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Conserved domains on  [gi|1899709811|ref|XP_035892395|]
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toll-like receptor Tollo [Anopheles stephensi]

Protein Classification

toll/interleukin-1 receptor domain-containing protein( domain architecture ID 13320953)

toll/interleukin-1 receptor (TIR) domain-containing protein with leucine-rich repeats such as Rattus norvegicus toll-like receptor 4; the TIR domain is responsible for signal transduction in all toll-like receptors (TLR)

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
1089-1224 8.39e-41

Toll - interleukin 1 - resistance;


:

Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 147.08  E-value: 8.39e-41
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  1089 FDAFISYSSKDeaFVAEELAPMLENEDPSYKLCLHYRDFPVGAYIADNILQAVESSRRTIMVLSENFIKSEWCRFEFKSA 1168
Cdd:smart00255    2 YDVFISYSGKE--DVRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVAA 79
                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1899709811  1169 HHQVLRDRRRRLIVILLGEVPQ--KDLDPDIRLYLKTNtYLQWGDKL---FWEKLRFALPD 1224
Cdd:smart00255   80 LENALEEGGLRVIPIFYEVIPSdvRKQPGKFRKVFKKN-YLKWPEDEkeqFWKKALYAVPS 139
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
243-627 9.51e-28

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 117.73  E-value: 9.51e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  243 SNGLNYIADRAFEGLVSLSRLEISLNRLTNLPPELFSEAKHIKEIYLQNNSLNVLAPGIFSDLKQLLVLDLSNNELTSEW 322
Cdd:COG4886      7 SLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLL 86
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  323 INPATFRGLTKLILLDLSNNKIskleptiFRDLTSLQVLRMQENFIESIAENtFLELTALHTVILSNNRLSTVDhFTFSG 402
Cdd:COG4886     87 LGLTDLGDLTNLTELDLSGNEE-------LSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLP-EPLGN 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  403 LKSLTLLSLDYNRISRIDRqALRNHSTLQELHLNGNKLLQVPDALYDVPLLRTLDLGENHISSIDnASFRHMAHLYGLRL 482
Cdd:COG4886    158 LTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLP-EPLANLTNLETLDL 235
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  483 TENNIEIIRrgTFEAMKSLHILNLSQNRLKTVEQSSfdNNTKLQAIRLDGNYLTDIAglFTKLPNLLWLNISDNHLEVFD 562
Cdd:COG4886    236 SNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLK--LKELELLLGLNSLLLLLLLLN 309
                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1899709811  563 YALIPTGLQWLDIHANKITELGNYFEIESQLALSTIDASSNQLTEITGSAIPNSVELLYLNDNLI 627
Cdd:COG4886    310 LLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGL 374
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
37-408 9.79e-22

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 99.62  E-value: 9.79e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811   37 WDGYSEDDLTLLCRLRTINSELENTNFSVLHPENTVRLRLQCNDGLFfqsslspgsfkQLTKLHSLSIEYCKIANLSEgS 116
Cdd:COG4886     64 SLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELS-----------NLTNLESLDLSGNQLTDLPE-E 131
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  117 FQGLKQLTNLTLRthNTDWSSISLDIapqvfnSELSKLQRLDLSQNNMWSVPDgFICPLSRLTYLNLTHNRLRDLsvfhf 196
Cdd:COG4886    132 LANLTNLKELDLS--NNQLTDLPEPL------GNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDL----- 197
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  197 SASLSTRlskkcgSSIVTLDLSHNTIDNLPPAIfSGLGKLTDLRLQSNGLNYIADraFEGLVSLSRLEISLNRLTNLPPE 276
Cdd:COG4886    198 PEPLGNL------TNLEELDLSGNQLTDLPEPL-ANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPL 268
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  277 lfSEAKHIKEIYLQNNSLNVLAPGIFSDLKQLLVLDLSNNELTSEWINPATFRGLTKLILLDLSNNKISKLEPTIFrDLT 356
Cdd:COG4886    269 --ANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLAL-SLS 345
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1899709811  357 SLQVLRMQENFIESIAENTFLELTALHTVILSNNRLSTVDHFTFSGLKSLTL 408
Cdd:COG4886    346 LLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTT 397
LRR_8 pfam13855
Leucine rich repeat;
840-899 3.40e-10

Leucine rich repeat;


:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 56.76  E-value: 3.40e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  840 ELEILQLDHNLLTALNGFEFEGLDSLKELFLQYNRIAQIANHTFDHLHGLKILRLDHNRI 899
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
796-851 3.39e-08

Leucine rich repeat;


:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 51.37  E-value: 3.39e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1899709811  796 IYLDGNNFRSLGSHAFLGRKRLKILFLNGSSVETVSNRTFYGLKELEILQLDHNLL 851
Cdd:pfam13855    6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 super family cl38440
Leucine rich repeat;
616-660 9.45e-03

Leucine rich repeat;


The actual alignment was detected with superfamily member pfam13855:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.96  E-value: 9.45e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1899709811  616 SVELLYLNDNLISKVQSYTFFKKPNLTRVDLFGNKITTLDPNALR 660
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFS 46
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
1089-1224 8.39e-41

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 147.08  E-value: 8.39e-41
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  1089 FDAFISYSSKDeaFVAEELAPMLENEDPSYKLCLHYRDFPVGAYIADNILQAVESSRRTIMVLSENFIKSEWCRFEFKSA 1168
Cdd:smart00255    2 YDVFISYSGKE--DVRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVAA 79
                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1899709811  1169 HHQVLRDRRRRLIVILLGEVPQ--KDLDPDIRLYLKTNtYLQWGDKL---FWEKLRFALPD 1224
Cdd:smart00255   80 LENALEEGGLRVIPIFYEVIPSdvRKQPGKFRKVFKKN-YLKWPEDEkeqFWKKALYAVPS 139
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
243-627 9.51e-28

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 117.73  E-value: 9.51e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  243 SNGLNYIADRAFEGLVSLSRLEISLNRLTNLPPELFSEAKHIKEIYLQNNSLNVLAPGIFSDLKQLLVLDLSNNELTSEW 322
Cdd:COG4886      7 SLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLL 86
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  323 INPATFRGLTKLILLDLSNNKIskleptiFRDLTSLQVLRMQENFIESIAENtFLELTALHTVILSNNRLSTVDhFTFSG 402
Cdd:COG4886     87 LGLTDLGDLTNLTELDLSGNEE-------LSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLP-EPLGN 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  403 LKSLTLLSLDYNRISRIDRqALRNHSTLQELHLNGNKLLQVPDALYDVPLLRTLDLGENHISSIDnASFRHMAHLYGLRL 482
Cdd:COG4886    158 LTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLP-EPLANLTNLETLDL 235
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  483 TENNIEIIRrgTFEAMKSLHILNLSQNRLKTVEQSSfdNNTKLQAIRLDGNYLTDIAglFTKLPNLLWLNISDNHLEVFD 562
Cdd:COG4886    236 SNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLK--LKELELLLGLNSLLLLLLLLN 309
                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1899709811  563 YALIPTGLQWLDIHANKITELGNYFEIESQLALSTIDASSNQLTEITGSAIPNSVELLYLNDNLI 627
Cdd:COG4886    310 LLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGL 374
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
62-606 2.60e-23

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 107.63  E-value: 2.60e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811   62 NFSVLHPENTVRLrlqcndgLFFQSSLSpGSFKQLTKLHSlSIEYCKianlsegsFQGLkqLTNLTLRTHNTDWS--SIS 139
Cdd:PLN00113    22 NFSMLHAEELELL-------LSFKSSIN-DPLKYLSNWNS-SADVCL--------WQGI--TCNNSSRVVSIDLSgkNIS 82
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  140 LDIAPQVFnsELSKLQRLDLSQNNM-WSVPDGFICPLSRLTYLNLTHNrlrdlsvfHFSASlstrLSKKCGSSIVTLDLS 218
Cdd:PLN00113    83 GKISSAIF--RLPYIQTINLSNNQLsGPIPDDIFTTSSSLRYLNLSNN--------NFTGS----IPRGSIPNLETLDLS 148
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  219 HNTIDNlppAIFSGLGKLTDLRLQSNGLNYIADRAFEGLVSLSRLE---ISLNRLTNLPPELFSEAKHIKEIYLQNN--- 292
Cdd:PLN00113   149 NNMLSG---EIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEfltLASNQLVGQIPRELGQMKSLKWIYLGYNnls 225
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  293 -----------SLNVL----------APGIFSDLKQLLVLDLSNNELTSEwINPATFrGLTKLILLDLSNNKISKLEPTI 351
Cdd:PLN00113   226 geipyeiggltSLNHLdlvynnltgpIPSSLGNLKNLQYLFLYQNKLSGP-IPPSIF-SLQKLISLDLSDNSLSGEIPEL 303
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  352 FRDLTSLQVLRMQENFIESIAENTFLELTALHTVILSNNRLSTVDHFTFSGLKSLTLLSLDYNRISRIDRQALRNHSTLQ 431
Cdd:PLN00113   304 VIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLF 383
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  432 ELHLNGNKLL-QVPDALYDVPLLRTLDLGENHISSIDNASFRHMAHLYGLRLTENNIEIIRRGTFEAMKSLHILNLSQNR 510
Cdd:PLN00113   384 KLILFSNSLEgEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNK 463
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  511 LKTVEQSSFdNNTKLQAIRLDGNYLTD-IAGLFTKLPNLLWLNISDNHLEvfdyALIPTGLQW------LDIHANKITEl 583
Cdd:PLN00113   464 FFGGLPDSF-GSKRLENLDLSRNQFSGaVPRKLGSLSELMQLKLSENKLS----GEIPDELSSckklvsLDLSHNQLSG- 537
                          570       580
                   ....*....|....*....|....*..
gi 1899709811  584 gnyfEIESQLA----LSTIDASSNQLT 606
Cdd:PLN00113   538 ----QIPASFSempvLSQLDLSQNQLS 560
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
37-408 9.79e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 99.62  E-value: 9.79e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811   37 WDGYSEDDLTLLCRLRTINSELENTNFSVLHPENTVRLRLQCNDGLFfqsslspgsfkQLTKLHSLSIEYCKIANLSEgS 116
Cdd:COG4886     64 SLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELS-----------NLTNLESLDLSGNQLTDLPE-E 131
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  117 FQGLKQLTNLTLRthNTDWSSISLDIapqvfnSELSKLQRLDLSQNNMWSVPDgFICPLSRLTYLNLTHNRLRDLsvfhf 196
Cdd:COG4886    132 LANLTNLKELDLS--NNQLTDLPEPL------GNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDL----- 197
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  197 SASLSTRlskkcgSSIVTLDLSHNTIDNLPPAIfSGLGKLTDLRLQSNGLNYIADraFEGLVSLSRLEISLNRLTNLPPE 276
Cdd:COG4886    198 PEPLGNL------TNLEELDLSGNQLTDLPEPL-ANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPL 268
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  277 lfSEAKHIKEIYLQNNSLNVLAPGIFSDLKQLLVLDLSNNELTSEWINPATFRGLTKLILLDLSNNKISKLEPTIFrDLT 356
Cdd:COG4886    269 --ANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLAL-SLS 345
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1899709811  357 SLQVLRMQENFIESIAENTFLELTALHTVILSNNRLSTVDHFTFSGLKSLTL 408
Cdd:COG4886    346 LLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTT 397
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
1092-1198 2.22e-20

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 87.76  E-value: 2.22e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811 1092 FISYSSKDEAFVaEELAPMLENEDpsYKLCLHYRDFPVGAYIADNILQAVESSRRTIMVLSENFIKSEWCRFEFKSAHHq 1171
Cdd:pfam13676    2 FISYAGEDRAWA-EWLADALEAAG--YRVWLDRWDIRPGDDWVEEIEEAIENSDRVLVVLSPNYLESPWCRAEWEAALA- 77
                           90       100
                   ....*....|....*....|....*..
gi 1899709811 1172 vLRDRRRRLIVILLGEvpqKDLDPDIR 1198
Cdd:pfam13676   78 -DPEGRKRLIPVRLEC---DLELPGLA 100
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
331-509 6.08e-18

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 84.07  E-value: 6.08e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  331 LTKLILLDLSNNKISKLEptIFRDLTSLQVLRMQENFIESIAENTFLE-LTALHtviLSNNRLSTVDHFtfSGLKSLTLL 409
Cdd:cd21340      1 LKRITHLYLNDKNITKID--NLSLCKNLKVLYLYDNKITKIENLEFLTnLTHLY---LQNNQIEKIENL--ENLVNLKKL 73
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  410 SLDYNRISRIDrqALRNHSTLQELHL------NGNKLLQVPDALYDV-PLLRTLDLGENHISSIDnaSFRHMAHLYGLRL 482
Cdd:cd21340     74 YLGGNRISVVE--GLENLTNLEELHIenqrlpPGEKLTFDPRSLAALsNSLRVLNISGNNIDSLE--PLAPLRNLEQLDA 149
                          170       180
                   ....*....|....*....|....*....
gi 1899709811  483 TENNIEIIRR--GTFEAMKSLHILNLSQN 509
Cdd:cd21340    150 SNNQISDLEEllDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
283-344 4.11e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 62.54  E-value: 4.11e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1899709811  283 HIKEIYLQNNSLNVLAPGIFSDLKQLLVLDLSNNELTSewINPATFRGLTKLILLDLSNNKI 344
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT--LSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
840-899 3.40e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 56.76  E-value: 3.40e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  840 ELEILQLDHNLLTALNGFEFEGLDSLKELFLQYNRIAQIANHTFDHLHGLKILRLDHNRI 899
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
118-321 5.53e-09

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 59.29  E-value: 5.53e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  118 QGLKQLTNLTLRTHNTdwSSISLDiAPQVFNSELSK--LQRLDLSQNNMWSVPDGFIC-----PLSRLTYLNLTHNRLRD 190
Cdd:cd00116     75 QGLTKGCGLQELDLSD--NALGPD-GCGVLESLLRSssLQELKLNNNGLGDRGLRLLAkglkdLPPALEKLVLGRNRLEG 151
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  191 LSvfhfSASLSTRLSKKCgsSIVTLDLSHNTI-DNLPPAIFSGL---GKLTDLRLQSNGLNYIADRAFEGLV----SLSR 262
Cdd:cd00116    152 AS----CEALAKALRANR--DLKELNLANNGIgDAGIRALAEGLkanCNLEVLDLNNNGLTDEGASALAETLaslkSLEV 225
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1899709811  263 LEISLNRLTN-----LPPELFSEAKHIKEIYLQNNSLNVLAPGIFS----DLKQLLVLDLSNNELTSE 321
Cdd:cd00116    226 LNLGDNNLTDagaaaLASALLSPNISLLTLSLSCNDITDDGAKDLAevlaEKESLLELDLRGNKFGEE 293
LRR_8 pfam13855
Leucine rich repeat;
796-851 3.39e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 51.37  E-value: 3.39e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1899709811  796 IYLDGNNFRSLGSHAFLGRKRLKILFLNGSSVETVSNRTFYGLKELEILQLDHNLL 851
Cdd:pfam13855    6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
794-919 3.60e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 57.25  E-value: 3.60e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  794 TQIYLDGNNFRSLGShAFLGRKRLKILFLNGSSVETVSNrTFYGLKELEILQLDHNLLTALnGFEFEGLDSLKELFLQYN 873
Cdd:COG4886    139 KELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGN 215
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1899709811  874 RIAQIANhTFDHLHGLKILRLDHNRIVEFNVWHLPKQLNDIRLAFN 919
Cdd:COG4886    216 QLTDLPE-PLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNN 260
LRR_8 pfam13855
Leucine rich repeat;
210-270 2.50e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.67  E-value: 2.50e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1899709811  210 SSIVTLDLSHNTIDNLPPAIFSGLGKLTDLRLQSNGLNYIADRAFEGLVSLSRLEISLNRL 270
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
794-899 8.64e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 48.24  E-value: 8.64e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  794 TQIYLDGNNFRSLGSHAFLgrKRLKILFLNGSSVETVSNrtFYGLKELEILQLDHNLLTALNGFEfeGLDSLKELFLQYN 873
Cdd:cd21340      5 THLYLNDKNITKIDNLSLC--KNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIENLE--NLVNLKKLYLGGN 78
                           90       100
                   ....*....|....*....|....*.
gi 1899709811  874 RIAQIANhtFDHLHGLKILRLDHNRI 899
Cdd:cd21340     79 RISVVEG--LENLTNLEELHIENQRL 102
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
794-920 1.38e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 44.78  E-value: 1.38e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  794 TQIYLDGNNFRSLGShaFLGRKRLKILFLNGSSVETVSNrtFYGLKELEILQLDHNLLTALNGFEFEG------LDSLKE 867
Cdd:cd21340     49 THLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVVEG--LENLTNLEELHIENQRLPPGEKLTFDPrslaalSNSLRV 124
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1899709811  868 LFLQYNRIAQIANhtFDHLHGLKILRLDHNRIVEFN--VWHLPK--QLNDIRLAFNP 920
Cdd:cd21340    125 LNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEelLDLLSSwpSLRELDLTGNP 179
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
831-899 7.92e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 43.38  E-value: 7.92e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1899709811  831 SNRTFYGLKELEILQLDHNLLTALnGFEFEGLDSLKELFLQYNRIAQIANhTFDHLHGLKILRLDHNRI 899
Cdd:COG4886    105 GNEELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQL 171
LRR_8 pfam13855
Leucine rich repeat;
616-660 9.45e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.96  E-value: 9.45e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1899709811  616 SVELLYLNDNLISKVQSYTFFKKPNLTRVDLFGNKITTLDPNALR 660
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFS 46
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
1089-1224 8.39e-41

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 147.08  E-value: 8.39e-41
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  1089 FDAFISYSSKDeaFVAEELAPMLENEDPSYKLCLHYRDFPVGAYIADNILQAVESSRRTIMVLSENFIKSEWCRFEFKSA 1168
Cdd:smart00255    2 YDVFISYSGKE--DVRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVAA 79
                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1899709811  1169 HHQVLRDRRRRLIVILLGEVPQ--KDLDPDIRLYLKTNtYLQWGDKL---FWEKLRFALPD 1224
Cdd:smart00255   80 LENALEEGGLRVIPIFYEVIPSdvRKQPGKFRKVFKKN-YLKWPEDEkeqFWKKALYAVPS 139
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
243-627 9.51e-28

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 117.73  E-value: 9.51e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  243 SNGLNYIADRAFEGLVSLSRLEISLNRLTNLPPELFSEAKHIKEIYLQNNSLNVLAPGIFSDLKQLLVLDLSNNELTSEW 322
Cdd:COG4886      7 SLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLL 86
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  323 INPATFRGLTKLILLDLSNNKIskleptiFRDLTSLQVLRMQENFIESIAENtFLELTALHTVILSNNRLSTVDhFTFSG 402
Cdd:COG4886     87 LGLTDLGDLTNLTELDLSGNEE-------LSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLP-EPLGN 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  403 LKSLTLLSLDYNRISRIDRqALRNHSTLQELHLNGNKLLQVPDALYDVPLLRTLDLGENHISSIDnASFRHMAHLYGLRL 482
Cdd:COG4886    158 LTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLP-EPLANLTNLETLDL 235
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  483 TENNIEIIRrgTFEAMKSLHILNLSQNRLKTVEQSSfdNNTKLQAIRLDGNYLTDIAglFTKLPNLLWLNISDNHLEVFD 562
Cdd:COG4886    236 SNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLK--LKELELLLGLNSLLLLLLLLN 309
                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1899709811  563 YALIPTGLQWLDIHANKITELGNYFEIESQLALSTIDASSNQLTEITGSAIPNSVELLYLNDNLI 627
Cdd:COG4886    310 LLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGL 374
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
171-587 4.84e-27

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 115.80  E-value: 4.84e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  171 FICPLSRLTYLNLTHNRLRDLSVFHFSASLSTRLSKKCGSSIVTLDLSHNTIDNLPPAIFSGLGKLTDLRLQSNGLNYIA 250
Cdd:COG4886      9 TLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLG 88
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  251 DRAFEGLVSLSRLEISLNrltnlppELFSEAKHIKEIYLQNNSLNVLaPGIFSDLKQLLVLDLSNNELTSewiNPATFRG 330
Cdd:COG4886     89 LTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTD---LPEPLGN 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  331 LTKLILLDLSNNKISKLePTIFRDLTSLQVLRMQENFIESIAEnTFLELTALHTVILSNNRLSTVDHfTFSGLKSLTLLS 410
Cdd:COG4886    158 LTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLD 234
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  411 LDYNRISRIDrqALRNHSTLQELHLNGNKLLQVPDaLYDVPLLRTLDLGENHISSIdnaSFRHMAHLYGLRLTENNIEII 490
Cdd:COG4886    235 LSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPP-LANLTNLKTLDLSNNQLTDL---KLKELELLLGLNSLLLLLLLL 308
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  491 RRGTFEAMKSLHILNLSQNRLKTVEQSSFDNNTKLQAIRLDGNYLTDIAGLFTKLPNLLWLNISDNHLEVFDYALIPTGL 570
Cdd:COG4886    309 NLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLT 388
                          410
                   ....*....|....*..
gi 1899709811  571 QWLDIHANKITELGNYF 587
Cdd:COG4886    389 LLLLLLTTTAGVLLLTL 405
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
265-649 8.83e-27

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 114.65  E-value: 8.83e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  265 ISLNRLTNLPPELFSEAKHIKEIYLQNNSLNVLAPGIFSDLKQLLVLDLSNNELTSEWINPATFRGLTKLILLDLSNNKI 344
Cdd:COG4886      5 LLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSL 84
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  345 SKLEPTIFRDLTSLQVLRMQENfiesiaeNTFLELTALHTVILSNNRLSTVDHFtFSGLKSLTLLSLDYNRISRIDRqAL 424
Cdd:COG4886     85 LLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLPE-PL 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  425 RNHSTLQELHLNGNKLLQVPDALYDVPLLRTLDLGENHISSIDNAsfrhmahlyglrltennieiirrgtFEAMKSLHIL 504
Cdd:COG4886    156 GNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEP-------------------------LGNLTNLEEL 210
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  505 NLSQNRLKTVEqSSFDNNTKLQAIRLDGNYLTDIAGLfTKLPNLLWLNISDNHLEVFDYALIPTGLQWLDIHANKITELG 584
Cdd:COG4886    211 DLSGNQLTDLP-EPLANLTNLETLDLSNNQLTDLPEL-GNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLK 288
                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1899709811  585 -NYFEIESQLALSTIDASSNQLTEITGSAIPNSVELLYLNDNLISKVQSYTFFKKPNLTRVDLFGN 649
Cdd:COG4886    289 lKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLL 354
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
95-502 1.47e-25

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 111.18  E-value: 1.47e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811   95 QLTKLHSLSIEYCKIANLSEGSFQGLKQLTNLTLRTHNTDWSSISLDIAPQVFNSELSKLQRLDLSQNNMWSVPDGFICP 174
Cdd:COG4886      2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  175 LSRLTYLNLTHNRLRDLSVFhfsaSLSTRLSKKCGSSIVTLDLSHNTIDNLPPAIfSGLGKLTDLRLQSNGLNYIADrAF 254
Cdd:COG4886     82 LSLLLLGLTDLGDLTNLTEL----DLSGNEELSNLTNLESLDLSGNQLTDLPEEL-ANLTNLKELDLSNNQLTDLPE-PL 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  255 EGLVSLSRLEISLNRLTNLPPELfSEAKHIKEIYLQNNSLNVLaPGIFSDLKQLLVLDLSNNELTSEwinPATFRGLTKL 334
Cdd:COG4886    156 GNLTNLKSLDLSNNQLTDLPEEL-GNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDL---PEPLANLTNL 230
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  335 ILLDLSNNKISKLEptIFRDLTSLQVLRMQENFIESIAENtfLELTALHTVILSNNRLSTVDHFTFSGLKSLTLLSLDYN 414
Cdd:COG4886    231 ETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPL--ANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLL 306
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  415 RISRIDRQALRNHSTLQELHLNGNKLLQVPDALYDVPLLRTLDLGENHISSIDNASFRHMAHLYGLRLTENNIEIIRRGT 494
Cdd:COG4886    307 LLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLL 386

                   ....*...
gi 1899709811  495 FEAMKSLH 502
Cdd:COG4886    387 LTLLLLLL 394
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
62-606 2.60e-23

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 107.63  E-value: 2.60e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811   62 NFSVLHPENTVRLrlqcndgLFFQSSLSpGSFKQLTKLHSlSIEYCKianlsegsFQGLkqLTNLTLRTHNTDWS--SIS 139
Cdd:PLN00113    22 NFSMLHAEELELL-------LSFKSSIN-DPLKYLSNWNS-SADVCL--------WQGI--TCNNSSRVVSIDLSgkNIS 82
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  140 LDIAPQVFnsELSKLQRLDLSQNNM-WSVPDGFICPLSRLTYLNLTHNrlrdlsvfHFSASlstrLSKKCGSSIVTLDLS 218
Cdd:PLN00113    83 GKISSAIF--RLPYIQTINLSNNQLsGPIPDDIFTTSSSLRYLNLSNN--------NFTGS----IPRGSIPNLETLDLS 148
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  219 HNTIDNlppAIFSGLGKLTDLRLQSNGLNYIADRAFEGLVSLSRLE---ISLNRLTNLPPELFSEAKHIKEIYLQNN--- 292
Cdd:PLN00113   149 NNMLSG---EIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEfltLASNQLVGQIPRELGQMKSLKWIYLGYNnls 225
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  293 -----------SLNVL----------APGIFSDLKQLLVLDLSNNELTSEwINPATFrGLTKLILLDLSNNKISKLEPTI 351
Cdd:PLN00113   226 geipyeiggltSLNHLdlvynnltgpIPSSLGNLKNLQYLFLYQNKLSGP-IPPSIF-SLQKLISLDLSDNSLSGEIPEL 303
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  352 FRDLTSLQVLRMQENFIESIAENTFLELTALHTVILSNNRLSTVDHFTFSGLKSLTLLSLDYNRISRIDRQALRNHSTLQ 431
Cdd:PLN00113   304 VIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLF 383
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  432 ELHLNGNKLL-QVPDALYDVPLLRTLDLGENHISSIDNASFRHMAHLYGLRLTENNIEIIRRGTFEAMKSLHILNLSQNR 510
Cdd:PLN00113   384 KLILFSNSLEgEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNK 463
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  511 LKTVEQSSFdNNTKLQAIRLDGNYLTD-IAGLFTKLPNLLWLNISDNHLEvfdyALIPTGLQW------LDIHANKITEl 583
Cdd:PLN00113   464 FFGGLPDSF-GSKRLENLDLSRNQFSGaVPRKLGSLSELMQLKLSENKLS----GEIPDELSSckklvsLDLSHNQLSG- 537
                          570       580
                   ....*....|....*....|....*..
gi 1899709811  584 gnyfEIESQLA----LSTIDASSNQLT 606
Cdd:PLN00113   538 ----QIPASFSempvLSQLDLSQNQLS 560
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
44-463 5.77e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 100.39  E-value: 5.77e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811   44 DLTLLCRLRTINSELENTNFSVLHPENTVRLRLQCNDGLFFQSSLSPGSFKQLTKLHSLSIEYCKIANLSEGSFQGLKQL 123
Cdd:COG4886     13 LLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDL 92
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  124 TNLTLRTHntdwssisLDIAPQVFNSELSKLQRLDLSQNNMWSVPDgFICPLSRLTYLNLTHNRLRDLSvfhfsASLStR 203
Cdd:COG4886     93 GDLTNLTE--------LDLSGNEELSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLP-----EPLG-N 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  204 LSKkcgssIVTLDLSHNTIDNLPPAIfSGLGKLTDLRLQSNGLNYIADrAFEGLVSLSRLEISLNRLTNLPPELfSEAKH 283
Cdd:COG4886    158 LTN-----LKSLDLSNNQLTDLPEEL-GNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDLPEPL-ANLTN 229
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  284 IKEIYLQNNSLNVLApgIFSDLKQLLVLDLSNNELTSewINPATfrGLTKLILLDLSNNKISKLEptiFRDLTSLQVLRM 363
Cdd:COG4886    230 LETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTD--LPPLA--NLTNLKTLDLSNNQLTDLK---LKELELLLGLNS 300
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  364 QENFIESIAENTFLELTALHTVILSNNRLSTVDHFTFSGLKSLTLLSLDYNRISRIDRQALRNHSTLQELHLNGNKLLQV 443
Cdd:COG4886    301 LLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLL 380
                          410       420
                   ....*....|....*....|
gi 1899709811  444 PDALYDVPLLRTLDLGENHI 463
Cdd:COG4886    381 TLALLLLTLLLLLLTTTAGV 400
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
37-408 9.79e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 99.62  E-value: 9.79e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811   37 WDGYSEDDLTLLCRLRTINSELENTNFSVLHPENTVRLRLQCNDGLFfqsslspgsfkQLTKLHSLSIEYCKIANLSEgS 116
Cdd:COG4886     64 SLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELS-----------NLTNLESLDLSGNQLTDLPE-E 131
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  117 FQGLKQLTNLTLRthNTDWSSISLDIapqvfnSELSKLQRLDLSQNNMWSVPDgFICPLSRLTYLNLTHNRLRDLsvfhf 196
Cdd:COG4886    132 LANLTNLKELDLS--NNQLTDLPEPL------GNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDL----- 197
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  197 SASLSTRlskkcgSSIVTLDLSHNTIDNLPPAIfSGLGKLTDLRLQSNGLNYIADraFEGLVSLSRLEISLNRLTNLPPE 276
Cdd:COG4886    198 PEPLGNL------TNLEELDLSGNQLTDLPEPL-ANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPL 268
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  277 lfSEAKHIKEIYLQNNSLNVLAPGIFSDLKQLLVLDLSNNELTSEWINPATFRGLTKLILLDLSNNKISKLEPTIFrDLT 356
Cdd:COG4886    269 --ANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLAL-SLS 345
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1899709811  357 SLQVLRMQENFIESIAENTFLELTALHTVILSNNRLSTVDHFTFSGLKSLTL 408
Cdd:COG4886    346 LLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTT 397
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
311-693 2.07e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 98.47  E-value: 2.07e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  311 LDLSNNELTSEWINPATFRGLTKLILLDLSNNKISKLEPTIFRDLTSLQVLRMQENFIESIAENTFLELTALHTVILSNN 390
Cdd:COG4886      1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  391 RLSTVD--HFTFSGLKSLTLLSLDYNrisridrQALRNHSTLQELHLNGNKLLQVPDALYDVPLLRTLDLGENHISSIDN 468
Cdd:COG4886     81 LLSLLLlgLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPE 153
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  469 AsfrhmahlyglrltennieiirrgtFEAMKSLHILNLSQNRLKTVEqSSFDNNTKLQAIRLDGNYLTDIAGLFTKLPNL 548
Cdd:COG4886    154 P-------------------------LGNLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDLPEPLGNLTNL 207
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  549 LWLNISDNHLEVFDYALIP-TGLQWLDIHANKITELGnyfEIESQLALSTIDASSNQLTEITGSAIPNSVELLYLNDNLI 627
Cdd:COG4886    208 EELDLSGNQLTDLPEPLANlTNLETLDLSNNQLTDLP---ELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQL 284
                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1899709811  628 SKVQSYTFFKKPNLTRVDLFGNKITTLDPNALRISAVPDDRPLPEFYIGGNPYQCDCNLNWLQKSN 693
Cdd:COG4886    285 TDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALL 350
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
55-445 7.26e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 96.93  E-value: 7.26e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811   55 NSELENTNFSVLHPENTVRLRLQCNDGLFFQSSLSPGSFKQLTKLHSLSIEYCKianlsegSFQGLKQLTNLTLrtHNTD 134
Cdd:COG4886     54 SLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDL--SGNQ 124
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  135 WSSISLDIApqvfnsELSKLQRLDLSQNNMWSVPDgFICPLSRLTYLNLTHNRLRDLSvfhfsASLStRLSKkcgssIVT 214
Cdd:COG4886    125 LTDLPEELA------NLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLP-----EELG-NLTN-----LKE 186
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  215 LDLSHNTIDNLPPAIfSGLGKLTDLRLQSNGLNYIADrAFEGLVSLSRLEISLNRLTNLPPelFSEAKHIKEIYLQNNSL 294
Cdd:COG4886    187 LDLSNNQITDLPEPL-GNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQL 262
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  295 NVLAPgiFSDLKQLLVLDLSNNELTS---EWINPATFRGLTKLILLDLSNNKISKLEPTIFRDLTSLQVLRMQENFIESI 371
Cdd:COG4886    263 TDLPP--LANLTNLKTLDLSNNQLTDlklKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTL 340
                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1899709811  372 AENTFLELTALHTVILSNNRLSTVDHFTFSGLKSLTLLSLDYNRISRIDRQALRNHSTLQELHLNGNKLLQVPD 445
Cdd:COG4886    341 ALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVNTE 414
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
1092-1198 2.22e-20

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 87.76  E-value: 2.22e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811 1092 FISYSSKDEAFVaEELAPMLENEDpsYKLCLHYRDFPVGAYIADNILQAVESSRRTIMVLSENFIKSEWCRFEFKSAHHq 1171
Cdd:pfam13676    2 FISYAGEDRAWA-EWLADALEAAG--YRVWLDRWDIRPGDDWVEEIEEAIENSDRVLVVLSPNYLESPWCRAEWEAALA- 77
                           90       100
                   ....*....|....*....|....*..
gi 1899709811 1172 vLRDRRRRLIVILLGEvpqKDLDPDIR 1198
Cdd:pfam13676   78 -DPEGRKRLIPVRLEC---DLELPGLA 100
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
331-509 6.08e-18

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 84.07  E-value: 6.08e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  331 LTKLILLDLSNNKISKLEptIFRDLTSLQVLRMQENFIESIAENTFLE-LTALHtviLSNNRLSTVDHFtfSGLKSLTLL 409
Cdd:cd21340      1 LKRITHLYLNDKNITKID--NLSLCKNLKVLYLYDNKITKIENLEFLTnLTHLY---LQNNQIEKIENL--ENLVNLKKL 73
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  410 SLDYNRISRIDrqALRNHSTLQELHL------NGNKLLQVPDALYDV-PLLRTLDLGENHISSIDnaSFRHMAHLYGLRL 482
Cdd:cd21340     74 YLGGNRISVVE--GLENLTNLEELHIenqrlpPGEKLTFDPRSLAALsNSLRVLNISGNNIDSLE--PLAPLRNLEQLDA 149
                          170       180
                   ....*....|....*....|....*....
gi 1899709811  483 TENNIEIIRR--GTFEAMKSLHILNLSQN 509
Cdd:cd21340    150 SNNQISDLEEllDLLSSWPSLRELDLTGN 178
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
1089-1184 3.39e-14

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 71.63  E-value: 3.39e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811 1089 FDAFISYSSKD--EAFVAEELAPMLENedpSYKLCLHYRDFPVGAYIADNILQAVESSRRTIMVLSENFIKSEWCRFEFK 1166
Cdd:pfam01582    1 YDVFLSFRGSDtrEWFVSHLLKELKQK---GIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDELV 77
                           90
                   ....*....|....*...
gi 1899709811 1167 SAHHQVLRDrrrRLIVIL 1184
Cdd:pfam01582   78 KILECALDL---GQKVIP 92
LRR_8 pfam13855
Leucine rich repeat;
283-344 4.11e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 62.54  E-value: 4.11e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1899709811  283 HIKEIYLQNNSLNVLAPGIFSDLKQLLVLDLSNNELTSewINPATFRGLTKLILLDLSNNKI 344
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT--LSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
175-427 4.24e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 64.04  E-value: 4.24e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  175 LSRLTYLNLTHNRLRDLSVFHFSASLStrlskkcgssivTLDLSHNTIDNLPPaiFSGLGKLTDLRLQSNglnyiadraf 254
Cdd:cd21340      1 LKRITHLYLNDKNITKIDNLSLCKNLK------------VLYLYDNKITKIEN--LEFLTNLTHLYLQNN---------- 56
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  255 eglvSLSRLEiSLNRLTNLppelfseakhiKEIYLQNNSLNVLApGiFSDLKQLLVLDLSNNELTSE---WINPATFRGL 331
Cdd:cd21340     57 ----QIEKIE-NLENLVNL-----------KKLYLGGNRISVVE-G-LENLTNLEELHIENQRLPPGeklTFDPRSLAAL 118
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  332 TK-LILLDLSNNKISKLEPtiFRDLTSLQVLRMQENFIESIAE--NTFLELTALHTVILSNNRLSTVDHF-----TFSGl 403
Cdd:cd21340    119 SNsLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKPKYrdkiiLASK- 195
                          250       260
                   ....*....|....*....|....
gi 1899709811  404 kslTLLSLDYNRISRIDRQALRNH 427
Cdd:cd21340    196 ---SLEVLDGKEITDTERQFLKRL 216
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
233-438 2.06e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 62.11  E-value: 2.06e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  233 LGKLTDLRLQSNGLNYIadrafeglvslsrleislnrltnlppELFSEAKHIKEIYLQNNSLNVLAPgiFSDLKQLLVLD 312
Cdd:cd21340      1 LKRITHLYLNDKNITKI--------------------------DNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLY 52
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  313 LSNNELTSewINPatFRGLTKLILLDLSNNKISKLEPtiFRDLTSLQVL-----RMQENF--------IESIAENtflel 379
Cdd:cd21340     53 LQNNQIEK--IEN--LENLVNLKKLYLGGNRISVVEG--LENLTNLEELhienqRLPPGEkltfdprsLAALSNS----- 121
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1899709811  380 taLHTVILSNNRLSTVDhfTFSGLKSLTLLSLDYNRISRIDR--QALRNHSTLQELHLNGN 438
Cdd:cd21340    122 --LRVLNISGNNIDSLE--PLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
840-899 3.40e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 56.76  E-value: 3.40e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  840 ELEILQLDHNLLTALNGFEFEGLDSLKELFLQYNRIAQIANHTFDHLHGLKILRLDHNRI 899
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
382-440 6.95e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.99  E-value: 6.95e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1899709811  382 LHTVILSNNRLSTVDHFTFSGLKSLTLLSLDYNRISRIDRQALRNHSTLQELHLNGNKL 440
Cdd:pfam13855    3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
90-403 1.70e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 62.56  E-value: 1.70e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811   90 PGSFKQLTKLHSLSIEYCKIANLSEGSFQGLKQLTNLTLRThntdwSSISLDIAPQVFnsELSKLQRLDLSQNNMWSVPD 169
Cdd:PLN00113   253 PSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSD-----NSLSGEIPELVI--QLQNLEILHLFSNNFTGKIP 325
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  170 GFICPLSRLTYLNLTHNRL-----------RDLSVFHFSA-SLSTRLSKKCGSS--IVTLDLSHNTIDNLPPAIFSGLGK 235
Cdd:PLN00113   326 VALTSLPRLQVLQLWSNKFsgeipknlgkhNNLTVLDLSTnNLTGEIPEGLCSSgnLFKLILFSNSLEGEIPKSLGACRS 405
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  236 LTDLRLQSNGLN-------------------------YIADRAFE----GLVSLSR------------------LEISLN 268
Cdd:PLN00113   406 LRRVRLQDNSFSgelpseftklplvyfldisnnnlqgRINSRKWDmpslQMLSLARnkffgglpdsfgskrlenLDLSRN 485
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  269 RLTNLPPELFSEAKHIKEIYLQNNSLNVLAPGIFSDLKQLLVLDLSNNELTSEWinPATFRGLTKLILLDLSNNKISKLE 348
Cdd:PLN00113   486 QFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQI--PASFSEMPVLSQLDLSQNQLSGEI 563
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1899709811  349 PTIFRDLTSLQVLRMQENFIESIAENT--FLELTAlhTVILSNNRLSTVDhfTFSGL 403
Cdd:PLN00113   564 PKNLGNVESLVQVNISHNHLHGSLPSTgaFLAINA--SAVAGNIDLCGGD--TTSGL 616
LRR_8 pfam13855
Leucine rich repeat;
816-875 2.93e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.45  E-value: 2.93e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  816 RLKILFLNGSSVETVSNRTFYGLKELEILQLDHNLLTALNGFEFEGLDSLKELFLQYNRI 875
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
118-321 5.53e-09

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 59.29  E-value: 5.53e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  118 QGLKQLTNLTLRTHNTdwSSISLDiAPQVFNSELSK--LQRLDLSQNNMWSVPDGFIC-----PLSRLTYLNLTHNRLRD 190
Cdd:cd00116     75 QGLTKGCGLQELDLSD--NALGPD-GCGVLESLLRSssLQELKLNNNGLGDRGLRLLAkglkdLPPALEKLVLGRNRLEG 151
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  191 LSvfhfSASLSTRLSKKCgsSIVTLDLSHNTI-DNLPPAIFSGL---GKLTDLRLQSNGLNYIADRAFEGLV----SLSR 262
Cdd:cd00116    152 AS----CEALAKALRANR--DLKELNLANNGIgDAGIRALAEGLkanCNLEVLDLNNNGLTDEGASALAETLaslkSLEV 225
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1899709811  263 LEISLNRLTN-----LPPELFSEAKHIKEIYLQNNSLNVLAPGIFS----DLKQLLVLDLSNNELTSE 321
Cdd:cd00116    226 LNLGDNNLTDagaaaLASALLSPNISLLTLSLSCNDITDDGAKDLAevlaEKESLLELDLRGNKFGEE 293
LRR_8 pfam13855
Leucine rich repeat;
451-511 6.10e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 53.30  E-value: 6.10e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1899709811  451 PLLRTLDLGENHISSIDNASFRHMAHLYGLRLTENNIEIIRRGTFEAMKSLHILNLSQNRL 511
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
259-318 6.41e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 53.30  E-value: 6.41e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  259 SLSRLEISLNRLTNLPPELFSEAKHIKEIYLQNNSLNVLAPGIFSDLKQLLVLDLSNNEL 318
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
307-366 1.27e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.53  E-value: 1.27e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  307 QLLVLDLSNNELTSewINPATFRGLTKLILLDLSNNKISKLEPTIFRDLTSLQVLRMQEN 366
Cdd:pfam13855    2 NLRSLDLSNNRLTS--LDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
433-653 1.48e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 56.72  E-value: 1.48e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  433 LHLNGNKLLQVPDaLYDVPLLRTLDLGENHISSIDN-ASFRHMAHLYglrLTENNIEIIRRgtFEAMKSLHILNLSQNRL 511
Cdd:cd21340      7 LYLNDKNITKIDN-LSLCKNLKVLYLYDNKITKIENlEFLTNLTHLY---LQNNQIEKIEN--LENLVNLKKLYLGGNRI 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  512 KTVEqssfdnntklqairldgnyltdiaGLfTKLPNLLWLNISDNHLevfdyaliPTGLQWLdihankitelgnyFEIES 591
Cdd:cd21340     81 SVVE------------------------GL-ENLTNLEELHIENQRL--------PPGEKLT-------------FDPRS 114
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1899709811  592 QLALS----TIDASSNQLTEITGSAIPNSVELLYLNDNLISKVQ--SYTFFKKPNLTRVDLFGNKITT 653
Cdd:cd21340    115 LAALSnslrVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDLTGNPVCK 182
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
93-366 1.76e-08

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 57.75  E-value: 1.76e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811   93 FKQLTKLHSLSIEYCkiaNLSEGSFQGL-------KQLTNLTLRTHNTDWSSISLDIAPQVFNSeLSKLQRLDLSQNNmw 165
Cdd:cd00116     19 LPKLLCLQVLRLEGN---TLGEEAAKALasalrpqPSLKELCLSLNETGRIPRGLQSLLQGLTK-GCGLQELDLSDNA-- 92
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  166 SVPDGfiCPL-------SRLTYLNLTHNRLRDLSVFHFSASLstrlsKKCGSSIVTLDLSHNTIDNLPPA----IFSGLG 234
Cdd:cd00116     93 LGPDG--CGVlesllrsSSLQELKLNNNGLGDRGLRLLAKGL-----KDLPPALEKLVLGRNRLEGASCEalakALRANR 165
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  235 KLTDLRLQSNGLNyiaDRAFEGLVslsrleislnrltnlppELFSEAKHIKEIYLQNNSLN----VLAPGIFSDLKQLLV 310
Cdd:cd00116    166 DLKELNLANNGIG---DAGIRALA-----------------EGLKANCNLEVLDLNNNGLTdegaSALAETLASLKSLEV 225
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1899709811  311 LDLSNNELTSEWI---NPATFRGLTKLILLDLSNNKI----SKLEPTIFRDLTSLQVLRMQEN 366
Cdd:cd00116    226 LNLGDNNLTDAGAaalASALLSPNISLLTLSLSCNDItddgAKDLAEVLAEKESLLELDLRGN 288
LRR_8 pfam13855
Leucine rich repeat;
476-535 2.84e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 51.37  E-value: 2.84e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  476 HLYGLRLTENNIEIIRRGTFEAMKSLHILNLSQNRLKTVEQSSFDNNTKLQAIRLDGNYL 535
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
796-851 3.39e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 51.37  E-value: 3.39e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1899709811  796 IYLDGNNFRSLGSHAFLGRKRLKILFLNGSSVETVSNRTFYGLKELEILQLDHNLL 851
Cdd:pfam13855    6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
157-417 3.56e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 58.17  E-value: 3.56e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  157 LDLSQNNMWSVPD---GFICPLS----RLTYLNLThnrLRD-LSVFHFSASLSTRLSKKCGSSIVTLDLSHNTIDNLPPA 228
Cdd:PRK15370   204 LILDNNELKSLPEnlqGNIKTLYansnQLTSIPAT---LPDtIQEMELSINRITELPERLPSALQSLDLFHNKISCLPEN 280
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  229 IfsglgkltdlrlqSNGLNYiadrafeglvslsrLEISLNRLTNLPPELFSEakhIKEIYLQNNSLNVLAPGIFSDLKql 308
Cdd:PRK15370   281 L-------------PEELRY--------------LSVYDNSIRTLPAHLPSG---ITHLNVQSNSLTALPETLPPGLK-- 328
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  309 lVLDLSNNELTS--EWINPAtfrgltkLILLDLSNNKISKLEPTIFRDLTSLQVLRmqeNFIESIAENTfleLTALHTVI 386
Cdd:PRK15370   329 -TLEAGENALTSlpASLPPE-------LQVLDVSKNQITVLPETLPPTITTLDVSR---NALTNLPENL---PAALQIMQ 394
                          250       260       270
                   ....*....|....*....|....*....|....*
gi 1899709811  387 LSNNRLS----TVDHFTFSGLKSLTLLsLDYNRIS 417
Cdd:PRK15370   395 ASRNNLVrlpeSLPHFRGEGPQPTRII-VEYNPFS 428
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
794-919 3.60e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 57.25  E-value: 3.60e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  794 TQIYLDGNNFRSLGShAFLGRKRLKILFLNGSSVETVSNrTFYGLKELEILQLDHNLLTALnGFEFEGLDSLKELFLQYN 873
Cdd:COG4886    139 KELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGN 215
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1899709811  874 RIAQIANhTFDHLHGLKILRLDHNRIVEFNVWHLPKQLNDIRLAFN 919
Cdd:COG4886    216 QLTDLPE-PLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNN 260
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
794-920 4.32e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 57.25  E-value: 4.32e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  794 TQIYLDGNNFRSLGShAFLGRKRLKILFLNGSSVETVSNrTFYGLKELEILQLDHNLLTALnGFEFEGLDSLKELFLQYN 873
Cdd:COG4886    162 KSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNN 238
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1899709811  874 RIAQIANhtFDHLHGLKILRLDHNRIVEFNVWHLPKQLNDIRLAFNP 920
Cdd:COG4886    239 QLTDLPE--LGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQ 283
LRR_8 pfam13855
Leucine rich repeat;
500-558 1.26e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.83  E-value: 1.26e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  500 SLHILNLSQNRLKTVEQSSFDNNTKLQAIRLDGNYLTDI-AGLFTKLPNLLWLNISDNHL 558
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
309-596 2.37e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 54.28  E-value: 2.37e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  309 LVLDLSNNEL-TSEWINpaTFRGLTKLILLDLSNNKISKLE----PTIFRDLTSLQVLRMQENFIESIAENTFLELTALh 383
Cdd:cd00116      1 LQLSLKGELLkTERATE--LLPKLLCLQVLRLEGNTLGEEAakalASALRPQPSLKELCLSLNETGRIPRGLQSLLQGL- 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  384 tviLSNNRLSTVDHFT--FSGLKSLTLlsldynrisridrQALRNHSTLQELHLNGNKLLQ-----VPDALYDVPL-LRT 455
Cdd:cd00116     78 ---TKGCGLQELDLSDnaLGPDGCGVL-------------ESLLRSSSLQELKLNNNGLGDrglrlLAKGLKDLPPaLEK 141
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  456 LDLGEN---HISSIDNAS-FRHMAHLYGLRLTENNI--EIIRRgTFEAMKS---LHILNLSQNRLkTVEQSS-----FDN 521
Cdd:cd00116    142 LVLGRNrleGASCEALAKaLRANRDLKELNLANNGIgdAGIRA-LAEGLKAncnLEVLDLNNNGL-TDEGASalaetLAS 219
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  522 NTKLQAIRLDGNYLTD--IA----GLFTKLPNLLWLNISDNHLE----------VFDYALiptgLQWLDIHANKITELGN 585
Cdd:cd00116    220 LKSLEVLNLGDNNLTDagAAalasALLSPNISLLTLSLSCNDITddgakdlaevLAEKES----LLELDLRGNKFGEEGA 295
                          330
                   ....*....|.
gi 1899709811  586 YFEIESQLALS 596
Cdd:cd00116    296 QLLAESLLEPG 306
LRR_8 pfam13855
Leucine rich repeat;
210-270 2.50e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.67  E-value: 2.50e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1899709811  210 SSIVTLDLSHNTIDNLPPAIFSGLGKLTDLRLQSNGLNYIADRAFEGLVSLSRLEISLNRL 270
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
337-416 4.37e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.29  E-value: 4.37e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  337 LDLSNNKISKLEPTIFRDLTSLQVLrmqenfiesiaentfleltalhtvILSNNRLSTVDHFTFSGLKSLTLLSLDYNRI 416
Cdd:pfam13855    6 LDLSNNRLTSLDDGAFKGLSNLKVL------------------------DLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
409-653 2.07e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 51.20  E-value: 2.07e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  409 LSLDYNRISRID-RQALRNHSTLQELHLNGNKL-----LQVPDALYDVPLLRTLDLGENHISSIDNA------SFRHMAH 476
Cdd:cd00116      3 LSLKGELLKTERaTELLPKLLCLQVLRLEGNTLgeeaaKALASALRPQPSLKELCLSLNETGRIPRGlqsllqGLTKGCG 82
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  477 LYGLRLTENNIEIIRRGTFEAM---KSLHILNLSQNRL-----KTVEQSSFDNNTKLQAIRLDGNYLT-----DIAGLFT 543
Cdd:cd00116     83 LQELDLSDNALGPDGCGVLESLlrsSSLQELKLNNNGLgdrglRLLAKGLKDLPPALEKLVLGRNRLEgasceALAKALR 162
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  544 KLPNLLWLNISDNHLEVFDYALI------PTGLQWLDIHANKITELGNYF---EIESQLALSTIDASSNQLTEITGSAIP 614
Cdd:cd00116    163 ANRDLKELNLANNGIGDAGIRALaeglkaNCNLEVLDLNNNGLTDEGASAlaeTLASLKSLEVLNLGDNNLTDAGAAALA 242
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|
gi 1899709811  615 N-------SVELLYLNDNLISKVQSYTF----FKKPNLTRVDLFGNKITT 653
Cdd:cd00116    243 SallspniSLLTLSLSCNDITDDGAKDLaevlAEKESLLELDLRGNKFGE 292
LRR_8 pfam13855
Leucine rich repeat;
405-463 2.71e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.98  E-value: 2.71e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  405 SLTLLSLDYNRISRIDRQALRNHSTLQELHLNGNKLLQV-PDALYDVPLLRTLDLGENHI 463
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
428-487 2.87e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.98  E-value: 2.87e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1899709811  428 STLQELHLNGNKLLQV-PDALYDVPLLRTLDLGENHISSIDNASFRHMAHLYGLRLTENNI 487
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
235-294 4.25e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.21  E-value: 4.25e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  235 KLTDLRLQSNGLNYIADRAFEGLVSLSRLEISLNRLTNLPPELFSEAKHIKEIYLQNNSL 294
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
88-463 5.75e-06

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 50.56  E-value: 5.75e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811   88 LSPGSFKQLTKLHSLSIEYCKIANLSEGSFQGLKQLtnltLRTHNTDWSSIS------LDIAPQVFNSELSKLQRLDLSQ 161
Cdd:COG5238     13 EELLSANPATTEQSELTKRATIVNLRSYHLHGGAIL----LARYLQSRSSITqylrfeGQGDPGLNPVALEKAAEAFPTQ 88
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  162 nnMWSVPDGFICPLSRLTYLNLT---HNRLRDLSVFHFSASLSTRlskkcGSSIVTLDLSHNTIDNLPPAIFSGLGKLTD 238
Cdd:COG5238     89 --LLVVDWEGAEEVSPVALAETAtavATPPPDLRRIMAKTLEDSL-----ILYLALPRRINLIQVLKDPLGGNAVHLLGL 161
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  239 LRLQSnGLNYIADRAFEGLVSLSRLEISLNRLTNLPPELFSEA----KHIKEIYLQNNSLNVL-APGIFSDL---KQLLV 310
Cdd:COG5238    162 AARLG-LLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEAltqnTTVTTLWLKRNPIGDEgAEILAEALkgnKSLTT 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  311 LDLSNNELTSEWINpATFRGL---TKLILLDLSNNKIS----KLEPTIFRDLTSLQVLRMQENFI-----ESIAENtfLE 378
Cdd:COG5238    241 LDLSNNQIGDEGVI-ALAEALknnTTVETLYLSGNQIGaegaIALAKALQGNTTLTSLDLSVNRIgdegaIALAEG--LQ 317
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  379 LTA-LHTVILSNNRLSTVD-HFTFSGLK---SLTLLSLDYNRISRIDR----QALRNHSTLQELHLNGNKL-----LQVP 444
Cdd:COG5238    318 GNKtLHTLNLAYNGIGAQGaIALAKALQentTLHSLDLSDNQIGDEGAialaKYLEGNTTLRELNLGKNNIgkqgaEALI 397
                          410
                   ....*....|....*....
gi 1899709811  445 DALyDVPLLRTLDLGENHI 463
Cdd:COG5238    398 DAL-QTNRLHTLILDGNLI 415
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
794-899 8.64e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 48.24  E-value: 8.64e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  794 TQIYLDGNNFRSLGSHAFLgrKRLKILFLNGSSVETVSNrtFYGLKELEILQLDHNLLTALNGFEfeGLDSLKELFLQYN 873
Cdd:cd21340      5 THLYLNDKNITKIDNLSLC--KNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIENLE--NLVNLKKLYLGGN 78
                           90       100
                   ....*....|....*....|....*.
gi 1899709811  874 RIAQIANhtFDHLHGLKILRLDHNRI 899
Cdd:cd21340     79 RISVVEG--LENLTNLEELHIENQRL 102
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
391-611 2.46e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 48.92  E-value: 2.46e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  391 RLSTVDHFTfsgLKSLTLLSLDYNRISRIDRQAlrnHSTLQELHLNGNKLLQVPDALYDVplLRTLDLGENHISSIDNas 470
Cdd:PRK15370   189 GLTTIPACI---PEQITTLILDNNELKSLPENL---QGNIKTLYANSNQLTSIPATLPDT--IQEMELSINRITELPE-- 258
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  471 fRHMAHLYGLRLTENNIEIIRRGTFEAMKSLHILNlsqNRLKT---------VEQSSFDNN---------TKLQAIRLDG 532
Cdd:PRK15370   259 -RLPSALQSLDLFHNKISCLPENLPEELRYLSVYD---NSIRTlpahlpsgiTHLNVQSNSltalpetlpPGLKTLEAGE 334
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1899709811  533 NYLTDIAGLFTklPNLLWLNISDNHLEVFDYALIPTgLQWLDIHANKITELGNYFEIesqlALSTIDASSNQLTEITGS 611
Cdd:PRK15370   335 NALTSLPASLP--PELQVLDVSKNQITVLPETLPPT-ITTLDVSRNALTNLPENLPA----ALQIMQASRNNLVRLPES 406
PLN03150 PLN03150
hypothetical protein; Provisional
289-368 8.14e-05

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 47.12  E-value: 8.14e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  289 LQNNSLNVLAPGIFSDLKQLLVLDLSNNELTSEWinPATFRGLTKLILLDLSNNKISKLEPTIFRDLTSLQVLRMQENFI 368
Cdd:PLN03150   425 LDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNI--PPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSL 502
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
794-920 1.38e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 44.78  E-value: 1.38e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  794 TQIYLDGNNFRSLGShaFLGRKRLKILFLNGSSVETVSNrtFYGLKELEILQLDHNLLTALNGFEFEG------LDSLKE 867
Cdd:cd21340     49 THLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVVEG--LENLTNLEELHIENQRLPPGEKLTFDPrslaalSNSLRV 124
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1899709811  868 LFLQYNRIAQIANhtFDHLHGLKILRLDHNRIVEFN--VWHLPK--QLNDIRLAFNP 920
Cdd:cd21340    125 LNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEelLDLLSSwpSLRELDLTGNP 179
LRR_9 pfam14580
Leucine-rich repeat;
337-417 1.77e-04

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 43.60  E-value: 1.77e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  337 LDLSNNKISKLEPtiFRDLTSLQVLRMQENFIESIAENTFLELTALHTVILSNNRL-STVDHFTFSGLKSLTLLSLDYNR 415
Cdd:pfam14580   47 IDFSDNEIRKLDG--FPLLRRLKTLLLNNNRICRIGEGLGEALPNLTELILTNNNLqELGDLDPLASLKKLTFLSLLRNP 124

                   ..
gi 1899709811  416 IS 417
Cdd:pfam14580  125 VT 126
LRR_8 pfam13855
Leucine rich repeat;
523-580 2.04e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.59  E-value: 2.04e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1899709811  523 TKLQAIRLDGNYLTDI-AGLFTKLPNLLWLNISDNHLEVFDYALI--PTGLQWLDIHANKI 580
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPGAFsgLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
374-455 4.63e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 44.42  E-value: 4.63e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  374 NTFLELTALHTVILSNNRLSTVDHFTFSGLKSLTLLSLDYNRISRIDRQALRNHSTLQELHLNGNKLL-QVPDALYDVPL 452
Cdd:PLN03150   436 NDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSgRVPAALGGRLL 515

                   ...
gi 1899709811  453 LRT 455
Cdd:PLN03150   516 HRA 518
LRR_8 pfam13855
Leucine rich repeat;
122-188 5.18e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.43  E-value: 5.18e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1899709811  122 QLTNLTLrthntdWSSISLDIAPQVFNSeLSKLQRLDLSQNNMWSVPDGFICPLSRLTYLNLTHNRL 188
Cdd:pfam13855    2 NLRSLDL------SNNRLTSLDDGAFKG-LSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
368-584 6.96e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 43.63  E-value: 6.96e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  368 IESIAENTFLELT-ALHTVILSNNRLSTVDHFTFSGLK--SLTLLSLDYNRISRIDRQALRNH----STLQELHLNGNKL 440
Cdd:COG5238    141 INLIQVLKDPLGGnAVHLLGLAARLGLLAAISMAKALQnnSVETVYLGCNQIGDEGIEELAEAltqnTTVTTLWLKRNPI 220
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  441 --LQVP---DALYDVPLLRTLDLGENHISS----------IDNASFRHMaHLYGLRLTENNIEIIRRgTFEAMKSLHILN 505
Cdd:COG5238    221 gdEGAEilaEALKGNKSLTTLDLSNNQIGDegvialaealKNNTTVETL-YLSGNQIGAEGAIALAK-ALQGNTTLTSLD 298
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  506 LSQNRLK----TVEQSSFDNNTKLQAIRLDGNYLTD-----IAGLFTKLPNLLWLNISDNHLEVFDYALI------PTGL 570
Cdd:COG5238    299 LSVNRIGdegaIALAEGLQGNKTLHTLNLAYNGIGAqgaiaLAKALQENTTLHSLDLSDNQIGDEGAIALakylegNTTL 378
                          250
                   ....*....|....
gi 1899709811  571 QWLDIHANKITELG 584
Cdd:COG5238    379 RELNLGKNNIGKQG 392
LRR_8 pfam13855
Leucine rich repeat;
152-220 7.45e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.04  E-value: 7.45e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1899709811  152 SKLQRLDLSQNNMWSVPDGFICPLSRLTYLNLTHNRLRDLS--VFHFSASLStrlskkcgssivTLDLSHN 220
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSpgAFSGLPSLR------------YLDLSGN 59
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
831-899 7.92e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 43.38  E-value: 7.92e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1899709811  831 SNRTFYGLKELEILQLDHNLLTALnGFEFEGLDSLKELFLQYNRIAQIANhTFDHLHGLKILRLDHNRI 899
Cdd:COG4886    105 GNEELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQL 171
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
408-659 1.37e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 42.85  E-value: 1.37e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  408 LLSLDYNRISR----IDRQALRNHStLQELHLNGNKLLQ-----VPDALYDVPLLRTLDLGENHISsiDNASFRHMAHLY 478
Cdd:COG5238    157 HLLGLAARLGLlaaiSMAKALQNNS-VETVYLGCNQIGDegieeLAEALTQNTTVTTLWLKRNPIG--DEGAEILAEALK 233
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  479 GLrltennieiirrgtfeamKSLHILNLSQNRLKTVEQSSF----DNNTKLQAIRLDGNYLTD-----IAGLFTKLPNLL 549
Cdd:COG5238    234 GN------------------KSLTTLDLSNNQIGDEGVIALaealKNNTTVETLYLSGNQIGAegaiaLAKALQGNTTLT 295
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  550 WLNISDNHLEVFDYALIPTGLQW------LDIHANKITELGNYF---EIESQLALSTIDASSNQLTEITGSAIPNsvell 620
Cdd:COG5238    296 SLDLSVNRIGDEGAIALAEGLQGnktlhtLNLAYNGIGAQGAIAlakALQENTTLHSLDLSDNQIGDEGAIALAK----- 370
                          250       260       270
                   ....*....|....*....|....*....|....*....
gi 1899709811  621 YLNDNliskvqsytffkkPNLTRVDLFGNKITTLDPNAL 659
Cdd:COG5238    371 YLEGN-------------TTLRELNLGKNNIGKQGAEAL 396
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
91-226 3.22e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.54  E-value: 3.22e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811   91 GSFKQLTKLHslsIEYCKIANLsEGsFQGLKQLTNLTLRTHNTDwSSISLDIAPQVFNSELSKLQRLDLSQNNMWSVPDg 170
Cdd:cd21340     65 ENLVNLKKLY---LGGNRISVV-EG-LENLTNLEELHIENQRLP-PGEKLTFDPRSLAALSNSLRVLNISGNNIDSLEP- 137
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1899709811  171 fICPLSRLTYLNLTHNRLRDLSVFhfsaslsTRLSKKCgSSIVTLDLSHNTIDNLP 226
Cdd:cd21340    138 -LAPLRNLEQLDASNNQISDLEEL-------LDLLSSW-PSLRELDLTGNPVCKKP 184
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
235-358 3.28e-03

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 39.07  E-value: 3.28e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  235 KLTDLRLqSNGLNYIADRAFEGLVSLSRLEISlNRLTNLPPELFSEAKhIKEIYLqNNSLNVLAPGIFSDLKQLLVLDLS 314
Cdd:pfam13306   12 SLTSITI-PSSLTSIGEYAFSNCTSLKSITLP-SSLTSIGSYAFYNCS-LTSITI-PSSLTSIGEYAFSNCSNLKSITLP 87
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1899709811  315 NNeLTSewINPATFRGlTKLILLDLSNNkISKLEPTIFRDLTSL 358
Cdd:pfam13306   88 SN-LTS--IGSYAFSN-CSLKSITIPSS-VTTIGSYAFSNCSNL 126
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
794-922 3.31e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 41.46  E-value: 3.31e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  794 TQIYLDGNNFRSLgSHAFLGRKRLKILFLNGSSVETVSNrtFYGLKELEILQLDHNLLTALNgfEFEGLDSLKELFLQYN 873
Cdd:COG4886    208 EELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNN 282
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1899709811  874 RIAQIANHTFDHLHGLKILRLDHNRIVEFNVWHLPKQLNDIRLAFNPWS 922
Cdd:COG4886    283 QLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLK 331
PLN03150 PLN03150
hypothetical protein; Provisional
275-345 4.62e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 41.34  E-value: 4.62e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1899709811  275 PELFSEAKHIKEIYLQNNSLNVLAPGIFSDLKQLLVLDLSNNELTSEWinPATFRGLTKLILLDLSNNKIS 345
Cdd:PLN03150   435 PNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSI--PESLGQLTSLRILNLNGNSLS 503
LRR_8 pfam13855
Leucine rich repeat;
864-920 5.03e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.73  E-value: 5.03e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  864 SLKELFLQYNRIAQIANHTFDHLHGLKILRLDHNRIVEFNV---WHLPKqLNDIRLAFNP 920
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPgafSGLPS-LRYLDLSGNR 60
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
323-430 6.18e-03

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 38.29  E-value: 6.18e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899709811  323 INPATFRGLTKLILLDLSNNkISKLEPTIFRDlTSLQVLRMQENfIESIAENTFLELTALHTVILSNNrLSTVDHFTFSG 402
Cdd:pfam13306   25 IGEYAFSNCTSLKSITLPSS-LTSIGSYAFYN-CSLTSITIPSS-LTSIGEYAFSNCSNLKSITLPSN-LTSIGSYAFSN 100
                           90       100       110
                   ....*....|....*....|....*....|
gi 1899709811  403 --LKSLTLLSLdynrISRIDRQALRNHSTL 430
Cdd:pfam13306  101 csLKSITIPSS----VTTIGSYAFSNCSNL 126
LRR_8 pfam13855
Leucine rich repeat;
616-660 9.45e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.96  E-value: 9.45e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1899709811  616 SVELLYLNDNLISKVQSYTFFKKPNLTRVDLFGNKITTLDPNALR 660
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFS 46
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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