NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2019537954|ref|XP_040293272|]
View 

myb-related protein B [Bufo bufo]

Protein Classification

myb-related protein( domain architecture ID 13851054)

myb-related protein contains a SANT (SWI3, ADA2, N-CoR and TFIIIB)/Myb-like DNA-binding domain, binds DNA and functions as a transcription factor, such as human myb-related protein A that specifically recognizes the sequence 5'-YAAC[GT]G-3'

CATH:  1.20.58.1880
Gene Ontology:  GO:0006355|GO:0003700|GO:0003677
PubMed:  8882580
SCOP:  4000317

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Cmyb_C pfam09316
C-myb, C-terminal; Members of this family are predominantly found in the proto-oncogene c-myb ...
 410-553 1.39e-54

C-myb, C-terminal; Members of this family are predominantly found in the proto-oncogene c-myb and the viral transforming protein myb. Truncation of the domain results in 'activation' of c-myb and subsequent tumourigenesis.


:

Pssm-ID: 462753  Cd Length: 157  Bit Score: 184.49  E-value: 1.39e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2019537954 410 FSPSQFLNFWSKHDALELENPSLTSTPVCSQKVVVTTPLHRDKTPLLQK-NSAFVTPN-HKFMGDNAPHTPTPFKNALE- 486
Cdd:pfam09316   1 FSPSQFLNESSGQENLPLENPTLTSTPVCGQKVFLTTPLHKDQTPKYQKeNTGFRTPNiRRSILETTPRTPTPFKNALAa 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2019537954 487 ---KFGSLRPLPPTP-HLEEDLKEVLRNESGIELVIVDESKHERPKRKPGHsHSPIKKVRKSLALDVVDKE 553
Cdd:pfam09316  81 qekKYGPLKPLPQTPaHLEEDLQEVLKSEIGSDIEIGEDEKPWKQKIKQEH-RSPNKKVRKSLWLDDWDKE 150
PLN03091 super family cl33633
hypothetical protein; Provisional
 83-188 4.03e-29

hypothetical protein; Provisional


The actual alignment was detected with superfamily member PLN03091:

Pssm-ID: 215570 [Multi-domain]  Cd Length: 459  Bit Score: 121.62  E-value: 4.03e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2019537954  83 KGPWTKEEDEKVIELVKKYGTKHWTLIAKQLK-GRLGKQCRERWHNHLNPEVKKSSWTEEEDRIICQAHKVLGNRWAEIA 161
Cdd:PLN03091   14 KGLWSPEEDEKLLRHITKYGHGCWSSVPKQAGlQRCGKSCRLRWINYLRPDLKRGTFSQQEENLIIELHAVLGNRWSQIA 93

                          90       100
                  ....*....|....*....|....*..
gi 2019537954 162 KLLPGRTDNAVKNHWNSTIKRKVETGG 188
Cdd:PLN03091   94 AQLPGRTDNEIKNLWNSCLKKKLRQRG 120
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 34-94 3.75e-20

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


:

Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 84.28  E-value: 3.75e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2019537954  34 WTHEEDEVLRALVKKYGpGEWKQIASHMLNRTEQQCQQRWLRVLHPDRVKGPWTKEEDEKV 94
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYG-NDWKQIAKELGRRTPKQCFDRWRRKLNPKISRGPWSKEEDQRL 60
 
Name Accession Description Interval E-value
Cmyb_C pfam09316
C-myb, C-terminal; Members of this family are predominantly found in the proto-oncogene c-myb ...
 410-553 1.39e-54

C-myb, C-terminal; Members of this family are predominantly found in the proto-oncogene c-myb and the viral transforming protein myb. Truncation of the domain results in 'activation' of c-myb and subsequent tumourigenesis.


Pssm-ID: 462753  Cd Length: 157  Bit Score: 184.49  E-value: 1.39e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2019537954 410 FSPSQFLNFWSKHDALELENPSLTSTPVCSQKVVVTTPLHRDKTPLLQK-NSAFVTPN-HKFMGDNAPHTPTPFKNALE- 486
Cdd:pfam09316   1 FSPSQFLNESSGQENLPLENPTLTSTPVCGQKVFLTTPLHKDQTPKYQKeNTGFRTPNiRRSILETTPRTPTPFKNALAa 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2019537954 487 ---KFGSLRPLPPTP-HLEEDLKEVLRNESGIELVIVDESKHERPKRKPGHsHSPIKKVRKSLALDVVDKE 553
Cdd:pfam09316  81 qekKYGPLKPLPQTPaHLEEDLQEVLKSEIGSDIEIGEDEKPWKQKIKQEH-RSPNKKVRKSLWLDDWDKE 150
PLN03091 PLN03091
hypothetical protein; Provisional
 83-188 4.03e-29

hypothetical protein; Provisional


Pssm-ID: 215570 [Multi-domain]  Cd Length: 459  Bit Score: 121.62  E-value: 4.03e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2019537954  83 KGPWTKEEDEKVIELVKKYGTKHWTLIAKQLK-GRLGKQCRERWHNHLNPEVKKSSWTEEEDRIICQAHKVLGNRWAEIA 161
Cdd:PLN03091   14 KGLWSPEEDEKLLRHITKYGHGCWSSVPKQAGlQRCGKSCRLRWINYLRPDLKRGTFSQQEENLIIELHAVLGNRWSQIA 93

                          90       100
                  ....*....|....*....|....*..
gi 2019537954 162 KLLPGRTDNAVKNHWNSTIKRKVETGG 188
Cdd:PLN03091   94 AQLPGRTDNEIKNLWNSCLKKKLRQRG 120
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 80-208 8.56e-27

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 115.27  E-value: 8.56e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2019537954  80 DRVKGPWTKEEDEKVIELVKKYGTKHWTLIAKQLKGRLGKQCRERWHNHLNPEVKKSSWTEEEDRIICQAHKVLGNRWAE 159
Cdd:COG5147    17 KRKGGSWKRTEDEDLKALVKKLGPNNWSKVASLLISSTGKQSSNRWNNHLNPQLKKKNWSEEEDEQLIDLDKELGTQWST 96

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2019537954 160 IAKLLPGRTDNAVKNHWNSTIKRKVETGGYLNGMKISITEEKDEKEDSA 208
Cdd:COG5147    97 IADYKDRRTAQQCVERYVNTLEDLSSTHDSKLQRRNEFDKIDPFNENSA 145
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 34-94 3.75e-20

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 84.28  E-value: 3.75e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2019537954  34 WTHEEDEVLRALVKKYGpGEWKQIASHMLNRTEQQCQQRWLRVLHPDRVKGPWTKEEDEKV 94
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYG-NDWKQIAKELGRRTPKQCFDRWRRKLNPKISRGPWSKEEDQRL 60
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 86-144 7.10e-19

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 80.82  E-value: 7.10e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2019537954  86 WTKEEDEKVIELVKKYGTKhWTLIAKQLKGRLGKQCRERWHNHLNPEVKKSSWTEEEDR 144
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYGND-WKQIAKELGRRTPKQCFDRWRRKLNPKISRGPWSKEEDQ 58
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
83-131 3.59e-16

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 72.64  E-value: 3.59e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 2019537954   83 KGPWTKEEDEKVIELVKKYGTKHWTLIAKQLKGRLGKQCRERWHNHLNP 131
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELPGRTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 85-129 8.98e-16

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 71.45  E-value: 8.98e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2019537954  85 PWTKEEDEKVIELVKKYGTKHWTLIAKQLKGRLGKQCRERWHNHL 129
Cdd:cd00167     1 PWTEEEDELLLEAVKKYGKNNWEKIAKELPGRTPKQCRERWRNLL 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
33-79 1.07e-14

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 68.40  E-value: 1.07e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 2019537954   33 KWTHEEDEVLRALVKKYGPGEWKQIASHMLNRTEQQCQQRWLRVLHP 79
Cdd:smart00717   3 EWTEEEDELLIELVKKYGKNNWEKIAKELPGRTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 33-77 2.36e-14

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 67.60  E-value: 2.36e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2019537954  33 KWTHEEDEVLRALVKKYGPGEWKQIASHMLNRTEQQCQQRWLRVL 77
Cdd:cd00167     1 PWTEEEDELLLEAVKKYGKNNWEKIAKELPGRTPKQCRERWRNLL 45
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 15-122 2.64e-03

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 40.93  E-value: 2.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2019537954  15 YQDTDSDvpEHRENRVM------VKWTHEEDEVLRALVKKYGPgEWKQIaSHMLNRTEQQCQQRWLRVLHP--DRVKGPW 86
Cdd:COG5147   271 YRDKKSI--YKHLRRKYnifeqrGKWTKEEEQELAKLVVEHGG-SWTEI-GKLLGRMPNDCRDRWRDYVKCgdTLKRNRW 346

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2019537954  87 TKEEDEKVIELV-KKYGTKH------WTLIAKQLKGRLGKQCR 122
Cdd:COG5147   347 SIEEEELLDKVVnEMRLEAQqssrilWLLIAQNIRNRLQHHCR 389
 
Name Accession Description Interval E-value
Cmyb_C pfam09316
C-myb, C-terminal; Members of this family are predominantly found in the proto-oncogene c-myb ...
 410-553 1.39e-54

C-myb, C-terminal; Members of this family are predominantly found in the proto-oncogene c-myb and the viral transforming protein myb. Truncation of the domain results in 'activation' of c-myb and subsequent tumourigenesis.


Pssm-ID: 462753  Cd Length: 157  Bit Score: 184.49  E-value: 1.39e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2019537954 410 FSPSQFLNFWSKHDALELENPSLTSTPVCSQKVVVTTPLHRDKTPLLQK-NSAFVTPN-HKFMGDNAPHTPTPFKNALE- 486
Cdd:pfam09316   1 FSPSQFLNESSGQENLPLENPTLTSTPVCGQKVFLTTPLHKDQTPKYQKeNTGFRTPNiRRSILETTPRTPTPFKNALAa 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2019537954 487 ---KFGSLRPLPPTP-HLEEDLKEVLRNESGIELVIVDESKHERPKRKPGHsHSPIKKVRKSLALDVVDKE 553
Cdd:pfam09316  81 qekKYGPLKPLPQTPaHLEEDLQEVLKSEIGSDIEIGEDEKPWKQKIKQEH-RSPNKKVRKSLWLDDWDKE 150
PLN03091 PLN03091
hypothetical protein; Provisional
 83-188 4.03e-29

hypothetical protein; Provisional


Pssm-ID: 215570 [Multi-domain]  Cd Length: 459  Bit Score: 121.62  E-value: 4.03e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2019537954  83 KGPWTKEEDEKVIELVKKYGTKHWTLIAKQLK-GRLGKQCRERWHNHLNPEVKKSSWTEEEDRIICQAHKVLGNRWAEIA 161
Cdd:PLN03091   14 KGLWSPEEDEKLLRHITKYGHGCWSSVPKQAGlQRCGKSCRLRWINYLRPDLKRGTFSQQEENLIIELHAVLGNRWSQIA 93

                          90       100
                  ....*....|....*....|....*..
gi 2019537954 162 KLLPGRTDNAVKNHWNSTIKRKVETGG 188
Cdd:PLN03091   94 AQLPGRTDNEIKNLWNSCLKKKLRQRG 120
PLN03212 PLN03212
Transcription repressor MYB5; Provisional
 83-184 6.25e-27

Transcription repressor MYB5; Provisional


Pssm-ID: 178751 [Multi-domain]  Cd Length: 249  Bit Score: 110.17  E-value: 6.25e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2019537954  83 KGPWTKEEDEKVIELVKKYGTKHWTLIAKQLKG-RLGKQCRERWHNHLNPEVKKSSWTEEEDRIICQAHKVLGNRWAEIA 161
Cdd:PLN03212   25 RGPWTVEEDEILVSFIKKEGEGRWRSLPKRAGLlRCGKSCRLRWMNYLRPSVKRGGITSDEEDLILRLHRLLGNRWSLIA 104

                          90       100
                  ....*....|....*....|...
gi 2019537954 162 KLLPGRTDNAVKNHWNSTIKRKV 184
Cdd:PLN03212  105 GRIPGRTDNEIKNYWNTHLRKKL 127
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 80-208 8.56e-27

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 115.27  E-value: 8.56e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2019537954  80 DRVKGPWTKEEDEKVIELVKKYGTKHWTLIAKQLKGRLGKQCRERWHNHLNPEVKKSSWTEEEDRIICQAHKVLGNRWAE 159
Cdd:COG5147    17 KRKGGSWKRTEDEDLKALVKKLGPNNWSKVASLLISSTGKQSSNRWNNHLNPQLKKKNWSEEEDEQLIDLDKELGTQWST 96

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2019537954 160 IAKLLPGRTDNAVKNHWNSTIKRKVETGGYLNGMKISITEEKDEKEDSA 208
Cdd:COG5147    97 IADYKDRRTAQQCVERYVNTLEDLSSTHDSKLQRRNEFDKIDPFNENSA 145
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 34-94 3.75e-20

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 84.28  E-value: 3.75e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2019537954  34 WTHEEDEVLRALVKKYGpGEWKQIASHMLNRTEQQCQQRWLRVLHPDRVKGPWTKEEDEKV 94
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYG-NDWKQIAKELGRRTPKQCFDRWRRKLNPKISRGPWSKEEDQRL 60
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 86-144 7.10e-19

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 80.82  E-value: 7.10e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2019537954  86 WTKEEDEKVIELVKKYGTKhWTLIAKQLKGRLGKQCRERWHNHLNPEVKKSSWTEEEDR 144
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYGND-WKQIAKELGRRTPKQCFDRWRRKLNPKISRGPWSKEEDQ 58
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
83-131 3.59e-16

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 72.64  E-value: 3.59e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 2019537954   83 KGPWTKEEDEKVIELVKKYGTKHWTLIAKQLKGRLGKQCRERWHNHLNP 131
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELPGRTAEQCRERWRNLLKP 49
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 83-129 4.92e-16

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 72.15  E-value: 4.92e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 2019537954  83 KGPWTKEEDEKVIELVKKYGTKhWTLIAKQLKGRLGKQCRERWHNHL 129
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLGNR-WKKIAKLLPGRTDNQCKNRWQNYL 46
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 85-129 8.98e-16

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 71.45  E-value: 8.98e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2019537954  85 PWTKEEDEKVIELVKKYGTKHWTLIAKQLKGRLGKQCRERWHNHL 129
Cdd:cd00167     1 PWTEEEDELLLEAVKKYGKNNWEKIAKELPGRTPKQCRERWRNLL 45
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 135-178 1.15e-15

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 71.38  E-value: 1.15e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2019537954 135 KSSWTEEEDRIICQAHKVLGNRWAEIAKLLPGRTDNAVKNHWNS 178
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQN 44
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
33-79 1.07e-14

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 68.40  E-value: 1.07e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 2019537954   33 KWTHEEDEVLRALVKKYGPGEWKQIASHMLNRTEQQCQQRWLRVLHP 79
Cdd:smart00717   3 EWTEEEDELLIELVKKYGKNNWEKIAKELPGRTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 33-77 2.36e-14

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 67.60  E-value: 2.36e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2019537954  33 KWTHEEDEVLRALVKKYGPGEWKQIASHMLNRTEQQCQQRWLRVL 77
Cdd:cd00167     1 PWTEEEDELLLEAVKKYGKNNWEKIAKELPGRTPKQCRERWRNLL 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
135-182 2.01e-12

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 62.24  E-value: 2.01e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 2019537954  135 KSSWTEEEDRIICQAHKVLG-NRWAEIAKLLPGRTDNAVKNHWNSTIKR 182
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 137-177 2.34e-12

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 61.82  E-value: 2.34e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2019537954 137 SWTEEEDRIICQAHKVLG-NRWAEIAKLLPGRTDNAVKNHWN 177
Cdd:cd00167     1 PWTEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWR 42
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 32-77 2.76e-11

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 58.67  E-value: 2.76e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2019537954  32 VKWTHEEDEVLRALVKKYGpGEWKQIASHMLNRTEQQCQQRWLRVL 77
Cdd:pfam00249   2 GPWTPEEDELLLEAVEKLG-NRWKKIAKLLPGRTDNQCKNRWQNYL 46
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 138-189 3.23e-09

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 53.47  E-value: 3.23e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2019537954 138 WTEEEDRIICQAHKVLGNRWAEIAKLLPGRTDNAVKNHWNSTIKRKVETGGY 189
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYGNDWKQIAKELGRRTPKQCFDRWRRKLNPKISRGPW 52
SANT_TRF cd11660
Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human ...
 32-77 4.56e-08

Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human telomere repeat binding factors, TRF1 and TRF2, function as part of the 6 component shelterin complex. TRF2 binds DNA and recruits RAP1 (via binding to the RAP1 protein c-terminal (RCT)) and TIN2 in the protection of telomeres from DNA repair machinery. Metazoan shelterin consists of 3 DNA binding proteins (TRF2, TRF1, and POT1) and 3 recruited proteins that bind to one or more of these DNA-binding proteins (RAP1, TIN2, TPP1). Schizosaccharomyces pombe TAZ1 is an orthlog and binds RAP1. Human TRF1 and TRF2 bind double-stranded DNA. hTRF2 consists of a basic N-terminus, a TRF homology domain, the RAP1 binding motif (RBM), the TIN2 binding motif (TBM) and a myb-like DNA binding domain, SANT, named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. Tandem copies of the domain bind telomeric DNA tandem repeats as part of the capping complex. The single myb-like domain of TRF-type proteins is similar to the tandem myb_like domains found in yeast RAP1.


Pssm-ID: 212558 [Multi-domain]  Cd Length: 50  Bit Score: 49.87  E-value: 4.56e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2019537954  32 VKWTHEEDEVLRALVKKYGPGEWKQIASH---MLNRTEQQCQQRWlRVL 77
Cdd:cd11660     1 RKWTDEEDEALVEGVEKYGVGNWAKILKDyffVNNRTSVDLKDKW-RNL 48
SANT_CDC5_II cd11659
SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, ...
 83-125 1.99e-07

SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, cell division cycle 5-like protein (CDC5) functions in pre-mRNA splicing in cell cycle control. The DNA-binding, myb-like domain of CDC5 is a member of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of DNA-binding Myb domains and is found in a diverse set of proteins.


Pssm-ID: 212557 [Multi-domain]  Cd Length: 53  Bit Score: 48.07  E-value: 1.99e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2019537954  83 KGPWTKEEDEKVIELVKKYGTKhWTLIAKqLKGRLGKQCRERW 125
Cdd:cd11659     5 KTEWTREEDEKLLHLAKLLPTQ-WRTIAP-IVGRTAQQCLERY 45
SANT_TRF cd11660
Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human ...
 85-127 2.61e-07

Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human telomere repeat binding factors, TRF1 and TRF2, function as part of the 6 component shelterin complex. TRF2 binds DNA and recruits RAP1 (via binding to the RAP1 protein c-terminal (RCT)) and TIN2 in the protection of telomeres from DNA repair machinery. Metazoan shelterin consists of 3 DNA binding proteins (TRF2, TRF1, and POT1) and 3 recruited proteins that bind to one or more of these DNA-binding proteins (RAP1, TIN2, TPP1). Schizosaccharomyces pombe TAZ1 is an orthlog and binds RAP1. Human TRF1 and TRF2 bind double-stranded DNA. hTRF2 consists of a basic N-terminus, a TRF homology domain, the RAP1 binding motif (RBM), the TIN2 binding motif (TBM) and a myb-like DNA binding domain, SANT, named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. Tandem copies of the domain bind telomeric DNA tandem repeats as part of the capping complex. The single myb-like domain of TRF-type proteins is similar to the tandem myb_like domains found in yeast RAP1.


Pssm-ID: 212558 [Multi-domain]  Cd Length: 50  Bit Score: 47.56  E-value: 2.61e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2019537954  85 PWTKEEDEKVIELVKKYGTKHWTLIAKQ---LKGRLGKQCRERWHN 127
Cdd:cd11660     2 KWTDEEDEALVEGVEKYGVGNWAKILKDyffVNNRTSVDLKDKWRN 47
SANT_CDC5_II cd11659
SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, ...
 34-77 1.65e-05

SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, cell division cycle 5-like protein (CDC5) functions in pre-mRNA splicing in cell cycle control. The DNA-binding, myb-like domain of CDC5 is a member of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of DNA-binding Myb domains and is found in a diverse set of proteins.


Pssm-ID: 212557 [Multi-domain]  Cd Length: 53  Bit Score: 42.68  E-value: 1.65e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2019537954  34 WTHEEDEVLRALVKKYgPGEWKQIAShMLNRTEQQCQQRWLRVL 77
Cdd:cd11659     8 WTREEDEKLLHLAKLL-PTQWRTIAP-IVGRTAQQCLERYNKLL 49
SANT_CDC5_II cd11659
SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, ...
 131-170 1.38e-04

SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, cell division cycle 5-like protein (CDC5) functions in pre-mRNA splicing in cell cycle control. The DNA-binding, myb-like domain of CDC5 is a member of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of DNA-binding Myb domains and is found in a diverse set of proteins.


Pssm-ID: 212557 [Multi-domain]  Cd Length: 53  Bit Score: 39.99  E-value: 1.38e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2019537954 131 PEVKKSSWTEEEDRIICQAHKVLGNRWAEIAKLLpGRTDN 170
Cdd:cd11659     1 PSIKKTEWTREEDEKLLHLAKLLPTQWRTIAPIV-GRTAQ 39
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 75-181 3.94e-04

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 43.62  E-value: 3.94e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2019537954  75 RVLHPDRVKGPWTKEEDEKVIELVKKYGtKHWTLIAKqLKGRLGKQCRERWHNHLNP--EVKKSSWT-EEEDRIIC---- 147
Cdd:COG5147   283 RKYNIFEQRGKWTKEEEQELAKLVVEHG-GSWTEIGK-LLGRMPNDCRDRWRDYVKCgdTLKRNRWSiEEEELLDKvvne 360

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2019537954 148 ---QAHKVLGNRWAEIAKLLPGRTDNAVKNHWNSTIK 181
Cdd:COG5147   361 mrlEAQQSSRILWLLIAQNIRNRLQHHCRDKYGVLIS 397
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 15-122 2.64e-03

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 40.93  E-value: 2.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2019537954  15 YQDTDSDvpEHRENRVM------VKWTHEEDEVLRALVKKYGPgEWKQIaSHMLNRTEQQCQQRWLRVLHP--DRVKGPW 86
Cdd:COG5147   271 YRDKKSI--YKHLRRKYnifeqrGKWTKEEEQELAKLVVEHGG-SWTEI-GKLLGRMPNDCRDRWRDYVKCgdTLKRNRW 346

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2019537954  87 TKEEDEKVIELV-KKYGTKH------WTLIAKQLKGRLGKQCR 122
Cdd:COG5147   347 SIEEEELLDKVVnEMRLEAQqssrilWLLIAQNIRNRLQHHCR 389
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH