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Conserved domains on  [gi|2007683847|ref|XP_039973669|]
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Krueppel-like factor 10 isoform X2 [Xiphias gladius]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KLF10_N cd21572
N-terminal domain of Kruppel-like factor 10; Kruppel-like factor 10 (KLF10; also known as ...
 1-354 6.28e-106

N-terminal domain of Kruppel-like factor 10; Kruppel-like factor 10 (KLF10; also known as Krueppel-like factor 10; early growth response(EGR)-alpha/EGRA; TGFbeta inducible early gene-1/TIEG1) is a protein that in humans is encoded by the KLF10 gene. KLF10 was first identified in human osteoblasts and plays a role in mediating estrogen (E2) signaling in bone and skeletal homeostasis and a regulatory role in tumor formation and metastasis. It may also play a role in adipocyte differentiation and adipose tissue function. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved a-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF10 belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF10.


:

Pssm-ID: 409241 [Multi-domain]  Cd Length: 245  Bit Score: 315.00  E-value: 6.28e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2007683847   1 MEAVEALMSMTKHWKSRNFRLRHFRPLTPSSDCSEDDSVPLGSGVLQDSHLCMTPPYSPPHCEATHPPSAATLHQlalag 80
Cdd:cd21572     6 MEAVEALMSMTKHWKTRSFRLRHFRPLTPSSDSSEDDDLPSPADFHDSPPFCMTPPYSPPHFEATHPPSAATLHP----- 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2007683847  81 sPTWQPALETHLHTQTAASQQRFQCTSVIRHTADGRHCCCSVHPvskedrlgrvhtkdskrdlnsedgqktrdseriiim 160
Cdd:cd21572    81 -PAAQPPEEQHLSAETAASQQRFQCTSVIRHTADAQPCSCSSCP------------------------------------ 123

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2007683847 161 hsdsraatpqkpltatlpnvaedsqtqmslsgpddesNTPQSCASAPAGVNGVSPVPVYCQFLSVSSLSAAVVQKPVTAS 240
Cdd:cd21572   124 -------------------------------------SSPSVVPSVPAGVAGVSPVPVYCQILPVSSSSTTVVAAQAPLP 166

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2007683847 241 esqrqhtpqcvsaasaastlhthqqqqhkqqlallQPQTQAASSAQVFLLGGQVAKGPLMLLVPQPAIPTVYVQPALVTS 320
Cdd:cd21572   167 -----------------------------------QPQQQAASPAQVFLMGGQVPKGPVMFLVPQPVVPTLYVQPTLVTP 211

                         330       340       350
                  ....*....|....*....|....*....|....
gi 2007683847 321 GGTKLPAIAPAPGRTLLEQRQSPLQPELSRVRSH 354
Cdd:cd21572   212 GGTKLAAIAPAPGHTPSEQRKSPPQPEVSRVRSH 245
zf-H2C2_2 pfam13465
Zinc-finger double domain;
370-397 2.64e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.64e-04
                          10        20
                  ....*....|....*....|....*...
gi 2007683847 370 HLKAHMRTHTGEKPFRCKweGCERRFAR 397
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCP--ECGKSFKS 26
COG5048 super family cl34881
FOG: Zn-finger [General function prediction only];
352-437 7.31e-03

FOG: Zn-finger [General function prediction only];


The actual alignment was detected with superfamily member COG5048:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.52  E-value: 7.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2007683847 352 RSHVCPHEVCRKTYFKSSHLKAHMRTHTGEKPFRCKWEGCERRF-----ARSDELSRHRRTHTGEKKFVCPM--CLSRFM 424
Cdd:COG5048   320 KPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFspllnNEPPQSLQQYKDLKNDKKSETLSnsCIRNFK 399

                          90
                  ....*....|...
gi 2007683847 425 RSDHLAKHTRRHL 437
Cdd:COG5048   400 RDSNLSLHIITHL 412
 
Name Accession Description Interval E-value
KLF10_N cd21572
N-terminal domain of Kruppel-like factor 10; Kruppel-like factor 10 (KLF10; also known as ...
 1-354 6.28e-106

N-terminal domain of Kruppel-like factor 10; Kruppel-like factor 10 (KLF10; also known as Krueppel-like factor 10; early growth response(EGR)-alpha/EGRA; TGFbeta inducible early gene-1/TIEG1) is a protein that in humans is encoded by the KLF10 gene. KLF10 was first identified in human osteoblasts and plays a role in mediating estrogen (E2) signaling in bone and skeletal homeostasis and a regulatory role in tumor formation and metastasis. It may also play a role in adipocyte differentiation and adipose tissue function. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved a-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF10 belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF10.


Pssm-ID: 409241 [Multi-domain]  Cd Length: 245  Bit Score: 315.00  E-value: 6.28e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2007683847   1 MEAVEALMSMTKHWKSRNFRLRHFRPLTPSSDCSEDDSVPLGSGVLQDSHLCMTPPYSPPHCEATHPPSAATLHQlalag 80
Cdd:cd21572     6 MEAVEALMSMTKHWKTRSFRLRHFRPLTPSSDSSEDDDLPSPADFHDSPPFCMTPPYSPPHFEATHPPSAATLHP----- 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2007683847  81 sPTWQPALETHLHTQTAASQQRFQCTSVIRHTADGRHCCCSVHPvskedrlgrvhtkdskrdlnsedgqktrdseriiim 160
Cdd:cd21572    81 -PAAQPPEEQHLSAETAASQQRFQCTSVIRHTADAQPCSCSSCP------------------------------------ 123

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2007683847 161 hsdsraatpqkpltatlpnvaedsqtqmslsgpddesNTPQSCASAPAGVNGVSPVPVYCQFLSVSSLSAAVVQKPVTAS 240
Cdd:cd21572   124 -------------------------------------SSPSVVPSVPAGVAGVSPVPVYCQILPVSSSSTTVVAAQAPLP 166

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2007683847 241 esqrqhtpqcvsaasaastlhthqqqqhkqqlallQPQTQAASSAQVFLLGGQVAKGPLMLLVPQPAIPTVYVQPALVTS 320
Cdd:cd21572   167 -----------------------------------QPQQQAASPAQVFLMGGQVPKGPVMFLVPQPVVPTLYVQPTLVTP 211

                         330       340       350
                  ....*....|....*....|....*....|....
gi 2007683847 321 GGTKLPAIAPAPGRTLLEQRQSPLQPELSRVRSH 354
Cdd:cd21572   212 GGTKLAAIAPAPGHTPSEQRKSPPQPEVSRVRSH 245
zf-H2C2_2 pfam13465
Zinc-finger double domain;
370-397 2.64e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.64e-04
                          10        20
                  ....*....|....*....|....*...
gi 2007683847 370 HLKAHMRTHTGEKPFRCKweGCERRFAR 397
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCP--ECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
368-421 4.34e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.29  E-value: 4.34e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2007683847 368 SSHLKAHMRTHTGEKPFRCKWEGCERRFARSDELSRHRRTHTGEKKFVCPMCLS 421
Cdd:COG5048    46 LEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLP 99
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
352-437 7.31e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.52  E-value: 7.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2007683847 352 RSHVCPHEVCRKTYFKSSHLKAHMRTHTGEKPFRCKWEGCERRF-----ARSDELSRHRRTHTGEKKFVCPM--CLSRFM 424
Cdd:COG5048   320 KPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFspllnNEPPQSLQQYKDLKNDKKSETLSnsCIRNFK 399

                          90
                  ....*....|...
gi 2007683847 425 RSDHLAKHTRRHL 437
Cdd:COG5048   400 RDSNLSLHIITHL 412
 
Name Accession Description Interval E-value
KLF10_N cd21572
N-terminal domain of Kruppel-like factor 10; Kruppel-like factor 10 (KLF10; also known as ...
 1-354 6.28e-106

N-terminal domain of Kruppel-like factor 10; Kruppel-like factor 10 (KLF10; also known as Krueppel-like factor 10; early growth response(EGR)-alpha/EGRA; TGFbeta inducible early gene-1/TIEG1) is a protein that in humans is encoded by the KLF10 gene. KLF10 was first identified in human osteoblasts and plays a role in mediating estrogen (E2) signaling in bone and skeletal homeostasis and a regulatory role in tumor formation and metastasis. It may also play a role in adipocyte differentiation and adipose tissue function. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved a-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF10 belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF10.


Pssm-ID: 409241 [Multi-domain]  Cd Length: 245  Bit Score: 315.00  E-value: 6.28e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2007683847   1 MEAVEALMSMTKHWKSRNFRLRHFRPLTPSSDCSEDDSVPLGSGVLQDSHLCMTPPYSPPHCEATHPPSAATLHQlalag 80
Cdd:cd21572     6 MEAVEALMSMTKHWKTRSFRLRHFRPLTPSSDSSEDDDLPSPADFHDSPPFCMTPPYSPPHFEATHPPSAATLHP----- 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2007683847  81 sPTWQPALETHLHTQTAASQQRFQCTSVIRHTADGRHCCCSVHPvskedrlgrvhtkdskrdlnsedgqktrdseriiim 160
Cdd:cd21572    81 -PAAQPPEEQHLSAETAASQQRFQCTSVIRHTADAQPCSCSSCP------------------------------------ 123

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2007683847 161 hsdsraatpqkpltatlpnvaedsqtqmslsgpddesNTPQSCASAPAGVNGVSPVPVYCQFLSVSSLSAAVVQKPVTAS 240
Cdd:cd21572   124 -------------------------------------SSPSVVPSVPAGVAGVSPVPVYCQILPVSSSSTTVVAAQAPLP 166

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2007683847 241 esqrqhtpqcvsaasaastlhthqqqqhkqqlallQPQTQAASSAQVFLLGGQVAKGPLMLLVPQPAIPTVYVQPALVTS 320
Cdd:cd21572   167 -----------------------------------QPQQQAASPAQVFLMGGQVPKGPVMFLVPQPVVPTLYVQPTLVTP 211

                         330       340       350
                  ....*....|....*....|....*....|....
gi 2007683847 321 GGTKLPAIAPAPGRTLLEQRQSPLQPELSRVRSH 354
Cdd:cd21572   212 GGTKLAAIAPAPGHTPSEQRKSPPQPEVSRVRSH 245
KLF10_11_N cd21974
N-terminal domain of Kruppel-like factor (KLF) 10, KLF11, and similar proteins; This subfamily ...
 1-354 4.71e-85

N-terminal domain of Kruppel-like factor (KLF) 10, KLF11, and similar proteins; This subfamily is composed of Kruppel-like factor or Krueppel-like factor (KLF) 10, KLF11, and similar proteins. KLF10 was first identified in human osteoblasts and plays a role in mediating estrogen (E2) signaling in bone and skeletal homeostasis and a regulatory role in tumor formation and metastasis. KLF11 is involved in cell growth, apoptosis, cellular inflammation and differentiation, endometriosis, and cholesterol, prostaglandin, neurotransmitter, fat, and sugar metabolism. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved a-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF10/11 belong to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF10, KLF11, and similar proteins.


Pssm-ID: 409243 [Multi-domain]  Cd Length: 229  Bit Score: 260.64  E-value: 4.71e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2007683847   1 MEAVEALMSMTKHWKSRNFRLRHFRPLTPSSDCSEDDSVPLGSGVLQD-SHLCMTPPYSPPHCEATHPPSAATLHQLAla 79
Cdd:cd21974     5 LEAVEALVSMSSWWKRRQKRLRKPRPLTPSSDSSDEDDAPESPKDFHSlSSLCMTPPYSPPFFEASHSPSVASLHPPS-- 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2007683847  80 gSPTWQPALETHLHTQTAASQQRFQCTSVIRHTADgrhcccsvhpvskedrlgrvhtkdskrdlnsedgqktrdseriii 159
Cdd:cd21974    83 -AASSQPPPEPESSEPPAASPQRAQATSVIRHTAD--------------------------------------------- 116

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2007683847 160 mhsdsraatpqkpltatlpnvaedsqtqmslsgpddesntpqscasapagVNGVSPVPVYCQFLSVSSLSAAVVQKPVTA 239
Cdd:cd21974   117 --------------------------------------------------PVPVSPPPVLCQMLPVSSSSGVIVAFLKAP 146

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2007683847 240 SESQRQhtpqcvsaasaastlhthqqqqhkqqlallqPQTQAASSAQVFLLGGQVAKGPLMLLVPQPAIPTVYVQPALVT 319
Cdd:cd21974   147 QQPSPQ-------------------------------PQKPALPQPQVVLVGGQVPQGPVMLVVPQPAVPQPYVQPTVVT 195

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 2007683847 320 SGGTKLPAIAPAPGRTLLEQRqSPLQPELSRVRSH 354
Cdd:cd21974   196 PGGTKLLPIAPAPGFIPSGQS-SAPQPDFSRRRNH 229
KLF11_N cd21584
N-terminal domain of Kruppel-like factor 11; Kruppel-like factor 11 (KLF11; also known as ...
 1-332 6.67e-11

N-terminal domain of Kruppel-like factor 11; Kruppel-like factor 11 (KLF11; also known as Krueppel-like factor 11; Fetal Kruppel-like factor-1/FKLF-1; maturity-onset diabetes of the young 7/MODY7; TGFbeta Inducible Early Growth Response 2/TIEG2) is a protein that in humans is encoded by the KLF11 gene. KLF11 is involved in cell growth, apoptosis, cellular inflammation and differentiation, endometriosis, and cholesterol, prostaglandin, neurotransmitter, fat, and sugar metabolism. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved a-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF11 belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF11.


Pssm-ID: 409242 [Multi-domain]  Cd Length: 217  Bit Score: 61.93  E-value: 6.67e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2007683847   1 MEAVEALMSMTKhWKSRNFR--LRHFRPLTPSSDCseDDSVPLGSGVLQD-------SHLCMTPPYSPPHCEAThppsaa 71
Cdd:cd21584     6 LEAVEALVCMSS-WGQRSQKgdLLKIRPLTPASDS--CDSLTLHPAAPELpkdfhslSSLCMTPPHSPSFAEPS------ 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2007683847  72 tlhqlalagsptwqpalethlhTQTAASQQRFQCTSVIRHTADgrhcccSVHPVSkedrlgrvhtkdskrdlnsedgqkt 151
Cdd:cd21584    77 ----------------------TTAPPPPCRAMATSVIRHTAD------SSPPVP------------------------- 103

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2007683847 152 rdseriiimhsdsraatpqkpltatlpnvaedsqtqmslsgpddesntpqscasapagvngVSPVPVYCQFLSVSS---L 228
Cdd:cd21584   104 -------------------------------------------------------------VPSPPVLCQMIPVSGqsgM 122

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2007683847 229 SAAVVQKPVTASESQRqhtpqcvsaasaastlhthqqqqhkqqlallQPQTQAASSAQVFLLGGQVAKGPLMLLVPQPAI 308
Cdd:cd21584   123 ISAFLQPPALSAGTVK-------------------------------PILPQTAPASQPLLVGSPVPQGTVMLVLPQASV 171

                         330       340
                  ....*....|....*....|....*
gi 2007683847 309 P-TVYVQPALVTSGGTKLPAIAPAP 332
Cdd:cd21584   172 PqPPQCPQTVMTLGNTKLLPLAPAP 196
zf-H2C2_2 pfam13465
Zinc-finger double domain;
370-397 2.64e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.64e-04
                          10        20
                  ....*....|....*....|....*...
gi 2007683847 370 HLKAHMRTHTGEKPFRCKweGCERRFAR 397
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCP--ECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
368-421 4.34e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.29  E-value: 4.34e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2007683847 368 SSHLKAHMRTHTGEKPFRCKWEGCERRFARSDELSRHRRTHTGEKKFVCPMCLS 421
Cdd:COG5048    46 LEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLP 99
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
352-437 7.31e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.52  E-value: 7.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2007683847 352 RSHVCPHEVCRKTYFKSSHLKAHMRTHTGEKPFRCKWEGCERRF-----ARSDELSRHRRTHTGEKKFVCPM--CLSRFM 424
Cdd:COG5048   320 KPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFspllnNEPPQSLQQYKDLKNDKKSETLSnsCIRNFK 399

                          90
                  ....*....|...
gi 2007683847 425 RSDHLAKHTRRHL 437
Cdd:COG5048   400 RDSNLSLHIITHL 412
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
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