ribosome biogenesis protein BMS1 homolog isoform X4 [Homo sapiens]
Protein Classification
BMS1 and AARP2CN domain-containing protein( domain architecture ID 10111837)
BMS1 and AARP2CN domain-containing protein
List of domain hits
| Name | Accession | Description | Interval | E-value | ||||
| BMS1 | cd01882 | Bms1, an essential GTPase, promotes assembly of preribosomal RNA processing complexes; Bms1 is ... |
44-273 | 2.25e-169 | ||||
Bms1, an essential GTPase, promotes assembly of preribosomal RNA processing complexes; Bms1 is an essential, evolutionarily conserved, nucleolar protein. Its depletion interferes with processing of the 35S pre-rRNA at sites A0, A1, and A2, and the formation of 40S subunits. Bms1, the putative endonuclease Rc11, and the essential U3 small nucleolar RNA form a stable subcomplex that is believed to control an early step in the formation of the 40S subumit. The C-terminal domain of Bms1 contains a GTPase-activating protein (GAP) that functions intramolecularly. It is believed that Rc11 activates Bms1 by acting as a guanine-nucleotide exchange factor (GEF) to promote GDP/GTP exchange, and that activated (GTP-bound) Bms1 delivers Rc11 to the preribosomes. : Pssm-ID: 206669 [Multi-domain] Cd Length: 231 Bit Score: 490.31 E-value: 2.25e-169
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| AARP2CN | smart00785 | AARP2CN (NUC121) domain; This domain is the central domain of AARP2. It is weakly similar to ... |
231-317 | 1.25e-37 | ||||
AARP2CN (NUC121) domain; This domain is the central domain of AARP2. It is weakly similar to the GTP-binding domain of elongation factor TU. : Pssm-ID: 129021 [Multi-domain] Cd Length: 83 Bit Score: 135.38 E-value: 1.25e-37
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| Name | Accession | Description | Interval | E-value | ||||||
| BMS1 | cd01882 | Bms1, an essential GTPase, promotes assembly of preribosomal RNA processing complexes; Bms1 is ... |
44-273 | 2.25e-169 | ||||||
Bms1, an essential GTPase, promotes assembly of preribosomal RNA processing complexes; Bms1 is an essential, evolutionarily conserved, nucleolar protein. Its depletion interferes with processing of the 35S pre-rRNA at sites A0, A1, and A2, and the formation of 40S subunits. Bms1, the putative endonuclease Rc11, and the essential U3 small nucleolar RNA form a stable subcomplex that is believed to control an early step in the formation of the 40S subumit. The C-terminal domain of Bms1 contains a GTPase-activating protein (GAP) that functions intramolecularly. It is believed that Rc11 activates Bms1 by acting as a guanine-nucleotide exchange factor (GEF) to promote GDP/GTP exchange, and that activated (GTP-bound) Bms1 delivers Rc11 to the preribosomes. Pssm-ID: 206669 [Multi-domain] Cd Length: 231 Bit Score: 490.31 E-value: 2.25e-169
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| BMS1 | COG5192 | GTP-binding protein required for 40S ribosome biogenesis [Translation, ribosomal structure and ... |
41-410 | 4.28e-137 | ||||||
GTP-binding protein required for 40S ribosome biogenesis [Translation, ribosomal structure and biogenesis]; Pssm-ID: 227519 [Multi-domain] Cd Length: 1077 Bit Score: 435.71 E-value: 4.28e-137
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| AARP2CN | pfam08142 | AARP2CN (NUC121) domain; This domain is the central domain of AARP2. It is weakly similar to ... |
231-316 | 3.16e-43 | ||||||
AARP2CN (NUC121) domain; This domain is the central domain of AARP2. It is weakly similar to the GTP-binding domain of elongation factor TU. Pssm-ID: 462369 Cd Length: 86 Bit Score: 151.12 E-value: 3.16e-43
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| AARP2CN | smart00785 | AARP2CN (NUC121) domain; This domain is the central domain of AARP2. It is weakly similar to ... |
231-317 | 1.25e-37 | ||||||
AARP2CN (NUC121) domain; This domain is the central domain of AARP2. It is weakly similar to the GTP-binding domain of elongation factor TU. Pssm-ID: 129021 [Multi-domain] Cd Length: 83 Bit Score: 135.38 E-value: 1.25e-37
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| Name | Accession | Description | Interval | E-value | ||||||
| BMS1 | cd01882 | Bms1, an essential GTPase, promotes assembly of preribosomal RNA processing complexes; Bms1 is ... |
44-273 | 2.25e-169 | ||||||
Bms1, an essential GTPase, promotes assembly of preribosomal RNA processing complexes; Bms1 is an essential, evolutionarily conserved, nucleolar protein. Its depletion interferes with processing of the 35S pre-rRNA at sites A0, A1, and A2, and the formation of 40S subunits. Bms1, the putative endonuclease Rc11, and the essential U3 small nucleolar RNA form a stable subcomplex that is believed to control an early step in the formation of the 40S subumit. The C-terminal domain of Bms1 contains a GTPase-activating protein (GAP) that functions intramolecularly. It is believed that Rc11 activates Bms1 by acting as a guanine-nucleotide exchange factor (GEF) to promote GDP/GTP exchange, and that activated (GTP-bound) Bms1 delivers Rc11 to the preribosomes. Pssm-ID: 206669 [Multi-domain] Cd Length: 231 Bit Score: 490.31 E-value: 2.25e-169
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| BMS1 | COG5192 | GTP-binding protein required for 40S ribosome biogenesis [Translation, ribosomal structure and ... |
41-410 | 4.28e-137 | ||||||
GTP-binding protein required for 40S ribosome biogenesis [Translation, ribosomal structure and biogenesis]; Pssm-ID: 227519 [Multi-domain] Cd Length: 1077 Bit Score: 435.71 E-value: 4.28e-137
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| AARP2CN | pfam08142 | AARP2CN (NUC121) domain; This domain is the central domain of AARP2. It is weakly similar to ... |
231-316 | 3.16e-43 | ||||||
AARP2CN (NUC121) domain; This domain is the central domain of AARP2. It is weakly similar to the GTP-binding domain of elongation factor TU. Pssm-ID: 462369 Cd Length: 86 Bit Score: 151.12 E-value: 3.16e-43
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| AARP2CN | smart00785 | AARP2CN (NUC121) domain; This domain is the central domain of AARP2. It is weakly similar to ... |
231-317 | 1.25e-37 | ||||||
AARP2CN (NUC121) domain; This domain is the central domain of AARP2. It is weakly similar to the GTP-binding domain of elongation factor TU. Pssm-ID: 129021 [Multi-domain] Cd Length: 83 Bit Score: 135.38 E-value: 1.25e-37
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| GTP_translation_factor | cd00881 | GTP translation factor family primarily contains translation initiation, elongation and ... |
85-227 | 1.45e-16 | ||||||
GTP translation factor family primarily contains translation initiation, elongation and release factors; The GTP translation factor family consists primarily of translation initiation, elongation, and release factors, which play specific roles in protein translation. In addition, the family includes Snu114p, a component of the U5 small nuclear riboprotein particle which is a component of the spliceosome and is involved in excision of introns, TetM, a tetracycline resistance gene that protects the ribosome from tetracycline binding, and the unusual subfamily CysN/ATPS, which has an unrelated function (ATP sulfurylase) acquired through lateral transfer of the EF1-alpha gene and development of a new function. Pssm-ID: 206647 [Multi-domain] Cd Length: 183 Bit Score: 78.49 E-value: 1.45e-16
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| YeeP | COG3596 | Predicted GTPase [General function prediction only]; |
53-187 | 9.51e-06 | ||||||
Predicted GTPase [General function prediction only]; Pssm-ID: 442815 [Multi-domain] Cd Length: 318 Bit Score: 48.61 E-value: 9.51e-06
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| MMR_HSR1 | pfam01926 | 50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete ... |
85-184 | 1.61e-05 | ||||||
50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete activity of the protein of interacting with the 50S ribosome and binding of both adenine and guanine nucleotides, with a preference for guanine nucleotide. Pssm-ID: 460387 [Multi-domain] Cd Length: 113 Bit Score: 44.92 E-value: 1.61e-05
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| YihA_EngB | cd01876 | YihA (EngB) GTPase family; The YihA (EngB) subfamily of GTPases is typified by the E. coli ... |
85-209 | 3.23e-05 | ||||||
YihA (EngB) GTPase family; The YihA (EngB) subfamily of GTPases is typified by the E. coli YihA, an essential protein involved in cell division control. YihA and its orthologs are small proteins that typically contain less than 200 amino acid residues and consists of the GTPase domain only (some of the eukaryotic homologs contain an N-terminal extension of about 120 residues that might be involved in organellar targeting). Homologs of yihA are found in most Gram-positive and Gram-negative pathogenic bacteria, with the exception of Mycobacterium tuberculosis. The broad-spectrum nature of YihA and its essentiality for cell viability in bacteria make it an attractive antibacterial target. Pssm-ID: 206665 [Multi-domain] Cd Length: 170 Bit Score: 45.19 E-value: 3.23e-05
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| Ras_like_GTPase | cd00882 | Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like ... |
86-187 | 9.49e-05 | ||||||
Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras, Rho, Rab, and Sar1/Arf families. This superfamily also includes proteins like the GTP translation factors, Era-like GTPases, and G-alpha chain of the heterotrimeric G proteins. Members of the Ras superfamily regulate a wide variety of cellular functions: the Ras family regulates gene expression, the Rho family regulates cytoskeletal reorganization and gene expression, the Rab and Sar1/Arf families regulate vesicle trafficking, and the Ran family regulates nucleocytoplasmic transport and microtubule organization. The GTP translation factor family regulates initiation, elongation, termination, and release in translation, and the Era-like GTPase family regulates cell division, sporulation, and DNA replication. Members of the Ras superfamily are identified by the GTP binding site, which is made up of five characteristic sequence motifs, and the switch I and switch II regions. Pssm-ID: 206648 [Multi-domain] Cd Length: 161 Bit Score: 43.60 E-value: 9.49e-05
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| Era | cd04163 | E. coli Ras-like protein (Era) is a multifunctional GTPase; Era (E. coli Ras-like protein) is ... |
85-220 | 1.64e-04 | ||||||
E. coli Ras-like protein (Era) is a multifunctional GTPase; Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria. It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit, possibly by chaperoning the 16S rRNA. It also contacts several assembly elements of the 30S subunit. Era couples cell growth with cytokinesis and plays a role in cell division and energy metabolism. Homologs have also been found in eukaryotes. Era contains two domains: the N-terminal GTPase domain and a C-terminal domain KH domain that is critical for RNA binding. Both domains are important for Era function. Era is functionally able to compensate for deletion of RbfA, a cold-shock adaptation protein that is required for efficient processing of the 16S rRNA. Pssm-ID: 206726 [Multi-domain] Cd Length: 168 Bit Score: 43.22 E-value: 1.64e-04
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| Era_like | cd00880 | E. coli Ras-like protein (Era)-like GTPase; The Era (E. coli Ras-like protein)-like family ... |
86-206 | 7.74e-03 | ||||||
E. coli Ras-like protein (Era)-like GTPase; The Era (E. coli Ras-like protein)-like family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngB), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs), to the exclusion of other GTPases. TrmE is ubiquitous in bacteria and is a widespread mitochondrial protein in eukaryotes, but is absent from archaea. The yeast member of TrmE family, MSS1, is involved in mitochondrial translation; bacterial members are often present in translation-related operons. FeoB represents an unusual adaptation of GTPases for high-affinity iron (II) transport. YihA (EngB) family of GTPases is typified by the E. coli YihA, which is an essential protein involved in cell division control. Era is characterized by a distinct derivative of the KH domain (the pseudo-KH domain) which is located C-terminal to the GTPase domain. EngA and its orthologs are composed of two GTPase domains and, since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an ancient gene duplication, rather than a fusion of evolutionarily distinct GTPases, gave rise to this family. Pssm-ID: 206646 [Multi-domain] Cd Length: 161 Bit Score: 38.00 E-value: 7.74e-03
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| YlqF | cd01856 | Circularly permuted YlqF GTPase; Proteins of the YlqF family contain all sequence motifs ... |
51-104 | 7.81e-03 | ||||||
Circularly permuted YlqF GTPase; Proteins of the YlqF family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases. The YlqF subfamily is represented in all eukaryotes as well as a phylogenetically diverse array of bacteria (including gram-positive bacteria, proteobacteria, Synechocystis, Borrelia, and Thermotoga). Pssm-ID: 206749 [Multi-domain] Cd Length: 171 Bit Score: 38.28 E-value: 7.81e-03
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| GTP_EFTU | pfam00009 | Elongation factor Tu GTP binding domain; This domain contains a P-loop motif, also found in ... |
85-210 | 9.76e-03 | ||||||
Elongation factor Tu GTP binding domain; This domain contains a P-loop motif, also found in several other families such as pfam00071, pfam00025 and pfam00063. Elongation factor Tu consists of three structural domains, this plus two C-terminal beta barrel domains. Pssm-ID: 425418 [Multi-domain] Cd Length: 187 Bit Score: 38.27 E-value: 9.76e-03
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