lactadherin isoform X4 [Homo sapiens]
calcium-binding EGF-like domain-containing protein; discoidin domain-containing receptor( domain architecture ID 10041971)
calcium-binding epidermal growth factor (EGF)-like domain-containing protein may play a crucial role in numerous protein-protein interactions; discoidin domain-containing receptor (DDR) is a tyrosine-protein kinase that catalyzes the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates
List of domain hits
Name | Accession | Description | Interval | E-value | |||
FA58C | cd00057 | Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ... |
64-216 | 3.23e-51 | |||
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes. : Pssm-ID: 238014 [Multi-domain] Cd Length: 143 Bit Score: 163.29 E-value: 3.23e-51
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EGF_CA | cd00054 | Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
20-59 | 9.86e-06 | |||
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements. : Pssm-ID: 238011 Cd Length: 38 Bit Score: 41.47 E-value: 9.86e-06
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Name | Accession | Description | Interval | E-value | |||
FA58C | cd00057 | Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ... |
64-216 | 3.23e-51 | |||
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes. Pssm-ID: 238014 [Multi-domain] Cd Length: 143 Bit Score: 163.29 E-value: 3.23e-51
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FA58C | smart00231 | Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ... |
61-217 | 5.60e-37 | |||
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes. Pssm-ID: 214572 Cd Length: 139 Bit Score: 126.47 E-value: 5.60e-37
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F5_F8_type_C | pfam00754 | F5/8 type C domain; This domain is also known as the discoidin (DS) domain family. |
77-214 | 1.64e-29 | |||
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family. Pssm-ID: 459925 [Multi-domain] Cd Length: 127 Bit Score: 107.15 E-value: 1.64e-29
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EGF_CA | cd00054 | Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
20-59 | 9.86e-06 | |||
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements. Pssm-ID: 238011 Cd Length: 38 Bit Score: 41.47 E-value: 9.86e-06
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EGF | pfam00008 | EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ... |
19-57 | 1.44e-05 | |||
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains. Pssm-ID: 394967 Cd Length: 31 Bit Score: 40.83 E-value: 1.44e-05
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Name | Accession | Description | Interval | E-value | |||
FA58C | cd00057 | Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ... |
64-216 | 3.23e-51 | |||
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes. Pssm-ID: 238014 [Multi-domain] Cd Length: 143 Bit Score: 163.29 E-value: 3.23e-51
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FA58C | smart00231 | Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ... |
61-217 | 5.60e-37 | |||
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes. Pssm-ID: 214572 Cd Length: 139 Bit Score: 126.47 E-value: 5.60e-37
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F5_F8_type_C | pfam00754 | F5/8 type C domain; This domain is also known as the discoidin (DS) domain family. |
77-214 | 1.64e-29 | |||
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family. Pssm-ID: 459925 [Multi-domain] Cd Length: 127 Bit Score: 107.15 E-value: 1.64e-29
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EGF_CA | cd00054 | Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
20-59 | 9.86e-06 | |||
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements. Pssm-ID: 238011 Cd Length: 38 Bit Score: 41.47 E-value: 9.86e-06
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EGF | pfam00008 | EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ... |
19-57 | 1.44e-05 | |||
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains. Pssm-ID: 394967 Cd Length: 31 Bit Score: 40.83 E-value: 1.44e-05
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Blast search parameters | ||||
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