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Conserved domains on  [gi|2217301169|ref|XP_047288490|]
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lactadherin isoform X2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 64-216 1.11e-48

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


:

Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 159.83  E-value: 1.11e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301169  64 EPLGLENGnIANSQIAASSVRVTFlglqhWVPELARLNRagmVNAWTPSSNDDNPWIQVNLLRRMWVTGVVTQGASRLAS 143
Cdd:cd00057     1 EPLGMESG-LADDQITASSSYSSG-----WEASRARLNS---DNAWTPAVNDPPQWLQVDLGKTRRVTGIQTQGRKGGGS 71

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217301169 144 HEYLKAFKVAYSLNGHEFDFIHDvNKKHKEFVGNWNKNAVHVNLFETPVEAQYVRLYPTSCHTACTLRFELLG 216
Cdd:cd00057    72 SEWVTSYKVQYSLDGETWTTYKD-KGEEKVFTGNSDGSTPVTNDFPPPIVARYIRILPTTWNGNISLRLELYG 143
FA58C smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 221-327 1.85e-18

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


:

Pssm-ID: 214572  Cd Length: 139  Bit Score: 80.25  E-value: 1.85e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301169  221 GCANPLGLKNNSipdkQITASSSYktwglhlfsWNPSYARLDKQGNfNAWVAGSYGNDQWLQI----------------- 283
Cdd:smart00231   1 PCNEPLGLESDS----QITASSSY---------WAAKIARLNGGSD-GGWCPAKNDLPPWIQVdlgrlrtvtgvitgrrh 66

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217301169  284 -----------------------------FPGNWDNHSHKKNLFETPILARYVRILPVAWHNRIALRLELLGC 327
Cdd:smart00231  67 gngdwvtykleysddgvnwttykdgnskvFPGNSDAGTVVLNDFPPPIVARYVRILPTGWNGNIILRVELLGC 139
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 20-59 5.40e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 5.40e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2217301169  20 SKNPCHNGGLCEeisqevrgDVFPSYTCTCLKGYAGNHCE 59
Cdd:cd00054     7 SGNPCQNGGTCV--------NTVGSYRCSCPPGYTGRNCE 38
 
Name Accession Description Interval E-value
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 64-216 1.11e-48

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 159.83  E-value: 1.11e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301169  64 EPLGLENGnIANSQIAASSVRVTFlglqhWVPELARLNRagmVNAWTPSSNDDNPWIQVNLLRRMWVTGVVTQGASRLAS 143
Cdd:cd00057     1 EPLGMESG-LADDQITASSSYSSG-----WEASRARLNS---DNAWTPAVNDPPQWLQVDLGKTRRVTGIQTQGRKGGGS 71

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217301169 144 HEYLKAFKVAYSLNGHEFDFIHDvNKKHKEFVGNWNKNAVHVNLFETPVEAQYVRLYPTSCHTACTLRFELLG 216
Cdd:cd00057    72 SEWVTSYKVQYSLDGETWTTYKD-KGEEKVFTGNSDGSTPVTNDFPPPIVARYIRILPTTWNGNISLRLELYG 143
FA58C smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 61-217 9.88e-35

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 214572  Cd Length: 139  Bit Score: 123.39  E-value: 9.88e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301169   61 KCVEPLGLENgniaNSQIAASSvrvtflglQHWVPELARLNRaGMVNAWTPSSNDDNPWIQVNLLRRMWVTGVVTQgasR 140
Cdd:smart00231   1 PCNEPLGLES----DSQITASS--------SYWAAKIARLNG-GSDGGWCPAKNDLPPWIQVDLGRLRTVTGVITG---R 64

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217301169  141 LASHEYLKAFKVAYSLNGHEFDFIHDVNkkHKEFVGNWNKNAVHVNLFETPVEAQYVRLYPTSCHTACTLRFELLGC 217
Cdd:smart00231  65 RHGNGDWVTYKLEYSDDGVNWTTYKDGN--SKVFPGNSDAGTVVLNDFPPPIVARYVRILPTGWNGNIILRVELLGC 139
F5_F8_type_C pfam00754
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.
 77-214 3.41e-27

F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.


Pssm-ID: 459925 [Multi-domain]  Cd Length: 127  Bit Score: 103.30  E-value: 3.41e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301169  77 QIAASSVRvtflgLQHWVPElARLNraGMVN-AWTPSSNDDNPWIQVNLLRRMWVTGVVTQGASRlASHEYLKAFKVAYS 155
Cdd:pfam00754   1 QITASSSY-----SGEGPAA-AALD--GDPNtAWSAWSGDDPQWIQVDLGKPKKITGVVTQGRQD-GSNGYVTSYKIEYS 71

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217301169 156 LNGHEFDFIHDVnkkhkEFVGNWNKNAVHVNLFETPVEAQYVRLYPTSCHT--ACTLRFEL 214
Cdd:pfam00754  72 LDGENWTTVKDE-----KIPGNNDNNTPVTNTFDPPIKARYVRIVPTSWNGgnGIALRAEL 127
FA58C smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 221-327 1.85e-18

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 214572  Cd Length: 139  Bit Score: 80.25  E-value: 1.85e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301169  221 GCANPLGLKNNSipdkQITASSSYktwglhlfsWNPSYARLDKQGNfNAWVAGSYGNDQWLQI----------------- 283
Cdd:smart00231   1 PCNEPLGLESDS----QITASSSY---------WAAKIARLNGGSD-GGWCPAKNDLPPWIQVdlgrlrtvtgvitgrrh 66

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217301169  284 -----------------------------FPGNWDNHSHKKNLFETPILARYVRILPVAWHNRIALRLELLGC 327
Cdd:smart00231  67 gngdwvtykleysddgvnwttykdgnskvFPGNSDAGTVVLNDFPPPIVARYVRILPTGWNGNIILRVELLGC 139
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 20-59 5.40e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 5.40e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2217301169  20 SKNPCHNGGLCEeisqevrgDVFPSYTCTCLKGYAGNHCE 59
Cdd:cd00054     7 SGNPCQNGGTCV--------NTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 19-57 8.24e-06

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.98  E-value: 8.24e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2217301169  19 CSKNPCHNGGLCEeisqevrgDVFPSYTCTCLKGYAGNH 57
Cdd:pfam00008   1 CAPNPCSNGGTCV--------DTPGGYTCICPEGYTGKR 31
 
Name Accession Description Interval E-value
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 64-216 1.11e-48

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 159.83  E-value: 1.11e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301169  64 EPLGLENGnIANSQIAASSVRVTFlglqhWVPELARLNRagmVNAWTPSSNDDNPWIQVNLLRRMWVTGVVTQGASRLAS 143
Cdd:cd00057     1 EPLGMESG-LADDQITASSSYSSG-----WEASRARLNS---DNAWTPAVNDPPQWLQVDLGKTRRVTGIQTQGRKGGGS 71

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217301169 144 HEYLKAFKVAYSLNGHEFDFIHDvNKKHKEFVGNWNKNAVHVNLFETPVEAQYVRLYPTSCHTACTLRFELLG 216
Cdd:cd00057    72 SEWVTSYKVQYSLDGETWTTYKD-KGEEKVFTGNSDGSTPVTNDFPPPIVARYIRILPTTWNGNISLRLELYG 143
FA58C smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 61-217 9.88e-35

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 214572  Cd Length: 139  Bit Score: 123.39  E-value: 9.88e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301169   61 KCVEPLGLENgniaNSQIAASSvrvtflglQHWVPELARLNRaGMVNAWTPSSNDDNPWIQVNLLRRMWVTGVVTQgasR 140
Cdd:smart00231   1 PCNEPLGLES----DSQITASS--------SYWAAKIARLNG-GSDGGWCPAKNDLPPWIQVDLGRLRTVTGVITG---R 64

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217301169  141 LASHEYLKAFKVAYSLNGHEFDFIHDVNkkHKEFVGNWNKNAVHVNLFETPVEAQYVRLYPTSCHTACTLRFELLGC 217
Cdd:smart00231  65 RHGNGDWVTYKLEYSDDGVNWTTYKDGN--SKVFPGNSDAGTVVLNDFPPPIVARYVRILPTGWNGNIILRVELLGC 139
F5_F8_type_C pfam00754
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.
 77-214 3.41e-27

F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.


Pssm-ID: 459925 [Multi-domain]  Cd Length: 127  Bit Score: 103.30  E-value: 3.41e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301169  77 QIAASSVRvtflgLQHWVPElARLNraGMVN-AWTPSSNDDNPWIQVNLLRRMWVTGVVTQGASRlASHEYLKAFKVAYS 155
Cdd:pfam00754   1 QITASSSY-----SGEGPAA-AALD--GDPNtAWSAWSGDDPQWIQVDLGKPKKITGVVTQGRQD-GSNGYVTSYKIEYS 71

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217301169 156 LNGHEFDFIHDVnkkhkEFVGNWNKNAVHVNLFETPVEAQYVRLYPTSCHT--ACTLRFEL 214
Cdd:pfam00754  72 LDGENWTTVKDE-----KIPGNNDNNTPVTNTFDPPIKARYVRIVPTSWNGgnGIALRAEL 127
FA58C smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 221-327 1.85e-18

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 214572  Cd Length: 139  Bit Score: 80.25  E-value: 1.85e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301169  221 GCANPLGLKNNSipdkQITASSSYktwglhlfsWNPSYARLDKQGNfNAWVAGSYGNDQWLQI----------------- 283
Cdd:smart00231   1 PCNEPLGLESDS----QITASSSY---------WAAKIARLNGGSD-GGWCPAKNDLPPWIQVdlgrlrtvtgvitgrrh 66

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217301169  284 -----------------------------FPGNWDNHSHKKNLFETPILARYVRILPVAWHNRIALRLELLGC 327
Cdd:smart00231  67 gngdwvtykleysddgvnwttykdgnskvFPGNSDAGTVVLNDFPPPIVARYVRILPTGWNGNIILRVELLGC 139
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 20-59 5.40e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 5.40e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2217301169  20 SKNPCHNGGLCEeisqevrgDVFPSYTCTCLKGYAGNHCE 59
Cdd:cd00054     7 SGNPCQNGGTCV--------NTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 19-57 8.24e-06

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.98  E-value: 8.24e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2217301169  19 CSKNPCHNGGLCEeisqevrgDVFPSYTCTCLKGYAGNH 57
Cdd:pfam00008   1 CAPNPCSNGGTCV--------DTPGGYTCICPEGYTGKR 31
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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