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Conserved domains on  [gi|2217267506|ref|XP_047276727|]
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T-lymphocyte surface antigen Ly-9 isoform X13 [Homo sapiens]

Protein Classification

Ig_SLAM-CD84_like_N domain-containing protein( domain architecture ID 11617245)

Ig_SLAM-CD84_like_N domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ig_SLAM-like_N cd16842
N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule ...
 53-151 1.17e-37

N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family and similar proteins. The SLAM family is a group of immune-cell specific receptors that can regulate both adaptive and innate immune responses. Members of this group include proteins such as CD84, SLAM (CD150), Ly-9 (CD229), NTB-A (ly-108, SLAM6), 19A (CRACC), and SLAMF9. The genes coding for the SLAM family are nested on chromosome 1, in humans at 1q23, and in mice at 1H2. The SLAM family is a subset of the CD2 family, which also includes CD2 and CD58 located on chromosome 1 at 1p13 in humans. In mice, CD2 is located on chromosome 3, and there is no CD58 homolog. The SLAM family proteins are organized as an extracellular domain with either two or four Ig-like domains, a single transmembrane segment, and a cytoplasmic region having Tyr-based motifs. The extracellular domain is organized as a membrane-distal Ig variable (IgV) domain that is responsible for ligand recognition and a membrane-proximal truncated Ig constant-2 (IgC2) domain.


:

Pssm-ID: 409517  Cd Length: 102  Bit Score: 130.90  E-value: 1.17e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217267506  53 TVVSGILGGSVTLPLNISVDTEIENVIWIGPKNALAFARPKE---NVTIMVKSYLGRLDITKWSYSLCISNLTLNDAGSY 129
Cdd:cd16842     1 KEVNGILGGSVTFPLNISDGQEIENITWSFKTSLAVIAPGEGgapEIIITDKSYKERLNISQNDYSLQISNLTMEDAGSY 80

                          90       100
                  ....*....|....*....|..
gi 2217267506 130 KAQINQRNFEVTTEEEFTLFVY 151
Cdd:cd16842    81 RARINTKNSRVTITKEFTLHIY 102
 
Name Accession Description Interval E-value
Ig_SLAM-like_N cd16842
N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule ...
 53-151 1.17e-37

N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family and similar proteins. The SLAM family is a group of immune-cell specific receptors that can regulate both adaptive and innate immune responses. Members of this group include proteins such as CD84, SLAM (CD150), Ly-9 (CD229), NTB-A (ly-108, SLAM6), 19A (CRACC), and SLAMF9. The genes coding for the SLAM family are nested on chromosome 1, in humans at 1q23, and in mice at 1H2. The SLAM family is a subset of the CD2 family, which also includes CD2 and CD58 located on chromosome 1 at 1p13 in humans. In mice, CD2 is located on chromosome 3, and there is no CD58 homolog. The SLAM family proteins are organized as an extracellular domain with either two or four Ig-like domains, a single transmembrane segment, and a cytoplasmic region having Tyr-based motifs. The extracellular domain is organized as a membrane-distal Ig variable (IgV) domain that is responsible for ligand recognition and a membrane-proximal truncated Ig constant-2 (IgC2) domain.


Pssm-ID: 409517  Cd Length: 102  Bit Score: 130.90  E-value: 1.17e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217267506  53 TVVSGILGGSVTLPLNISVDTEIENVIWIGPKNALAFARPKE---NVTIMVKSYLGRLDITKWSYSLCISNLTLNDAGSY 129
Cdd:cd16842     1 KEVNGILGGSVTFPLNISDGQEIENITWSFKTSLAVIAPGEGgapEIIITDKSYKERLNISQNDYSLQISNLTMEDAGSY 80

                          90       100
                  ....*....|....*....|..
gi 2217267506 130 KAQINQRNFEVTTEEEFTLFVY 151
Cdd:cd16842    81 RARINTKNSRVTITKEFTLHIY 102
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 52-151 6.93e-06

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 44.37  E-value: 6.93e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217267506  52 PTVVSGILGGSVTLP--LNISVDTEIENVIW------IGPKNALAFARPKENVTIMVKSYLGRLDITKWSYSLCISNLTL 123
Cdd:pfam07686   3 PREVTVALGGSVTLPctYSSSMSEASTSVYWyrqppgKGPTFLIAYYSNGSEEGVKKGRFSGRGDPSNGDGSLTIQNLTL 82

                          90       100
                  ....*....|....*....|....*...
gi 2217267506 124 NDAGSYKAQINQRNfEVTTEEEFTLFVY 151
Cdd:pfam07686  83 SDSGTYTCAVIPSG-EGVFGKGTRLTVL 109
 
Name Accession Description Interval E-value
Ig_SLAM-like_N cd16842
N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule ...
 53-151 1.17e-37

N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family and similar proteins. The SLAM family is a group of immune-cell specific receptors that can regulate both adaptive and innate immune responses. Members of this group include proteins such as CD84, SLAM (CD150), Ly-9 (CD229), NTB-A (ly-108, SLAM6), 19A (CRACC), and SLAMF9. The genes coding for the SLAM family are nested on chromosome 1, in humans at 1q23, and in mice at 1H2. The SLAM family is a subset of the CD2 family, which also includes CD2 and CD58 located on chromosome 1 at 1p13 in humans. In mice, CD2 is located on chromosome 3, and there is no CD58 homolog. The SLAM family proteins are organized as an extracellular domain with either two or four Ig-like domains, a single transmembrane segment, and a cytoplasmic region having Tyr-based motifs. The extracellular domain is organized as a membrane-distal Ig variable (IgV) domain that is responsible for ligand recognition and a membrane-proximal truncated Ig constant-2 (IgC2) domain.


Pssm-ID: 409517  Cd Length: 102  Bit Score: 130.90  E-value: 1.17e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217267506  53 TVVSGILGGSVTLPLNISVDTEIENVIWIGPKNALAFARPKE---NVTIMVKSYLGRLDITKWSYSLCISNLTLNDAGSY 129
Cdd:cd16842     1 KEVNGILGGSVTFPLNISDGQEIENITWSFKTSLAVIAPGEGgapEIIITDKSYKERLNISQNDYSLQISNLTMEDAGSY 80

                          90       100
                  ....*....|....*....|..
gi 2217267506 130 KAQINQRNFEVTTEEEFTLFVY 151
Cdd:cd16842    81 RARINTKNSRVTITKEFTLHIY 102
IgV_CD2_like_N cd05775
N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; ...
 50-151 1.12e-07

N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain (or domain 1) of T-cell surface antigen Clusters of Differentiation (CD) 2 and similar proteins. CD2 is a T-cell specific surface glycoprotein and is critically important for mediating adhesion between T cells and antigen-presenting cells or between cytolytic T cells and target cells. CD2 is located on chromosome 1 at 1p13 in humans and on chromosome 3 in mice. CD2 contains an extracellular domain with two or Ig-like domains, a single transmembrane segment, and a cytoplasmic region rich in proline and basic residues.


Pssm-ID: 409431  Cd Length: 98  Bit Score: 49.27  E-value: 1.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217267506  50 SAPTVVsGILGGSVTLPLNiSVDTEIENVIWIGPKNALAFARPKENVTIMvKSYLGRLDITKWSYSLCISNLTLNDAGSY 129
Cdd:cd05775     1 SSGEVY-GALGGNVTLTIS-SLQDDIDEIKWKKTKDKIVEWENNIGPTYF-GSFKDRVLLDKESGSLTIKNLTKEDSGTY 77

                          90       100
                  ....*....|....*....|..
gi 2217267506 130 KAQINQRNfEVTTEEEFTLFVY 151
Cdd:cd05775    78 ELEITSTN-GKVLSSKFTLEVL 98
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 52-151 6.93e-06

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 44.37  E-value: 6.93e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217267506  52 PTVVSGILGGSVTLP--LNISVDTEIENVIW------IGPKNALAFARPKENVTIMVKSYLGRLDITKWSYSLCISNLTL 123
Cdd:pfam07686   3 PREVTVALGGSVTLPctYSSSMSEASTSVYWyrqppgKGPTFLIAYYSNGSEEGVKKGRFSGRGDPSNGDGSLTIQNLTL 82

                          90       100
                  ....*....|....*....|....*...
gi 2217267506 124 NDAGSYKAQINQRNfEVTTEEEFTLFVY 151
Cdd:pfam07686  83 SDSGTYTCAVIPSG-EGVFGKGTRLTVL 109
IgV_1_Nectin-2_NecL-5_like_CD112_CD155 cd20989
First immunoglobulin variable (IgV) domain of nectin-2, nectin-like protein 5, and similar ...
 51-133 1.33e-03

First immunoglobulin variable (IgV) domain of nectin-2, nectin-like protein 5, and similar domains; The members here are composed of the second immunoglobulin (Ig) domain of nectin-2 (also known as poliovirus receptor related protein 2 or Cluster of Differentiation 112 (CD112)), nectin-like protein 5 (CD155), and similar proteins. Nectins and Nectin-like molecules are a family of Ca(2+)-independent immunoglobulin-like transmembrane glycoproteins belonging to the class of adhesion receptors, consisting of nine members (nectins 1 through 4 and nectin-like proteins 1 through 5). Nectins are synaptic cell adhesion molecules (CAMs) which facilitate adhesion and signaling at various intracellular junctions. Nectins form homophilic cis-dimers, followed by homophilic and heterophilic trans-dimers involved in cell-cell adhesion. Nectin-2 and nectin-3 localize at Sertoli-spermatid junctions where they form heterophilic trans-interactions between the cells that are essential for the formation and maintenance of the junctions and for spermatid development. CD155 is the fifth member in the nectin-like molecule family, and functions as the receptor of poliovirus; therefore, CD155 is also referred to as Necl-5, or PVR. In contrast to all other family members, CD155 lacks self-adhesion capacity, yet it shares with nectins the feature to interact with other nectins. For instance, CD155 heterophilically trans-interacts with nectin-3, thereby contributing significantly to the establishment of adherens junctions between epithelial cells. This group belongs to the Constant 1 (C1)-set of IgSF domains, which has one beta-sheet that is formed by strands A-B-E-D and the other strands by G-F-C-C'.


Pssm-ID: 409581  Cd Length: 112  Bit Score: 37.94  E-value: 1.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217267506  51 APTVVSGILGGSVTLPLNISV---DTEIENVIWIGPKNA--LAFARPKENVTI----MVKSYLGRLDITKWSYSLCISNL 121
Cdd:cd20989     5 VPPEVRGFLGGSVTLPCHLLPpnmVTHVSQVTWQRHDEHgsVAVFHPKQGPSFpeseRLSFVAARLGAELRNASLAMFGL 84

                          90
                  ....*....|..
gi 2217267506 122 TLNDAGSYKAQI 133
Cdd:cd20989    85 RVEDEGNYTCEF 96
IgV_1_PVR_like cd05718
First immunoglobulin variable (IgV) domain of poliovirus receptor (PVR, also known as CD155 ...
 51-129 3.79e-03

First immunoglobulin variable (IgV) domain of poliovirus receptor (PVR, also known as CD155 and necl-5), and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155 and nectin-like protein 5 (necl-5)). Poliovirus (PV) binds to its cellular receptor (PVR/CD155) to initiate infection. CD155 is a membrane-anchored, single-span glycoprotein; its extracellular region has three Ig-like domains. There are four different isotypes of CD155 (referred to as alpha, beta, gamma, and delta), that result from alternate splicing of the CD155 mRNA, and have identical extracellular domains. CD155-beta and CD155-gamma are secreted; CD155-alpha and CD155-delta are membrane-bound and function as PV receptors. The virus recognition site is contained in the amino-terminal domain, D1. Having the virus attachment site on the receptor distal from the plasma membrane may be important for successful initiation of infection of cells by the virus. CD155 binds in the poliovirus "canyon" with a footprint similar to that of the intercellular adhesion molecule-1 receptor on human rhinoviruses. This group also includes the first Ig-like domain of nectin-1 (also known as poliovirus receptor related protein(PVRL)1; CD111), nectin-3 (also known as PVRL 3), nectin-4 (also known as PVRL4; LNIR receptor)and DNAX accessory molecule 1 (DNAM-1; CD226).


Pssm-ID: 409383  Cd Length: 113  Bit Score: 36.66  E-value: 3.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217267506  51 APTVVSGILGGSVTLP--LNISVDTEIENVIWIGPKNA----LAFARPKENVTIMvKSYLGRLDITKWSY-----SLCIS 119
Cdd:cd05718     5 VPTEVTGFLGGSVTLPcsLTSPGTTKITQVTWMKIGAGssqnVAVFHPQYGPSVP-NPYAERVEFLAARLglrnaTLRIR 83

                          90
                  ....*....|
gi 2217267506 120 NLTLNDAGSY 129
Cdd:cd05718    84 NLRVEDEGNY 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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