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Conserved domains on  [gi|2024431659|ref|XP_040511633|]
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adenomatous polyposis coli protein isoform X1 [Gallus gallus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Arm_APC_u3 pfam16629
Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately ...
 785-1075 1.79e-179

Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately downstream of the armadillo fold before the beta-catenin binding motifs, APC_crr, pfam05923, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


:

Pssm-ID: 435476  Cd Length: 293  Bit Score: 551.88  E-value: 1.79e-179
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431659  785 NRPAKYKDTNIMSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLSPKASHRNKQRHKQNIYGEYVLDSSRHDDGVC 864
Cdd:pfam16629    1 NRPAKYKDANIMSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLSPKASHRNKQRHKQNVYSEYVLDSGRHDDSVC 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431659  865 RTESFNTGNMTVLSPYLNSTVLPGSAS-SSRGNIENCLSEKDRSLDRDRAVGLNAYHPATENSGNSSKRIGMQISTAAAQ 943
Cdd:pfam16629   81 RSDNFNTGNVTVLSPYLNTTVLPSSSSrDSRGNAESSRSEKDRSLDRERGAGLSNFHPATENSGNSSKRIGMQISTTAAQ 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431659  944 IAKVMEEVTSMHIPQEDRSSGSTSEMHCLTEDRNTTRRAATAHTHSNTY-FPKSENSSRPCPVPYTKMEYKRASNDSLNS 1022
Cdd:pfam16629  161 IAKVMEEVSSMHISQEDRSSGSTSDMHCMQDDRNSIRRSSTAHPHSNVYsFNKSESSNRPCPMPYMKMEYKRASNDSLNS 240

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2024431659 1023 VSSSDGYGKRGQMKPSIESYSEDDESKFCSYGQYPADLAHKIHSANHMDDNDG 1075
Cdd:pfam16629  241 VSSSDGYGKRGQMKPSVESYSEDDEGKFCSYGKYPADLAHKIHSANHMDDNDG 293
EB1_binding pfam05937
EB-1 Binding Domain; This region, found at the C-terminus of the APC proteins, binds the ...
 2721-2894 2.97e-94

EB-1 Binding Domain; This region, found at the C-terminus of the APC proteins, binds the microtubule-associating protein EB-1. At the C-terminus of the alignment is also a pfam00595 binding domain. A short motif in the middle of the region appears to be found in the APC2 proteins.


:

Pssm-ID: 399141  Cd Length: 174  Bit Score: 302.69  E-value: 2.97e-94
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431659 2721 RSGRSPTGNTPPVIDSVSEKGVVNGKDSKEIQEKQNPGNGSVPVRTIGLENRLNSFFQMDSPDKKGNETKPLQTNPVPAP 2800
Cdd:pfam05937    1 RSGRSPTGNTPPVIDSVPEKGIKDEKDSKDPQAKQNMGNGNVPVRTVGLENRLNSFIQSDSPDKKGTETKPLQNNPVPTP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431659 2801 ENNESTVSERTPFSSSSSSKHNSPIGAVAARVTPFNYNPSRRKSSVDNSSARPSQIPTPVNNSTKKRDSKSENTDSSGTQ 2880
Cdd:pfam05937   81 ETNENPVSERTPFSSSSSSKHSSPSGAVAARVTPFNYNPSPRKSSADSSSARPSQIPTPVNNSTKKRDSKTESTDSSGNQ 160

                          170
                   ....*....|....
gi 2024431659 2881 SPKRHSGSYLVTSV 2894
Cdd:pfam05937  161 SPKRHSGSYLVTSV 174
APC_basic pfam05956
APC basic domain; This region of the APC family of proteins is known as the basic domain. It ...
 2273-2618 1.80e-90

APC basic domain; This region of the APC family of proteins is known as the basic domain. It contains a high proportion of positively charged amino acids and interacts with microtubules.


:

Pssm-ID: 428690 [Multi-domain]  Cd Length: 336  Bit Score: 298.71  E-value: 1.80e-90
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431659 2273 SISRGRTMIHIPGVRNSSSSTSPVSKKGPPFKNTNSKSPSEGQ-SSASSPRGVKSSVKPEPAPVTRQLSglNQGGSSKGP 2351
Cdd:pfam05956    1 VVFRGRTVIYMPGVKESQPSTSPPPKKTPPKTDAPAKNPNLGQqRSRSLHRLGKPSELADLSPPKRSAT--PPARISKAP 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431659 2352 SRSGSRDSTPSRPQQQPLSRPLQSPGRNSISPGRNGISPPNKLSQLPRTSSPSTAStkssssgRMSYTSPGRQMSQQNLT 2431
Cdd:pfam05956   79 SSGSSRDSTPSRPPQKKLTSPSQSPGRLPGSGGRNKLSPLPKTKSPARASTKKSGS-------HKTQKSPVRIPFMQTPT 151

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431659 2432 KQTALTKNTSSI------PRSESASKGLNqilgsGASNKKTDLSRMSSAKSSGSESDRSerpVLVRQSTFIKEAPSPTLR 2505
Cdd:pfam05956  152 KQTGLPRNPSPLvtnqpePRSESASKGLR-----SLPGKRLDLVRMSSARSSGSESDRS---GFLRQLTFIKESPSLLLR 223

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431659 2506 RKLEESASfESLSP-SRPDSPTRSQlqtpvlsPSLPDMSLSTHSTAQTSGWRKLPPNLSPSVEY-DGRPAKRHDIARSHS 2583
Cdd:pfam05956  224 RRLELSAS-ESLSPsSQPASPRRSR-------PGLPAVFLCSSRCQELKGWRKQPPNPNSRAEPsDRPLTRRRPPRRTSS 295

                          330       340       350
                   ....*....|....*....|....*....|....*
gi 2024431659 2584 ESPSRLPInRSGTWKREHSKHSSSLPRVSTWRRTG 2618
Cdd:pfam05956  296 ESPSRLPV-RNGTWKRETFKRYSSLPHINVWRRTG 329
APC_u5 pfam16630
Unstructured region on APC between 1st and 2nd catenin-bdg motifs; APC_u5 is a short region of ...
 1092-1191 1.18e-56

Unstructured region on APC between 1st and 2nd catenin-bdg motifs; APC_u5 is a short region of natively unstructured sequence lying between the first and the second 15-residue beta-catenin binding motifs, APC_15aa, pfam05972, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


:

Pssm-ID: 406923  Cd Length: 100  Bit Score: 191.66  E-value: 1.18e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431659 1092 LNSGRQSPSQNERWARPKHIIDDEMKQNDQRQSRSQSATYPVYTESGDDKHMKYQSPFGQQDCVPSFRSRGSNGSDQNRV 1171
Cdd:pfam16630    1 LNSGRQSPSQNERWARPKHIIEDEMKQSEQRQPRSQSTTYPVYTESGDDKHMKFQPRFGQQECVSPFRSRGSNGSEQSRV 80

                           90       100
                   ....*....|....*....|
gi 2024431659 1172 GSTLGINQKVNQSLCQVDDY 1191
Cdd:pfam16630   81 GSSHGINQKVSQSLCQVDDY 100
APC_u14 pfam16635
Unstructured region on APC between SAMP and APC_crr; APC_u14 is a short region of natively ...
 1804-1895 6.19e-48

Unstructured region on APC between SAMP and APC_crr; APC_u14 is a short region of natively unstructured sequence lying between the second SAMP pfam05924, and the fifth creatine-rich region, APC_crr, pfam05923, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


:

Pssm-ID: 435479  Cd Length: 94  Bit Score: 166.55  E-value: 6.19e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431659 1804 IMDQIQQAST--SLNNKNQPEGEKKKPTSPVKPVPQNSEYRARVRKNTESKSQINNERSYPENRDAKKQNLKNNSRDFND 1881
Cdd:pfam16635    1 IMDQIQQASAasSGGSKSQQDGEKKKPTSPVKPMPQSSEYRARVRKNTESKNNLNSERSYPDNKESKKQNLKNNSRDFND 80

                           90
                   ....*....|....
gi 2024431659 1882 KLPNNEERVRGSFT 1895
Cdd:pfam16635   81 KLPNNEERTRGSFA 94
APC_rep pfam18797
Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo ...
 446-519 5.17e-44

Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo repeat and uses its highly conserved surface groove to recognize the APC-binding region (ABR) of Asef. This entry represents a single repeat unit of the Armadillo region.


:

Pssm-ID: 465870  Cd Length: 74  Bit Score: 154.63  E-value: 5.17e-44
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2024431659  446 SQPDDKRGRREIRVLHLLEQIRAYCETCWEWQEAHEQGMDQDKNPMPAPVDHQICPAVCVLMKLSFDEEHRHAM 519
Cdd:pfam18797    1 SQPDDKRGRREMRVLHLLEQIRAYCETCWDWQESHSRGPEGDSNPMPSPIEHQICPAICALMKLSFDEEHRHAM 74
APC_u9 pfam16633
Unstructured region on APC between 1st two creatine-rich regions; APC_u9 is a short region of ...
 1340-1426 4.75e-35

Unstructured region on APC between 1st two creatine-rich regions; APC_u9 is a short region of natively unstructured sequence lying between the first and second APC_crr, pfam05923, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


:

Pssm-ID: 435478  Cd Length: 89  Bit Score: 129.61  E-value: 4.75e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431659 1340 AEDEI-GRDQSTRVTDTNATLQISELKENSGALSAEAAVSEITSTSQHIRTKSSRLPTSSLSPSESSRHKAVEFSSGAKS 1418
Cdd:pfam16633    2 AEDEIeGRDQATRSTDNYNTLQITELKENSGAVSTEQTVSEVPSSSQHIRTKPNRLQASNLSPSDSSRHKAVEFSSGAKS 81


                   ....*...
gi 2024431659 1419 PSKSGAQT 1426
Cdd:pfam16633   82 PSKSGAQT 89
APC_u15 pfam16636
Unstructured region on APC between APC_crr regions 5 and 6; APC_u15 is a short region of ...
 1929-1996 3.76e-27

Unstructured region on APC between APC_crr regions 5 and 6; APC_u15 is a short region of natively unstructured sequence lying between the fifth and sixth creatine-rich, APC_crr, pfam05923, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


:

Pssm-ID: 435480  Cd Length: 81  Bit Score: 106.87  E-value: 3.76e-27
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2024431659 1929 DLSREKAELRKGKEAKEVETKDCPNVEQPSGQQPSNRTQVCQKHPTSRSQSK-------TFCQPSKDIPDRGAAT 1996
Cdd:pfam16636    7 DLSREKAELRKGKETKETETKVTSHIEQPSNQQSTNRTQACQKHPPNRGQPKpllqkqtTFPQSSKDIPDRGAAT 81
APC_u13 pfam16634
Unstructured region on APC between APC_crr and SAMP; APC_u13 is a short region of natively ...
 1720-1773 1.05e-26

Unstructured region on APC between APC_crr and SAMP; APC_u13 is a short region of natively unstructured sequence lying between the fourth creatine-rich region, APC_crr, pfam05923, and the SAMP pfam05924, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


:

Pssm-ID: 406927  Cd Length: 54  Bit Score: 104.49  E-value: 1.05e-26
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2024431659 1720 IESPPNELANVDSVGAGAESGEFEKRDTIPTEGRSTDDTQRAKSITVTGPGLDD 1773
Cdd:pfam16634    1 IESPPNELANAESTGTGAESAEFEKRDTIPTEGRSTDDAQRGKKSNITTSALDD 54
APC_N_CC pfam16689
Coiled-coil N-terminus of APC, dimerization domain; APC_N_CC is the N-terminal, coiled-coil ...
 4-67 3.40e-19

Coiled-coil N-terminus of APC, dimerization domain; APC_N_CC is the N-terminal, coiled-coil dimerization domain of the adenomatosis polyposis coli (APC) tumour-repressor proteins. It plays a key role in the regulation of cellular levels of the oncogene product beta-catenin. Coiled-coil regions are binding repeats that in this case bind to the armadillo repeat region of beta-catenin.


:

Pssm-ID: 435517  Cd Length: 52  Bit Score: 83.11  E-value: 3.40e-19
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2024431659    4 ASYDQLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNMKmvdpagictyleEVLKQLQGSI 67
Cdd:pfam16689    1 ASYDQLLRQVEALKLENTTLRQELRDNSSHLSKLETEASNMK------------EVLKHLQGSI 52
Suppressor_APC pfam11414
Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has ...
 139-219 9.96e-13

Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has a nuclear export activity as well as many different intracellular functions. The structure consists of three alpha-helices forming two separate antiparallel coiled coils.


:

Pssm-ID: 463275  Cd Length: 82  Bit Score: 65.74  E-value: 9.96e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431659  139 SRESTGYLEELEKERSLLLAELEKEEKEKDWYYAQLQNLTKRIDSLPLTE-NFSLQTDMTRRQLEYEARQIRAAMEEQLG 217
Cdd:pfam11414    1 DYNMLKRMKQLEQEKDVLLQGLEMVERARDWYQQQLQEVQERQKYLGANGtYFDYGSDAQQERLEFLLARIQEVNRCLGG 80


                   ..
gi 2024431659  218 TC 219
Cdd:pfam11414   81 LI 82
APC_r pfam05923
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1695-1718 1.93e-07

APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.


:

Pssm-ID: 461781  Cd Length: 24  Bit Score: 48.92  E-value: 1.93e-07
                           10        20
                   ....*....|....*....|....
gi 2024431659 1695 DMPRVYCVEGTPINFSTATSLSDL 1718
Cdd:pfam05923    1 DSPKRYCVEGTPANFSRASSLSSL 24
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 702-742 2.48e-06

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


:

Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 46.27  E-value: 2.48e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2024431659   702 NEDHRQILRENSCLQTLLQHLKSHSLTIVSNACGTLWNLSA 742
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
SAMP pfam05924
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis ...
 2083-2102 4.21e-05

SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). This motif binds axin.


:

Pssm-ID: 461782  Cd Length: 22  Bit Score: 42.58  E-value: 4.21e-05
                           10        20
                   ....*....|....*....|
gi 2024431659 2083 DSEDDLLQECISSAMPKKKK 2102
Cdd:pfam05924    3 DDEDDLLQECINSAMPKKRR 22
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 565-606 5.35e-04

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


:

Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 39.72  E-value: 5.35e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2024431659   565 DVANKATLCSMkGCMRALVAQLKSESEDLQQVIASVLRNLSW 606
Cdd:smart00185    1 DDENKQAVVDA-GGLPALVELLKSEDEEVVKEAAWALSNLSS 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 393-445 1.59e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


:

Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 38.56  E-value: 1.59e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 2024431659   393 SQDSCIAMRQSGCLPLLIQLLHgndkdsvllgnsRGSKEARARASAALHNIIH 445
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLK------------SEDEEVVKEAAWALSNLSS 41
SAMP pfam05924
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1774-1795 2.46e-03

SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). This motif binds axin.


:

Pssm-ID: 461782  Cd Length: 22  Bit Score: 37.57  E-value: 2.46e-03
                           10        20
                   ....*....|....*....|..
gi 2024431659 1774 DKTEEGDILAECINSAMPKGKS 1795
Cdd:pfam05924    1 SPDDEDDLLQECINSAMPKKRR 22
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 744-784 2.51e-03

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


:

Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 37.82  E-value: 2.51e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2024431659  744 NAKDQEALWDMGAVSMLKNLIHSKHKMIAMGSAAALRNLMA 784
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
APC_r pfam05923
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1429-1451 4.42e-03

APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.


:

Pssm-ID: 461781  Cd Length: 24  Bit Score: 36.59  E-value: 4.42e-03
                           10        20
                   ....*....|....*....|....
gi 2024431659 1429 SPPEHY-VQETPLMFSRCTSVSSL 1451
Cdd:pfam05923    1 DSPKRYcVEGTPANFSRASSLSSL 24
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 512-563 5.04e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


:

Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 37.02  E-value: 5.04e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 2024431659   512 DEEHRHAMNELGGLQAIAELLQvdcemygltndHYSVTLRRYAGMALTNLTF 563
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLK-----------SEDEEVVKEAAWALSNLSS 41
APC_r pfam05923
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1314-1331 8.29e-03

APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.


:

Pssm-ID: 461781  Cd Length: 24  Bit Score: 35.82  E-value: 8.29e-03
                           10
                   ....*....|....*...
gi 2024431659 1314 ETIQTYCVEDTPICFSRC 1331
Cdd:pfam05923    1 DSPKRYCVEGTPANFSRA 18
 
Name Accession Description Interval E-value
Arm_APC_u3 pfam16629
Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately ...
 785-1075 1.79e-179

Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately downstream of the armadillo fold before the beta-catenin binding motifs, APC_crr, pfam05923, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 435476  Cd Length: 293  Bit Score: 551.88  E-value: 1.79e-179
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431659  785 NRPAKYKDTNIMSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLSPKASHRNKQRHKQNIYGEYVLDSSRHDDGVC 864
Cdd:pfam16629    1 NRPAKYKDANIMSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLSPKASHRNKQRHKQNVYSEYVLDSGRHDDSVC 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431659  865 RTESFNTGNMTVLSPYLNSTVLPGSAS-SSRGNIENCLSEKDRSLDRDRAVGLNAYHPATENSGNSSKRIGMQISTAAAQ 943
Cdd:pfam16629   81 RSDNFNTGNVTVLSPYLNTTVLPSSSSrDSRGNAESSRSEKDRSLDRERGAGLSNFHPATENSGNSSKRIGMQISTTAAQ 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431659  944 IAKVMEEVTSMHIPQEDRSSGSTSEMHCLTEDRNTTRRAATAHTHSNTY-FPKSENSSRPCPVPYTKMEYKRASNDSLNS 1022
Cdd:pfam16629  161 IAKVMEEVSSMHISQEDRSSGSTSDMHCMQDDRNSIRRSSTAHPHSNVYsFNKSESSNRPCPMPYMKMEYKRASNDSLNS 240

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2024431659 1023 VSSSDGYGKRGQMKPSIESYSEDDESKFCSYGQYPADLAHKIHSANHMDDNDG 1075
Cdd:pfam16629  241 VSSSDGYGKRGQMKPSVESYSEDDEGKFCSYGKYPADLAHKIHSANHMDDNDG 293
EB1_binding pfam05937
EB-1 Binding Domain; This region, found at the C-terminus of the APC proteins, binds the ...
 2721-2894 2.97e-94

EB-1 Binding Domain; This region, found at the C-terminus of the APC proteins, binds the microtubule-associating protein EB-1. At the C-terminus of the alignment is also a pfam00595 binding domain. A short motif in the middle of the region appears to be found in the APC2 proteins.


Pssm-ID: 399141  Cd Length: 174  Bit Score: 302.69  E-value: 2.97e-94
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431659 2721 RSGRSPTGNTPPVIDSVSEKGVVNGKDSKEIQEKQNPGNGSVPVRTIGLENRLNSFFQMDSPDKKGNETKPLQTNPVPAP 2800
Cdd:pfam05937    1 RSGRSPTGNTPPVIDSVPEKGIKDEKDSKDPQAKQNMGNGNVPVRTVGLENRLNSFIQSDSPDKKGTETKPLQNNPVPTP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431659 2801 ENNESTVSERTPFSSSSSSKHNSPIGAVAARVTPFNYNPSRRKSSVDNSSARPSQIPTPVNNSTKKRDSKSENTDSSGTQ 2880
Cdd:pfam05937   81 ETNENPVSERTPFSSSSSSKHSSPSGAVAARVTPFNYNPSPRKSSADSSSARPSQIPTPVNNSTKKRDSKTESTDSSGNQ 160

                          170
                   ....*....|....
gi 2024431659 2881 SPKRHSGSYLVTSV 2894
Cdd:pfam05937  161 SPKRHSGSYLVTSV 174
APC_basic pfam05956
APC basic domain; This region of the APC family of proteins is known as the basic domain. It ...
 2273-2618 1.80e-90

APC basic domain; This region of the APC family of proteins is known as the basic domain. It contains a high proportion of positively charged amino acids and interacts with microtubules.


Pssm-ID: 428690 [Multi-domain]  Cd Length: 336  Bit Score: 298.71  E-value: 1.80e-90
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431659 2273 SISRGRTMIHIPGVRNSSSSTSPVSKKGPPFKNTNSKSPSEGQ-SSASSPRGVKSSVKPEPAPVTRQLSglNQGGSSKGP 2351
Cdd:pfam05956    1 VVFRGRTVIYMPGVKESQPSTSPPPKKTPPKTDAPAKNPNLGQqRSRSLHRLGKPSELADLSPPKRSAT--PPARISKAP 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431659 2352 SRSGSRDSTPSRPQQQPLSRPLQSPGRNSISPGRNGISPPNKLSQLPRTSSPSTAStkssssgRMSYTSPGRQMSQQNLT 2431
Cdd:pfam05956   79 SSGSSRDSTPSRPPQKKLTSPSQSPGRLPGSGGRNKLSPLPKTKSPARASTKKSGS-------HKTQKSPVRIPFMQTPT 151

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431659 2432 KQTALTKNTSSI------PRSESASKGLNqilgsGASNKKTDLSRMSSAKSSGSESDRSerpVLVRQSTFIKEAPSPTLR 2505
Cdd:pfam05956  152 KQTGLPRNPSPLvtnqpePRSESASKGLR-----SLPGKRLDLVRMSSARSSGSESDRS---GFLRQLTFIKESPSLLLR 223

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431659 2506 RKLEESASfESLSP-SRPDSPTRSQlqtpvlsPSLPDMSLSTHSTAQTSGWRKLPPNLSPSVEY-DGRPAKRHDIARSHS 2583
Cdd:pfam05956  224 RRLELSAS-ESLSPsSQPASPRRSR-------PGLPAVFLCSSRCQELKGWRKQPPNPNSRAEPsDRPLTRRRPPRRTSS 295

                          330       340       350
                   ....*....|....*....|....*....|....*
gi 2024431659 2584 ESPSRLPInRSGTWKREHSKHSSSLPRVSTWRRTG 2618
Cdd:pfam05956  296 ESPSRLPV-RNGTWKRETFKRYSSLPHINVWRRTG 329
APC_u5 pfam16630
Unstructured region on APC between 1st and 2nd catenin-bdg motifs; APC_u5 is a short region of ...
 1092-1191 1.18e-56

Unstructured region on APC between 1st and 2nd catenin-bdg motifs; APC_u5 is a short region of natively unstructured sequence lying between the first and the second 15-residue beta-catenin binding motifs, APC_15aa, pfam05972, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 406923  Cd Length: 100  Bit Score: 191.66  E-value: 1.18e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431659 1092 LNSGRQSPSQNERWARPKHIIDDEMKQNDQRQSRSQSATYPVYTESGDDKHMKYQSPFGQQDCVPSFRSRGSNGSDQNRV 1171
Cdd:pfam16630    1 LNSGRQSPSQNERWARPKHIIEDEMKQSEQRQPRSQSTTYPVYTESGDDKHMKFQPRFGQQECVSPFRSRGSNGSEQSRV 80

                           90       100
                   ....*....|....*....|
gi 2024431659 1172 GSTLGINQKVNQSLCQVDDY 1191
Cdd:pfam16630   81 GSSHGINQKVSQSLCQVDDY 100
APC_u14 pfam16635
Unstructured region on APC between SAMP and APC_crr; APC_u14 is a short region of natively ...
 1804-1895 6.19e-48

Unstructured region on APC between SAMP and APC_crr; APC_u14 is a short region of natively unstructured sequence lying between the second SAMP pfam05924, and the fifth creatine-rich region, APC_crr, pfam05923, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 435479  Cd Length: 94  Bit Score: 166.55  E-value: 6.19e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431659 1804 IMDQIQQAST--SLNNKNQPEGEKKKPTSPVKPVPQNSEYRARVRKNTESKSQINNERSYPENRDAKKQNLKNNSRDFND 1881
Cdd:pfam16635    1 IMDQIQQASAasSGGSKSQQDGEKKKPTSPVKPMPQSSEYRARVRKNTESKNNLNSERSYPDNKESKKQNLKNNSRDFND 80

                           90
                   ....*....|....
gi 2024431659 1882 KLPNNEERVRGSFT 1895
Cdd:pfam16635   81 KLPNNEERTRGSFA 94
APC_rep pfam18797
Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo ...
 446-519 5.17e-44

Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo repeat and uses its highly conserved surface groove to recognize the APC-binding region (ABR) of Asef. This entry represents a single repeat unit of the Armadillo region.


Pssm-ID: 465870  Cd Length: 74  Bit Score: 154.63  E-value: 5.17e-44
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2024431659  446 SQPDDKRGRREIRVLHLLEQIRAYCETCWEWQEAHEQGMDQDKNPMPAPVDHQICPAVCVLMKLSFDEEHRHAM 519
Cdd:pfam18797    1 SQPDDKRGRREMRVLHLLEQIRAYCETCWDWQESHSRGPEGDSNPMPSPIEHQICPAICALMKLSFDEEHRHAM 74
APC_u9 pfam16633
Unstructured region on APC between 1st two creatine-rich regions; APC_u9 is a short region of ...
 1340-1426 4.75e-35

Unstructured region on APC between 1st two creatine-rich regions; APC_u9 is a short region of natively unstructured sequence lying between the first and second APC_crr, pfam05923, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 435478  Cd Length: 89  Bit Score: 129.61  E-value: 4.75e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431659 1340 AEDEI-GRDQSTRVTDTNATLQISELKENSGALSAEAAVSEITSTSQHIRTKSSRLPTSSLSPSESSRHKAVEFSSGAKS 1418
Cdd:pfam16633    2 AEDEIeGRDQATRSTDNYNTLQITELKENSGAVSTEQTVSEVPSSSQHIRTKPNRLQASNLSPSDSSRHKAVEFSSGAKS 81


                   ....*...
gi 2024431659 1419 PSKSGAQT 1426
Cdd:pfam16633   82 PSKSGAQT 89
APC_u15 pfam16636
Unstructured region on APC between APC_crr regions 5 and 6; APC_u15 is a short region of ...
 1929-1996 3.76e-27

Unstructured region on APC between APC_crr regions 5 and 6; APC_u15 is a short region of natively unstructured sequence lying between the fifth and sixth creatine-rich, APC_crr, pfam05923, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 435480  Cd Length: 81  Bit Score: 106.87  E-value: 3.76e-27
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2024431659 1929 DLSREKAELRKGKEAKEVETKDCPNVEQPSGQQPSNRTQVCQKHPTSRSQSK-------TFCQPSKDIPDRGAAT 1996
Cdd:pfam16636    7 DLSREKAELRKGKETKETETKVTSHIEQPSNQQSTNRTQACQKHPPNRGQPKpllqkqtTFPQSSKDIPDRGAAT 81
APC_u13 pfam16634
Unstructured region on APC between APC_crr and SAMP; APC_u13 is a short region of natively ...
 1720-1773 1.05e-26

Unstructured region on APC between APC_crr and SAMP; APC_u13 is a short region of natively unstructured sequence lying between the fourth creatine-rich region, APC_crr, pfam05923, and the SAMP pfam05924, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 406927  Cd Length: 54  Bit Score: 104.49  E-value: 1.05e-26
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2024431659 1720 IESPPNELANVDSVGAGAESGEFEKRDTIPTEGRSTDDTQRAKSITVTGPGLDD 1773
Cdd:pfam16634    1 IESPPNELANAESTGTGAESAEFEKRDTIPTEGRSTDDAQRGKKSNITTSALDD 54
APC_N_CC pfam16689
Coiled-coil N-terminus of APC, dimerization domain; APC_N_CC is the N-terminal, coiled-coil ...
 4-67 3.40e-19

Coiled-coil N-terminus of APC, dimerization domain; APC_N_CC is the N-terminal, coiled-coil dimerization domain of the adenomatosis polyposis coli (APC) tumour-repressor proteins. It plays a key role in the regulation of cellular levels of the oncogene product beta-catenin. Coiled-coil regions are binding repeats that in this case bind to the armadillo repeat region of beta-catenin.


Pssm-ID: 435517  Cd Length: 52  Bit Score: 83.11  E-value: 3.40e-19
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2024431659    4 ASYDQLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNMKmvdpagictyleEVLKQLQGSI 67
Cdd:pfam16689    1 ASYDQLLRQVEALKLENTTLRQELRDNSSHLSKLETEASNMK------------EVLKHLQGSI 52
Suppressor_APC pfam11414
Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has ...
 139-219 9.96e-13

Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has a nuclear export activity as well as many different intracellular functions. The structure consists of three alpha-helices forming two separate antiparallel coiled coils.


Pssm-ID: 463275  Cd Length: 82  Bit Score: 65.74  E-value: 9.96e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431659  139 SRESTGYLEELEKERSLLLAELEKEEKEKDWYYAQLQNLTKRIDSLPLTE-NFSLQTDMTRRQLEYEARQIRAAMEEQLG 217
Cdd:pfam11414    1 DYNMLKRMKQLEQEKDVLLQGLEMVERARDWYQQQLQEVQERQKYLGANGtYFDYGSDAQQERLEFLLARIQEVNRCLGG 80


                   ..
gi 2024431659  218 TC 219
Cdd:pfam11414   81 LI 82
APC_r pfam05923
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1695-1718 1.93e-07

APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.


Pssm-ID: 461781  Cd Length: 24  Bit Score: 48.92  E-value: 1.93e-07
                           10        20
                   ....*....|....*....|....
gi 2024431659 1695 DMPRVYCVEGTPINFSTATSLSDL 1718
Cdd:pfam05923    1 DSPKRYCVEGTPANFSRASSLSSL 24
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 702-742 2.48e-06

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 46.27  E-value: 2.48e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2024431659   702 NEDHRQILRENSCLQTLLQHLKSHSLTIVSNACGTLWNLSA 742
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 702-742 3.24e-06

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 45.91  E-value: 3.24e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2024431659  702 NEDHRQILRENSCLQTLLQHLKSHSLTIVSNACGTLWNLSA 742
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
SAMP pfam05924
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis ...
 2083-2102 4.21e-05

SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). This motif binds axin.


Pssm-ID: 461782  Cd Length: 22  Bit Score: 42.58  E-value: 4.21e-05
                           10        20
                   ....*....|....*....|
gi 2024431659 2083 DSEDDLLQECISSAMPKKKK 2102
Cdd:pfam05924    3 DDEDDLLQECINSAMPKKRR 22
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 565-606 5.35e-04

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 39.72  E-value: 5.35e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2024431659   565 DVANKATLCSMkGCMRALVAQLKSESEDLQQVIASVLRNLSW 606
Cdd:smart00185    1 DDENKQAVVDA-GGLPALVELLKSEDEEVVKEAAWALSNLSS 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 565-605 6.15e-04

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 39.36  E-value: 6.15e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2024431659  565 DVANKATLCSMkGCMRALVAQLKSESEDLQQVIASVLRNLS 605
Cdd:pfam00514    1 SPENKQAVIEA-GAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 393-445 1.59e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 38.56  E-value: 1.59e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 2024431659   393 SQDSCIAMRQSGCLPLLIQLLHgndkdsvllgnsRGSKEARARASAALHNIIH 445
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLK------------SEDEEVVKEAAWALSNLSS 41
PHA03247 PHA03247
large tegument protein UL36; Provisional
 2301-2614 2.28e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 2.28e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431659 2301 PPFKNTNSKSPSEGQSSASSPRGVKSSVKPEPAPVTRQLSGLNQGGSSK--GPSRSGSRDSTPSRPQQQPLSRPLQSPGR 2378
Cdd:PHA03247  2702 PPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATpgGPARPARPPTTAGPPAPAPPAAPAAGPPR 2781

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431659 2379 NSISPGRNGISPPNKLSQLPRTSSPSTASTKSSSSGRMSYTSPGRQMSQQNLTKQTALTKNTSSIPRSESASkglnqilg 2458
Cdd:PHA03247  2782 RLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLG-------- 2853

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431659 2459 sGASNKKTDLSRMSSAKSSGSESDRSERPVLVR-------QSTFIKEAPSPTLRRKLEESASFESLSPSRPDSPTRSQLQ 2531
Cdd:PHA03247  2854 -GSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRlarpavsRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPP 2932

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431659 2532 TPvlSPSLPDMSLS-THSTAQTSGWRKLPPNLSPSVEYDGR-PAKRhdiARSHSESPSRlPINRSGTwkreHSKHSSSLP 2609
Cdd:PHA03247  2933 PP--PPPRPQPPLApTTDPAGAGEPSGAVPQPWLGALVPGRvAVPR---FRVPQPAPSR-EAPASST----PPLTGHSLS 3002


                   ....*
gi 2024431659 2610 RVSTW 2614
Cdd:PHA03247  3003 RVSSW 3007
SAMP pfam05924
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1774-1795 2.46e-03

SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). This motif binds axin.


Pssm-ID: 461782  Cd Length: 22  Bit Score: 37.57  E-value: 2.46e-03
                           10        20
                   ....*....|....*....|..
gi 2024431659 1774 DKTEEGDILAECINSAMPKGKS 1795
Cdd:pfam05924    1 SPDDEDDLLQECINSAMPKKRR 22
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 744-784 2.51e-03

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 37.82  E-value: 2.51e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2024431659  744 NAKDQEALWDMGAVSMLKNLIHSKHKMIAMGSAAALRNLMA 784
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
APC_r pfam05923
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1429-1451 4.42e-03

APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.


Pssm-ID: 461781  Cd Length: 24  Bit Score: 36.59  E-value: 4.42e-03
                           10        20
                   ....*....|....*....|....
gi 2024431659 1429 SPPEHY-VQETPLMFSRCTSVSSL 1451
Cdd:pfam05923    1 DSPKRYcVEGTPANFSRASSLSSL 24
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 512-563 5.04e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 37.02  E-value: 5.04e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 2024431659   512 DEEHRHAMNELGGLQAIAELLQvdcemygltndHYSVTLRRYAGMALTNLTF 563
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLK-----------SEDEEVVKEAAWALSNLSS 41
APC_r pfam05923
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1314-1331 8.29e-03

APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.


Pssm-ID: 461781  Cd Length: 24  Bit Score: 35.82  E-value: 8.29e-03
                           10
                   ....*....|....*...
gi 2024431659 1314 ETIQTYCVEDTPICFSRC 1331
Cdd:pfam05923    1 DSPKRYCVEGTPANFSRA 18
 
Name Accession Description Interval E-value
Arm_APC_u3 pfam16629
Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately ...
 785-1075 1.79e-179

Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately downstream of the armadillo fold before the beta-catenin binding motifs, APC_crr, pfam05923, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 435476  Cd Length: 293  Bit Score: 551.88  E-value: 1.79e-179
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431659  785 NRPAKYKDTNIMSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLSPKASHRNKQRHKQNIYGEYVLDSSRHDDGVC 864
Cdd:pfam16629    1 NRPAKYKDANIMSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLSPKASHRNKQRHKQNVYSEYVLDSGRHDDSVC 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431659  865 RTESFNTGNMTVLSPYLNSTVLPGSAS-SSRGNIENCLSEKDRSLDRDRAVGLNAYHPATENSGNSSKRIGMQISTAAAQ 943
Cdd:pfam16629   81 RSDNFNTGNVTVLSPYLNTTVLPSSSSrDSRGNAESSRSEKDRSLDRERGAGLSNFHPATENSGNSSKRIGMQISTTAAQ 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431659  944 IAKVMEEVTSMHIPQEDRSSGSTSEMHCLTEDRNTTRRAATAHTHSNTY-FPKSENSSRPCPVPYTKMEYKRASNDSLNS 1022
Cdd:pfam16629  161 IAKVMEEVSSMHISQEDRSSGSTSDMHCMQDDRNSIRRSSTAHPHSNVYsFNKSESSNRPCPMPYMKMEYKRASNDSLNS 240

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2024431659 1023 VSSSDGYGKRGQMKPSIESYSEDDESKFCSYGQYPADLAHKIHSANHMDDNDG 1075
Cdd:pfam16629  241 VSSSDGYGKRGQMKPSVESYSEDDEGKFCSYGKYPADLAHKIHSANHMDDNDG 293
EB1_binding pfam05937
EB-1 Binding Domain; This region, found at the C-terminus of the APC proteins, binds the ...
 2721-2894 2.97e-94

EB-1 Binding Domain; This region, found at the C-terminus of the APC proteins, binds the microtubule-associating protein EB-1. At the C-terminus of the alignment is also a pfam00595 binding domain. A short motif in the middle of the region appears to be found in the APC2 proteins.


Pssm-ID: 399141  Cd Length: 174  Bit Score: 302.69  E-value: 2.97e-94
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431659 2721 RSGRSPTGNTPPVIDSVSEKGVVNGKDSKEIQEKQNPGNGSVPVRTIGLENRLNSFFQMDSPDKKGNETKPLQTNPVPAP 2800
Cdd:pfam05937    1 RSGRSPTGNTPPVIDSVPEKGIKDEKDSKDPQAKQNMGNGNVPVRTVGLENRLNSFIQSDSPDKKGTETKPLQNNPVPTP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431659 2801 ENNESTVSERTPFSSSSSSKHNSPIGAVAARVTPFNYNPSRRKSSVDNSSARPSQIPTPVNNSTKKRDSKSENTDSSGTQ 2880
Cdd:pfam05937   81 ETNENPVSERTPFSSSSSSKHSSPSGAVAARVTPFNYNPSPRKSSADSSSARPSQIPTPVNNSTKKRDSKTESTDSSGNQ 160

                          170
                   ....*....|....
gi 2024431659 2881 SPKRHSGSYLVTSV 2894
Cdd:pfam05937  161 SPKRHSGSYLVTSV 174
APC_basic pfam05956
APC basic domain; This region of the APC family of proteins is known as the basic domain. It ...
 2273-2618 1.80e-90

APC basic domain; This region of the APC family of proteins is known as the basic domain. It contains a high proportion of positively charged amino acids and interacts with microtubules.


Pssm-ID: 428690 [Multi-domain]  Cd Length: 336  Bit Score: 298.71  E-value: 1.80e-90
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431659 2273 SISRGRTMIHIPGVRNSSSSTSPVSKKGPPFKNTNSKSPSEGQ-SSASSPRGVKSSVKPEPAPVTRQLSglNQGGSSKGP 2351
Cdd:pfam05956    1 VVFRGRTVIYMPGVKESQPSTSPPPKKTPPKTDAPAKNPNLGQqRSRSLHRLGKPSELADLSPPKRSAT--PPARISKAP 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431659 2352 SRSGSRDSTPSRPQQQPLSRPLQSPGRNSISPGRNGISPPNKLSQLPRTSSPSTAStkssssgRMSYTSPGRQMSQQNLT 2431
Cdd:pfam05956   79 SSGSSRDSTPSRPPQKKLTSPSQSPGRLPGSGGRNKLSPLPKTKSPARASTKKSGS-------HKTQKSPVRIPFMQTPT 151

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431659 2432 KQTALTKNTSSI------PRSESASKGLNqilgsGASNKKTDLSRMSSAKSSGSESDRSerpVLVRQSTFIKEAPSPTLR 2505
Cdd:pfam05956  152 KQTGLPRNPSPLvtnqpePRSESASKGLR-----SLPGKRLDLVRMSSARSSGSESDRS---GFLRQLTFIKESPSLLLR 223

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431659 2506 RKLEESASfESLSP-SRPDSPTRSQlqtpvlsPSLPDMSLSTHSTAQTSGWRKLPPNLSPSVEY-DGRPAKRHDIARSHS 2583
Cdd:pfam05956  224 RRLELSAS-ESLSPsSQPASPRRSR-------PGLPAVFLCSSRCQELKGWRKQPPNPNSRAEPsDRPLTRRRPPRRTSS 295

                          330       340       350
                   ....*....|....*....|....*....|....*
gi 2024431659 2584 ESPSRLPInRSGTWKREHSKHSSSLPRVSTWRRTG 2618
Cdd:pfam05956  296 ESPSRLPV-RNGTWKRETFKRYSSLPHINVWRRTG 329
APC_u5 pfam16630
Unstructured region on APC between 1st and 2nd catenin-bdg motifs; APC_u5 is a short region of ...
 1092-1191 1.18e-56

Unstructured region on APC between 1st and 2nd catenin-bdg motifs; APC_u5 is a short region of natively unstructured sequence lying between the first and the second 15-residue beta-catenin binding motifs, APC_15aa, pfam05972, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 406923  Cd Length: 100  Bit Score: 191.66  E-value: 1.18e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431659 1092 LNSGRQSPSQNERWARPKHIIDDEMKQNDQRQSRSQSATYPVYTESGDDKHMKYQSPFGQQDCVPSFRSRGSNGSDQNRV 1171
Cdd:pfam16630    1 LNSGRQSPSQNERWARPKHIIEDEMKQSEQRQPRSQSTTYPVYTESGDDKHMKFQPRFGQQECVSPFRSRGSNGSEQSRV 80

                           90       100
                   ....*....|....*....|
gi 2024431659 1172 GSTLGINQKVNQSLCQVDDY 1191
Cdd:pfam16630   81 GSSHGINQKVSQSLCQVDDY 100
APC_u14 pfam16635
Unstructured region on APC between SAMP and APC_crr; APC_u14 is a short region of natively ...
 1804-1895 6.19e-48

Unstructured region on APC between SAMP and APC_crr; APC_u14 is a short region of natively unstructured sequence lying between the second SAMP pfam05924, and the fifth creatine-rich region, APC_crr, pfam05923, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 435479  Cd Length: 94  Bit Score: 166.55  E-value: 6.19e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431659 1804 IMDQIQQAST--SLNNKNQPEGEKKKPTSPVKPVPQNSEYRARVRKNTESKSQINNERSYPENRDAKKQNLKNNSRDFND 1881
Cdd:pfam16635    1 IMDQIQQASAasSGGSKSQQDGEKKKPTSPVKPMPQSSEYRARVRKNTESKNNLNSERSYPDNKESKKQNLKNNSRDFND 80

                           90
                   ....*....|....
gi 2024431659 1882 KLPNNEERVRGSFT 1895
Cdd:pfam16635   81 KLPNNEERTRGSFA 94
APC_rep pfam18797
Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo ...
 446-519 5.17e-44

Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo repeat and uses its highly conserved surface groove to recognize the APC-binding region (ABR) of Asef. This entry represents a single repeat unit of the Armadillo region.


Pssm-ID: 465870  Cd Length: 74  Bit Score: 154.63  E-value: 5.17e-44
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2024431659  446 SQPDDKRGRREIRVLHLLEQIRAYCETCWEWQEAHEQGMDQDKNPMPAPVDHQICPAVCVLMKLSFDEEHRHAM 519
Cdd:pfam18797    1 SQPDDKRGRREMRVLHLLEQIRAYCETCWDWQESHSRGPEGDSNPMPSPIEHQICPAICALMKLSFDEEHRHAM 74
APC_u9 pfam16633
Unstructured region on APC between 1st two creatine-rich regions; APC_u9 is a short region of ...
 1340-1426 4.75e-35

Unstructured region on APC between 1st two creatine-rich regions; APC_u9 is a short region of natively unstructured sequence lying between the first and second APC_crr, pfam05923, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 435478  Cd Length: 89  Bit Score: 129.61  E-value: 4.75e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431659 1340 AEDEI-GRDQSTRVTDTNATLQISELKENSGALSAEAAVSEITSTSQHIRTKSSRLPTSSLSPSESSRHKAVEFSSGAKS 1418
Cdd:pfam16633    2 AEDEIeGRDQATRSTDNYNTLQITELKENSGAVSTEQTVSEVPSSSQHIRTKPNRLQASNLSPSDSSRHKAVEFSSGAKS 81


                   ....*...
gi 2024431659 1419 PSKSGAQT 1426
Cdd:pfam16633   82 PSKSGAQT 89
APC_u15 pfam16636
Unstructured region on APC between APC_crr regions 5 and 6; APC_u15 is a short region of ...
 1929-1996 3.76e-27

Unstructured region on APC between APC_crr regions 5 and 6; APC_u15 is a short region of natively unstructured sequence lying between the fifth and sixth creatine-rich, APC_crr, pfam05923, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 435480  Cd Length: 81  Bit Score: 106.87  E-value: 3.76e-27
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2024431659 1929 DLSREKAELRKGKEAKEVETKDCPNVEQPSGQQPSNRTQVCQKHPTSRSQSK-------TFCQPSKDIPDRGAAT 1996
Cdd:pfam16636    7 DLSREKAELRKGKETKETETKVTSHIEQPSNQQSTNRTQACQKHPPNRGQPKpllqkqtTFPQSSKDIPDRGAAT 81
APC_u13 pfam16634
Unstructured region on APC between APC_crr and SAMP; APC_u13 is a short region of natively ...
 1720-1773 1.05e-26

Unstructured region on APC between APC_crr and SAMP; APC_u13 is a short region of natively unstructured sequence lying between the fourth creatine-rich region, APC_crr, pfam05923, and the SAMP pfam05924, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 406927  Cd Length: 54  Bit Score: 104.49  E-value: 1.05e-26
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2024431659 1720 IESPPNELANVDSVGAGAESGEFEKRDTIPTEGRSTDDTQRAKSITVTGPGLDD 1773
Cdd:pfam16634    1 IESPPNELANAESTGTGAESAEFEKRDTIPTEGRSTDDAQRGKKSNITTSALDD 54
APC_N_CC pfam16689
Coiled-coil N-terminus of APC, dimerization domain; APC_N_CC is the N-terminal, coiled-coil ...
 4-67 3.40e-19

Coiled-coil N-terminus of APC, dimerization domain; APC_N_CC is the N-terminal, coiled-coil dimerization domain of the adenomatosis polyposis coli (APC) tumour-repressor proteins. It plays a key role in the regulation of cellular levels of the oncogene product beta-catenin. Coiled-coil regions are binding repeats that in this case bind to the armadillo repeat region of beta-catenin.


Pssm-ID: 435517  Cd Length: 52  Bit Score: 83.11  E-value: 3.40e-19
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2024431659    4 ASYDQLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNMKmvdpagictyleEVLKQLQGSI 67
Cdd:pfam16689    1 ASYDQLLRQVEALKLENTTLRQELRDNSSHLSKLETEASNMK------------EVLKHLQGSI 52
Suppressor_APC pfam11414
Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has ...
 139-219 9.96e-13

Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has a nuclear export activity as well as many different intracellular functions. The structure consists of three alpha-helices forming two separate antiparallel coiled coils.


Pssm-ID: 463275  Cd Length: 82  Bit Score: 65.74  E-value: 9.96e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431659  139 SRESTGYLEELEKERSLLLAELEKEEKEKDWYYAQLQNLTKRIDSLPLTE-NFSLQTDMTRRQLEYEARQIRAAMEEQLG 217
Cdd:pfam11414    1 DYNMLKRMKQLEQEKDVLLQGLEMVERARDWYQQQLQEVQERQKYLGANGtYFDYGSDAQQERLEFLLARIQEVNRCLGG 80


                   ..
gi 2024431659  218 TC 219
Cdd:pfam11414   81 LI 82
APC_r pfam05923
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1695-1718 1.93e-07

APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.


Pssm-ID: 461781  Cd Length: 24  Bit Score: 48.92  E-value: 1.93e-07
                           10        20
                   ....*....|....*....|....
gi 2024431659 1695 DMPRVYCVEGTPINFSTATSLSDL 1718
Cdd:pfam05923    1 DSPKRYCVEGTPANFSRASSLSSL 24
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 702-742 2.48e-06

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 46.27  E-value: 2.48e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2024431659   702 NEDHRQILRENSCLQTLLQHLKSHSLTIVSNACGTLWNLSA 742
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 702-742 3.24e-06

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 45.91  E-value: 3.24e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2024431659  702 NEDHRQILRENSCLQTLLQHLKSHSLTIVSNACGTLWNLSA 742
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
SAMP pfam05924
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis ...
 2083-2102 4.21e-05

SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). This motif binds axin.


Pssm-ID: 461782  Cd Length: 22  Bit Score: 42.58  E-value: 4.21e-05
                           10        20
                   ....*....|....*....|
gi 2024431659 2083 DSEDDLLQECISSAMPKKKK 2102
Cdd:pfam05924    3 DDEDDLLQECINSAMPKKRR 22
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 565-606 5.35e-04

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 39.72  E-value: 5.35e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2024431659   565 DVANKATLCSMkGCMRALVAQLKSESEDLQQVIASVLRNLSW 606
Cdd:smart00185    1 DDENKQAVVDA-GGLPALVELLKSEDEEVVKEAAWALSNLSS 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 565-605 6.15e-04

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 39.36  E-value: 6.15e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2024431659  565 DVANKATLCSMkGCMRALVAQLKSESEDLQQVIASVLRNLS 605
Cdd:pfam00514    1 SPENKQAVIEA-GAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 393-445 1.59e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 38.56  E-value: 1.59e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 2024431659   393 SQDSCIAMRQSGCLPLLIQLLHgndkdsvllgnsRGSKEARARASAALHNIIH 445
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLK------------SEDEEVVKEAAWALSNLSS 41
PHA03247 PHA03247
large tegument protein UL36; Provisional
 2301-2614 2.28e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 2.28e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431659 2301 PPFKNTNSKSPSEGQSSASSPRGVKSSVKPEPAPVTRQLSGLNQGGSSK--GPSRSGSRDSTPSRPQQQPLSRPLQSPGR 2378
Cdd:PHA03247  2702 PPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATpgGPARPARPPTTAGPPAPAPPAAPAAGPPR 2781

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431659 2379 NSISPGRNGISPPNKLSQLPRTSSPSTASTKSSSSGRMSYTSPGRQMSQQNLTKQTALTKNTSSIPRSESASkglnqilg 2458
Cdd:PHA03247  2782 RLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLG-------- 2853

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431659 2459 sGASNKKTDLSRMSSAKSSGSESDRSERPVLVR-------QSTFIKEAPSPTLRRKLEESASFESLSPSRPDSPTRSQLQ 2531
Cdd:PHA03247  2854 -GSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRlarpavsRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPP 2932

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431659 2532 TPvlSPSLPDMSLS-THSTAQTSGWRKLPPNLSPSVEYDGR-PAKRhdiARSHSESPSRlPINRSGTwkreHSKHSSSLP 2609
Cdd:PHA03247  2933 PP--PPPRPQPPLApTTDPAGAGEPSGAVPQPWLGALVPGRvAVPR---FRVPQPAPSR-EAPASST----PPLTGHSLS 3002


                   ....*
gi 2024431659 2610 RVSTW 2614
Cdd:PHA03247  3003 RVSSW 3007
SAMP pfam05924
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1774-1795 2.46e-03

SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). This motif binds axin.


Pssm-ID: 461782  Cd Length: 22  Bit Score: 37.57  E-value: 2.46e-03
                           10        20
                   ....*....|....*....|..
gi 2024431659 1774 DKTEEGDILAECINSAMPKGKS 1795
Cdd:pfam05924    1 SPDDEDDLLQECINSAMPKKRR 22
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 744-784 2.51e-03

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 37.82  E-value: 2.51e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2024431659  744 NAKDQEALWDMGAVSMLKNLIHSKHKMIAMGSAAALRNLMA 784
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 2308-2616 2.91e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 43.14  E-value: 2.91e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431659 2308 SKSPSEGQSSASSPRGVKSSvKPEPA--------PV-TRQLSGLNQGGSSKGPS--RSGSRDSTPSRPQQQP------LS 2370
Cdd:PTZ00449   540 SDEPKEGGKPGETKEGEVGK-KPGPAkehkpskiPTlSKKPEFPKDPKHPKDPEepKKPKRPRSAQRPTRPKspklpeLL 618

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431659 2371 RPLQSPGR-NSISPGRNGISPPNKLSQLPRTSSPSTASTKSSSSGRMSYTSPGRQMSQQNLTKQTALTKNT-SSIPRSES 2448
Cdd:PTZ00449   619 DIPKSPKRpESPKSPKRPPPPQRPSSPERPEGPKIIKSPKPPKSPKPPFDPKFKEKFYDDYLDAAAKSKETkTTVVLDES 698

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431659 2449 ASKGLNQILGSGASNKKTD-------LSRMSSAKSSGSESDRSERP-------VLVRQSTFIKEAPSPTLRRKL------ 2508
Cdd:PTZ00449   699 FESILKETLPETPGTPFTTprplppkLPRDEEFPFEPIGDPDAEQPddiefftPPEEERTFFHETPADTPLPDIlaeefk 778

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431659 2509 EESASFESLSPS----RPDSPTRSQLQTPVLSPSLP-------DMSLSThSTAQTSGWRKL------PPNLSPSVEYDGR 2571
Cdd:PTZ00449   779 EEDIHAETGEPDeamkRPDSPSEHEDKPPGDHPSLPkkrhrldGLALST-TDLESDAGRIAkdasgkIVKLKRSKSFDDL 857

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*
gi 2024431659 2572 PAKRhdIARSHSESPSRLPINRSGTWKREHSKHSSSLPRVSTWRR 2616
Cdd:PTZ00449   858 TTVE--EAEEMGAEARKIVVDDDGTEADDEDTHPPEEKHKSEVRR 900
APC_r pfam05923
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1429-1451 4.42e-03

APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.


Pssm-ID: 461781  Cd Length: 24  Bit Score: 36.59  E-value: 4.42e-03
                           10        20
                   ....*....|....*....|....
gi 2024431659 1429 SPPEHY-VQETPLMFSRCTSVSSL 1451
Cdd:pfam05923    1 DSPKRYcVEGTPANFSRASSLSSL 24
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 512-563 5.04e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 37.02  E-value: 5.04e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 2024431659   512 DEEHRHAMNELGGLQAIAELLQvdcemygltndHYSVTLRRYAGMALTNLTF 563
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLK-----------SEDEEVVKEAAWALSNLSS 41
APC_r pfam05923
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1314-1331 8.29e-03

APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.


Pssm-ID: 461781  Cd Length: 24  Bit Score: 35.82  E-value: 8.29e-03
                           10
                   ....*....|....*...
gi 2024431659 1314 ETIQTYCVEDTPICFSRC 1331
Cdd:pfam05923    1 DSPKRYCVEGTPANFSRA 18
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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