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treacle protein isoform X12 [Homo sapiens]
Protein Classification
WD40 repeat domain-containing protein ( domain architecture ID 12218018 )
WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly
List of domain hits
Name
Accession
Description
Interval
E-value
Treacle
pfam03546 Treacher Collins syndrome protein Treacle;
387-861
2.57e-63
Treacher Collins syndrome protein Treacle;
Pssm-ID: 460967 [Multi-domain]
Cd Length: 531
Bit Score: 225.72
E-value: 2.57e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357116 387 A PA P PGK T GPA VAK A Q AGK R EEDS Q SSSEE S ------ DSEEEA P A QAKPSGK A PQVRAASAPAKESPRKGA A P A PP R KTG 460
Cdd:pfam03546 1 T PA T PGK A GPA ATQ A K AGK P EEDS E SSSEE E sdseee TPAAKT P L QAKPSGK T PQVRAASAPAKESPRKGA P P V PP G KTG 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357116 461 PAAAQ V Q V GK Q EEDS R SSSEESDSD R E AL AA M ---- NA AQVKPLGK SP QV K PAST M G M GP L GKGA G P V PPGK V G P A T P SA 536
Cdd:pfam03546 81 PAAAQ A Q A GK P EEDS E SSSEESDSD G E TP AA A tltt SP AQVKPLGK NS QV R PAST V G K GP S GKGA N P A PPGK A G S A A P LV 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357116 537 QVGK weed S E SS SE E SS DS SD G E VPTAV A PA Q E K SL G N ILQ AK P T S S PAKG ---- PPQKAGPVA V QVKAE KPMDN SESSE 612
Cdd:pfam03546 161 QVGK ---- K E ED SE S SS EE SD S E GEAPP A AT Q A K PS G K ILQ VR P A S G PAKG aapa PPQKAGPVA T QVKAE RSKED SESSE 236
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357116 613 ESSDS ADSEE A P A AMTA A qa KPALK I PQTKA C P K K TN -- T TA SAKV A PVRVGT Q AP R KAGT A TSPA G - SSPAVA G G T QRP 689
Cdd:pfam03546 237 ESSDS EEEAP A A A TPAQ A -- KPALK T PQTKA S P R K GT pi T PT SAKV P PVRVGT P AP W KAGT V TSPA C a SSPAVA R G A QRP 314
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357116 690 a E DS SSS E E SDSE EE K T GL A VT VGQAKSVGKGLQ V KAAS V P V KG SL GQGTAPV L PGKTGP T V T QVKAE K QEDSESSEEES 769
Cdd:pfam03546 315 - E ED SSS S E ESES EE E T AP A AA VGQAKSVGKGLQ G KAAS A P T KG PS GQGTAPV P PGKTGP A V A QVKAE A QEDSESSEEES 393
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357116 770 DSEEAAA S PAQVK T S V K KT QAKANPA AAR A P SAKG TI SAPGKVV T AAAQAKQ R SP S KVKP SGK T H Q IR A ALAPAKE S PR - 848
Cdd:pfam03546 394 DSEEAAA T PAQVK A S G K TP QAKANPA PTK A S SAKG AA SAPGKVV A AAAQAKQ G SP A KVKP PAR T P Q NS A ISVRGQA S VP a 473
490
....*....|....*
gi 2217357116 849 -- K GA A PTPPGKT GP 861
Cdd:pfam03546 474 vg K AV A TAAQAQK GP 488
Treacle super family
cl25490 Treacher Collins syndrome protein Treacle;
212-511
2.35e-09
Treacher Collins syndrome protein Treacle;
pfam03546 :Pssm-ID: 460967 [Multi-domain]
Cd Length: 531
Bit Score: 61.63
E-value: 2.35e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357116 212 VEG KP SV K PA Q V KAS S -------- V S T K ES P A R KAA PAP G K V G D VT PQVKGGALPP A KR A KK PEE E S E SSEE GSES EE E A 283
Cdd:pfam03546 252 AQA KP AL K TP Q T KAS P rkgtpitp T S A K VP P V R VGT PAP W K A G T VT SPACASSPAV A RG A QR PEE D S S SSEE SESE EE T A 331
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357116 284 PA GTRS Q V K ASE K I LQ VR AASAP A KG TP G K G AT P A PPGK A G AVAS Q T KA GKP E EDSE S SS E ES S DSEEE TP aakal L Q A K 363
Cdd:pfam03546 332 PA AAVG Q A K SVG K G LQ GK AASAP T KG PS G Q G TA P V PPGK T G PAVA Q V KA EAQ E DSES S EE E SD S EEAAA TP ----- A Q V K 406
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357116 364 ASGKT S Q VG A AS AP A K E S PR KGAA P A p PGK TGP A V A K A QA G kreedsqssseesdseee A PA QA KP SGKA PQ VR A A S A pa 443
Cdd:pfam03546 407 ASGKT P Q AK A NP AP T K A S SA KGAA S A - PGK VVA A A A Q A KQ G ------------------ S PA KV KP PART PQ NS A I S V -- 465
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2217357116 444 kesp R KG A APAPPR K TGPA AAQ V Q V G KQEEDSRSS SE E S DSDREALAAM n A AQ V KP L GK S PQV KP AS T 511
Cdd:pfam03546 466 ---- R GQ A SVPAVG K AVAT AAQ A Q K G PVGGPQEED SE S S EEESDSEEEA - P AQ A KP S GK T PQV RA AS A 528
LisH
smart00667 Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ...
6-37
2.81e-03
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.
Pssm-ID: 128913
Cd Length: 34
Bit Score: 36.64
E-value: 2.81e-03
10 20 30
....*....|....*....|....*....|..
gi 2217357116 6 K R R EL LP LI YHH LLR A GY VRA A REVKEQ SG QK 37
Cdd:smart00667 2 S R S EL NR LI LEY LLR N GY EET A ETLQKE SG LS 33
Name
Accession
Description
Interval
E-value
Treacle
pfam03546 Treacher Collins syndrome protein Treacle;
387-861
2.57e-63
Treacher Collins syndrome protein Treacle;
Pssm-ID: 460967 [Multi-domain]
Cd Length: 531
Bit Score: 225.72
E-value: 2.57e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357116 387 A PA P PGK T GPA VAK A Q AGK R EEDS Q SSSEE S ------ DSEEEA P A QAKPSGK A PQVRAASAPAKESPRKGA A P A PP R KTG 460
Cdd:pfam03546 1 T PA T PGK A GPA ATQ A K AGK P EEDS E SSSEE E sdseee TPAAKT P L QAKPSGK T PQVRAASAPAKESPRKGA P P V PP G KTG 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357116 461 PAAAQ V Q V GK Q EEDS R SSSEESDSD R E AL AA M ---- NA AQVKPLGK SP QV K PAST M G M GP L GKGA G P V PPGK V G P A T P SA 536
Cdd:pfam03546 81 PAAAQ A Q A GK P EEDS E SSSEESDSD G E TP AA A tltt SP AQVKPLGK NS QV R PAST V G K GP S GKGA N P A PPGK A G S A A P LV 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357116 537 QVGK weed S E SS SE E SS DS SD G E VPTAV A PA Q E K SL G N ILQ AK P T S S PAKG ---- PPQKAGPVA V QVKAE KPMDN SESSE 612
Cdd:pfam03546 161 QVGK ---- K E ED SE S SS EE SD S E GEAPP A AT Q A K PS G K ILQ VR P A S G PAKG aapa PPQKAGPVA T QVKAE RSKED SESSE 236
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357116 613 ESSDS ADSEE A P A AMTA A qa KPALK I PQTKA C P K K TN -- T TA SAKV A PVRVGT Q AP R KAGT A TSPA G - SSPAVA G G T QRP 689
Cdd:pfam03546 237 ESSDS EEEAP A A A TPAQ A -- KPALK T PQTKA S P R K GT pi T PT SAKV P PVRVGT P AP W KAGT V TSPA C a SSPAVA R G A QRP 314
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357116 690 a E DS SSS E E SDSE EE K T GL A VT VGQAKSVGKGLQ V KAAS V P V KG SL GQGTAPV L PGKTGP T V T QVKAE K QEDSESSEEES 769
Cdd:pfam03546 315 - E ED SSS S E ESES EE E T AP A AA VGQAKSVGKGLQ G KAAS A P T KG PS GQGTAPV P PGKTGP A V A QVKAE A QEDSESSEEES 393
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357116 770 DSEEAAA S PAQVK T S V K KT QAKANPA AAR A P SAKG TI SAPGKVV T AAAQAKQ R SP S KVKP SGK T H Q IR A ALAPAKE S PR - 848
Cdd:pfam03546 394 DSEEAAA T PAQVK A S G K TP QAKANPA PTK A S SAKG AA SAPGKVV A AAAQAKQ G SP A KVKP PAR T P Q NS A ISVRGQA S VP a 473
490
....*....|....*
gi 2217357116 849 -- K GA A PTPPGKT GP 861
Cdd:pfam03546 474 vg K AV A TAAQAQK GP 488
Treacle
pfam03546 Treacher Collins syndrome protein Treacle;
212-511
2.35e-09
Treacher Collins syndrome protein Treacle;
Pssm-ID: 460967 [Multi-domain]
Cd Length: 531
Bit Score: 61.63
E-value: 2.35e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357116 212 VEG KP SV K PA Q V KAS S -------- V S T K ES P A R KAA PAP G K V G D VT PQVKGGALPP A KR A KK PEE E S E SSEE GSES EE E A 283
Cdd:pfam03546 252 AQA KP AL K TP Q T KAS P rkgtpitp T S A K VP P V R VGT PAP W K A G T VT SPACASSPAV A RG A QR PEE D S S SSEE SESE EE T A 331
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357116 284 PA GTRS Q V K ASE K I LQ VR AASAP A KG TP G K G AT P A PPGK A G AVAS Q T KA GKP E EDSE S SS E ES S DSEEE TP aakal L Q A K 363
Cdd:pfam03546 332 PA AAVG Q A K SVG K G LQ GK AASAP T KG PS G Q G TA P V PPGK T G PAVA Q V KA EAQ E DSES S EE E SD S EEAAA TP ----- A Q V K 406
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357116 364 ASGKT S Q VG A AS AP A K E S PR KGAA P A p PGK TGP A V A K A QA G kreedsqssseesdseee A PA QA KP SGKA PQ VR A A S A pa 443
Cdd:pfam03546 407 ASGKT P Q AK A NP AP T K A S SA KGAA S A - PGK VVA A A A Q A KQ G ------------------ S PA KV KP PART PQ NS A I S V -- 465
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2217357116 444 kesp R KG A APAPPR K TGPA AAQ V Q V G KQEEDSRSS SE E S DSDREALAAM n A AQ V KP L GK S PQV KP AS T 511
Cdd:pfam03546 466 ---- R GQ A SVPAVG K AVAT AAQ A Q K G PVGGPQEED SE S S EEESDSEEEA - P AQ A KP S GK T PQV RA AS A 528
PHA03247
PHA03247 large tegument protein UL36; Provisional
157-535
6.05e-06
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain]
Cd Length: 3151
Bit Score: 51.48
E-value: 6.05e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357116 157 P RK S AE P S AN TTLVSETEEEGSVPAFGAAAK PG M VS AGQADSSSEDTSSS S DETDVEGKPSVK P AQVKAS S VSTKES P AR 236
Cdd:PHA03247 2627 P PP S PS P A AN EPDPHPPPTVPPPERPRDDPA PG R VS RPRRARRLGRAAQA S SPPQRPRRRAAR P TVGSLT S LADPPP P PP 2706
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357116 237 KAA PAP gkvgdv TPQ V KGGA LPP AKR A KKPEEESESSEEGSESEEEA PA GTRSQVKASEKILQVRAASAPAKGT P GK G AT 316
Cdd:PHA03247 2707 TPE PAP ------ HAL V SATP LPP GPA A ARQASPALPAAPAPPAVPAG PA TPGGPARPARPPTTAGPPAPAPPAA P AA G PP 2780
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357116 317 PAPPGK A G A VA S QTKAGK P EEDSESSSEESSDSEEETPAAK A LLQAKASGK TS QVGA A SA P AKE sprkga A P A P PGKT G P 396
Cdd:PHA03247 2781 RRLTRP A V A SL S ESRESL P SPWDPADPPAAVLAPAAALPPA A SPAGPLPPP TS AQPT A PP P PPG ------ P P P P SLPL G G 2854
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357116 397 A VA KAQAGK R EED S Q S SSEESDSEEEA P AQ --- AKPSGKAPQVR A ASAPAK E S P RKGA AP A PP RKTGPAAAQV Q vgkqe E 473
Cdd:PHA03247 2855 S VA PGGDVR R RPP S R S PAAKPAAPARP P VR rla RPAVSRSTESF A LPPDQP E R P PQPQ AP P PP QPQPQPPPPP Q ----- P 2929
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2217357116 474 DSRSSSEESDSDRE A LAAMN A AQVK P L G KS PQ VK pastmg M G P L GK G AGP VP PGK V GPAT PS 535
Cdd:PHA03247 2930 QPPPPPPPRPQPPL A PTTDP A GAGE P S G AV PQ PW ------ L G A L VP G RVA VP RFR V PQPA PS 2985
PHA03247
PHA03247 large tegument protein UL36; Provisional
234-676
1.06e-05
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain]
Cd Length: 3151
Bit Score: 50.32
E-value: 1.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357116 234 P ARKA AP A P GKVGDVTPQVKGG A L P PAK R AKK P EEESESSEEGSESEEEA P AGTRSQVKASE kilqv RAAS A PAKGTPGK 313
Cdd:PHA03247 2569 P PPRP AP R P SEPAVTSRARRPD A P P QSA R PRA P VDDRGDPRGPAPPSPLP P DTHAPDPPPPS ----- PSPA A NEPDPHPP 2643
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357116 314 GAT P A P PGKAGA v ASQTKAGK P EEDSESSSEESSD S EEET P AAK A LLQAKA S GKTSQVGAASA P AK E SPRKGAAP A P P GK 393
Cdd:PHA03247 2644 PTV P P P ERPRDD - PAPGRVSR P RRARRLGRAAQAS S PPQR P RRR A ARPTVG S LTSLADPPPPP P TP E PAPHALVS A T P LP 2722
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357116 394 T GPA V A KAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRA A S AP akes P RKG AA PA P P R K T G PA A A QVQVGKQEE 473
Cdd:PHA03247 2723 P GPA A A RQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPP A P AP ---- P AAP AA GP P R R L T R PA V A SLSESRESL 2798
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357116 474 D S RSSSEESDSDRE A L AA MNAAQVK P L G KS P qvk P ASTMGMGPLGKGA GP V PP ----- G K V G P ATPSAQVGKWEEDSESS 548
Cdd:PHA03247 2799 P S PWDPADPPAAVL A P AA ALPPAAS P A G PL P --- P PTSAQPTAPPPPP GP P PP slplg G S V A P GGDVRRRPPSRSPAAKP 2875
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357116 549 SEESSDSSDGEVPT AV APAQ E K - S L GNILQAK P TSSP A KG PPQ KAGPVAVQVKAEK P MDNSESSEESSDSADSEEAPAAM 627
Cdd:PHA03247 2876 AAPARPPVRRLARP AV SRST E S f A L PPDQPER P PQPQ A PP PPQ PQPQPPPPPQPQP P PPPPPRPQPPLAPTTDPAGAGEP 2955
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 2217357116 628 TA A QAK P A L -------- KI P QTKACPKKTNTT A S A KVA P VRV G TQAP R KAGT A T S P A 676
Cdd:PHA03247 2956 SG A VPQ P W L galvpgrv AV P RFRVPQPAPSRE A P A SST P PLT G HSLS R VSSW A S S L A 3012
LisH
smart00667 Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ...
6-37
2.81e-03
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.
Pssm-ID: 128913
Cd Length: 34
Bit Score: 36.64
E-value: 2.81e-03
10 20 30
....*....|....*....|....*....|..
gi 2217357116 6 K R R EL LP LI YHH LLR A GY VRA A REVKEQ SG QK 37
Cdd:smart00667 2 S R S EL NR LI LEY LLR N GY EET A ETLQKE SG LS 33
Name
Accession
Description
Interval
E-value
Treacle
pfam03546 Treacher Collins syndrome protein Treacle;
387-861
2.57e-63
Treacher Collins syndrome protein Treacle;
Pssm-ID: 460967 [Multi-domain]
Cd Length: 531
Bit Score: 225.72
E-value: 2.57e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357116 387 A PA P PGK T GPA VAK A Q AGK R EEDS Q SSSEE S ------ DSEEEA P A QAKPSGK A PQVRAASAPAKESPRKGA A P A PP R KTG 460
Cdd:pfam03546 1 T PA T PGK A GPA ATQ A K AGK P EEDS E SSSEE E sdseee TPAAKT P L QAKPSGK T PQVRAASAPAKESPRKGA P P V PP G KTG 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357116 461 PAAAQ V Q V GK Q EEDS R SSSEESDSD R E AL AA M ---- NA AQVKPLGK SP QV K PAST M G M GP L GKGA G P V PPGK V G P A T P SA 536
Cdd:pfam03546 81 PAAAQ A Q A GK P EEDS E SSSEESDSD G E TP AA A tltt SP AQVKPLGK NS QV R PAST V G K GP S GKGA N P A PPGK A G S A A P LV 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357116 537 QVGK weed S E SS SE E SS DS SD G E VPTAV A PA Q E K SL G N ILQ AK P T S S PAKG ---- PPQKAGPVA V QVKAE KPMDN SESSE 612
Cdd:pfam03546 161 QVGK ---- K E ED SE S SS EE SD S E GEAPP A AT Q A K PS G K ILQ VR P A S G PAKG aapa PPQKAGPVA T QVKAE RSKED SESSE 236
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357116 613 ESSDS ADSEE A P A AMTA A qa KPALK I PQTKA C P K K TN -- T TA SAKV A PVRVGT Q AP R KAGT A TSPA G - SSPAVA G G T QRP 689
Cdd:pfam03546 237 ESSDS EEEAP A A A TPAQ A -- KPALK T PQTKA S P R K GT pi T PT SAKV P PVRVGT P AP W KAGT V TSPA C a SSPAVA R G A QRP 314
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357116 690 a E DS SSS E E SDSE EE K T GL A VT VGQAKSVGKGLQ V KAAS V P V KG SL GQGTAPV L PGKTGP T V T QVKAE K QEDSESSEEES 769
Cdd:pfam03546 315 - E ED SSS S E ESES EE E T AP A AA VGQAKSVGKGLQ G KAAS A P T KG PS GQGTAPV P PGKTGP A V A QVKAE A QEDSESSEEES 393
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357116 770 DSEEAAA S PAQVK T S V K KT QAKANPA AAR A P SAKG TI SAPGKVV T AAAQAKQ R SP S KVKP SGK T H Q IR A ALAPAKE S PR - 848
Cdd:pfam03546 394 DSEEAAA T PAQVK A S G K TP QAKANPA PTK A S SAKG AA SAPGKVV A AAAQAKQ G SP A KVKP PAR T P Q NS A ISVRGQA S VP a 473
490
....*....|....*
gi 2217357116 849 -- K GA A PTPPGKT GP 861
Cdd:pfam03546 474 vg K AV A TAAQAQK GP 488
Treacle
pfam03546 Treacher Collins syndrome protein Treacle;
212-511
2.35e-09
Treacher Collins syndrome protein Treacle;
Pssm-ID: 460967 [Multi-domain]
Cd Length: 531
Bit Score: 61.63
E-value: 2.35e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357116 212 VEG KP SV K PA Q V KAS S -------- V S T K ES P A R KAA PAP G K V G D VT PQVKGGALPP A KR A KK PEE E S E SSEE GSES EE E A 283
Cdd:pfam03546 252 AQA KP AL K TP Q T KAS P rkgtpitp T S A K VP P V R VGT PAP W K A G T VT SPACASSPAV A RG A QR PEE D S S SSEE SESE EE T A 331
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357116 284 PA GTRS Q V K ASE K I LQ VR AASAP A KG TP G K G AT P A PPGK A G AVAS Q T KA GKP E EDSE S SS E ES S DSEEE TP aakal L Q A K 363
Cdd:pfam03546 332 PA AAVG Q A K SVG K G LQ GK AASAP T KG PS G Q G TA P V PPGK T G PAVA Q V KA EAQ E DSES S EE E SD S EEAAA TP ----- A Q V K 406
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357116 364 ASGKT S Q VG A AS AP A K E S PR KGAA P A p PGK TGP A V A K A QA G kreedsqssseesdseee A PA QA KP SGKA PQ VR A A S A pa 443
Cdd:pfam03546 407 ASGKT P Q AK A NP AP T K A S SA KGAA S A - PGK VVA A A A Q A KQ G ------------------ S PA KV KP PART PQ NS A I S V -- 465
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2217357116 444 kesp R KG A APAPPR K TGPA AAQ V Q V G KQEEDSRSS SE E S DSDREALAAM n A AQ V KP L GK S PQV KP AS T 511
Cdd:pfam03546 466 ---- R GQ A SVPAVG K AVAT AAQ A Q K G PVGGPQEED SE S S EEESDSEEEA - P AQ A KP S GK T PQV RA AS A 528
PHA03247
PHA03247 large tegument protein UL36; Provisional
157-535
6.05e-06
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain]
Cd Length: 3151
Bit Score: 51.48
E-value: 6.05e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357116 157 P RK S AE P S AN TTLVSETEEEGSVPAFGAAAK PG M VS AGQADSSSEDTSSS S DETDVEGKPSVK P AQVKAS S VSTKES P AR 236
Cdd:PHA03247 2627 P PP S PS P A AN EPDPHPPPTVPPPERPRDDPA PG R VS RPRRARRLGRAAQA S SPPQRPRRRAAR P TVGSLT S LADPPP P PP 2706
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357116 237 KAA PAP gkvgdv TPQ V KGGA LPP AKR A KKPEEESESSEEGSESEEEA PA GTRSQVKASEKILQVRAASAPAKGT P GK G AT 316
Cdd:PHA03247 2707 TPE PAP ------ HAL V SATP LPP GPA A ARQASPALPAAPAPPAVPAG PA TPGGPARPARPPTTAGPPAPAPPAA P AA G PP 2780
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357116 317 PAPPGK A G A VA S QTKAGK P EEDSESSSEESSDSEEETPAAK A LLQAKASGK TS QVGA A SA P AKE sprkga A P A P PGKT G P 396
Cdd:PHA03247 2781 RRLTRP A V A SL S ESRESL P SPWDPADPPAAVLAPAAALPPA A SPAGPLPPP TS AQPT A PP P PPG ------ P P P P SLPL G G 2854
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357116 397 A VA KAQAGK R EED S Q S SSEESDSEEEA P AQ --- AKPSGKAPQVR A ASAPAK E S P RKGA AP A PP RKTGPAAAQV Q vgkqe E 473
Cdd:PHA03247 2855 S VA PGGDVR R RPP S R S PAAKPAAPARP P VR rla RPAVSRSTESF A LPPDQP E R P PQPQ AP P PP QPQPQPPPPP Q ----- P 2929
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2217357116 474 DSRSSSEESDSDRE A LAAMN A AQVK P L G KS PQ VK pastmg M G P L GK G AGP VP PGK V GPAT PS 535
Cdd:PHA03247 2930 QPPPPPPPRPQPPL A PTTDP A GAGE P S G AV PQ PW ------ L G A L VP G RVA VP RFR V PQPA PS 2985
PHA03247
PHA03247 large tegument protein UL36; Provisional
234-676
1.06e-05
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain]
Cd Length: 3151
Bit Score: 50.32
E-value: 1.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357116 234 P ARKA AP A P GKVGDVTPQVKGG A L P PAK R AKK P EEESESSEEGSESEEEA P AGTRSQVKASE kilqv RAAS A PAKGTPGK 313
Cdd:PHA03247 2569 P PPRP AP R P SEPAVTSRARRPD A P P QSA R PRA P VDDRGDPRGPAPPSPLP P DTHAPDPPPPS ----- PSPA A NEPDPHPP 2643
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357116 314 GAT P A P PGKAGA v ASQTKAGK P EEDSESSSEESSD S EEET P AAK A LLQAKA S GKTSQVGAASA P AK E SPRKGAAP A P P GK 393
Cdd:PHA03247 2644 PTV P P P ERPRDD - PAPGRVSR P RRARRLGRAAQAS S PPQR P RRR A ARPTVG S LTSLADPPPPP P TP E PAPHALVS A T P LP 2722
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357116 394 T GPA V A KAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRA A S AP akes P RKG AA PA P P R K T G PA A A QVQVGKQEE 473
Cdd:PHA03247 2723 P GPA A A RQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPP A P AP ---- P AAP AA GP P R R L T R PA V A SLSESRESL 2798
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357116 474 D S RSSSEESDSDRE A L AA MNAAQVK P L G KS P qvk P ASTMGMGPLGKGA GP V PP ----- G K V G P ATPSAQVGKWEEDSESS 548
Cdd:PHA03247 2799 P S PWDPADPPAAVL A P AA ALPPAAS P A G PL P --- P PTSAQPTAPPPPP GP P PP slplg G S V A P GGDVRRRPPSRSPAAKP 2875
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357116 549 SEESSDSSDGEVPT AV APAQ E K - S L GNILQAK P TSSP A KG PPQ KAGPVAVQVKAEK P MDNSESSEESSDSADSEEAPAAM 627
Cdd:PHA03247 2876 AAPARPPVRRLARP AV SRST E S f A L PPDQPER P PQPQ A PP PPQ PQPQPPPPPQPQP P PPPPPRPQPPLAPTTDPAGAGEP 2955
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 2217357116 628 TA A QAK P A L -------- KI P QTKACPKKTNTT A S A KVA P VRV G TQAP R KAGT A T S P A 676
Cdd:PHA03247 2956 SG A VPQ P W L galvpgrv AV P RFRVPQPAPSRE A P A SST P PLT G HSLS R VSSW A S S L A 3012
PRK07003
PRK07003 DNA polymerase III subunit gamma/tau;
234-499
1.82e-04
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain]
Cd Length: 830
Bit Score: 46.00
E-value: 1.82e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357116 234 PA RKAAP APG kv G D V TPQ V K G GALP P AK RA kkpeeesesse EGSESEEEA PA G T RSQVK A SEKILQVR AA S A P A KGTPGK 313
Cdd:PRK07003 360 PA VTGGG APG -- G G V PAR V A G AVPA P GA RA ----------- AAAVGASAV PA V T AVTGA A GAALAPKA AA A A A A TRAEAP 426
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357116 314 G A T PAPP GK A GAVASQTKAGK P EEDSESSSEESSDSEE E TP A AKALLQAK AS GKT S QVGAAS A PAKESPRKGAAP A P P GK 393
Cdd:PRK07003 427 P A A PAPP AT A DRGDDAADGDA P VPAKANARASADSRCD E RD A QPPADSGS AS APA S DAPPDA A FEPAPRAAAPSA A T P AA 506
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357116 394 TGP A V A K A Q A GKREEDSQSSSEESDSEEEA PA Q A K P SGK A PQVR AA --------------- S A P A KESPRKG AAPA PPR K 458
Cdd:PRK07003 507 VPD A R A P A A A SREDAPAAAAPPAPEARPPT PA A A A P AAR A GGAA AA ldvlrnagmrvssdr G A R A AAAAKPA AAPA AAP K 586
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 2217357116 459 TGPAAAQ VQV GKQEEDSRSSSEESDSDRE A LA A MNAAQVK P 499
Cdd:PRK07003 587 PAAPRVA VQV PTPRARAATGDAPPNGAAR A EQ A AESRGAP P 627
kgd
PRK12270 multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
385-467
7.46e-04
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;
Pssm-ID: 237030 [Multi-domain]
Cd Length: 1228
Bit Score: 44.11
E-value: 7.46e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357116 385 G AAPAPPGKTGP A V A K A Q A GKREEDSQSSSEESDSEEEAP A Q A KPSGKA P QVR AA S A P A KES P RKG AA P A P P RKT ----- 459
Cdd:PRK12270 37 G PGSTAAPTAAA A A A A A A A SAPAAAPAAKAPAAPAPAPPA A A A PAAPPK P AAA AA A A A A PAA P PAA AA A A A P AAA avede 116
90
....*....|...
gi 2217357116 460 ----- G P AAA QVQ 467
Cdd:PRK12270 117 vtplr G A AAA VAK 129
PRK07003
PRK07003 DNA polymerase III subunit gamma/tau;
214-463
1.04e-03
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain]
Cd Length: 830
Bit Score: 43.68
E-value: 1.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357116 214 G K P SVKPAQ V K A SSVSTKESPARK A A PA PGK V GDVT pqvk G G AL P P AKR A KKPEEES E SSEEGSESEEE A PA G TRSQVKA 293
Cdd:PRK07003 371 G V P ARVAGA V P A PGARAAAAVGAS A V PA VTA V TGAA ---- G A AL A P KAA A AAAATRA E APPAAPAPPAT A DR G DDAADGD 446
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357116 294 SE ki LQVR A ASAPAKGTPGKGATPA PP GKA G AVASQTKAGK P EEDS E SSSEESSD S EEETP A AKALLQAK A SGKTSQVG A 373
Cdd:PRK07003 447 AP -- VPAK A NARASADSRCDERDAQ PP ADS G SASAPASDAP P DAAF E PAPRAAAP S AATPA A VPDARAPA A ASREDAPA A 524
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357116 374 A SA PA K E S - P RKG AA P AP PGKT G P A V A K ---- AQ AG K R EEDSQSSSEESDSEEE A PAQ A K P SGK AP Q V RA ------ A S A P 442
Cdd:PRK07003 525 A AP PA P E A r P PTP AA A AP AARA G G A A A A ldvl RN AG M R VSSDRGARAAAAAKPA A APA A A P KPA AP R V AV qvptpr A R A A 604
250 260
....*....|....*....|.
gi 2217357116 443 AKES P RK GAA P A PPRKTGPA A 463
Cdd:PRK07003 605 TGDA P PN GAA R A EQAAESRG A 625
PRK07764
PRK07764 DNA polymerase III subunits gamma and tau; Validated
177-465
2.54e-03
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain]
Cd Length: 824
Bit Score: 42.28
E-value: 2.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357116 177 GSV PA FG A AAKPGMVS A GQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSV S TKESPARKA AP A P GKVGDVTP Q VKGGA 256
Cdd:PRK07764 391 AGA PA AA A PSAAAAAP A AAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPP S PAGNAPAGG AP S P PPAAAPSA Q PAPAP 470
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357116 257 LPPAKRAKK P EEESESSEEGSESEEEAP A GTRSQ ------------------- V K A S E K ILQVRAAS A PAK G -------- 309
Cdd:PRK07764 471 AAAPEPTAA P APAPPAAPAPAAAPAAPA A PAAPA gaddaatlrerwpeilaav P K R S R K TWAILLPE A TVL G vrgdtlvl 550
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357116 310 --- T P G KGATP A P PG K A G ----------------- AV ASQTKAGKPE E DSESSSEESSDS E EET PAA K A LLQ A K A SGKTS 369
Cdd:PRK07764 551 gfs T G G LARRF A S PG N A E vlvtalaeelggdwqve AV VGPAPGAAGG E GPPAPASSGPPE E AAR PAA P A APA A P A APAPA 630
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357116 370 QVG AA S A P A KES P RK G A A PAPPGKTGP AV AK A QA G KREEDSQSSSEESDSEEE APA Q A K P SGK A PQVR A AS APA KESPRK 449
Cdd:PRK07764 631 GAA AA P A E A SAA P AP G V A APEHHPKHV AV PD A SD G GDGWPAKAGGAAPAAPPP APA P A A P AAP A GAAP A QP APA PAATPP 710
330
....*....|....*.
gi 2217357116 450 GAAPAP P RKTG P A AAQ 465
Cdd:PRK07764 711 AGQADD P AAQP P Q AAQ 726
LisH
smart00667 Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ...
6-37
2.81e-03
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.
Pssm-ID: 128913
Cd Length: 34
Bit Score: 36.64
E-value: 2.81e-03
10 20 30
....*....|....*....|....*....|..
gi 2217357116 6 K R R EL LP LI YHH LLR A GY VRA A REVKEQ SG QK 37
Cdd:smart00667 2 S R S EL NR LI LEY LLR N GY EET A ETLQKE SG LS 33
PRK12323
PRK12323 DNA polymerase III subunit gamma/tau;
309-541
3.10e-03
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain]
Cd Length: 700
Bit Score: 42.17
E-value: 3.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357116 309 G TP G K GA T PA PP g K A GA VA SQTK A GKPEEDSESSSEESSDSEEET PAA K A LLQ A K A SGKTSQVG A AS A P A KESPRKGAA P 388
Cdd:PRK12323 366 G QS G G GA G PA TA - A A AP VA QPAP A AAAPAAAAPAPAAPPAAPAAA PAA A A AAR A V A AAPARRSP A PE A L A AARQASARG P 444
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357116 389 APPGKTG PA V A K A Q A GKREEDSQSSSEESDSEEE APA Q A K P SGKAPQVRAASA P AK E S P RKG A A PAP PR ktg P A AA QVQV 468
Cdd:PRK12323 445 GGAPAPA PA P A A A P A AAARPAAAGPRPVAAAAAA APA R A A P AAAPAPADDDPP P WE E L P PEF A S PAP AQ --- P D AA PAGW 521
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217357116 469 GKQEEDSRSSSEES D SDREALA A MN AA QVKPLGKSPQVKP A stmgmgplgkgag P V PP GKVGPAT P SAQV G K W 541
Cdd:PRK12323 522 VAESIPDPATADPD D AFETLAP A PA AA PAPRAAAATEPVV A ------------- P R PP RASASGL P DMFD G D W 581
kgd
PRK12270 multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
378-465
5.66e-03
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;
Pssm-ID: 237030 [Multi-domain]
Cd Length: 1228
Bit Score: 41.41
E-value: 5.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357116 378 A KES P RKG AAP APPGKTGP A V A K A Q A gkreedsqssseesd SEEE A P A Q A K P SGKA P QVR A AS AP A K ESPRKG AA P AP PR 457
Cdd:PRK12270 34 A DYG P GST AAP TAAAAAAA A A A S A P A --------------- AAPA A K A P A A P APAP P AAA A PA AP P K PAAAAA AA A AP AA 98
....*...
gi 2217357116 458 KTGP AAA Q 465
Cdd:PRK12270 99 PPAA AAA A 106
PRK12323
PRK12323 DNA polymerase III subunit gamma/tau;
250-466
8.44e-03
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain]
Cd Length: 700
Bit Score: 40.63
E-value: 8.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357116 250 P QVK GG ALP PA KR A KK P EEESESSEEGSESEEE APA GTRSQVK A SE kilqvr AA S A P A KGTPGKG A TPA P PGK A G A V A S Q 329
Cdd:PRK12323 365 P GQS GG GAG PA TA A AA P VAQPAPAAAAPAAAAP APA APPAAPA A AP ------ AA A A A A RAVAAAP A RRS P APE A L A A A R Q 438
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357116 330 TK A GK P EEDSESSSEESSDSEEETPA A K A LLQAK asgktsqvg AA S A P A KESPRKG AA PAP P GKTG P AVAKAQAGKREED 409
Cdd:PRK12323 439 AS A RG P GGAPAPAPAPAAAPAAAARP A A A GPRPV --------- AA A A A A APARAAP AA APA P ADDD P PPWEELPPEFASP 509
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 2217357116 410 SQSSSEESDSEEE A PAQAK P SGKA P qv RA A SAPAKES P RKGA AP APPRK T G P AA A QV 466
Cdd:PRK12323 510 APAQPDAAPAGWV A ESIPD P ATAD P -- DD A FETLAPA P AAAP AP RAAAA T E P VV A PR 564
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
