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Conserved domains on  [gi|2217270975|ref|XP_047286779|]
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zinc finger protein 672 isoform X1 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
12-413 2.11e-13

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.04  E-value: 2.11e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217270975  12 KPYSCSECGKSFCYSSVLLRHERAHGGDGRFRCLECGERCA--RAADLRAHRRTHAGQTLYICSECGQSFRHSGRLDLHL 89
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSfsRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217270975  90 GAHRQRCRTCPCRTCG------RRFPHLPALLLHRRRQHLPerprRCPLCARTFRQSALLFHQARAHPLGT--------- 154
Cdd:COG5048   112 SSSSNSNDNNLLSSHSlppssrDPQLPDLLSISNLRNNPLP----GNNSSSVNTPQSNSLHPPLPANSLSKdpssnlsll 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217270975 155 TSDPAAPPHRCAQCPRAFRSGAGLRSHARIHVSRSPTRPrvSDAHQCGVCGKcfgKSSTLTRHLQTHSGEKPFKCPECGK 234
Cdd:COG5048   188 ISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSS--LPLTTNSQLSP---KSLLSQSPSSLSSSDSSSSASESPR 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217270975 235 GFLESATLVRHQRTHTGE-------KPYACGDCGRCFSESSTLLRHRRS--HQGE--RPHAC--ATCGKGFGQRSDLVVH 301
Cdd:COG5048   263 SSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRH 342

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217270975 302 QRIHTGEKPFACPECGRRFSDRSDLTK-------HRRTHTGEKPYRCELCGKRFTCVSNLNV--HRRNHAGHKPH--KCP 370
Cdd:COG5048   343 ILLHTSISPAKEKLLNSSSKFSPLLNNeppqslqQYKDLKNDKKSETLSNSCIRNFKRDSNLslHIITHLSFRPYncKNP 422

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|...
gi 2217270975 371 ECSKAFSVASKLALHRKTHLGERPAECaeCGKCFSHSRSLSQH 413
Cdd:COG5048   423 PCSKSFNRHYNLIPHKKIHTNHAPLLC--SILKSFRRDLDLSN 463
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
12-413 2.11e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.04  E-value: 2.11e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217270975  12 KPYSCSECGKSFCYSSVLLRHERAHGGDGRFRCLECGERCA--RAADLRAHRRTHAGQTLYICSECGQSFRHSGRLDLHL 89
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSfsRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217270975  90 GAHRQRCRTCPCRTCG------RRFPHLPALLLHRRRQHLPerprRCPLCARTFRQSALLFHQARAHPLGT--------- 154
Cdd:COG5048   112 SSSSNSNDNNLLSSHSlppssrDPQLPDLLSISNLRNNPLP----GNNSSSVNTPQSNSLHPPLPANSLSKdpssnlsll 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217270975 155 TSDPAAPPHRCAQCPRAFRSGAGLRSHARIHVSRSPTRPrvSDAHQCGVCGKcfgKSSTLTRHLQTHSGEKPFKCPECGK 234
Cdd:COG5048   188 ISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSS--LPLTTNSQLSP---KSLLSQSPSSLSSSDSSSSASESPR 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217270975 235 GFLESATLVRHQRTHTGE-------KPYACGDCGRCFSESSTLLRHRRS--HQGE--RPHAC--ATCGKGFGQRSDLVVH 301
Cdd:COG5048   263 SSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRH 342

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217270975 302 QRIHTGEKPFACPECGRRFSDRSDLTK-------HRRTHTGEKPYRCELCGKRFTCVSNLNV--HRRNHAGHKPH--KCP 370
Cdd:COG5048   343 ILLHTSISPAKEKLLNSSSKFSPLLNNeppqslqQYKDLKNDKKSETLSNSCIRNFKRDSNLslHIITHLSFRPYncKNP 422

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|...
gi 2217270975 371 ECSKAFSVASKLALHRKTHLGERPAECaeCGKCFSHSRSLSQH 413
Cdd:COG5048   423 PCSKSFNRHYNLIPHKKIHTNHAPLLC--SILKSFRRDLDLSN 463
zf-H2C2_2 pfam13465
Zinc-finger double domain;
325-350 7.00e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.00e-04
                          10        20
                  ....*....|....*....|....*.
gi 2217270975 325 DLTKHRRTHTGEKPYRCELCGKRFTC 350
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 309-357 2.04e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 37.15  E-value: 2.04e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2217270975 309 KPFaCPECGRRFSDRSDLTKHRRTHTgekpYRCELCGKRFTCVSNLNVH 357
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVH 44
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
12-413 2.11e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.04  E-value: 2.11e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217270975  12 KPYSCSECGKSFCYSSVLLRHERAHGGDGRFRCLECGERCA--RAADLRAHRRTHAGQTLYICSECGQSFRHSGRLDLHL 89
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSfsRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217270975  90 GAHRQRCRTCPCRTCG------RRFPHLPALLLHRRRQHLPerprRCPLCARTFRQSALLFHQARAHPLGT--------- 154
Cdd:COG5048   112 SSSSNSNDNNLLSSHSlppssrDPQLPDLLSISNLRNNPLP----GNNSSSVNTPQSNSLHPPLPANSLSKdpssnlsll 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217270975 155 TSDPAAPPHRCAQCPRAFRSGAGLRSHARIHVSRSPTRPrvSDAHQCGVCGKcfgKSSTLTRHLQTHSGEKPFKCPECGK 234
Cdd:COG5048   188 ISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSS--LPLTTNSQLSP---KSLLSQSPSSLSSSDSSSSASESPR 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217270975 235 GFLESATLVRHQRTHTGE-------KPYACGDCGRCFSESSTLLRHRRS--HQGE--RPHAC--ATCGKGFGQRSDLVVH 301
Cdd:COG5048   263 SSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRH 342

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217270975 302 QRIHTGEKPFACPECGRRFSDRSDLTK-------HRRTHTGEKPYRCELCGKRFTCVSNLNV--HRRNHAGHKPH--KCP 370
Cdd:COG5048   343 ILLHTSISPAKEKLLNSSSKFSPLLNNeppqslqQYKDLKNDKKSETLSNSCIRNFKRDSNLslHIITHLSFRPYncKNP 422

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|...
gi 2217270975 371 ECSKAFSVASKLALHRKTHLGERPAECaeCGKCFSHSRSLSQH 413
Cdd:COG5048   423 PCSKSFNRHYNLIPHKKIHTNHAPLLC--SILKSFRRDLDLSN 463
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
162-329 4.86e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.92  E-value: 4.86e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217270975 162 PHRCAQCPRAFRSGAGLRSHAR-IHVSRSPTRPrvsdaHQCGV--CGKCFGKSSTLTRHLQTHSGEKPFKCP--ECGKGF 236
Cdd:COG5048   289 PIKSKQCNISFSRSSPLTRHLRsVNHSGESLKP-----FSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKF 363

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217270975 237 LESATLVRHQRTH-----TGEKPYAC--GDCGRCFSESSTLLRHRRSHQGERPHAC--ATCGKGFGQRSDLVVHQRIHTg 307
Cdd:COG5048   364 SPLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHT- 442

                         170       180
                  ....*....|....*....|..
gi 2217270975 308 EKPFACPECGRRFSDRSDLTKH 329
Cdd:COG5048   443 NHAPLLCSILKSFRRDLDLSNH 464
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 307-364 8.44e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.71  E-value: 8.44e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2217270975 307 GEKPFACP--ECGRRFSDRSDLTKHR-------RTH------------TGEKPYRCELCGKRFTCVSNLNVHRRnHAGH 364
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHMlhghqnqKLHenpspekmnifsAKDKPYRCEVCDKRYKNLNGLKYHRK-HSHD 423
zf-H2C2_2 pfam13465
Zinc-finger double domain;
325-350 7.00e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.00e-04
                          10        20
                  ....*....|....*....|....*.
gi 2217270975 325 DLTKHRRTHTGEKPYRCELCGKRFTC 350
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
214-236 1.78e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.78e-03
                          10        20
                  ....*....|....*....|...
gi 2217270975 214 LTRHLQTHSGEKPFKCPECGKGF 236
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 309-357 2.04e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 37.15  E-value: 2.04e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2217270975 309 KPFaCPECGRRFSDRSDLTKHRRTHTgekpYRCELCGKRFTCVSNLNVH 357
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVH 44
zf-H2C2_2 pfam13465
Zinc-finger double domain;
297-321 2.27e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.27e-03
                          10        20
                  ....*....|....*....|....*
gi 2217270975 297 DLVVHQRIHTGEKPFACPECGRRFS 321
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
353-377 5.14e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 5.14e-03
                          10        20
                  ....*....|....*....|....*
gi 2217270975 353 NLNVHRRNHAGHKPHKCPECSKAFS 377
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 311-333 6.23e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 6.23e-03
                          10        20
                  ....*....|....*....|...
gi 2217270975 311 FACPECGRRFSDRSDLTKHRRTH 333
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
242-265 9.36e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.50  E-value: 9.36e-03
                          10        20
                  ....*....|....*....|....
gi 2217270975 242 LVRHQRTHTGEKPYACGDCGRCFS 265
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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