NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2027918103|ref|XP_040801416|]
View 

amine oxidase, flavin-containing superfamily [Aspergillus fijiensis CBS 313.89]

Protein Classification

NAD(P)/FAD-dependent oxidoreductase( domain architecture ID 13383666)

NAD(P)/FAD-dependent oxidoreductase which catalyzes the transfer of electrons from one molecule, the electron donor or reductant, to another molecule, the electron acceptor or oxidant

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
NAD_binding_8 pfam13450
NAD(P)-binding Rossmann-like domain;
49-115 2.57e-15

NAD(P)-binding Rossmann-like domain;


:

Pssm-ID: 433218 [Multi-domain]  Cd Length: 67  Bit Score: 70.25  E-value: 2.57e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2027918103  49 IIGGGSAGTYAAIRLRQMNYSVVVIEKEDHLGGHVNTYTEPttGIAADYGVLYF--EDEPWVRDYFAYL 115
Cdd:pfam13450   1 IVGAGLAGLVAAALLAKRGFRVLVLEKRDRLGGNAYSYRVP--GYVFDYGAHIFhgSDEPNVRDLLDEL 67
YobN super family cl34196
Monoamine oxidase [Amino acid transport and metabolism];
45-434 4.51e-12

Monoamine oxidase [Amino acid transport and metabolism];


The actual alignment was detected with superfamily member COG1231:

Pssm-ID: 440844 [Multi-domain]  Cd Length: 440  Bit Score: 67.64  E-value: 4.51e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027918103  45 RDVAIIGGGSAGTYAAIRLRQMNYSVVVIEKEDHLGGHVNTYTEPTTGIAADYGVLYF-EDEPWVRDYFAYLHVPVVKVS 123
Cdd:COG1231     8 KDVVIVGAGLAGLAAARELRKAGLDVTVLEARDRVGGRVWTLRFGDDGLYAELGAMRIpPSHTNLLALARELGLPLEPFP 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027918103 124 -VLGQGVM----RRVDMRTGASVPLSDGTTIPAMAAYAAQLLKypylntgfNLPDPVPEDLLLPFGEFIRKY-NLDGAVD 197
Cdd:COG1231    88 nENGNALLylggKRVRAGEIAADLRGVAELLAKLLRALAAALD--------PWAHPAAELDRESLAEWLRRNgASPSARR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027918103 198 IIALFNQGV--GDLLQQLTLYMMKYFSLGVLRDA----IGGflqpashsNSELYGAAQRELGGDALFSSTVTATNRDDGg 271
Cdd:COG1231   160 LLGLLGAGEygADPDELSLLDLLRYAASAGGGAQqfriVGG--------MDQLPRALAAELGDRIRLGAPVTRIRQDGD- 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027918103 272 eggeddwiHLQTRTPSGEqTIQAKKLIVAIQPKLenLAAIDLDPTERDLFGQFHNTNYYTSLAHV-----------PGLP 340
Cdd:COG1231   231 --------GVTVTTDDGG-TVRADAVIVTVPPSV--LRRIEFDPPLPAAKRAAIQRLPYGAAIKVflqfdrpfweeDGLY 299

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027918103 341 VGSLIlnraTDTPYHLppqpAVYVMRPTQSPN--LTSILYGS----VDHMSEEEVKRHMTQSVLQLRhagiPVQAPEFVA 414
Cdd:COG1231   300 GGISL----TDLPIRQ----TWYPSNGPDGGAgvLLGYVGGDdaraLAALSPEERVAAALEQLARIF----GVYAAEPVD 367

                         410       420
                  ....*....|....*....|....
gi 2027918103 415 YSDH----VPFlltvsadaIRGGF 434
Cdd:COG1231   368 YVSTdwgrDPW--------SRGAY 383
 
Name Accession Description Interval E-value
NAD_binding_8 pfam13450
NAD(P)-binding Rossmann-like domain;
49-115 2.57e-15

NAD(P)-binding Rossmann-like domain;


Pssm-ID: 433218 [Multi-domain]  Cd Length: 67  Bit Score: 70.25  E-value: 2.57e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2027918103  49 IIGGGSAGTYAAIRLRQMNYSVVVIEKEDHLGGHVNTYTEPttGIAADYGVLYF--EDEPWVRDYFAYL 115
Cdd:pfam13450   1 IVGAGLAGLVAAALLAKRGFRVLVLEKRDRLGGNAYSYRVP--GYVFDYGAHIFhgSDEPNVRDLLDEL 67
YobN COG1231
Monoamine oxidase [Amino acid transport and metabolism];
45-434 4.51e-12

Monoamine oxidase [Amino acid transport and metabolism];


Pssm-ID: 440844 [Multi-domain]  Cd Length: 440  Bit Score: 67.64  E-value: 4.51e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027918103  45 RDVAIIGGGSAGTYAAIRLRQMNYSVVVIEKEDHLGGHVNTYTEPTTGIAADYGVLYF-EDEPWVRDYFAYLHVPVVKVS 123
Cdd:COG1231     8 KDVVIVGAGLAGLAAARELRKAGLDVTVLEARDRVGGRVWTLRFGDDGLYAELGAMRIpPSHTNLLALARELGLPLEPFP 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027918103 124 -VLGQGVM----RRVDMRTGASVPLSDGTTIPAMAAYAAQLLKypylntgfNLPDPVPEDLLLPFGEFIRKY-NLDGAVD 197
Cdd:COG1231    88 nENGNALLylggKRVRAGEIAADLRGVAELLAKLLRALAAALD--------PWAHPAAELDRESLAEWLRRNgASPSARR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027918103 198 IIALFNQGV--GDLLQQLTLYMMKYFSLGVLRDA----IGGflqpashsNSELYGAAQRELGGDALFSSTVTATNRDDGg 271
Cdd:COG1231   160 LLGLLGAGEygADPDELSLLDLLRYAASAGGGAQqfriVGG--------MDQLPRALAAELGDRIRLGAPVTRIRQDGD- 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027918103 272 eggeddwiHLQTRTPSGEqTIQAKKLIVAIQPKLenLAAIDLDPTERDLFGQFHNTNYYTSLAHV-----------PGLP 340
Cdd:COG1231   231 --------GVTVTTDDGG-TVRADAVIVTVPPSV--LRRIEFDPPLPAAKRAAIQRLPYGAAIKVflqfdrpfweeDGLY 299

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027918103 341 VGSLIlnraTDTPYHLppqpAVYVMRPTQSPN--LTSILYGS----VDHMSEEEVKRHMTQSVLQLRhagiPVQAPEFVA 414
Cdd:COG1231   300 GGISL----TDLPIRQ----TWYPSNGPDGGAgvLLGYVGGDdaraLAALSPEERVAAALEQLARIF----GVYAAEPVD 367

                         410       420
                  ....*....|....*....|....
gi 2027918103 415 YSDH----VPFlltvsadaIRGGF 434
Cdd:COG1231   368 YVSTdwgrDPW--------SRGAY 383
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
 46-111 6.81e-09

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 57.57  E-value: 6.81e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2027918103  46 DVAIIGGGSAGTYAAIRLRQMNYSVVVIEKEDHLGG--HVNTYtePttGIAAD-----YGvlyFEDEPWVRDY 111
Cdd:COG2072     8 DVVVIGAGQAGLAAAYHLRRAGIDFVVLEKADDVGGtwRDNRY--P--GLRLDtpshlYS---LPFFPNWSDD 73
PRK06292 PRK06292
dihydrolipoamide dehydrogenase; Validated
 46-81 1.77e-08

dihydrolipoamide dehydrogenase; Validated


Pssm-ID: 235774 [Multi-domain]  Cd Length: 460  Bit Score: 56.72  E-value: 1.77e-08
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2027918103  46 DVAIIGGGSAGTYAAIRLRQMNYSVVVIEKeDHLGG 81
Cdd:PRK06292    5 DVIVIGAGPAGYVAARRAAKLGKKVALIEK-GPLGG 39
 
Name Accession Description Interval E-value
NAD_binding_8 pfam13450
NAD(P)-binding Rossmann-like domain;
49-115 2.57e-15

NAD(P)-binding Rossmann-like domain;


Pssm-ID: 433218 [Multi-domain]  Cd Length: 67  Bit Score: 70.25  E-value: 2.57e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2027918103  49 IIGGGSAGTYAAIRLRQMNYSVVVIEKEDHLGGHVNTYTEPttGIAADYGVLYF--EDEPWVRDYFAYL 115
Cdd:pfam13450   1 IVGAGLAGLVAAALLAKRGFRVLVLEKRDRLGGNAYSYRVP--GYVFDYGAHIFhgSDEPNVRDLLDEL 67
YobN COG1231
Monoamine oxidase [Amino acid transport and metabolism];
45-434 4.51e-12

Monoamine oxidase [Amino acid transport and metabolism];


Pssm-ID: 440844 [Multi-domain]  Cd Length: 440  Bit Score: 67.64  E-value: 4.51e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027918103  45 RDVAIIGGGSAGTYAAIRLRQMNYSVVVIEKEDHLGGHVNTYTEPTTGIAADYGVLYF-EDEPWVRDYFAYLHVPVVKVS 123
Cdd:COG1231     8 KDVVIVGAGLAGLAAARELRKAGLDVTVLEARDRVGGRVWTLRFGDDGLYAELGAMRIpPSHTNLLALARELGLPLEPFP 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027918103 124 -VLGQGVM----RRVDMRTGASVPLSDGTTIPAMAAYAAQLLKypylntgfNLPDPVPEDLLLPFGEFIRKY-NLDGAVD 197
Cdd:COG1231    88 nENGNALLylggKRVRAGEIAADLRGVAELLAKLLRALAAALD--------PWAHPAAELDRESLAEWLRRNgASPSARR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027918103 198 IIALFNQGV--GDLLQQLTLYMMKYFSLGVLRDA----IGGflqpashsNSELYGAAQRELGGDALFSSTVTATNRDDGg 271
Cdd:COG1231   160 LLGLLGAGEygADPDELSLLDLLRYAASAGGGAQqfriVGG--------MDQLPRALAAELGDRIRLGAPVTRIRQDGD- 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027918103 272 eggeddwiHLQTRTPSGEqTIQAKKLIVAIQPKLenLAAIDLDPTERDLFGQFHNTNYYTSLAHV-----------PGLP 340
Cdd:COG1231   231 --------GVTVTTDDGG-TVRADAVIVTVPPSV--LRRIEFDPPLPAAKRAAIQRLPYGAAIKVflqfdrpfweeDGLY 299

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027918103 341 VGSLIlnraTDTPYHLppqpAVYVMRPTQSPN--LTSILYGS----VDHMSEEEVKRHMTQSVLQLRhagiPVQAPEFVA 414
Cdd:COG1231   300 GGISL----TDLPIRQ----TWYPSNGPDGGAgvLLGYVGGDdaraLAALSPEERVAAALEQLARIF----GVYAAEPVD 367

                         410       420
                  ....*....|....*....|....
gi 2027918103 415 YSDH----VPFlltvsadaIRGGF 434
Cdd:COG1231   368 YVSTdwgrDPW--------SRGAY 383
COG1233 COG1233
Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and ...
 45-443 8.46e-10

Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440846 [Multi-domain]  Cd Length: 491  Bit Score: 60.63  E-value: 8.46e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027918103  45 RDVAIIGGGSAGTYAAIRLRQMNYSVVVIEKEDHLGGHVNTYTEPttGIAADYGVLYFEDEPWVRDYFAYLhvpvvkvsv 124
Cdd:COG1233     4 YDVVVIGAGIGGLAAAALLARAGYRVTVLEKNDTPGGRARTFERP--GFRFDVGPSVLTMPGVLERLFREL--------- 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027918103 125 lgqGVMRRVDMR---TGASVPLSDGTTIPA---MAAYAAQLLKY---------PYLNTGFNLPDPVPEDLLL-PFGEFIR 188
Cdd:COG1233    73 ---GLEDYLELVpldPAYRVPFPDGRALDLprdLERTAAELERLfpgdaeayrRFLAELRRLYDALLEDLLYrPLLSLRD 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027918103 189 KYNLDGAVDIIALFNQGVGDLLQqltlymmKYFSLGVLR---DAIGGFLQPASHSNSELYGAAQ---------------- 249
Cdd:COG1233   150 LLRPLALARLLRLLLRSLRDLLR-------RYFKDPRLRallAGQALYLGLSPDRTPALYALIAyleyaggvwypkggmg 222

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027918103 250 ----------RELGGDALFSSTVTAtnrddggeggeddwIHLQT------RTPSGEqTIQAKKLIvaiqpklenlAAIDL 313
Cdd:COG1233   223 aladalarlaEELGGEIRTGAEVER--------------ILVEGgratgvRLADGE-EIRADAVV----------SNADP 277

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027918103 314 DPTERDLFGQFHNTNYYTSL------------------AHVPGLPVGSLILNRATDTPYH------LPPQPAVYVMRPT- 368
Cdd:COG1233   278 AHTYLRLLGEEALPARYRRRlerfryspsafklylgldGPLPGLAHHTIHLSEDYEAAFDdifrgrLPEDPSLYVSIPSl 357

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027918103 369 ----QSP----NLTsiLYGSVDHMSE---EEVKRHMTQSVLQL--RHagipvqAPEFvaySDHVPFLLTVSADAIRggfy 435
Cdd:COG1233   358 tdpsLAPegkhTLW--VLVPVPYGLEdawDELKEEYAERILARleRY------APGL---RDRIVAREVLTPLDFE---- 422


                  ....*...
gi 2027918103 436 RELNALQG 443
Cdd:COG1233   423 RYLNLVGG 430
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
 46-111 6.81e-09

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 57.57  E-value: 6.81e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2027918103  46 DVAIIGGGSAGTYAAIRLRQMNYSVVVIEKEDHLGG--HVNTYtePttGIAAD-----YGvlyFEDEPWVRDY 111
Cdd:COG2072     8 DVVVIGAGQAGLAAAYHLRRAGIDFVVLEKADDVGGtwRDNRY--P--GLRLDtpshlYS---LPFFPNWSDD 73
PRK06292 PRK06292
dihydrolipoamide dehydrogenase; Validated
 46-81 1.77e-08

dihydrolipoamide dehydrogenase; Validated


Pssm-ID: 235774 [Multi-domain]  Cd Length: 460  Bit Score: 56.72  E-value: 1.77e-08
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2027918103  46 DVAIIGGGSAGTYAAIRLRQMNYSVVVIEKeDHLGG 81
Cdd:PRK06292    5 DVIVIGAGPAGYVAARRAAKLGKKVALIEK-GPLGG 39
Lpd COG1249
Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex ...
 46-81 2.35e-08

Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase [Energy production and conversion]; Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase is part of the Pathway/BioSystem: Glycine cleavagePyruvate oxidation


Pssm-ID: 440861 [Multi-domain]  Cd Length: 456  Bit Score: 56.25  E-value: 2.35e-08
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2027918103  46 DVAIIGGGSAGTYAAIRLRQMNYSVVVIEKeDHLGG 81
Cdd:COG1249     5 DLVVIGAGPGGYVAAIRAAQLGLKVALVEK-GRLGG 39
HdrA COG1148
Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];
37-97 1.06e-07

Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];


Pssm-ID: 440762 [Multi-domain]  Cd Length: 563  Bit Score: 54.10  E-value: 1.06e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2027918103  37 PESQQSIIRDVAIIGGGSAGTYAAIRLRQMNYSVVVIEKEDHLGGHVNTY--TEPTTGIAADY 97
Cdd:COG1148   133 EPIKVPVNKRALVIGGGIAGMTAALELAEQGYEVYLVEKEPELGGRAAQLhkTFPGLDCPQCI 195
HemY COG1232
Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen ...
 45-354 1.38e-07

Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen oxidase HemY/PPOX is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 440845 [Multi-domain]  Cd Length: 443  Bit Score: 53.68  E-value: 1.38e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027918103  45 RDVAIIGGGSAGTYAAIRLRQMNYSVVVIEKEDHLGGHVNTYTEPttGIAADYGV-LYFEDEPWVRDYFAYLHVP--VVK 121
Cdd:COG1232     2 KRVAVIGGGIAGLTAAYRLAKAGHEVTVLEASDRVGGLIRTVEVD--GFRIDRGPhSFLTRDPEVLELLRELGLGdeLVW 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027918103 122 VSvlgqGVMRRVdmrtgasvpLSDGTTIPaMAAYAAQLLKYPYLNTG---------FNLPDPVPEDllLPFGEFIRKYNL 192
Cdd:COG1232    80 PN----TRKSYI---------YYGGKLHP-LPQGPLALLRSPLLSLAgklrallelLAPRRPPGED--ESLAEFVRRRFG 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027918103 193 DGAVDIIAL-FNQGV--GDL--------LQQLTLYMMKYFSL--GVLR----DAIGGFLQPASHSNSELYGAAQRELG-G 254
Cdd:COG1232   144 REVYERLVEpLLEGVyaGDPdelsadwaFPRLKRLELEHGSLikGALAlrkgAKAGEVFGYLRGGLGTLVEALAEALEaG 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027918103 255 DALFSSTVTATNRDDGgeggeddwiHLQTRTPSGEqTIQAKKLIVAIQ-PKLENLAAiDLDPTERDLFGQFHntnyYTSL 333
Cdd:COG1232   224 EIRLGTRVTAIEREGG---------GWRVTTSDGE-TIEADAVVSATPaPALARLLA-PLPPEVAAALAGIP----YASV 288

                         330       340
                  ....*....|....*....|.
gi 2027918103 334 AHVpglpvgSLILNRATDTPY 354
Cdd:COG1232   289 AVV------ALGFDRPDLPPP 303
PRK11749 PRK11749
dihydropyrimidine dehydrogenase subunit A; Provisional
 47-95 1.96e-07

dihydropyrimidine dehydrogenase subunit A; Provisional


Pssm-ID: 236967 [Multi-domain]  Cd Length: 457  Bit Score: 53.26  E-value: 1.96e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2027918103  47 VAIIGGGSAGTYAAIRLRQMNYSVVVIEKEDHLGGhVNTYtepttGIAA 95
Cdd:PRK11749  143 VAVIGAGPAGLTAAHRLARKGYDVTIFEARDKAGG-LLRY-----GIPE 185
SdhA COG1053
Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and ...
 46-82 1.98e-07

Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440673 [Multi-domain]  Cd Length: 443  Bit Score: 53.30  E-value: 1.98e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2027918103  46 DVAIIGGGSAGTYAAIRLRQMNYSVVVIEKEDHLGGH 82
Cdd:COG1053     5 DVVVVGSGGAGLRAALEAAEAGLKVLVLEKVPPRGGH 41
GltD COG0493
NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport ...
 47-95 2.16e-07

NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport and metabolism, General function prediction only]; NADPH-dependent glutamate synthase beta chain or related oxidoreductase is part of the Pathway/BioSystem: Glutamine biosynthesis


Pssm-ID: 440259 [Multi-domain]  Cd Length: 434  Bit Score: 53.22  E-value: 2.16e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2027918103  47 VAIIGGGSAGTYAAIRLRQMNYSVVVIEKEDHLGGhVNTYtepttGIAA 95
Cdd:COG0493   124 VAVVGSGPAGLAAAYQLARAGHEVTVFEALDKPGG-LLRY-----GIPE 166
Pyr_redox_2 pfam07992
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 46-79 6.78e-07

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 400379 [Multi-domain]  Cd Length: 301  Bit Score: 50.78  E-value: 6.78e-07
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2027918103  46 DVAIIGGGSAGTYAAIRLRQMNYSVVVIEKEDHL 79
Cdd:pfam07992   2 DVVVIGGGPAGLAAALTLAQLGGKVTLIEDEGTC 35
Ppro0129 COG2907
Predicted flavin-containing amine oxidase [General function prediction only];
45-121 1.21e-06

Predicted flavin-containing amine oxidase [General function prediction only];


Pssm-ID: 442151 [Multi-domain]  Cd Length: 423  Bit Score: 50.50  E-value: 1.21e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2027918103  45 RDVAIIGGGSAGTYAAIRLRQmNYSVVVIEKEDHLGGHVNTYTEPTTG--IAADYGVLYFEDepwvRDY------FAYLH 116
Cdd:COG2907     4 MRIAVIGSGISGLTAAWLLSR-RHDVTLFEANDRLGGHTHTVDVDLDGrtVPVDTGFIVFNE----RTYpnltalFAELG 78


                  ....*
gi 2027918103 117 VPVVK 121
Cdd:COG2907    79 VPTQP 83
FAD_oxidored pfam12831
FAD dependent oxidoreductase; This family of proteins contains FAD dependent oxidoreductases ...
 46-81 3.16e-06

FAD dependent oxidoreductase; This family of proteins contains FAD dependent oxidoreductases and related proteins.


Pssm-ID: 432816 [Multi-domain]  Cd Length: 420  Bit Score: 49.14  E-value: 3.16e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2027918103  46 DVAIIGGGSAGTYAAIRLRQMNYSVVVIEKEDHLGG 81
Cdd:pfam12831   1 DVVVVGGGPAGVAAAIAAARAGAKVLLVERRGFLGG 36
PRK06416 PRK06416
dihydrolipoamide dehydrogenase; Reviewed
 46-81 6.26e-06

dihydrolipoamide dehydrogenase; Reviewed


Pssm-ID: 235798 [Multi-domain]  Cd Length: 462  Bit Score: 48.60  E-value: 6.26e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2027918103  46 DVAIIGGGSAGTYAAIRLRQMNYSVVVIEKeDHLGG 81
Cdd:PRK06416    6 DVIVIGAGPGGYVAAIRAAQLGLKVAIVEK-EKLGG 40
PRK07208 PRK07208
hypothetical protein; Provisional
 45-81 9.54e-06

hypothetical protein; Provisional


Pssm-ID: 235967 [Multi-domain]  Cd Length: 479  Bit Score: 47.96  E-value: 9.54e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2027918103  45 RDVAIIGGGSAGTYAAIRLRQMNYSVVVIEKEDHLGG 81
Cdd:PRK07208    5 KSVVIIGAGPAGLTAAYELLKRGYPVTVLEADPVVGG 41
COG3349 COG3349
Uncharacterized protein, contains NAD-binding domain and a Fe-S cluster [General function ...
 45-98 1.25e-05

Uncharacterized protein, contains NAD-binding domain and a Fe-S cluster [General function prediction only];


Pssm-ID: 442577 [Multi-domain]  Cd Length: 445  Bit Score: 47.54  E-value: 1.25e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2027918103  45 RDVAIIGGGSAGTYAAIRLRQMNYSVVVIEKEDHLGGHVNTYTEPTTGIAADYG 98
Cdd:COG3349     4 PRVVVVGGGLAGLAAAVELAEAGFRVTLLEARPRLGGRARSFPDPDTGLPIDNG 57
DAO pfam01266
FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: ...
 46-82 1.48e-05

FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.


Pssm-ID: 426168 [Multi-domain]  Cd Length: 339  Bit Score: 47.01  E-value: 1.48e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2027918103  46 DVAIIGGGSAGTYAAIRLRQMNYSVVVIEKEDHLGGH 82
Cdd:pfam01266   1 DVVVIGGGIVGLSTAYELARRGLSVTLLERGDDPGSG 37
TrxB COG0492
Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];
46-88 1.58e-05

Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440258 [Multi-domain]  Cd Length: 305  Bit Score: 46.65  E-value: 1.58e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2027918103  46 DVAIIGGGSAGTYAAIRLRQMNYSVVVIEKeDHLGGHVNTYTE 88
Cdd:COG0492     2 DVVIIGAGPAGLTAAIYAARAGLKTLVIEG-GEPGGQLATTKE 43
DadA COG0665
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
45-77 2.10e-05

Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];


Pssm-ID: 440429 [Multi-domain]  Cd Length: 364  Bit Score: 46.44  E-value: 2.10e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 2027918103  45 RDVAIIGGGSAGTYAAIRLRQMNYSVVVIEKED 77
Cdd:COG0665     3 ADVVVIGGGIAGLSTAYHLARRGLDVTVLERGR 35
FAD_binding_2 pfam00890
FAD binding domain; This family includes members that bind FAD. This family includes the ...
 46-82 2.14e-05

FAD binding domain; This family includes members that bind FAD. This family includes the flavoprotein subunits from succinate and fumarate dehydrogenase, aspartate oxidase and the alpha subunit of adenylylsulphate reductase.


Pssm-ID: 395718 [Multi-domain]  Cd Length: 398  Bit Score: 46.51  E-value: 2.14e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2027918103  46 DVAIIGGGSAGTYAAIRLRQMNYSVVVIEKEDHLGGH 82
Cdd:pfam00890   1 DVLVIGGGLAGLAAALAAAEAGLKVAVVEKGQPFGGA 37
HI0933_like pfam03486
HI0933-like protein;
45-80 3.66e-05

HI0933-like protein;


Pssm-ID: 427330 [Multi-domain]  Cd Length: 406  Bit Score: 46.03  E-value: 3.66e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2027918103  45 RDVAIIGGGSAGTYAAIRLRQMNYSVVVIEKEDHLG 80
Cdd:pfam03486   1 FDVIVIGGGAAGLMAAISAAKRGRRVLLIEKGKKLG 36
FixC COG0644
Dehydrogenase (flavoprotein) [Energy production and conversion];
52-83 1.73e-04

Dehydrogenase (flavoprotein) [Energy production and conversion];


Pssm-ID: 440409 [Multi-domain]  Cd Length: 281  Bit Score: 43.42  E-value: 1.73e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 2027918103  52 GGSAGTYAAIRLRQMNYSVVVIEKEDHLGGHV 83
Cdd:COG0644     1 AGPAGSAAARRLARAGLSVLLLEKGSFPGDKI 32
LhgO COG0579
L-2-hydroxyglutarate oxidase LhgO [Carbohydrate transport and metabolism];
46-83 2.37e-04

L-2-hydroxyglutarate oxidase LhgO [Carbohydrate transport and metabolism];


Pssm-ID: 440344 [Multi-domain]  Cd Length: 418  Bit Score: 43.21  E-value: 2.37e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2027918103  46 DVAIIGGGSAGTYAAIRL-RQMNYSVVVIEKEDHLGGHV 83
Cdd:COG0579     6 DVVIIGAGIVGLALARELsRYEDLKVLVLEKEDDVAQES 44
PRK11883 PRK11883
protoporphyrinogen oxidase; Reviewed
 47-86 3.32e-04

protoporphyrinogen oxidase; Reviewed


Pssm-ID: 237009 [Multi-domain]  Cd Length: 451  Bit Score: 42.91  E-value: 3.32e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2027918103  47 VAIIGGGSAGTYAAIRLRQ--MNYSVVVIEKEDHLGGHVNTY 86
Cdd:PRK11883    3 VAIIGGGITGLSAAYRLHKkgPDADITLLEASDRLGGKIQTV 44
YdhS COG4529
Uncharacterized NAD(P)/FAD-binding protein YdhS [General function prediction only];
41-80 3.71e-04

Uncharacterized NAD(P)/FAD-binding protein YdhS [General function prediction only];


Pssm-ID: 443597 [Multi-domain]  Cd Length: 466  Bit Score: 43.02  E-value: 3.71e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2027918103  41 QSIIRDVAIIGGGSAGTYAAIRL---RQMNYSVVVIEKEDHLG 80
Cdd:COG4529     2 TGARKRIAIIGGGASGTALAIHLlrrAPEPLRITLFEPRPELG 44
PRK12842 PRK12842
putative succinate dehydrogenase; Reviewed
 46-81 4.09e-04

putative succinate dehydrogenase; Reviewed


Pssm-ID: 237224 [Multi-domain]  Cd Length: 574  Bit Score: 42.76  E-value: 4.09e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2027918103  46 DVAIIGGGSAGTYAAIRLRQMNYSVVVIEKEDHLGG 81
Cdd:PRK12842   11 DVLVIGSGAGGLSAAITARKLGLDVVVLEKEPVFGG 46
PRK12771 PRK12771
putative glutamate synthase (NADPH) small subunit; Provisional
 47-81 5.02e-04

putative glutamate synthase (NADPH) small subunit; Provisional


Pssm-ID: 237198 [Multi-domain]  Cd Length: 564  Bit Score: 42.55  E-value: 5.02e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2027918103  47 VAIIGGGSAGTYAAIRLRQMNYSVVVIEKEDHLGG 81
Cdd:PRK12771  140 VAVIGGGPAGLSAAYHLRRMGHAVTIFEAGPKLGG 174
PRK06370 PRK06370
FAD-containing oxidoreductase;
46-99 5.91e-04

FAD-containing oxidoreductase;


Pssm-ID: 235787 [Multi-domain]  Cd Length: 463  Bit Score: 42.11  E-value: 5.91e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2027918103  46 DVAIIGGGSAGTYAAIRLRQMNYSVVVIEKeDHLGGH-VNTYTEPTTGI------------AADYGV 99
Cdd:PRK06370    7 DAIVIGAGQAGPPLAARAAGLGMKVALIER-GLLGGTcVNTGCVPTKTLiasaraahlarrAAEYGV 72
gltD PRK12810
glutamate synthase subunit beta; Reviewed
 47-95 6.23e-04

glutamate synthase subunit beta; Reviewed


Pssm-ID: 237213 [Multi-domain]  Cd Length: 471  Bit Score: 42.07  E-value: 6.23e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2027918103  47 VAIIGGGSAGTYAAIRLRQMNYSVVVIEKEDHLGGhVNTYtepttGIAA 95
Cdd:PRK12810  146 VAVVGSGPAGLAAADQLARAGHKVTVFERADRIGG-LLRY-----GIPD 188
PRK07233 PRK07233
hypothetical protein; Provisional
 47-81 6.83e-04

hypothetical protein; Provisional


Pssm-ID: 235977 [Multi-domain]  Cd Length: 434  Bit Score: 41.80  E-value: 6.83e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2027918103  47 VAIIGGGSAGTYAAIRLRQMNYSVVVIEKEDHLGG 81
Cdd:PRK07233    2 IAIVGGGIAGLAAAYRLAKRGHEVTVFEADDQLGG 36
UbiH COG0654
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme ...
 45-82 7.13e-04

2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 440419 [Multi-domain]  Cd Length: 326  Bit Score: 41.46  E-value: 7.13e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2027918103  45 RDVAIIGGGSAGTYAAIRLRQMNYSVVVIEKEDHLGGH 82
Cdd:COG0654     4 TDVLIVGGGPAGLALALALARAGIRVTVVERAPPPRPD 41
mnmC PRK01747
bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent ...
 12-77 7.19e-04

bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent 5-carboxymethylaminomethyl-2-thiouridine(34) oxidoreductase MnmC;


Pssm-ID: 234978 [Multi-domain]  Cd Length: 662  Bit Score: 42.14  E-value: 7.19e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2027918103  12 ILQAALCLQATHARPDAW-TRSNSSWPesqqsiiRDVAIIGGGSAGTYAAIRLRQMNYSVVVIEKED 77
Cdd:PRK01747  234 MLVGELEQTLPAPLAAPWfARPGSPKA-------RDAAIIGGGIAGAALALALARRGWQVTLYEADE 293
PLN02268 PLN02268
probable polyamine oxidase
 47-98 8.09e-04

probable polyamine oxidase


Pssm-ID: 177909 [Multi-domain]  Cd Length: 435  Bit Score: 41.60  E-value: 8.09e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2027918103  47 VAIIGGGSAGTYAAIRLRQMNYSVVVIEKEDHLGGHVntYTEPTTGIAADYG 98
Cdd:PLN02268    3 VIVIGGGIAGIAAARALHDASFKVTLLESRDRIGGRV--HTDYSFGFPVDMG 52
PLN02172 PLN02172
flavin-containing monooxygenase FMO GS-OX
 37-81 9.75e-04

flavin-containing monooxygenase FMO GS-OX


Pssm-ID: 215116 [Multi-domain]  Cd Length: 461  Bit Score: 41.39  E-value: 9.75e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2027918103  37 PESQQSIIRDVAIIGGGSAGTYAAIRLRQMNYSVVVIEKEDHLGG 81
Cdd:PLN02172    3 PAQNPINSQHVAVIGAGAAGLVAARELRREGHTVVVFEREKQVGG 47
trkA PRK09496
Trk system potassium transporter TrkA;
44-75 1.40e-03

Trk system potassium transporter TrkA;


Pssm-ID: 236541 [Multi-domain]  Cd Length: 453  Bit Score: 40.88  E-value: 1.40e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 2027918103  44 IRDVAIIGGGSAGTYAAIRLRQMNYSVVVIEK 75
Cdd:PRK09496  231 VKRVMIVGGGNIGYYLAKLLEKEGYSVKLIER 262
PLN02328 PLN02328
lysine-specific histone demethylase 1 homolog
 46-98 2.10e-03

lysine-specific histone demethylase 1 homolog


Pssm-ID: 215187 [Multi-domain]  Cd Length: 808  Bit Score: 40.75  E-value: 2.10e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2027918103  46 DVAIIGGGSAGTYAAIRLRQMNYSVVVIEKEDHLGGHVNTYTEPTTGI--AADYG 98
Cdd:PLN02328  240 NVVVVGAGLAGLVAARQLLSMGFKVVVLEGRARPGGRVKTMKMKGDGVvaAADLG 294
PRK06854 PRK06854
adenylyl-sulfate reductase subunit alpha;
46-75 2.21e-03

adenylyl-sulfate reductase subunit alpha;


Pssm-ID: 235879 [Multi-domain]  Cd Length: 608  Bit Score: 40.68  E-value: 2.21e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 2027918103  46 DVAIIGGGSAGTYAAIRLRQM--NYSVVVIEK 75
Cdd:PRK06854   13 DILIIGGGMAGCGAAFEAKEWapDLKVLIVEK 44
PRK05249 PRK05249
Si-specific NAD(P)(+) transhydrogenase;
46-89 2.51e-03

Si-specific NAD(P)(+) transhydrogenase;


Pssm-ID: 235373 [Multi-domain]  Cd Length: 461  Bit Score: 40.14  E-value: 2.51e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2027918103  46 DVAIIGGGSAGTYAAIRLRQMNYSVVVIEKEDHLGGH-VNTYTEP 89
Cdd:PRK05249    7 DLVVIGSGPAGEGAAMQAAKLGKRVAVIERYRNVGGGcTHTGTIP 51
PRK11728 PRK11728
L-2-hydroxyglutarate oxidase;
44-82 2.64e-03

L-2-hydroxyglutarate oxidase;


Pssm-ID: 183292 [Multi-domain]  Cd Length: 393  Bit Score: 40.19  E-value: 2.64e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2027918103  44 IRDVAIIGGGSAGTYAAIRL--RQMNYSVVVIEKEDHLGGH 82
Cdd:PRK11728    2 MYDFVIIGGGIVGLSTAMQLqeRYPGARIAVLEKESGPARH 42
GIDA pfam01134
Glucose inhibited division protein A;
46-80 3.70e-03

Glucose inhibited division protein A;


Pssm-ID: 250388 [Multi-domain]  Cd Length: 391  Bit Score: 39.46  E-value: 3.70e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2027918103  46 DVAIIGGGSAGTYAAIRLRQMNYSVVVI-EKEDHLG 80
Cdd:pfam01134   1 DVIVIGGGHAGCEAALAAARMGAKVLLItHNTDTIA 36
NadB COG0029
Aspartate oxidase [Coenzyme transport and metabolism]; Aspartate oxidase is part of the ...
 46-86 4.22e-03

Aspartate oxidase [Coenzyme transport and metabolism]; Aspartate oxidase is part of the Pathway/BioSystem: NAD biosynthesis


Pssm-ID: 439800 [Multi-domain]  Cd Length: 521  Bit Score: 39.70  E-value: 4.22e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2027918103  46 DVAIIGGGSAGTYAAIRLRQmNYSVVVIEKEDHLGGhvNTY 86
Cdd:COG0029     6 DVLVIGSGIAGLSAALKLAE-RGRVTLLTKGELGES--NTR 43
TrkA COG0569
Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion ...
 47-75 7.21e-03

Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440335 [Multi-domain]  Cd Length: 296  Bit Score: 38.51  E-value: 7.21e-03
                          10        20
                  ....*....|....*....|....*....
gi 2027918103  47 VAIIGGGSAGTYAAIRLRQMNYSVVVIEK 75
Cdd:COG0569    98 VIIIGAGRVGRSLARELEEEGHDVVVIDK 126
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH