLLLYNNRIMAVDRYAFEDMAQLQKLYLSQNQISRfplELIKDGNKLPK 186
Cdd:PLN00113  354 khnNLTVLDLSTNNLTgEIPEGLCSSGN-LFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSG---ELPSEFTKLPL 429

                         170
                  ....*....|.
gi 1868077986 187 LMLLDLSSNKL 197
Cdd:PLN00113  430 VYFLDISNNNL 440
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 323-359 7.61e-03

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 36.28  E-value: 7.61e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1868077986 323 DGSLRFEKVQVEDGGVYTCYAMG-ETFNETLSVELKVY 359
Cdd:pfam07686  72 DGSLTIQNLTLSDSGTYTCAVIPsGEGVFGKGTRLTVL 109
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 87-128 8.02e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.53  E-value: 8.02e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1868077986  87 NLHSLLLSHNHLNFIssEAFVPVPNLRYLDLSSN-HLHTLDEF 128
Cdd:pfam12799   2 NLEVLDLSNNQITDI--PPLAKLPNLETLDLSGNnKITDLSDL 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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