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Conserved domains on  [gi|2217277465|ref|XP_047281270|]
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WW domain-containing adapter protein with coiled-coil isoform X10 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
WW pfam00397
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ...
215-242 6.42e-09

WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.


:

Pssm-ID: 459800 [Multi-domain]  Cd Length: 30  Bit Score: 51.35  E-value: 6.42e-09
                          10        20
                  ....*....|....*....|....*...
gi 2217277465 215 DDWSEHISSSGKKYYYNCRTEVSQWEKP 242
Cdd:pfam00397   3 PGWEERWDPDGRVYYYNHETGETQWEKP 30
Herpes_BLLF1 super family cl37540
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
279-537 1.05e-04

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


The actual alignment was detected with superfamily member pfam05109:

Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 45.29  E-value: 1.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217277465 279 TSGFASGKSTSGDKPVSH--------SCTTPSTSSASGLNPTSAPPTSASavpvSPVPQSPIPpllQDPNLLRQLLPALQ 350
Cdd:pfam05109 436 TTGFAAPNTTTGLPSSTHvptnltapASTGPTVSTADVTSPTPAGTTSGA----SPVTPSPSP---RDNGTESKAPDMTS 508
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217277465 351 ATLQLNNSNVDISKINEVLTAAVTQASLQSI-----IHKFLTAGPSAFNITSLISQAAQLSTQAQPSNQSPMSLTSDASS 425
Cdd:pfam05109 509 PTSAVTTPTPNATSPTPAVTTPTPNATSPTLgktspTSAVTTPTPNATSPTPAVTTPTPNATIPTLGKTSPTSAVTTPTP 588
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217277465 426 PRSYVSPRISTPQTNTV--PIKPLISTPPVSSQPKVSTPVVKQG---------------PVSQSATQQPVTADKQQGHEP 488
Cdd:pfam05109 589 NATSPTVGETSPQANTTnhTLGGTSSTPVVTSPPKNATSAVTTGqhnitssstssmslrPSSISETLSPSTSDNSTSHMP 668
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2217277465 489 V----SPRSLQRSSSQRSPSPGPNHTSNSSNASNATVVPQNSS-ARSTCSLTPA 537
Cdd:pfam05109 669 LltsaHPTGGENITQVTPASTSTHHVSTSSPAPRPGTTSQASGpGNSSTSTKPG 722
PRP40 super family cl34905
Splicing factor [RNA processing and modification];
213-280 1.79e-03

Splicing factor [RNA processing and modification];


The actual alignment was detected with superfamily member COG5104:

Pssm-ID: 227435 [Multi-domain]  Cd Length: 590  Bit Score: 41.22  E-value: 1.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217277465 213 SADDWSEHISSSGKKYYYNCRTEVSQWEKPKEW--LEREQRQKEA---------NKMAVNSFPKD---RDYRREVMQATA 278
Cdd:COG5104    54 DVDPWKECRTADGKVYYYNSITRESRWKIPPERkkVEPIAEQKHDersmiggngNDMAITDHETSepkYLLGRLMSQYGI 133

                  ..
gi 2217277465 279 TS 280
Cdd:COG5104   134 TS 135
 
Name Accession Description Interval E-value
WW pfam00397
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ...
215-242 6.42e-09

WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.


Pssm-ID: 459800 [Multi-domain]  Cd Length: 30  Bit Score: 51.35  E-value: 6.42e-09
                          10        20
                  ....*....|....*....|....*...
gi 2217277465 215 DDWSEHISSSGKKYYYNCRTEVSQWEKP 242
Cdd:pfam00397   3 PGWEERWDPDGRVYYYNHETGETQWEKP 30
WW cd00201
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; ...
215-244 2.43e-08

Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.


Pssm-ID: 238122 [Multi-domain]  Cd Length: 31  Bit Score: 49.83  E-value: 2.43e-08
                          10        20        30
                  ....*....|....*....|....*....|
gi 2217277465 215 DDWSEHISSSGKKYYYNCRTEVSQWEKPKE 244
Cdd:cd00201     2 PGWEERWDPDGRVYYYNHNTKETQWEDPRE 31
WW smart00456
Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds ...
217-244 1.94e-06

Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds proline-rich polypeptides.


Pssm-ID: 197736 [Multi-domain]  Cd Length: 33  Bit Score: 44.51  E-value: 1.94e-06
                           10        20
                   ....*....|....*....|....*...
gi 2217277465  217 WSEHISSSGKKYYYNCRTEVSQWEKPKE 244
Cdd:smart00456   6 WEERKDPDGRPYYYNHETKETQWEKPRE 33
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
279-537 1.05e-04

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 45.29  E-value: 1.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217277465 279 TSGFASGKSTSGDKPVSH--------SCTTPSTSSASGLNPTSAPPTSASavpvSPVPQSPIPpllQDPNLLRQLLPALQ 350
Cdd:pfam05109 436 TTGFAAPNTTTGLPSSTHvptnltapASTGPTVSTADVTSPTPAGTTSGA----SPVTPSPSP---RDNGTESKAPDMTS 508
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217277465 351 ATLQLNNSNVDISKINEVLTAAVTQASLQSI-----IHKFLTAGPSAFNITSLISQAAQLSTQAQPSNQSPMSLTSDASS 425
Cdd:pfam05109 509 PTSAVTTPTPNATSPTPAVTTPTPNATSPTLgktspTSAVTTPTPNATSPTPAVTTPTPNATIPTLGKTSPTSAVTTPTP 588
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217277465 426 PRSYVSPRISTPQTNTV--PIKPLISTPPVSSQPKVSTPVVKQG---------------PVSQSATQQPVTADKQQGHEP 488
Cdd:pfam05109 589 NATSPTVGETSPQANTTnhTLGGTSSTPVVTSPPKNATSAVTTGqhnitssstssmslrPSSISETLSPSTSDNSTSHMP 668
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2217277465 489 V----SPRSLQRSSSQRSPSPGPNHTSNSSNASNATVVPQNSS-ARSTCSLTPA 537
Cdd:pfam05109 669 LltsaHPTGGENITQVTPASTSTHHVSTSSPAPRPGTTSQASGpGNSSTSTKPG 722
PRP40 COG5104
Splicing factor [RNA processing and modification];
214-250 5.06e-04

Splicing factor [RNA processing and modification];


Pssm-ID: 227435 [Multi-domain]  Cd Length: 590  Bit Score: 43.15  E-value: 5.06e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2217277465 214 ADDWSEHISSSGKKYYYNCRTEVSQWEKPKEWLEREQ 250
Cdd:COG5104    14 RSEWEELKAPDGRIYYYNKRTGKSSWEKPKELLKGSE 50
PRP40 COG5104
Splicing factor [RNA processing and modification];
213-280 1.79e-03

Splicing factor [RNA processing and modification];


Pssm-ID: 227435 [Multi-domain]  Cd Length: 590  Bit Score: 41.22  E-value: 1.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217277465 213 SADDWSEHISSSGKKYYYNCRTEVSQWEKPKEW--LEREQRQKEA---------NKMAVNSFPKD---RDYRREVMQATA 278
Cdd:COG5104    54 DVDPWKECRTADGKVYYYNSITRESRWKIPPERkkVEPIAEQKHDersmiggngNDMAITDHETSepkYLLGRLMSQYGI 133

                  ..
gi 2217277465 279 TS 280
Cdd:COG5104   134 TS 135
 
Name Accession Description Interval E-value
WW pfam00397
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ...
215-242 6.42e-09

WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.


Pssm-ID: 459800 [Multi-domain]  Cd Length: 30  Bit Score: 51.35  E-value: 6.42e-09
                          10        20
                  ....*....|....*....|....*...
gi 2217277465 215 DDWSEHISSSGKKYYYNCRTEVSQWEKP 242
Cdd:pfam00397   3 PGWEERWDPDGRVYYYNHETGETQWEKP 30
WW cd00201
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; ...
215-244 2.43e-08

Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.


Pssm-ID: 238122 [Multi-domain]  Cd Length: 31  Bit Score: 49.83  E-value: 2.43e-08
                          10        20        30
                  ....*....|....*....|....*....|
gi 2217277465 215 DDWSEHISSSGKKYYYNCRTEVSQWEKPKE 244
Cdd:cd00201     2 PGWEERWDPDGRVYYYNHNTKETQWEDPRE 31
WW smart00456
Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds ...
217-244 1.94e-06

Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds proline-rich polypeptides.


Pssm-ID: 197736 [Multi-domain]  Cd Length: 33  Bit Score: 44.51  E-value: 1.94e-06
                           10        20
                   ....*....|....*....|....*...
gi 2217277465  217 WSEHISSSGKKYYYNCRTEVSQWEKPKE 244
Cdd:smart00456   6 WEERKDPDGRPYYYNHETKETQWEKPRE 33
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
279-537 1.05e-04

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 45.29  E-value: 1.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217277465 279 TSGFASGKSTSGDKPVSH--------SCTTPSTSSASGLNPTSAPPTSASavpvSPVPQSPIPpllQDPNLLRQLLPALQ 350
Cdd:pfam05109 436 TTGFAAPNTTTGLPSSTHvptnltapASTGPTVSTADVTSPTPAGTTSGA----SPVTPSPSP---RDNGTESKAPDMTS 508
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217277465 351 ATLQLNNSNVDISKINEVLTAAVTQASLQSI-----IHKFLTAGPSAFNITSLISQAAQLSTQAQPSNQSPMSLTSDASS 425
Cdd:pfam05109 509 PTSAVTTPTPNATSPTPAVTTPTPNATSPTLgktspTSAVTTPTPNATSPTPAVTTPTPNATIPTLGKTSPTSAVTTPTP 588
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217277465 426 PRSYVSPRISTPQTNTV--PIKPLISTPPVSSQPKVSTPVVKQG---------------PVSQSATQQPVTADKQQGHEP 488
Cdd:pfam05109 589 NATSPTVGETSPQANTTnhTLGGTSSTPVVTSPPKNATSAVTTGqhnitssstssmslrPSSISETLSPSTSDNSTSHMP 668
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2217277465 489 V----SPRSLQRSSSQRSPSPGPNHTSNSSNASNATVVPQNSS-ARSTCSLTPA 537
Cdd:pfam05109 669 LltsaHPTGGENITQVTPASTSTHHVSTSSPAPRPGTTSQASGpGNSSTSTKPG 722
PRP40 COG5104
Splicing factor [RNA processing and modification];
214-250 5.06e-04

Splicing factor [RNA processing and modification];


Pssm-ID: 227435 [Multi-domain]  Cd Length: 590  Bit Score: 43.15  E-value: 5.06e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2217277465 214 ADDWSEHISSSGKKYYYNCRTEVSQWEKPKEWLEREQ 250
Cdd:COG5104    14 RSEWEELKAPDGRIYYYNKRTGKSSWEKPKELLKGSE 50
PRP40 COG5104
Splicing factor [RNA processing and modification];
213-280 1.79e-03

Splicing factor [RNA processing and modification];


Pssm-ID: 227435 [Multi-domain]  Cd Length: 590  Bit Score: 41.22  E-value: 1.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217277465 213 SADDWSEHISSSGKKYYYNCRTEVSQWEKPKEW--LEREQRQKEA---------NKMAVNSFPKD---RDYRREVMQATA 278
Cdd:COG5104    54 DVDPWKECRTADGKVYYYNSITRESRWKIPPERkkVEPIAEQKHDersmiggngNDMAITDHETSepkYLLGRLMSQYGI 133

                  ..
gi 2217277465 279 TS 280
Cdd:COG5104   134 TS 135
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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