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Conserved domains on  [gi|2217276170|ref|XP_047280788|]
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ankyrin repeat domain-containing protein 26 isoform X12 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CCDC144C pfam14915
CCDC144C protein coiled-coil region; This family includes the human protein CCDC144C and the ...
 880-1183 1.90e-160

CCDC144C protein coiled-coil region; This family includes the human protein CCDC144C and the ankyrin repeat domain-containing protein 26-like 1 found in eukaryotes. Its function remains unknown, however, it is known to contain a coiled-coil domain which corresponds to this region. The ankyrin repeat which features in this protein is a common amino acid motif.


:

Pssm-ID: 464371 [Multi-domain]  Cd Length: 304  Bit Score: 488.73  E-value: 1.90e-160
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  880 NSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLE 959
Cdd:pfam14915    1 NCMLQDEIAMLRLEIDTIKNQNQEKEKKYLEDIEILKEKNDDLQKTLKLNEETLTKTVFQYNGQLNVLKAENTMLNSKLE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  960 NEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKL 1039
Cdd:pfam14915   81 NEKQNKERLETEVESYRSRLAAAIQDHEQSQTSKRDLELAFQRERDEWLRLQDKMNFDVSNLRDENEILSQQLSKAESKA 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1040 NSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDA 1119
Cdd:pfam14915  161 NSLENELHRTRDALREKTLLLESVQRDLSQAQCQKKELEHMYQNEQDKVNKYIGKQESLEERLAQLQSENMLLRQQLEDA 240

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217276170 1120 HNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAER 1183
Cdd:pfam14915  241 QNKADAKEKTVIDIQDQFQDIVKKLQAESEKQVLLLEERNKELINECNHLKERLYQYEKEKAER 304
DUF3496 pfam12001
Domain of unknown function (DUF3496); This presumed domain is functionally uncharacterized. ...
 1489-1597 2.38e-56

Domain of unknown function (DUF3496); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is about 110 amino acids in length.


:

Pssm-ID: 463425 [Multi-domain]  Cd Length: 109  Bit Score: 190.65  E-value: 2.38e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1489 KSQMELRIKDLESELSKIKTSQEDFNKTELEKYKQLYLEELKVRKSLSSKLTKTNERLAEVNTKLLVEKQQSRSLFTTLT 1568
Cdd:pfam12001    1 RSQMELRIKDLESELSKMKTSQEDSNKIELEKYKQLYLEELKVRKSLSNKLNKTNERLAEVSTKLLVEKQQNRSLLSTLT 80

                           90       100
                   ....*....|....*....|....*....
gi 2217276170 1569 TRPVMEPPCVGNLNNSLDLNRKLIPRENL 1597
Cdd:pfam12001   81 TRPVLESPCVGNLNNSLVLNRNFIPRENL 109
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
44-210 4.51e-37

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 142.02  E-value: 4.51e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170   44 DRDLGKIHKAASAGNVAKVQQILLLRKNGLNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQC 123
Cdd:COG0666     51 DALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYN 130

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  124 QEEKCATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKA 203
Cdd:COG0666    131 GNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGA 210


                   ....*..
gi 2217276170  204 NVNAVDK 210
Cdd:COG0666    211 DVNAKDN 217
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 713-1380 4.22e-18

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 91.27  E-value: 4.22e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  713 ELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSL-----------NQEEEKRRNADTLYEKI--- 778
Cdd:TIGR02168  270 EELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLeeleaqleeleSKLDELAEELAELEEKLeel 349

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  779 REQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSR-----EQNARMLQDGILTNHLSKQK 853
Cdd:TIGR02168  350 KEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERlearlERLEDRRERLQQEIEELLKK 429

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  854 EIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKC------FEDLKIVKEKNEDLQKTIK 927
Cdd:TIGR02168  430 LEEAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELaqlqarLDSLERLQENLEGFSEGVK 509

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  928 QNEETLTQtISQYNGRLSVL--------TAENAMLNSKL-----ENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKR 994
Cdd:TIGR02168  510 ALLKNQSG-LSGILGVLSELisvdegyeAAIEAALGGRLqavvvENLNAAKKAIAFLKQNELGRVTFLPLDSIKGTEIQG 588

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  995 ELELAFQRARDECSRLQDKMNFD----------------VSNLKDNNEILSQQLFktESKLNSLEIEFHHTRDAL----R 1054
Cdd:TIGR02168  589 NDREILKNIEGFLGVAKDLVKFDpklrkalsyllggvlvVDDLDNALELAKKLRP--GYRIVTLDGDLVRPGGVItggsA 666

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1055 EKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQ 1134
Cdd:TIGR02168  667 KTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLE 746

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1135 DQfhaiVQKLQAESEKQSLLLEERNKELISECNHLKERqyqyENEKAEREVVVRQLQQELadtlkkQSMSEASLEVTSRY 1214
Cdd:TIGR02168  747 ER----IAQLSKELTELEAEIEELEERLEEAEEELAEA----EAEIEELEAQIEQLKEEL------KALREALDELRAEL 812

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1215 RiNLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQK----------- 1283
Cdd:TIGR02168  813 T-LLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNerasleealal 891

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1284 -NLLNANLSEDEKEQLKKLMELKQslecNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFsfhGDLKTSQFEMD 1362
Cdd:TIGR02168  892 lRSELEELSEELRELESKRSELRR----ELEELREKLAQLELRLEGLEVRIDNLQERLSEEYSLTL---EEAEALENKIE 964

                          730
                   ....*....|....*...
gi 2217276170 1363 IQINKLKHKIDDLTAELE 1380
Cdd:TIGR02168  965 DDEEEARRRLKRLENKIK 982
DR0291 super family cl34310
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1360-1533 1.99e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


The actual alignment was detected with superfamily member COG1579:

Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 44.92  E-value: 1.99e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1360 EMDIQINKLKHKIDDLTAELEtagskclHLDTKNQILQEELlsmKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELG 1439
Cdd:COG1579     14 ELDSELDRLEHRLKELPAELA-------ELEDELAALEARL---EAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLG 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1440 QVKQYKQ------EIE--ERARQEIAEKLKEVNLFLQAQAASQENLEQF---RENNFASMKSQMELRIKDLESELSKIKT 1508
Cdd:COG1579     84 NVRNNKEyealqkEIEslKRRISDLEDEILELMERIEELEEELAELEAElaeLEAELEEKKAELDEELAELEAELEELEA 163

                          170       180
                   ....*....|....*....|....*
gi 2217276170 1509 SQEDFNKTELEKYKQLYlEELKVRK 1533
Cdd:COG1579    164 EREELAAKIPPELLALY-ERIRKRK 187
 
Name Accession Description Interval E-value
CCDC144C pfam14915
CCDC144C protein coiled-coil region; This family includes the human protein CCDC144C and the ...
 880-1183 1.90e-160

CCDC144C protein coiled-coil region; This family includes the human protein CCDC144C and the ankyrin repeat domain-containing protein 26-like 1 found in eukaryotes. Its function remains unknown, however, it is known to contain a coiled-coil domain which corresponds to this region. The ankyrin repeat which features in this protein is a common amino acid motif.


Pssm-ID: 464371 [Multi-domain]  Cd Length: 304  Bit Score: 488.73  E-value: 1.90e-160
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  880 NSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLE 959
Cdd:pfam14915    1 NCMLQDEIAMLRLEIDTIKNQNQEKEKKYLEDIEILKEKNDDLQKTLKLNEETLTKTVFQYNGQLNVLKAENTMLNSKLE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  960 NEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKL 1039
Cdd:pfam14915   81 NEKQNKERLETEVESYRSRLAAAIQDHEQSQTSKRDLELAFQRERDEWLRLQDKMNFDVSNLRDENEILSQQLSKAESKA 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1040 NSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDA 1119
Cdd:pfam14915  161 NSLENELHRTRDALREKTLLLESVQRDLSQAQCQKKELEHMYQNEQDKVNKYIGKQESLEERLAQLQSENMLLRQQLEDA 240

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217276170 1120 HNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAER 1183
Cdd:pfam14915  241 QNKADAKEKTVIDIQDQFQDIVKKLQAESEKQVLLLEERNKELINECNHLKERLYQYEKEKAER 304
DUF3496 pfam12001
Domain of unknown function (DUF3496); This presumed domain is functionally uncharacterized. ...
 1489-1597 2.38e-56

Domain of unknown function (DUF3496); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is about 110 amino acids in length.


Pssm-ID: 463425 [Multi-domain]  Cd Length: 109  Bit Score: 190.65  E-value: 2.38e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1489 KSQMELRIKDLESELSKIKTSQEDFNKTELEKYKQLYLEELKVRKSLSSKLTKTNERLAEVNTKLLVEKQQSRSLFTTLT 1568
Cdd:pfam12001    1 RSQMELRIKDLESELSKMKTSQEDSNKIELEKYKQLYLEELKVRKSLSNKLNKTNERLAEVSTKLLVEKQQNRSLLSTLT 80

                           90       100
                   ....*....|....*....|....*....
gi 2217276170 1569 TRPVMEPPCVGNLNNSLDLNRKLIPRENL 1597
Cdd:pfam12001   81 TRPVLESPCVGNLNNSLVLNRNFIPRENL 109
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
44-210 4.51e-37

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 142.02  E-value: 4.51e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170   44 DRDLGKIHKAASAGNVAKVQQILLLRKNGLNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQC 123
Cdd:COG0666     51 DALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYN 130

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  124 QEEKCATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKA 203
Cdd:COG0666    131 GNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGA 210


                   ....*..
gi 2217276170  204 NVNAVDK 210
Cdd:COG0666    211 DVNAKDN 217
Ank_2 pfam12796
Ankyrin repeats (3 copies);
84-176 4.89e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 86.32  E-value: 4.89e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170   84 LHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHgADPNLADvHGNTALHYAVYNEDISVAT 163
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 2217276170  164 KLLLYDANIEAKN 176
Cdd:pfam12796   79 LLLEKGADINVKD 91
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 713-1380 4.22e-18

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 91.27  E-value: 4.22e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  713 ELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSL-----------NQEEEKRRNADTLYEKI--- 778
Cdd:TIGR02168  270 EELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLeeleaqleeleSKLDELAEELAELEEKLeel 349

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  779 REQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSR-----EQNARMLQDGILTNHLSKQK 853
Cdd:TIGR02168  350 KEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERlearlERLEDRRERLQQEIEELLKK 429

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  854 EIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKC------FEDLKIVKEKNEDLQKTIK 927
Cdd:TIGR02168  430 LEEAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELaqlqarLDSLERLQENLEGFSEGVK 509

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  928 QNEETLTQtISQYNGRLSVL--------TAENAMLNSKL-----ENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKR 994
Cdd:TIGR02168  510 ALLKNQSG-LSGILGVLSELisvdegyeAAIEAALGGRLqavvvENLNAAKKAIAFLKQNELGRVTFLPLDSIKGTEIQG 588

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  995 ELELAFQRARDECSRLQDKMNFD----------------VSNLKDNNEILSQQLFktESKLNSLEIEFHHTRDAL----R 1054
Cdd:TIGR02168  589 NDREILKNIEGFLGVAKDLVKFDpklrkalsyllggvlvVDDLDNALELAKKLRP--GYRIVTLDGDLVRPGGVItggsA 666

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1055 EKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQ 1134
Cdd:TIGR02168  667 KTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLE 746

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1135 DQfhaiVQKLQAESEKQSLLLEERNKELISECNHLKERqyqyENEKAEREVVVRQLQQELadtlkkQSMSEASLEVTSRY 1214
Cdd:TIGR02168  747 ER----IAQLSKELTELEAEIEELEERLEEAEEELAEA----EAEIEELEAQIEQLKEEL------KALREALDELRAEL 812

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1215 RiNLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQK----------- 1283
Cdd:TIGR02168  813 T-LLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNerasleealal 891

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1284 -NLLNANLSEDEKEQLKKLMELKQslecNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFsfhGDLKTSQFEMD 1362
Cdd:TIGR02168  892 lRSELEELSEELRELESKRSELRR----ELEELREKLAQLELRLEGLEVRIDNLQERLSEEYSLTL---EEAEALENKIE 964

                          730
                   ....*....|....*...
gi 2217276170 1363 IQINKLKHKIDDLTAELE 1380
Cdd:TIGR02168  965 DDEEEARRRLKRLENKIK 982
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 9-220 1.60e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 71.56  E-value: 1.60e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170    9 GESPLgSFARRQRSSAGGGGEPGEGAYsqPGYHVRDRDlGKIHKAASAGNVAKVQQILLLRKNGLNDRDKMNRTALHLAC 88
Cdd:PHA02875    35 GISPI-KLAMKFRDSEAIKLLMKHGAI--PDVKYPDIE-SELHDAVEEGDVKAVEELLDLGKFADDVFYKDGMTPLHLAT 110

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170   89 ANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLY 168
Cdd:PHA02875   111 ILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDS 190

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2217276170  169 DANIEAKNKD-DLTPLLLAVSGKKQQMVEFLIKKKANVNAVDKLESSHQLISE 220
Cdd:PHA02875   191 GANIDYFGKNgCVAALCYAIENNKIDIVRLFIKRGADCNIMFMIEGEECTILD 243
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 719-1500 1.66e-11

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 69.38  E-value: 1.66e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  719 IKKMEDKVNVLQRELSETKEIKsqlEHQKVEWERELCSLRFSLnQEEEKRRNAdtlyekiREQLRRKEEQYRKEVevKQQ 798
Cdd:pfam15921   80 LEEYSHQVKDLQRRLNESNELH---EKQKFYLRQSVIDLQTKL-QEMQMERDA-------MADIRRRESQSQEDL--RNQ 146

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  799 LELSLQTLEMElRTVKSNLnqvvqeRNDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQ-KKMNSENSHSHEEEKDL- 876
Cdd:pfam15921  147 LQNTVHELEAA-KCLKEDM------LEDSNTQIEQLRKMMLSHEGVLQEIRSILVDFEEASgKKIYEHDSMSTMHFRSLg 219

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  877 SHKNSMLQE---EIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNED-LQKTIKQNE---ETLTQTISQYNGRLSVLTA 949
Cdd:pfam15921  220 SAISKILREldtEISYLKGRIFPVEDQLEALKSESQNKIELLLQQHQDrIEQLISEHEveiTGLTEKASSARSQANSIQS 299

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  950 ENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHD-----RDQSETSKRELELA---FQRARDEcsrlQDKMNFDVSNL 1021
Cdd:pfam15921  300 QLEIIQEQARNQNSMYMRQLSDLESTVSQLRSELREakrmyEDKIEELEKQLVLAnseLTEARTE----RDQFSQESGNL 375

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1022 KDNNEILSQQLFKTESKLnSLE---------------IEFHHTRDALREKTLGLERVQKDLS--QTQCQmKEMEQKYQNE 1084
Cdd:pfam15921  376 DDQLQKLLADLHKREKEL-SLEkeqnkrlwdrdtgnsITIDHLRRELDDRNMEVQRLEALLKamKSECQ-GQMERQMAAI 453

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1085 QvkvnkyiGKQESVEERLS---QLQSENMLLRQQLDDAHNKA---DNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEER 1158
Cdd:pfam15921  454 Q-------GKNESLEKVSSltaQLESTKEMLRKVVEELTAKKmtlESSERTVSDLTASLQEKERAIEATNAEITKLRSRV 526

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1159 NKELiSECNHLKERQYQYENEKAErevvvrqlqqelADTLKKQsMSEASlEVTSRYRINLEDETQdLKKKLGQIRNQLQe 1238
Cdd:pfam15921  527 DLKL-QELQHLKNEGDHLRNVQTE------------CEALKLQ-MAEKD-KVIEILRQQIENMTQ-LVGQHGRTAGAMQ- 589

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1239 aqdrhTEAVRCAEKMQDHKQKLEKdnakLKVTVKKQMDKIEELQknllnANLSEDEKEQLKKLMELKQSLECnldqemKK 1318
Cdd:pfam15921  590 -----VEKAQLEKEINDRRLELQE----FKILKDKKDAKIRELE-----ARVSDLELEKVKLVNAGSERLRA------VK 649

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1319 NVELEREitGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMDIQINKLKHKIDDLTAELETAGS-------------- 1384
Cdd:pfam15921  650 DIKQERD--QLLNEVKTSRNELNSLSEDYEVLKRNFRNKSEEMETTTNKLKMQLKSAQSELEQTRNtlksmegsdghamk 727

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1385 --------------KCLHLDTKNQILQEellSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEE 1450
Cdd:pfam15921  728 vamgmqkqitakrgQIDALQSKIQFLEE---AMTNANKEKHFLKEEKNKLSQELSTVATEKNKMAGELEVLRSQERRLKE 804

                          810       820       830       840       850
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2217276170 1451 R-ARQEIAekLKEVNLflqaQAASQENLEQFRENNFASMKSQMELRIKDLE 1500
Cdd:pfam15921  805 KvANMEVA--LDKASL----QFAECQDIIQRQEQESVRLKLQHTLDVKELQ 849
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1115-1553 3.23e-11

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 68.55  E-value: 3.23e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1115 QLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLL--LEERNKELISECNHL--KERQYQYENEKAEREV----- 1185
Cdd:PRK03918   156 GLDDYENAYKNLGEVIKEIKRRIERLEKFIKRTENIEELIkeKEKELEEVLREINEIssELPELREELEKLEKEVkelee 235

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1186 ---VVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIrNQLQEAQDRHTEAVRCAEKMQDHKQKLEK 1262
Cdd:PRK03918   236 lkeEIEELEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKEL-KELKEKAEEYIKLSEFYEEYLDELREIEK 314

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1263 DNAKLKV---TVKKQMDKIEELQKNLlnANLSEDEKEQLKKLMELKQSLEcNLDQEMKKNVELEREITGFKNL-LKMTRK 1338
Cdd:PRK03918   315 RLSRLEEeinGIEERIKELEEKEERL--EELKKKLKELEKRLEELEERHE-LYEEAKAKKEELERLKKRLTGLtPEKLEK 391

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1339 KLNEYENGEFSFHGDLKtsqfEMDIQINKLKHKIDDLTA---ELETAGSKC------LHLDTKNQILQEELLSMKTVQKK 1409
Cdd:PRK03918   392 ELEELEKAKEEIEEEIS----KITARIGELKKEIKELKKaieELKKAKGKCpvcgreLTEEHRKELLEEYTAELKRIEKE 467

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1410 CEKLQKNKKKLEQEVINLRSHI--ERNMVELGQVKQYKQEIEER----------ARQEIAEKLKEVNLFLQAQAASQENl 1477
Cdd:PRK03918   468 LKEIEEKERKLRKELRELEKVLkkESELIKLKELAEQLKELEEKlkkynleeleKKAEEYEKLKEKLIKLKGEIKSLKK- 546

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1478 EQFRENNFASMKSQMELRIKDLESELSKIKT--------SQEDFNKT--ELEKYKQLYLE----------ELKVRKSLSS 1537
Cdd:PRK03918   547 ELEKLEELKKKLAELEKKLDELEEELAELLKeleelgfeSVEELEERlkELEPFYNEYLElkdaekelerEEKELKKLEE 626

                          490
                   ....*....|....*.
gi 2217276170 1538 KLTKTNERLAEVNTKL 1553
Cdd:PRK03918   627 ELDKAFEELAETEKRL 642
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 706-1238 6.54e-11

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 67.65  E-value: 6.54e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  706 ELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRK 785
Cdd:COG1196    221 ELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARL 300

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  786 EEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQKKMNSE 865
Cdd:COG1196    301 EQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEE 380

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  866 -----NSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKcfEDLKIVKEKNEDLQKTIKQNEETLTQTISQY 940
Cdd:COG1196    381 leelaEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELE--EALAELEEEEEEEEEALEEAAEEEAELEEEE 458

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  941 NGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDEC------------- 1007
Cdd:COG1196    459 EALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAvavligveaayea 538

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1008 -------SRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEfhhtRDALREKTLGLERVQKDLSQTQCQMKEMEQK 1080
Cdd:COG1196    539 aleaalaAALQNIVVEDDEVAAAAIEYLKAAKAGRATFLPLDKIR----ARAALAAALARGAIGAAVDLVASDLREADAR 614

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1081 Y---QNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQS---LL 1154
Cdd:COG1196    615 YyvlGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAeeeLE 694

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1155 LEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRN 1234
Cdd:COG1196    695 LEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELERLER 774


                   ....
gi 2217276170 1235 QLQE 1238
Cdd:COG1196    775 EIEA 778
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1036-1344 5.62e-10

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 64.57  E-value: 5.62e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1036 ESKLNSLEIEfhhTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQ 1115
Cdd:COG1196    199 ERQLEPLERQ---AEKAERYRELKEELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLE 275

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1116 LDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSlLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELA 1195
Cdd:COG1196    276 LEELELELEEAQAEEYELLAELARLEQDIARLEERRR-ELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELE 354

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1196 DTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQM 1275
Cdd:COG1196    355 EAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELE 434

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1276 DKIEELQKNLLNANLSEDEKEQ-LKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYE 1344
Cdd:COG1196    435 EEEEEEEEALEEAAEEEAELEEeEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYE 504
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 707-1143 4.68e-09

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 61.19  E-value: 4.68e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  707 LKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKE 786
Cdd:TIGR04523  194 NKLLKLELLLSNLKKKIQKNKSLESQISELKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQNKIKKQLSEKQ 273

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  787 EQYRKEVEVKQQLELSLQTLEMEL------------RTVKSNLNQVVQERNDAQRQLSR-EQNARMLQDGIL-------- 845
Cdd:TIGR04523  274 KELEQNNKKIKELEKQLNQLKSEIsdlnnqkeqdwnKELKSELKNQEKKLEEIQNQISQnNKIISQLNEQISqlkkeltn 353

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  846 --TNHLSKQKEIEMAQKKMNSENshshEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKcfedLKIVKEKNEDLQ 923
Cdd:TIGR04523  354 seSENSEKQRELEEKQNEIEKLK----KENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQ----IKKLQQEKELLE 425

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  924 KTIKQneetLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSE---TSKRELELAF 1000
Cdd:TIGR04523  426 KEIER----LKETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESLETQLKVLSRSINKIKQNLEQKQkelKSKEKELKKL 501

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1001 QRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLE-----IEFHHTRDALREKTLG-------LERVQKDLS 1068
Cdd:TIGR04523  502 NEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEKESKISDLEdelnkDDFELKKENLEKEIDEknkeieeLKQTQKSLK 581

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2217276170 1069 QTQCQMKEMEQKYQNEQVKVNK----YIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQK 1143
Cdd:TIGR04523  582 KKQEEKQELIDQKEKEKKDLIKeieeKEKKISSLEKELEKAKKENEKLSSIIKNIKSKKNKLKQEVKQIKETIKEIRNK 660
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
766-1334 2.96e-08

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 58.92  E-value: 2.96e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  766 EKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSR-EQNARMLQdgi 844
Cdd:PRK03918   158 DDYENAYKNLGEVIKEIKRRIERLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREELEKlEKEVKELE--- 234

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  845 ltnhlSKQKEIEMAQKKMNSENSHSHEEEKDLSHknsmLQEEIAMLRLEIDTIKNQNQE-----KEKKCFEDLKIVKEKN 919
Cdd:PRK03918   235 -----ELKEEIEELEKELESLEGSKRKLEEKIRE----LEERIEELKKEIEELEEKVKElkelkEKAEEYIKLSEFYEEY 305

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  920 EDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLE----------------AEVESYHSRLAA-- 981
Cdd:PRK03918   306 LDELREIEKRLSRLEEEINGIEERIKELEEKEERLEELKKKLKELEKRLEeleerhelyeeakakkEELERLKKRLTGlt 385

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  982 ---AIHDRDQSETSKRELELAFQRARDECSRLQDKmnfdVSNLKDNNEILSQQlfKTESKLNSLEIEFHHTRDALREKTL 1058
Cdd:PRK03918   386 pekLEKELEELEKAKEEIEEEISKITARIGELKKE----IKELKKAIEELKKA--KGKCPVCGRELTEEHRKELLEEYTA 459

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1059 GLERVQKDLSQTqcqmKEMEQKYQNEQVKVNKYIGKQ-------------ESVEERLSQLQSENM--------LLRQQLD 1117
Cdd:PRK03918   460 ELKRIEKELKEI----EEKERKLRKELRELEKVLKKEseliklkelaeqlKELEEKLKKYNLEELekkaeeyeKLKEKLI 535

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1118 DAHNKADNKEKTVINIQD---QFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYEnEKAEREVVVRQLQQEL 1194
Cdd:PRK03918   536 KLKGEIKSLKKELEKLEElkkKLAELEKKLDELEEELAELLKELEELGFESVEELEERLKELE-PFYNEYLELKDAEKEL 614

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1195 ADTLKKQSMSEASLEVTsryrinlEDETQDLKKKLGQIRNQLQEAQDRHTEAVRcaEKMQDHKQKLEKDNAKLKVTVKKQ 1274
Cdd:PRK03918   615 EREEKELKKLEEELDKA-------FEELAETEKRLEELRKELEELEKKYSEEEY--EELREEYLELSRELAGLRAELEEL 685

                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1275 MDKIEELQKNLlnanlsEDEKEQLKKLMELKQSLEcNLDQEMKKNVELEREITGFKNLLK 1334
Cdd:PRK03918   686 EKRREEIKKTL------EKLKEELEEREKAKKELE-KLEKALERVEELREKVKKYKALLK 738
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 82-202 6.02e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 51.17  E-value: 6.02e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170   82 TALHLACANGHPEVVTLLVDRKCQLN------VCDNENRTALMK--------AVQCQEEKCATILLEHGADPNLADVHGN 147
Cdd:cd22192     91 TALHIAVVNQNLNLVRELIARGADVVspratgTFFRPGPKNLIYygehplsfAACVGNEEIVRLLIEHGADIRAQDSLGN 170

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2217276170  148 TALHYAVYNEDISVATK----LLLYDANIEA------KNKDDLTPLLLAVSGKKQQMVEFLIKKK 202
Cdd:cd22192    171 TVLHILVLQPNKTFACQmydlILSYDKEDDLqpldlvPNNQGLTPFKLAAKEGNIVMFQHLVQKR 235
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 82-202 1.28e-05

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 50.08  E-value: 1.28e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170   82 TALHLACANGHPEVVTLLVDRKCQLNV---CD-------------NENRTALMKAVQcqEEKCATILLEHGADPNLADVH 145
Cdd:TIGR00870  130 TALHLAAHRQNYEIVKLLLERGASVPAracGDffvksqgvdsfyhGESPLNAAACLG--SPSIVALLSEDPADILTADSL 207

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217276170  146 GNTALHYAVYNEDISVATK---------LLLYDANI-------EAKNKDDLTPLLLAVSGKKQQMVEFLIKKK 202
Cdd:TIGR00870  208 GNTLLHLLVMENEFKAEYEelscqmynfALSLLDKLrdskeleVILNHQGLTPLKLAAKEGRIVLFRLKLAIK 280
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1360-1533 1.99e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 44.92  E-value: 1.99e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1360 EMDIQINKLKHKIDDLTAELEtagskclHLDTKNQILQEELlsmKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELG 1439
Cdd:COG1579     14 ELDSELDRLEHRLKELPAELA-------ELEDELAALEARL---EAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLG 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1440 QVKQYKQ------EIE--ERARQEIAEKLKEVNLFLQAQAASQENLEQF---RENNFASMKSQMELRIKDLESELSKIKT 1508
Cdd:COG1579     84 NVRNNKEyealqkEIEslKRRISDLEDEILELMERIEELEEELAELEAElaeLEAELEEKKAELDEELAELEAELEELEA 163

                          170       180
                   ....*....|....*....|....*
gi 2217276170 1509 SQEDFNKTELEKYKQLYlEELKVRK 1533
Cdd:COG1579    164 EREELAAKIPPELLALY-ERIRKRK 187
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
 1364-1524 5.20e-04

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 44.82  E-value: 5.20e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1364 QINKLKHKIDDLTAELEtagSKCLHLDTKNQILQEELlsmKTVQKKCEKLQKNKKKLEQEVINLRSHIErnmvelgqvKQ 1443
Cdd:PRK00409   510 LIGEDKEKLNELIASLE---ELERELEQKAEEAEALL---KEAEKLKEELEEKKEKLQEEEDKLLEEAE---------KE 574

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1444 YKQEIEErARQEIAEKLKEVNLFLQAQAASQenleqfRENNFASMKSQMELRIKDLESELSKIKTSQEDFNKTELEKYKQ 1523
Cdd:PRK00409   575 AQQAIKE-AKKEADEIIKELRQLQKGGYASV------KAHELIEARKRLNKANEKKEKKKKKQKEKQEELKVGDEVKYLS 647


                   .
gi 2217276170 1524 L 1524
Cdd:PRK00409   648 L 648
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 79-108 8.37e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 38.34  E-value: 8.37e-04
                            10        20        30
                    ....*....|....*....|....*....|
gi 2217276170    79 MNRTALHLACANGHPEVVTLLVDRKCQLNV 108
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
EzrA pfam06160
Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like ...
 1226-1558 6.13e-03

Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like cell-division protein FtsZ polymerizes into a ring structure that establishes the location of the nascent division site. EzrA modulates the frequency and position of FtsZ ring formation. The structure contains 5 spectrin like alpha helical repeats.


Pssm-ID: 428797 [Multi-domain]  Cd Length: 542  Bit Score: 40.99  E-value: 6.13e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1226 KKKLGQIRNQLQEAQDRhteavrcAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLS-------------- 1291
Cdd:pfam06160   85 KKALDEIEELLDDIEED-------IKQILEELDELLESEEKNREEVEELKDKYRELRKTLLANRFSygpaidelekqlae 157

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1292 -EDEKEQLKKLMELKQSLECN--LDQEMKKNVELEREITGFKNLLKMTRK----KLNEYENGefsfHGDLKTSQF----- 1359
Cdd:pfam06160  158 iEEEFSQFEELTESGDYLEARevLEKLEEETDALEELMEDIPPLYEELKTelpdQLEELKEG----YREMEEEGYalehl 233

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1360 EMDIQINKLKHKIDDLTAELETagskcLHLDT---KNQILQEELLSM-----------KTVQKKCEKLQKNKKKLEQEVI 1425
Cdd:pfam06160  234 NVDKEIQQLEEQLEENLALLEN-----LELDEaeeALEEIEERIDQLydllekevdakKYVEKNLPEIEDYLEHAEEQNK 308

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1426 NLRSHIER-------NMVELGQVKQYKQEIEerarqEIAEKLKEVNLFLQAQAASQenleqfrennfasmkSQMELRIKD 1498
Cdd:pfam06160  309 ELKEELERvqqsytlNENELERVRGLEKQLE-----ELEKRYDEIVERLEEKEVAY---------------SELQEELEE 368

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1499 LESELSKIKTSQEDFNktelEKYKQLYLEELKVRKslssKLTKTNERLAEVntKLLVEKQ 1558
Cdd:pfam06160  369 ILEQLEEIEEEQEEFK----ESLQSLRKDELEARE----KLDEFKLELREI--KRLVEKS 418
 
Name Accession Description Interval E-value
CCDC144C pfam14915
CCDC144C protein coiled-coil region; This family includes the human protein CCDC144C and the ...
 880-1183 1.90e-160

CCDC144C protein coiled-coil region; This family includes the human protein CCDC144C and the ankyrin repeat domain-containing protein 26-like 1 found in eukaryotes. Its function remains unknown, however, it is known to contain a coiled-coil domain which corresponds to this region. The ankyrin repeat which features in this protein is a common amino acid motif.


Pssm-ID: 464371 [Multi-domain]  Cd Length: 304  Bit Score: 488.73  E-value: 1.90e-160
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  880 NSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLE 959
Cdd:pfam14915    1 NCMLQDEIAMLRLEIDTIKNQNQEKEKKYLEDIEILKEKNDDLQKTLKLNEETLTKTVFQYNGQLNVLKAENTMLNSKLE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  960 NEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKL 1039
Cdd:pfam14915   81 NEKQNKERLETEVESYRSRLAAAIQDHEQSQTSKRDLELAFQRERDEWLRLQDKMNFDVSNLRDENEILSQQLSKAESKA 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1040 NSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDA 1119
Cdd:pfam14915  161 NSLENELHRTRDALREKTLLLESVQRDLSQAQCQKKELEHMYQNEQDKVNKYIGKQESLEERLAQLQSENMLLRQQLEDA 240

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217276170 1120 HNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAER 1183
Cdd:pfam14915  241 QNKADAKEKTVIDIQDQFQDIVKKLQAESEKQVLLLEERNKELINECNHLKERLYQYEKEKAER 304
DUF3496 pfam12001
Domain of unknown function (DUF3496); This presumed domain is functionally uncharacterized. ...
 1489-1597 2.38e-56

Domain of unknown function (DUF3496); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is about 110 amino acids in length.


Pssm-ID: 463425 [Multi-domain]  Cd Length: 109  Bit Score: 190.65  E-value: 2.38e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1489 KSQMELRIKDLESELSKIKTSQEDFNKTELEKYKQLYLEELKVRKSLSSKLTKTNERLAEVNTKLLVEKQQSRSLFTTLT 1568
Cdd:pfam12001    1 RSQMELRIKDLESELSKMKTSQEDSNKIELEKYKQLYLEELKVRKSLSNKLNKTNERLAEVSTKLLVEKQQNRSLLSTLT 80

                           90       100
                   ....*....|....*....|....*....
gi 2217276170 1569 TRPVMEPPCVGNLNNSLDLNRKLIPRENL 1597
Cdd:pfam12001   81 TRPVLESPCVGNLNNSLVLNRNFIPRENL 109
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
44-210 4.51e-37

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 142.02  E-value: 4.51e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170   44 DRDLGKIHKAASAGNVAKVQQILLLRKNGLNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQC 123
Cdd:COG0666     51 DALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYN 130

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  124 QEEKCATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKA 203
Cdd:COG0666    131 GNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGA 210


                   ....*..
gi 2217276170  204 NVNAVDK 210
Cdd:COG0666    211 DVNAKDN 217
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
50-218 4.60e-36

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 139.32  E-value: 4.60e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170   50 IHKAASAGNVAKVQQiLLLRKNGLNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCA 129
Cdd:COG0666     91 LHAAARNGDLEIVKL-LLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIV 169

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  130 TILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKANVNAVD 209
Cdd:COG0666    170 KLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKD 249


                   ....*....
gi 2217276170  210 KLESSHQLI 218
Cdd:COG0666    250 KDGLTALLL 258
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
50-210 7.25e-30

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 121.21  E-value: 7.25e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170   50 IHKAASAGNVAKVQqilLLRKNG--LNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEK 127
Cdd:COG0666    124 LHLAAYNGNLEIVK---LLLEAGadVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLE 200

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  128 CATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKANVNA 207
Cdd:COG0666    201 IVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAA 280


                   ...
gi 2217276170  208 VDK 210
Cdd:COG0666    281 ALL 283
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
44-210 2.86e-27

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 113.51  E-value: 2.86e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170   44 DRDLGKIHKAASAGNVAKVQQILLLRKNGLNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQC 123
Cdd:COG0666     18 LLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARN 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  124 QEEKCATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKA 203
Cdd:COG0666     98 GDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGA 177


                   ....*..
gi 2217276170  204 NVNAVDK 210
Cdd:COG0666    178 DVNARDN 184
Ank_2 pfam12796
Ankyrin repeats (3 copies);
84-176 4.89e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 86.32  E-value: 4.89e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170   84 LHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHgADPNLADvHGNTALHYAVYNEDISVAT 163
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 2217276170  164 KLLLYDANIEAKN 176
Cdd:pfam12796   79 LLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
50-143 1.85e-19

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 84.40  E-value: 1.85e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170   50 IHKAASAGNVAKVQQiLLLRKNGLNDRDKMNRTALHLACANGHPEVVTLLVDrKCQLNVCDNeNRTALMKAVQCQEEKCA 129
Cdd:pfam12796    1 LHLAAKNGNLELVKL-LLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDN-GRTALHYAARSGHLEIV 77

                           90
                   ....*....|....
gi 2217276170  130 TILLEHGADPNLAD 143
Cdd:pfam12796   78 KLLLEKGADINVKD 91
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
50-183 1.71e-18

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 87.70  E-value: 1.71e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170   50 IHKAASAGNVAKVQqiLLLRKNG-LNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKC 128
Cdd:COG0666    157 LHLAAANGNLEIVK--LLLEAGAdVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEI 234

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2217276170  129 ATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPL 183
Cdd:COG0666    235 VKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 713-1380 4.22e-18

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 91.27  E-value: 4.22e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  713 ELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSL-----------NQEEEKRRNADTLYEKI--- 778
Cdd:TIGR02168  270 EELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLeeleaqleeleSKLDELAEELAELEEKLeel 349

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  779 REQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSR-----EQNARMLQDGILTNHLSKQK 853
Cdd:TIGR02168  350 KEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERlearlERLEDRRERLQQEIEELLKK 429

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  854 EIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKC------FEDLKIVKEKNEDLQKTIK 927
Cdd:TIGR02168  430 LEEAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELaqlqarLDSLERLQENLEGFSEGVK 509

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  928 QNEETLTQtISQYNGRLSVL--------TAENAMLNSKL-----ENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKR 994
Cdd:TIGR02168  510 ALLKNQSG-LSGILGVLSELisvdegyeAAIEAALGGRLqavvvENLNAAKKAIAFLKQNELGRVTFLPLDSIKGTEIQG 588

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  995 ELELAFQRARDECSRLQDKMNFD----------------VSNLKDNNEILSQQLFktESKLNSLEIEFHHTRDAL----R 1054
Cdd:TIGR02168  589 NDREILKNIEGFLGVAKDLVKFDpklrkalsyllggvlvVDDLDNALELAKKLRP--GYRIVTLDGDLVRPGGVItggsA 666

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1055 EKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQ 1134
Cdd:TIGR02168  667 KTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLE 746

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1135 DQfhaiVQKLQAESEKQSLLLEERNKELISECNHLKERqyqyENEKAEREVVVRQLQQELadtlkkQSMSEASLEVTSRY 1214
Cdd:TIGR02168  747 ER----IAQLSKELTELEAEIEELEERLEEAEEELAEA----EAEIEELEAQIEQLKEEL------KALREALDELRAEL 812

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1215 RiNLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQK----------- 1283
Cdd:TIGR02168  813 T-LLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNerasleealal 891

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1284 -NLLNANLSEDEKEQLKKLMELKQslecNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFsfhGDLKTSQFEMD 1362
Cdd:TIGR02168  892 lRSELEELSEELRELESKRSELRR----ELEELREKLAQLELRLEGLEVRIDNLQERLSEEYSLTL---EEAEALENKIE 964

                          730
                   ....*....|....*...
gi 2217276170 1363 IQINKLKHKIDDLTAELE 1380
Cdd:TIGR02168  965 DDEEEARRRLKRLENKIK 982
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 706-1524 1.23e-17

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 89.73  E-value: 1.23e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  706 ELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRK 785
Cdd:TIGR02168  221 ELRELELALLVLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRL 300

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  786 EEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLsreqnarmlqDGILTNHLSKQKEIEMAQKKMnsE 865
Cdd:TIGR02168  301 EQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKL----------EELKEELESLEAELEELEAEL--E 368

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  866 NSHSHEEEKDLSHKNsmLQEEIAMLRLEIDTIKNQNQEKEKKcfedLKIVKEKNEDLQKTIKQNEETLTqtisqyNGRLS 945
Cdd:TIGR02168  369 ELESRLEELEEQLET--LRSKVAQLELQIASLNNEIERLEAR----LERLEDRRERLQQEIEELLKKLE------EAELK 436

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  946 VLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQsetSKRELELAFQRARDECSRLQDKMNF--DVSNLKD 1023
Cdd:TIGR02168  437 ELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDA---AERELAQLQARLDSLERLQENLEGFseGVKALLK 513

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1024 NNEILSQ------QLFKTESKLnsleiefhhtRDALrEKTLGlERVQKDLSQT-QCQMKEMEQKYQNEQVKVN----KYI 1092
Cdd:TIGR02168  514 NQSGLSGilgvlsELISVDEGY----------EAAI-EAALG-GRLQAVVVENlNAAKKAIAFLKQNELGRVTflplDSI 581

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1093 GKQESVEERLSQLQSENMLLRQQLDdaHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNkeLISECNHLKER 1172
Cdd:TIGR02168  582 KGTEIQGNDREILKNIEGFLGVAKD--LVKFDPKLRKALSYLLGGVLVVDDLDNALELAKKLRPGYR--IVTLDGDLVRP 657

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1173 QYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEK 1252
Cdd:TIGR02168  658 GGVITGGSAKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLAR 737

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1253 MQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLlnanlsEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNL 1332
Cdd:TIGR02168  738 LEAEVEQLEERIAQLSKELTELEAEIEELEERL------EEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAE 811

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1333 LKMTRKKLNEYENGEFSF---HGDLKTSQFEMDIQINKLKHKIDDLTAELETAgskclhldtknQILQEELlsmktvQKK 1409
Cdd:TIGR02168  812 LTLLNEEAANLRERLESLerrIAATERRLEDLEEQIEELSEDIESLAAEIEEL-----------EELIEEL------ESE 874

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1410 CEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIeERARQEIAEKLKEVNLFLQ-AQAASQENLEQFREN----- 1483
Cdd:TIGR02168  875 LEALLNERASLEEALALLRSELEELSEELRELESKRSEL-RRELEELREKLAQLELRLEgLEVRIDNLQERLSEEysltl 953

                          810       820       830       840
                   ....*....|....*....|....*....|....*....|....*
gi 2217276170 1484 -NFASMKSQMELRIKDLESELSKIKTSQEDF---NKTELEKYKQL 1524
Cdd:TIGR02168  954 eEAEALENKIEDDEEEARRRLKRLENKIKELgpvNLAAIEEYEEL 998
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
65-210 3.67e-17

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 83.85  E-value: 3.67e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170   65 ILLLRKNGLNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPNLADV 144
Cdd:COG0666      6 LLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDD 85

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217276170  145 HGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKANVNAVDK 210
Cdd:COG0666     86 GGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDN 151
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 719-1525 3.03e-16

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 85.11  E-value: 3.03e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  719 IKKMEDKVNVLQRELSET---KEIKSQLEhqkvEWERELCSLRFslNQEEEKRrnadtlyEKIREQLRRKEEQYRKEVEV 795
Cdd:TIGR02168  195 LNELERQLKSLERQAEKAeryKELKAELR----ELELALLVLRL--EELREEL-------EELQEELKEAEEELEELTAE 261

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  796 KQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSR-EQNARMLQDGiLTNHLSKQKEIEMAQKKMNSENSHSHEEEK 874
Cdd:TIGR02168  262 LQELEEKLEELRLEVSELEEEIEELQKELYALANEISRlEQQKQILRER-LANLERQLEELEAQLEELESKLDELAEELA 340

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  875 DLSHKNSMLQEEIAMLRLEIDTIKNQNQE---KEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQ---TISQYNGRLSVLT 948
Cdd:TIGR02168  341 ELEEKLEELKEELESLEAELEELEAELEElesRLEELEEQLETLRSKVAQLELQIASLNNEIERleaRLERLEDRRERLQ 420

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  949 AENAMLNSKLENEKQSK-----ERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFdVSNLKD 1023
Cdd:TIGR02168  421 QEIEELLKKLEEAELKElqaelEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDS-LERLQE 499

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1024 NNEILSQ---QLFKTESKLNSLE------IEFHHTRDALREKTLGlERVQKDLSQT-QCQMKEMEQKYQNEQVKVN---- 1089
Cdd:TIGR02168  500 NLEGFSEgvkALLKNQSGLSGILgvlselISVDEGYEAAIEAALG-GRLQAVVVENlNAAKKAIAFLKQNELGRVTflpl 578

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1090 KYIGKQESVEERLSQLQSENMLLRQQLDdaHNKADNKEKTVINIQDQFHAIVQKLQ------------------------ 1145
Cdd:TIGR02168  579 DSIKGTEIQGNDREILKNIEGFLGVAKD--LVKFDPKLRKALSYLLGGVLVVDDLDnalelakklrpgyrivtldgdlvr 656

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1146 --------AESEKQSLL--------LEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLE 1209
Cdd:TIGR02168  657 pggvitggSAKTNSSILerrreieeLEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLA 736

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1210 VTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLlnan 1289
Cdd:TIGR02168  737 RLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAEL---- 812

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1290 lsEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMD---IQIN 1366
Cdd:TIGR02168  813 --TLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERAsleEALA 890

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1367 KLKHKIDDLTAELETAGSKCLHLDTKNQILQEELLSMKTVQKKCE-KLQKNKKKL-EQEVINLRSHIERNMVELGQVKQY 1444
Cdd:TIGR02168  891 LLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEvRIDNLQERLsEEYSLTLEEAEALENKIEDDEEEA 970

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1445 KQEIeERARQEIAEkLKEVNLflqaqaasqENLEQFRENN--FASMKSQMElrikDLESELSKIKTSQEDFNKTELEKYK 1522
Cdd:TIGR02168  971 RRRL-KRLENKIKE-LGPVNL---------AAIEEYEELKerYDFLTAQKE----DLTEAKETLEEAIEEIDREARERFK 1035


                   ...
gi 2217276170 1523 QLY 1525
Cdd:TIGR02168 1036 DTF 1038
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 702-1464 2.72e-13

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 75.49  E-value: 2.72e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  702 ERLLELKKNHCELLTVKIKKMEDKVNVLQRELSE-TKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIRE 780
Cdd:TIGR02169  243 ERQLASLEEELEKLTEEISELEKRLEEIEQLLEElNKKIKDLGEEEQLRVKEKIGELEAEIASLERSIAEKERELEDAEE 322

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  781 QLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQL-SREQNARMLQDgiltNHLSKQKEIEMAQ 859
Cdd:TIGR02169  323 RLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELeEVDKEFAETRD----ELKDYREKLEKLK 398

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  860 KKMNSenshsheeekdLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEkkcfEDLKIVKEKNEDLQKTIKQNEETLTQTISQ 939
Cdd:TIGR02169  399 REINE-----------LKRELDRLQEELQRLSEELADLNAAIAGIE----AKINELEEEKEDKALEIKKQEWKLEQLAAD 463

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  940 yngrlsvltaenamlnskLENEKQSKERLEAEVESYHSRLaaaihdrdqsetSKRELELAFQRARDECSRLQDKMNFDVS 1019
Cdd:TIGR02169  464 ------------------LSKYEQELYDLKEEYDRVEKEL------------SKLQRELAEAEAQARASEERVRGGRAVE 513

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1020 NLKDNNeilSQQLFKTESKLNSLE-----------------------------IEFHHTRDALREKTLGLERVQKDLSQT 1070
Cdd:TIGR02169  514 EVLKAS---IQGVHGTVAQLGSVGeryataievaagnrlnnvvveddavakeaIELLKRRKAGRATFLPLNKMRDERRDL 590

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1071 QCQMK-----------EMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENML-LRQQLDD---AHNKADNKEKTVINIQD 1135
Cdd:TIGR02169  591 SILSEdgvigfavdlvEFDPKYEPAFKYVFGDTLVVEDIEAARRLMGKYRMVtLEGELFEksgAMTGGSRAPRGGILFSR 670

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1136 QFHAIVQKLQAESEKqsllLEERNKELISECNHLKER--QYQYENEKAEREVVVRQ-----LQQELADTLKKQSMSEASL 1208
Cdd:TIGR02169  671 SEPAELQRLRERLEG----LKRELSSLQSELRRIENRldELSQELSDASRKIGEIEkeieqLEQEEEKLKERLEELEEDL 746

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1209 EVTSRYRINLEDETQDLKKKLGQIRNQLQEAQdrhtEAVRCAEKMQDHK--QKLEKDNAKLKVTVKKQMDKIEELQKNLl 1286
Cdd:TIGR02169  747 SSLEQEIENVKSELKELEARIEELEEDLHKLE----EALNDLEARLSHSriPEIQAELSKLEEEVSRIEARLREIEQKL- 821

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1287 naNLSEDEKEQLKKLMELKQS----LECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYEngefSFHGDLKTSQFEMD 1362
Cdd:TIGR02169  822 --NRLTLEKEYLEKEIQELQEqridLKEQIKSIEKEIENLNGKKEELEEELEELEAALRDLE----SRLGDLKKERDELE 895

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1363 IQINKLKHKIDDLTAELETAGSKCLHLDTKNQILQEEL-----------------LSMKTVQKKCEKLQKNKKKLEQevI 1425
Cdd:TIGR02169  896 AQLRELERKIEELEAQIEKKRKRLSELKAKLEALEEELseiedpkgedeeipeeeLSLEDVQAELQRVEEEIRALEP--V 973

                          810       820       830       840
                   ....*....|....*....|....*....|....*....|
gi 2217276170 1426 NLRSHIERNMVELGQVK-QYKQEIEERARQEIAEKLKEVN 1464
Cdd:TIGR02169  974 NMLAIQEYEEVLKRLDElKEKRAKLEEERKAILERIEEYE 1013
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 9-220 1.60e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 71.56  E-value: 1.60e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170    9 GESPLgSFARRQRSSAGGGGEPGEGAYsqPGYHVRDRDlGKIHKAASAGNVAKVQQILLLRKNGLNDRDKMNRTALHLAC 88
Cdd:PHA02875    35 GISPI-KLAMKFRDSEAIKLLMKHGAI--PDVKYPDIE-SELHDAVEEGDVKAVEELLDLGKFADDVFYKDGMTPLHLAT 110

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170   89 ANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLY 168
Cdd:PHA02875   111 ILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDS 190

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2217276170  169 DANIEAKNKD-DLTPLLLAVSGKKQQMVEFLIKKKANVNAVDKLESSHQLISE 220
Cdd:PHA02875   191 GANIDYFGKNgCVAALCYAIENNKIDIVRLFIKRGADCNIMFMIEGEECTILD 243
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 54-210 8.45e-12

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 69.31  E-value: 8.45e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170   54 ASAGNVAKVQQILLLRKNGLNDRDKMNRTALHLACAN--GHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATI 131
Cdd:PHA03100    80 YNLTDVKEIVKLLLEYGANVNAPDNNGITPLLYAISKksNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIDLKIL 159

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  132 ------------------LLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQ 193
Cdd:PHA03100   160 kllidkgvdinaknrvnyLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKE 239

                          170
                   ....*....|....*..
gi 2217276170  194 MVEFLIKKKANVNAVDK 210
Cdd:PHA03100   240 IFKLLLNNGPSIKTIIE 256
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 691-1241 1.31e-11

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 69.82  E-value: 1.31e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  691 LLKIQDAALSCERLL-ELKKNHCELLTVKiKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRR 769
Cdd:pfam01576   14 LQKVKERQQKAESELkELEKKHQQLCEEK-NALQEQLQAETELCAEAEEMRARLAARKQELEEILHELESRLEEEEERSQ 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  770 NADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQR--------------QLSREQ 835
Cdd:pfam01576   93 QLQNEKKKMQQHIQDLEEQLDEEEAARQKLQLEKVTTEAKIKKLEEDILLLEDQNSKLSKerklleeriseftsNLAEEE 172

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  836 NARMLQDGILTNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEkkcfedlkiv 915
Cdd:pfam01576  173 EKAKSLSKLKNKHEAMISDLEERLKKEEKGRQELEKAKRKLEGESTDLQEQIAELQAQIAELRAQLAKKE---------- 242

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  916 keknEDLQKTIKQNEETLTQTiSQYNGRLSVLTAENAMLNSKLENEKQSKER-------LEAEVESYHSRLAAAIHDR-- 986
Cdd:pfam01576  243 ----EELQAALARLEEETAQK-NNALKKIRELEAQISELQEDLESERAARNKaekqrrdLGEELEALKTELEDTLDTTaa 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  987 DQSETSKRELELA-FQRARDECSRLQDKMNFDVSNLKDNN-EILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQ 1064
Cdd:pfam01576  318 QQELRSKREQEVTeLKKALEEETRSHEAQLQEMRQKHTQAlEELTEQLEQAKRNKANLEKAKQALESENAELQAELRTLQ 397

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1065 KDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAiVQKL 1144
Cdd:pfam01576  398 QAKQDSEHKRKKLEGQLQELQARLSESERQRAELAEKLSKLQSELESVSSLLNEAEGKNIKLSKDVSSLESQLQD-TQEL 476

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1145 QAESEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQ----SMSEASLEVTSRYRINLED 1220
Cdd:pfam01576  477 LQEETRQKLNLSTRLRQLEDERNSLQEQLEEEEEAKRNVERQLSTLQAQLSDMKKKLeedaGTLEALEEGKKRLQRELEA 556

                          570       580
                   ....*....|....*....|....*..
gi 2217276170 1221 ETQDLKKK------LGQIRNQLQEAQD 1241
Cdd:pfam01576  557 LTQQLEEKaaaydkLEKTKNRLQQELD 583
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 719-1500 1.66e-11

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 69.38  E-value: 1.66e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  719 IKKMEDKVNVLQRELSETKEIKsqlEHQKVEWERELCSLRFSLnQEEEKRRNAdtlyekiREQLRRKEEQYRKEVevKQQ 798
Cdd:pfam15921   80 LEEYSHQVKDLQRRLNESNELH---EKQKFYLRQSVIDLQTKL-QEMQMERDA-------MADIRRRESQSQEDL--RNQ 146

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  799 LELSLQTLEMElRTVKSNLnqvvqeRNDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQ-KKMNSENSHSHEEEKDL- 876
Cdd:pfam15921  147 LQNTVHELEAA-KCLKEDM------LEDSNTQIEQLRKMMLSHEGVLQEIRSILVDFEEASgKKIYEHDSMSTMHFRSLg 219

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  877 SHKNSMLQE---EIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNED-LQKTIKQNE---ETLTQTISQYNGRLSVLTA 949
Cdd:pfam15921  220 SAISKILREldtEISYLKGRIFPVEDQLEALKSESQNKIELLLQQHQDrIEQLISEHEveiTGLTEKASSARSQANSIQS 299

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  950 ENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHD-----RDQSETSKRELELA---FQRARDEcsrlQDKMNFDVSNL 1021
Cdd:pfam15921  300 QLEIIQEQARNQNSMYMRQLSDLESTVSQLRSELREakrmyEDKIEELEKQLVLAnseLTEARTE----RDQFSQESGNL 375

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1022 KDNNEILSQQLFKTESKLnSLE---------------IEFHHTRDALREKTLGLERVQKDLS--QTQCQmKEMEQKYQNE 1084
Cdd:pfam15921  376 DDQLQKLLADLHKREKEL-SLEkeqnkrlwdrdtgnsITIDHLRRELDDRNMEVQRLEALLKamKSECQ-GQMERQMAAI 453

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1085 QvkvnkyiGKQESVEERLS---QLQSENMLLRQQLDDAHNKA---DNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEER 1158
Cdd:pfam15921  454 Q-------GKNESLEKVSSltaQLESTKEMLRKVVEELTAKKmtlESSERTVSDLTASLQEKERAIEATNAEITKLRSRV 526

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1159 NKELiSECNHLKERQYQYENEKAErevvvrqlqqelADTLKKQsMSEASlEVTSRYRINLEDETQdLKKKLGQIRNQLQe 1238
Cdd:pfam15921  527 DLKL-QELQHLKNEGDHLRNVQTE------------CEALKLQ-MAEKD-KVIEILRQQIENMTQ-LVGQHGRTAGAMQ- 589

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1239 aqdrhTEAVRCAEKMQDHKQKLEKdnakLKVTVKKQMDKIEELQknllnANLSEDEKEQLKKLMELKQSLECnldqemKK 1318
Cdd:pfam15921  590 -----VEKAQLEKEINDRRLELQE----FKILKDKKDAKIRELE-----ARVSDLELEKVKLVNAGSERLRA------VK 649

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1319 NVELEREitGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMDIQINKLKHKIDDLTAELETAGS-------------- 1384
Cdd:pfam15921  650 DIKQERD--QLLNEVKTSRNELNSLSEDYEVLKRNFRNKSEEMETTTNKLKMQLKSAQSELEQTRNtlksmegsdghamk 727

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1385 --------------KCLHLDTKNQILQEellSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEE 1450
Cdd:pfam15921  728 vamgmqkqitakrgQIDALQSKIQFLEE---AMTNANKEKHFLKEEKNKLSQELSTVATEKNKMAGELEVLRSQERRLKE 804

                          810       820       830       840       850
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2217276170 1451 R-ARQEIAekLKEVNLflqaQAASQENLEQFRENNFASMKSQMELRIKDLE 1500
Cdd:pfam15921  805 KvANMEVA--LDKASL----QFAECQDIIQRQEQESVRLKLQHTLDVKELQ 849
PHA03095 PHA03095
ankyrin-like protein; Provisional
 94-212 1.99e-11

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 68.51  E-value: 1.99e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170   94 EVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATI---LLEHGADPNLADVHGNTALHYAVYNED-ISVATKLLLYD 169
Cdd:PHA03095    28 EEVRRLLAAGADVNFRGEYGKTPLHLYLHYSSEKVKDIvrlLLEAGADVNAPERCGFTPLHLYLYNATtLDVIKLLIKAG 107

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 2217276170  170 ANIEAKNKDDLTPLLLAVSGK--KQQMVEFLIKKKANVNAVDKLE 212
Cdd:PHA03095   108 ADVNAKDKVGRTPLHVYLSGFniNPKVIRLLLRKGADVNALDLYG 152
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1115-1553 3.23e-11

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 68.55  E-value: 3.23e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1115 QLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLL--LEERNKELISECNHL--KERQYQYENEKAEREV----- 1185
Cdd:PRK03918   156 GLDDYENAYKNLGEVIKEIKRRIERLEKFIKRTENIEELIkeKEKELEEVLREINEIssELPELREELEKLEKEVkelee 235

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1186 ---VVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIrNQLQEAQDRHTEAVRCAEKMQDHKQKLEK 1262
Cdd:PRK03918   236 lkeEIEELEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKEL-KELKEKAEEYIKLSEFYEEYLDELREIEK 314

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1263 DNAKLKV---TVKKQMDKIEELQKNLlnANLSEDEKEQLKKLMELKQSLEcNLDQEMKKNVELEREITGFKNL-LKMTRK 1338
Cdd:PRK03918   315 RLSRLEEeinGIEERIKELEEKEERL--EELKKKLKELEKRLEELEERHE-LYEEAKAKKEELERLKKRLTGLtPEKLEK 391

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1339 KLNEYENGEFSFHGDLKtsqfEMDIQINKLKHKIDDLTA---ELETAGSKC------LHLDTKNQILQEELLSMKTVQKK 1409
Cdd:PRK03918   392 ELEELEKAKEEIEEEIS----KITARIGELKKEIKELKKaieELKKAKGKCpvcgreLTEEHRKELLEEYTAELKRIEKE 467

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1410 CEKLQKNKKKLEQEVINLRSHI--ERNMVELGQVKQYKQEIEER----------ARQEIAEKLKEVNLFLQAQAASQENl 1477
Cdd:PRK03918   468 LKEIEEKERKLRKELRELEKVLkkESELIKLKELAEQLKELEEKlkkynleeleKKAEEYEKLKEKLIKLKGEIKSLKK- 546

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1478 EQFRENNFASMKSQMELRIKDLESELSKIKT--------SQEDFNKT--ELEKYKQLYLE----------ELKVRKSLSS 1537
Cdd:PRK03918   547 ELEKLEELKKKLAELEKKLDELEEELAELLKeleelgfeSVEELEERlkELEPFYNEYLElkdaekelerEEKELKKLEE 626

                          490
                   ....*....|....*.
gi 2217276170 1538 KLTKTNERLAEVNTKL 1553
Cdd:PRK03918   627 ELDKAFEELAETEKRL 642
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 706-1238 6.54e-11

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 67.65  E-value: 6.54e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  706 ELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRK 785
Cdd:COG1196    221 ELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARL 300

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  786 EEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQKKMNSE 865
Cdd:COG1196    301 EQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEE 380

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  866 -----NSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKcfEDLKIVKEKNEDLQKTIKQNEETLTQTISQY 940
Cdd:COG1196    381 leelaEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELE--EALAELEEEEEEEEEALEEAAEEEAELEEEE 458

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  941 NGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDEC------------- 1007
Cdd:COG1196    459 EALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAvavligveaayea 538

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1008 -------SRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEfhhtRDALREKTLGLERVQKDLSQTQCQMKEMEQK 1080
Cdd:COG1196    539 aleaalaAALQNIVVEDDEVAAAAIEYLKAAKAGRATFLPLDKIR----ARAALAAALARGAIGAAVDLVASDLREADAR 614

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1081 Y---QNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQS---LL 1154
Cdd:COG1196    615 YyvlGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAeeeLE 694

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1155 LEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRN 1234
Cdd:COG1196    695 LEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELERLER 774


                   ....
gi 2217276170 1235 QLQE 1238
Cdd:COG1196    775 EIEA 778
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 893-1522 1.04e-10

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 66.58  E-value: 1.04e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  893 EIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQ------KTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKE 966
Cdd:TIGR04523   41 KLKTIKNELKNKEKELKNLDKNLNKDEEKINnsnnkiKILEQQIKDLNDKLKKNKDKINKLNSDLSKINSEIKNDKEQKN 120

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  967 RLEAEVESyhsrlaaaihdrdqsetSKRELElafqrardECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEF 1046
Cdd:TIGR04523  121 KLEVELNK-----------------LEKQKK--------ENKKNIDKFLTEIKKKEKELEKLNNKYNDLKKQKEELENEL 175

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1047 HHTRDALREKtlglervQKDLSQTQCQMKEMEQKYQNEQvkvnKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNK 1126
Cdd:TIGR04523  176 NLLEKEKLNI-------QKNIDKIKNKLLKLELLLSNLK----KKIQKNKSLESQISELKKQNNQLKDNIEKKQQEINEK 244

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1127 EKTVINIQDQFHAIVQKLQAESEKqsllLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQ-SMSE 1205
Cdd:TIGR04523  245 TTEISNTQTQLNQLKDEQNKIKKQ----LSEKQKELEQNNKKIKELEKQLNQLKSEISDLNNQKEQDWNKELKSElKNQE 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1206 ASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNL 1285
Cdd:TIGR04523  321 KKLEEIQNQISQNNKIISQLNEQISQLKKELTNSESENSEKQRELEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKI 400

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1286 LNANLSEDEKE-QLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENgefsFHGDLKTSQFEMDIQ 1364
Cdd:TIGR04523  401 QNQEKLNQQKDeQIKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVKELIIKNLDN----TRESLETQLKVLSRS 476

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1365 INKLKHKIDDLTAELETAGSKCLHLDTKNQILQEELLSMKTVQK----KCEKLQKNKKKLEQEVINLRSHIERNMVELgq 1440
Cdd:TIGR04523  477 INKIKQNLEQKQKELKSKEKELKKLNEEKKELEEKVKDLTKKISslkeKIEKLESEKKEKESKISDLEDELNKDDFEL-- 554

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1441 vKQYKQEIEERARQEIAEKLKEVNLFLQAQAASQENLEQFRENNFASMKSQMELRIKDLESELSKIKTSQEDFNKTELEK 1520
Cdd:TIGR04523  555 -KKENLEKEIDEKNKEIEELKQTQKSLKKKQEEKQELIDQKEKEKKDLIKEIEEKEKKISSLEKELEKAKKENEKLSSII 633


                   ..
gi 2217276170 1521 YK 1522
Cdd:TIGR04523  634 KN 635
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 75-209 1.13e-10

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 66.06  E-value: 1.13e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170   75 DRDKMNrTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPNLADVHGNTALHYAV 154
Cdd:PHA02878   164 DRHKGN-TALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISV 242

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2217276170  155 -YNEDISVATKLLLYDANIEAKNK-DDLTPLLLAVsgKKQQMVEFLIKKKANVNAVD 209
Cdd:PHA02878   243 gYCKDYDILKLLLEHGVDVNAKSYiLGLTALHSSI--KSERKLKLLLEYGADINSLN 297
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 729-1423 1.22e-10

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 66.53  E-value: 1.22e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  729 LQRELSETKEIKSQLEhqKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLrrKEEQYRKEVEVKQQLELSLQTLEM 808
Cdd:TIGR00618  158 LKAKSKEKKELLMNLF--PLDQYTQLALMEFAKKKSLHGKAELLTLRSQLLTLC--TPCMPDTYHERKQVLEKELKHLRE 233

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  809 ELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGI------LTNHLSKQKEIEMA------------------------ 858
Cdd:TIGR00618  234 ALQQTQQSHAYLTQKREAQEEQLKKQQLLKQLRARIeelraqEAVLEETQERINRArkaaplaahikavtqieqqaqrih 313

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  859 ---QKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQ 935
Cdd:TIGR00618  314 telQSKMRSRAKLLMKRAAHVKQQSSIEEQRRLLQTLHSQEIHIRDAHEVATSIREISCQQHTLTQHIHTLQQQKTTLTQ 393

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  936 TISQYNGRLSVLTAENAM---LNSKLENEKQSKERLEAEVE---SYHSRLAAAIHDRDQSET-SKRELELAFQRARDECS 1008
Cdd:TIGR00618  394 KLQSLCKELDILQREQATidtRTSAFRDLQGQLAHAKKQQElqqRYAELCAAAITCTAQCEKlEKIHLQESAQSLKEREQ 473

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1009 RLQDKMNF--DVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREktlglervqkdLSQTQCQMKEMEQKYQNEQV 1086
Cdd:TIGR00618  474 QLQTKEQIhlQETRKKAVVLARLLELQEEPCPLCGSCIHPNPARQDIDN-----------PGPLTRRMQRGEQTYAQLET 542

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1087 KVNKYIGKQESVEERLSQLQSENMLLRQQLdDAHNKADNKEKTVINIQDQFHAIVQKL---QAESEKQSLLLEERNKELI 1163
Cdd:TIGR00618  543 SEEDVYHQLTSERKQRASLKEQMQEIQQSF-SILTQCDNRSKEDIPNLQNITVRLQDLtekLSEAEDMLACEQHALLRKL 621

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1164 SECNHlKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTS------RYRINLEDETQDLKKKLGQIRNQLQ 1237
Cdd:TIGR00618  622 QPEQD-LQDVRLHLQQCSQELALKLTALHALQLTLTQERVREHALSIRVlpkellASRQLALQKMQSEKEQLTYWKEMLA 700

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1238 EAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLnanlsEDEKEQLKKLMELKQslecnldqemK 1317
Cdd:TIGR00618  701 QCQTLLRELETHIEEYDREFNEIENASSSLGSDLAAREDALNQSLKELM-----HQARTVLKARTEAHF----------N 765

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1318 KNVELEREITGFKNLLKMTRKKLNEYENGEFSFHgdlKTSQFEMDIQiNKLKHKIDDLTAELETAGSKCLHLDTKNQILQ 1397
Cdd:TIGR00618  766 NNEEVTAALQTGAELSHLAAEIQFFNRLREEDTH---LLKTLEAEIG-QEIPSDEDILNLQCETLVQEEEQFLSRLEEKS 841

                          730       740
                   ....*....|....*....|....*.
gi 2217276170 1398 EELLSMKTVQKKCEKLQKNKKKLEQE 1423
Cdd:TIGR00618  842 ATLGEITHQLLKYEECSKQLAQLTQE 867
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 66-280 1.81e-10

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 66.04  E-value: 1.81e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170   66 LLLRKNGLNDRDKMNRTALHLAcANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPNLADVH 145
Cdd:PLN03192   512 LLGDNGGEHDDPNMASNLLTVA-STGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDAN 590

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  146 GNTAL-------HYAVYN------------------------EDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQM 194
Cdd:PLN03192   591 GNTALwnaisakHHKIFRilyhfasisdphaagdllctaakrNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDM 670

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  195 VEFLIKKKANVNAVDKLES-SHQLISEYKEERIPKHSSQNSNSVDESSEDSLSRLSGKPGVDDSwpTSDDEdlnfdtKNV 273
Cdd:PLN03192   671 VRLLIMNGADVDKANTDDDfSPTELRELLQKRELGHSITIVDSVPADEPDLGRDGGSRPGRLQG--TSSDN------QCR 742


                   ....*..
gi 2217276170  274 PKPSLAK 280
Cdd:PLN03192   743 PRVSIYK 749
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 780-1541 2.00e-10

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 65.86  E-value: 2.00e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  780 EQLRRKEEQYRKEVEvkqQLELSLQTLEMELRTVKSNLNQVVQERNDAQR--QLSREqnarmLQDGILTNHLsKQKEIEM 857
Cdd:TIGR02169  166 AEFDRKKEKALEELE---EVEENIERLDLIIDEKRQQLERLRREREKAERyqALLKE-----KREYEGYELL-KEKEALE 236

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  858 AQKKmnsenshshEEEKDLSHknsmLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTI 937
Cdd:TIGR02169  237 RQKE---------AIERQLAS----LEEELEKLTEEISELEKRLEEIEQLLEELNKKIKDLGEEEQLRVKEKIGELEAEI 303

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  938 SQ-------YNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAI----HDRDQSETSKRELE---LAFQRA 1003
Cdd:TIGR02169  304 ASlersiaeKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTeeyaELKEELEDLRAELEevdKEFAET 383

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1004 RDECSRLQDKM----------NFDVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQ 1073
Cdd:TIGR02169  384 RDELKDYREKLeklkreinelKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQEWKLEQLAAD 463

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1074 MKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHN-----KADN-------------KEKTVINIQ- 1134
Cdd:TIGR02169  464 LSKYEQELYDLKEEYDRVEKELSKLQRELAEAEAQARASEERVRGGRAveevlKASIqgvhgtvaqlgsvGERYATAIEv 543

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1135 ---DQFHAIVQKLQAESEKQSLLLEERN------------------KELISECNHLK--------ERQYQ---------- 1175
Cdd:TIGR02169  544 aagNRLNNVVVEDDAVAKEAIELLKRRKagratflplnkmrderrdLSILSEDGVIGfavdlvefDPKYEpafkyvfgdt 623

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1176 --YENEKAEREVVVR----QLQQELADtlKKQSMS----------------EASLEVTSRYRINLEDETQDLKKKLGQIR 1233
Cdd:TIGR02169  624 lvVEDIEAARRLMGKyrmvTLEGELFE--KSGAMTggsraprggilfsrsePAELQRLRERLEGLKRELSSLQSELRRIE 701

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1234 NQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLlnanlsEDEKEQLKKLMELKQSLECNLD 1313
Cdd:TIGR02169  702 NRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEI------ENVKSELKELEARIEELEEDLH 775

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1314 QEMKKNVELEREITGFKnllkmTRKKLNEYEngefsfhgDLKTSQFEMDIQINKLKHKIDDLTAELETAGSKCLHL---- 1389
Cdd:TIGR02169  776 KLEEALNDLEARLSHSR-----IPEIQAELS--------KLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELqeqr 842

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1390 -DTKNQI--LQEELLSMKT----VQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERarqeiAEKLKE 1462
Cdd:TIGR02169  843 iDLKEQIksIEKEIENLNGkkeeLEEELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQ-----IEKKRK 917

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1463 VNLFLQAQAASQENLEQFRENNFASMKS---------QMELRIKDLESELSKIktsqEDFNKTELEKYKqlylEELKVRK 1533
Cdd:TIGR02169  918 RLSELKAKLEALEEELSEIEDPKGEDEEipeeelsleDVQAELQRVEEEIRAL----EPVNMLAIQEYE----EVLKRLD 989


                   ....*...
gi 2217276170 1534 SLSSKLTK 1541
Cdd:TIGR02169  990 ELKEKRAK 997
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 903-1563 2.03e-10

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 65.85  E-value: 2.03e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  903 EKEKKCFEDLKIVKEKNEDLQKTI--------KQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVES 974
Cdd:TIGR02168  206 ERQAEKAERYKELKAELRELELALlvlrleelREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEE 285

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  975 YHSRLAAAihdrdQSETSKRELELAFQRARDEcsrlqdkmnfdvsNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALR 1054
Cdd:TIGR02168  286 LQKELYAL-----ANEISRLEQQKQILRERLA-------------NLERQLEELEAQLEELESKLDELAEELAELEEKLE 347

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1055 EKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAhnkADNKEKTVINIQ 1134
Cdd:TIGR02168  348 ELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERL---EDRRERLQQEIE 424

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1135 DQfhaivqkLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRY 1214
Cdd:TIGR02168  425 EL-------LKKLEEAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERL 497

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1215 RINLEDETQDLKKKLgQIRNQLQEAQDRHTEAVRCAEK--------MQDHKQKLE--------------KDNAKLKVTV- 1271
Cdd:TIGR02168  498 QENLEGFSEGVKALL-KNQSGLSGILGVLSELISVDEGyeaaieaaLGGRLQAVVvenlnaakkaiaflKQNELGRVTFl 576

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1272 -----------KKQMDKIEELQKNLLNANLSEDEKEQLKKLME-----------LKQSLEC------------------- 1310
Cdd:TIGR02168  577 pldsikgteiqGNDREILKNIEGFLGVAKDLVKFDPKLRKALSyllggvlvvddLDNALELakklrpgyrivtldgdlvr 656

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1311 -----------------NLDQEMKKNV----ELEREITGFKNLLKMTRKKLNEYENGEfsfhGDLKTSQFEMDIQINKLK 1369
Cdd:TIGR02168  657 pggvitggsaktnssilERRREIEELEekieELEEKIAELEKALAELRKELEELEEEL----EQLRKELEELSRQISALR 732

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1370 HKIDDLTAELETAGSKCLHLDTKNQILQEEllsMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIE 1449
Cdd:TIGR02168  733 KDLARLEAEVEQLEERIAQLSKELTELEAE---IEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELR 809

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1450 ERARQ---EIAEKLKEVNLFLQAQAASQENLEQFRENnfasmKSQMELRIKDLESELSKIKTSQEDFNKtELEKYKQLYL 1526
Cdd:TIGR02168  810 AELTLlneEAANLRERLESLERRIAATERRLEDLEEQ-----IEELSEDIESLAAEIEELEELIEELES-ELEALLNERA 883

                          730       740       750
                   ....*....|....*....|....*....|....*..
gi 2217276170 1527 EELKVRKSLSSKLTKTNERLAEVNTKLLVEKQQSRSL 1563
Cdd:TIGR02168  884 SLEEALALLRSELEELSEELRELESKRSELRRELEEL 920
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 807-1553 4.29e-10

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 64.86  E-value: 4.29e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  807 EMELRTVKSNLNQVVQER--NDAQRQLSREQNARMLQDgiltnhlskqkeIEMAQKKMNsenshsheeekdLSHKNSMLQ 884
Cdd:pfam12128  192 EGKFRDVKSMIVAILEDDgvVPPKSRLNRQQVEHWIRD------------IQAIAGIMK------------IRPEFTKLQ 247

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  885 EEIAMLR---LEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLEN- 960
Cdd:pfam12128  248 QEFNTLEsaeLRLSHLHFGYKSDETLIASRQEERQETSAELNQLLRTLDDQWKEKRDELNGELSAADAAVAKDRSELEAl 327

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  961 EKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARD---ECSRLQDKM----NFDVSNLKDN----NEILS 1029
Cdd:pfam12128  328 EDQHGAFLDADIETAAADQEQLPSWQSELENLEERLKALTGKHQDvtaKYNRRRSKIkeqnNRDIAGIKDKlakiREARD 407

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1030 QQLFKTESKLNSLEIEFHHTRDA----LREKTLG----LERVQKDLSQTQCQMKEMEQKYQNeQVKVNKYIGKQESVEER 1101
Cdd:pfam12128  408 RQLAVAEDDLQALESELREQLEAgkleFNEEEYRlksrLGELKLRLNQATATPELLLQLENF-DERIERAREEQEAANAE 486

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1102 LSQLQSEnmllRQQLDDAHNKADNKEKtviniqdQFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKA 1181
Cdd:pfam12128  487 VERLQSE----LRQARKRRDQASEALR-------QASRRLEERQSALDELELQLFPQAGTLLHFLRKEAPDWEQSIGKVI 555

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1182 EREVVVR-QLQQELADTLKKQSMSEASLEVTSRyRINLED---ETQDLKKKLGQIRNQLQEAQDRHTEAvrcAEKMQDHK 1257
Cdd:pfam12128  556 SPELLHRtDLDPEVWDGSVGGELNLYGVKLDLK-RIDVPEwaaSEEELRERLDKAEEALQSAREKQAAA---EEQLVQAN 631

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1258 QKLekDNAKLKVTVKKQMDKIEELQKNLLNanlseDEKEQLKklMELKQSLECNLDQEMKKNVELEREitgfKNLLKMTR 1337
Cdd:pfam12128  632 GEL--EKASREETFARTALKNARLDLRRLF-----DEKQSEK--DKKNKALAERKDSANERLNSLEAQ----LKQLDKKH 698

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1338 KKLNEYENGEFSFHGDLKtsQFEMDIQINKLKHKIDDLTAELETAGSKclhLDTKNQILQEEllsMKTVQKKCEKLQKNK 1417
Cdd:pfam12128  699 QAWLEEQKEQKREARTEK--QAYWQVVEGALDAQLALLKAAIAARRSG---AKAELKALETW---YKRDLASLGVDPDVI 770

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1418 KKLEQEVINLRSHIERNMVELGQVKQYKQEIEER---ARQEIAEKLKEVN---LFLQAQAASQE-----NLEQFRENNFA 1486
Cdd:pfam12128  771 AKLKREIRTLERKIERIAVRRQEVLRYFDWYQETwlqRRPRLATQLSNIEraiSELQQQLARLIadtklRRAKLEMERKA 850

                          730       740       750       760       770       780       790
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217276170 1487 SMKSQMEL--RIKDLESELSKIKTSQEDFNKTELE---KYKQLYLEELK-VRKSLSSKLTKTNERLAEVNTKL 1553
Cdd:pfam12128  851 SEKQQVRLseNLRGLRCEMSKLATLKEDANSEQAQgsiGERLAQLEDLKlKRDYLSESVKKYVEHFKNVIADH 923
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1036-1344 5.62e-10

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 64.57  E-value: 5.62e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1036 ESKLNSLEIEfhhTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQ 1115
Cdd:COG1196    199 ERQLEPLERQ---AEKAERYRELKEELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLE 275

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1116 LDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSlLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELA 1195
Cdd:COG1196    276 LEELELELEEAQAEEYELLAELARLEQDIARLEERRR-ELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELE 354

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1196 DTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQM 1275
Cdd:COG1196    355 EAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELE 434

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1276 DKIEELQKNLLNANLSEDEKEQ-LKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYE 1344
Cdd:COG1196    435 EEEEEEEEALEEAAEEEAELEEeEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYE 504
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 39-214 9.31e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 63.54  E-value: 9.31e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170   39 GYHVRDRDLGK---IHKAASAGNVAKVQQILLLRKNGLNDRDKMNRTALHLACANGH-PEVVTLLVDRKCQLNVCDNENR 114
Cdd:PHA02876   263 GFSVNSIDDCKntpLHHASQAPSLSRLVPKLLERGADVNAKNIKGETPLYLMAKNGYdTENIRTLIMLGADVNAADRLYI 342

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  115 TALMKAVQCQEEKCATI-LLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQ 193
Cdd:PHA02876   343 TPLHQASTLDRNKDIVItLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFALCGTNPY 422

                          170       180
                   ....*....|....*....|..
gi 2217276170  194 M-VEFLIKKKANVNAVDKLESS 214
Cdd:PHA02876   423 MsVKTLIDRGANVNSKNKDLST 444
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 125-210 1.14e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 62.59  E-value: 1.14e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  125 EEKCATILLEHGADPNLADVH-GNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKA 203
Cdd:PHA02878   146 EAEITKLLLSYGADINMKDRHkGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGA 225


                   ....*..
gi 2217276170  204 NVNAVDK 210
Cdd:PHA02878   226 STDARDK 232
PHA03095 PHA03095
ankyrin-like protein; Provisional
 55-179 1.40e-09

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 62.35  E-value: 1.40e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170   55 SAGNVAKVqqILLLRKNG--LNDRDKMNRTALHL-ACANGHPEVVTLLVDRKCQLNVCDNENRTALMK--AVQCQEEKCA 129
Cdd:PHA03095    58 SSEKVKDI--VRLLLEAGadVNAPERCGFTPLHLyLYNATTLDVIKLLIKAGADVNAKDKVGRTPLHVylSGFNINPKVI 135

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 2217276170  130 TILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDD 179
Cdd:PHA03095   136 RLLLRKGADVNALDLYGMTPLAVLLKSRNANVELLRLLIDAGADVYAVDD 185
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 765-1560 1.54e-09

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 63.07  E-value: 1.54e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  765 EEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQL-------------ELSLQTLEMELRTVKSNLNQVVQERNDaqrQL 831
Cdd:pfam02463  166 RLKRKKKEALKKLIEETENLAELIIDLEELKLQELklkeqakkaleyyQLKEKLELEEEYLLYLDYLKLNEERID---LL 242

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  832 SREQNARMLQDGILTNHLSKQKEIEMAQKKMNSENShshEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFED 911
Cdd:pfam02463  243 QELLRDEQEEIESSKQEIEKEEEKLAQVLKENKEEE---KEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKES 319

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  912 LKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIhdRDQSET 991
Cdd:pfam02463  320 EKEKKKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAK--LKEEEL 397

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  992 SKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALR-EKTLGLERVQKDLSQT 1070
Cdd:pfam02463  398 ELKSEEEKEAQLLLELARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLlKDELELKKSEDLLKET 477

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1071 QCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAhnKADNKEKTVINIQDQFHAIVQKLQAESEK 1150
Cdd:pfam02463  478 QLVKLQEQLELLLSRQKLEERSQKESKARSGLKVLLALIKDGVGGRIIS--AHGRLGDLGVAVENYKVAISTAVIVEVSA 555

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1151 QSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDET--QDLKKK 1228
Cdd:pfam02463  556 TADEVEERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAVLEIDPILNLAQLDKATLEADEDDKRAKVVEGilKDTELT 635

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1229 LGQIRNQLQEAQDRHTEAVRCAEKM-QDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDEKEQLKKLMELKQS 1307
Cdd:pfam02463  636 KLKESAKAKESGLRKGVSLEEGLAEkSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEIKKKEQREKEELKKL 715

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1308 LECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMDIQINKLKHKIDDLTAELETAGSKcl 1387
Cdd:pfam02463  716 KLEAEELLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKELAEEREKTEKLKVEEEKE-- 793

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1388 hldtKNQILQEELLSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERARQEIAEKLKEVNLFL 1467
Cdd:pfam02463  794 ----EKLKAQEEELRALEEELKEEAELLEEEQLLIEQEEKIKEEELEELALELKEEQKLEKLAEEELERLEEEITKEELL 869

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1468 QAQAASQENLEQFRENNFASMKSQMELRIKDLESELSKIKTSQEDFNKTELEKYKQLYLEELKVRKSL--SSKLTKTNER 1545
Cdd:pfam02463  870 QELLLKEEELEEQKLKDELESKEEKEKEEKKELEEESQKLNLLEEKENEIEERIKEEAEILLKYEEEPeeLLLEEADEKE 949

                          810
                   ....*....|....*
gi 2217276170 1546 LAEVNTKLLVEKQQS 1560
Cdd:pfam02463  950 KEENNKEEEEERNKR 964
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 765-1380 2.24e-09

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 62.65  E-value: 2.24e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  765 EEKRRNADTL---------YEKIREQLRRKEEQYRkeVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQ 835
Cdd:COG1196    196 GELERQLEPLerqaekaerYRELKEELKELEAELL--LLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELR 273

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  836 NArmlqdgiltnHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHknsmLQEEIAMLRLEIDTIKNQNQEKEkkcfedlkiv 915
Cdd:COG1196    274 LE----------LEELELELEEAQAEEYELLAELARLEQDIAR----LEERRRELEERLEELEEELAELE---------- 329

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  916 kEKNEDLQKTIKQNEETLTQtisqyngrlsvltaenamlnskLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRE 995
Cdd:COG1196    330 -EELEELEEELEELEEELEE----------------------AEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAE 386

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  996 LELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMK 1075
Cdd:COG1196    387 ELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLA 466

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1076 EMEQKYQNEQVKVnkyigkQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLL 1155
Cdd:COG1196    467 ELLEEAALLEAAL------AELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAAL 540

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1156 EERNKELIsecnhlkeRQYQYENEKAEREVVVRQLQQELA-------DTLKKQSMSEASLE--VTSRYRINLEDETQDLK 1226
Cdd:COG1196    541 EAALAAAL--------QNIVVEDDEVAAAAIEYLKAAKAGratflplDKIRARAALAAALArgAIGAAVDLVASDLREAD 612

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1227 KKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLE------------KDNAKLKVTVKKQMDKIEELQKNLLNANLSEDE 1294
Cdd:COG1196    613 ARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLRevtlegeggsagGSLTGGSRRELLAALLEAEAELEELAERLAEEE 692

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1295 KEQLKKLMELKQSLEcNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMDIQINKLKHKIDD 1374
Cdd:COG1196    693 LELEEALLAEEEEER-ELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELER 771


                   ....*.
gi 2217276170 1375 LTAELE 1380
Cdd:COG1196    772 LEREIE 777
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 50-214 3.35e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 61.22  E-value: 3.35e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170   50 IHKAASAGNVAKVQQILllrKNG--LNDRDKMNRTALHLACANGH-----PEVVTLLVDRKCQLNVCDNENRTALMKAVQ 122
Cdd:PHA03100    39 LYLAKEARNIDVVKILL---DNGadINSSTKNNSTPLHYLSNIKYnltdvKEIVKLLLEYGANVNAPDNNGITPLLYAIS 115

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  123 CQEEKCATI--LLEHGADPNLADVHGNTALHYAV---------------YNEDISVATK---LLLYDANIEAKNKDDLTP 182
Cdd:PHA03100   116 KKSNSYSIVeyLLDNGANVNIKNSDGENLLHLYLesnkidlkilkllidKGVDINAKNRvnyLLSYGVPINIKDVYGFTP 195

                          170       180       190
                   ....*....|....*....|....*....|..
gi 2217276170  183 LLLAVSGKKQQMVEFLIKKKANVNAVDKLESS 214
Cdd:PHA03100   196 LHYAVYNNNPEFVKYLLDLGANPNLVNKYGDT 227
PHA03095 PHA03095
ankyrin-like protein; Provisional
 50-209 3.86e-09

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 61.19  E-value: 3.86e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170   50 IHKAASAGNVAKVQQiLLLRKNG-LNDRDKMNRTALH--LACANGHPEVVTLLVDRKCQLNVCDNENRT---ALMKAVQC 123
Cdd:PHA03095    87 LHLYLYNATTLDVIK-LLIKAGAdVNAKDKVGRTPLHvyLSGFNINPKVIRLLLRKGADVNALDLYGMTplaVLLKSRNA 165

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  124 QEE----------------------------------KCATILLEHGADPNLADVHGNTALHYAVYNEDI--SVATKLLL 167
Cdd:PHA03095   166 NVEllrllidagadvyavddrfrsllhhhlqsfkpraRIVRELIRAGCDPAATDMLGNTPLHSMATGSSCkrSLVLPLLI 245

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 2217276170  168 YDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKANVNAVD 209
Cdd:PHA03095   246 AGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVS 287
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 50-211 3.90e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 61.62  E-value: 3.90e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170   50 IHKAASAGNvAKVQQILLLRKNGLNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNvcdnENRTALMKAVQCQEEKCA 129
Cdd:PHA02876   182 IHYAAERGN-AKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSNIN----KNDLSLLKAIRNEDLETS 256

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  130 TILLEHGADPNLADVHGNTALHYAVYNEDIS-VATKLLLYDANIEAKNKDDLTPL-LLAVSGKKQQMVEFLIKKKANVNA 207
Cdd:PHA02876   257 LLLYDAGFSVNSIDDCKNTPLHHASQAPSLSrLVPKLLERGADVNAKNIKGETPLyLMAKNGYDTENIRTLIMLGADVNA 336


                   ....
gi 2217276170  208 VDKL 211
Cdd:PHA02876   337 ADRL 340
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 707-1143 4.68e-09

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 61.19  E-value: 4.68e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  707 LKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKE 786
Cdd:TIGR04523  194 NKLLKLELLLSNLKKKIQKNKSLESQISELKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQNKIKKQLSEKQ 273

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  787 EQYRKEVEVKQQLELSLQTLEMEL------------RTVKSNLNQVVQERNDAQRQLSR-EQNARMLQDGIL-------- 845
Cdd:TIGR04523  274 KELEQNNKKIKELEKQLNQLKSEIsdlnnqkeqdwnKELKSELKNQEKKLEEIQNQISQnNKIISQLNEQISqlkkeltn 353

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  846 --TNHLSKQKEIEMAQKKMNSENshshEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKcfedLKIVKEKNEDLQ 923
Cdd:TIGR04523  354 seSENSEKQRELEEKQNEIEKLK----KENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQ----IKKLQQEKELLE 425

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  924 KTIKQneetLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSE---TSKRELELAF 1000
Cdd:TIGR04523  426 KEIER----LKETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESLETQLKVLSRSINKIKQNLEQKQkelKSKEKELKKL 501

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1001 QRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLE-----IEFHHTRDALREKTLG-------LERVQKDLS 1068
Cdd:TIGR04523  502 NEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEKESKISDLEdelnkDDFELKKENLEKEIDEknkeieeLKQTQKSLK 581

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2217276170 1069 QTQCQMKEMEQKYQNEQVKVNK----YIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQK 1143
Cdd:TIGR04523  582 KKQEEKQELIDQKEKEKKDLIKeieeKEKKISSLEKELEKAKKENEKLSSIIKNIKSKKNKLKQEVKQIKETIKEIRNK 660
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 783-1170 5.02e-09

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 61.24  E-value: 5.02e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  783 RRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQKKM 862
Cdd:TIGR02169  670 RSEPAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSL 749

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  863 NSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEkekkcfEDLKIVKEKNEDLQKTIKQNEETLTQTisqyNG 942
Cdd:TIGR02169  750 EQEIENVKSELKELEARIEELEEDLHKLEEALNDLEARLSH------SRIPEIQAELSKLEEEVSRIEARLREI----EQ 819

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  943 RLSVLTAENAMlnskLENEKQSKERLEAEVESYHSRLAAAIHDrdqSETSKRELELAFQRARDECSRLQDKMnfdvSNLK 1022
Cdd:TIGR02169  820 KLNRLTLEKEY----LEKEIQELQEQRIDLKEQIKSIEKEIEN---LNGKKEELEEELEELEAALRDLESRL----GDLK 888

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1023 DNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQkYQNEQVKVNKYIGKQESVEERL 1102
Cdd:TIGR02169  889 KERDELEAQLRELERKIEELEAQIEKKRKRLSELKAKLEALEEELSEIEDPKGEDEE-IPEEELSLEDVQAELQRVEEEI 967

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1103 SQLQSENMLLRQQLDDAhnkadnkektviniqdqfhaiVQKLQAESEKQSLLLEERN--KELISECNHLK 1170
Cdd:TIGR02169  968 RALEPVNMLAIQEYEEV---------------------LKRLDELKEKRAKLEEERKaiLERIEEYEKKK 1016
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 678-1241 7.26e-09

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 60.90  E-value: 7.26e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  678 IEQLGMECKDSVSLLKIQDAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKS----QLEHQKVEWERE 753
Cdd:pfam15921  278 VEITGLTEKASSARSQANSIQSQLEIIQEQARNQNSMYMRQLSDLESTVSQLRSELREAKRMYEdkieELEKQLVLANSE 357

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  754 LCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQL---------------------ELSLQTLEMELRT 812
Cdd:pfam15921  358 LTEARTERDQFSQESGNLDDQLQKLLADLHKREKELSLEKEQNKRLwdrdtgnsitidhlrrelddrNMEVQRLEALLKA 437

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  813 VKSNlnqvVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEI------EMAQKKMNSENShsheeEKDLSHKNSMLQE- 885
Cdd:pfam15921  438 MKSE----CQGQMERQMAAIQGKNESLEKVSSLTAQLESTKEMlrkvveELTAKKMTLESS-----ERTVSDLTASLQEk 508

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  886 ---------EIAMLRLEIDT-------IKNQN---QEKEKKCfEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSV 946
Cdd:pfam15921  509 eraieatnaEITKLRSRVDLklqelqhLKNEGdhlRNVQTEC-EALKLQMAEKDKVIEILRQQIENMTQLVGQHGRTAGA 587

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  947 LTAENAMLNSK-------------LENEKQSKER-LEAEV---ESYHSRLAAAIHDRDQS----ETSKRELELAFQRARD 1005
Cdd:pfam15921  588 MQVEKAQLEKEindrrlelqefkiLKDKKDAKIReLEARVsdlELEKVKLVNAGSERLRAvkdiKQERDQLLNEVKTSRN 667

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1006 ECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALR----------------EKTLGLERVQKDLSQ 1069
Cdd:pfam15921  668 ELNSLSEDYEVLKRNFRNKSEEMETTTNKLKMQLKSAQSELEQTRNTLKsmegsdghamkvamgmQKQITAKRGQIDALQ 747

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1070 TQCQMKEMEQKYQNEQV-----KVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQF---HAIV 1141
Cdd:pfam15921  748 SKIQFLEEAMTNANKEKhflkeEKNKLSQELSTVATEKNKMAGELEVLRSQERRLKEKVANMEVALDKASLQFaecQDII 827

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1142 QKLQAESEKQSLLLEERNKEL----ISECNHLKERQYQYENEKAEREVVVRQlqQELADTLKKQSMSEASLEvtsryrin 1217
Cdd:pfam15921  828 QRQEQESVRLKLQHTLDVKELqgpgYTSNSSMKPRLLQPASFTRTHSNVPSS--QSTASFLSHHSRKTNALK-------- 897

                          650       660
                   ....*....|....*....|....
gi 2217276170 1218 lEDETQDLKKKLGQIRNQLQEAQD 1241
Cdd:pfam15921  898 -EDPTRDLKQLLQELRSVINEEPT 920
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 129-282 9.92e-09

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 60.30  E-value: 9.92e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  129 ATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVeflikkkanvnav 208
Cdd:PTZ00322    98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVV------------- 164

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217276170  209 dklesshQLISEYKEEripkHSSQNSNSVDESsedslsrLSGKPGVDDSWPTSDDEDlnfDTKNVPKPSLAKLM 282
Cdd:PTZ00322   165 -------QLLSRHSQC----HFELGANAKPDS-------FTGKPPSLEDSPISSHHP---DFSAVPQPMMGSLI 217
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 718-1541 1.28e-08

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 60.06  E-value: 1.28e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  718 KIKKMEDKVNVLQRELSETKEIKSQLEHQKVEwerELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEvkq 797
Cdd:TIGR00606  263 KIMKLDNEIKALKSRKKQMEKDNSELELKMEK---VFQGTDEQLNDLYHNHQRTVREKERELVDCQRELEKLNKERR--- 336

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  798 qlELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEI----EMAQKKMNSENSHSHEEE 873
Cdd:TIGR00606  337 --LLNQEKTELLVEQGRLQLQADRHQEHIRARDSLIQSLATRLELDGFERGPFSERQIknfhTLVIERQEDEAKTAAQLC 414

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  874 KDLSHKNSMLQEEIAMLRLEI----DTIKNQNQEKEKKCfEDLKIVKEKNEDLQ---KTIKQNEETLTQTISQYNgrlsv 946
Cdd:TIGR00606  415 ADLQSKERLKQEQADEIRDEKkglgRTIELKKEILEKKQ-EELKFVIKELQQLEgssDRILELDQELRKAERELS----- 488

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  947 LTAENAMLNSKLENEKqSKERLEAEVESYHSRLAAAIHDRDQSETSKRELEL-------AFQRARDECSRLQDKMNFDVS 1019
Cdd:TIGR00606  489 KAEKNSLTETLKKEVK-SLQNEKADLDRKLRKLDQEMEQLNHHTTTRTQMEMltkdkmdKDEQIRKIKSRHSDELTSLLG 567

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1020 -------------NLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTqCQMKEMEQKYQNEQV 1086
Cdd:TIGR00606  568 yfpnkkqledwlhSKSKEINQTRDRLAKLNKELASLEQNKNHINNELESKEEQLSSYEDKLFDV-CGSQDEESDLERLKE 646

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1087 KVNK-------YIGKQESVEERLSQLQSEN----------MLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESE 1149
Cdd:TIGR00606  647 EIEKsskqramLAGATAVYSQFITQLTDENqsccpvcqrvFQTEAELQEFISDLQSKLRLAPDKLKSTESELKKKEKRRD 726

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1150 KQSLLLEERNKEL---ISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASL-EVTSRYRinLEDETQDL 1225
Cdd:TIGR00606  727 EMLGLAPGRQSIIdlkEKEIPELRNKLQKVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLtDVTIMER--FQMELKDV 804

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1226 KKKLGQIRNQLQEAQ-DRHTEAVRcaEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDEKEQLKKLMEL 1304
Cdd:TIGR00606  805 ERKIAQQAAKLQGSDlDRTVQQVN--QEKQEKQHELDTVVSKIELNRKLIQDQQEQIQHLKSKTNELKSEKLQIGTNLQR 882

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1305 KQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMDIQINKLKHKIDDLTAELETAGS 1384
Cdd:TIGR00606  883 RQQFEEQLVELSTEVQSLIREIKDAKEQDSPLETFLEKDQQEKEELISSKETSNKKAQDKVNDIKEKVKNIHGYMKDIEN 962

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1385 KClhLDTKNQILQEELLSMKTVQKKCEKLQKNKKKLEQEVINLR-----SHIERNMVELGQVKQYKQEIEERARQEIAEK 1459
Cdd:TIGR00606  963 KI--QDGKDDYLKQKETELNTVNAQLEECEKHQEKINEDMRLMRqdidtQKIQERWLQDNLTLRKRENELKEVEEELKQH 1040

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1460 LKEVNlflQAQAASQENLEQFRENNFASMKSQMEL---RIKDLESEL--SKIKTSQEDFNKTElEKYKQLYLeELKVRKS 1534
Cdd:TIGR00606 1041 LKEMG---QMQVLQMKQEHQKLEENIDLIKRNHVLalgRQKGYEKEIkhFKKELREPQFRDAE-EKYREMMI-VMRTTEL 1115


                   ....*..
gi 2217276170 1535 LSSKLTK 1541
Cdd:TIGR00606 1116 VNKDLDI 1122
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 778-1457 1.41e-08

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 59.74  E-value: 1.41e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  778 IREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDaqrqLSREQNARMLQDGILTNHLSKQKEiem 857
Cdd:pfam05483   97 IEAELKQKENKLQENRKIIEAQRKAIQELQFENEKVSLKLEEEIQENKD----LIKENNATRHLCNLLKETCARSAE--- 169

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  858 AQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDtikNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTI 937
Cdd:pfam05483  170 KTKKYEYEREETRQVYMDLNNNIEKMILAFEELRVQAE---NARLEMHFKLKEDHEKIQHLEEEYKKEINDKEKQVSLLL 246

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  938 SQYNGRlsvltaENAM--LNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMN 1015
Cdd:pfam05483  247 IQITEK------ENKMkdLTFLLEESRDKANQLEEKTKLQDENLKELIEKKDHLTKELEDIKMSLQRSMSTQKALEEDLQ 320

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1016 F---DVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALrEKTLGLERVQKDLSQTQCQMKEME-QKYQNEQVKVNKY 1091
Cdd:pfam05483  321 IatkTICQLTEEKEAQMEELNKAKAAHSFVVTEFEATTCSL-EELLRTEQQRLEKNEDQLKIITMElQKKSSELEEMTKF 399

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1092 IGKQESVEERLSQLQSENMLLRQQLDDAHNKADN--------------KEKTVINIQDQFHAI----------VQKLQAE 1147
Cdd:pfam05483  400 KNNKEVELEELKKILAEDEKLLDEKKQFEKIAEElkgkeqelifllqaREKEIHDLEIQLTAIktseehylkeVEDLKTE 479

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1148 SEKQSLlleeRNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKK 1227
Cdd:pfam05483  480 LEKEKL----KNIELTAHCDKLLLENKELTQEASDMTLELKKHQEDIINCKKQEERMLKQIENLEEKEMNLRDELESVRE 555

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1228 KLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDkieelQKNLLNANLSEDEKEQLKKLMELKQS 1307
Cdd:pfam05483  556 EFIQKGDEVKCKLDKSEENARSIEYEVLKKEKQMKILENKCNNLKKQIE-----NKNKNIEELHQENKALKKKGSAENKQ 630

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1308 LECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMDIQIN-------KLKHKIDDLTAELE 1380
Cdd:pfam05483  631 LNAYEIKVNKLELELASAKQKFEEIIDNYQKEIEDKKISEEKLLEEVEKAKAIADEAVKlqkeidkRCQHKIAEMVALME 710

                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217276170 1381 TagskclHLDTKNQILQEELLSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERARQEIA 1457
Cdd:pfam05483  711 K------HKHQYDKIIEERDSELGLYKNKEQEQSSAKAALEIELSNIKAELLSLKKQLEIEKEEKEKLKMEAKENTA 781
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
910-1482 1.43e-08

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 59.69  E-value: 1.43e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  910 EDLKIVKEKNEDLQKTIKQNEETLTQTISqyngRLSVLTAENAMLNSKLENEKQSKERLEAEVEsyhsRLAAAIHDRDQS 989
Cdd:PRK03918   179 ERLEKFIKRTENIEELIKEKEKELEEVLR----EINEISSELPELREELEKLEKEVKELEELKE----EIEELEKELESL 250

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  990 ETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEIlsQQLFKTESKLNSLEIEFhhtRDALREKTLGLERVQKDLSQ 1069
Cdd:PRK03918   251 EGSKRKLEEKIRELEERIEELKKEIEELEEKVKELKEL--KEKAEEYIKLSEFYEEY---LDELREIEKRLSRLEEEING 325

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1070 TQCQMKEMEQKyqneQVKVNKYIGKQESVEERLSQLQSENMLLrqqlDDAHNKADNKEKTVINIQDQfhaIVQKLQAESE 1149
Cdd:PRK03918   326 IEERIKELEEK----EERLEELKKKLKELEKRLEELEERHELY----EEAKAKKEELERLKKRLTGL---TPEKLEKELE 394

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1150 KqsllLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQ----------QELADTLKKQSMSEASLEVT--SRYRIN 1217
Cdd:PRK03918   395 E----LEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKkakgkcpvcgRELTEEHRKELLEEYTAELKriEKELKE 470

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1218 LEDETQDLKKKLGQIRNQLQEaQDRHTEAVRCAEKMQDHKQKLEKDN-------AKLKVTVKKQMDKIEELQKNLlnanl 1290
Cdd:PRK03918   471 IEEKERKLRKELRELEKVLKK-ESELIKLKELAEQLKELEEKLKKYNleelekkAEEYEKLKEKLIKLKGEIKSL----- 544

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1291 sEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREIT--GFKNL--LKMTRKKLNEYENGEFSfhgdLKTSQFEMDIQIN 1366
Cdd:PRK03918   545 -KKELEKLEELKKKLAELEKKLDELEEELAELLKELEelGFESVeeLEERLKELEPFYNEYLE----LKDAEKELEREEK 619

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1367 KLKhkidDLTAELETAGSKCLHLDTKNQILQEEL--LSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQY 1444
Cdd:PRK03918   620 ELK----KLEEELDKAFEELAETEKRLEELRKELeeLEKKYSEEEYEELREEYLELSRELAGLRAELEELEKRREEIKKT 695

                          570       580       590
                   ....*....|....*....|....*....|....*...
gi 2217276170 1445 KQEIEERaRQEIAEKLKEVNLFLQAQAASQENLEQFRE 1482
Cdd:PRK03918   696 LEKLKEE-LEEREKAKKELEKLEKALERVEELREKVKK 732
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 714-1334 2.61e-08

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 59.08  E-value: 2.61e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  714 LLTVKIKKMEDKVNVLQRELSET-KEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKE----EQ 788
Cdd:pfam12128  262 HLHFGYKSDETLIASRQEERQETsAELNQLLRTLDDQWKEKRDELNGELSAADAAVAKDRSELEALEDQHGAFLdadiET 341

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  789 YRKEVEVKQQLELSLQTLEMELRTVKSNLNQVvQERNDAQRQLSREQNARMLQDgiLTNHLSKQKEiemaqkkmnsensh 868
Cdd:pfam12128  342 AAADQEQLPSWQSELENLEERLKALTGKHQDV-TAKYNRRRSKIKEQNNRDIAG--IKDKLAKIRE-------------- 404

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  869 shEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTikqnEETLTQTisqyngrlsvlt 948
Cdd:pfam12128  405 --ARDRQLAVAEDDLQALESELREQLEAGKLEFNEEEYRLKSRLGELKLRLNQATAT----PELLLQL------------ 466

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  949 aenAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDK-----------MNFD 1017
Cdd:pfam12128  467 ---ENFDERIERAREEQEAANAEVERLQSELRQARKRRDQASEALRQASRRLEERQSALDELELQlfpqagtllhfLRKE 543

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1018 VSNLKDN--NEILSQQLFKT-------------ESKLNSLEI--------EFHHTRDALREKtlgLERVQKDLSQTQCQM 1074
Cdd:pfam12128  544 APDWEQSigKVISPELLHRTdldpevwdgsvggELNLYGVKLdlkridvpEWAASEEELRER---LDKAEEALQSAREKQ 620

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1075 KEMEQkyqnEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAH-NKADNKEKTVINIQDQFHAIVQKLQAESE---- 1149
Cdd:pfam12128  621 AAAEE----QLVQANGELEKASREETFARTALKNARLDLRRLFDEKqSEKDKKNKALAERKDSANERLNSLEAQLKqldk 696

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1150 KQSLLLEERNKELISecnHLKERQYQYENEKAEREVVVRQLQQELA----------DTLKKQSMSE-ASLEVTSRYRINL 1218
Cdd:pfam12128  697 KHQAWLEEQKEQKRE---ARTEKQAYWQVVEGALDAQLALLKAAIAarrsgakaelKALETWYKRDlASLGVDPDVIAKL 773

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1219 EDETQDLKKKLGQIrnqlqeAQDRHteAVRCAEKMQDHKQKLEKDNakLKVTVKKQMDKIEELQKNLlnANLSEDEKEQL 1298
Cdd:pfam12128  774 KREIRTLERKIERI------AVRRQ--EVLRYFDWYQETWLQRRPR--LATQLSNIERAISELQQQL--ARLIADTKLRR 841

                          650       660       670
                   ....*....|....*....|....*....|....*.
gi 2217276170 1299 KKLMELKQSLEcnldqemKKNVELEREITGFKNLLK 1334
Cdd:pfam12128  842 AKLEMERKASE-------KQQVRLSENLRGLRCEMS 870
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
766-1334 2.96e-08

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 58.92  E-value: 2.96e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  766 EKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSR-EQNARMLQdgi 844
Cdd:PRK03918   158 DDYENAYKNLGEVIKEIKRRIERLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREELEKlEKEVKELE--- 234

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  845 ltnhlSKQKEIEMAQKKMNSENSHSHEEEKDLSHknsmLQEEIAMLRLEIDTIKNQNQE-----KEKKCFEDLKIVKEKN 919
Cdd:PRK03918   235 -----ELKEEIEELEKELESLEGSKRKLEEKIRE----LEERIEELKKEIEELEEKVKElkelkEKAEEYIKLSEFYEEY 305

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  920 EDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLE----------------AEVESYHSRLAA-- 981
Cdd:PRK03918   306 LDELREIEKRLSRLEEEINGIEERIKELEEKEERLEELKKKLKELEKRLEeleerhelyeeakakkEELERLKKRLTGlt 385

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  982 ---AIHDRDQSETSKRELELAFQRARDECSRLQDKmnfdVSNLKDNNEILSQQlfKTESKLNSLEIEFHHTRDALREKTL 1058
Cdd:PRK03918   386 pekLEKELEELEKAKEEIEEEISKITARIGELKKE----IKELKKAIEELKKA--KGKCPVCGRELTEEHRKELLEEYTA 459

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1059 GLERVQKDLSQTqcqmKEMEQKYQNEQVKVNKYIGKQ-------------ESVEERLSQLQSENM--------LLRQQLD 1117
Cdd:PRK03918   460 ELKRIEKELKEI----EEKERKLRKELRELEKVLKKEseliklkelaeqlKELEEKLKKYNLEELekkaeeyeKLKEKLI 535

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1118 DAHNKADNKEKTVINIQD---QFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYEnEKAEREVVVRQLQQEL 1194
Cdd:PRK03918   536 KLKGEIKSLKKELEKLEElkkKLAELEKKLDELEEELAELLKELEELGFESVEELEERLKELE-PFYNEYLELKDAEKEL 614

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1195 ADTLKKQSMSEASLEVTsryrinlEDETQDLKKKLGQIRNQLQEAQDRHTEAVRcaEKMQDHKQKLEKDNAKLKVTVKKQ 1274
Cdd:PRK03918   615 EREEKELKKLEEELDKA-------FEELAETEKRLEELRKELEELEKKYSEEEY--EELREEYLELSRELAGLRAELEEL 685

                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1275 MDKIEELQKNLlnanlsEDEKEQLKKLMELKQSLEcNLDQEMKKNVELEREITGFKNLLK 1334
Cdd:PRK03918   686 EKRREEIKKTL------EKLKEELEEREKAKKELE-KLEKALERVEELREKVKKYKALLK 738
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 73-218 3.77e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 57.67  E-value: 3.77e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170   73 LNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPNLADVHGNTALHY 152
Cdd:PHA02874   117 VNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHN 196

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217276170  153 AVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSgKKQQMVEFLIKKKA-NVNAVDKLESSHQLI 218
Cdd:PHA02874   197 AAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAII-HNRSAIELLINNASiNDQDIDGSTPLHHAI 262
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 873-1563 8.17e-08

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 57.42  E-value: 8.17e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  873 EKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEkNEDLqktIKQNEETltqtiSQYNGRLSVLTAENA 952
Cdd:pfam05483   98 EAELKQKENKLQENRKIIEAQRKAIQELQFENEKVSLKLEEEIQE-NKDL---IKENNAT-----RHLCNLLKETCARSA 168

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  953 MLNSKLENEKQSKERLEAEVESYHSRLAAAIHD-RDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQ 1031
Cdd:pfam05483  169 EKTKKYEYEREETRQVYMDLNNNIEKMILAFEElRVQAENARLEMHFKLKEDHEKIQHLEEEYKKEINDKEKQVSLLLIQ 248

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1032 LFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQlqsenml 1111
Cdd:pfam05483  249 ITEKENKMKDLTFLLEESRDKANQLEEKTKLQDENLKELIEKKDHLTKELEDIKMSLQRSMSTQKALEEDLQI------- 321

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1112 lrqqlddahnkadnKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQ 1191
Cdd:pfam05483  322 --------------ATKTICQLTEEKEAQMEELNKAKAAHSFVVTEFEATTCSLEELLRTEQQRLEKNEDQLKIITMELQ 387

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1192 QEladtlkkqsmsEASLEVTSRYRINLEDETQDLKKKLG----------QIRNQLQEAQDRHTEAVRCAEKMQDHKQKLE 1261
Cdd:pfam05483  388 KK-----------SSELEEMTKFKNNKEVELEELKKILAedeklldekkQFEKIAEELKGKEQELIFLLQAREKEIHDLE 456

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1262 KDNAKLKVTVKKQMDKIEELQKNLLNANLSEDEKEQLKKLMELKQSLECNLDQEMKKNVELERE-ITGFKNLLKMTRKKL 1340
Cdd:pfam05483  457 IQLTAIKTSEEHYLKEVEDLKTELEKEKLKNIELTAHCDKLLLENKELTQEASDMTLELKKHQEdIINCKKQEERMLKQI 536

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1341 NEYENGEFSFHGDLKTSQFEMDIQINKLKHKIDDLTAELETAGSKCLHLDTKNQILQEELLSMKtvqKKCEKLQKNKKKL 1420
Cdd:pfam05483  537 ENLEEKEMNLRDELESVREEFIQKGDEVKCKLDKSEENARSIEYEVLKKEKQMKILENKCNNLK---KQIENKNKNIEEL 613

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1421 EQE--VINLRSHIERNMVELGQVKQYKQEIE-ERARQEIAEKLKEVNLFLQAQAASQENLEQFRENNFASMKSQMEL--- 1494
Cdd:pfam05483  614 HQEnkALKKKGSAENKQLNAYEIKVNKLELElASAKQKFEEIIDNYQKEIEDKKISEEKLLEEVEKAKAIADEAVKLqke 693

                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2217276170 1495 -------RIKDLESELSKIKTSQEDF---NKTELEKYKQLYLEELKVRKSLSSKLTKTNERLAEVNTKLLVEKQQSRSL 1563
Cdd:pfam05483  694 idkrcqhKIAEMVALMEKHKHQYDKIieeRDSELGLYKNKEQEQSSAKAALEIELSNIKAELLSLKKQLEIEKEEKEKL 772
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 783-1532 1.22e-07

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 56.72  E-value: 1.22e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  783 RRKEEQYRKEVEVKQQLELSLQtLEMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQKKM 862
Cdd:pfam01576    2 RQEEEMQAKEEELQKVKERQQK-AESELKELEKKHQQLCEEKNALQEQLQAETELCAEAEEMRARLAARKQELEEILHEL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  863 NSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQE----------KEKKCFEDLKIVKEKNEDLQKTIKQNEEt 932
Cdd:pfam01576   81 ESRLEEEEERSQQLQNEKKKMQQHIQDLEEQLDEEEAARQKlqlekvtteaKIKKLEEDILLLEDQNSKLSKERKLLEE- 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  933 ltqtisqyngRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQD 1012
Cdd:pfam01576  160 ----------RISEFTSNLAEEEEKAKSLSKLKNKHEAMISDLEERLKKEEKGRQELEKAKRKLEGESTDLQEQIAELQA 229

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1013 KMnfdvsnlkdnnEILSQQLFKTESKLNSLEiefhhtrDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYI 1092
Cdd:pfam01576  230 QI-----------AELRAQLAKKEEELQAAL-------ARLEEETAQKNNALKKIRELEAQISELQEDLESERAARNKAE 291

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1093 GKQESVEERLSQLQSEnmlLRQQLDDAHNKAD---NKEKTVIN----IQDQFHAIVQKLQAESEKQSLLLEERNKELise 1165
Cdd:pfam01576  292 KQRRDLGEELEALKTE---LEDTLDTTAAQQElrsKREQEVTElkkaLEEETRSHEAQLQEMRQKHTQALEELTEQL--- 365

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1166 cNHLKERQYQYENEKAEREVVVRQLQQELadtlkkQSMSEASLEVTSRyRINLEDETQDLKKKLGQIRNQLQEAQDRHTE 1245
Cdd:pfam01576  366 -EQAKRNKANLEKAKQALESENAELQAEL------RTLQQAKQDSEHK-RKKLEGQLQELQARLSESERQRAELAEKLSK 437

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1246 AVRCAEKMQDHKQKLEKDNAKLK---VTVKKQMDKIEELQKNLLNANLSEDEKeqLKKLMELKQSLECNLDQEMKKNVEL 1322
Cdd:pfam01576  438 LQSELESVSSLLNEAEGKNIKLSkdvSSLESQLQDTQELLQEETRQKLNLSTR--LRQLEDERNSLQEQLEEEEEAKRNV 515

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1323 EREITGFKNLLKMTRKKLNEYENGEFSFHGDLKtsqfemdiqinKLKHKIDDLTAELETAGSKCLHLDTKNQILQEEL-- 1400
Cdd:pfam01576  516 ERQLSTLQAQLSDMKKKLEEDAGTLEALEEGKK-----------RLQRELEALTQQLEEKAAAYDKLEKTKNRLQQELdd 584

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1401 LSMKTVQKK--CEKLQKNKKKLEQEVINlrshiERNMVelgqvkqyKQEIEERARQEIAEKLKEVNlFLQAQAASQENLE 1478
Cdd:pfam01576  585 LLVDLDHQRqlVSNLEKKQKKFDQMLAE-----EKAIS--------ARYAEERDRAEAEAREKETR-ALSLARALEEALE 650

                          730       740       750       760       770
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2217276170 1479 QfrennfasmKSQMELRIKDLESELSKIKTSQEDFNKT--ELEKYKQLY---LEELKVR 1532
Cdd:pfam01576  651 A---------KEELERTNKQLRAEMEDLVSSKDDVGKNvhELERSKRALeqqVEEMKTQ 700
Ank_2 pfam12796
Ankyrin repeats (3 copies);
150-210 1.40e-07

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 50.88  E-value: 1.40e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217276170  150 LHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIkKKANVNAVDK 210
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLL-EHADVNLKDN 60
Ank_4 pfam13637
Ankyrin repeats (many copies);
113-166 2.36e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 48.81  E-value: 2.36e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2217276170  113 NRTALMKAVQCQEEKCATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLL 166
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1017-1549 2.77e-07

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 55.46  E-value: 2.77e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1017 DVSNLKDNNEilsQQLFKTESKLNSLEIEfhhtRDALREKTLGLERVQKDLsqtqcqmKEMEQKYQNEQVKVNKYIGKQE 1096
Cdd:PRK03918   190 NIEELIKEKE---KELEEVLREINEISSE----LPELREELEKLEKEVKEL-------EELKEEIEELEKELESLEGSKR 255

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1097 SVEERLSQLQSENMLLRQQLDDAHNKAdnKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQY 1176
Cdd:PRK03918   256 KLEEKIRELEERIEELKKEIEELEEKV--KELKELKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKEL 333

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1177 ENEKAErevvVRQLQQELADTLKKQSMSEASLEVTSRYRiNLEDETQDLKKKLGQirNQLQEAQDRHTEAVRCAEKMQDH 1256
Cdd:PRK03918   334 EEKEER----LEELKKKLKELEKRLEELEERHELYEEAK-AKKEELERLKKRLTG--LTPEKLEKELEELEKAKEEIEEE 406

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1257 KQKLEKDNAKLKVTVKKQMDKIEELQKN-----LLNANLSEDEKEQL--------KKLMELKQSLECNLDQEMKKNVELE 1323
Cdd:PRK03918   407 ISKITARIGELKKEIKELKKAIEELKKAkgkcpVCGRELTEEHRKELleeytaelKRIEKELKEIEEKERKLRKELRELE 486

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1324 REITGFKNLLKMtRKKLNEYENGEFSFHGdlktsqfemdIQINKLKHKiddlTAELETAGSKCLHLDTKNQILQEELLSM 1403
Cdd:PRK03918   487 KVLKKESELIKL-KELAEQLKELEEKLKK----------YNLEELEKK----AEEYEKLKEKLIKLKGEIKSLKKELEKL 551

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1404 KTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVE-LGQVKQYKQEIEERARQEIaeKLKEVNLFLQAQAASQENLEQFRE 1482
Cdd:PRK03918   552 EELKKKLAELEKKLDELEEELAELLKELEELGFEsVEELEERLKELEPFYNEYL--ELKDAEKELEREEKELKKLEEELD 629

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217276170 1483 NNFAsmksQMELRIKDLESELSKIKTSQEDFNKTELEKYKQLYLEELKVRKSLSSKLTKTNERLAEV 1549
Cdd:PRK03918   630 KAFE----ELAETEKRLEELRKELEELEKKYSEEEYEELREEYLELSRELAGLRAELEELEKRREEI 692
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
696-1246 8.20e-07

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 53.89  E-value: 8.20e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  696 DAALSCERLLELKKNHCELLTVKIKKMEDK-----VNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRN 770
Cdd:PRK02224   173 DARLGVERVLSDQRGSLDQLKAQIEEKEEKdlherLNGLESELAELDEEIERYEEQREQARETRDEADEVLEEHEERREE 252

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  771 ADTLYEKIRE------QLRRKEEQYRKEVEVKQQLELSLQTLEMELRTvKSNLNQVVQERNDAQRQ-LSREQNArmLQDG 843
Cdd:PRK02224   253 LETLEAEIEDlretiaETEREREELAEEVRDLRERLEELEEERDDLLA-EAGLDDADAEAVEARREeLEDRDEE--LRDR 329

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  844 ILtnhlskqkEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKnqnqekekkcfEDLKIVKEKNEDLQ 923
Cdd:PRK02224   330 LE--------ECRVAAQAHNEEAESLREDADDLEERAEELREEAAELESELEEAR-----------EAVEDRREEIEELE 390

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  924 KTIKQNEETLTQTISQYNGrlsvLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAA--------------------- 982
Cdd:PRK02224   391 EEIEELRERFGDAPVDLGN----AEDFLEELREERDELREREAELEATLRTARERVEEAealleagkcpecgqpvegsph 466

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  983 IHDRDQSETSKRELELAFQRARDECSRLQDKMNfdvsnlkdnneiLSQQLFKTESKLNSLE---------IEFHHTRDAL 1053
Cdd:PRK02224   467 VETIEEDRERVEELEAELEDLEEEVEEVEERLE------------RAEDLVEAEDRIERLEerredleelIAERRETIEE 534

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1054 REKTLGLERVQKDLSQTQCQMK-----EMEQKYQNEQVKVNKYIGKQESVEERLSQLQSenmlLRQQLDDAHNKADN--- 1125
Cdd:PRK02224   535 KRERAEELRERAAELEAEAEEKreaaaEAEEEAEEAREEVAELNSKLAELKERIESLER----IRTLLAAIADAEDEier 610

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1126 ---KEKTVINIQDQFHaivQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAERevvVRQLQQELADTLKKQS 1202
Cdd:PRK02224   611 lreKREALAELNDERR---ERLAEKRERKRELEAEFDEARIEEAREDKERAEEYLEQVEEK---LDELREERDDLQAEIG 684

                          570       580       590       600
                   ....*....|....*....|....*....|....*....|....
gi 2217276170 1203 MSEASLEvtsryrinledETQDLKKKLGQIRNQLQEAQDRHTEA 1246
Cdd:PRK02224   685 AVENELE-----------ELEELRERREALENRVEALEALYDEA 717
PHA03095 PHA03095
ankyrin-like protein; Provisional
 66-210 8.29e-07

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 53.49  E-value: 8.29e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170   66 LLLRK-NGLNDRDKMNRTALHLACANGHP--EVVTLLVDRKCQLNVCDNENRTAL-MKAVQCQeekCATI----LLEHGA 137
Cdd:PHA03095   172 LLIDAgADVYAVDDRFRSLLHHHLQSFKPraRIVRELIRAGCDPAATDMLGNTPLhSMATGSS---CKRSlvlpLLIAGI 248

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217276170  138 DPNLADVHGNTALHYA-VYNEDISVAtKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKANVNAVDK 210
Cdd:PHA03095   249 SINARNRYGQTPLHYAaVFNNPRACR-RLIALGADINAVSSDGNTPLSLMVRNNNGRAVRAALAKNPSAETVAA 321
Ank_5 pfam13857
Ankyrin repeats (many copies);
132-186 1.09e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 46.96  E-value: 1.09e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2217276170  132 LLEHG-ADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLA 186
Cdd:pfam13857    1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 121-292 1.38e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 53.14  E-value: 1.38e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  121 VQCQEEKCATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIK 200
Cdd:PHA02876   153 IQQDELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIID 232

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  201 KKANVNAVDkLESSHQLISEYKEERIPKHSSQNS-NSVDESSEDSLSRLSGKPGVDDSWPTSDDEDLNFDTKNVPKPSLA 279
Cdd:PHA02876   233 NRSNINKND-LSLLKAIRNEDLETSLLLYDAGFSvNSIDDCKNTPLHHASQAPSLSRLVPKLLERGADVNAKNIKGETPL 311

                          170
                   ....*....|...
gi 2217276170  280 KLMTASQQSRKNL 292
Cdd:PHA02876   312 YLMAKNGYDTENI 324
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 691-1363 1.86e-06

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 53.05  E-value: 1.86e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  691 LLKIQDAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRN 770
Cdd:pfam02463  355 EEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELELKSEEEKEAQLLLELARQLEDLLKEEKKEELEILEE 434

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  771 A--DTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEmELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGILTNH 848
Cdd:pfam02463  435 EeeSIELKQGKLTEEKEELEKQELKLLKDELELKKSEDL-LKETQLVKLQEQLELLLSRQKLEERSQKESKARSGLKVLL 513

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  849 LSKQKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQ 928
Cdd:pfam02463  514 ALIKDGVGGRIISAHGRLGDLGVAVENYKVAISTAVIVEVSATADEVEERQKLVRALTELPLGARKLRLLIPKLKLPLKS 593

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  929 NEETLTQTISQYNGRLsvLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECS 1008
Cdd:pfam02463  594 IAVLEIDPILNLAQLD--KATLEADEDDKRAKVVEGILKDTELTKLKESAKAKESGLRKGVSLEEGLAEKSEVKASLSEL 671

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1009 RLQDKmnfdvsNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKV 1088
Cdd:pfam02463  672 TKELL------EIQELQEKAESELAKEEILRRQLEIKKKEQREKEELKKLKLEAEELLADRVQEAQDKINEELKLLKQKI 745

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1089 NKYIGK-QESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKELISECN 1167
Cdd:pfam02463  746 DEEEEEeEKSRLKKEEKEEEKSELSLKEKELAEEREKTEKLKVEEEKEEKLKAQEEELRALEEELKEEAELLEEEQLLIE 825

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1168 HLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEA-----SLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDR 1242
Cdd:pfam02463  826 QEEKIKEEELEELALELKEEQKLEKLAEEELERLEEEITkeellQELLLKEEELEEQKLKDELESKEEKEKEEKKELEEE 905

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1243 HTEAV-------RCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDEKEQLKKL---------MELKQ 1306
Cdd:pfam02463  906 SQKLNlleekenEIEERIKEEAEILLKYEEEPEELLLEEADEKEKEENNKEEEEERNKRLLLAKEElgkvnlmaiEEFEE 985

                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2217276170 1307 SLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMDI 1363
Cdd:pfam02463  986 KEERYNKDELEKERLEEEKKKLIRAIIEETCQRLKEFLELFVSINKGWNKVFFYLEL 1042
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1276-1567 2.22e-06

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 52.63  E-value: 2.22e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1276 DKIEELQKNLLNANLsEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSfhgdLK 1355
Cdd:COG1196    220 EELKELEAELLLLKL-RELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYE----LL 294

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1356 TSQFEMDIQINKLKHKIDDLTAELETAGSKCLHLDTKNQILQEELLSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNM 1435
Cdd:COG1196    295 AELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAEL 374

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1436 VELGQVKQYKQEIEERARQEIAEKLKEVNLFLQAQAASQENLEQFRENnfasmKSQMELRIKDLESELSKIKTSQEDfnk 1515
Cdd:COG1196    375 AEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEE-----LEELEEALAELEEEEEEEEEALEE--- 446

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2217276170 1516 tELEKYKQLYLEELKVRKSLSSKLTKTNERLAEVNtKLLVEKQQSRSLFTTL 1567
Cdd:COG1196    447 -AAEEEAELEEEEEALLELLAELLEEAALLEAALA-ELLEELAEAAARLLLL 496
Ank_5 pfam13857
Ankyrin repeats (many copies);
68-117 2.42e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 46.19  E-value: 2.42e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2217276170   68 LRKNG---LNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTAL 117
Cdd:pfam13857    1 LLEHGpidLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
Ank_4 pfam13637
Ankyrin repeats (many copies);
50-100 2.46e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 46.11  E-value: 2.46e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2217276170   50 IHKAASAGNVAKVQqilLLRKNG--LNDRDKMNRTALHLACANGHPEVVTLLV 100
Cdd:pfam13637    5 LHAAAASGHLELLR---LLLEKGadINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 56-237 4.19e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 51.12  E-value: 4.19e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170   56 AGNVAKVQQILLLRKNGLNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQ------------- 122
Cdd:PHA02874    11 SGDIEAIEKIIKNKGNCINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKigahdiikllidn 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  123 ----------CQEEKCATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQ 192
Cdd:PHA02874    91 gvdtsilpipCIEKDMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFF 170

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*.
gi 2217276170  193 QMVEFLIKKKANVNAVD-KLESSHQLISEYKEERIPKHSSQNSNSV 237
Cdd:PHA02874   171 DIIKLLLEKGAYANVKDnNGESPLHNAAEYGDYACIKLLIDHGNHI 216
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 712-1325 4.73e-06

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 51.65  E-value: 4.73e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  712 CELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFslnQEEEKRRNADTLYEKIREQLRRKEEQYRK 791
Cdd:pfam05483  157 CNLLKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMILAFEELRV---QAENARLEMHFKLKEDHEKIQHLEEEYKK 233

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  792 EVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNarmLQDGILTNHLSKQKEIEMAQKKMNSENSHSHE 871
Cdd:pfam05483  234 EINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKANQLEEKTK---LQDENLKELIEKKDHLTKELEDIKMSLQRSMS 310

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  872 EEKDLSHKNSMLQEEIAMLRLEidtiKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAEN 951
Cdd:pfam05483  311 TQKALEEDLQIATKTICQLTEE----KEAQMEELNKAKAAHSFVVTEFEATTCSLEELLRTEQQRLEKNEDQLKIITMEL 386

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  952 AMLNSKLENEKQSKERLEAEVESYHSRLA---AAIHDRDQSETSKREL-----ELAFQRARDECSRLQDKMNFDVSNLKD 1023
Cdd:pfam05483  387 QKKSSELEEMTKFKNNKEVELEELKKILAedeKLLDEKKQFEKIAEELkgkeqELIFLLQAREKEIHDLEIQLTAIKTSE 466

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1024 NNEILSQQLFKTE---SKLNSLEIEFHHTRDALREK---------TLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKY 1091
Cdd:pfam05483  467 EHYLKEVEDLKTElekEKLKNIELTAHCDKLLLENKeltqeasdmTLELKKHQEDIINCKKQEERMLKQIENLEEKEMNL 546

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1092 IGKQESVEERLSQLQSEnmlLRQQLDDAHNKADNKEKTVINIQDQFHAIVQK---LQAESEKQSLLLEernkELISECNH 1168
Cdd:pfam05483  547 RDELESVREEFIQKGDE---VKCKLDKSEENARSIEYEVLKKEKQMKILENKcnnLKKQIENKNKNIE----ELHQENKA 619

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1169 LKERQYQYENEKAEREVVVRQLQQELADTLKKQSmseaslEVTSRYRINLEDETQDLKKKLGQIrnqlQEAQDRHTEAVR 1248
Cdd:pfam05483  620 LKKKGSAENKQLNAYEIKVNKLELELASAKQKFE------EIIDNYQKEIEDKKISEEKLLEEV----EKAKAIADEAVK 689

                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2217276170 1249 CAEKMQDHKQKLEKDNAKLKVTVKKQMDKI-EELQKNLLNANLSEDEKEQLKKLMELKQSLECNLDQEMKKNVELERE 1325
Cdd:pfam05483  690 LQKEIDKRCQHKIAEMVALMEKHKHQYDKIiEERDSELGLYKNKEQEQSSAKAALEIELSNIKAELLSLKKQLEIEKE 767
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 585-1273 5.23e-06

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 51.59  E-value: 5.23e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  585 EKEKRTSKESVNSPVFGKASLLTGGLLQVDDDSSLSEIDEDEGRPTKKTSNEKNKVKNQIQSMDDvddltQSSETASEDC 664
Cdd:TIGR01612 1061 EKEIGKNIELLNKEILEEAEINITNFNEIKEKLKHYNFDDFGKEENIKYADEINKIKDDIKNLDQ-----KIDHHIKALE 1135

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  665 ELPHSSyknfmlliEQLGMECKDSVS-LLKIQDAALSCERLLELKKNHCELLTV--KIKKMEDKVNVLQRELSETKEIKS 741
Cdd:TIGR01612 1136 EIKKKS--------ENYIDEIKAQINdLEDVADKAISNDDPEEIEKKIENIVTKidKKKNIYDEIKKLLNEIAEIEKDKT 1207

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  742 QLEHQK---VEWERELCSLrFSLNQEEEKRRNADTL-----YEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTV 813
Cdd:TIGR01612 1208 SLEEVKginLSYGKNLGKL-FLEKIDEEKKKSEHMIkameaYIEDLDEIKEKSPEIENEMGIEMDIKAEMETFNISHDDD 1286

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  814 KSnlNQVVQERNDAQRQLSREQNARMLQDgiltnhLSKQKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRL- 892
Cdd:TIGR01612 1287 KD--HHIISKKHDENISDIREKSLKIIED------FSEESDINDIKKELQKNLLDAQKHNSDINLYLNEIANIYNILKLn 1358

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  893 EIDTIKNQNQEKEKKCFEDLKIVK---EKNEDLQKTIKQNE--ETLTQTISQyngrlsvlTAENAMLNSKLENEKQSKER 967
Cdd:TIGR01612 1359 KIKKIIDEVKEYTKEIEENNKNIKdelDKSEKLIKKIKDDInlEECKSKIES--------TLDDKDIDECIKKIKELKNH 1430

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  968 LEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRA----RDECSRLQDKMNFDVSNLKDNNEilSQQLFKTESKLNSLE 1043
Cdd:TIGR01612 1431 ILSEESNIDTYFKNADENNENVLLLFKNIEMADNKSqhilKIKKDNATNDHDFNINELKEHID--KSKGCKDEADKNAKA 1508

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1044 IEfhhtrdalREKTLgLERVQKDLSQTQCQMKEMEQKYQNEQVKV-------------NKYIGKQESVEERLSQLQSENM 1110
Cdd:TIGR01612 1509 IE--------KNKEL-FEQYKKDVTELLNKYSALAIKNKFAKTKKdseiiikeikdahKKFILEAEKSEQKIKEIKKEKF 1579

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1111 llrqQLDDAHNKADNKEKTVINIQdqfhaivqkLQAESEKQSLLLEERNKELISECnhLKERQyqyENEKAEREVVVRQL 1190
Cdd:TIGR01612 1580 ----RIEDDAAKNDKSNKAAIDIQ---------LSLENFENKFLKISDIKKKINDC--LKETE---SIEKKISSFSIDSQ 1641

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1191 QQELADTLKKQSMSEASLEVTSRYRINLED---ETQDLKKKLGQIRNQLQEAQDRHTEAV--RCAEKMQDHKQKLEKDNA 1265
Cdd:TIGR01612 1642 DTELKENGDNLNSLQEFLESLKDQKKNIEDkkkELDELDSEIEKIEIDVDQHKKNYEIGIieKIKEIAIANKEEIESIKE 1721


                   ....*...
gi 2217276170 1266 KLKVTVKK 1273
Cdd:TIGR01612 1722 LIEPTIEN 1729
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 82-202 6.02e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 51.17  E-value: 6.02e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170   82 TALHLACANGHPEVVTLLVDRKCQLN------VCDNENRTALMK--------AVQCQEEKCATILLEHGADPNLADVHGN 147
Cdd:cd22192     91 TALHIAVVNQNLNLVRELIARGADVVspratgTFFRPGPKNLIYygehplsfAACVGNEEIVRLLIEHGADIRAQDSLGN 170

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2217276170  148 TALHYAVYNEDISVATK----LLLYDANIEA------KNKDDLTPLLLAVSGKKQQMVEFLIKKK 202
Cdd:cd22192    171 TVLHILVLQPNKTFACQmydlILSYDKEDDLqpldlvPNNQGLTPFKLAAKEGNIVMFQHLVQKR 235
PTZ00121 PTZ00121
MAEBL; Provisional
 1073-1558 6.06e-06

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 51.30  E-value: 6.06e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1073 QMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAeSEKQS 1152
Cdd:PTZ00121  1288 EKKKADEAKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEA-AEEKA 1366

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1153 LLLEERNKELISECNHLKERQYqyENEKAEREVVVRQLQQELADTLKKQSMSEASLEvTSRYRINLEDETQDLKKKLGQI 1232
Cdd:PTZ00121  1367 EAAEKKKEEAKKKADAAKKKAE--EKKKADEAKKKAEEDKKKADELKKAAAAKKKAD-EAKKKAEEKKKADEAKKKAEEA 1443

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1233 RnQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMD----KIEELQKNLLNANLSEDEK---EQLKKLMELK 1305
Cdd:PTZ00121  1444 K-KADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADeakkKAEEAKKKADEAKKAAEAKkkaDEAKKAEEAK 1522

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1306 QSLECNLDQEMKKNVELER--------EITGFKNLLKM-TRKKLNEYENGEFSFHGDLKTSQFEMDIQiNKLKHKIDDLT 1376
Cdd:PTZ00121  1523 KADEAKKAEEAKKADEAKKaeekkkadELKKAEELKKAeEKKKAEEAKKAEEDKNMALRKAEEAKKAE-EARIEEVMKLY 1601

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1377 AELETAGSKCLHLDTKNQILQEELLSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQE----IEERA 1452
Cdd:PTZ00121  1602 EEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEdkkkAEEAK 1681

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1453 RQEIAEKLKEVNLFLQAQAASQenLEQFRENNFASMKSQMELRikdLESELSKIKTSQEDfNKTELEKYKQlylEELKVR 1532
Cdd:PTZ00121  1682 KAEEDEKKAAEALKKEAEEAKK--AEELKKKEAEEKKKAEELK---KAEEENKIKAEEAK-KEAEEDKKKA---EEAKKD 1752

                          490       500
                   ....*....|....*....|....*.
gi 2217276170 1533 KSLSSKLTKTNERLAEVNTKLLVEKQ 1558
Cdd:PTZ00121  1753 EEEKKKIAHLKKEEEKKAEEIRKEKE 1778
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 716-1376 6.11e-06

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 51.20  E-value: 6.11e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  716 TVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEV 795
Cdd:TIGR00606  397 TLVIERQEDEAKTAAQLCADLQSKERLKQEQADEIRDEKKGLGRTIELKKEILEKKQEELKFVIKELQQLEGSSDRILEL 476

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  796 KQQLELSLQTL-EMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQKKMNSENSHSHEEEK 874
Cdd:TIGR00606  477 DQELRKAERELsKAEKNSLTETLKKEVKSLQNEKADLDRKLRKLDQEMEQLNHHTTTRTQMEMLTKDKMDKDEQIRKIKS 556

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  875 DLSHKNSMLQEEIAMLRLEIDTIKNQNQEKE--KKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRL----SVLT 948
Cdd:TIGR00606  557 RHSDELTSLLGYFPNKKQLEDWLHSKSKEINqtRDRLAKLNKELASLEQNKNHINNELESKEEQLSSYEDKLfdvcGSQD 636

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  949 AENAMLNSKLENEKQSKER--LEAEVESYHSRLAAAIH---------DRD-QSETSKRELELAFQRARDECSRLQDKMNF 1016
Cdd:TIGR00606  637 EESDLERLKEEIEKSSKQRamLAGATAVYSQFITQLTDenqsccpvcQRVfQTEAELQEFISDLQSKLRLAPDKLKSTES 716

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1017 DVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQV------KVNK 1090
Cdd:TIGR00606  717 ELKKKEKRRDEMLGLAPGRQSIIDLKEKEIPELRNKLQKVNRDIQRLKNDIEEQETLLGTIMPEEESAKVcltdvtIMER 796

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1091 YIGKQESVEERLSQLQSEN-----MLLRQQLDDAHNKADNKEKTVIniqdQFHAIVQKLQAESEKQSLLLEERNKELISE 1165
Cdd:TIGR00606  797 FQMELKDVERKIAQQAAKLqgsdlDRTVQQVNQEKQEKQHELDTVV----SKIELNRKLIQDQQEQIQHLKSKTNELKSE 872

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1166 CNHLKE---RQYQYENEKAEREVVVRQLQQELAD---------TLKKQSMSEASLEVTSRYRIN--LEDETQDLKKKLGQ 1231
Cdd:TIGR00606  873 KLQIGTnlqRRQQFEEQLVELSTEVQSLIREIKDakeqdspleTFLEKDQQEKEELISSKETSNkkAQDKVNDIKEKVKN 952

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1232 -------IRNQLQEAQDRH--------TEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDEKE 1296
Cdd:TIGR00606  953 ihgymkdIENKIQDGKDDYlkqketelNTVNAQLEECEKHQEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRENELKE 1032

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1297 QLKKLME-LKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQF--------EMDIQINK 1367
Cdd:TIGR00606 1033 VEEELKQhLKEMGQMQVLQMKQEHQKLEENIDLIKRNHVLALGRQKGYEKEIKHFKKELREPQFrdaeekyrEMMIVMRT 1112


                   ....*....
gi 2217276170 1368 LKHKIDDLT 1376
Cdd:TIGR00606 1113 TELVNKDLD 1121
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 778-1569 8.21e-06

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 50.82  E-value: 8.21e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  778 IREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERND----AQRQLSREQNARMLQ------------ 841
Cdd:TIGR00606  222 IRDQITSKEAQLESSREIVKSYENELDPLKNRLKEIEHNLSKIMKLDNEikalKSRKKQMEKDNSELElkmekvfqgtde 301

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  842 --DGILTNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEK--------------- 904
Cdd:TIGR00606  302 qlNDLYHNHQRTVREKERELVDCQRELEKLNKERRLLNQEKTELLVEQGRLQLQADRHQEHIRARdsliqslatrleldg 381

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  905 -EKKCFEDLKI------VKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHS 977
Cdd:TIGR00606  382 fERGPFSERQIknfhtlVIERQEDEAKTAAQLCADLQSKERLKQEQADEIRDEKKGLGRTIELKKEILEKKQEELKFVIK 461

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  978 RLAAAihdrDQSETSKRELELAFQRARDECSRLQDKMNfdvsnlkdnneilSQQLFKTESKLNSLEIEFHHTRDALREKT 1057
Cdd:TIGR00606  462 ELQQL----EGSSDRILELDQELRKAERELSKAEKNSL-------------TETLKKEVKSLQNEKADLDRKLRKLDQEM 524

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1058 LGLERVQKDLSQTQCQMKEMEQKYQneQVKVNKYIGKQESVEerlsqlQSENMLLRQQLDDAHNKADNKektvINIQDQF 1137
Cdd:TIGR00606  525 EQLNHHTTTRTQMEMLTKDKMDKDE--QIRKIKSRHSDELTS------LLGYFPNKKQLEDWLHSKSKE----INQTRDR 592

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1138 HAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAErEVVVRQLQQELADTLKKQSMSEASLEVTSRYRIN 1217
Cdd:TIGR00606  593 LAKLNKELASLEQNKNHINNELESKEEQLSSYEDKLFDVCGSQDE-ESDLERLKEEIEKSSKQRAMLAGATAVYSQFITQ 671

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1218 LEDETQD---LKKKLGQIRNQLQEAQDRHTEAVRCA----EKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLlnANL 1290
Cdd:TIGR00606  672 LTDENQSccpVCQRVFQTEAELQEFISDLQSKLRLApdklKSTESELKKKEKRRDEMLGLAPGRQSIIDLKEKEI--PEL 749

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1291 SEDEKEQLKKLMELKQSLECNLDQEMKKNVELERE---------ITGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQF-- 1359
Cdd:TIGR00606  750 RNKLQKVNRDIQRLKNDIEEQETLLGTIMPEEESAkvcltdvtiMERFQMELKDVERKIAQQAAKLQGSDLDRTVQQVnq 829

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1360 ---EMDIQINKLKHKIDDLTAELETAGSKCLHLDTKNQILQEELLSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMV 1436
Cdd:TIGR00606  830 ekqEKQHELDTVVSKIELNRKLIQDQQEQIQHLKSKTNELKSEKLQIGTNLQRRQQFEEQLVELSTEVQSLIREIKDAKE 909

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1437 ELGQVKQYKQEIEERARQEIAEK---LKEVNLFLQAQAASQENLEQFRENNFASMKSQMELRIKDLESELSKIKTSQEdf 1513
Cdd:TIGR00606  910 QDSPLETFLEKDQQEKEELISSKetsNKKAQDKVNDIKEKVKNIHGYMKDIENKIQDGKDDYLKQKETELNTVNAQLE-- 987

                          810       820       830       840       850
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2217276170 1514 nktELEKYKQLYLEELKVRKSlSSKLTKTNERLAEVNTKLLVEKQQSRSLFTTLTT 1569
Cdd:TIGR00606  988 ---ECEKHQEKINEDMRLMRQ-DIDTQKIQERWLQDNLTLRKRENELKEVEEELKQ 1039
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 979-1242 1.26e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 49.38  E-value: 1.26e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  979 LAAAIHDRDQSETSKRELELAFQRARDECSRLQDKmnfdVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTL 1058
Cdd:COG4942     15 AAAQADAAAEAEAELEQLQQEIAELEKELAALKKE----EKALLKQLAALERRIAALARRIRALEQELAALEAELAELEK 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1059 GLERVQKDLSQTQCQMKEMEQKYQNeqvkvnkyIGKQESVEERLSQLQSENMLLRQQLDDAHNKADnkektviniQDQFH 1138
Cdd:COG4942     91 EIAELRAELEAQKEELAELLRALYR--------LGRQPPLALLLSPEDFLDAVRRLQYLKYLAPAR---------REQAE 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1139 AIVQKLQAESEKQSLLLEERnKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSmseaslevtsryriNL 1218
Cdd:COG4942    154 ELRADLAELAALRAELEAER-AELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELA--------------EL 218

                          250       260
                   ....*....|....*....|....
gi 2217276170 1219 EDETQDLKKKLGQIRNQLQEAQDR 1242
Cdd:COG4942    219 QQEAEELEALIARLEAEAAAAAER 242
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 82-202 1.28e-05

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 50.08  E-value: 1.28e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170   82 TALHLACANGHPEVVTLLVDRKCQLNV---CD-------------NENRTALMKAVQcqEEKCATILLEHGADPNLADVH 145
Cdd:TIGR00870  130 TALHLAAHRQNYEIVKLLLERGASVPAracGDffvksqgvdsfyhGESPLNAAACLG--SPSIVALLSEDPADILTADSL 207

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217276170  146 GNTALHYAVYNEDISVATK---------LLLYDANI-------EAKNKDDLTPLLLAVSGKKQQMVEFLIKKK 202
Cdd:TIGR00870  208 GNTLLHLLVMENEFKAEYEelscqmynfALSLLDKLrdskeleVILNHQGLTPLKLAAKEGRIVLFRLKLAIK 280
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 751-982 1.38e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 49.38  E-value: 1.38e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  751 ERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYrkevevkQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQ 830
Cdd:COG4942     26 EAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRI-------AALARRIRALEQELAALEAELAELEKEIAELRAE 98

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  831 LSREQN--ARMLQDgiltnhLSKQKEIEMAQKKMNSENSHSHEEEKD-LSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKK 907
Cdd:COG4942     99 LEAQKEelAELLRA------LYRLGRQPPLALLLSPEDFLDAVRRLQyLKYLAPARREQAEELRADLAELAALRAELEAE 172

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2217276170  908 cFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAA 982
Cdd:COG4942    173 -RAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPAA 246
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 41-209 1.39e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 49.58  E-value: 1.39e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170   41 HVRDRDLGK-IHKAASAGNVAKVQQILLLRKNgLNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMK 119
Cdd:PHA02874   118 NIKDAELKTfLHYAIKKGDLESIKMLFEYGAD-VNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHN 196

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  120 AVQCQEEKCATILLEHGADPNLADVHGNTALHYAV-YNEDisvATKLLLYDANIEAKNKDDLTPLLLAVSGK-KQQMVEF 197
Cdd:PHA02874   197 AAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIiHNRS---AIELLINNASINDQDIDGSTPLHHAINPPcDIDIIDI 273

                          170
                   ....*....|..
gi 2217276170  198 LIKKKANVNAVD 209
Cdd:PHA02874   274 LLYHKADISIKD 285
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1227-1561 1.47e-05

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 50.06  E-value: 1.47e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1227 KKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNAnlsEDEKEQLKKLMELKQ 1306
Cdd:PRK03918   165 KNLGEVIKEIKRRIERLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREELEKL---EKEVKELEELKEEIE 241

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1307 SLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEfsfhGDLKTSQFEMD--IQINKLKHKIDDLTAELETAGS 1384
Cdd:PRK03918   242 ELEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKV----KELKELKEKAEeyIKLSEFYEEYLDELREIEKRLS 317

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1385 KclhLDTKNQILQEELLSMKTVQKKCEKLQKNKKKLEQEVINLRSHI---ERNMVELGQVKQYKQEIEERARQEIAEKLK 1461
Cdd:PRK03918   318 R---LEEEINGIEERIKELEEKEERLEELKKKLKELEKRLEELEERHelyEEAKAKKEELERLKKRLTGLTPEKLEKELE 394

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1462 EVNlflQAQAASQENLEQFREnnfasMKSQMELRIKDLESELSKIKTSQ-----------EDFNKTELEKYKQLYLEELK 1530
Cdd:PRK03918   395 ELE---KAKEEIEEEISKITA-----RIGELKKEIKELKKAIEELKKAKgkcpvcgreltEEHRKELLEEYTAELKRIEK 466

                          330       340       350
                   ....*....|....*....|....*....|.
gi 2217276170 1531 VRKSLSSKLTKTNERLAEVNTKLLVEKQQSR 1561
Cdd:PRK03918   467 ELKEIEEKERKLRKELRELEKVLKKESELIK 497
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 709-935 1.50e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 50.06  E-value: 1.50e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  709 KNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQ 788
Cdd:TIGR02168  795 KEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESE 874

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  789 YRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLS--REQNARM-LQDGILTNHLSKQKEIEMAQKKMNSE 865
Cdd:TIGR02168  875 LEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEelREKLAQLeLRLEGLEVRIDNLQERLSEEYSLTLE 954

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217276170  866 NSHSHEEEKDLSHKNsmLQEEIAMLRLEIDTIKNQNQ------EKEKKCFEDLkivKEKNEDLQKTIKQNEETLTQ 935
Cdd:TIGR02168  955 EAEALENKIEDDEEE--ARRRLKRLENKIKELGPVNLaaieeyEELKERYDFL---TAQKEDLTEAKETLEEAIEE 1025
HCR pfam07111
Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha ...
 780-1324 1.53e-05

Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha helical coiled-coil rod HCR proteins. The function of HCR is unknown but it has been implicated in psoriasis in humans and is thought to affect keratinocyte proliferation.


Pssm-ID: 284517 [Multi-domain]  Cd Length: 749  Bit Score: 49.75  E-value: 1.53e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  780 EQLRRKEEQYR--KEVEVKQQLELSLQTLEME---------------LRT-------VKSNLNQVVQERNDAQRQLSREQ 835
Cdd:pfam07111   73 QELRRLEEEVRllRETSLQQKMRLEAQAMELDalavaekagqaeaegLRAalagaemVRKNLEEGSQRELEEIQRLHQEQ 152

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  836 NARMLQ--DGILTNHLSKQKEIEmaqKKMNSENSHSHEEEKDLshknSMLQEEIAMLRLEIDTIKnQNQEKEKKCFEDLK 913
Cdd:pfam07111  153 LSSLTQahEEALSSLTSKAEGLE---KSLNSLETKRAGEAKQL----AEAQKEAELLRKQLSKTQ-EELEAQVTLVESLR 224

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  914 -----------------IVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAE----- 971
Cdd:pfam07111  225 kyvgeqvppevhsqtweLERQELLDTMQHLQEDRADLQATVELLQVRVQSLTHMLALQEEELTRKIQPSDSLEPEfpkkc 304

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  972 ---VESYHSRLAAAIHDRDQSETSKRElelAFQRARDECSRLQDKmnfdVSNLKDNNEILSQQLFKTESKL-------NS 1041
Cdd:pfam07111  305 rslLNRWREKVFALMVQLKAQDLEHRD---SVKQLRGQVAELQEQ----VTSQSQEQAILQRALQDKAAEVevermsaKG 377

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1042 LEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQlqsenmllrqqlddahn 1121
Cdd:pfam07111  378 LQMELSRAQEARRRQQQQTASAEEQLKFVVNAMSSTQIWLETTMTRVEQAVARIPSLSNRLSY----------------- 440

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1122 kADNKEKTVINIQDQFHAIVQkLQAESEKQSLLLEERNKELISECNHLKERQYQYEnekAEREVVVRQLQQELAdtlKKQ 1201
Cdd:pfam07111  441 -AVRKVHTIKGLMARKVALAQ-LRQESCPPPPPAPPVDADLSLELEQLREERNRLD---AELQLSAHLIQQEVG---RAR 512

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1202 SMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCA--------EKMQDHKQKLEKDNAKLKVTVKK 1273
Cdd:pfam07111  513 EQGEAERQQLSEVAQQLEQELQRAQESLASVGQQLEVARQGQQESTEEAaslrqeltQQQEIYGQALQEKVAEVETRLRE 592

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2217276170 1274 QMDKIEElqknllnaNLSEDEKEQLKKLMELKQsLECNLDQEMKKNVELER 1324
Cdd:pfam07111  593 QLSDTKR--------RLNEARREQAKAVVSLRQ-IQHRATQEKERNQELRR 634
Ank_4 pfam13637
Ankyrin repeats (many copies);
146-199 1.59e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 43.80  E-value: 1.59e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2217276170  146 GNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLI 199
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 730-1432 1.62e-05

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 49.63  E-value: 1.62e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  730 QRELSETKEIKSQLEHQkvewERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEME 809
Cdd:TIGR04523   36 KQLEKKLKTIKNELKNK----EKELKNLDKNLNKDEEKINNSNNKIKILEQQIKDLNDKLKKNKDKINKLNSDLSKINSE 111

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  810 LRTVKSNLNQVVQERNDAQRQLsreQNARMLQDGILTNHLSKQKEIEmaqkKMNSENSHSHEEEKDLSHKNSMLQEEIAM 889
Cdd:TIGR04523  112 IKNDKEQKNKLEVELNKLEKQK---KENKKNIDKFLTEIKKKEKELE----KLNNKYNDLKKQKEELENELNLLEKEKLN 184

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  890 LRLEIDTIKNQNQEKEKKCFeDLKIVKEKNEDLQKTI---KQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKE 966
Cdd:TIGR04523  185 IQKNIDKIKNKLLKLELLLS-NLKKKIQKNKSLESQIselKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQN 263

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  967 RLEaevesyhSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLkdnneiLSQQLFKTESKLNSLEIEF 1046
Cdd:TIGR04523  264 KIK-------KQLSEKQKELEQNNKKIKELEKQLNQLKSEISDLNNQKEQDWNKE------LKSELKNQEKKLEEIQNQI 330

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1047 HHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNK 1126
Cdd:TIGR04523  331 SQNNKIISQLNEQISQLKKELTNSESENSEKQRELEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLNQQK 410

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1127 EKTVINIQDQFHAIVQKLQAESEKQSLL------LEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKK 1200
Cdd:TIGR04523  411 DEQIKKLQQEKELLEKEIERLKETIIKNnseikdLTNQDSVKELIIKNLDNTRESLETQLKVLSRSINKIKQNLEQKQKE 490

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1201 QSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKL--EKDNAKLKVTVKKQMDKI 1278
Cdd:TIGR04523  491 LKSKEKELKKLNEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEKESKISDLEDELNKDdfELKKENLEKEIDEKNKEI 570

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1279 EEL---QKNLLNANLS--------EDEKEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGE 1347
Cdd:TIGR04523  571 EELkqtQKSLKKKQEEkqelidqkEKEKKDLIKEIEEKEKKISSLEKELEKAKKENEKLSSIIKNIKSKKNKLKQEVKQI 650

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1348 FSFHGDLKTSQFEMDIQINKLKHKIDDLTAELETAGSKCLHLDTKNQILQEELLSMKTVQKKCEKLQKNKKKLEQEVINL 1427
Cdd:TIGR04523  651 KETIKEIRNKWPEIIKKIKESKTKIDDIIELMKDWLKELSLHYKKYITRMIRIKDLPKLEEKYKEIEKELKKLDEFSKEL 730


                   ....*
gi 2217276170 1428 RSHIE 1432
Cdd:TIGR04523  731 ENIIK 735
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 51-179 2.03e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 49.51  E-value: 2.03e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170   51 HKAASAGNVAKvqQILLLRKNGLNDRDKMNRTALHLACANGHPEVVTLlvdrkcqlnvcdnenrtalmkavqcqeekcat 130
Cdd:PTZ00322    88 QLAASGDAVGA--RILLTGGADPNCRDYDGRTPLHIACANGHVQVVRV-------------------------------- 133

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2217276170  131 iLLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLY---DANIEAKNKDD 179
Cdd:PTZ00322   134 -LLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHsqcHFELGANAKPD 184
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 678-1386 4.13e-05

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 48.58  E-value: 4.13e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  678 IEQLGMECKDSVSLLkIQDAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQrelSETKEIKSQLEHQKVEWERELCSL 757
Cdd:pfam15921  247 LEALKSESQNKIELL-LQQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQ---SQLEIIQEQARNQNSMYMRQLSDL 322

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  758 RFSLNQEEEKRRNADTLYEKIREQLRRK----EEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNqvvqeRNDAQRQLSR 833
Cdd:pfam15921  323 ESTVSQLRSELREAKRMYEDKIEELEKQlvlaNSELTEARTERDQFSQESGNLDDQLQKLLADLH-----KREKELSLEK 397

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  834 EQNARM----LQDGILTNHLSKQ--------KEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKnqn 901
Cdd:pfam15921  398 EQNKRLwdrdTGNSITIDHLRRElddrnmevQRLEALLKAMKSECQGQMERQMAAIQGKNESLEKVSSLTAQLESTK--- 474

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  902 qEKEKKCFEDLKIVKEKNEDLQKTIKQneetLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAE------VESY 975
Cdd:pfam15921  475 -EMLRKVVEELTAKKMTLESSERTVSD----LTASLQEKERAIEATNAEITKLRSRVDLKLQELQHLKNEgdhlrnVQTE 549

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  976 HSRLAAAIHDRDQS-ETSKRELE----LAFQRARD------ECSRLQDKMN---FDVSNLKDNNEILSQQLFKTESKLNS 1041
Cdd:pfam15921  550 CEALKLQMAEKDKViEILRQQIEnmtqLVGQHGRTagamqvEKAQLEKEINdrrLELQEFKILKDKKDAKIRELEARVSD 629

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1042 LEIEFHHTRDALREKTlgleRVQKDLSQTQCQMKEMEQKYQNEQVKVNK-YIGKQESVEERLSQLQSENMLLRQQLDDAH 1120
Cdd:pfam15921  630 LELEKVKLVNAGSERL----RAVKDIKQERDQLLNEVKTSRNELNSLSEdYEVLKRNFRNKSEEMETTTNKLKMQLKSAQ 705

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1121 NKADNKEKTVINIQ-DQFHAIvqKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLK 1199
Cdd:pfam15921  706 SELEQTRNTLKSMEgSDGHAM--KVAMGMQKQITAKRGQIDALQSKIQFLEEAMTNANKEKHFLKEEKNKLSQELSTVAT 783

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1200 KQSMSEASLEVtsryrinLEDETQDLKKKLGQIRNQLQEAQDRHTEAvrcaekmQDHKQKLEKDNAKLKVtvkKQMDKIE 1279
Cdd:pfam15921  784 EKNKMAGELEV-------LRSQERRLKEKVANMEVALDKASLQFAEC-------QDIIQRQEQESVRLKL---QHTLDVK 846

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1280 ELQKNLLNAN-------LSEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREIT-GFKNLLKMTRKKLNEYENGEFSfh 1351
Cdd:pfam15921  847 ELQGPGYTSNssmkprlLQPASFTRTHSNVPSSQSTASFLSHHSRKTNALKEDPTrDLKQLLQELRSVINEEPTVQLS-- 924

                          730       740       750
                   ....*....|....*....|....*....|....*
gi 2217276170 1352 gdlKTSQFEMDIQINKLKHKIDDLTAELETAGSKC 1386
Cdd:pfam15921  925 ---KAEDKGRAPSLGALDDRVRDCIIESSLRSDIC 956
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 718-1309 4.38e-05

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 48.48  E-value: 4.38e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  718 KIKKMEDKVNVLQRELSETKEIKSQLehqkvewERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQ 797
Cdd:TIGR04523   97 KINKLNSDLSKINSEIKNDKEQKNKL-------EVELNKLEKQKKENKKNIDKFLTEIKKKEKELEKLNNKYNDLKKQKE 169

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  798 QLELSLQTLEMELRTVKSNLNQVVQERNdaqrqlsreqnarmlqdgILTNHLSKQKEIEMAQKKMNSENSHSHEEEKDLS 877
Cdd:TIGR04523  170 ELENELNLLEKEKLNIQKNIDKIKNKLL------------------KLELLLSNLKKKIQKNKSLESQISELKKQNNQLK 231

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  878 HKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEEtLTQTISQYNGRLSVLTAE-----NA 952
Cdd:TIGR04523  232 DNIEKKQQEINEKTTEISNTQTQLNQLKDEQNKIKKQLSEKQKELEQNNKKIKE-LEKQLNQLKSEISDLNNQkeqdwNK 310

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  953 MLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKmnfdVSNLKDNNEILSQQL 1032
Cdd:TIGR04523  311 ELKSELKNQEKKLEEIQNQISQNNKIISQLNEQISQLKKELTNSESENSEKQRELEEKQNE----IEKLKKENQSYKQEI 386

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1033 FKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLL 1112
Cdd:TIGR04523  387 KNLESQINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESL 466

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1113 RQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSlLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQ 1192
Cdd:TIGR04523  467 ETQLKVLSRSINKIKQNLEQKQKELKSKEKELKKLNEEKK-ELEEKVKDLTKKISSLKEKIEKLESEKKEKESKISDLED 545

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1193 EL---ADTLKKQsmseaslevtsryriNLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKV 1269
Cdd:TIGR04523  546 ELnkdDFELKKE---------------NLEKEIDEKNKEIEELKQTQKSLKKKQEEKQELIDQKEKEKKDLIKEIEEKEK 610

                          570       580       590       600
                   ....*....|....*....|....*....|....*....|
gi 2217276170 1270 TVKKQMDKIEELQKNllNANLSEDEKEQLKKLMELKQSLE 1309
Cdd:TIGR04523  611 KISSLEKELEKAKKE--NEKLSSIIKNIKSKKNKLKQEVK 648
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
 1269-1543 5.62e-05

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 48.00  E-value: 5.62e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1269 VTVKKQMDK-IEELQKnlLNA----NLSEDEK-EQLKKLMELKQSLECNLDQeMKKNVELEReiTGFKNLLKMTRKKLNE 1342
Cdd:PRK05771    12 VTLKSYKDEvLEALHE--LGVvhieDLKEELSnERLRKLRSLLTKLSEALDK-LRSYLPKLN--PLREEKKKVSVKSLEE 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1343 YENGEFSFHGDLKTSQFEMDIQINKLKHKIDDLTAELETAgSKCLHLDtknqILQEELLSMKTVQKKCEKLQKNKKKLEQ 1422
Cdd:PRK05771    87 LIKDVEEELEKIEKEIKELEEEISELENEIKELEQEIERL-EPWGNFD----LDLSLLLGFKYVSVFVGTVPEDKLEELK 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1423 EVINLRSHIErnmvelgqVKQYKQE------IEERARQEIAEKLKEVNLflqaqaasqENLEQFRENNFASMKSQMELRI 1496
Cdd:PRK05771   162 LESDVENVEY--------ISTDKGYvyvvvvVLKELSDEVEEELKKLGF---------ERLELEEEGTPSELIREIKEEL 224

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1497 KDLESELSKIKTSQEDFNKtELEKYKQLYLEEL---KVRKSLSSKLTKTN 1543
Cdd:PRK05771   225 EEIEKERESLLEELKELAK-KYLEELLALYEYLeieLERAEALSKFLKTD 273
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
780-1264 6.03e-05

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 47.84  E-value: 6.03e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  780 EQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDgiLTNHL-SKQKEIEMA 858
Cdd:COG4717     74 KELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQLLPLYQELEA--LEAELaELPERLEEL 151

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  859 QKKMnsenshshEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLkivKEKNEDLQKTIKQNEETLTQTIS 938
Cdd:COG4717    152 EERL--------EELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDL---AEELEELQQRLAELEEELEEAQE 220

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  939 QYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESyhSRLAAAIHDRDQSETSKRELELAFQRA--------RDECSRL 1010
Cdd:COG4717    221 ELEELEEELEQLENELEAAALEERLKEARLLLLIAA--ALLALLGLGGSLLSLILTIAGVLFLVLgllallflLLAREKA 298

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1011 QDKMNFDVSNLKDNNEILSQQlfKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNK 1090
Cdd:COG4717    299 SLGKEAEELQALPALEELEEE--ELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEELQLEELEQEIAALL 376

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1091 YIGKQESVEErlsqlqsenmlLRQQLdDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLlleernkelisecNHLK 1170
Cdd:COG4717    377 AEAGVEDEEE-----------LRAAL-EQAEEYQELKEELEELEEQLEELLGELEELLEALDE-------------EELE 431

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1171 ERQYQYENEKAEREVVVRQLQQELADTlkkqsmsEASLEVTSRyrinlEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCA 1250
Cdd:COG4717    432 EELEELEEELEELEEELEELREELAEL-------EAELEQLEE-----DGELAELLQELEELKAELRELAEEWAALKLAL 499

                          490
                   ....*....|....
gi 2217276170 1251 EKMQDHKQKLEKDN 1264
Cdd:COG4717    500 ELLEEAREEYREER 513
PTZ00121 PTZ00121
MAEBL; Provisional
 703-1398 9.03e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 47.44  E-value: 9.03e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  703 RLLELKKNHCELLTVKIKKMEDkVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYekiREQL 782
Cdd:PTZ00121  1213 KAEEARKAEDAKKAEAVKKAEE-AKKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELK---KAEE 1288

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  783 RRKEEQYRKEVEVKQQLELSLQTleMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQKKM 862
Cdd:PTZ00121  1289 KKKADEAKKAEEKKKADEAKKKA--EEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKA 1366

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  863 NSENSHSHEEEKDLSHKNSMLQEeiamlRLEIDTIKNQNQEKEKKCfEDLKIVKEKNEDLQKTIKQNEEtltqtisqyng 942
Cdd:PTZ00121  1367 EAAEKKKEEAKKKADAAKKKAEE-----KKKADEAKKKAEEDKKKA-DELKKAAAAKKKADEAKKKAEE----------- 1429

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  943 rlsVLTAENAmlNSKLENEKQSKE-RLEAEVESYHSRLAAAIHDRDQSETSKRELELAfqRARDECSRLQDKMNFDVSNL 1021
Cdd:PTZ00121  1430 ---KKKADEA--KKKAEEAKKADEaKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEA--KKADEAKKKAEEAKKKADEA 1502

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1022 KDnneilsqqlfKTESKLNSLEIEFHHTRDALREKTLGLERVQKDlsqtqcQMKEMEQKYQNEQVKVNKYIGKQES---V 1098
Cdd:PTZ00121  1503 KK----------AAEAKKKADEAKKAEEAKKADEAKKAEEAKKAD------EAKKAEEKKKADELKKAEELKKAEEkkkA 1566

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1099 EERLSQLQSENMLLRQQlddahNKADNKEKTVINIQDQFHAIVQKLQAESEKQSllLEERNK-ELISECNHLKERQYQYE 1177
Cdd:PTZ00121  1567 EEAKKAEEDKNMALRKA-----EEAKKAEEARIEEVMKLYEEEKKMKAEEAKKA--EEAKIKaEELKKAEEEKKKVEQLK 1639

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1178 NEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAqdRHTEAVRCAEKMQDHK 1257
Cdd:PTZ00121  1640 KKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEA--KKAEELKKKEAEEKKK 1717

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1258 -QKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMT 1336
Cdd:PTZ00121  1718 aEELKKAEEENKIKAEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVD 1797

                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2217276170 1337 RKKLNEYENGEFSFHGDLKTSQFemdiqINKLKHKIDDLTAELetagskclhLDTKNQILQE 1398
Cdd:PTZ00121  1798 KKIKDIFDNFANIIEGGKEGNLV-----INDSKEMEDSAIKEV---------ADSKNMQLEE 1845
Ank_5 pfam13857
Ankyrin repeats (many copies);
98-153 1.25e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 41.18  E-value: 1.25e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2217276170   98 LLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPNLADVHGNTALHYA 153
Cdd:pfam13857    1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1188-1400 1.45e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 45.91  E-value: 1.45e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1188 RQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKL 1267
Cdd:COG4942     23 AEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQ 102

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1268 KVTVKKQMDKIEEL-QKNLLNANLSEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENG 1346
Cdd:COG4942    103 KEELAELLRALYRLgRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELEALLAE 182

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2217276170 1347 EFSFHGDLKTSQFEMDIQINKLKHKIDDLTAELETAGSKCLHLDTKNQILQEEL 1400
Cdd:COG4942    183 LEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEA 236
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 81-202 1.80e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 46.03  E-value: 1.80e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170   81 RTALHLACANGHPEVVTLLVDRKC--QLNVCDNENRTA-----------LMKAVQCQEEKCATILLEHGADP---NLADV 144
Cdd:cd21882     74 QTALHIAIENRNLNLVRLLVENGAdvSARATGRFFRKSpgnlfyfgelpLSLAACTNQEEIVRLLLENGAQPaalEAQDS 153

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217276170  145 HGNTALHYAVYNED---------ISVATKLLLYDANI-------EAKNKDDLTPLLLAVSGKKQQMVEFLIKKK 202
Cdd:cd21882    154 LGNTVLHALVLQADntpensafvCQMYNLLLSYGAHLdptqqleEIPNHQGLTPLKLAAVEGKIVMFQHILQRE 227
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 81-111 1.87e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 39.97  E-value: 1.87e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2217276170   81 RTALHLACA-NGHPEVVTLLVDRKCQLNVCDN 111
Cdd:pfam00023    3 NTPLHLAAGrRGNLEIVKLLLSKGADVNARDK 34
PRK11281 PRK11281
mechanosensitive channel MscK;
915-1119 1.88e-04

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 46.44  E-value: 1.88e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  915 VKEKNEDLQKTIKQneetLTQTISQYNGRLSVLTAEN-------------AMLNSKLENEKQSKERLEAEVESYHSRLAA 981
Cdd:PRK11281    78 QKEETEQLKQQLAQ----APAKLRQAQAELEALKDDNdeetretlstlslRQLESRLAQTLDQLQNAQNDLAEYNSQLVS 153

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  982 AihdRDQSETSKRELELAFQRArdecsrlqDKMNFDVSNLKDNNEILS---QQLFKTESKLNSLEIEFHHT--------- 1049
Cdd:PRK11281   154 L---QTQPERAQAALYANSQRL--------QQIRNLLKGGKVGGKALRpsqRVLLQAEQALLNAQNDLQRKslegntqlq 222

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1050 ------RDALREKTLGLERV---------QKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQ---------- 1104
Cdd:PRK11281   223 dllqkqRDYLTARIQRLEHQlqllqeainSKRLTLSEKTVQEAQSQDEAARIQANPLVAQELEINLQLSQrllkatekln 302

                          250
                   ....*....|....*.
gi 2217276170 1105 -LQSENMLLRQQLDDA 1119
Cdd:PRK11281   303 tLTQQNLRVKNWLDRL 318
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1360-1533 1.99e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 44.92  E-value: 1.99e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1360 EMDIQINKLKHKIDDLTAELEtagskclHLDTKNQILQEELlsmKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELG 1439
Cdd:COG1579     14 ELDSELDRLEHRLKELPAELA-------ELEDELAALEARL---EAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLG 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1440 QVKQYKQ------EIE--ERARQEIAEKLKEVNLFLQAQAASQENLEQF---RENNFASMKSQMELRIKDLESELSKIKT 1508
Cdd:COG1579     84 NVRNNKEyealqkEIEslKRRISDLEDEILELMERIEELEEELAELEAElaeLEAELEEKKAELDEELAELEAELEELEA 163

                          170       180
                   ....*....|....*....|....*
gi 2217276170 1509 SQEDFNKTELEKYKQLYlEELKVRK 1533
Cdd:COG1579    164 EREELAAKIPPELLALY-ERIRKRK 187
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 1201-1575 2.05e-04

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 46.27  E-value: 2.05e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1201 QSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVrcaEKMQDHKQKLEKDNAKLKVTVKKQMDKIEE 1280
Cdd:pfam17380  247 EDVTTMTPEYTVRYNGQTMTENEFLNQLLHIVQHQKAVSERQQQEKF---EKMEQERLRQEKEEKAREVERRRKLEEAEK 323

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1281 LQKNLLN---ANLSEDEKEQLKKLMELKQSLECNLDQEMK--KNVELEREITGFKNL--LKMTRKKLNEYENGEFSFHGD 1353
Cdd:pfam17380  324 ARQAEMDrqaAIYAEQERMAMERERELERIRQEERKRELEriRQEEIAMEISRMRELerLQMERQQKNERVRQELEAARK 403

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1354 LKTSQFEMDIQINKLKHKIDDLTAELETAGSKCLhldtknQILQEELlsmktvQKKCEKLQKNKKKLEQEVINLRSHIE- 1432
Cdd:pfam17380  404 VKILEEERQRKIQQQKVEMEQIRAEQEEARQREV------RRLEEER------AREMERVRLEEQERQQQVERLRQQEEe 471

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1433 --RNMVELGQVKQYKQEIEERARQEIAEKLKEvnlflQAQAASQEnleqfrENNFASMKSQMELRIKDLESELSKIKTSQ 1510
Cdd:pfam17380  472 rkRKKLELEKEKRDRKRAEEQRRKILEKELEE-----RKQAMIEE------ERKRKLLEKEMEERQKAIYEEERRREAEE 540

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217276170 1511 EDFNKTELEKYKQLYLEELKVRKSLSSKLTKTNERLAEVNTKLLVEKQQSRSLFTTLTT-RPVMEP 1575
Cdd:pfam17380  541 ERRKQQEMEERRRIQEQMRKATEERSRLEAMEREREMMRQIVESEKARAEYEATTPITTiKPIYRP 606
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1079-1342 2.39e-04

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 45.78  E-value: 2.39e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1079 QKYQNEQVKVnkyigKQESVEERLSQLQSENMLLRQQLDDAHNKadnkektviniqdqfhaiVQKLQAESekQSLLLEER 1158
Cdd:COG3206    159 EAYLEQNLEL-----RREEARKALEFLEEQLPELRKELEEAEAA------------------LEEFRQKN--GLVDLSEE 213

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1159 NKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVtsryrinledetQDLKKKLGQIRNQLQE 1238
Cdd:COG3206    214 AKLLLQQLSELESQLAEARAELAEAEARLAALRAQLGSGPDALPELLQSPVI------------QQLRAQLAELEAELAE 281

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1239 AQ----DRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEElQKNLLNANLsEDEKEQLKKLMELKQSLEcnldq 1314
Cdd:COG3206    282 LSarytPNHPDVIALRAQIAALRAQLQQEAQRILASLEAELEALQA-REASLQAQL-AQLEARLAELPELEAELR----- 354

                          250       260
                   ....*....|....*....|....*...
gi 2217276170 1315 emkknvELEREITGFKNLLKMTRKKLNE 1342
Cdd:COG3206    355 ------RLEREVEVARELYESLLQRLEE 376
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 693-974 3.44e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 45.43  E-value: 3.44e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  693 KIQDAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNAD 772
Cdd:TIGR02168  716 QLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLK 795

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  773 TLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSR--------EQNARMLQDGI 844
Cdd:TIGR02168  796 EELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESlaaeieelEELIEELESEL 875

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  845 ltNHLSKQK------------EIEMAQKKMNSENSHSHEEEKDLSHKNSML---QEEIAMLRLEIDTIKNQNQEKEKKCF 909
Cdd:TIGR02168  876 --EALLNERasleealallrsELEELSEELRELESKRSELRRELEELREKLaqlELRLEGLEVRIDNLQERLSEEYSLTL 953

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2217276170  910 EDLKIVKEKNEDLQKTIKQNEETLTQTI--------------SQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVES 974
Cdd:TIGR02168  954 EEAEALENKIEDDEEEARRRLKRLENKIkelgpvnlaaieeyEELKERYDFLTAQKEDLTEAKETLEEAIEEIDREARE 1032
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 988-1533 3.49e-04

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 45.12  E-value: 3.49e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  988 QSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDL 1067
Cdd:pfam05557   13 QLQNEKKQMELEHKRARIELEKKASALKRQLDRESDRNQELQKRIRLLEKREAEAEEALREQAELNRLKKKYLEALNKKL 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1068 SQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQfhaivQKLQAE 1147
Cdd:pfam05557   93 NEKESQLADAREVISCLKNELSELRRQIQRAELELQSTNSELEELQERLDLLKAKASEAEQLRQNLEKQ-----QSSLAE 167

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1148 SEKQSLLLEERNKelisecnhlkerqyQYENEKAerevVVRQLQQELADTLKKQSMSEASLEVTSRYRIN------LEDE 1221
Cdd:pfam05557  168 AEQRIKELEFEIQ--------------SQEQDSE----IVKNSKSELARIPELEKELERLREHNKHLNENienkllLKEE 229

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1222 TQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKqKLEKDNAKLKVTVKKQMDKIEELQ---------KNLLNANLSE 1292
Cdd:pfam05557  230 VEDLKRKLEREEKYREEAATLELEKEKLEQELQSWV-KLAQDTGLNLRSPEDLSRRIEQLQqreivlkeeNSSLTSSARQ 308

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1293 DEKEQLKKLMELKQSLECNLDQEM-------------KKNVELEREITGFKNLLKMTRKKLNEYENGEfsfhgDLKTSQF 1359
Cdd:pfam05557  309 LEKARRELEQELAQYLKKIEDLNKklkrhkalvrrlqRRVLLLTKERDGYRAILESYDKELTMSNYSP-----QLLERIE 383

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1360 EMDIQINKLKHKIDDLTAELETAGSKCLHLDTKNQILQEELLSMKTvqkkcEKLQKNKKKLEQEVINLRSHIERNMVELG 1439
Cdd:pfam05557  384 EAEDMTQKMQAHNEEMEAQLSVAEEELGGYKQQAQTLERELQALRQ-----QESLADPSYSKEEVDSLRRKLETLELERQ 458

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1440 QVKQYKQEIE-ERARQEIAEKLKEV---------NLFLQAQAASQENLEQFRENNfASMKSQMELRIKDLESELSKIKTS 1509
Cdd:pfam05557  459 RLREQKNELEmELERRCLQGDYDPKktkvlhlsmNPAAEAYQQRKNQLEKLQAEI-ERLKRLLKKLEDDLEQVLRLPETT 537

                          570       580
                   ....*....|....*....|....
gi 2217276170 1510 QEDFNKTELEKYKQLYLEELKVRK 1533
Cdd:pfam05557  538 STMNFKEVLDLRKELESAELKNQR 561
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
 1364-1524 5.20e-04

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 44.82  E-value: 5.20e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1364 QINKLKHKIDDLTAELEtagSKCLHLDTKNQILQEELlsmKTVQKKCEKLQKNKKKLEQEVINLRSHIErnmvelgqvKQ 1443
Cdd:PRK00409   510 LIGEDKEKLNELIASLE---ELERELEQKAEEAEALL---KEAEKLKEELEEKKEKLQEEEDKLLEEAE---------KE 574

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1444 YKQEIEErARQEIAEKLKEVNLFLQAQAASQenleqfRENNFASMKSQMELRIKDLESELSKIKTSQEDFNKTELEKYKQ 1523
Cdd:PRK00409   575 AQQAIKE-AKKEADEIIKELRQLQKGGYASV------KAHELIEARKRLNKANEKKEKKKKKQKEKQEELKVGDEVKYLS 647


                   .
gi 2217276170 1524 L 1524
Cdd:PRK00409   648 L 648
PRK12704 PRK12704
phosphodiesterase; Provisional
 1175-1303 6.00e-04

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 44.38  E-value: 6.00e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1175 QYENEKAEREVVVRQLQQElADTLKKQSMSEASLEVtSRYRINLEDETQDLKKKLGQIRNQLQ---EAQDRHTEAVrcaE 1251
Cdd:PRK12704    32 KIKEAEEEAKRILEEAKKE-AEAIKKEALLEAKEEI-HKLRNEFEKELRERRNELQKLEKRLLqkeENLDRKLELL---E 106

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2217276170 1252 KMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLN-----ANLSEDE-KEQLKKLME 1303
Cdd:PRK12704   107 KREEELEKKEKELEQKQQELEKKEEELEELIEEQLQeleriSGLTAEEaKEILLEKVE 164
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 1096-1567 6.50e-04

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 44.78  E-value: 6.50e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1096 ESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQdqfhaiVQKLQAES-----EKQSLLLEERNKELISECNHLK 1170
Cdd:pfam01576   85 EEEEERSQQLQNEKKKMQQHIQDLEEQLDEEEAARQKLQ------LEKVTTEAkikklEEDILLLEDQNSKLSKERKLLE 158

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1171 ERQYQYENEKAEREVVVRQLQQ----------ELADTLKKQSMSEASLEVTSRY----RINLEDETQDLKKKLGQIRNQL 1236
Cdd:pfam01576  159 ERISEFTSNLAEEEEKAKSLSKlknkheamisDLEERLKKEEKGRQELEKAKRKlegeSTDLQEQIAELQAQIAELRAQL 238

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1237 QEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLkvtvkkqMDKIEELQKNLLNANLSEDEKEQLKKlmELKQSLECnldqeM 1316
Cdd:pfam01576  239 AKKEEELQAALARLEEETAQKNNALKKIREL-------EAQISELQEDLESERAARNKAEKQRR--DLGEELEA-----L 304

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1317 KKNVELEREITGFKNLLKMTRkklnEYENGEFSFHGDLKTSQFEMDIQINKLKH--KIDDLTAELETAGSKCLHLDTKNQ 1394
Cdd:pfam01576  305 KTELEDTLDTTAAQQELRSKR----EQEVTELKKALEEETRSHEAQLQEMRQKHtqALEELTEQLEQAKRNKANLEKAKQ 380

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1395 ILQEELLS----MKTVQKKCEKLQKNKKKLEQEVINLRSHI---ERNMVELG---------------------------- 1439
Cdd:pfam01576  381 ALESENAElqaeLRTLQQAKQDSEHKRKKLEGQLQELQARLsesERQRAELAeklsklqselesvssllneaegknikls 460

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1440 ----QVKQYKQEIEERARQEIAEKLKEVNLFLQAQAASQENLEQFRENNFAsmKSQMELRIKDLESELSKIKTSQEDFNK 1515
Cdd:pfam01576  461 kdvsSLESQLQDTQELLQEETRQKLNLSTRLRQLEDERNSLQEQLEEEEEA--KRNVERQLSTLQAQLSDMKKKLEEDAG 538

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217276170 1516 T-----ELEKYKQLYLEELKVR----KSLSSKLTKTNERLAEVNTKLLVEKQQSRSLFTTL 1567
Cdd:pfam01576  539 TlealeEGKKRLQRELEALTQQleekAAAYDKLEKTKNRLQQELDDLLVDLDHQRQLVSNL 599
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 80-108 7.31e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 38.39  E-value: 7.31e-04
                           10        20
                   ....*....|....*....|....*....
gi 2217276170   80 NRTALHLACANGHPEVVTLLVDRKCQLNV 108
Cdd:pfam13606    2 GNTPLHLAARNGRLEIVKLLLENGADINA 30
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 79-108 8.37e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 38.34  E-value: 8.37e-04
                            10        20        30
                    ....*....|....*....|....*....|
gi 2217276170    79 MNRTALHLACANGHPEVVTLLVDRKCQLNV 108
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
PRK10929 PRK10929
putative mechanosensitive channel protein; Provisional
 724-950 1.26e-03

putative mechanosensitive channel protein; Provisional


Pssm-ID: 236798 [Multi-domain]  Cd Length: 1109  Bit Score: 43.50  E-value: 1.26e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  724 DKVNVLQRELSETKEIKSQLE----HQKV--EWERELCSLRFSLNQEEEKRRNadtlyekIREQLRRKE-EQyrKEVEVK 796
Cdd:PRK10929    45 EIVEALQSALNWLEERKGSLErakqYQQVidNFPKLSAELRQQLNNERDEPRS-------VPPNMSTDAlEQ--EILQVS 115

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  797 QQL-ELS--LQTLEMELRTVKSNLNQVVQERNDAQRQLSreQNARMLQdgILTNHLSKQKEIEMAQKKMNSENSHSHEEE 873
Cdd:PRK10929   116 SQLlEKSrqAQQEQDRAREISDSLSQLPQQQTEARRQLN--EIERRLQ--TLGTPNTPLAQAQLTALQAESAALKALVDE 191

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  874 KDLSHKNSMLQEEIAMLRLEI----------------DTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTI----KQNEEtL 933
Cdd:PRK10929   192 LELAQLSANNRQELARLRSELakkrsqqldaylqalrNQLNSQRQREAERALESTELLAEQSGDLPKSIvaqfKINRE-L 270

                          250
                   ....*....|....*..
gi 2217276170  934 TQTISQYNGRLSVLTAE 950
Cdd:PRK10929   271 SQALNQQAQRMDLIASQ 287
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 145-177 1.34e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 37.65  E-value: 1.34e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 2217276170  145 HGNTALHYAVYNE-DISVATKLLLYDANIEAKNK 177
Cdd:pfam00023    1 DGNTPLHLAAGRRgNLEIVKLLLSKGADVNARDK 34
PHA02736 PHA02736
Viral ankyrin protein; Provisional
 75-203 1.40e-03

Viral ankyrin protein; Provisional


Pssm-ID: 165103 [Multi-domain]  Cd Length: 154  Bit Score: 41.02  E-value: 1.40e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170   75 DRDKMNRTALHLACANGhpEVVTLLVDRkcqlNVCDNENRTALMK----AVQC-----------QEEKCaTILLEHGADP 139
Cdd:PHA02736    12 EPDIEGENILHYLCRNG--GVTDLLAFK----NAISDENRYLVLEynrhGKQCvhivsnpdkadPQEKL-KLLMEWGADI 84

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217276170  140 NLAD-VHGNTALHYAVYNEDISVATKLLLY-DANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKA 203
Cdd:PHA02736    85 NGKErVFGNTPLHIAVYTQNYELATWLCNQpGVNMEILNYAFKTPYYVACERHDAKMMNILRAKGA 150
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1095-1345 1.48e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 43.47  E-value: 1.48e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1095 QESVEERLSQLQSENMLLR----QQLDDAHNKADNKEKTVINiqdqfhAIVQKLQAESEKQSLLLE----ERNKELISE- 1165
Cdd:COG3206     80 DSPLETQIEILKSRPVLERvvdkLNLDEDPLGEEASREAAIE------RLRKNLTVEPVKGSNVIEisytSPDPELAAAv 153

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1166 CNHLKE--RQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEvtsRYR-----INLEDETQDLKKKLGQIRNQLQE 1238
Cdd:COG3206    154 ANALAEayLEQNLELRREEARKALEFLEEQLPELRKELEEAEAALE---EFRqknglVDLSEEAKLLLQQLSELESQLAE 230

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1239 AQDRHTEAVRCAEKMQDHKQKLEKDNAKLK--VTVKKQMDKIEELQKNLlnANLSE---DEKEQLKKLMELKQSLECNLD 1313
Cdd:COG3206    231 ARAELAEAEARLAALRAQLGSGPDALPELLqsPVIQQLRAQLAELEAEL--AELSArytPNHPDVIALRAQIAALRAQLQ 308

                          250       260       270
                   ....*....|....*....|....*....|...
gi 2217276170 1314 QEMKKN-VELEREITGFKNLLKMTRKKLNEYEN 1345
Cdd:COG3206    309 QEAQRIlASLEAELEALQAREASLQAQLAQLEA 341
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 693-1237 1.51e-03

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 43.17  E-value: 1.51e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  693 KIQDAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEhQKVEWERElcslrfSLNQEEEKRRNAD 772
Cdd:pfam05483  223 KIQHLEEEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKANQLE-EKTKLQDE------NLKELIEKKDHLT 295

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  773 TLYEKIREQLRRKEEqyrkevevkqqlelSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNAR-MLQDGILTNHLSK 851
Cdd:pfam05483  296 KELEDIKMSLQRSMS--------------TQKALEEDLQIATKTICQLTEEKEAQMEELNKAKAAHsFVVTEFEATTCSL 361

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  852 QKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAML---RLEIDTIKNQNQEKEKKCFEdlkivKEKNEDLQKTIKQ 928
Cdd:pfam05483  362 EELLRTEQQRLEKNEDQLKIITMELQKKSSELEEMTKFKnnkEVELEELKKILAEDEKLLDE-----KKQFEKIAEELKG 436

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  929 NEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELelaFQRARDECS 1008
Cdd:pfam05483  437 KEQELIFLLQAREKEIHDLEIQLTAIKTSEEHYLKEVEDLKTELEKEKLKNIELTAHCDKLLLENKEL---TQEASDMTL 513

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1009 RLQDKMNfDVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREK----TLGLERVQKDLSQTQCQMKEMEQKYQNE 1084
Cdd:pfam05483  514 ELKKHQE-DIINCKKQEERMLKQIENLEEKEMNLRDELESVREEFIQKgdevKCKLDKSEENARSIEYEVLKKEKQMKIL 592

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1085 QVKVNKYIGKQESVEERLSQLQSENMLLR-------QQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAE------SEKQ 1151
Cdd:pfam05483  593 ENKCNNLKKQIENKNKNIEELHQENKALKkkgsaenKQLNAYEIKVNKLELELASAKQKFEEIIDNYQKEiedkkiSEEK 672

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1152 SLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASL-----EVTSRYRINLEDETQDLK 1226
Cdd:pfam05483  673 LLEEVEKAKAIADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSELGLyknkeQEQSSAKAALEIELSNIK 752

                          570
                   ....*....|.
gi 2217276170 1227 KKLGQIRNQLQ 1237
Cdd:pfam05483  753 AELLSLKKQLE 763
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1220-1492 1.61e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 42.83  E-value: 1.61e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1220 DETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLlnANLSEDEKEQLK 1299
Cdd:COG4942     20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAEL--AELEKEIAELRA 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1300 KLMELKQSLEcnldqemkknvelereitgfKNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMDIQ--INKLKHKIDDLTA 1377
Cdd:COG4942     98 ELEAQKEELA--------------------ELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKylAPARREQAEELRA 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1378 ELETagskclhLDTKNQILQEELLSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERARQEIA 1457
Cdd:COG4942    158 DLAE-------LAALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIA 230

                          250       260       270
                   ....*....|....*....|....*....|....*
gi 2217276170 1458 EklkevnlfLQAQAASQEnlEQFRENNFASMKSQM 1492
Cdd:COG4942    231 R--------LEAEAAAAA--ERTPAAGFAALKGKL 255
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
642-1246 1.78e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 42.98  E-value: 1.78e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  642 NQIQSMDDVDDLTqssetasedcELphssYKNFML-------LIEQLgmecKDSVSLLK-----IQDAALSCERLLELKK 709
Cdd:COG4913    198 HKTQSFKPIGDLD----------DF----VREYMLeepdtfeAADAL----VEHFDDLEraheaLEDAREQIELLEPIRE 259

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  710 NHcelltVKIKKMEDKVNVLQRELSETKEIKSQLEHQkvEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQY 789
Cdd:COG4913    260 LA-----ERYAAARERLAELEYLRAALRLWFAQRRLE--LLEAELEELRAELARLEAELERLEARLDALREELDELEAQI 332

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  790 RK-EVEVKQQLELSLQTLEMELRTVKSNLNQ-----------VVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEIEM 857
Cdd:COG4913    333 RGnGGDRLEQLEREIERLERELEERERRRARleallaalglpLPASAEEFAALRAEAAALLEALEEELEALEEALAEAEA 412

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  858 AQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIdtiknqnQEKEKKCFEDLKI------VKEKNEDLQKTI----- 926
Cdd:COG4913    413 ALRDLRRELRELEAEIASLERRKSNIPARLLALRDAL-------AEALGLDEAELPFvgelieVRPEEERWRGAIervlg 485

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  927 ---------KQNEETLTQTISQYNGRLSVLTaenamlnSKLENEKQSKERLEAEVESYHSRLAAAIHD-RD--QSETSKR 994
Cdd:COG4913    486 gfaltllvpPEHYAAALRWVNRLHLRGRLVY-------ERVRTGLPDPERPRLDPDSLAGKLDFKPHPfRAwlEAELGRR 558

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  995 ------ELELAFQRAR----DECsrlQDKMNFDVSNLKDNNEILSQQL--FKTESKLNSLEIEfhhtRDALREKtlgLER 1062
Cdd:COG4913    559 fdyvcvDSPEELRRHPraitRAG---QVKGNGTRHEKDDRRRIRSRYVlgFDNRAKLAALEAE----LAELEEE---LAE 628

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1063 VQKDLSQTQCQMKEMEQK---------YQNEQVKVnkyigkqESVEERLSQLQSEnmllRQQLDDAHNKadnkektVINI 1133
Cdd:COG4913    629 AEERLEALEAELDALQERrealqrlaeYSWDEIDV-------ASAEREIAELEAE----LERLDASSDD-------LAAL 690

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1134 QDQFHAIVQKLQaESEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEaslEVTSR 1213
Cdd:COG4913    691 EEQLEELEAELE-ELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLELRALLEERFAAALGD---AVERE 766

                          650       660       670
                   ....*....|....*....|....*....|...
gi 2217276170 1214 YRINLEDETQDLKKKLGQIRNQLQEAQDRHTEA 1246
Cdd:COG4913    767 LRENLEERIDALRARLNRAEEELERAMRAFNRE 799
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
966-1501 1.84e-03

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 43.11  E-value: 1.84e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  966 ERLEAEVESYHSRLAAAIHDRDQSETSKR--ELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTEsKLNSLE 1043
Cdd:PRK02224   179 ERVLSDQRGSLDQLKAQIEEKEEKDLHERlnGLESELAELDEEIERYEEQREQARETRDEADEVLEEHEERRE-ELETLE 257

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1044 IEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKA 1123
Cdd:PRK02224   258 AEIEDLRETIAETEREREELAEEVRDLRERLEELEEERDDLLAEAGLDDADAEAVEARREELEDRDEELRDRLEECRVAA 337

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1124 DNKEKtviniqdqfhaivqklQAESEKQSLL-LEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQS 1202
Cdd:PRK02224   338 QAHNE----------------EAESLREDADdLEERAEELREEAAELESELEEAREAVEDRREEIEELEEEIEELRERFG 401

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1203 MSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEA---------------------VRCAEKMQDHKQKLE 1261
Cdd:PRK02224   402 DAPVDLGNAEDFLEELREERDELREREAELEATLRTARERVEEAealleagkcpecgqpvegsphVETIEEDRERVEELE 481

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1262 KDNAKLKVTVKKQMDKIEELQKNLLNANLSEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLN 1341
Cdd:PRK02224   482 AELEDLEEEVEEVEERLERAEDLVEAEDRIERLEERREDLEELIAERRETIEEKRERAEELRERAAELEAEAEEKREAAA 561

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1342 E-YENGEFSFH--GDLKTSQFEMDIQINKLKhKIDDLTAELETAGSKCLHLDTKNQILQE-ELLSMKTVQKKCEKlqknK 1417
Cdd:PRK02224   562 EaEEEAEEAREevAELNSKLAELKERIESLE-RIRTLLAAIADAEDEIERLREKREALAElNDERRERLAEKRER----K 636

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1418 KKLEQEVINLRshIERNMVELGQVKQYKQEIEERARqEIAEKLKEVNLFLQAQAASQENLEQFRENnfasmKSQMELRIK 1497
Cdd:PRK02224   637 RELEAEFDEAR--IEEAREDKERAEEYLEQVEEKLD-ELREERDDLQAEIGAVENELEELEELRER-----REALENRVE 708


                   ....
gi 2217276170 1498 DLES 1501
Cdd:PRK02224   709 ALEA 712
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 752-1144 1.89e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 43.13  E-value: 1.89e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  752 RELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQL 831
Cdd:TIGR02169  681 ERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSEL 760

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  832 srEQNARMLQDgiltnhlsKQKEIEMAQKKMNS-ENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIknqNQEKEKKCFE 910
Cdd:TIGR02169  761 --KELEARIEE--------LEEDLHKLEEALNDlEARLSHSRIPEIQAELSKLEEEVSRIEARLREI---EQKLNRLTLE 827

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  911 dlkivKEKNEDLQKTIKQNEETLTQTISQyngrlsvLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSE 990
Cdd:TIGR02169  828 -----KEYLEKEIQELQEQRIDLKEQIKS-------IEKEIENLNGKKEELEEELEELEAALRDLESRLGDLKKERDELE 895

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  991 TSKRELelafQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEfhhtrdalREKTLGLERVQKDLSQT 1070
Cdd:TIGR02169  896 AQLREL----ERKIEELEAQIEKKRKRLSELKAKLEALEEELSEIEDPKGEDEEI--------PEEELSLEDVQAELQRV 963

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1071 QCQMKEMEQkyqneqvkVN-KYIGKQESVEERLSQLQSENMLL---RQQLDDAHNKADNKEKTV-----INIQDQFHAIV 1141
Cdd:TIGR02169  964 EEEIRALEP--------VNmLAIQEYEEVLKRLDELKEKRAKLeeeRKAILERIEEYEKKKREVfmeafEAINENFNEIF 1035


                   ...
gi 2217276170 1142 QKL 1144
Cdd:TIGR02169 1036 AEL 1038
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 178-210 1.90e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 37.27  E-value: 1.90e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 2217276170  178 DDLTPLLLAV-SGKKQQMVEFLIKKKANVNAVDK 210
Cdd:pfam00023    1 DGNTPLHLAAgRRGNLEIVKLLLSKGADVNARDK 34
ClpA COG0542
ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein ...
 1030-1172 1.93e-03

ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440308 [Multi-domain]  Cd Length: 836  Bit Score: 43.15  E-value: 1.93e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1030 QQLFKTESKLNSLEIEfhhtRDAL-REKTLG----LERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQ 1104
Cdd:COG0542    411 EELDELERRLEQLEIE----KEALkKEQDEAsferLAELRDELAELEEELEALKARWEAEKELIEEIQELKEELEQRYGK 486

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2217276170 1105 LQSenmlLRQQLDDAHNKADNKEKTVINI--QDQFHAIV--------QKLQaESEKQSLL-LEErnkelisecnHLKER 1172
Cdd:COG0542    487 IPE----LEKELAELEEELAELAPLLREEvtEEDIAEVVsrwtgipvGKLL-EGEREKLLnLEE----------ELHER 550
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 79-215 1.97e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 42.67  E-value: 1.97e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170   79 MNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPNLADVHGNTALHYAVYNED 158
Cdd:PHA02875     1 MDQVALCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGD 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  159 ISVATKLLLYDANI-EAKNKDDLTPLLLAVSGKKQQMVEFLIKKKA--NVNAVDKLESSH 215
Cdd:PHA02875    81 VKAVEELLDLGKFAdDVFYKDGMTPLHLATILKKLDIMKLLIARGAdpDIPNTDKFSPLH 140
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1133-1553 2.09e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 42.83  E-value: 2.09e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1133 IQDQFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYenekaerevvvRQLQQELADTLKKQSMSEASLEVTS 1212
Cdd:COG4717     47 LLERLEKEADELFKPQGRKPELNLKELKELEEELKEAEEKEEEY-----------AELQEELEELEEELEELEAELEELR 115

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1213 RYRINLEDETQ--DLKKKLGQIRNQLQEAQDRHTEAVrcaEKMQDHKQkLEKDNAKLKVTVKKQMDKIEELQKNLLNANL 1290
Cdd:COG4717    116 EELEKLEKLLQllPLYQELEALEAELAELPERLEELE---ERLEELRE-LEEELEELEAELAELQEELEELLEQLSLATE 191

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1291 SEDE--KEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMDIQINKL 1368
Cdd:COG4717    192 EELQdlAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERLKEARLLLLIAAALLALLGLGGSLLSL 271

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1369 KHKIDDLTAELETAGSKCLHLDTKNQILQEELLSMKTVQKKCEKLQKNKKK--LEQEVINLRSHIERNMVELGQVKQYKQ 1446
Cdd:COG4717    272 ILTIAGVLFLVLGLLALLFLLLAREKASLGKEAEELQALPALEELEEEELEelLAALGLPPDLSPEELLELLDRIEELQE 351

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1447 EIEERARQEIAEKLKEVNLFLQA--QAASQENLEQFRE-----NNFASMKSQMELRIKDLESELSKIKTSQEDFNKTELE 1519
Cdd:COG4717    352 LLREAEELEEELQLEELEQEIAAllAEAGVEDEEELRAaleqaEEYQELKEELEELEEQLEELLGELEELLEALDEEELE 431

                          410       420       430
                   ....*....|....*....|....*....|....
gi 2217276170 1520 KYKQLYLEELkvrKSLSSKLTKTNERLAEVNTKL 1553
Cdd:COG4717    432 EELEELEEEL---EELEEELEELREELAELEAEL 462
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
718-1077 2.56e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 42.59  E-value: 2.56e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  718 KIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTlyekiREQLRRKEEQYRkevevkq 797
Cdd:COG4913    611 KLAALEAELAELEEELAEAEERLEALEAELDALQERREALQRLAEYSWDEIDVASA-----EREIAELEAELE------- 678

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  798 QLELS---LQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNARmlqdgiltnhlsKQKEIEMAQKKMNSENSHSHEEEK 874
Cdd:COG4913    679 RLDASsddLAALEEQLEELEAELEELEEELDELKGEIGRLEKEL------------EQAEEELDELQDRLEAAEDLARLE 746

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  875 DLSHKNSMLQEEIAmlrleidtiknqnQEKEKKCFEDLkivKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAE---- 950
Cdd:COG4913    747 LRALLEERFAAALG-------------DAVERELRENL---EERIDALRARLNRAEEELERAMRAFNREWPAETADldad 810

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  951 -------NAMLNsKLENekqskERLEAevesYHSRLAAAIHdrDQSETSKRELELAFQRARDECSRlqdkmnfdvsNLKD 1023
Cdd:COG4913    811 leslpeyLALLD-RLEE-----DGLPE----YEERFKELLN--ENSIEFVADLLSKLRRAIREIKE----------RIDP 868

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217276170 1024 NNEILSQQLFKTESKLnSLEI------EFHHTRDALREKTLGLERVQKDLSQTQC-QMKEM 1077
Cdd:COG4913    869 LNDSLKRIPFGPGRYL-RLEArprpdpEVREFRQELRAVTSGASLFDEELSEARFaALKRL 928
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1066-1246 2.72e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 42.12  E-value: 2.72e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1066 DLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQ 1145
Cdd:COG3883     17 QIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGERARALY 96

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1146 AESEKQSLL---------------------LEERNKELISEcnhLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMS 1204
Cdd:COG3883     97 RSGGSVSYLdvllgsesfsdfldrlsalskIADADADLLEE---LKADKAELEAKKAELEAKLAELEALKAELEAAKAEL 173

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 2217276170 1205 EASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEA 1246
Cdd:COG3883    174 EAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAA 215
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 884-1108 2.86e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 42.06  E-value: 2.86e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  884 QEEIAMLRLEIDTIKNQNQEKEKKcfedlkivKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQ 963
Cdd:COG4942     19 ADAAAEAEAELEQLQQEIAELEKE--------LAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEK 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  964 SKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLE 1043
Cdd:COG4942     91 EIAELRAELEAQKEELAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELE 170

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2217276170 1044 IEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSE 1108
Cdd:COG4942    171 AERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAE 235
PHA02946 PHA02946
ankyin-like protein; Provisional
 80-215 3.20e-03

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 41.96  E-value: 3.20e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170   80 NRTALHLACA-NGHPE-VVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPNLADVHGNTALHYAVYNE 157
Cdd:PHA02946    37 NYHILHAYCGiKGLDErFVEELLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLYYLSGTD 116

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  158 D--ISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKANVNAVDKLESSH 215
Cdd:PHA02946   117 DevIERINLLVQYGAKINNSVDEEGCGPLLACTDPSERVFKKIMSIGFEARIVDKFGKNH 176
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 50-224 4.14e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 41.79  E-value: 4.14e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170   50 IHKAASAGNVAKVQQiLLLRKNGLNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNEnrTALMKAVQCQEEKCA 129
Cdd:PHA02878    41 LHQAVEARNLDVVKS-LLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMIRSINKCSVFYTL--VAIKDAFNNRNVEIF 117

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  130 TILLEHGADPN--LADVHGNTALHYAVYNEDIsvaTKLLL-YDANIEAKNKDDL-TPLLLAVSGKKQQMVEFLIKKKANV 205
Cdd:PHA02878   118 KIILTNRYKNIqtIDLVYIDKKSKDDIIEAEI---TKLLLsYGADINMKDRHKGnTALHYATENKDQRLTELLLSYGANV 194

                          170       180
                   ....*....|....*....|.
gi 2217276170  206 NAVDKLESS--HQLISEYKEE 224
Cdd:PHA02878   195 NIPDKTNNSplHHAVKHYNKP 215
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 145-174 4.20e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.41  E-value: 4.20e-03
                            10        20        30
                    ....*....|....*....|....*....|
gi 2217276170   145 HGNTALHYAVYNEDISVATKLLLYDANIEA 174
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
703-1157 4.21e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 41.68  E-value: 4.21e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  703 RLLELKKNHCELLTVKIKKMEDKvnvlQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTL--YEKIRE 780
Cdd:COG4717     64 RKPELNLKELKELEEELKEAEEK----EEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQLLPLYqeLEALEA 139

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  781 QLRRKEEQYRkevEVKQQLElSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQK 860
Cdd:COG4717    140 ELAELPERLE---ELEERLE-ELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQRLAELEEEL 215

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  861 KMNSENSHSHEEEKDLSHKNSMLQEE------------IAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQ 928
Cdd:COG4717    216 EEAQEELEELEEELEQLENELEAAALeerlkearllllIAAALLALLGLGGSLLSLILTIAGVLFLVLGLLALLFLLLAR 295

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  929 NEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELafQRARDECS 1008
Cdd:COG4717    296 EKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEELQL--EELEQEIA 373

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1009 RLQDKmnFDVSNLKDNNEILSQQlfkteSKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQC--QMKEMEQKYQNEQV 1086
Cdd:COG4717    374 ALLAE--AGVEDEEELRAALEQA-----EEYQELKEELEELEEQLEELLGELEELLEALDEEELeeELEELEEELEELEE 446

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217276170 1087 KVNKYIGKQESVEERLSQLQSENML--LRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQ-AESEKQSLLLEE 1157
Cdd:COG4717    447 ELEELREELAELEAELEQLEEDGELaeLLQELEELKAELRELAEEWAALKLALELLEEAREeYREERLPPVLER 520
COG5022 COG5022
Myosin heavy chain [General function prediction only];
720-1346 4.36e-03

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 41.99  E-value: 4.36e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  720 KKMEDKVNVLQRELsETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNA---DTLYEKI---REQLRRKEEQYRKEV 793
Cdd:COG5022    813 RSYLACIIKLQKTI-KREKKLRETEEVEFSLKAEVLIQKFGRSLKAKKRFSLlkkETIYLQSaqrVELAERQLQELKIDV 891

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  794 EVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQnARMLQDGILTNHLSKQKEIEMAQKKMNSENSHSHEEE 873
Cdd:COG5022    892 KSISSLKLVNLELESEIIELKKSLSSDLIENLEFKTELIARL-KKLLNNIDLEEGPSIEYVKLPELNKLHEVESKLKETS 970

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  874 KDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKcfedlkivKEKNEDLQKTIKQNEETltqtisqyNGRLSVLTAENAM 953
Cdd:COG5022    971 EEYEDLLKKSTILVREGNKANSELKNFKKELAEL--------SKQYGALQESTKQLKEL--------PVEVAELQSASKI 1034

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  954 LNSKLENEKQSKErlEAEVESyhsrlaaaIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLF 1033
Cdd:COG5022   1035 ISSESTELSILKP--LQKLKG--------LLLLENNQLQARYKALKLRRENSLLDDKQLYQLESTENLLKTINVKDLEVT 1104

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1034 KTESKLNSLEIEF-----------HHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQV---KVNKYIGKQESV- 1098
Cdd:COG5022   1105 NRNLVKPANVLQFivaqmiklnllQEISKFLSQLVNTLEPVFQKLSVLQLELDGLFWEANLEALpspPPFAALSEKRLYq 1184

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1099 ----EERLSQLQSENMLLRQQLD---DAHNKADNKEKTVINIQDQ---FHAIVQKLQAESEKQSLLLEER---NKELISE 1165
Cdd:COG5022   1185 salyDEKSKLSSSEVNDLKNELIalfSKIFSGWPRGDKLKKLISEgwvPTEYSTSLKGFNNLNKKFDTPAsmsNEKLLSL 1264

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1166 CNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQ-SMSEASLEVTSRYRINlEDETQDLKKKLGQIRNQLQEAQDRHT 1244
Cdd:COG5022   1265 LNSIDNLLSSYKLEEEVLPATINSLLQYINVGLFNAlRTKASSLRWKSATEVN-YNSEELDDWCREFEISDVDEELEELI 1343

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1245 EAVRCaekmqdhKQKLEKDNAKLKVTVkkqmdKIEELQKNLLNANLSEDEKEQLKklmelkqslECNLDQEMKKNV---- 1320
Cdd:COG5022   1344 QAVKV-------LQLLKDDLNKLDELL-----DACYSLNPAEIQNLKSRYDPADK---------ENNLPKEILKKIeall 1402

                          650       660
                   ....*....|....*....|....*....
gi 2217276170 1321 ---ELEREITGFKNLLKMTRKKLNEYENG 1346
Cdd:COG5022   1403 ikqELQLSLEGKDETEVHLSEIFSEEKSL 1431
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1078-1297 4.57e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 41.35  E-value: 4.57e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1078 EQKYQNEQVKVNKYIGKQESVEERLSQLQsenmllrQQLDDAHNKADNKEKTVINIQDQfhaiVQKLQAESEKQSLLLEE 1157
Cdd:COG3883     15 DPQIQAKQKELSELQAELEAAQAELDALQ-------AELEELNEEYNELQAELEALQAE----IDKLQAEIAEAEAEIEE 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1158 RNKELisecnhlKER-QYQYENEKA-----------------EREVVVRQLQQELADTLKKQSMSEASLEvtsRYRINLE 1219
Cdd:COG3883     84 RREEL-------GERaRALYRSGGSvsyldvllgsesfsdflDRLSALSKIADADADLLEELKADKAELE---AKKAELE 153

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2217276170 1220 DETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDEKEQ 1297
Cdd:COG3883    154 AKLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAA 231
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
702-1140 4.83e-03

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 41.59  E-value: 4.83e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  702 ERLLELKKNHCELltVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQ 781
Cdd:PRK03918   273 KEIEELEEKVKEL--KELKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKELEEKEERLEELKKKLKEL 350

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  782 LRRKEEqyrkevevkqqLELSLQTLEmELRTVKSNLNQVVQERNDaqrqLSREQNARMLQDgiltnhLSKQK-EIEMAQK 860
Cdd:PRK03918   351 EKRLEE-----------LEERHELYE-EAKAKKEELERLKKRLTG----LTPEKLEKELEE------LEKAKeEIEEEIS 408

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  861 KMNSENSHSHEEEKDLSHKNSMLQ-------------------EEIAMLRLEIDTIKNQNQEKEKKcFEDLKIVKEKNED 921
Cdd:PRK03918   409 KITARIGELKKEIKELKKAIEELKkakgkcpvcgrelteehrkELLEEYTAELKRIEKELKEIEEK-ERKLRKELRELEK 487

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  922 L---QKTIKQNEETLTQtISQYNGRLSVLTAENamLNSKLENEKQSKERLeAEVESYHSRLAAAIHDRDQSETSKRELEL 998
Cdd:PRK03918   488 VlkkESELIKLKELAEQ-LKELEEKLKKYNLEE--LEKKAEEYEKLKEKL-IKLKGEIKSLKKELEKLEELKKKLAELEK 563

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  999 AFQRARDECSRLQDKM-NFDVSNLKDNNEILSQ---------QLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLS 1068
Cdd:PRK03918   564 KLDELEEELAELLKELeELGFESVEELEERLKElepfyneylELKDAEKELEREEKELKKLEEELDKAFEELAETEKRLE 643

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2217276170 1069 QTQCQMKEMEQKYQNEqvkvnkyigKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAI 1140
Cdd:PRK03918   644 ELRKELEELEKKYSEE---------EYEELREEYLELSRELAGLRAELEELEKRREEIKKTLEKLKEELEER 706
PRK11281 PRK11281
mechanosensitive channel MscK;
718-1076 5.03e-03

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 41.82  E-value: 5.03e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  718 KIKKMEDKVNVLQRELSETKEIKSQLEHQKveweRELCSLRFSLNQEEEKRRNADTLYEKIREQLrrkeeqyrkEVEVKQ 797
Cdd:PRK11281    50 KQKLLEAEDKLVQQDLEQTLALLDKIDRQK----EETEQLKQQLAQAPAKLRQAQAELEALKDDN---------DEETRE 116

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  798 QLE-LSLQTLEmelrtvkSNLNQVVQERNDAQRQLSrEQNARMlqdgiltnhLSKQKEIEMAQKKMNSENSHSHEEEKDL 876
Cdd:PRK11281   117 TLStLSLRQLE-------SRLAQTLDQLQNAQNDLA-EYNSQL---------VSLQTQPERAQAALYANSQRLQQIRNLL 179

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  877 SH----KNSMLQEEIAMLRLEIDTIKNQNqekekkcfedlkivkekneDLQKTIKQNEETLTQTisqYNGRLSVLTAENA 952
Cdd:PRK11281   180 KGgkvgGKALRPSQRVLLQAEQALLNAQN-------------------DLQRKSLEGNTQLQDL---LQKQRDYLTARIQ 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  953 mlnsklenekqskeRLEAEVESyhsrLAAAIHDR--DQSETSKRELElafqrARDECSRLQDkmNFDVSNLKDNNEILSQ 1030
Cdd:PRK11281   238 --------------RLEHQLQL----LQEAINSKrlTLSEKTVQEAQ-----SQDEAARIQA--NPLVAQELEINLQLSQ 292

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*.
gi 2217276170 1031 QLFKTESKLNSLeiefhhTRDALREKTLgLERvqkdLSQTQCQMKE 1076
Cdd:PRK11281   293 RLLKATEKLNTL------TQQNLRVKNW-LDR----LTQSERNIKE 327
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1008-1482 5.67e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 41.29  E-value: 5.67e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1008 SRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEI---EFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNE 1084
Cdd:COG4717     49 ERLEKEADELFKPQGRKPELNLKELKELEEELKEAEEkeeEYAELQEELEELEEELEELEAELEELREELEKLEKLLQLL 128

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1085 QvkvnkYIGKQESVEERLSQLQSENMLLRQQLD---DAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKE 1161
Cdd:COG4717    129 P-----LYQELEALEAELAELPERLEELEERLEelrELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEE 203

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1162 LISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEA-----------SLEVTSRYRINLEDE--------- 1221
Cdd:COG4717    204 LQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERLKEArlllliaaallALLGLGGSLLSLILTiagvlflvl 283

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1222 ------TQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNAnlsEDEK 1295
Cdd:COG4717    284 gllallFLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLREA---EELE 360

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1296 EQLKkLMELKQSLECNLDQemkKNVELEREItgfknllkmtRKKLNEYEngefsfhgdlktsqfemdiQINKLKHKIDDL 1375
Cdd:COG4717    361 EELQ-LEELEQEIAALLAE---AGVEDEEEL----------RAALEQAE-------------------EYQELKEELEEL 407

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1376 TAELEtagskclhldtknQILQEELLSMKTVQKkcEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEE----- 1450
Cdd:COG4717    408 EEQLE-------------ELLGELEELLEALDE--EELEEELEELEEELEELEEELEELREELAELEAELEQLEEdgela 472

                          490       500       510
                   ....*....|....*....|....*....|....*
gi 2217276170 1451 RARQEIAEKLKEVNLFLQ---AQAASQENLEQFRE 1482
Cdd:COG4717    473 ELLQELEELKAELRELAEewaALKLALELLEEARE 507
EzrA pfam06160
Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like ...
 1226-1558 6.13e-03

Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like cell-division protein FtsZ polymerizes into a ring structure that establishes the location of the nascent division site. EzrA modulates the frequency and position of FtsZ ring formation. The structure contains 5 spectrin like alpha helical repeats.


Pssm-ID: 428797 [Multi-domain]  Cd Length: 542  Bit Score: 40.99  E-value: 6.13e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1226 KKKLGQIRNQLQEAQDRhteavrcAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLS-------------- 1291
Cdd:pfam06160   85 KKALDEIEELLDDIEED-------IKQILEELDELLESEEKNREEVEELKDKYRELRKTLLANRFSygpaidelekqlae 157

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1292 -EDEKEQLKKLMELKQSLECN--LDQEMKKNVELEREITGFKNLLKMTRK----KLNEYENGefsfHGDLKTSQF----- 1359
Cdd:pfam06160  158 iEEEFSQFEELTESGDYLEARevLEKLEEETDALEELMEDIPPLYEELKTelpdQLEELKEG----YREMEEEGYalehl 233

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1360 EMDIQINKLKHKIDDLTAELETagskcLHLDT---KNQILQEELLSM-----------KTVQKKCEKLQKNKKKLEQEVI 1425
Cdd:pfam06160  234 NVDKEIQQLEEQLEENLALLEN-----LELDEaeeALEEIEERIDQLydllekevdakKYVEKNLPEIEDYLEHAEEQNK 308

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1426 NLRSHIER-------NMVELGQVKQYKQEIEerarqEIAEKLKEVNLFLQAQAASQenleqfrennfasmkSQMELRIKD 1498
Cdd:pfam06160  309 ELKEELERvqqsytlNENELERVRGLEKQLE-----ELEKRYDEIVERLEEKEVAY---------------SELQEELEE 368

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170 1499 LESELSKIKTSQEDFNktelEKYKQLYLEELKVRKslssKLTKTNERLAEVntKLLVEKQ 1558
Cdd:pfam06160  369 ILEQLEEIEEEQEEFK----ESLQSLRKDELEARE----KLDEFKLELREI--KRLVEKS 418
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 95-209 6.61e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 41.20  E-value: 6.61e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170   95 VVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIea 174
Cdd:PHA02876   160 IAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSNI-- 237

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 2217276170  175 kNKDDLTpLLLAVSGKKQQMVEFLIKKKANVNAVD 209
Cdd:PHA02876   238 -NKNDLS-LLKAIRNEDLETSLLLYDAGFSVNSID 270
PRK09039 PRK09039
peptidoglycan -binding protein;
933-1043 9.91e-03

peptidoglycan -binding protein;


Pssm-ID: 181619 [Multi-domain]  Cd Length: 343  Bit Score: 39.95  E-value: 9.91e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276170  933 LTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELElafqRARDECSRLQD 1012
Cdd:PRK09039    44 LSREISGKDSALDRLNSQIAELADLLSLERQGNQDLQDSVANLRASLSAAEAERSRLQALLAELA----GAGAAAEGRAG 119

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 2217276170 1013 KMNFDVSNLKDNN-------EILSQQLFKTESKLNSLE 1043
Cdd:PRK09039   120 ELAQELDSEKQVSaralaqvELLNQQIAALRRQLAALE 157
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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