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Conserved domains on  [gi|2119468312|ref|XP_044539170|]
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sushi domain-containing protein 2-like [Gracilinanus agilis]

Protein Classification

VWD and CCP domain-containing protein( domain architecture ID 10243762)

VWD and CCP domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
VWD super family cl47498
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 136-302 2.04e-18

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


The actual alignment was detected with superfamily member pfam00094:

Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 82.03  E-value: 2.04e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119468312 136 SVFGDPHFLTFDGVRFTFNGRGEYILVQ--SDLTGLQVQARTRAAtsvsGGQASATGISAVVVKEGDSDVLearlgdaVG 213
Cdd:pfam00094   2 SVSGDPHYVTFDGVKYTFPGTCTYVLAKdcSEEPDFSFSVTNKNC----NGGASGVCLKSVTVIVGDLEIT-------LQ 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119468312 214 RPLEVLLNQKILTFSEQSwmdlKGMFLSMSGSQKATVMLASGAGLEIeaheAFLG---LSVILPDKFLARTRGLLGTLNG 290
Cdd:pfam00094  71 KGGTVLVNGQKVSLPYKS----DGGEVEILGSGFVVVDLSPGVGLQV----DGDGrgqLFVTLSPSYQGKTCGLCGNYNG 142

                         170
                  ....*....|..
gi 2119468312 291 VSADDFTLRNGS 302
Cdd:pfam00094 143 NQEDDFMTPDGT 154
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 411-465 4.16e-18

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


:

Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 77.89  E-value: 4.16e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2119468312 411 CGWLPPPEHGKKNG--TSYLVGSSIRFSCMPGFTLRGSKERTCQPDGKWSGSPPHCR 465
Cdd:cd00033     1 CPPPPVPENGTVTGskGSYSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTCE 57
 
Name Accession Description Interval E-value
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 136-302 2.04e-18

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 82.03  E-value: 2.04e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119468312 136 SVFGDPHFLTFDGVRFTFNGRGEYILVQ--SDLTGLQVQARTRAAtsvsGGQASATGISAVVVKEGDSDVLearlgdaVG 213
Cdd:pfam00094   2 SVSGDPHYVTFDGVKYTFPGTCTYVLAKdcSEEPDFSFSVTNKNC----NGGASGVCLKSVTVIVGDLEIT-------LQ 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119468312 214 RPLEVLLNQKILTFSEQSwmdlKGMFLSMSGSQKATVMLASGAGLEIeaheAFLG---LSVILPDKFLARTRGLLGTLNG 290
Cdd:pfam00094  71 KGGTVLVNGQKVSLPYKS----DGGEVEILGSGFVVVDLSPGVGLQV----DGDGrgqLFVTLSPSYQGKTCGLCGNYNG 142

                         170
                  ....*....|..
gi 2119468312 291 VSADDFTLRNGS 302
Cdd:pfam00094 143 NQEDDFMTPDGT 154
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 411-465 4.16e-18

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 77.89  E-value: 4.16e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2119468312 411 CGWLPPPEHGKKNG--TSYLVGSSIRFSCMPGFTLRGSKERTCQPDGKWSGSPPHCR 465
Cdd:cd00033     1 CPPPPVPENGTVTGskGSYSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTCE 57
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 135-301 1.11e-17

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 80.14  E-value: 1.11e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119468312  135 ASVFGDPHFLTFDGVRFTFNGRGEYILVQSDLTGLQ--VQARTRAAtsvsggQASATGISAVVVKEGDSDVLEARLGDav 212
Cdd:smart00216  12 CSVSGDPHYTTFDGVAYTFPGNCYYVLAQDCSSEPTfsVLLKNVPC------GGGATCLKSVKVELNGDEIELKDDNG-- 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119468312  213 grplEVLLNQKILTFSEQSwmdlKGMFLSMSGSQKATVMLASGAGLEIeaheAFLG---LSVILPDKFLARTRGLLGTLN 289
Cdd:smart00216  84 ----KVTVNGQQVSLPYKT----SDGSIQIRSSGGYLVVITSLGLIQV----TFDGltlLSVQLPSKYRGKTCGLCGNFD 151

                          170
                   ....*....|..
gi 2119468312  290 GVSADDFTLRNG 301
Cdd:smart00216 152 GEPEDDFRTPDG 163
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 411-464 1.00e-15

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 71.40  E-value: 1.00e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2119468312  411 CGWLPPPEHGKKNGTS--YLVGSSIRFSCMPGFTLRGSKERTCQPDGKWSGSPPHC 464
Cdd:smart00032   1 CPPPPDIENGTVTSSSgtYSYGDTVTYSCDPGYTLIGSSTITCLENGTWSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
411-464 3.74e-14

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 66.75  E-value: 3.74e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2119468312 411 CGWLPPPEHGKKNGT--SYLVGSSIRFSCMPGFTLRGSKERTCQPDGKWSGSPPHC 464
Cdd:pfam00084   1 CPPPPDIPNGKVSATknEYNYGASVSYECDPGYRLVGSPTITCQEDGTWSPPFPEC 56
PHA02954 PHA02954
EEV membrane glycoprotein; Provisional
 414-464 2.25e-04

EEV membrane glycoprotein; Provisional


Pssm-ID: 165263 [Multi-domain]  Cd Length: 317  Bit Score: 43.15  E-value: 2.25e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2119468312 414 LPPPEHGKKNGTSYLVGSSIRFSCMPGFTLRGSKERTCqPDGKWSGSPPHC 464
Cdd:PHA02954  188 IPSLSNGLISGSTFSIGGVIHLSCKSGFTLTGSPSSTC-IDGKWNPVLPIC 237
 
Name Accession Description Interval E-value
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 136-302 2.04e-18

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 82.03  E-value: 2.04e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119468312 136 SVFGDPHFLTFDGVRFTFNGRGEYILVQ--SDLTGLQVQARTRAAtsvsGGQASATGISAVVVKEGDSDVLearlgdaVG 213
Cdd:pfam00094   2 SVSGDPHYVTFDGVKYTFPGTCTYVLAKdcSEEPDFSFSVTNKNC----NGGASGVCLKSVTVIVGDLEIT-------LQ 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119468312 214 RPLEVLLNQKILTFSEQSwmdlKGMFLSMSGSQKATVMLASGAGLEIeaheAFLG---LSVILPDKFLARTRGLLGTLNG 290
Cdd:pfam00094  71 KGGTVLVNGQKVSLPYKS----DGGEVEILGSGFVVVDLSPGVGLQV----DGDGrgqLFVTLSPSYQGKTCGLCGNYNG 142

                         170
                  ....*....|..
gi 2119468312 291 VSADDFTLRNGS 302
Cdd:pfam00094 143 NQEDDFMTPDGT 154
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 411-465 4.16e-18

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 77.89  E-value: 4.16e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2119468312 411 CGWLPPPEHGKKNG--TSYLVGSSIRFSCMPGFTLRGSKERTCQPDGKWSGSPPHCR 465
Cdd:cd00033     1 CPPPPVPENGTVTGskGSYSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTCE 57
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 135-301 1.11e-17

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 80.14  E-value: 1.11e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119468312  135 ASVFGDPHFLTFDGVRFTFNGRGEYILVQSDLTGLQ--VQARTRAAtsvsggQASATGISAVVVKEGDSDVLEARLGDav 212
Cdd:smart00216  12 CSVSGDPHYTTFDGVAYTFPGNCYYVLAQDCSSEPTfsVLLKNVPC------GGGATCLKSVKVELNGDEIELKDDNG-- 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119468312  213 grplEVLLNQKILTFSEQSwmdlKGMFLSMSGSQKATVMLASGAGLEIeaheAFLG---LSVILPDKFLARTRGLLGTLN 289
Cdd:smart00216  84 ----KVTVNGQQVSLPYKT----SDGSIQIRSSGGYLVVITSLGLIQV----TFDGltlLSVQLPSKYRGKTCGLCGNFD 151

                          170
                   ....*....|..
gi 2119468312  290 GVSADDFTLRNG 301
Cdd:smart00216 152 GEPEDDFRTPDG 163
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 411-464 1.00e-15

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 71.40  E-value: 1.00e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2119468312  411 CGWLPPPEHGKKNGTS--YLVGSSIRFSCMPGFTLRGSKERTCQPDGKWSGSPPHC 464
Cdd:smart00032   1 CPPPPDIENGTVTSSSgtYSYGDTVTYSCDPGYTLIGSSTITCLENGTWSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
411-464 3.74e-14

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 66.75  E-value: 3.74e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2119468312 411 CGWLPPPEHGKKNGT--SYLVGSSIRFSCMPGFTLRGSKERTCQPDGKWSGSPPHC 464
Cdd:pfam00084   1 CPPPPDIPNGKVSATknEYNYGASVSYECDPGYRLVGSPTITCQEDGTWSPPFPEC 56
PHA02954 PHA02954
EEV membrane glycoprotein; Provisional
 414-464 2.25e-04

EEV membrane glycoprotein; Provisional


Pssm-ID: 165263 [Multi-domain]  Cd Length: 317  Bit Score: 43.15  E-value: 2.25e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2119468312 414 LPPPEHGKKNGTSYLVGSSIRFSCMPGFTLRGSKERTCqPDGKWSGSPPHC 464
Cdd:PHA02954  188 IPSLSNGLISGSTFSIGGVIHLSCKSGFTLTGSPSSTC-IDGKWNPVLPIC 237
PHA02817 PHA02817
EEV Host range protein; Provisional
 416-465 3.27e-03

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 39.15  E-value: 3.27e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2119468312 416 PPEhgKKNG------TSYLVGSSIRFSCMPG-----FTLRGSKERTCQPDGKWSGSPPHCR 465
Cdd:PHA02817   27 PPS--IKNGyiynkkTEYNIGSNVTFFCGNNtrgvrYTLVGEKNIICEKDGKWNKEFPVCK 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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