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Conserved domains on  [gi|2217284823|ref|XP_047283595|]
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proteasomal ATPase-associated factor 1 isoform X1 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 89-338 3.31e-36

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 132.46  E-value: 3.31e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284823  89 RIHTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASC 168
Cdd:cd00200     6 KGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGEC 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284823 169 VVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSACLGVLADCGSSINGVAV---------GAADNSINLGSPE 239
Cdd:cd00200    86 VRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFspdgtfvasSSQDGTIKLWDLR 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284823 240 qmpSEREVGT---------------EAKMLLLAREDKKLQCLGLQSRQLVFLFIG-SDAFNCCTFL-SGFLLLAGTQDGN 302
Cdd:cd00200   166 ---TGKCVATltghtgevnsvafspDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGhENGVNSVAFSpDGYLLASGSEDGT 242

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 2217284823 303 IYQLDVRSPRaPVQVIHRSGAPVLSLLSVRDG-FIAS 338
Cdd:cd00200   243 IRVWDLRTGE-CVQTLSGHTNSVTSLAWSPDGkRLAS 278
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 89-338 3.31e-36

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 132.46  E-value: 3.31e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284823  89 RIHTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASC 168
Cdd:cd00200     6 KGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGEC 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284823 169 VVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSACLGVLADCGSSINGVAV---------GAADNSINLGSPE 239
Cdd:cd00200    86 VRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFspdgtfvasSSQDGTIKLWDLR 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284823 240 qmpSEREVGT---------------EAKMLLLAREDKKLQCLGLQSRQLVFLFIG-SDAFNCCTFL-SGFLLLAGTQDGN 302
Cdd:cd00200   166 ---TGKCVATltghtgevnsvafspDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGhENGVNSVAFSpDGYLLASGSEDGT 242

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 2217284823 303 IYQLDVRSPRaPVQVIHRSGAPVLSLLSVRDG-FIAS 338
Cdd:cd00200   243 IRVWDLRTGE-CVQTLSGHTNSVTSLAWSPDGkRLAS 278
WD40 COG2319
WD40 repeat [General function prediction only];
91-338 1.30e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 128.11  E-value: 1.30e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284823  91 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVV 170
Cdd:COG2319   119 HTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR 198

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284823 171 TFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSACLGVLADCGSSINGVAVgaadnsinlgSPeqmpserevgtE 250
Cdd:COG2319   199 TLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAF----------SP-----------D 257

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284823 251 AKMLLLAREDKKLQCLGLQSRQLVFLFIG-SDAFNCCTFL-SGFLLLAGTQDGNIYQLDVRSPRaPVQVIHRSGAPVLSL 328
Cdd:COG2319   258 GRLLASGSADGTVRLWDLATGELLRTLTGhSGGVNSVAFSpDGKLLASGSDDGTVRLWDLATGK-LLRTLTGHTGAVRSV 336

                         250
                  ....*....|.
gi 2217284823 329 LSVRDG-FIAS 338
Cdd:COG2319   337 AFSPDGkTLAS 347
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 123-162 8.35e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 8.35e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2217284823  123 NGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWS 162
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
167-204 2.81e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.49  E-value: 2.81e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2217284823 167 SCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWD 204
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 91-209 2.06e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 43.15  E-value: 2.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284823  91 HTKSITCLDISSRG-GLGVSSSTDGTMKIWQASNGelrrVLEGHV-FDVN-CCRFFPS--GLVVLSGGMDAQLKIWSAED 165
Cdd:PLN00181  574 HEKRVWSIDYSSADpTLLASGSDDGSVKLWSINQG----VSIGTIkTKANiCCVQFPSesGRSLAFGSADHKVYYYDLRN 649

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2217284823 166 ASC-VVTFKGHKGGILDTAIVDRGrNVVSASRDGTARLWDCGRSA 209
Cdd:PLN00181  650 PKLpLCTMIGHSKTVSYVRFVDSS-TLVSSSTDNTLKLWDLSMSI 693
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 89-338 3.31e-36

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 132.46  E-value: 3.31e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284823  89 RIHTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASC 168
Cdd:cd00200     6 KGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGEC 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284823 169 VVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSACLGVLADCGSSINGVAV---------GAADNSINLGSPE 239
Cdd:cd00200    86 VRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFspdgtfvasSSQDGTIKLWDLR 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284823 240 qmpSEREVGT---------------EAKMLLLAREDKKLQCLGLQSRQLVFLFIG-SDAFNCCTFL-SGFLLLAGTQDGN 302
Cdd:cd00200   166 ---TGKCVATltghtgevnsvafspDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGhENGVNSVAFSpDGYLLASGSEDGT 242

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 2217284823 303 IYQLDVRSPRaPVQVIHRSGAPVLSLLSVRDG-FIAS 338
Cdd:cd00200   243 IRVWDLRTGE-CVQTLSGHTNSVTSLAWSPDGkRLAS 278
WD40 COG2319
WD40 repeat [General function prediction only];
91-338 1.30e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 128.11  E-value: 1.30e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284823  91 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVV 170
Cdd:COG2319   119 HTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR 198

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284823 171 TFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSACLGVLADCGSSINGVAVgaadnsinlgSPeqmpserevgtE 250
Cdd:COG2319   199 TLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAF----------SP-----------D 257

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284823 251 AKMLLLAREDKKLQCLGLQSRQLVFLFIG-SDAFNCCTFL-SGFLLLAGTQDGNIYQLDVRSPRaPVQVIHRSGAPVLSL 328
Cdd:COG2319   258 GRLLASGSADGTVRLWDLATGELLRTLTGhSGGVNSVAFSpDGKLLASGSDDGTVRLWDLATGK-LLRTLTGHTGAVRSV 336

                         250
                  ....*....|.
gi 2217284823 329 LSVRDG-FIAS 338
Cdd:COG2319   337 AFSPDGkTLAS 347
WD40 COG2319
WD40 repeat [General function prediction only];
91-235 8.29e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 115.01  E-value: 8.29e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284823  91 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVV 170
Cdd:COG2319   245 HSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR 324

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217284823 171 TFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSACLGVLADCGSSINGV---------AVGAADNSINL 235
Cdd:COG2319   325 TLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVafspdgrtlASGSADGTVRL 398
WD40 COG2319
WD40 repeat [General function prediction only];
91-204 6.65e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 106.92  E-value: 6.65e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284823  91 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVV 170
Cdd:COG2319   287 HSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLR 366

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2217284823 171 TFKGHKGGILDTAIVDRGRNVVSASRDGTARLWD 204
Cdd:COG2319   367 TLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 91-204 2.31e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 97.79  E-value: 2.31e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284823  91 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVV 170
Cdd:cd00200   176 HTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQ 255

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2217284823 171 TFKGHKGGILDTAIVDRGRNVVSASRDGTARLWD 204
Cdd:cd00200   256 TLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 126-319 3.52e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 92.01  E-value: 3.52e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284823 126 LRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDC 205
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284823 206 GRSACLGVLADCGSSINGVAVgaadnsinlgspeqMPSERevgteakMLLLAREDKKLQCLGLQSRQLVFLFIG-SDAFN 284
Cdd:cd00200    81 ETGECVRTLTGHTSYVSSVAF--------------SPDGR-------ILSSSSRDKTIKVWDVETGKCLTTLRGhTDWVN 139

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 2217284823 285 CCTFL-SGFLLLAGTQDGNIYQLDVRSPRaPVQVIH 319
Cdd:cd00200   140 SVAFSpDGTFVASSSQDGTIKLWDLRTGK-CVATLT 174
WD40 COG2319
WD40 repeat [General function prediction only];
89-338 1.54e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 91.90  E-value: 1.54e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284823  89 RIHTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASC 168
Cdd:COG2319    33 LGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLL 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284823 169 VVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSACLGVLADCGSSINGVA---------VGAADNSI---NLG 236
Cdd:COG2319   113 LRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAfspdgkllaSGSDDGTVrlwDLA 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284823 237 SPEQMPS----EREVGTEA-----KMLLLAREDKKLQCLGLQSRQLVFLFIG-SDAFNCCTFLS-GFLLLAGTQDGNIYQ 305
Cdd:COG2319   193 TGKLLRTltghTGAVRSVAfspdgKLLASGSADGTVRLWDLATGKLLRTLTGhSGSVRSVAFSPdGRLLASGSADGTVRL 272

                         250       260       270
                  ....*....|....*....|....*....|....
gi 2217284823 306 LDVRSPRaPVQVIHRSGAPVLSLLSVRDG-FIAS 338
Cdd:COG2319   273 WDLATGE-LLRTLTGHSGGVNSVAFSPDGkLLAS 305
WD40 COG2319
WD40 repeat [General function prediction only];
101-338 3.05e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 69.94  E-value: 3.05e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284823 101 SSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGIL 180
Cdd:COG2319     3 SADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284823 181 DTAIVDRGRNVVSASRDGTARLWDCGRSACLGVLADCGSSINGVAV---------GAADNSI---NLGSPEQMPSEREVG 248
Cdd:COG2319    83 SVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFspdgktlasGSADGTVrlwDLATGKLLRTLTGHS 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284823 249 TEA---------KMLLLAREDKKLQCLGLQSRQLVFLFIG-SDAFNCCTFLS-GFLLLAGTQDGNIYQLDVRSPRaPVQV 317
Cdd:COG2319   163 GAVtsvafspdgKLLASGSDDGTVRLWDLATGKLLRTLTGhTGAVRSVAFSPdGKLLASGSADGTVRLWDLATGK-LLRT 241

                         250       260
                  ....*....|....*....|..
gi 2217284823 318 IHRSGAPVLSLLSVRDG-FIAS 338
Cdd:COG2319   242 LTGHSGSVRSVAFSPDGrLLAS 263
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 89-162 4.41e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 68.52  E-value: 4.41e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217284823  89 RIHTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWS 162
Cdd:cd00200   216 RGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
91-165 3.72e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 66.86  E-value: 3.72e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2217284823  91 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAED 165
Cdd:COG2319   329 HTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 123-162 8.35e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 8.35e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2217284823  123 NGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWS 162
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 167-204 9.87e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 9.87e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2217284823  167 SCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWD 204
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
167-204 2.81e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.49  E-value: 2.81e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2217284823 167 SCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWD 204
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
124-162 6.79e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 6.79e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2217284823 124 GELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWS 162
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 91-209 2.06e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 43.15  E-value: 2.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217284823  91 HTKSITCLDISSRG-GLGVSSSTDGTMKIWQASNGelrrVLEGHV-FDVN-CCRFFPS--GLVVLSGGMDAQLKIWSAED 165
Cdd:PLN00181  574 HEKRVWSIDYSSADpTLLASGSDDGSVKLWSINQG----VSIGTIkTKANiCCVQFPSesGRSLAFGSADHKVYYYDLRN 649

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2217284823 166 ASC-VVTFKGHKGGILDTAIVDRGrNVVSASRDGTARLWDCGRSA 209
Cdd:PLN00181  650 PKLpLCTMIGHSKTVSYVRFVDSS-TLVSSSTDNTLKLWDLSMSI 693
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 91-119 2.80e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 2.80e-04
                           10        20
                   ....*....|....*....|....*....
gi 2217284823   91 HTKSITCLDISSRGGLGVSSSTDGTMKIW 119
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
91-119 3.17e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 3.17e-04
                          10        20
                  ....*....|....*....|....*....
gi 2217284823  91 HTKSITCLDISSRGGLGVSSSTDGTMKIW 119
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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