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Conserved domains on  [gi|2217366267|ref|XP_047276048|]
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transportin-3 isoform X1 [Homo sapiens]

Protein Classification

exportin family protein( domain architecture ID 10551960)

exportin family protein such as exportin-T, which mediates the nuclear export of aminoacylated tRNAs or transportin-3 (importin), which transports target proteins into the nucleus

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Xpo1 pfam08389
Exportin 1-like protein; The sequences featured in this family are similar to a region close ...
 55-183 1.66e-20

Exportin 1-like protein; The sequences featured in this family are similar to a region close to the N-terminus of yeast exportin 1 (Xpo1, Crm1). This region is found just C-terminal to an importin-beta N-terminal domain (pfam03810) in many members of this family. Exportin 1 is a nuclear export receptor that interacts with leucine-rich nuclear export signal (NES) sequences, and Ran-GTP, and is involved in translocation of proteins out of the nucleus.


:

Pssm-ID: 462459  Cd Length: 147  Bit Score: 88.82  E-value: 1.66e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366267  55 SWKGCVQTLVEKYSNDVTSLPFLLEILTVLPEEVHS-RSLRIGANRRTEIIEDLAFYSSTVVSLLMTCVEKAG-TDEKML 132
Cdd:pfam08389  23 NWPTFFPDLISLLSSNPTGCELFLRILKVLPEEIFDfSRTSLTQDRNNRLKDLLRSNMEQILELLLQILEASQnANSELV 102

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2217366267 133 MKVFRCLGSWFNlgVLDSNFMANNKLLALLFEVLQQDKtssnLHEAASDCV 183
Cdd:pfam08389 103 EAVLKCLGSWLS--WIPIGLIVNNPLLNLLFSLLNDPD----LREAAVECL 147
 
Name Accession Description Interval E-value
Xpo1 pfam08389
Exportin 1-like protein; The sequences featured in this family are similar to a region close ...
 55-183 1.66e-20

Exportin 1-like protein; The sequences featured in this family are similar to a region close to the N-terminus of yeast exportin 1 (Xpo1, Crm1). This region is found just C-terminal to an importin-beta N-terminal domain (pfam03810) in many members of this family. Exportin 1 is a nuclear export receptor that interacts with leucine-rich nuclear export signal (NES) sequences, and Ran-GTP, and is involved in translocation of proteins out of the nucleus.


Pssm-ID: 462459  Cd Length: 147  Bit Score: 88.82  E-value: 1.66e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366267  55 SWKGCVQTLVEKYSNDVTSLPFLLEILTVLPEEVHS-RSLRIGANRRTEIIEDLAFYSSTVVSLLMTCVEKAG-TDEKML 132
Cdd:pfam08389  23 NWPTFFPDLISLLSSNPTGCELFLRILKVLPEEIFDfSRTSLTQDRNNRLKDLLRSNMEQILELLLQILEASQnANSELV 102

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2217366267 133 MKVFRCLGSWFNlgVLDSNFMANNKLLALLFEVLQQDKtssnLHEAASDCV 183
Cdd:pfam08389 103 EAVLKCLGSWLS--WIPIGLIVNNPLLNLLFSLLNDPD----LREAAVECL 147
 
Name Accession Description Interval E-value
Xpo1 pfam08389
Exportin 1-like protein; The sequences featured in this family are similar to a region close ...
 55-183 1.66e-20

Exportin 1-like protein; The sequences featured in this family are similar to a region close to the N-terminus of yeast exportin 1 (Xpo1, Crm1). This region is found just C-terminal to an importin-beta N-terminal domain (pfam03810) in many members of this family. Exportin 1 is a nuclear export receptor that interacts with leucine-rich nuclear export signal (NES) sequences, and Ran-GTP, and is involved in translocation of proteins out of the nucleus.


Pssm-ID: 462459  Cd Length: 147  Bit Score: 88.82  E-value: 1.66e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366267  55 SWKGCVQTLVEKYSNDVTSLPFLLEILTVLPEEVHS-RSLRIGANRRTEIIEDLAFYSSTVVSLLMTCVEKAG-TDEKML 132
Cdd:pfam08389  23 NWPTFFPDLISLLSSNPTGCELFLRILKVLPEEIFDfSRTSLTQDRNNRLKDLLRSNMEQILELLLQILEASQnANSELV 102

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2217366267 133 MKVFRCLGSWFNlgVLDSNFMANNKLLALLFEVLQQDKtssnLHEAASDCV 183
Cdd:pfam08389 103 EAVLKCLGSWLS--WIPIGLIVNNPLLNLLFSLLNDPD----LREAAVECL 147
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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